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Contractile Effects of Tetradecapeptide Renin Substrate on Rat Femoral Resistance Vessels

The effect of products of the renin-angiotensin system on the contractile response of rat resistance vessels (internal diameter ˜200 μm) has been investigated. The vessels were isolated from the femoral bed and segments of the vessels were mounted on an isometric myograph. The vessels responded in a concentration-dependent manner to synthetic tetradecapeptide (TDP) renin substrate, angiotensin I (ANG I) and angiotensin II (ANG II), the responses to all these substances being inhibited by saralasin (0.1 μ mol/l). The responses to ANG I, but not those to TDP renin substrate, were inhibited by captopril (1 mmol/l). In contrast, the non-specific protease inhibitor aprotinin had an inhibitory effect on responses to TDP renin substrate. The results suggest that TDP renin substrate is converted to ANG II by a process that does not involve metabolism of ANG I.