{'fraction_non_alphanumeric': 0.036301369863013695, 'fraction_numerical': 0.012328767123287671, 'mean_word_length': 5.112970711297071, 'pattern_counts': {'":': 0, '<': 4, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Study of the Protective Effects of Dexamethasone on Ileum Mucosa Injury in Rats With Severe Acute Pancreatitis

Objectives: To study the protecting effects of dexamethasone on ileum mucosa injury of rats with severe acute pancreatitis (SAP). Methods: The SAP rats were prepared by improved Aho's methods. The plasma endotoxin and inflammatory mediators in serum were determined. The rat mortality, pathological changes of terminal ileum, nuclear factor kappa B (NF-&kgr;B), apoptotic indexes, and apoptotic related protein expression were observed. Results: The plasma endotoxin, inflammatory mediators, and NF-&kgr;B protein expression as well as pathological scores of the treatment group of ileum mucosa were lower than those of the model group at different time points. P selectin in model group significantly exceeded the dexamethasone treatment group at 3 and 6 hours (P < 0.01, P < 0.05). Caspase-3 protein expression in dexamethasone treatment group significantly exceeded the model group at 3 and 6 hours (P < 0.05), and apoptotic indexes were higher than those of the model group at 6 hours (P < 0.05), but Bax protein has shown no marked difference among groups. Conclusions: Dexamethasone can reduce the endotoxin level and inflammatory mediators and down-regulate NF-&kgr;B protein expression of ileum mucosa, and ileum mucosa epithelial cell apoptosis induction was involved as well. The tissue microarrays technique is of advantage in SAP study.