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The effect of UV irradiation and photochemotherapy (PUVA) on histamine weal and flare in human skin

It is recognized that ultraviolet light has a beneficial effect in various inflammatory disorders of the skin. We have used histamine weal and flare as a model testing the effect of ultraviolet light on vascular response. No difference in weal and flare reaction following intradermal injection of 0·01‐10·0 μg of hisiamine was found between covered and exposed skin following UV radiation or photochemotherapy (PUVA).