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IMPORTANCE OF BLOOD‐GROUP SUBSTANCES IN INTERACTIONS BETWEEN MAN AND MICROBES *

The term blood-group substances for the ABH(0) antigens is justifiable only on the basis of historical development, i.e., the discovery of these substances on the surface of human erythrocytes.' Their isolation from epithelial fluids shows the restrictive nature of this term. Substances possessing the same, or closely similar, activity are found from microbes and higher plants to man.29 They are ubiquitous structures possessing receptor properties that, in addition to their function as receptors of antibodies, may have other physiologically more important tasks.4 These surface structures are receptors in the sense defined by Paul Ehrlich: and play a profound role in a multitude of interactions between microbes of many kinds and man.