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Significance of Monoclonal Band in Cerebral Spinal Fluid.

Commentary on Significance of Monoclonal Band Cerebral Spinal This clinical case study discusses the use of cerebrospinal fluid (CSF) protein electrophoresis/immunofixation (CPEP/CIFE) to evaluate an individual with recurrence of multiple myeloma in the central nervous system (CNS-MM). Overall, the incidence of multiple myeloma external to bone marrow ranges from 3% (newly diagnosed) to 20% (initial appearance in recurrent disease). CNS-MM itself occurs in less than 1% of the cases and heralds a poor prognosis with an overall median survival of 8 months from onset. CNS-MM can appear in pachymeningeal (dural), leptomeningeal (pia/arachnoid) or intraparenchymal locations, isolated or in combination; myelomatous extension from the calvarium ( (cid:4) 10%/CNS-MM) has also been reported.