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Expression of E-cadherin in Nephroblastoma and its Clinical Significance

Objective: Our aim was to study the expression of E cadherin in nephroblastoma and its clinical significance. Methods: Immunohistochemical staining S P was used to detect E cadherin protein in 30 tissue samples of nephroblastoma and 11 tissue samples of the adjacent kidney. Results: In the tissue samples of nephroblastoma, positive rate was 26.7%, while in the tissue samples of the adjacent kidney, the rate was 90.9%. The difference was statistical(P0 01). Expression of E cadherin was negative in 3 cases with lymph node metastasis and 4 of diameters more than 4 cm. No relationship was found between expression of E cadherin and pathologic classification, clinical staging, prognosis. Conclusion: There is a lower expression of E cadherin in nephroblastoma.