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Effect of Obesity in the Rat on Renal Transport of Organic Acids and Bases 1

Summary The effect of obesity on accumulation of PAH by rat renal cortical slices was determined using an in vitro slice technique. Accumulation of PAH was significantly depressed in animals made obese by feeding a high-fat diet. Accumulation of PAH decreased with increasing age, body weight and kidney weight independent of diet. Organic base accumulation was determined to demonstrate the specificity of the effect of the high-fat diet and obesity on organic acid transport. Accumulation of the base NMN was not different in renal tissue from grain-fed and high-fat-fed animals. There was no correlation between NMN accumulation and body weight. In high-fat-fed animals NMN accumulation by renal cortical slices decreased with increased age and kidney weight. Age and kidney weight in the grain-fed animals was not related to NMN accumulation. The data suggest that obesity and/or the constituents of the high-fat diet have a depressant effect upon the kidney. Since NMN accumulation was not influenced it is concluded that the effect is not a generalized depression of renal function but selective depression of organic anion transport.