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Regression of coronary atherosclerosis.

The study of therapeutic interventions to bring about the regression of atherosclerosis has been a major part of atherosclerosis research. Until recently, however, this objective had been realized only in experimental animal models. In the early part of this century, Anitschkow1 first demonstrated in a rabbit model of diet-induced atherosclerosis that atheromatous lesions would regress on withdrawal of the cholesterol-rich diet. Since that seminal observation, many studies have confirmed these results in other vertebrates, including birds, swine, dogs, and nonhuman primates. Several important observations have been made in these studies: that the ability to induce regression depends on the animal . . .