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The Arrangement of Microtubules in the Platelet Marginal Band

During thrombosis, platelets must undergo a drastic change in shape over a short period of time [1]. In their inactive state they are discoid, after activation, platelets become a tight circular shape and then flatten out to form larger aggregations [1]. Overall, platelet cell shape is regulated by two opposing forces generated by the cytoskeleton: 1) cortical tension generated by the cortical actin and 2) the rigidity of the circular band of microtubules known as the marginal band [2]. During this transition, the cell reduces in size and the rigid marginal band of microtubules coil [2].