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Design for the peptide analog of calcium binding loops by considering the steric restriction effect of incorporated nonprotein amino acids

A dodecapeptide was designed for a structural analog of calcium binding loops in EF-hand based on their averaged dihedral angles. The synthesized peptide contains three nonprotein amino acids, namely a D-alanine and two α-aminoisobutyric acids, which help this small segment to conserve the intrinsic conformation in calcium binding proteins by their steric restriction effect.