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Blood amino acids in the pregnant mare and fetus: the effects of maternal fasting and intrafetal insulin

Blood amino acids were measured in twelve chronically catheterized mares and fetuses between 250 and 310 days gestation. The concentrations of the majority of individual amino acids were similar in maternal and fetal arterial blood and no gestational changes were detected. Only methionine, phosphoserine, 3‐methyl‐histidine and glutamine were consistently higher in the fetus than the mare, whilst certain other amino acids were higher in the maternal blood. Fasting the mares for 36 h led to significant falls in plasma glucose and rises in urea and maternal free fatty acids (FFA). Small but significant decreases in a few amino acids were seen in both fetus and mother, with an overall amino acid fall of 15% in the fetus and 13% in the mare. Virtually all amino acids had risen to basal values by 6 h after feeding. Intrafetal insulin (1 i.u./kg I.V.) as a bolus caused a more dramatic fall in fetal glucose than fasting, with no change in the mare. There were also rapid decreases in many amino acids by 30 min post‐insulin and by 2 h all but five amino acids had fallen significantly. There was a drop in total fetal blood amino acids of 29%. These findings show that, in contrast to most other species studied, there is no overall feto‐maternal gradient in blood amino acids in the mare, and that fasting leads to small falls in amino acid concentration, whereas intrafetal insulin induces a severe hypoglycaemia with dramatic decreases in almost all amino acids and no change in urea, suggesting a direct anabolic effect of insulin on fetal tissues.