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Can the pathologist forecast causation of primary biliary cirrhosis?

Several histopathological and immunohistochemical features of the liver in patients suffering from primary biliary cirrhosis (PBC) indicate a primary destructive process of intrahepatic bile duct segments and suggest an immunologically mediated mechanism for this bile duct loss. Although important progress is being made in the analysis of tissular and cellular changes, it will be apparent that the answer to the question in the title is still speculative: the aetiological trigger remains unknown, and the precise (auto-?) immune mechanisms of bile duct destruction still remain elusive.