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Application of 3D Statistical Methods Visualization in the Process of Formulation and Development of Modified Release Tablets with Acetylsalicylic Acid

ABSTRACT The goal of the performed study was an attempt at application of3D statistical methods visualization in the process of formulation of a modified drug release system containing low dose acetylsalicylic acid (ASA) for the secondary prevention of strokes and heart attack as well as further optimization of the desired drug release profile. The obtained raw data was processed by Statistica 8 StatSoft Inc, USA, commercially available software. It was evaluated and confirmed that the main factor influencing the drug release rate of ASA from the model tablets remains the weight ratio of the used polymers. The applied 3D surface plot and 3D contour plot statistical methods gave the opportunity to evaluate the influence of different factors on the release process as well as to chose the most appropriate formulation depending on the target in vitro dissolution profile by utilization of a simple graphic approach. The optimized model formulations will be included in further studies in order to confirm the validity and applicability of the applied tools.