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[A pathohistological study on experimental brucellosis in inbred mice].

A pathohistological study was carried out in BALB/C and C57/BL inbred mice models infected with B. melitensis, B. abortus, and B. suis respectively. The results showed that a chronic pathological lesion was developed due to repeated infectious processes occurred in various organs at different stages of brucella infection. Significant pathological changes was observed in the reticuloendothelial system including the lymphocytes, spleen and liver etc. and less remarkable changes were seen in the lung, heart and kidney in sequence. Comparing the pathological changes induced by the three species of brucella infection, lesions developed in BALB/C was more remarkable and the pathological change induced by B. abortus infection was the most significant in both BALB/C and C57/BL mice.