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Spectral analysts of ventricular fibrillation: validation of an experimental model

The present study analyzes three aspects related to Ventricular Fibrillation (VF): 1) Stability of the VF model using an isolated heart and maintaining perfusion; 2) Comparison among the information related to the spectral analysis of the VF signal given by different types and positioning of the electrodes during its stability; 3) Alterations in VF before its interruption provoked by administering ClK. The absolute (AAPM) and normalized (ANPM) amplitudes, the frequency for the maximum peak (FPM) and the energy contained in a band of /spl plusmn/1 Hz around the FPM are analyzed for a group of 25 registers. The conclusions are: 1) VF stability in isolated heart; 2) similar information respect to the FPM and the energy is obtained for unipolar and bipolar, endo- and epicardial electrodes during stable VF; 3) Progressive reduction in the FPM is appreciated following the administration of ClK.