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Activation of GPR81 Causes Endothelin‐A Receptor‐Dependent Cardiorenal Effects

G protein‐coupled receptor 81 (GPR81) is highly expressed in adipocytes and activation by the endogenous ligand lactate or by the specific agonist AZ’55381 inhibits lipolysis. The receptor is also found in non‐adipose tissue2 but the function here is not well understood; recent studies show that GPR81 activation increases blood pressure1.