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Adequate vitamin B‐6 is associated with increased antioxidant enzyme activity in critically ill surgical patients

Inadequate vitamin B‐6 status may increase oxidative stress and compromise antioxidant capacity. The purpose of this study was to understand the association between vitamin B‐6 status and oxidative stress, antioxidant enzyme capacities in critically ill surgical patients. Patients were allocated into either adequate B‐6 (n = 11) or deficient B‐6 (n = 10) group based on their fasting plasma pyridoxal 5′‐phosphate (PLP) concentration at admission to the surgical intensive care unit (SICU). Plasma and erythrocyte PLP, serum malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione S‐transferase (GST) and glutathione peroxidase (GPx) were determined on the 1st, 4th, 7th and 10th d of admission. There was no significant difference in TAC and MDA levels, GST and GPx activities between the 2 groups on the 1st, 4th, 7th and 10th in the SICU. The mean SOD activity level was significantly higher in the adequate B‐6 group when compared to the deficient B‐6 group on the 1st and 4th after admission. The change of plasma PLP (rs = 0.68, p < 0.01) significantly correlated with the change of SOD activities after adjusting for potential factors. Higher plasma PLP at admission would be an important contributing factor to increased antioxidant enzyme activity in SICU patients. This study was supported by Taichung Veterans General Hospital (TCVGH‐994101B), Taiwan.