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BRAF V600E mutation and the tumour suppressor IGFBP7 in atypical genital naevi

Background  Atypical genital naevi (AGN) are naevi of special sites with atypical histological features that overlap with those of malignant melanoma. Activating BRAF mutations, identified in the majority of banal melanocytic naevi and cutaneous melanomas, are reportedly uncommon in naevomelanocytic proliferations in nonsun‐exposed sites. We have recently shown that constitutive activation of the BRAF‐MEK‐ERK signalling pathway in oncogenic BRAF‐positive naevi increases expression and secretion of IGFBP7, which induces senescence and apoptosis.