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Adrenoceptor Blockers and Focal Ventricular Tachycardia during Coronary Artery Occlusion

Ventricular tachycardia (VT) of focal endocardial and Purkinje origin occurs in humans. Pharmacological blockade of adrenoceptors on endocardial tissues may selectively prevent the induction of focal VT. We tested the hypothesis that alpha adrenoceptor blocker WB4101(WB), beta‐1 receptor blocker Metoprolol (Met) and beta‐2 receptor blocker ICI 118,511(ICI) prevent the induction of focal ischemic VT and evaluated possible mechanisms.