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Study on Kinetics and Biocompatibility Evaluation of Multiple Polymer Layer with Biochemical Material Properties in Drug-Eluting Stent

The Paclitaxel-eluting stents (PTX) with three-layered polymer coating were studied in this work. The PLGA (polylactic acid-co-glycolic acid) with 15 percent PEG (poly ethylene glycol) concentration in blend have been applied for preparing multiple layer drug carrier and fabricated on the surface of 316L stainless steel stents by ultrasonic atomization spraying method. The Paclitaxel was explored in doses: (~255μg) for single layer coated PTX (30 wt%), and (~275μg) for multiple layer coated PTX in accordance. Pre- and post-expansion surface morphologies of multiple layer stent were examined by scanning electron microscopy (SEM). The Paclitaxel release kinetics was studied by comparative method of release profiles of single layer PTX with 3-layered polymer coated PTX. The biocompatibility by hemolysis ratio and dynamic clotting time with platelet adhesion measurements also was investigated.