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The role of IQGAP1 in transendothelial migration: from in vitro identification to in vivo validation

Although inflammation is the body's stereotyped response to tissue damage, the clinical outcomes of this complex process, whether beneficial or detrimental, are rooted in the recruitment and subsequent function of the leukocytes at site of insult. It therefore follows that the regulation of leukocyte recruitment represents an acutely tractable target for therapeutic intervention. In order to reach the target tissue, leukocytes must undergo a carefully choreographed series of sequential intercellular interactions with the endothelium which culminate in transendothelial migration (TEM). As the leukocyte prepares to traverse the endothelial cell layer requisite protein‐protein interactions between the two cells directs the recruitment of the endothelial cell sub‐junctional Lateral Border Recycling Compartment (LBRC). Several of the endothelial proteins crucial for this process reside in the LBRC and its function in TEM is required for efficient leukocyte efflux.