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AB0765 Identification of Neuropathic Pain Component in Patients of Various Age with Knee Osteoarthritis

Background Osteoarthritis-induced pain is a result of nociceptor stimulation, associated with local tissue damage and inflammation. Resent data suggest the presence of neuropathic pain symptoms in patients with osteoarthritis. Objectives The aim of this study was to estimate the structure of pain syndrome, reveal the presence of neuropathic pain (NP) component, symptoms and signs of NP in patients suffering from knee osteoarthritis. Methods We've examined 44 patients with knee osteoarthritis of the II-III stages by the Kallgrene-Lawrence scale aged 47–85 years (average age 66,1±1,5 years). Patients were divided according to age into next groups: 47–60, 61–74, 75–85 years. To assess the NP component, we used screening scales painDETECT, LANSS, DN4 questionnaires. To assess intensity of pain, visual analogue scale (VAS) was used. Besides WOMAC and EuroQol-5D questionnaire were applied. For statistical analysis of results, ANOVA, correlation and regression analysis, chi square (χ2) were applied. Results 72,7% of patients with knee osteoarthritis examined by painDETECT were unlikely to have the NP component, 22,7% might possibly, 4,6% – probably. LANSS scale: 25% were probably to have NP. DN4 scale: 31,2% probably had NP. Moderate to significant correlations were found between intensity of pain by VAS data and Neuropathic Pain Scales (painDETECT, LANSS, DN4) data (p<0,05). It was established than higher results of screening by painDETECT and DN4 positively correlate with a disturbance of physical function tested by WOMAC (p<0,05). PainDETECT data have moderate to significant correlations with EuroQol-5D questionnaire (p<0,01). Verbal descriptors as pins and needles, tingling, numbness and allodynia, pain from light touch which are revealed by 3 screening scales can significantly contribute to the likely neuropathic component in patients with knee osteoarthritis (p<0,05). Burning pain (p<0,01), pins and needles (p<0,05) can be associated with a more severe pain in patients with knee osteoarthritis. Conclusions Thus, in patients with osteoarthritis the pain syndrome may reveal NP features. Identification of these would promote a targeted treatment strategy. Disclosure of Interest None declared