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Metastatic Carcinoma in Effusions: Query Primary Site

Metastatic carcinomas to the pleura, pericardium, or peritoneum may be the first manifestation of an underlying malignancy. In those instances, the presumed primary site may be accurately suggested based on the cytomorphologic features of the malignant cells in the effusion, along with clinical data and ancillary studies (most commonly immunocytochemistry).