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Pharmacokinetics of TGFβ with Emphasis on Effects in Liver and Gut

In this article we review our work on the disposition of systemically delivered TGFPI, a process in which the liver plays a major role. After a discussion of the pharmacokinetics of TGFP, we discuss the effects of acute and chronic administration of TGFS on hepatic regeneration following two-thirds hepatectomy (PH) in the rat. In addition, the potential role of TGFP in the growth and differentiation of the small and large bowel, as well as its effects on the growth of several human colon cancer cell lines, are discussed.