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Reflectance confocal microscopy for monitoring the density of Demodex mites in patients with rosacea before and after treatment

Demodex mites seem to serve as a pathogenic trigger in many Demodex‐associated diseases such as rosacea. In facial skin of patients with rosacea significantly higher numbers of Demodex mites have been shown compared with healthy controls. Reflectance confocal microscopy (RCM) allows the detection and quantification of Demodex mites in vivo noninvasively. It is hypothesized that a reduction of Demodex mites under rosacea therapy can be monitored by RCM.