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VDE‐initiated intein homing in Saccharomyces cerevisiae proceeds in a meiotic recombination‐like manner

Background: Inteins and group I introns found in prokaryotic and eukaryotic organisms occasionally behave as mobile genetic elements. During meiosis of the yeast Saccharomyces cerevisiae, the site‐specific endonuclease encoded by VMA1 intein, VDE, triggers a single double‐strand break (DSB) at an inteinless allele, leading to VMA1 intein homing. Besides the accumulating information on the in vitro activity of VDE, very little has been known about the molecular mechanism of intein homing in yeast nucleus.