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Label-free, Phenotypic Analysis of the Endogenous GABAa Receptor in iPSC-Derived Neurons

There is a growing need for more relevant and predictive functional cell-based assays during the drug discovery process. Assays that require a label for detection can potentially limit the view of drug effects due to false positives, false negatives, or limited breadth of data. In addition, when using labeled technologies, engineered cell lines are often required, further deviating from a true predictive model of cell biology. Label-free technology has been demonstrated to be a robust, highly sensitive, tool used to measure live, native cells (including stem and primary cells) in real time without the need for dyes, tags, engineered cells, or other special reagents. Most importantly, label-free technology allows for measurement of the integrative phenotypic response that results from multiple signaling interactions, enabling scientists to observe the entire cellular model instead of one single biomarker of interest. Increasing evidence suggests that the use of label-free screening assays yields a higher rate of success in prioritizing and advancing lead compounds in drug discovery research environments. Label-free, Phenotypic Analysis of the Endogenous GABAA Receptor in iPSC-Derived Neurons A P P L I C A T I O N N O T E