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LONG TERM CONTROL OF GROWTH RATE AND BONE MATURATION BY LH RH AGONIST IN GIRLS WITH TRUE PRECOCIOUS PUBERTY (TPP)

TPP reduces adult height. During its first year of administration, the LH RH agonist D-Trp6 (Decapeptyl®) decreased growth velocity and bone maturation, but its long term effects have not been analyzed. Fourteen girls had onset of idiopathic TPP at 6.3±1.2 yrs: their growth rate was 9.7±3.5 cm/yr and bone age 8.9±1.9 yr. The girls received 1 injection/mo of a depot preparation of the agonist during 4.8±1.2 yrs. Growth rate stabilized at 4±1.2 cm per yr (p<0.005 vs pretreatment) and bone age increased by only 0.85±0.15 yr/yr. At the end of treatment, height was 151.5±6.2 cm and bone age 12.3±0.6 yrs. Growth rate remained at 4.4±2 cm/yr during the following 6-34 months. Therefore, 7±1.3 yrs after the onset of treatment with the LH-RH agonist, height was 157±8 cm and bone age 13.2±1.1 yrs, producing a final height prognosis of 162±5 cm. We conclude that treatment of true precocious puberty with D-Trp6-LH-RH increases final height prognosis.