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Relationship Between Connexins and Atrial Activation During Human Atrial Fibrillation

Introduction: Gap junctional connexin proteins (connexin40 [Cx40], connexin43 [Cx43]) are a determinant of myocardial conduction and are implicated in the development of atrial fibrillation (AF). We hypothesized that atrial activation pattern during AF is related to connexin expression and that this relationship is altered by AF‐induced remodeling in the fibrillating atria of chronic AF.