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P1046GENDER DIFFERENCES IN CORRELATIONS BETWEEN THE LEVEL OF NT-PROBNP AND PLATELET PARAMETERS IN PATIENTS WITH EARLY DIABETIC NEPHROPATHY AND CHRONIC HEART FAILURE


 
 
 Many studies have shown that platelet parameters represent important markers of cardiovascular risk, but the data on gender differences are limited. In this study, we aimed to assess correlations between the level of NT-proBNP and platelet parameters in men and women with early diabetic nephropathy and chronic heart failure.
 
 
 
 We investigated 65 patients with type 2 diabetes who also had chronic kidney disease (stage 1-3) and chronic heart failure (42 women and 23 men). eGFR was calculated using CKD-EPI formula. In addition to routine clinical tests, we assessed mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW) and serum levels of NT-proBNP and erythropoietin. Mann-Whitney U-test and Spearmen’s correlation coefficient (rs) were used for statistical analysis.
 
 
 
 Mean levels of NT-proBNP were similar in men and women: 1019±267 and 1192±176 pg/ml (p>0.05), respectively, and there were no significant differences in platelet count, MPV, PCT and PDW between the groups. In women platelet indices were not related to age, body mass index, GFR, erythropoietin and hemoglobin levels, while in men PDW was positively correlated with body mass index (rs=0.600, p=0.009) and hemoglobin level (rs=0.506, p=0.021). Only in the female group serum level of NT-proBNP was interconnected with platelet count (rs= -0.419, p=0.006) and plateletcrit (rs= -0.559, p<0.001). Both in men and in women serum concentration of NT-proBNP was not correlated with the values of MPV and PDW.
 
 
 
 The results of the study suggest that platelet count and plateletcrit are negatively correlated with serum level of NT-proBNP in women, but not in men with early diabetic nephropathy and chronic heart failure. Further studies are needed to clarify clinical implications of these findings.
