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The influence of amphotericin B upon Histoplasma infection in dogs.

A randomly assigned group of 51 mongrel dogs received a total intravenous dose of 1.85 mg of amphotericin B per pound of body weight over a 19-day period. The results of culture examination of lymph nodes for Histoplasma capsulatum were compared with similar cultures from a matched sample of 50 dogs who had received no drugs. A significant difference in infection rates as determined by culture was demonstrated indicating that amphotericin B is capable, at this regimen, of reducing such infection rates by at least 58% Thus, this method of therapy can be recommended as an important and perhaps necessary procedure for researchers utilizing dogs obtained from endemic histoplasma areas. Associations were " demonstrated between infection and the results of selected serological tests, with histoplasmin skin test readings, and with histopathologic findings.