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An evaluation of peripapillar choroidal thickness in patients receiving systemic isotretinoin treatment

Abstract Purpose Oral isotretinoin (13-cis retinoic acid, 13-cis RA) was approved for severe acne treatment by the FDA in 1982. The ocular side effects associated with oral isotretinoin use are mostly dose-dependent. Numerous ocular pathologies affect peripapillary choroidal layer primarily or indirectly. Objective Evaluation of the peripapillary choroidal layer in the patients receiving oral isotretinoin therapy may aid in explaining the pathophysiology of ocular side effects. Methods In this study, peripapillary choroidal thickness was assessed in the patients receiving oral isotretinoin treatment via optical coherent tomography technique. Results Significant difference was found in the superotemporal and temporal areas. Conclusion Oral isotretinoin treatment may affect the thickness of the peripapillary choroidal layer.