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Simple and Efficient Detection Approach of Quercetin from Biological Matrix by Novel Surface Imprinted Polymer Based Magnetic Halloysite Nanotubes Prepared by a Sol-Gel Method.

Molecular imprinted polymers coated magnetic halloysite nanotubes (MHNTs-MIPs) were prepared through sol-gel method by using quercetin (Que), APTES and TEOS as template, monomer and cross-linker agent, respectively. The synthesized MHNTs-MIPs were characterized by fourier transform infrared, scanning electron microscope, transmission electron microscope, XRD and vibrating sample magnetometer. Various parameters influencing the binding capacity of the MHNTs-MIPs were investigated with the help of response surface methodology. Selectivity experiments showed that the MHNTs-MIPs exhibited the maximum selective rebinding to Que. Therefore, the MHNTs-MIPs was applied as a solid-phase extraction adsorbent for the extraction and preconcentration of quercetin and luteolin in serum and urine samples. The limits of detection for quercetin and luteolin range from 0.51 to 1.32 ng mL-1 in serum and from 0.23 to 1.05 ng mL-1 in urine, the recoveries are between 95.20 and 103.73% with the RSD less than 5.77%. While the recovery hardly decreased after several cycles. The designed MHNTs-MIP with high affinity, sensitivity and maximum selectivity toward Que in SPE might recommend a novel method for the extraction of flavonoids in other samples like natural products.