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Ability of a new infant formula prepared from partially hydrolyzed bovine whey to induce anaphylactic sensitization: evaluation in a guinea pig model

In the present study we evaluated the allergenicity and immunogenicity of a whey partially hydrolysate formula (PHF) in a guinea pig model. Nine groups of 10 guinea pigs received either a conventional milk formula (CMF) or PHF for 37 days. After intravenous (i.v.) challenge with either α‐lactoglobulin (β‐L) or ultracentrifuged (u)CMF, animals fed CMF showed, respectively, 80% and 100®0 fatal reactions, whereas animals fed PHF showed no reactions when i.v. challenged both with (3‐L and uPHF. Eighty percent fatal reactions, and 10%, respectively, of severe and mild reactions have been observed in the CMF‐fed, casein‐challenge group. In contrast, only one (10%) mild reaction occurred in the PHF‐fed, casein‐challenged group. When challenged with u‐pasteurized cow's milk (uPCM), CMF‐fed animals showed 86% fatal reactions and 14% mild reactions, whereas PHF‐fed ones presented 70% no reactions, 20%, mild reactions, and one (10%) fatal reaction. Animals fed CMF showed a significantly higher level of specific IgG against cow's milk antigens than PHF‐fed ones, which, however, presented higher levels of antibodies than a water‐supplemented control group. The present results confirm that PHF is less sensitizing than CMF in a guinea pig model.