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Erythrocyte Production in Mice Infected by the Polycythaemia‐Inducing Friend Virus or by the Anaemia‐Inducing Friend Virus

Summary. The changes induced by infection with the anaemia‐inducing (FVA) or the polycythaemia‐inducing (FVP) strain of Friend virus on PCV, RBC, reticulocyte counts, red‐cell and plasma volume and reticulocyte maturation time were studied in Swiss mice for 7 weeks after viral infection. The data indicated that the increase in total blood volume is mainly due to the augmentation of the spleen and liver blood volume in FVA‐disease, whereas it results from the large numbers of red cells produced by the spleen in FVP‐disease.