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HYPERTENSION IN RENAL TRANSPLANT RECIPIENTS: PP.30.216

Objective: Hypertension is a risk factor for both cardiovascular and renal disease. Hyperuricaemia is common following renal transplantation, and has recently been implicated in the pathogenesis of hypertension. The aim of this study was to review hypertension control and the role of hyperuricaemia in our patient cohort. Design and Method: We conducted a retrospective review of stable renal transplant recipients between January 1st 2009 and June 30th 2009 and recorded blood pressure and urate levels. Results: 69 patients were included with mean systolic blood pressure of 143.12mmHg (Standard deviation = 13.18) and diastolic blood pressure of 84.84mmHg (Standard deviation = 7.85). 88.4% (n = 61) were taking antihypertensive medications, 26.1% (n = 18) on diuretics and 30.4% (n = 21) had an elevated urate level. 13.0% (n = 9) were on allopurinol, 5 of whom an elevated urate despite treatment. Male patients on average had a higher urate level than females (p = 0.005). There was no association between allopurinol use and systolic or diastolic blood pressure. Elevated systolic and diastolic blood pressure readings were more common in those taking antihypertensives (p = 0.027 and p = 0.041 respectively). Systolic and diastolic blood pressure appeared higher in those patients with higher plasma urate levels, but did not reach statistical significance (see Table). Conclusion: The average blood pressure for our study population was above the recommended target for renal transplant recipients (<130/80mmHg). There was a trend towards higher blood pressure in those with an elevated urate level, including those taking allopurinol. We have identified the need to improve blood pressure control and a potential role for hyperuricaemia in the pathogenesis of hypertension amongst our renal transplant recipients. Figure 1. No caption available.