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Captopril in Refractory Malignant Hypertension

The blood pressure of a 36-year-old male with malignant hypertension could not be controlled adequately by as many as eight concurrent oral and parenteral antihypertensive agents administered over a three-week period. These agents included the potent vasodilating agent minoxidil. Only after the initiation of captopril, an oral angiotensin converting enzyme inhibitor, was his blood pressure normalized.