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Neurofibrillary tangles in ALS and parkinsonism–dementia complex focus in Kii, Japan

Brains of 41 residents without neurodegenerative diseases in the high-incidence area of ALS/parkinsonism–dementia complex (ALS/PDC) of the Kii Peninsula of Japan were neuropathologically examined. Neurofibrillary tangles (NFTs) in the hippocampal area were present in 11 of the 41 cases, but the frequency of NFT-positive cases in each age group was similar to that of the normal Japanese population and far less than that of Guamanians without ALS/PDC.