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Regulation of ribosomal function by oligomeric tau

Accumulation of tau pathology is a core feature of Alzheimer’s disease (AD) and related tauopathies, but tau pathology is pleiotropic. The many species of tau oligomers/aggregates has prevented elucidation of the mechanisms by which tau induces neurodegeneration. Fibrillary tau aggregates are considered to be less toxic than tau oligomers, but have received extensive attention because they are readily identifiable with pathological dyes, such as thioflavines, as well as by reagents used for diagnostic imaging. Multiple studies indicate that oligomeric tau (oTau) is the key toxic species, but the mechanism of toxicity is unknown