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Pituitary Stalk Interruption Syndrome in a Newborn with Encephalopathy: A
Case Report



Pituitary Stalk Interruption Syndrome is a rare midline brain anomaly involving the pituitary gland that leads to a variable degree of pituitary
hypofunction with a classic neuroimaging finding of the ectopic posterior pituitary, thin or absent pituitary stalk, and anterior pituitary hypoplasia.



We present the case of a term newborn who developed encephalopathy and respiratory distress during the neonatal period and was later diagnosed
with Pituitary Stalk Interruption Syndrome.



Genetic defects have been identified in 5% of cases, and at times there are associated extra pituitary malformations. In spite of being a welldescribed syndrome, a detailed description of its neonatal presentation and course is lacking in the literature.
