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[Changes in lipid metabolism in the myocardium as one of the possible mechanisms of the development of the overload form of heart failure].

In addition to hypertrophy of the myocardium, there are changes in its lipid composition as evidenced by activated lipid peroxidation, lower quantities of unsaturated fatty acids, and higher amounts of saturated phospholipids and lysophospholipids in overload heart failure induced by aortic coarctation. The derangement of the lipid environment may contribute to a decrease in the powerful capacity of membraneous enzyme systems, disturbances in ion transport and cardiac diastolic relaxation, which is one of the causes of heart failure.