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CeCl3·7H2O Catalyzed, Microwave-Assisted High-Yield Synthesis of α-Aminophosphonates and their Biological Studies

Abstract A new class of diethyl(3,5-dibromo-4-hydroxyphenylamino) (substituted phenyl/heterocyclic) methylphosphonates 4(a–j) has been synthesized by one-pot three component simultaneous reaction (Kabachnik–Fields) of 4-amino-2,6-dibromophenol 1, substituted heterocyclic/phenyl aldehydes 2(a–j), and diethylphosphite 3 using a Lewis acid catalyst, CeCl3·7H2O (5 mol%) under microwave irradiation as well as conventional conditions. It was observed that microwave irradiation method is more facile, efficient, and advantageous with respect to reaction time and yields. The structures of all the synthesized compounds were supported by analyzing IR, 1H/13C/31P NMR, and mass spectral data. The synthesized compounds were screened for their in vitro antimicrobial and antioxidant activities. GRAPHICAL ABSTRACT