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Nanoparticles: A Prussian Blue-Based Core-Shell Hollow-Structured Mesoporous Nanoparticle as a Smart Theranostic Agent with Ultrahigh pH-Responsive Longitudinal Relaxivity (Adv. Mater. 41/2015).

A novel core-shell hollow-structured HMPB-Mn (HMPBs = hollow mesoporous Prussian blue nanoparticles) as an intelligent theranostic nanoagent, is successfully constructed by H. Chen, J. Shi, and co-workers as described on page 6382. This is achieved by coating a similarly crystal-structured Mn-containing Prussian blue analogue onto hollow-structured mesoporous Prussian blue nanoparticles. These can be used as pH-responsive T1 -weighted magnetic resonance imaging (MRI) contrast agents (CAs) with ultrahigh longitudinal relaxivity, and achieve the real-time monitoring of drug release.