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Subcutaneous nodules at progesterone injection sites after fertility treatment

Fertility treatment typically refers to medications that stimulate egg or sperm production or procedures that involve the handling of eggs, sperm, or embryos. If a woman has a luteal phase defect, the uterine membrane does not grow properly, which results in failed embryo implantation. Progesterone is used during infertility treatments to promote implantation and prevent miscarriage. It is commonly administered in two forms: vaginal administration and intra-muscular injections. Local injections of progesterone are largely considered to be safe, with the frequency of adverse effects being low. We herein report a case of fat necrosis that resulted in subcutaneous nodules after progesterone injections. A 40-year-old Japanese woman was referred with subcutaneous nodules on her buttocks. She had a history of infertility treated with HMG and hCG injections in her shoulder during the follicular phase, and progesterone injections in her buttocks during the luteal phase. A physi-