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Correlation between Serum Amyloid A-Low Density Lipoprotein and Genotoxicity in Smokers.

OBJECTIVE
To investigate the relation between serum amyloid A-low density lipoprotein (SAA-LDL) and genotoxicity in smokers.


STUDY DESIGN
An experimental study.


PLACE AND DURATION OF STUDY
Army Medical College, Rawalpindi and National Institute of Health (NIH), Islamabad, from June 2014 to February 2015.


METHODOLOGY
Seventy healthy Sprague Dawley rats were purchased from NIH and exposed to cigarette smoke in smoke chamber for three months. Blood samples were drawn from each rat at the end of the study period. SAA-LDL was determined by enzyme-linked immunosorbent assay (ELISA). Genotoxicity was assessed by cytokinesis block micronucleus (CBMN) assay. Pearson correlation was used to find correlation between SAA-LDL and genotoxicity.


RESULTS
Strong positive correlation was found between SAA-LDL and micronuclei frequency in smoke-exposed rats (r=0.799, N=70, p <0.01).


CONCLUSION
Statistically significant strong positive correlation between SAA-LDL and genotoxicity in smoke-exposed rats shows that changes in one is associated with changes in other and vice versa.