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Unraveling the Mystery of Peroxiredoxin IV Secretion Reveals a Redox‐independent Unconventional Protein Secretory Pathway

The peroxiredoxin (Prx) family of proteins functions as leading cellular antioxidants that scavenge hydrogen peroxide as well as contributes to oxidative signaling under both physiological and pathological conditions. As the only member containing a putative signal peptide, Prx4 has been long suspected to be secreted extracellularly to fulfill the role of maintaining local and systemic redox homeostasis. However, the absence of experimental evidence on Prx4 secretion and the lack of mechanistic input compromise the understanding of its role and significance in the pathogenesis of human diseases. The purpose of this study is to unravel the mystery of Prx4 secretion and to determine its secretory mechanism in human normal cells under physiological conditions.