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Ototoxic effects of gentamicin and kanamycin in the guinea-pig [proceedings].

Then acrolein (1.7 mg/kg) was infused as previously into all these rats and the livers examined 24 h later. Pretreatment with allyl alcohol made no difference to the severity or incidence of macroscopic liver lesions after intraportal acrolein infusion. A repeat experiment gave the same result. The experiments were unable to confirm that the acquired tolerance to allyl alcohol was mediated by increased detoxification of acrolein, but do not preclude this possibility since the affects of acute intraportal infusion may have overridden any mildly induced mechanism for acrolein disposal. Alternatively, the increased tolerance may be due to a decreased production of acrolein from allyl alcohol, possibly due to a reduction in the activity of alcohol dehydrogenase (Serafini-Cessi, 1972).