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STUDIES ON T H E PATHOGENESIS OF ACUTE I N F L A M M A T I O N I. THE IN'FI,AMMATORY REACTION TO THERMAL INJURY AS OBSERVED IN THE RABBIT EAR CHAMBER

The principal cellular events which constitute the phenomena of inflammation have been clearly described in the classical works of Addison (1), Waller (2), Cohnheim (3), and Metchnikoff (4). More recent observations have been made with refined techniques by Clark and Clark (5, 6), Florey et al. (7), and Zweifach (8). In spite of these and many other detailed investigations, knowledge of the subject remains essentially descriptive. The underlying biochemical and biophysical reactions have not been clearly defined. The experiments reported in this and the following paper concern the antiinflammatory properties of cortisone as they pertain to the mechanisms of acute inflammation. Preliminary exploration of this problem revealed the necessity of designing a special method for producing an acute inflammatory reaction which could be made highly reproducible and could be visualized directly in ~ivo. A detailed account of the technique finally adopted and the response which it regularly evoked is presented in this report. The paper that follows relates to the ways in which the inflammatory reaction was found to be affected by adrenocorfical hormone.