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Functional and structural regulation of urate handling by human SLC2A9 isoforms in the Xenopus laevis oocyte expression system

Human GLUT9 (SLC2A9) is a high capacity urate transporter, backed by genome‐wide association scans. This gene's SNPs coincide with urate pathology1. The protein is predominant in liver and kidney, main organs in human urate homeostasis. Two splice variants of the carrier, SLC2A9a (A) and SLC2A9b (B), which differ in their residue composition in the N‐terminus, target differently to cell membranes of polarized epithelium2. Hydrophobic residues in this family of transporters were shown to play a role in hexose selectivity3.