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A Review of the Characteristics, Properties and Methods for Quantification of Roxithromycin



Roxithromycin is one of the most frequently used macrolide antibiotics, a safe group of
antimicrobials, that acts against Gram-positive bacteria and some Gram-negative bacteria. It is sold
in several countries in different dosage forms (tablets and capsules) and strengths (50, 100, 150 and
300 mg). Several analytical methods have been described to quantify roxithromycin in different matrices,
such as biological and environmental samples and food. Identifying the main characteristics
of the drugs and selecting appropriate analytical methods for their quantification are of paramount
importance for understanding the behavior of drugs, metabolites and impurities. This review presents
the physical-chemical and microbiological characteristics, properties as well as methods for
quantification of roxithromycin in biological fluids, pharmaceutical preparations, food and environmental
samples. HPLC coupled to various detection systems is the most used analytical technique
to determine roxithromycin in these matrices. Although many analytical methods have been reported
for the analysis of this drug, it is very important to include in this context a prospective view to
implement new analytical technologies for the quality control of this antimicrobial that contributes
to the preservation of economic and environmental impacts.
