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A9949 Blood Pressure Components and Reduced Kidney Function in Xinjiang Population

Objectives: The association between blood pressure (BP) components (systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP) and mean arterial pressure (MAP)) and reduced kidney function in general population is not well established. In this study, we aim to investigate the association of kidney function with the four BP components among population aged 35–80 years in Xinjiang area, especially with PP and MAP. Methods: We conducted the community-based cross-sectional survey during 2015 to 2017 in 7 sample sites selected by stratified multistage random sampling method from Xinjiang area. 5 291 residents aged 35–80 years were included and 3 888 (73.48%) participants were eligible for analysis. Chronic Kidney Disease (CKD) was defined as an eGFR < 60 ml/min/1.73m2 using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. PP was defined as SBP minus DBP. MAP was calculated as DBP plus one-third PP. Results: The eGFR values differed among the four PP groups. PP, MAP, SBP were negatively associated with eGFR in the correlation analysis and unilabiate linear regression model (all P < 0.05). However, only PP remained significantly in multivariable linear regression model (P = 0.01). Multivariable logistic regression analysis found that PP was associated with CKD after adjustment for various confounders (odds ratio [OR], 1.24, 95% confidence interval [CI], 1.13–1.36), while MAP had no significant association with CKD (OR, 1.02, 95% CI, 0.87–1.19). Conclusion: Of the four BP components, PP is a useful determinant for declined kidney function. PP is an independent risk factor for CKD in general population in Xinjiang area.