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Role, indications, and controversies of antidepressant therapy in chronic stroke patients.

Antidepressants are a heterogeneous class of drugs that have been developed for the treatment of mood disorders. In the past several years, they have been used in poststroke survivors to treat poststroke depression, central poststroke pain, and poststroke fatigue and as an adjuvant for functional recovery and cognitive function. However, there are still some relevant points to clarify regarding the real role of antdidepressants in stroke patients and further researches are needed to deeply explore their effects on rehabilitation results.