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Analysis of cytogenetic alterations in asthmatic patients treated with beclometasone dipropionate

Inhaled corticosteroids (ICSs) are indicated in the management of most asthmatic patients, and the assessment of possible cytogenetic effects of these medicines seem to be important. The frequencies of chromosomal aberrations (CA) and sister-chromatid exchanges (SCE) in peripheral blood lymphocytes, as well as micronuclei (MN) frequencies in buccal epithelial cells were scored for 26 asthmatics treated with beclometasone dipropionate-HFA at 400 mcg/day. The control group consisted of 20 healthy subjects. The significant (p 0.05). However, patients treated with ICSs had significantly (p