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[Prevention and therapeutic strategy of metabolic syndrome--implications from the interim results of Japan Diabetes Complications Study(JDCS)].

Type 2 diabetes plays significant roles in pathogenesis of metabolic syndrome. The Japan Diabetes Complications Study(JDCS) is an ongoing trial with 2,205 patients with type 2 diabetes. It is clarified that the frequencies of CHD and stroke events in type 2 diabetic patients are three or more times greater than non-diabetic subjects. Gender, LDL cholesterol, glycohemoglobin A1c and triglycerides are significant age-adjusted risk factors for CHD in patients with type 2 diabetes, while systolic blood pressure and glycohemoglobin A1c are those for stroke. We can conclude from these results that the control of risk factors like LDL cholesterol and blood pressure, together with glycemic control, is essential for preventing CHD and stroke also in Japanese patients with type 2 diabetes.