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MPL W515L mutation in pediatric essential thrombocythemia

Essential thrombocythemia (ET) is extremely rare in the pediatric population. In most patients no molecular abnormality can be found, with about 40% of pediatric patients harboring a JAK2 V617F mutation. Another recurrent mutation, involving a W to L or K transversion at MPL codon 515, has been reported in about 3–8% of adult ET patients. Herein we describe this mutation in a pediatric patient. Pediatr Blood Cancer 2013;60E52‐E54. © 2013 Wiley Periodicals, Inc.