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CD5+ B cells and uveitis

High levels of circulating B1a lymphocytes expressing CD5 have been reported in some patients with non-organ-specific autoimmune diseases, such as systemic lupus erythematosus, primary Sjogren’s syndrome, and rheumatoid arthritis, although CD5+ B cells do not seem to be only agents of autoantibody production.1 Thus, B cells display a variety of characteristics other than antibody production—for example, in lymphoid architecture development, regulation of T cell subsets and antigen presenting cell function through cytokine production, and in activation of T cells.2,3 In addition, CD5+ B cells have a role in several organ-specific autoimmune diseases, such as chronic urticaria,4 insulin dependent diabetes mellitus,5 myasthenia gravis,6 and immune thrombocytopenic purpura, where the increased proportion of CD5+ B cells in spleen and peripheral blood, and …