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FORMULATION OF A CREAM CONTAINING ETHOSOMAL GREEN TEA (CAMELLIA SINENSIS L. KUNTZE) LEAF EXTRACTS FOR IMPROVED DERMAL PENETRATION

Objective: This study aimed to formulate the epigallocatechin gallate (EGCG) from green tea into ethosomes and measure the resulting increases inskin penetration using a rat model.Methods: Ethosomes were formulated using ethanol concentrations of 25% (F1), 30% (F2), and 35% (F3), and those with favorable characteristicswere then incorporated into a cream for the determination of penetration into Franz diffusion cells.Results: We showed that the formulation F3 had the best spherical morphology, a Z-average value of 73.01 nm, a polydispersity index of 0.26, azeta potential of −47.77±3.93 mV, and the highest percentage of drug entrapment (49.46%±0.62%) compared with the other formulas. The totalcumulative EGCG penetration from the resulting ethosomal cream was 905.75±49.47 μg/cm2, whereas that from the cream containing green tea leafextract was only 413.92±52.83 μg/cm2.Conclusion: These data indicate a higher penetration of EGCG from ethosomal green tea cream than from cream containing non-ethosomal green teaextract.