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In vivo genotoxicity studies with p‐benzoquinone dioxime

P‐Benzoquinone dioxime (BQD) appears to be a sex‐specific rat carcinogen inducing tumours of the urinary bladder in female rats. The present paper shows that BQD is a direct‐acting mutagen in Salmonella typhimurium TA98, confirming published data. In contrast to this in vitro data, negative results were obtained after oral administration of BQD to female rats in both the bone marrow micronucleus test and the in vivo liver UDS test.