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Chromosomal studies in patients taking phenylbutazone.

In course of investigating a family for another purpose, an elderly woman was found to have a high proportion of grossly damaged chromosomes. During the preceding 15 months she had been taking phenylbutazone for osteoarthrosis. She had never had any external or internal radiation therapy, and the only other drug shewas taking was a 50mg. nembutal capsule each night. As there was no obvious explanation of her chromosomal damage, and because phenylbutazone has long been suspected of occasionally causing blood dyscrasias, and possibly of being associated with leukaemia (Dougan and Woodliff, 1965), it was decided to examine the chromosomes of a series of patients who had been taking the drug. Findings in these patients and in controls, some preliminary results from testing patients before starting to take phenylbutazone, and at intervals thereafter, and some miscellaneous observations, including experiments in vitro, form the subject of this report.