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[Control of bone metabolism by central nervous system].

It has been believed that bone is controlled by local environment through the action of hormone and cytokines, independently of other organs. However, the discovery that leptin regulates bone formation through the central nervous system shed light on a new regulatory system of bone metabolism, i.e., neuronal control. Moreover, recent discovery that osteocalcin regulates glucose metabolism and fertility clearly demonstrated that bone forms a regulatory network of metabolism, together with other organs.