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Effect of different matrix metalloproteinase inhibitors on shear bond strength of composite attached to primary teeth dentin

Aim: This study is aimed to evaluate the effect of exogenous matrix metalloproteinases (MMPs) inhibitors on immediate shear bond strength (SBS) of resin composite attached to primary teeth dentin. Methods: Sixty extracted anterior primary teeth were selected. A dentin block (6.0 mm × 6.0 mm × 2.0 mm) was obtained from each tooth. All dentin blocks (n = 60) were pretreated for 60 s with either 0.01 M phosphate-buffered saline (pH 7.2) in the control group (Group I), chlorhexidine (CHX) 2% (Group II), doxycycline (DOX) solution 2% (Group III), and ethylenediaminetetraacetic acid (EDTA) 17% (Group IV) before applying etch-and-rinse adhesive system (Adper Single Bond 2). After adhesive application, composite resin (Filtek 3M, USA) was applied, and then, SBS values were determined with a universal testing machine. Results: There were no significant differences between SBS values of DOX, EDTA, and the control group (P < 0.05). SBS values reduced when CHX was applied, although the reduction was not statistically significant (P = 0.961). The DOX group showed the highest bond strength values (8.82 ± 3.29), which was significantly greater than the CHX (P = 0.026). Conclusion: Based on the results, pretreatment with MMPs inhibitors was not advantageous with regard to improving the immediate SBS of composite attached to primary teeth dentin.