{'fraction_non_alphanumeric': 0.03399668325041459, 'fraction_numerical': 0.00912106135986733, 'mean_word_length': 5.420212765957447, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Presynaptic Membrane Receptor‐Reactive T Lymphocytes in Myasthenia Gravis

The majority of patients with myasthenia gravis were shown to have T and Bcells specific for a β‐bungarotoxin binding protein, presynaptic membranereceptor (PsmR). Such autoreactive T cells may be subdivided into differentsubsets according to the pattern of cytokine production. In this study theauthors examined the subpopulation of the T cells by analysing their IFN‐γand/or IL‐4 secretion pattern. T cell response to human muscle acetylcholinereceptor (AChR) was examined in parallel. PsmR‐stimulated IFN‐γ secretionwas found in 60%, and IL‐4 secretion in 48% of the patients. Cells stimulated tosecrete both IFN‐γ and IL‐4 or IFN‐γ only were the most common patterns.Treatment of the cells with a mouse anti‐human HLA‐DR antibody abolished thesecretion of cytokines. There was a positive correlation between the numbers ofPsmR‐reactive and AChR‐reactive T cells. In conclusion, the results show thatPsmR‐stimulated T cells secreted IFN‐γ and/or IL‐4. This T cell response isMHC class II restricted. Thus, this study indicates that both Th1/Th2 or Th0subsets of the T cells are involved in the autoimmune response in thedisease.