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Towards the use of Proxy Reported Outcomes in MS

Methodological issues like incomplete data in MS studies and the potentially reduced reliability of longitudinal patient reports can partially be solved by using proxy respondents. In this thesis the agreement and disagreement between MS patients and proxy respondents are outlined and a comprehensive insight in the underlying factors of disagreement is given. For the use of proxy reports a model is developed to estimate patients' long term outcomes using proxy scores. Results described in this thesis can be considered as a step towards the use of proxy reported outcomes in MS research and clinical trials.