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Metabolic Requirements for Sodium Transport in the Rat's Ileum 1

Summary The glucose dependent stimulation of Na transport in the ileum of the rat could not be duplicated with glycerol or pyruvate in an in vitro everted sac, although the latter 2 substrates were metabolized by the ileum to CO2 at a faster rate than glucose. Galactose stimulated Na transport, provided that an energy source was available for the movement of this hexose. This glucose dependent increment of QNa resulted primarily from the metabolism of glucose which did not occur by glycolysis, Krebs cycle activity or oxidative phosphorylation, and secondarily from the active transport of a hexose.