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Distinguishing nonalcoholic steatohepatitis from fatty liver: serum‐free fatty acids, insulin resistance, and serum lipoproteins

Abstract: Objectives: The prognosis of nonalcoholic fatty liver disease is determined by liver biopsy; steatohepatitis can be progressive whereas fatty liver is benign. Insulin resistance and increased hepatic‐free fatty acids are central to the pathophysiology of this disorder. Our objective was to assess whether serum‐free fatty acids, lipoproteins, and insulin resistance are increased in steatohepatitis compared with fatty liver and healthy controls, and thus may be potential noninvasive markers for liver disease severity.