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S3217 Demography of Acute Pancreatitis Among Cannabis Users: Retrospective Nationwide Cohort Analysis

difficult to control symptoms. Opioids have been found to be effective for symptom management in some patients with CP, however, these medications can cause multiple side effects including addiction. There is a paucity of studies that evaluate the effect of sex, race, insurance status, hospital length of stay (LOS), mortality, and total hospital charges for patients with CP. The aim of this study was to identify key risk factors in a national population cohort (in the USA) admitted to hospitals between the years 2012 through 2018. Methods: All patients aged 18 years and above in this patient population were identified from the US Nationwide Inpatient Sample (NIS). Multivariate regression analysis was used to estimate the odds ratios of in-hospital mortality, the average length of hospital stay, and hospital charges, after adjusting for age, gender, race, primary insurance payer status, hospital type and size (number of beds), hospital region, hospital teaching status, and other demographic characteristics. Results: Our study identified approximately 220,331 patients who had been admitted with CP, 9,105 were admitted with CP and opioid use disorder versus 211,226 patients with CP without opioid use disorder. The analysis revealed that the average age was 47.96. Furthermore, Mortality was decreased [OR 0.55 (0.44-0.68), p , 0.0001] for patients with CP and opioid use disorder but LOS was slightly increased [OR 1.02 (1.01-1.03), p , 0.0001]. Independent positive predictors of mortality were the presence of portal hypertension [4.22 (1.62-10.97), p , 0.003] and Hepatorenal Syndrome (HRS) [10.68 (2.03-56.24), p , 0.005]. Conclusion: Interestingly, patients with CP taking opioids had decreased immediate mortality and increased LOS. This reveals that the use of opioids for the management of pain associated with CP isn’t completely detrimental but also demonstrates that these patients require an increased length of stay which could potentially increase the economic burden on the healthcare system. Randomized trials are needed to further study the association between CP, opioid use, and the impact on morbidity and mortality.