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A comparative study evaluating the utility of EGF, FGF-2, and ofloxacin drops on eardrum regeneration

Results: At one week post insertion of antibiotic laden pellets marked ABR threshold elevation (15–40 dB) was observed (P< 0.002–0.0001) against control groups. Persistent significant elevation (25–40 dB) was apparent at 8 and 30 kHz at week 16 with some partial mid frequency recovery. No significant changes in ABR wave amplitudes and latencies were seen. Representative cytocochleograms did not exhibit frank hair cell loss and middle ear histology revealed pellet remnants causing a moderate inflammatory response at 16 weeks.