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Breast lesion characterization by a novel nonlinear perturbation approach

We report a novel perturbation approach for time-resolved transmittance imaging in diffusive media. The model relies on the method of Pade approximants and consists in a nonlinear approximation of time-resolved transmittance curves in presence of an inclusion. The ability of the proposed method to quantify tissue optical properties at different wavelengths for reconstruction of tissue constituents was tested on in vivo data of breast lesions from multi-wavelength time-resolved optical mammography