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Nanoformulations can be utilized to deliver effective siRNA to tumor cells to decrease gene expression

siRNA-based gene therapy has gained interest in recent decades. Nanocarriers can be used to deliver rapid and efficient siRNA to tumor cells, suppressing gene expression. Some RNAi-based therapies are presently undergoing clinical trials. Clinical trials to preserve and distribute siRNA are increasingly focused on nanoformulations, and their safety has been promising. How nanocarriers avoid immune clearance and extend their circulation in the body is a key study topic for scientists.Most research relies on EPR-mediated passive targeting. However, as the MPS system sequesters most nanocarriers, the E PR effect can not be administered successfully in mice, which is a big human concern. Novel targeted approaches are desperately needed to accumulate siRNA in tumor tissues. In vitro and animal models, a number of TME-responsive siRNA nanocarriers were examined. Clinical nanomedicine is generally simple in structure and easy to mass-produce while preserving safety and effectiveness.It will require the collaborative efforts of materials scientists, basic medical scientists, and clinicians to develop the design of the ideal siRNA delivery vector, the authors suggest. The authors suggest that multimodal combination therapy has a stronger therapeutic impact on malignancies than a single therapy paradigm and might be "over-designed" for therapeutic usage. The study was published in Cancer Research.