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The Influence of Starvation Upon Hepatic Drug Metabolism in Rats, Mice, and Guinea Pigs

Summary Male rats, mice, and guinea pigs were starved for 1, 2, or 3 days; and the metabolism of ethylmorphine, p-nitroanisole, and aniline was studied. The metabolism of aniline was stimulated by starvation in mice, rats, and guinea pigs; the metabolism of p-nitroanisole was stimulated only in mice and rats; and the metabolism of ethylmorphine was stimulated by starvation only in mice. The results suggest that the oxidative enzyme systems studied are not interdependent, and the pathways studied appear to be species dependent.