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Recombinant Peptide Fusion Protein‐Templated Palladium Nanoparticles for Suzuki‐Miyaura and Stille Coupling Reactions

This study examined the use of nanoparticles created with recombinant 45‐amino acid long peptides fused to green fluorescent protein (GFPuv) to catalyze twelve representative Suzuki‐Miyaura and Stille coupling reactions. A method was developed to prepare powders (Pd@GFP) containing protein and synthesized nanoparticles. Next, coupling reactions were performed in a green solvent without nanoparticle purification. Pd@GFP had high turnover frequencies for the synthesis of model compounds including lapatinib (Tykerb®) and could be recycled. This study establishes a potentially cost‐effective approach to prepare heterogeneous catalysts containing well‐defined nanoparticles enabling key C−C bond formation leading to synthetically and pharmaceutically interesting compounds.