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The effect of propanidid on myocardial blood flow and oxygen consumption in the dog.

Using the xenon-133 clearance technique for measurement of myocardial blood flow, it was shown that propanidid produced a large but transient increase in myocardial oxygen availability in the dog. With 5 mg/kg and 10 mg/kg, myocardial blood flow rose by 26% and 75% respectively, independent of any change in perfusion pressure, cardiac output or myocardial oxygen consumption. Cremophor-EL was found to have no effect on myocardial blood flow.