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Inhibition of Yeast Multiplication by Hypocholesteremic Compounds and its Annulment by Lipids 1

Summary The hypocholesteremic compounds, benzmalecene and triparanol, inhibited the multiplication of the yeast, Saccharomyces cerevisiae, and this inhibition was annulled by lecithin, oleic acid, lauric acid, ergosterol, and squalene in that order. Saturated fatty acids, other sterols, and sterol precursors were ineffective. The implications of these results for uncovering unsuspected metabolic targets and side-effects of drugs in humans is discussed.