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The Biological Variation of C-reactive Protein in Polycystic Ovarian Syndrome

lated to be the dose in the equation with a total CV of 20%. We found the functional sensitivity, using reagent lots 26 and 29, to be 0.012 mIU/L. This value is considerably lower than that of Rawlins and Roberts (1 ), although the same reagent lots were used. For the two newer in-date lots, functional sensitivity was calculated to be 0.022 mIU/L. Both determinations are consistent with the manufacturer’s claim of 0.019 mIU/L for the ADVIA Centaur TSH-3. In summary, we believe that the data support our functional sensitivity claim for the third-generation ADVIA Centaur TSH-3 method and that this claim has been demonstrated in other studies (4–6).