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A clinicopathological correlation study of cognitive status and senile plaques and neurofibrillary tangles in clinically well‐characterized individuals of extreme old age

We describe the distribution of senile plaques (SP) and neurofibrillary tangles (NFT) in a series of 34 brain specimens derived from 90+ year‐old individuals (see table below) who had been systematically evaluated for cognitive function with the final assessments expressed using the Clinical Dementia Rating score (CDR; mean 2.62, SD ±1.27, range 0–5). We determined the extent of SP as a mean density of 5 neocortical areas and of NFT using aggregate density assessments in neocortex, hippocampus and entorhinal cortex. Due to the relatively small sample, we grouped the cases into normal to mild/moderate dementia and severe dementia as follows, and used the Wilcoxon Two‐Sample Test to compare the two groups.