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MATERNAL PLASMA OESTROGEN AND PROGESTERONE LEVELS DURING THERAPEUTIC ABORTION INDUCED BY INTRA‐AMNIOTIC INJECTION OF PROSTAGLANDIN F2α

Plasma 17β‐oestradiol, total unconjugated oestrogens and progesterone levels were measured in ten patients in the second trimester of pregnancy who were undergoing abortion by intra‐amniotic injection of prostaglandin F2α (PGF2α). The correlation between total unconjugated plasma oestrogens and 17β‐oestradiol was highly significant (r =+0.92; p<0.001). A similar positive correlation between total unconjugated plasma oestrogen and progesterone was observed (r =+0.66; p<0.001). The concentration of these steroids in samples, taken at intervals during normal pregnancy, showed considerable variation. Following administration of PGF2α no consistent change was seen in plasma steroid concentrations until after delivery of the fetus and placenta. PGF2α therefore appears to have no direct effect on oestrogen and progesterone biosynthesis and may act principally by direct stimulation of myometrial contractility.