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Bladder specific genes and transcription factors

Scanty is the information about individual detrusor and urothelium transcriptomes. Here we have defined bladder tissue‐ and disease‐specific genes and transcription regulatory elements (TRE). Using a mouse model of LPS‐induced cystitis, we generated 6 different subtractive suppression hybridizations (SSH) between control and inflamed bladders. Next, SSH‐selected transcripts along with their upstream transcription factors were assembled in regulatory networks. The control bladder mucosa presented TREs driving genes such as myosin light chain phosphatase and calponin 1 that influence the smooth muscle phenotype. In the control detrusor network, Pax‐3 was significantly over‐represented. During development, the Pax‐3 maintains progenitor cells in an undifferentiated state whereas, during inflammation, Pax‐3 was suppressed and genes involved in neuronal development (synapsin I) were up‐regulated. Therefore, during inflammation, an increased maturation of neural progenitor cells in the muscle may underlie detrusor instability. In contrast, the inflamed mucosa regulatory network presented over‐expression of NF‐kB.