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Microemulsion and Bovine Serum Albumin Nanoparticles (BSANPs) as Novel Hybrid Nanocarrier System for Efficient Multifunctional Drug Delivery.

The present study aims to: (I) to design the versatile MEs system for drug delivery; (II) to use the bovine serum albumin nanoparticles (BSANPs) for MEs system development; (III) to characterize the physicochemical properties, cytotoxicity and biocompatibility of the modified MEs (MMEs) system; (IV) to load of paclitaxel (PTX) and folate-conjugate of MEs system; and (V) to assess the potential of anticancer activity of MEs system. The physicochemical possessions, in vitro and in vivo cytotoxicity and stability of MMEs system were characterized. The results of our study, show that the MEs system was stable, having narrow particle size distribution, nontoxic, biocompatible and not active for leukocyte proliferation. So it can be concluded that the MMEs system as a promising candidate for a targeted multifunctional drug delivery system (PTX and folate) that is called a smart MEs system. This article is protected by copyright. All rights reserved.