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Effect of ACTH-(4-10) on Bechterew's compensation in squirrel monkeys.

ACTH-(4-10), a fragment of the ACTH without hormonal action, has been known to have effects on learning and memory process. Recently, we have shown that ACTH-(4-10) had marked effects on the balance compensation process after unilateral labyrinthectomy in squirrel monkeys. In this study, we examined the effect of daily administration of ACTH-(4-10) following two-staged bilateral labyrinthectomy. When the locomotor balance function and the slow-phase eye velocity of the spontaneous nystagmus were analyzed, the ACTH-(4-10) groups compensated significantly faster than the control group (p less than 0.05).