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Neutrophil antibodies are clinically important

Neutrophils or polymorphonuclear neutrophils (PMNs) make up the largest proportion (45 – 70%) of circulating leukocytes and play a pivotal role in innate immunity. Thus, patients with low PMN counts (neutropenia) or defective PMN function are more likely to be overwhelmed by infection. PMN reactive antibodies can cause either allo‐ or auto‐immune neutropenias. In some transfusion‐related acute lung injury (TRALI) events, donor derived neutrophil reactive antibodies can cause inappropriate activation of neutrophils leading to collateral damage of the surrounding pulmonary microvasculature with potentially grave clinical consequences.