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Study of the Lipophilicity of Novel Diquinothiazines

The lipophilicity of twenty new diquinothiazines has been determined by reversed-phase thin-layer chromatography on RP-18 silica plates with acetone-aqueous TRIS (tris(hydroxymethyl) aminomethane) buffer as mobile phase. The RM0 values were linearly dependent on the concentration of acetone. The RM0 values were determined by linear extrapolation to 0% acetone. The experimental lipophilicity log PTLC was determined by use of a calibration plot obtained for six standards. The calculated lipophilicity log Pcaled was obtained by use of the software ClogP and compared with experimental log PTLC values. Structure—lipophilicity relationships are discussed on the basis of the log PTLC values and the correlation between RM0 (intercept) and b (slope) of the TLC equation.