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Scheiblhofer S, et al. Pediatr Allergy Immunol. 2018;29:679–688. https://doi.org/10.1111/pai.12964 Allergen‐specific immunotherapy requires a long course of treatment and is not without adverse effects. Plasmid DNA or mRNA vaccines encoding allergens have been proposed as form of allergy prevention by helping induce T helper 1 and T‐regulatory responses. In this review, the authors examine the evidence to date regarding DNA and mRNA vaccines in allergy prevention, particularly regarding its potential benefits and adverse effects.