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Influence of Vehicles Used for Oral Dosing of Test Molecules on the Progression of Mycobacterium tuberculosis Infection in Mice

Preclinical evaluation of drug-like molecules requires their oral administration to experimental animals using suitable vehicles. We studied the effect of oral dosing with corn oil, carboxymethyl cellulose, dimethyl sulphoxide and Polysorbate-80, on the progression of Mycobacterium tuberculosis infection in mice. Infection was monitored by physical (survival time, body weight) and bacteriological (viable counts in lungs) parameters. As compared with water, corn oil significantly improved both the parameters whereas the other vehicles affected only physical parameters.