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Intrahepatic cholangiocarcinoma arising from HBV infection may be a highly selected population for liver transplantation

the one used by Rao et al. (1 lg/mL for 6 hours in bone marrow–derived macrophages). These differences in experimental conditions may have contributed to the different results between the two studies. In our article, we also mentioned mechanisms other than ER stress that may modulate Nogo-B’s involvement in M2 polarization and highlight the need for further investigation. Advances in macrophage characterization beyond simple M1 and M2 phenotypes also add complexity and leave no doubt that the role of ER stress in macrophage polarization/differentiation needs to be scrutinized.