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Cognitive frailty: A pre‐dementia syndrome or a branch of healthy ageing?

There is a pressing need for new therapeutic strategies to arrest Alzheimer’s disease (AD) at its prodromal stage. MTL pathology at this stage causes widespread synaptic dysfunction, before any cognitive decline and atrophy. We propose that neurophysiological biomarkers sensitive to this early synaptic dysfunction could be recorded using electro‐magnetoencephalography (E/MEG). Cam‐CAN Frail study, investigates neurophysiological changes that occur in cognitively frail individuals, who show cognitive decline in the absence of a clinical diagnosis.