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In Vitro Inhibition of Arachidonate Metabolism by some Alkamides and Prenylated Phenols.

We have recently screened plant constituents for inhibitory effects on arachidonate metabolism and have found some arachidonic acid analogues such as capsaicin of Capsicum annuum L. and the ajones of Allium sativum L. to be powerful in vitro inhibitors of prostaglandin synthase (CO) and 5-lipoxygenase (5-LO). In continuation of this screening program we have extended our investigations to some naturally occurring alkamides and alkylated phenol derivatives