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Human pre-exposure rabies immunization with suckling mouse brain vaccine.

Since the development of non-encephalitogenic rabies vaccines (Koprowski et al., 1952; Peck et al., 1955), several studies have been carried out on human pre-exposure immunization (Anderson et al., 1960; Dieterich et al., 1961; Fox et al., 1957; Schnurrenberger et al., 1961, 1967; Tierkel & Sikes, 1967). In the light of these results, the WHO Expert Committee on Rabies (1966) has recommended this type of prophylaxis for high-risk personnel, such as laboratory personnel working with rabies virus, veterinarians, dog handlers, and field naturalists.