{'fraction_non_alphanumeric': 0.0328879753340185, 'fraction_numerical': 0.020554984583761562, 'mean_word_length': 5.324675324675325, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Amplification on double‐minute chromosomes and partial‐tandem duplication of the MILL gene in leukemic cells of a patient with acute myelogenous leukemia

Partial‐tandem duplication (PTD) of an internal portion of MLL occurs in some cases of acute myelogenous leukemia (AML) with trisomy 11 or a normal karyotype. This type of MLL rearrangement may be transcribed into an mRNA species that is capable of encoding a partially duplicated protein associated with leukemogenesis. However, although several kinds of oncogenes, especially MYC, are often amplified on double‐minute chromosomes (dmins) in hematological malignancies, no amplification of MLL has been reported in AML. Here, we report the first documented case of a patient with AML whose leukemic cells exhibited amplification of MLL on dmins. Furthermore, in this patient, MLL was rearranged in a PTD manner, with in‐frame fusion of exons 2 and 6. Genes Chromosomes Cancer 23:267–272, 1998. © 1998 Wiley‐Liss, Inc.