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PERICARDIAL EFFUSION IN A PATIENT WITH HYPERTHYROIDISM: A CASE REPORT

Pericarditis and pericardial effusion are commonly associated with hypothyroidism. It is an uncommon association with hyperthyroidism. We present a case of pericarditis/pericardial effusion in a 28-year-old Nigerian lady with hyperthyroidism. There was resolution of the pericardial effusion with antithyroid medications and steroid therapy. We recommend a high index of suspicion of this association in patients with hyperthyroidism and/or Graves' disease.


INTRODUCTION
Herein, we present the case of a 28-year-old woman who was admitted with features of hyperthyroidism and pericardial effusion, the effusion resolved following treatment of hyperthyroidism.

CASE REPORT
A 28-year-old lady presented to the Medical Outpatient Clinic of our hospital on account of a three-months history of recurrent palpitations, easy fatigability and exertional dyspnea. Palpitations occur most times of the day but worse at rest. There was history diaphoresis but no chest pain or pressure like sensations on the    At presentation, she was restless, diaphoretic and mildly dehydrated. She was not febrile, not pale, anicteric, not cyanosed and had no digital clubbing. She had no significant peripheral lymphadenopathy and no pedal edema. There was an anterior neck swelling measuring 4 x 6cm but more to the right side. The swelling was firm in consistency with irregular edges, non-tender and no differential war mth. There was no exophthalmos or lid lag. There were fine tremors. She was dyspneic, respiratory rate was 36 breaths per minutes, trachea was central and breath sound were vesicular bilaterally. Her pulse was 112/min and regular, BP 120/70mmHg, JVP was not elevated and apex beat was difficult to localize. First and Second Hearts sounds were heard with pericardial friction rub. She was conscious, alert, oriented in time place and person, pupils 3mm equal, round, bilaterally reactive to light, no cranial nerve deficit, no sign of meningeal irritation, normal muscle bulk, tone and reflexes.
She was admitted for evaluation. Imaging studies revealed a relatively normal chest with a normal mediastinal contour. Table 1 shows the investigation results. The ECG (Figure 1) showed sinus tachycardia. Echocardiography ( Figure 2) revealed a pericardial effusion over the left ventricle with fibrinous strands in the pericardial cavity.
She was commenced on oral medications which includes prednisolone 40mg daily, propranolol 20mg b.d., rabeprazole 20mg daily and carbimazole 15mg b.d. She had made significant improvement on follow up clinic appointments.

DISCUSSION
Atrial fibrillation, thyrotoxic cardiomyopathy, pulmonary arterial hypertension, systemic hypertension and high or normal output heart failure are known cardiac complications of hyperthyroidism. The patient discussed had normal left ventricular function on echocardiography and ECG did not show any features of atrial fibrillation. An ongoing malignancy and infection especially tuberculous pericarditis was also considered but this was excluded by the absence of suggestive clinical picture and laboratory profile.
The possibility of pericardial effusion/pericarditis being a possible complication of hyperthyroidism was entertained after review of some case reports suggesting a rare relationship between pericardial disease and hyperthyroidism. 4 The earliest case to have been reported was in 1958. Koo et al. 3 reported a case of acute recurrent pericarditis that was presumed to be associated with Graves' disease based on pathological background of the disease and resolution of symptoms following treatment of hyperthyroidism.
There have been different arguments as to whether it is a mere coincidence or a cause-effect relationship. Some authors believe that pericardial involvement in hyperthyroidism may present with pericarditis without effusion, myopericarditis or cardiac tamponade 5 . The general consensus is that, the immunological mechanism which explains pre-tibial, periorbital myxedema and ophthalmic myopathy could be at play in pericardial effusion caused by hyperthyroidism especially in patients with Grave's disease. 6 Autoantibodies or viral infection (Epstein Barr Virus in most cases) involved in Graves' disease can initiate an inflammatory process within the pericardium by interacting with its receptors. [7][8][9][10] Clarke et al. 6 reported four middle-aged patients with Graves' disease associated with pericardial disease. They opined that pericardial disease could be a rare complication of Graves' disease and may have similar mechanism of action with that of Grave's associated ophthalmomyopathy and dermopathy. Most case reports presented typical acute pericarditis who on further evaluation were found to have thyrotoxicosis.
On the other hand, some cases reported the development of acute pericarditis in patients with established diagnosis of Graves' disease on treatment. However, it was suggested that single episodes of pericarditis with Graves' thyrotoxicosis could not explain the pathophysiology, as you would expect that autoimmune forms of pericarditis should be recurrent but this was not the case in most reports. 2 Acute thyrotoxicosis may directly impact pericardial fat metabolism making it a possible alternate cause of pericarditis. 11 In some clinical scenarios, there were cases of drug-induced pericarditis following commencement of propylthiouracil for treatment of thyrotoxicosis. Drug induced vasculitic syndrome was singled out as a possible mechanism 12 . Pericarditis has also been described after the initiation of other anti-thyroid medications like iodine and carbimazole. In patients with pericardial effusion/pericarditis, there is need to rule out hyperthyroidism as a possible aetiology, especially in patients with clinical features that are suggestive. In our case, symptoms resolved following treatment for hyperthyroidism.