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Distribution of Radioactivity in Rats Injected Intravenously with 125I‐Labeled Histamine‐Sensitizing Factor of Bordetella pertussis

Histamine-sensitizing factor (HSF) of Bordetella pertussis, a protein toxin also referred to as lymphocytosis-promoting factor, islet-activating protein (IAP), per tussigenand pertussis toxin, induces a variety of physiologic and pharmacologic effects in animals (8, 10-12). We have shown that HSF also induces in rats an increased release of glycerol in adipocytes (3, 5), an altered pharmacologic response of the atria by binding at a constant ratio (2, 3), and, in nonsensitized rats, a pleu rorrhea(1). These findings suggest that HSF could bind a variety of cells or tissues to induce various reactions. However, whether there exists any specific target organ or tissue for HSF has not been clear. In this study an attempt was made to find the target organ or tissue in rats, by binding assay with radioisotope-labeled