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[Effects of angiotensin II on proliferation and expression of interleukin-6 of human kidney fibroblasts].

OBJECTIVE
To investigate the effects of Angiotensin(Ang) II on the proliferation and expression of Interleukin (IL)-6 in human kidney fibroblasts(KFB).


METHODS
The human KFB were cultured and identified, the proliferation of KFB was measured by MTT, and the level of IL-6 was measured by radioimmunoassay(RIA).


RESULTS
Angiotensin II could stimulate the proliferation of KFB and enhance the expression of IL-6 in protein level on KFB.


CONCLUSION
Angiotensin II can stimulate KFB's proliferation and enhance the expression of IL-6 of KFB. These findings suggest that Ang II might play a part in the mechanisms for modulating tubulointerstitial changes and induceing renal fibrosis.