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Utilization of green analytical chemistry principles for the simultaneous estimation of paracetamol, aceclofenac and thiocolchicoside by UV spectrophotometry

ABSTRACT The present paper describes multicomponent UV spectrophotometric method for the determination of paracetamol, aceclofenac, and thiocolchicoside based on the fundamentals of green analytical chemistry. Major pharmaceutical companies and research laboratories encompass on green analytical methodologies for developing environmental friendly analytical methods. The present work is based on the principle of simultaneous equation involving additive of absorbances at the selected wavelengths. The linear range was established between 5–15 µg/mL for paracetamol, 1–5 µg/mL for aceclofenac, and 1–5 µg/mL thiocolchicoside. The greenness profile of the developed UV spectrophotometric technique was evaluated using National Environmental Methods Index, Analytical Eco-scale and AGREE metrics which proved the greenness of the method with respect to solvent, chemicals, energy consumed, and waste produced. The proposed method being simple, economical, and eco-friendly could be convenient substitutes for the use of hazardous chemicals in the routine investigation of the selected triple drug combination. GRAPHICAL ABSTRACT