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[Mechanisms of toxico-kinetic interactions of metals in the body and their health-related significance].

From the point of view of modern bio-coordination chemistry the study of metal toxicokinetics showed that changes in metal metabolism within biological media under their combined body intake were closely related to their competition for biologic ligands. Formation of readily and hardly soluble metal complexes, governing their behavior in biologic media, depended not only on ion charge, range, and hydratation energy but also on rigidity and softness of interacting compounds. The constant of each element was also significant in metal competition for bio-ligand capture. It was proposed to use a complex of physical and chemical characteristics of metals in toxicokinetics prediction under their combined body intake.