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Use of hyaluronic acid for regeneration of maxillofacial bones: A review

Purpose: Hyaluronic acid (HA) has been used widely in medicine and is currently of particular interest to maxillofacial surgeons. Several applications have been introduced, including those in which HA is used as a scaffold for bone regeneration both alone and in combination with other grafting materials to enhance bone growth.
This review aims to analyze the available literature on the use of HA for maxillofacial bone augmentation for prosthetic-driven implant placement procedures. This article also aims to review the specific advantages, applications, and graft materials associated with HA use.
Materials and Methods: Medline and PubMed databases were searched for relevant reports published between January 2000 and December 2021.
Results and Discussion: Nine publications describing the use of HA to augment bone volume were identified.
Administration of HA facilitates surgical manipulation of the graft and promotes osteoblast activity that stimulates bone regeneration and repair.
Conclusion: Although further studies are needed, these findings are encouraging, as they suggest that HA might be used effectively together with additional graft materials in maxillofacial bone augmentation procedures.​