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Selected highlights from other veterinary journals

IdIopathIc inflammatory bowel disease (IBS) is the most common cause of chronic intestinal disease in dogs and results in a range of often debilitating clinical signs. the pathogenesis of IBd in dogs is not completely understood; however, there is evidence that oxidative stress (an imbalance between the production of reactive oxygen species and their removal by antioxidants) plays an important role in the pathogenesis of IBd in people. this study aimed to compare the antioxidant response and oxidative stress response in dogs with and without IBd, using a panel of serum biomarkers. Serum samples obtained from 18 dogs with IBd and 20 healthy dogs were included in the study. trolox equivalent antioxidant capacity (tEac), cupric reducing antioxidant capacity (cUpRac), ferric reducing ability of the plasma (FRap), total thiol concentrations, and paraoxonase 1 (poN1) activity were evaluated in serum to determine the antioxidant response. to evaluate oxidative status, ferrous oxidation-xylenol orange (FoX), thiobarbituric acid reactive substances (tBaRS) and reactive oxygen species production (RoS) concentrations in serum were determined. Mean concentrations of all antioxidant biomarkers analysed, with the exception of FRap, were significantly lower in the sera of dogs with IBd than in healthy dogs. the oxidant markers studied were significantly higher in the sera of dogs with IBd than in healthy dogs. the authors suggest that antioxidants (which act to control oxidative stress) are decreased, and oxidants (generated in association with oxidative stress) are increased, in dogs with IBd. they conclude that their findings could help to explain the pathophysiology of the disease and biomarkers might be useful in evaluation of the oxidative stress response in dogs with IBd.