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Searching for signals: mortality and cardiovascular events in published randomized control trials of nifedipine in ischemic heart disease and hypertension

Meta-analysis A meta-analysis of published randomized control trials of nifedipine in hypertension and stable angina pectoris was performed. Results The results suggest a formulation-dependent increased risk of mortality and adverse cardiovascular outcomes for monotherapy use in patients with stable angina pectoris. No increased risk was seen in the hypertension studies.