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Labor division of rats under the influence of prolonged administration of (-) 9 -trans-tetrahydrocannabinol.

The effects of a prolonged administration of 5 mg/kg of (–) △9-trans-tetrahydrocannabinol (△9-THC) on a labor division between pairs of rats were studied. 12 such pairs were previously trained in a modified Skinner box up to the point when one animal of each pair did most of the bar-pressing (worker rat) while the partner obtained most of the reward (nonworker). In 7 of the 12 pairs tested, the drug administered to worker rats was able to promote an inversion of the hierarchy previously established. Thus, worker rats under Δ9 -THC action behaved as nonworkers. This inversion was transitory in 5 pairs and irreversible in the remaining two, even when the drug was discontinued.