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The Effect of Dehydroepiandrosterone on Adipose Tissue Cellularity in Mice

Abstract The effect of dehydroepiandrosterone (DHEA) on adipose tissue growth in young adult male mice was investigated. In Experiment 1, mice were individually caged and treated by intraperitoneal injections of DHEA (25 mg/kg body weight, 3x weekly) for 20 weeks. No significant differences in body weight and adipose tissue growth were found. In Experiment 2, DHEA was administered by intubation (450 mg/kg body weight, 3x weekly). In addition, mice were housed either one/cage or five/cage. After 10 weeks of treatment body weight and epididymal and retroperitoneal fat pad weights were significantly decreased in both DHEA groups compared to their respective control groups. In both adipose depots fat cell size was significantly decreased in treated mice while there was no effect on fat cell number. No differences were found in adipose tissue lipoprotein lipase or liver fatty acid synthetase of treated mice.