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Anxiolytic effect of noscapine in mice.

The anxiety-related effects of noscapine were investigated using male Balb-c mice. Since noscapine-induced locomotion may alter the animals' activity level in the dark-light model, the anxiety-related effects of noscapine were studied at doses with no effect on locomotion (0.1, 0.2, 0.3, 0.4, 0.5, 0.8, 1, 1.5 and 2 mg/kg). The parameter measured in dark-light model was the time spent in lit compartment. Intraperitoneal administration of noscapine (0.1-0.5 mg/kg) did not produce a significant effect on the time spent in the light, whereas higher doses (0.8, 1, 1.5 and 2 mg/kg) increased it significantly, implying an anxiolytic effect.