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Tooth transformer®: A new method to prepare autologous tooth grafts – Histologic and histomorphometric analyses of 11 consecutive clinical cases

Introduction: Human dentin matrix could be successfully used for bone grafting procedures. It was well accepted that dentin grafts can induce osteoblast proliferation. An innovative preparation method, using the dedicated automated device Tooth Transformer®, which can transform autologous teeth in suitable grafting material, has been recently introduced. The aim of the present article is to analyze the histologic outcomes in 11 consecutive human cases, in which autologous tooth graft materials, starting from the whole tooth of the patient, were used for bone regeneration. Results: The bone defects were completely filled by newly formed tissue after 4 months of healing. Histologic analysis revealed no inflammatory or infective reactions against the tooth graft. Tooth granules were surrounded by newly formed bone. Some tooth granules were incorporated in the bony trabeculae, and they appeared partially resorbed. This fact testified that tooth grafts underwent remodeling processes just like the native bone. Discussion: Results from the present histologic case series analysis revealed that tooth graft appeared well integrated in the regenerative tissue without any inflammatory or infective reaction. The tooth of the patient may be used as an autologous regenerative material, avoiding any foreign graft material.