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Diffusion Changes in Normal Pressure Hydrocephalus

The diffusion of water in the periventricular region is altered in hydrocephalic patients due to transependymal resorbtion of CSF. This fluid diftises away from the ventricular surface, producing increased extracellular water in the periventricular white matter (PVWM). The average diffusion constant (I),,) of the periventricular white matter in hydrocephalic patients is increased compared to normals (2). In this study, we tested the hypothesis that transependymal resorbtion of ventricular fluid may lead to edema throughout the brain not only in PVWM regions. We quantified the mean brain diffusion constant in NPH patients and make comparisons to age-matched normative values. Methods In this study, we retrospectively examined the MR images of 7 patients with NPH. Diagnosis was made on the basis of clinical and imaging findings. The age range of the patients is 22-84 years with a mean age of 54.2k21.3 years. The group of patients included 3