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A Case of Neonatal Transient Hyperthyroidism: In Both Infant and Mother, TSH‐binding Inhibitor Immunoglobulins (TBII) Positive and LATS Negative

We reported a case of neonatal transient hyperthyroidism in which TSH-binding inhibitor immunoglobulins (TBII) was detected in both of the mother and the infant . The mother was diagnosed of Basedow’s disease at 30 week’s gestation. The infant was clinically euthyroid at birth and was normal in the thyroid function tests of cord blood. On 10 days of age, fever and tachycardia were noted and thyroid function tests presented hypert hyroidism. Thus, propylthiouracil, propranolol and Lugol’s solution was given and then the baby recovered completely at 5 month of age. In this case, LATS was found in neither the mother nor the infant. TBII was strongly positive in the sera of the mother and the infant at 6 day of age and that of the infant was decreased at 24 day-old. But it was negative only in the infant at 69 day of age when clinical symptoms disappeared. Thyroid stimulating antibody (TSAb) was positive in the serum of the mother. In our case, it was suspected that transplacental transfer of TBII was considered to have a role in neonatal transient hyperthyroidism.