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Human Cytotrophoblastic Cells Absorb the NK Blocking Activity of Monoclonal BA11

PROBLEM: R80K is a polymorphic alloantigeneic protein present on human placental trophoblast and on paternal B lymphocytes and monocytes. This protein, unlike the former candidate TLX antigen, stimulates a protective maternal immune response in vivo. A murine monoclonal BA11 antibody, directed against R80K, prevents abortion in three murine pregnancy‐failure models and inhibits human and murine NK activity. We attempted to define the target of BA11 in the human NK assay system.