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Host STING is essential for the efficacy of anti-PD-1 inhibitors in non-small cell lung cancer.

The stimulator of interferon genes (STING) pathway is important for anticancer immune responses. However, the relative contributions of host and tumor STING in anti-PD-1 (programmed cell death protein 1) inhibitor responses in NSCLC are unknown. STING expression in tumor and blood was associated with anti-PD-1 therapy in non-small cell lung cancer (NSCLC) patients; Moreover, loss of PD-1 inhibitor therapeutic potency was demonstrated in STING KO splenocytes and STING KO mice. STING knockdown in tumor cells had no effect. STING on CD8+ T cells and host cells, not tumor cells, correlated with clinical effect of Anti-PD1 therapy in NSCLC patients. Finally, adoptive transfer of CD8+ T cells restored PD-1 inhibitor anticancer effects. STING in host cells but not in tumor cells, mediates anti-PD-1 inhibitor responses in cancer immunotherapy and could be used to select advantageous NSCLC patients from immunotherapy.