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Biclustering of DNA Microarray Data: Theory, Evaluation, and Applications

In this chapter, different methods and applications of biclustering algorithms to DNA microarray data analysis that have been developed in recent years are discussed and compared. Identification of biological significant clusters of genes from microarray experimental data is a very daunting task that emerged, especially with the development of high throughput technologies. Various computational and evaluation methods based on diverse principles were introduced to identify new similarities among genes. Mathematical aspects of the models are highlighted, and applications to solve biological problems are discussed. Panayiotis V. Benos University of Pittsburgh, USA