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Anti‐inflammatory action of Cudrania tricuspidata on spleen cell and T lymphocyte proliferation

This study examined whether an extract of Cudrania tricuspidata shows anti‐proliferative effects in anti‐CD3/CD28‐mediated spleen and CD4+CD25− T cells and decreases the production of the pro‐inflammatory cytokines interleukin‐2 (IL‐2) and interferon‐γ (IFN‐γ) in anti‐CD3/CD28‐mediated CD4+CD25− T cells. The proliferation of anti‐CD3/CD28‐mediated spleen cells and CD4+CD25− T cells was effectively suppressed by C. tricuspidata. This extract, however, did not show cytotoxicity in spleen cells under conditions where the antigen was not stimulated using CCK‐8 analysis. C. tricuspidata also decreased the production of the pro‐inflammatory cytokines IL‐2 and IFN‐γ by selective inhibition of this extract on proliferating cells in anti‐CD3/CD28‐mediated CD4+CD25− T cells. These results suggest that C. tricuspidata may be useful in the treatment of autoimmune diseases and organ transplantation through the inhibitory action of T cells in inflammation.