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Induction in guinea‐pigs of airway hyperreactivity and decreased lung β‐adrenoceptor number by 15‐hydroperoxy‐arachidonic acid

Administration to guinea‐pigs of 15‐hydroperoxy‐arachidonic acid (0.2 mg kg−1 i.p.) caused a 20% reduction of lung β‐adrenoceptor number. Furthermore, in vivo, a hyperreactivity of the airways to nebulized histamine was observed. In contrast, administration of 15‐hydroxy‐arachidonic acid (0.2 mg kg−1 i.p.) did not cause a significant change in either of these parameters.