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Mental Health Consequences of Lockdown During the COVID-19 Pandemic: A Cross-Sectional Study

Objective We aimed to provide an overview of the psychological status and behavioral consequences of the lockdown during the COVID-19 pandemic in Libya. Methods A cross-sectional study was conducted among the Libyan population through May and June 2020 in more than 20 cities. The survey comprised basic demographic data of the participants and anxiety symptoms measured using the seven-item Generalized Anxiety Disorder scale (GAD-7) with ≥15 as the cut-off score for clinically significant anxiety symptoms. Additionally, a survey regarding the lockdown effect was administered, which consisted of several parts, to measure the lockdown status. Results A total of 8084 responses were recorded, of which, 5090 (63%) were women and 2994 (37%) were men. The mean age (SD) for study participants was 27.2 (8.9) years. Among the participants, 1145 (14.2%) reached the cut-off score to detect anxiety symptoms; however, of the study variables, only five were predictors of clinically significant anxiety: age, gender, marital status, work status, being a financial supporter for the family, and being infected with COVID-19. Women had 1.19 times higher odds to exhibit anxiety symptoms than men. Increasing age was significantly associated with reduced likelihood of exhibiting anxiety symptoms, whereas being married was significantly associated with higher likelihood of anxiety symptoms, compared to not being married. Being suspended from work was associated with an increase in the likelihood of anxiety symptoms. However, we found that being infected with COVID-19 was associated with a 9.59 times higher risk of exhibiting severe anxiety symptoms. Among the study participants, 1451 (17.9%) reported a physical and/or verbal abuse episode from family members, 958 (11.9%) reported abuse outside the family, and 641 (7.9%) reported abuse from enforcers, during the lockdown. Conclusion Our study provided an overview of the psychological and behavioral status, among those who resided in Libya during the civil war and COVID-19 pandemic. The study demonstrates a concerningly high level of clinically significant anxiety during lockdown among the Libyan population during Libya’s lockdown period.


INTRODUCTION
Severe acute respiratory syndrome coronavirus-2 was identified as the cause of coronavirus disease 2019 . Since then, this infectious disease has caused unprecedented challenges for healthcare systems around the world, resulting in a pandemic that has resulted in greater than 96.2 million cases of COVID-19 and greater than 2.06 million deaths worldwide, as of January 21, 2021 .
The COVID-19 pandemic has affected the population and societies around the world, raising anxiety, stress, and an increased financial burden effect of unemployment and resulting in people losing their jobs, which has had negative consequences on families and individuals' behaviors and perceptions of life (Taylor, 2019;Gualano et al., 2020;Ni et al., 2020).
As the pandemic has spread worldwide, authorities and societies have imposed administrative restrictive measures and lockdown procedures to prevent the spread of the viral infection (Alfano and Ercolano, 2020;Lau et al., 2020;Moris and Schizas, 2020). Libya has implemented several restrictive procedures to control virus spread since March 2020, including lockdown measures.
These measures can have a dramatic effect on the mental health of people. The lockdown adds to the effect endured by people who lost their job due to the pandemic, which results in higher pressure on families to generate adequate financial support. The isolation and lockdown measures have several negative mental health consequences, which are due to family separation, loss of personal freedom, and the stress related to socioeconomic consequences of the pandemic . During a global pandemic, people in special lockdown settings are in need of medications, food, and an ability to maintain a normal lifestyle, therefore these concerns should be addressed (Matias et al., 2020). Further, the sleep and weight changes that have occurred during the lockdown period should be addressed (Huang and Zhao, 2020;Sher, 2020).
A study conducted among 4872 participants in 31 provinces and regions in China found that 22.6% have anxiety symptoms, and 48.3% have depressive symptoms (Gao et al., 2020). Another study conducted among 3480 participants from Spain found that 21.6% displayed anxiety symptoms, and 18.7% have depressive symptoms (González-Sanguino et al., 2020). A similar study in Italy, found 18.7% have anxiety symptoms (Mazza et al., 2020). Another study conducted in Turkey among 343 participants in the young age group revealed high anxiety symptoms in 45.1% (Özdin and Bayrak Özdin, 2020). However, there was no recent study among the African general population, as most of the recently published studies were in other regions and continental areas other than Africa (Xiong et al., 2020). Therefore, there is a need to assess the consequences of COVID-19 lockdown on the African population's behavioral and mental status.
By January 15, 2021, greater than 107,000 COVID-19 cases and 1,645 COVID-19-related deaths were reported in Libya. The Libyan government initiated lockdown measures and restrictive policies in March 2020; therefore, after 2 months of lockdown, there was a crucial need to address the mental health status of the Libyan population and to assess the socioeconomic status of people during the lockdown. Herein, we aim to provide an overview of the psychological status and behavioral consequences of the lockdown during COVID-19 in Libya.

