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The Association of Detrusor Overactivity with Overactive Bladder Syndrome

Study design, materials and methods Records of women attending the urogynecology unit of a University Hospital with complaints of lower urinary tract and/or vaginal bulge symptoms who had a regular follow up between 2010 and 2013 were retrospectively reviewed (n=529). In order to identify women with OAB syndrome according to the definition of ICS as objective as possible, women who completely fulfilled both the Overactive Bladder Awareness Tool (OAB-V8) and the 3 day voiding diaries were selected (n=215). Women with a score >7 on the OAB-V8 and frequency >7/day were included (n=110). Women with urinary tract infection, neurological disease, uncontrolled diabetes/metabolic disease, patients with missing data and who refused the urodynamic examination were excluded. The final study population (n=49) was grouped according to the presence or absence of detrusor overactivity (DO) (Group 1; OAB with DO, n=32 and group 2; OAB without DO, n=17). Data for baseline characteristics, clinical examination and voiding diary findings, validated questionnaires for lower urinary tract symptoms, quality of life and sexual dysfunction (UDI-6, IIQ-7, OAB-V8, PISQ-12) and ambulatory urodynamic study findings (Duration, maximum cystometric capacity, post void residual volume (PVR), urge incontinence, urodynamic stress incontinence, urgency, obstructive voiding pattern) were compared. Pelvic organ prolapse (POP) staging was performed using the POP quantification system. Ambulatory urodynamic evaluation was performed using the LUNA ambulatory monitoring recorder (MMS). Measurement was started after the patients’ spontaneous micturition and the duration of monitoring was limited to each patient’s own micturition cycle, which was finalised when the patient felt unable to delay voiding. Statistical analysis was performed using the software SPSS (version 15, Chicago, IL, USA). The Student’s t test, Mann–Whitney U test and chi-square tests were used as appropriate. P values < 0.05 were considered significant.