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Acute Ulcers Induced in Canine Stomachs by Endoscopic Compressed Air Delivery of 25 mg NaCl

Abstract: Endoscopic administration of 25 mg NaCl powder to target sites on the gastric mucosa of five dogs, using a compressed air delivery system developed by the author, was followed by observation of changes in the gastric mucosa. After 30 seconds, 1 minute, 2 minutes, 5 minutes and 10 minutes, the sprayed NaCl was washed away by endoscopic water spray, and the presence of submucosal bleeding was observed at the target sites. After 24 hours, ulcers in the gastric mucosa were recognized at sites at which the NaCl had been in contact for 2 minutes or more before being washed away. With one minute or less contact time between NaCl and the mucosa, erosion and redness were observed at the target sites. In a control study, however, no mucosal lesions occurred following identical spray of 25 mg lactose powder which was left in contact for 30 seconds, 1 minute, 2 minutes, 5 minutes and 10 minutes, and also 24 hours.