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REPERFUSION FOLLOWING GLOBAL ISCHEMIA: CORONARY FLOW DISTRIBUTION WITH BLOOD VERSUS PERFLUOROCHEMICAL

Unique rheological properties of perfluorochemical emulsions (PF), i.e. smaller particle size and lower viscosity, may improve the distribution of coronary flow following global ischemia. Thus we compared the effects of reperfusion with blood (n=6) and PF(n=6)following 30 minutes of global ischemia, in the isolated perfused (constant flow) rabbit heart. We measured endocardial/epicardial flow ratios (EN/EPI) coronary resistance (RES), and recovery of contractile function (dP/dT), 10 and 120 minutes after global ischemia. All hearts were perfused with blood prior to ischemia. Results are shown in the table. Values are expressed as % of pre-ischemic measurement ± SEM.Ten minutes following ischemia, coronary resistance and EN/EPI ratio decreased with blood while both parameters increased with PF reperfusion. By 120' post-ischemia, EN/EPI ratio and contractile function were greater with PF compared to blood reperfusion. Thus, reperfusion of the globally ischemic heart with PF may improve functional recovery due to greater endocardial flow. We speculate that this is mediated by the smaller particle size and lower viscosity of PF compared with blood.