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An unusual but distinctive cerebellar formation Part 1

CASE REPORT A 48-year-old Chinese woman with no known medical history was brought into the mortuary for the investigation of sudden death. On autopsy her heart weighed 580 g and cut sections showed left ventricular hypertrophy. Death was attributed to hypertensive heart disease. She was also incidentally discovered to have mild generalised encephalomegaly with a brain weight of 1829 g (mean, 1240 g; corrected for age and sex) and a malformation of the cerebellum (Fig. 1A,B). Cut surfaces of the rest of the brain were normal. In particular, no hydrocephalus or grey matter heterotopia were present. Microscopic sections of the affected areas of the cerebellum are demonstrated in Fig. 2A–D. Histology of the rest of the brain was normal. Also of note was the absence of skin, breast and thyroid lesions. Apart from the left ventricular hypertrophy of the heart, there were no other abnormalities of the thoracic or abdominal viscera.