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Antioxidants and the prevention of preeclampsia--unresolved issues.

Preeclampsia is a pregnancy-specific, multisystem disorder that can have considerable adverse effects on the mother and the fetus. In developing countries, preeclampsia is a major cause of death among pregnant women.1 In the United States, 15 percent of premature births and their attendant complications are attributable to preeclampsia.2 Thus, numerous strategies intended to prevent preeclampsia — such as the use of antiplatelet agents and supplementation with calcium — have been studied, but without success.3,4 More recently, antioxidants have been proposed as a potential preventive strategy on the basis of data suggesting that endothelial dysfunction is fundamental to the development . . .