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Profile, mean residence time of ACTH and cortisol responses after low and standard ACTH tests in healthy volunteers

Objective  No consensus exists until now about the suitable dose of tetracosactin in the ACTH stimulation test for detecting adrenal insufficiency. Our aim was to characterize both the ACTH(1–24) and the cortisol profiles after standard high‐dose test (250 µg) (HDT) and low‐dose test (1 µg) (LDT) in healthy subjects in order to provide a deeper knowledge about the relationship between stimulus and response.