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Alterations in mRNA Translation Products Associated with Regenerative Responses in the Retina

Abstract: Translation products of mRNA from retinas of goldfish optic nerve (representing a regenerative CNS) and adult rabbit optic nerve (representing a nonregenerative CNS which can be induced to express regenerative characteristics) were examined by one‐ and two‐dimensional gel electrophoresis. Translation products from retinas of the regenerating goldfish optic nerve included polypeptides barely detectable in the translation products of mRNA derived from retinas of uninjured controls. Some of these polypeptides, of apparent molecular weights 24–28, 43–49, 60, and 65 kilodaltons can be considered as growth‐associated polypeptides described in other regenerative and developing systems. The induction of regeneration‐associated characteristics in the injured adult rabbit optic nerve, “implanted” with diffusible substances from nonneuronal cells of regenerative or growing nerve, is reflected by changes in the mRNA translation products of the retina. Among such translation products are those of the following molecular weights: 16–18, 28, 32–35, 43–47, and 56–60 kilodaltons, and some higher‐molecular‐weight species.