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Strand invasion properties and serum stability of alpha-tricyclo-DNA.

beta-tricyclo DNA (tcDNA) is a third generation antisense oligonucleotide developed and studied extensively in our laboratory. We recently became interested in the pairing properties of its alpha-anomeric form and observed parallel duplex formation with natural DNA and RNA. These duplexes were of the same level of thermal stability as their natural counterparts. In addition alpha-tcDNA exhibited poor thermal stability of antiparallel duplexes within its own backbone series which makes it a candidate for double strand invasion applications. Here we report on the strand invasion properties of alpha-tc-DNA and its stability in human serum.