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COMPARATIVE ANALGESIC ACTIVITY OF SELECTED SOLANUM SPECIES

Synthetic analgesic drugs have prominent side effects like gastritis, gastric ulcer, kidney disorder and cardiac arrhythmias. The genus Solanum has been primarily used for various therapeutic effects, mainly analgesics, in the indigenous system of medicine. The current research aimed to investigate and compare the analgesic activities of methanolic extracts of leaves of Solanum indicum, Solanum surattense and Solanum torvum. Using acetic acid induced writhing method and hot plate method, the analgesic activity was evaluated. Significant anti-nociceptive effects were observed on both animal models after the application of different doses of the extracts of Solanum species. The results exhibited that MESI, MESS and MEST at a dose of 200 and 400 mg/kg produced analgesic effects equivalent to diclofenac (10 mg/kg). However the extracts at 400 mg/ kg exhibited more pronounced analgesic activity. The results of this study demonstrated that the analgesic effects of all the three species were significant to each other and validate the traditional use of the plants of this Genus for the treatment of pain.