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Prostaglandin F1α Induced Stimulation of Rabbit Testicular Contractions in Vitro 1

Summary Excised rabbit testes were observed to contract autorhythmically in vitro at a frequency of 2-3 times/min. When PGF1a was added to the bathing media, an increase in rate and overall tone with a change in amplitude was observed. At lower concentrations of prostaglandin, the amplitude increased; but at higher levels (greater than 71 nM), amplitude was decreased. The response of the testicular capsule was dose dependent from 0.4 to 213 nM concentration of PGF1a. When PGF1a was added to a testicular preparation during the latent period, before contractions were initiated spontaneously, an overall increase in tone was observed at 14 nM concentration, and the appearance of contractions approximately 7 min after treatment. At 57 nM concentration, PGF1a initiated a series of modulated contractions within 1-3 min that increased in amplitude with time. The available data now suggest that prostaglandins may modulate testicular contractions in vitro: one group inhibiting and a second group stimulating this activity.