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Recent Progress in Bio‐Integrated Intelligent Sensing System

It is incontrovertible that the bioelectronic enabled bio‐integrated system is one of the most promising technologies in the upcoming decades. Driven by the great versatility of the emerging artificial intelligence, machine‐learning‐supported bio‐integrated intelligent sensing system (BISS) is capable of achieving data processing and intelligent recognition while conducting multimodal human‐centered sensing; such facilitated systems capitalize the benefits of both bioelectronics and supporting algorithm, enabling accurate physiological/somatosensory recognition at the cost of certain computing resources. Herein, an overview of recent progress in BISS is presented, with an emphasis on high‐tech applications enabled by innovations in combining flexible bioelectronic sensors with supporting algorithmic systems. The main applications can be divided into three categories, including implantable, skin‐mounted, and wearable BISS, which have different requirements for materials, fabrication methods, and algorithms, respectively. Advances in these areas open new avenues for employing BISS as future human–machine interfaces for personalized healthcare, human enhancement, as well as other broad applications.