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Buspirone induced prolactin responses in obsessive‐compulsive disorder (OCD): is OCD a 5‐HT2 receptor disorder?

&NA; Buspirone (BUSP) is a serotonergic (5‐HT) agonist with activity at the 5‐HT1A receptor. The BUSP induced prolactin (PRL) response was examined in 10 patients with a DSM IIIR diagnosis of obsessive‐compulsive disorder (OCD). The results were compared with PRL responses to BUSP found in 10 age and sex matched healthy controls. The results suggest that the 5‐HT1A receptor dysfunction may not be involved in the pathophysiology of OCD. The authors review the literature and consider the hypothesis that in OCD a complex interaction of other 5‐HT receptor sub‐types may be occurring, possibly with dysfunction primarily of the 5‐HT2 receptors.