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Adoptive immunotherapy with donor lymphocyte infusionsafter allogeneic HPC transplantation

due to the loss of the graft-versus-leukemia (GVL) effect thathas been recognized as an important component of theanti-leukemic efficacy of allogeneic HPC transplantation,particularly for chronic myelogenous leukemia (CML). Thedemonstration of this GVL effect and of the primordial roleof T-lymphocytes led investigators to transfuse donor lym-phocytes to CML patients relapsing after HPC transplanta-tion.