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[Reactions of granulation tissue fibroblasts in regenerating skin to chronic hypoxia].

An investigation of the effect of chronic hypoxia on fibroblasts of the granulation tissue of a regenerating wound showed that an appreciable portion of fibroblasts degenerated and died. Some of the cells retained their capability to synthesize collagen but its excretion outside the cell was disordered. It also demonstrated an inhibition of fibrillogenesis and thus delayed regeneration of an experimental lesion.