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[Sequential evaluation of brain lesions using functional magnetic resonance imaging in patients with Leigh syndrome].

OBJECTIVE
To investigate the value of functional magnetic resonance imaging (MRI) in sequential evaluation of patients with Leigh syndrome.


METHODS
Two patients with Leigh syndrome underwent diffusion weighted imaging (DWI), perfusion weighted imaging (PWI) and proton magnetic resonance spectroscopy ((1)H-MRS).


RESULTS
The brain lesions showed hyperintensity on DWI, lactate doublet peak on MRS and hyperperfusion in the patients at baseline, and maintained a hyperintensity on DWI and hyperperfusion in the absence of lactate doublet peak on MRS at follow-up 1 year later. DWI still revealed persistent hyperintensity in the brain lesions in one patient 2 years later.


CONCLUSION
Functional MRI can sensitively highlight the characteristics of brain lesions in patients with Leigh syndrome, and can therefore be used to evaluate the sequential changes of the brain lesions.