MATERIALS AND METHODS
An online cross-sectional survey was conducted using Google Forms among the Libyan population through May and June 2020 in more than 20 cities. The survey was conducted anonymously using email and social media without identified data. The survey comprised basic demographic data of the participants and anxiety symptoms, measured using the seven-item Generalized Anxiety Disorder scale (GAD-7) (Spitzer et al., 2006) with ≥15 as the cut-off score for anxiety symptoms. The GAD-7 cut-off score of 15 or more was calculated by Gillis et al. (1995). The GAD-7 demonstrated good internal consistency, as determined by a Cronbach's alpha level of 0.88 in a pilot study among the Libyan population. Additionally, a survey regarding the effect of lockdown was administered. The survey consisted of several parts, as follows: the first part involved the lockdown status, which measured the hours of lockdown, availability of services, number of working hours, and prevalence of abuse episodes; the second part involved lockdown activities, frequency of visitors, and shopping status before and during lockdown; the third part included internet activity and use during and before lockdown; the fourth part included sleep and weight change questions; and the fifth part included general health-related questions and the civil war effect on the Libyan population. The Libyan population numbered approximately 6,878,310 as of 30 July 2020 based on the Worldometer elaboration of the latest United Nations data (Worldometer, 2020). We estimated the required sample size based on a population size of 6,878,310 with a percentage estimated completion rate of 50% and a 95% confidence interval of 1.1 and a sample size of 7928 needed for the study.

Ethical Considerations
Ethical approval for this study was obtained from the Bioethics Committee at the Biotechnology Research Center in Libya. All participants provided written informed consent before participating in the study.

Statistical Analysis
Descriptive statistics were used to describe the data and survey responses using frequencies and percentages. A chi-square test was used to determine the association between anxiety symptoms and basic participant data characteristics. Mann-Whitney tests were used for continuous variables to compare differences. A Wilcoxon signed-rank test was used to determine the effect of lockdown on the number of people who visited the participants' homes in the past week, changes in internet use, sleep time, and the time spent awake by estimating the pre-and post-effect of lockdown on these variables based on self-reports (each question contain choices that were put into a four-point scale to be used for estimating differences from pre-to post-lockdown on these variables and to determine if there is a median difference between two conditions). Binomial logistic regression was performed to ascertain the effects of study variables on the likelihood that participants have clinically significant anxiety symptoms (GAD ≥ 15). Data entry and analysis were performed using SPSS (version 25.0; IBM Corp., Armonk, NY, United States).

