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Progress towards brain organoid models with representative neurovascular features

Vascular dysfunction in the brain is a leading risk factor for dementia and neurodegeneration. However, brain vascular pathology is difficult to recapitulate in an animal model without influencing other aspects of disease. Thus, it remains challenging to understand how specific insults lead to brain vascular pathology and how the subsequent changes to vascular function mechanistically impact neurodegeneration. To complement animal models and help overcome these challenges, our lab develops engineered models of the vascularized human brain from combinations of human induced pluripotent stem cell (iPSC)‐derived progenies and primary tissue. We specifically focus on developing models that have: (1) neural organization and architecture similar to human cortex; (2) representative neurovascular features.