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Inhibition of EZH2 attenuates coronary heart disease by interacting with microRNA‐22 to regulate the TXNIP/nuclear factor‐κB pathway

What is the central question of this study? The relevance of microRNA‐22 (miR‐22) has been indicated in coronary heart disease (CHD). How does it exert a protective role in CHD? What is the main finding and its importance? EZH2 inhibited transcription of the miR‐22 promoter, thus modulating cell proliferation in human umbilical vein endothelial cells and vascular smooth muscle cells to induce CHD.