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Y6T-LYMPHOCYTES PHENOTYPE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES

YST-сells role in inflammatory bowel disease is still not fully investigated: on the one hand, they are thought to be involved in dysregulation of the immune response to gastrointestinal commensal bacteria in genetically susceptible individuals and, on the other hand, YST-cells may initiate repair of damaged intestinal epithelium and exhibit immunoreg-ulatory effects. The composition of T-lymphocytes subsets (авТ-cells, YST-cells) and the expression of functional molecules (TLR4+, CD314+, CD8+, CD45RO+) on circulating YST-cells in patients with inflammatory bowel disease were characterized in this study. An increase of YST-cells numbers predominantly expressing a cytotoxic phenotype along with a depletion of YST-cells memory population in peripheral blood of patients with Crohn’s disease and ulcerative colitis has been shown, what may reflect impaired tolerance mechanisms and results from chronic stimulation to autoantigens.