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Pharmacokinetics and dose requirements of disopyramide in neonates and children

The pharmacokinetics and dose requirements of disopyramide were evaluated in 10 infants and children during the course of routine therapeutic drug monitoring. Drug clearance was estimated using a Bayesian parameter estimation program and found to range from 0.09‐0.31L/h/kg. Concentrations associated with a satisfactory response were achieved with doses of 15‐20mg/kg/day in most patients, but some required higher doses of 25‐30mg/kg/day.