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Toward a targeted treatment for addiction

Cocaine-induced synaptic plasticity can be reversed in mice with optogenetically inspired deep brain stimulation A major challenge in treating many neuropsychiatric disorders is that diagnoses are regularly based on behavior rather than on biomarkers, as well as the fact that such conditions are often not associated with gross structural brain changes. Addiction is one example of a disorder defined by pathological behavior (drug seeking despite harmful consequences) in which there is no significant loss of neurons and for which there is no cure.