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Divergent effects of infused progesterone on the reflexive release of oxytocin in ovariectomized goats variously treated with 17beta-estradiol.

Progesterone, infused for 30 and 60 min at 50 µg/min, was found to reduce significantly the amount of oxytocin released in response to vaginal distention stimuli in intact goats and in ovariectomized goats treated continuously with 17β-estradiol from the time of surgery. Identical infusions in goats not treated with estradiol following ovariectomy, however, failed to suppress the reflex. Indeed, the infused steroid actually enhanced die oxytocin-releasing response to vaginal distention stimuli. Subsequent estrogen therapy failed to revive the suppressive action of infused progesterone in these animals. Instead, a significant facilitative effect persisted. These findings suggest, first, that progesterone may have both an inhibitory and a facilitative mode of action on the oxytocinreleasing reflex in intact goats and, second, that the integrity of the inhibitory component may depend upon an uninterrupted exposure of the animal to estrogen. (Endocrinology94:1531, 1974)