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Bone marrow culture and autoradiography of IgA myeloma plasmocytes with intranuclear inclusion bodies.

Two cases of IgA myeloma, characterized by intranuclear inclusion bodies, stained positively with anti-IgA fluorescent conjugate and only faintly by the PAS method. Electron micrographs showed distension of the endoplasmic reticulum with accumulation of amorphous material of low electron density. The intranuclear inclusion bodies consisted of the same material, encircled by a single sheeted membrane, identical and sometimes continuous with the internal layer of the perinuclear membrane. Autoradiography of the bone marrow cells after incubation for different periods with 14C-leucine showed the appearance of the radioactive label, first in the cytoplasm, then on the perinuclear membrane, and finally in the inclusion bodies themselves. Bone marrow cultures showed progressive swelling of the inclusions resulting in the disruption of the cells. 
 
 
 
These findings confirm the opinion that intranuclear inclusion bodies originate from distension of the perinuclear cistern by accumulated immunoglobulin with subsequent invagination into the nucleus. The cases displayed a different clinical course despite the structural similarity of the intranuclear bodies.