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[PP.18.07] RELATIONSHIP OF ELASTIC VASCULAR WALL PROPERTIES, RENAL FUNCTION AND INFLAMMATORY BIOCHEMICAL MARKERS IN HYPERTENSIVE PATIENTS WITH METABOLIC DISORDERS

Objective: To study the elastic properties of vascular wall, 24-hour blood pressure (BP) profile, parameters of renal function, biochemical parameters and their relationship with metabolic disorders in patients with arterial hypertension (AH) and metabolic disorders (abdominal obesity and dyslipidemia). Design and method: 130 patients (mean age 47.20 ± 9.6 years) were divided into 2 groups. The main group (group 1) included 77 subjects with AH degree I-III and MD (mass body index (MBI) 34.5 ± 3.9 kg/m2) and the control group (group 2) contained 53 subjects with AH without MD. The parameters of 24-hour BP monitoring, sphygmography, renal function (microalbuminuria, creatinine and estimation glomerular filtration rate (eGFR) using MDRD formule), parameters of the lipid profile, inflammatory markers – homocysteine, C-reactive protein (hs-CRP) and fibrinogen were estimated. Results: In group 1 there was registered significant increase in mean 24-hour and daytime systolic BP (SBP), time and square indices, in night time SBP and diastolic BP variability (p < 0.001); in sphygmography indices (cardio-ankle vascular index (CAVI), pulse wave velocity (PVW) and anklebrachial index (ABI) (p < 0.01); in parameters of renal function - microalbuminuria and eGFR (p < 0.001); in biochemical parameters - total cholesterol, fibrinogen (p < 0.016) and hs-CRP level (p = 0.04) compared to group 2. In group 1 correlation analysis revealed a positive correlation between microalbuminuria and PWV-R (p = 0.039), creatinine and R-ABI (p = 0.007), eGFR and L-ABI (p = 0.05), hs-CRP and CAVI and between fibrinogen and eGFR (p < 0.05). Besides, regression analysis method in patients with AH degree I revealed a positive relationship of creatinine with PWV-L (R2 = 0.14, p = 0.03), in patients with AH degree II - creatinine with CAVI and MBI (R2 = 0.451, p = 0.004 and p = 0.012). Conclusions: The relationship between elastic parameters of vascular wall, inflammatory markers, parameters of renal function and MBI has a pathogenetic basis for the progression of hypertension and impaired function of the target organ.