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Diagnosis of recurrent rheumatic heart disease and its gradation in severity

The aim of the work was to develop diagnostic criteria for recurrent rheumatic heart disease and its variants differing in severity. To solve this question we used a complex of clinical, laboratory, instrumental data, as well as the results of pathological anatomical examination. WHO criteria with determination of streptococcal antibody titers were used during examination of soles. Besides routine methods of laboratory study, the state of body's immune system was evaluated: reaction of inhibition of leukocyte migration (RTML), titer of anti-streptococcal antibodies, measures of completed and incomplete phagocytosis, activity of blood serum acid phosphatase. The type and group of streptococcus were determined in nasopharyngeal smears. ECG and Echo-CG were recorded. The state of central hemodynamics was studied with mechanocardiography according to N.N. Savitsky.