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Cell-Cell and Cell-Extracellular Matrix Adhesion Molecules Communicate with Growth Factor Receptors: An Interactive Signaling Web

Abstract The review article by Weiner and Zagzag in this volume of Cancer Investigation highlights some of the more current data relating to the important interactions that can occur between cell surface growth factor receptor tyrosine kinases (RTKs) and the cell adhesion kinases (CAKs). This is an important biologic and clinical topic because oncogenic activation of RTKs, such as the epidermal growth factor receptor, c-erb B-2. or the fibroblast growth factor receptor-1, by gene amplification and/or by overexpression can lead to malignant transformation in vitro and is involved in the pathogenesis of several different types of human carcinomas (1,2). In addition. a decrease in cell adhesion is an initial prerequisite for engaging the initial stages of tumor cell invasion and metastasis. Selective therapeutic targeting of RTKs or effectors in the metastatic cascade have already shown to be effective in the treatment of some types of human tumors (3).