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Electrospun Ag/PMA Nanofibrous Scaffold as a Drug Delivery System



Polymers play a key-role in the drug delivery technology. They allow for the
controlled release of therapeutic agents under an external stimulus if a sensitive segment is suitable incorporated
in the polymer matrix. Actually, polymer capsules containing noble metal nanostructures
are regarded as promising light-responsive drug carriers. Among polymers, poly(methacrylic acid),
PMA, offers manifold advantages: i) solubility in water, ii) coordination ability for Ag-Au nanoparticles,
and iii) ability to act as capping agent. However, the preparation of Ag/PMA nanocolloids involves
complex procedures the use of reagents with severe environmental impact.



 The goal of this work is to develop Ag/PMA nanocolloids for the controlled release of the
encapsulated therapeutic agent (Sorafenib Tosylate) through a simple and cost effective synthesis process
and the use of biocompatible, implantable materials. The light- and heat-responsiveness of fibrous
scaffolds of Ag/PMA nanocolloids produced by electrospinning is investigated and compared
with that of Ag/PMA nanocolloids.



The goal of this work is to develop Ag/PMA nanocolloids for the controlled release of the
encapsulated therapeutic agent (Sorafenib Tosylate) through a simple and cost effective synthesis process
and the use of biocompatible, implantable materials. The light- and heat-responsiveness of fibrous
scaffolds of Ag/PMA nanocolloids produced by electrospinning is investigated and compared
with that of Ag/PMA nanocolloids.



In both the investigated systems, Ag/PMA nanocolloids and electrospun scaffolds of
Ag/PMA nanocolloids, the drug release is significantly favored by the considered stimuli. Upon heat
stimulus, Ag/PMA nanocolloids provide greater cumulative drug release with respect to the electrospun
scaffold. Conversely, upon light stimulus, the scaffold is able to release a larger amount of Sorafenib
at a faster rate, thanks to the Ag-mediated laser irradiation heating effect.



The electrospun fibrous scaffold of Ag/PMA nanocolloids is demonstrated to be an efficient
system for the remotely-triggered delivery of drug in a target area. The values of its loading efficiency
(60%) and drug content (5.5%) are comparable to the ones obtained from amphiphilic copolymer
structures prepared via complex chemical procedures with the use of toxic solvents and surfactant
to stabilize the nanocolloids.
