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[Effect of T-lymphocytes on hematopoietic progenitors in patients with paroxysmal nocturnal hemoglobinuria].

OBJECTIVE
To study the effect of T-lymphocytes on hematopoietic progenitors in patients with paroxysmal nocturnal hemoglobinuria (PNH).


METHODS
Phytohemagglutinin-stimulating T-lymphocytes conditioned medium(PHA-TCM) prepared from PNH(PHA-TCM-PNH) and normal blood(PHA-TCM-N) was added to the cultures of PNH or normal CFU-GM and BFU-E.


RESULTS
In cultures containing PHA-TCM-PNH prepared from newly diagnosed PNH patients, the yields of CFU-GM and BFU-E from either PNH or normal bone marrow were reduced more than they did in cultures containing PHA-TCM-N; but in cultures containing PHA-TCM-PNH prepared from PNH patients in remission, they were normal.


CONCLUSION
T-lymphocytes from newly diagnosed PNH patients exerts an inhibitory effect on the in vitro growth of CFU-GM and BFU-E.