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Application of derivative UV spectrophotometry for the determination of enoxacin and nalidixic acid in tablets.

First-, second-, third- and forth-order derivative spectrophotometric methods, using "peak-zero" (P-O) and "peak-peak" (P-P) techniques of measurement have been developed for the determination of enoxacin and nalidixic acid in tablets. The calibration curves were linear in the concentration range of 2.0-12.0 micrograms ml-1 for the analysed quinolones. The procedure was simple, rapid and the results were reliable.