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[PP.29.12] RELATION BETWEEN ARYLESTERASE ACTIVITY AND PULSE PRESSURE IN PATIENTS WITH A ISCHEMIC STROKE

Objective: Stroke is a multifactorial disease arising from genetic andenvironmental risk factors or their interaction. The underlying cause of the majority of ischemic strokes is an atherosclerotic plaque in the carotid arteries. Oxidative stress and blood pressure were found to be closely related with cardiovascular and cerebrovascular diseases. Oxidative modification of serum low density lipoproteins (LDL) in the arterial wall is considered to be an important early step in the development of atherosclerosis. Paraoxonase-1 (PON1) has been considered as an anti-atherosclerosis factor, because it can reduce the oxidative modification of lipoproteins and macrophage foam cell formation occurring in the early phase of atherosclerosis. Therefore, it is easily inferred that the changes in serum PON1 concentrations or activity can affect vascular disease status. Arylestarase (ARE) is considered as the main protein indicator which is not affected by changes in PON1. Elevated pulse pressure may lead to an increased risk of cardiovascular and cerebrovascular morbidity and mortality. We investigated the association between Arylesterase (ARE) activities and pulse pressure (PP) in ischemic stroke patients. Figure. No caption available. Design and method: We evaluated and compared the ARE activity and PP in 46 ischemic stroke patients and 32 control patients. They were classified into 2 groups: Ischemic stroke patients (Group 1, n = 46), control patients (Group 2, n = 32). Blood pressure measurements were performed in all patients within 10 minutes admitted to emergency care unit. The PP was calculated by subtraction of diastolic blood pressure (DBP) from systolic blood pressure (SBP). Student t test and Chi-square analyses were used to compare differences between groups. Results: Hypertension, age, diabetes mellitus, dyslipidemia signficantly higher in ischemic stroke patients than control group (Table 1) (p < 0.05). PP was significantly higher in ischemic stroke patients than control group (48.12 ± 15.42 and 39.46 ± 12.56, p < 0.05). ARE activity was significantly lower in ischemic stroke patients than in control group (521,88 ± 72,49 and 577,99 ± 87,51, p = 0.016). Conclusions: Our results suggested that, ARE activity and PP are important risk factors in ischemic stroke patients.