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Intercellular adhesion molecule‐1: a consistent inflammatory marker of the cutaneous radiation reaction both in vitro and in vivo

Background  Radiation damage to skin is a key diagnostic and prognostic parameter for patients accidentally exposed to radiation. Moreover, skin is a target organ for crucial side‐effects of routine radiotherapy. The pathophysiology of the cutaneous radiation reaction is in many respects still unknown. The acute inflammatory radiation reaction of skin has been shown to involve alterations in cell–cell and cell–matrix interactions, which are mediated by cellular adhesion molecules.