{'fraction_non_alphanumeric': 0.029893924783027964, 'fraction_numerical': 0.0019286403085824494, 'mean_word_length': 5.368098159509202, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Magnetic/pH-sensitive nanocomposite hydrogel based on radiation prepared 2-(N, N′-dimethylamino) ethyl methacrylate/chitosan for in vitro drug delivery application

Abstract This study aimed to manufacture a new pH-responsive hydrogel based on 2-(N, N′-dimethylamino ethyl methacrylate) DMAEMA and chitosan CS by the impact of gamma radiation which introduces high sensitivity to the variation in the pH of the medium depending on the composition of DMAEMA/CS. The highest swellable DMAEMA/CS composition was used as a precursor for the preparation of a magnetic counterpart with more valued properties as increased surface area and reactivity. The various pH-responsive hydrogels DMAEMA/Cs and magnetic hydrogel DMAEMA/CS/M have been studied and examined intensively as a controlled drug delivery system and smart drug carriers specific for stomach treatment. Kinetics of Pantoprazole drug release (as model drug) from DMAEMA/CS hydrogels and the DMAEMA/CS/M magnetic nanocomposite are illustrated in this manuscript. Graphical abstract