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COMPARISON OF EFFICACY OF ATRACURIUM AND CISATRACURIUM IN
PATIENTS UNDERGOING ABDOMINAL SURGERIES UNDER GENERAL
ANESTHESIA AT DMCH, LAHERIASARAI, BIHAR

Background: The present study was done to test compare the efcacy of atracurium and cisatracurium regarding onset time, intubating conditions,
hemodynamic effects, duration of action, signs histamine release and evaluate whether cisatracurium is more effective than atracurium with regard
to the criteria.
Materials And Methods: This study was done in the Department of Anaesthesia, Darbhanga Medical College and Hospital, Laheriasarai, Bihar.
Study was done for a period from July 2019 to November 2020. An informed consent was taken from all patients. Group A (25 patients) received
Atracurium 0.5mg/kg IV and Group B (25 patients) received Cisatracurium 0.3mg/kg IV.
Results: Duration of action of Cisatracurium (0.3 mg/kg) is signicantly high compared to Atracurium (0.5mg/kg) with p<0.001. 83% of patients
treated with Cisatracurium had excellent intubating conditions as compared to 47% with Atracurium which was signicant. Hemodynamic
changes in either of them were clinically insignicant. Signs of histamine release was seen in two patients in Atracurium group whereas none in
Cisatracurium group.
Conclusion: Cisatracurium at a higher dose of 0.3mg/kg as compared to Atracurium 0.5mg/kg provided more effective and rapid neuromuscular
blockade with excellent intubating conditions, longer duration of action, stable hemodynamics and no associated signs of histamine release
clinically.