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Limited influences of chemotherapy on healthy and metastatic liver parenchyma.

AIM
To examine the expression of E-cadherin, beta-catenin, gamma-catenin, VEGF, and p53 in 39 patients with hepatic metastasis from colorectal cancer immunohistochemically.


METHODS
The patients were divided into two groups: those (n = 16) who had no chemotherapy for at least 6 mo before the liver resections and those (n = 23) who were treated with chemotherapy before liver resections. A score from 0 to 3 was given for the number of positive cells and from 0 to 3 for the intensity of staining in these cells, in both healthy and metastatic liver parenchyma.


RESULTS
No significant differences in the expression of E-cadherin, beta- and gamma-catenin, VEGF and p53, could be observed between patients who received and did not receive chemotherapy, in both normal and metastatic liver parenchyma.


CONCLUSION
Despite the assumption that chemotherapy had an effect on liver metastasis, no influences were noticed immunohistochemically.