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TRANSPLANT OF MESENCHYMAL STEM CELLS FROM ADIPOSE TISSUE: OBTAINMENT, STANDARTIZATION AND APPLICATION

The work determines the standard conditions for the obtainment of a transplant of mesenchymal stem cells from adipose tissue for the clinical application as co-transplant in allogenic transplantation of hemopoietic stem cells. To ensure the safety of the transplant besides its quality control, including morphologic and immunophenotypic tests, the results of microbiological tests and viability test were necessary in the categorization of mesenchymal stem cells. The registration certificate, devised earlier for the systematization of data on the transplant was drawn, when the mesenchymal stem cells from adipose tissue were distributed for the therapy. Nineteen transplants of the mesenchymal stem cells from the adipose tissue were prepared by this protocol for the clinical application. They were successfully used as co-transplants in the allogenic transplantation of hemopoietic stem cells and in the therapy of reaction Transplant Against Host in patients with oncohematological pathology in Minsk Municipal Clinical Hospital No.9.