RESULTS
A total of 8084 responses were collected through the online survey. Of the participants, 5090 (63%) were women and 2994 (37%) were men. The mean age (SD) for study participants was 27.2 (8.9) years. Due to the online structure, we were not able to estimate the response rate. Table 1 shows an overview of the basic study characteristics and the associations of the cutoff score of anxiety symptoms (GAD score ≥ 15) with a high likelihood of anxiety symptoms; those with GAD < 15 were less likely to exhibit anxiety symptoms. Among the participants, 1145 (14.2%) reached the cut-off score to detect clinically significant anxiety symptoms; however, only gender, age range, marital status, educational level, job status, working status during the COVID-19 pandemic, number of hours worked per week, and being personally infected with COVID-19 were statistically associated with anxiety symptoms (p < 0.05). On the other hand, being the financial supporter of the family and having a friend or family member infected with COVID-19 were not associated with anxiety symptoms (p > 0.05). A binomial logistic regression was performed to ascertain the effects of study variables on the likelihood of participants having clinically significant anxiety symptoms. The logistic regression model was statistically significant, χ 2 (22) = 165.67, p < 0.001. Of the study variables, only five were statistically significant predictors: age, gender, marital status, work status, being the financial supporter for the family, and being infected with COVID-19. Women had 1.19 times higher odds to exhibit anxiety symptoms than men. Increasing age was significantly associated with reduced likelihood of exhibiting anxiety symptoms, and being married was significantly associated with higher likelihood of anxiety symptoms, compared to not being married. Being suspended from work was associated with an increase in the likelihood of anxiety symptoms. However, we found that being infected with COVID-19 was associated with 9.59 times higher risk of exhibiting clinically significant anxiety symptoms. Table 2 illustrates an overview of the binominal logistic regression analysis.
Regarding the lockdown status, most participants (6122 [75.7%]) thought that the nationwide lockdown was a good idea. Greater than half of the participants (4692 [58%]) reported staying at home all day during the lockdown, and 7234 (89.5%) reported the availability of basic life needs. Just under half of the participants (3347 [41.4%]) reported that they shared a residence with four to six people. Only 4108 (50.8%) participants reported that children were involved in home-schooling. However, this represented most of the 57.5% of the respondents with children at home during the lockdown. Table 3 summarizes the participants' answers to the lockdown status survey. Among the study participants, 1451 (17.9%) reported a physical and/or verbal abuse episode from family members, 958 (11.9%) reported abuse outside the family, and 641 (7.9%) reported abuse from enforcers during the lockdown. We found an association of gender with abuse types: women encountered higher physical and/or verbal abuse from family members than men (10.6% vs. 7.3%, p < 0.001). The same higher rate of physical and/or verbal abuse from someone outside the family was found in women compared to men (7.9% vs. 3.9%, p = 0.009). However, physical and/or verbal aggression from enforcers implementing the lockdown was higher among men compared to women (4.4% vs. 3.5%, p < 0.001). A Wilcoxon signed-rank test was used to determine the effect of lockdown on life satisfaction; there was a statistically significant median decrease in life satisfaction from pre-lockdown (3.86) to post-lockdown (2.75; p ≤ 0.001). Of study participants, 3294 (40.7%) reported continuity of their salary, while 4790 (59.3%) reported a lack of income or salary during lockdown. Moreover, 5589 (69.1%) reported that their life was put on hold or their work stopped after the lockdown.
A Wilcoxon signed-rank test was used to determine the effect of lockdown on the number of visitors. There was a statistically significant median decrease in the number of visitors  . Only 2409 (29.8%) participants reported enrollment in online courses, whereas 4057 (50.2%) reported that they used the internet to spread information about the COVID-19 pandemic. We used a Wilcoxon signed-rank test to determine if there were differences in keeping in touch with others using the internet before and during lockdown, and found a statistically significant median increase in use of the internet for contacting people from pre-(3.57) to post-lockdown (3.82; p ≤ 0.001). Table 5 shows internet activity use among study participants.
We performed a Wilcoxon signed-rank test to determine if there were differences in the time of going to bed before and during the lockdown. There was a statistically significant median increase in the time going to bed being late from pre-lockdown (3.6) to post-lockdown (4.4), p < 0.001, which means that people tended to go to bed later at night during the lockdown, compared to pre-lockdown. Moreover, there was a statistically significant median increase in the time of waking up from pre-(3.6) to post-lockdown (4.7; p < 0.001), which means that participants woke up later during the lockdown period compared to prelockdown. Further, 4736 (58.6%) reported weight increase during lockdown. There was a statistically significant median decrease in performing physical exercise from pre-(1.83) to post-lockdown (1.65; p < 0.001), which means that people were engaging in less exercise during the lockdown period. Table 6 provides an overview of the sleep and weight changes. With respect to the general health status and civil war effect on the study population during the COVID-19 pandemic, we found that most of the participants (5726 [70.8%]) felt irritable, 5666 (70.1%) felt angry, 5178 (64.1%) reported difficulty in sleeping, and 5089 (64%) reported feeling sad. Table 7 provides an overview of the health and civil war status during the lockdown. Approximately one-half of the participants (2953 [36.5%]) reported obstacles to seeking medical care. Most participants reported that the civil war affected their quality of life to different degrees; specifically, 3782 (46.8%) experienced a devastating effect, 1120 (13.9%) had a significant effect, 1631 (20.2%) had a moderate effect, 497 (6.1%) minimum effect, and 1054 (13%) reported no effect. Approximately half of the participants (3480 [43%]) were targeted by attacks during the conflict, 2637 (32.6%) reported the death of a loved one or relative by the civil war, and 1812 (22.4%) were forced to relocate from their previous residence due to the civil war.

