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Liposarcomatous differentiation in malignant phyllodes tumours is unassociated with MDM2 or CDK4 amplification

Breast sarcomas are rare, usually occurring in the setting of malignant phyllodes tumour (MPT). Heterologous differentiation commonly resembles well‐differentiated or pleomorphic liposarcoma. In extramammary sites, these subtypes have different biological behaviours and distinct genetic alterations: MDM2 and CDK4 amplification in well‐differentiated liposarcoma, and polyploidy with complex structural rearrangements in pleomorphic liposarcoma. The aim of this study was to investigate foci resembling well‐differentiated liposarcoma in MPT for MDM2 and CDK4 amplification.