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Polymorphisms at the angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R) loci and normal blood pressure

The M235T polymorphism at the angiotensinogen (AGT) locus and the A1166C polymorphism at the angiotensin II type 1 receptor (AT1R) locus have been reported to be associated with hypertension in several populations. We examined these polymorphisms in three samples of healthy Norwegians with respect to normal blood pressure (BP) levels. None of the genotypes defined by the polymorphisms or their combinations were associated with systolic (S) BP (SBP) or diastolic (D) BP (DBP) level. However, there was a trend in all three series that individuals carrying the C allele of the A1166C polymorphism at the AT1R locus (homozygotes as well as heterozygotes) had higher SBP, than AA homozygous individuals. The observation did not reach statistical significance in any of the series. When examining these two polymorphisms with respect to possible variability gene effects on BP in two series of monozygote (MZ) twin pairs, no such effect was detected. We could not detect any interaction between the loci studied with respect to BP level or variability. Thus, neither the AGT locus nor AT1R locus, separately analysed or together, seem to have variability gene effects or definite level gene effects on normal BP.