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Tau spreads across connected brain regions in progressive supranuclear palsy and corticobasal syndrome

Cortico‐basal degeneration (CBD) and progressive supranuclear palsy (PSP) are 4R‐tauopathies characterized by progressive tau pathology spread that typically starts in the subcortex. Pre‐clinical studies suggest that tau spreads across connected neurons in an activity‐dependent manner, indicating that the brains’ connectome may mediate tau spreading. Supporting this, we found in Alzheimer’s disease that PET‐assessed cortical tau spreads across functionally connected regions. Here, we assessed whether connectivity mediates cortical/subcortical tau spreading also in 4R‐tauopathies, by combining resting‐state fMRI connectivity with i) 2nd generation in vivo tau‐PET (PI2620) in CBS and PSP and ii) post‐mortem tau assessments in PSP.