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Comparison of two nanocarriers for quercetin in morphology, loading behavior, release kinetics and cell inhibitory activity

Recently, nanocarrier loading drugs have caused widespread concern. However, there are few reports about comparison of drug loading behavior of different nanoparticles. In this study, we prepared two nanocarriers (starch nanoparticles and F127 nanoparticles) for oral and intravenous
 injections, respectively. We used dynamic light scattering and transmission electron microscopy to study the morphology of the nanocarriers. Moreover, the loading behavior of nanoparticles on quercetin (QC) and the release behavior of nanoparticles at different pH levels were studied. In artificial
 gastric (pH 2.0) and intestinal (pH 6.8) juices, QC showed a sustained release in two nanoparticles. Meanwhile starch nanoparticle-QC and F127-QC nanosystems both showed relatively higher inhibitory activities than free QC on five kinds of cells, especially for cell A549, the cell inhibition
 ratio achieved to 55.16% and 64.06%, respectively. This study provided a reference for oral and injection of drug-loaded nanoparticles.