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Nifedipine for epilepsy? A pilot study

Theoretical considerations suggest that blockers of calcium channels may have anticonvulsant activity, and this has been confirmed in seizure models in vitro' and in vivo.2 Results with the sedative flunarizine in humans have been promising.3 The conventional calcium antagonists verapamil and diltiazem have been found to inhibit the biotransformation ofcarbamazepine and produce neurotoxicity.45 In this pilot study we assessed the antiepileptic potential of nifedipine, a dihydropyridine derivative.