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Analysis of coronary blood flow interaction with myocardial mechanics based on anatomical models

This is a review of the current state of data, methodologies and models available for the construction of an anatomically accurate, three–dimensional coronary vasculature in a dynamic model of the beating heart that integrates vascular morphology, blood-vessel elasticity and tissue mechanics. The model is discussed in relation to the Cardiome, an anatomically based integrated model of cardiac function.