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The initiation of osteodentin formation in the rat incisor after adriamycin administration

In order to study the initiation of osteodentin formation in rat incisors, animals were injected intravenously with adriamycin (5 mg/kg body weight), and killed from 2 to 7 days after injection by perfusion with a 2.5% buffered glutaraldehyde solution. Control animals, injected with only physiological saline, were treated in the same manner.