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miR‐186 suppresses cell proliferation and anchorage‐independence in a metastatic prostate cancer cell line

MicroRNA (miR) dysregulation alters the expression of cancer related genes and contributes to disease states in many cancers. For example, ectopic miR‐186 expression leads to enhanced cell proliferation and migration in pancreatic cancer. However, the role of miR‐186 in prostate cancer (PCa) remains unclear. Previously, we observed significant upregulation of miR‐186‐5p in PCa patient serum (stage III/IV) relative to non‐cancerous controls. Furthermore, miR‐186 was significantly up‐regulated in metastatic PCa (PC‐3) cells compared to normal prostate epithelial cells (RWPE1). We hypothesized miR‐186 inhibition will reduce aggressive PCa in vitro.