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The In Vitro Effect of Estradiol and Testosterone on Iron‐Induced Lipid Peroxidation in Rat Brain and Kidney Tissues

Abstract: The effects of estradiol and testosterone on iron‐induced lipid peroxidation were compared in rat brain and kidney homogenates in vitro. Lipid peroxidation in the form of malondialdehyde (MDA) was evaluated by the measurement of thiobarbituric acid (TBA) reactive substances. Estradiol inhibited lipid peroxidation in both tissues studied in a dose‐dependent manner. The effect was five times stronger in brain than in kidney. Testosterone did not affect lipid peroxidation in either tissue. Estradiol‐induced inhibition of brain lipid peroxidation might contribute to the neuroprotective effect of estrogens.