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Time Structure Of Cardiovascular Characteristics In Clinically Healthy Human Pregnancy

Blood pressure (BP) and heart rate (HR) were automatically monitored with a fully ambulatory noninvasive device at -1-hour intervals and for a total of 76 days in each of two consecutive pregnancies in a 31-year-old clinically healthy woman. Regression analysis of circadian parameters obtained by least-squares rthythmometry reveals patterns of variation of rhythm-adjusted means (M) and amplitudes (A) with gestational age, identical for both pregnancies. This double longitudinal study, carried out by the integration of available hardware for automatic BP monitoring with special software for the evaluation of cardiovascular characteristics, confirms and extends to ambulatory everyday life conditions the predictable pregnacy-associated variability in BP and HR and allows the establishment of prediction limits for cardiovascular parameters in the course of a healthy pregnancy, to be used in an early assessment of gestational hypertension or even preeclampsia.