{'fraction_non_alphanumeric': 0.026223776223776224, 'fraction_numerical': 0.0017482517482517483, 'mean_word_length': 5.897590361445783, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 1, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
[Development of radical reactions in water aimed at environmentally benign synthetic reactions].

The aqueous medium radical reactions of a variety of imine derivatives such as oxime ether, oxime, hydrazone, nitrone, and N-sulfonylimine were investigated. Triethylborane-mediated intermolecular alkyl radical addition to glyoxylic oxime ether, oxime, and nitrone in water proceeded smoothly to give alpha-amino acid derivatives in good yields. Alkyl radical addition to N-sulfonylimine proceeded in aqueous media using zinc as a radical initiator. The zinc-mediated radical reaction of the hydrazone with a chiral camphorsultam provided the corresponding alkylated products with good diastereoselectivities, which could be converted into enantiomerically pure alpha-amino acids. The indium-mediated radical reactions provide new opportunities for carbon-carbon bond formation such as alkylation reactions of imines and 1,4-addition to electron-deficient olefins. The indium-mediated tandem reactions also proceeded effectively via two carbon-carbon bond-forming processes for the preparation of various types of functionalized cyclic compounds.