DISCUSSION
Our study focused on the Libyan population between May and June 2020, subsequent to the lockdown measures in March 2020. We measured the psychological and lockdown status of Libya during the COVID-19 pandemic.
Our study demonstrated several factors associated with anxiety symptoms, changes in behavior, lockdown activity status, internet activities, health status, civil war effects, and sleep and weight changes after commencing the lockdown. We demonstrated that 1145 (14.2%) of the study population reached the cut-off score to demonstrate clinically significant anxiety symptoms using the GAD-7 scale. Anxiety symptoms were statistically associated with gender, age, working status during the COVID-19 pandemic, being the family's financial supporter, and being personally infected with COVID-19.
A previous study that was conducted in China during the early weeks of the COVID-19 pandemic found a prevalence of anxiety of 22.6% by using a GAD-7 cut-off score of ≥10 for identifying cases of anxiety symptoms (Gao et al., 2020). However, our study used a GAD-7 cut-off score of ≥15. Cao et al. (2020) conducted a study among 2279 participants from China Two to three times a week 1008 (12.5) More than three times a week 767 (9.5) during the COVID-19 pandemic using GAD-7 found that severe anxiety (GAD-7 > 15) was found in 0.9%, and moderate anxiety (GAD-7 10-14) in 2.7% of the study participants, which is lower than our results. Approximately half of our participants (41.4%) reported that they shared residency with four to six other people, which raised concerns about the risk of spreading infection among the residents during lockdown. Another concern based on our findings was the rate of verbal and/or physical abuse, which is of concern because 17.9% of the participants experienced abuse from family members, 11.9% from someone outside their family, and 7.9% from law enforcers, during the lockdown. Women and children may have been at higher risk of domestic violence. According to UN Women (United-Nation, 2020; Vora et al., 2020), domestic violence increased substantially during 2020. Therefore, there is a need to implement regulations and policy to protect women and/or children who may be at risk of domestic violence. Our study was the first to demonstrate these rates in Libya, which can be explained by the financial instability due to the COVID-19 pandemic and the civil war effect. Indeed, the COVID-19 pandemic and civil war had catastrophic effects on the mental health status of the Libyan population (Vora et al., 2020). There was a significant decrease in the life satisfaction of the study participants from before to during the lockdown. This is a major concern due to the lockdown effect, financial stress, and socioeconomic instability, which may need further assessment and urgent intervention. These concerns that happened during lockdown should alarm and inform the authorities to take actions and efforts to mitigate the negative consequence of COVID-19 pandemic on life satisfaction and well-being of people (Zhang et al., 2020).
Only 40.7% of the participants continued to receive their monthly salary during the lockdown and our study demonstrated that greater than 20.5% of the study population were unemployed. These findings are of significant importance because more than 69.1% of the participants reported that their workplace experienced difficulties due to the COVID-19 pandemic. The global impact of the COVID-19 pandemic increased the loans required by people, which was a financial catastrophe for many workers and employees who lost their jobs (Nicola et al., 2020). UNESCO estimated that approximately 900 million learners have been affected due to the disruption in education due to COVID-19 (Viner et al., 2020). Therefore, there is a need for an emergency relief plan for the Libyan population who are suffering from the COVID-19 pandemic on top of the adverse impact of the civil war (Elhadi and Msherghi, 2020). The authorities need to implement specific steps to alleviate the results of the pandemic on the socioeconomic lives of the Libyan population by providing loans, supporting online educational learning, increasing safety measures in public buildings and institutes, and providing major steps to facilitate the basic life supplies for people who are in need during difficult times.
Variety of activities were reported during the lockdown: most participants reported internet surfing (95.9%) and watching TV (74.1%). We also observed a significant decrease in terms of visits to meet others per week, before and after the lockdown. This means that people are likely to adhere to the social distancing rules; however, there were still some participants reporting visits by others two to three times per week (13.6%) and nearly every day (4.8%). Additionally, we observed a significant decrease in shopping times per week compared with the pre-lockdown period, although there were still some participants reporting shopping everyday (6.3%) and two to three times per week (10.1%). Therefore, there is a need to implement more guidance for people to prevent the risk of transmission. There is also a need to implement online shopping because of the lack in Libya, which can reduce this burden and let the stores deliver the daily needs of people at home to reduce the risk of gathering and therefore reduce the risk of transmission (Sheth, 2020).
We observed a significant increase in internet use during the lockdown by comparing it to the previous period before the lockdown; however, this increase in internet use can have negative consequences, because there is a concern of an increased risk of gambling, video gaming, and watching inappropriate content, which may have negative effects on society, as they are being used to reduce the stress-related effects of the lockdown. Therefore, there is a need for further discussion and measuring the prevalence and effects of these behaviors among people in the lockdown (Király et al., 2020). Moreover, another observation in our study was that 50.2% of the participants reported using the internet to spread information related to the COVID-19 pandemic, which can question the reliability of the information and whether false or misleading health-related information is being spread (Cuan-Baltazar et al., 2020).
We observed sleep changes during the COVID-19 lockdown. Specifically, people reported going to bed later during the lockdown compared to the previous period. We also observed a significant increase in the wake-up hours compared to the period prior to the lockdown. Therefore, there is a high likelihood of insomnia and sleep disturbances that need to be addressed in future, as insomnia and sleep disturbances have been reported during the COVID-19 pandemic (Morin and Carrier, 2020).
Among the study participants, 58.6% reported an increase in body weight. Additionally, we found a significant decrease in physical exercise by comparing the frequency of exercise before and during the lockdown. Both, an increase in weight and a reduction in physical exercise, were reported by the study participants. These behavioral changes carry a higher risk of obesity and metabolic syndrome and increase the risk of severe COVID-19 infection (Sanchis-Gomar et al., 2020).
Most participants also felt irritable (70.8%), angry (70.1%), and fatigued (61.5%). These behavioral changes are of major importance; the increase in risk of psychological stress-related issues, and the increase in prevalence of depression, anxiety, and post-traumatic stress disorders among study participants need to be addressed. Moreover, we found that one-third of the participants had difficulty in accessing healthcare services, which may increase the risk of chronic disease deterioration (Liu et al., 2020).
Most participants reported that the civil war affected their quality of life. The civil war had great psychological and socioeconomic effects on the quality of life of people and increased their stress due to fear and uncertainty. In addition, 43% of the participants were targeted by the conflict, 32.6% reported that they suffered a death of a loved one, and 22.4% were internally displaced due to the civil war. These negative effects had catastrophic consequences on the Libyan population and there is a need for longitudinal studies that provide more detailed information about the current status of the Libyan population during the civil war. Further, there is a need for actions to alleviate the difficulties and challenges endured by the Libyan people and to find socioeconomic and psychological intervention solutions to provide relief for the Libyan population.

