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5‐HT6 receptor antagonist SB‐271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex

The present study investigated the neurochemical effects of the selective 5‐HT6 receptor antagonist SB‐271046 in the rat medial prefrontal cortex (mPFC). The effect of SB‐271046 on extracellular levels of dopamine (DA), norepinephrine (NE), and serotonin (5‐HT) in the mPFC was examined using in vivo microdialysis in the freely moving rat. SB‐271046 (10 mg/kg, p.o.) produced a significant increase in extracellular levels of both DA and NE without altering 5‐HT neurotransmission. These results further support the rationale for the use of 5‐HT6 receptor antagonists in the treatment of cognitive dysfunction associated with psychiatric diseases. Synapse 51:158–164, 2004. © 2003 Wiley‐Liss, Inc.