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Factors relating to sodium excretion in experimental ascites

Although there is some disagreement about the role of the proximal convoluted tubule in the sodium retention of caval dogs, most authors agree that the major site of increased sodium resorption is the ascending loop of Henle. Furthermore, although the majority of experimental evidence suggests that the increase in sodium resorption is caused by alteration in physical factors, presumably in the vasa recti, there is some evidence that circulating substances may also be involved.