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Control of neuroblastoma cell proliferation and differentiation by human bone marrow

Neuroblastoma (NB) is one of the few tumors known to undergo spontaneous regression. Its progression, however, often leads to bone marrow (BM) metastasis. Proliferation and differentiation of human NB cells may be regulated in vitro by a variety of biologic agents, some of which are released by low‐density BM and peripheral blood (PB) cells. Little is known regarding BM cell‐derived control of NB cell growth and differentiation.