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The Influence of T Cells on Homogeneous Immunoglobulins in Sera of Athymic Nude Mice during Aging

In this study, results are presented which are in agreement with predictions made on basis of the ‘three‐Stage hypothesis’ on the development of benign monoclonal gammapathy (BMG). In a T‐cell depletion model, C57BL/Ka nude mice were shown to develop single and multiple homogeneous immunoglobulins (H‐Ig) during aging in the highest frequencies known so far. Ninety percent of the C57BL/Ka nude mice displayed one or more H‐Ig at 12 months of age. In a T‐cell supplementation model, infusion of corticosteroid resistant T cells into 9‐month‐old BALB/c nude mice resulted in a decrease in the Frequency of H‐Ig from 43% at 9 months down to 20% at 15 months of age. In contrast, the frequency of H‐Ig in the control group increased from 40% at 9 months up in 68% at 12 months. The results show that normally functioning T cells are essential for the generation of a normal, heterogeneous Ig spectrum; they further support the validity of the three‐stage hypothesis with regard to the role of an impairment of the T immune system in the pathogenesis of BMG.