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New Histological and Physiological Stains Derived from Diffusion‐Tensor MR Images

The measurement of the self-diffusivity of water (and other solvents) using the phenomenon of nuclear magnetic resonance was first reported more than four decades ago. Methodological improvements in these diffusion measurements2 and the subsequent development of magnetic resonance imaging,' together created the possibility to measure diffusion properties of water in tissues on a voxel by voxel basis. Diffusion imaging (DI), which was first realized in 1985,4-6 consists of measuring an apparent diffusion constant (ADC)7 in each voxel. Both its theoretical underpinnings and its applications are well-known and are described in a number of excellent books and review