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A5104 Significance Of Carotid Artery Doppler Sonography In Preventing And Treating Cognitive Dysfunction In Patients With Hypertension And Coronary Atherosclerotic Heart Disease

Objectives: To analyze the clinical significance of carotid artery doppler sonography in the prevention and treatment of cognitive impairment in patients with hypertension and coronary atherosclerotic heart disease. Methods: A total of 78 hypertensive patients with coronary atherosclerotic heart disease from October 2016 to October 2017 were taken as observation group, and 49 hypertensive patients as the control group. Compared the differences of sex, age, occupation, diet and sleep, smoking history, drinking history, history of diabetes, history of hypertension, body mass index (BMI), total cholesterol (CHO), triacylglycerol (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), intima-media thickness, plaque location and number, and other related levels in two groups. The mini-mental state examination (MMSE) score were used to assessed cognitive function. For those patients with cognitive impairment, The Montreal cognitive assessment (MoCA) were used to assessed cognitive impairment domains. Results: The average score of MMSE in patients with coronary atherosclerotic heart disease was not significantly different from those in control group (P > 0.05), but the incidence of mild cognitive impairment was higher in patients with coronary atherosclerotic heart disease (P < 0.05); The incidence of mild cognitive impairment was significantly higher in patients with more than 3 lesions (P < 0.05). In patients with cognitive impairment, the carotid intima was significantly thicker. (P < 0.05). Conclusion: There is a positive correlation between the blood pressure classification and the risk of cognitive impairment. Carotid plaques affect the occurrence and development of VCI.