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Evaluation of an Automated Sample Preparation System for Analysis of Methacrylates in Saliva

Various studies have shown that components from composite resins, which are widely used in dental filling materials, can leach out into the oral cavity. Investigations of these leachable methacrylate monomers in saliva are limited by sample throughput and time due to an elaborate sample preparation process. Hence it was the goal of the current study to develop and evaluate an automated SPE procedure for sample preparation for determination of methacrylates in saliva. The sample pre-treatment by solid phase extraction (SPE) is a common method for concentration and isolation of the analyte from a specific matrix. After preparation of samples, the methacrylates were quantified using gas chromatography-mass spectrometry (GC-MS). The presented results indicate that the developed automated SPE method has clear benefits compared to a manual SPE method and can be used for routine analysis of methacrylates in saliva.