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A longitudinal study of the changes in responsiveness of the hypothalamo-pituitary unit to medial preoptic area stimulation and to luteinizing hormone-releasing hormone administration during diestrus-2 and proestrus in rats.

The present studies have examined whether certain components of the preoptico-tuberalpituitary unit show differential changes in responsiveness to activating stimuli during various hours on diestrus day-2 (D2) and proestrus (P) in rats. In Experiment I, the medial preoptic area (MPOA) of Nembutal®-treated 4-day cyclic rats was electrochemically stimulated (ECS), blood was sequentially collected at 30 min intervals to 210 min on various hours during D2 and P, and plasma was radioimmunoassayed for LH/FSH. While MPOA-ECS provoked a significant release of LH in all groups, the peak plasma concentrations varied considerably between 1000 h D2 and 1300 h P. By 2300 h D2, plasma LH rose significantly above baseline but FSH values remained unchanged. At 0300 h P preoptic stimulation induced further significant rises in LH and at this hour plasma FSH also had increased by 200 min poststimulation. While the greatest peak LH concentrations occurred in rats stimulated at 1100-1300 h P, plasma FSH values did not exceed...