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[Effect of different preoperative rehydration on sugar metabolism; comparison between Arginaid Water and OS-1].

BACKGROUND
Enhanced Recovery After Surgery (ERAS) program recommends carbohydrate load before surgery. However, the dose and dosing method of carbohydrate load are not clear. In this paper, effect of different preoperative rehydration on sugar metabolism in healthy volunteers is reported.


METHODS
Arginaid Water (ArgW) and OS-1 (OS) used as preoperative rehydration in Japan were employed for measuring sequential changes in sugar metabolism in blood. Both ArgW intake group and OS intake group started fasting at 9 PM. At 8 AM in the morning, respective preoperative rehydration 250 ml was taken as a bolus. Blood test was performed before intake, 30 minutes, 2 hours and 4 hours after intake.


RESULTS
Subject included 10 healthy volunteers for ArgW and OS respectively. Subjects drank each preoperative rehydration two hours before entering operating room. In ArgW intake group, free fatty acid (FFA) and beta-hydroxybutyric acid concentration (beta-OHB) were reduced and sugar metabolism was favorably maintained. Meanwhile, OS intake group, FFA and beta-OHB were elevated and catabolism of adipose began. However, even if ArgW were taken, rebound increases of FFA and beta-OHB were observed after entering operating room.


CONCLUSIONS
Optimum dosage and dosing method of preoperative carbohydrate should be scientifically verified in the future.