Strength and Limitations
This study demonstrated a high level of stress among Libyans during the COVID-19 pandemic lockdown, with some more susceptible than others to experiencing clinically significant anxiety during the lockdown. The study was conducted using a large sample of 8084 participants with wide demographic and socioeconomic variations. There was a significant decrease in life satisfaction from pre-to during-lockdown and several important behavioral and psychological changes during the lockdown were observed.
Our study was a cross-sectional study, which may not have the ability to draw strong conclusions regarding causation. Another limitation that needs to be acknowledged is that the cross-sectional nature of the survey meant that changes from pre-to during-lockdown in the outcomes had to be assessed retrospectively, and participants may have recall bias, which may have affected the accuracy of their retrospective memory to these questions. Thus, future longitudinal studies to support or dispute our results are warranted, especially in the elderly population, who are known to have a higher risk of depressive and anxiety symptoms, compared to the younger population. Another limitation was that the study used an online survey, and thus, data for people without an internet connection during the study period was not collected. Additionally, the civil war effect was not addressed in detail and further studies are needed to address the posttraumatic stress disorder and depressive symptoms to measure the prevalence of possible stressful negative consequences of the civil war in further detail. Further, because we introduced a new tool for measuring the lockdown status, there is a need for further studies to validate the psychometric properties of our tool and to use it in different settings with different countries.

CONCLUSION
Our study provided an overview of the psychological and behavioral status among those who resided in Libya during the civil war and COVID-19 pandemic. The study demonstrates a concerningly high level of clinically significant anxiety during lockdown among the Libyan population during Libya's lockdown period. There is a need to address and solve the negative consequences of the lockdown to prevent further deterioration of the Libyan people's mental and socioeconomic status.

DATA AVAILABILITY STATEMENT
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

ETHICS STATEMENT
The studies involving human participants were reviewed and approved by the Biotechnology Research Center in Libya. The patients/participants provided their written informed consent to participate in this study.

AUTHOR CONTRIBUTIONS
AhA, AlA, and ME conceptualized the idea. AM and ME analyzed the data, revised the manuscript in response to reviewer comments and revised the manuscript for language and clarity and grammar. AM revised the statistics with ME and helped in preparing the results and tables. ME wrote the initial draft of the manuscript. Each author contributed to data collections, participated in revising the manuscript, and all agreed to accept equal responsibility for this manuscript's accuracy. All authors approved the final manuscript.

FUNDING
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.