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Highly efficient electrosynthesis of nitric oxide for biomedical applications.

Nitric oxide (NO) constitutes one of the most versatile therapeutics for biomedical applications because of its manifold signaling functions. The efficient and on-demand generation of NO essentially dictates its concentration dependent therapeutic activity. Here, we report an electrochemical system employing a rationally designed single-iron atom based biomimetic catalyst (i.e., Fe SAC), for high-efficient and controlled NO generation. The Fe SAC shows superior catalytic ability in electrochemical reduction of nitrite, with maximal rate of NO generation achieving 2.1 μM·(min·μg) -1 . DFT studies suggest the significant decrease of Gibbs-free energy of NO 2 - adsorption on single-iron atom accounts for its high catalytic efficiency. Moreover, ample amount of NO can be controllably generated in a potential dependent manner. Using bacterial elimination as a representative application, the electrochemical generated NO overwhelmingly disrupts gram-negative and gram-positive strains. The effectiveness of NO generation system underscores a great promise to expedite NO research in both basic and applied sciences.