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[Effect of dimethylformamide on the microsomal hydroxylation system in the liver of rats fed diets with different fat contents].

The authors studied the effect of the universal aprotonic solvent dimethylformamide (DFA) on liver microsomal hydroxylation of male rats fed diets with different fats (sunflower oil or lard). DMFA given in a dose of 200 mg/kg bw per os for 4 weeks produced a considerable reduction in cytochrome P-450 content in liver homogenates and microsomes and a lowering of the activity of N-demethylation in microsomes with amidopyrine, ethylmorphine and DMFA being used as substrates. The degree of inhibition of the demethylase reactions and liver cytochrome P-450 content was more demonstrable in rats fed the diet containing sunflower oil as compared with animals whose diet contained lard. During DMFA intoxication, the rate of spontaneous formation of malonic dialdehyde in liver homogenates of rats given sunflower oil was considerably higher than in rats fed the diet with lard. Remarkable coproporphyrinuria was revealed during DMFA intoxication which was more pronounced in rats fed the diet containing sunflower oil. It was demonstrated that the lard-containing diet was marked by a higher vitamin E/polyunsaturated fatty acids ratio (mg/100 g) with regard to alpha-tocopherol acetate added to the diet as compared to the sunflower oil-containing diet. The role of antioxidant properties of the diets in modification of the hepatotoxic action of DMFA is discussed.