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Genomic analysis of animal ureaplasmas by restriction endonucleases.

Chromosomal deoxyribonucleic acids of ureaplasmas isolated from various animals were analyzed by restriction endonucleases. Possible evicence for methylated bases at the 5'-CCGG-3'sequence in the Ureaplasma urealyticum chromosome was obtained. The DNA cleavage patterns revealed by agarose gel electrophoresis showed that the unspeciated animal ureaplasmas are distinct each other and from the two established species, U. urealyticum from man, and U. diversum from cattle. This indicates the marked genomic variation among the ureaplasmas originating from chimpanzees, marmosets, sheep, goats, dogs, cats, and chickens.