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The Role of Phospholipases A2 in Eicosanoid Generation and Airway Inflammation

The mammalian genome encodes several secreted phospholipases A2 and cytosolic phospholipase A2. All of these enzymes have been obtained in recombinant form and their in vitro interfacial enzymatic properties studied. Inhibitors of these enzymes are being developed by structure‐based approaches. Mice deficient in each of the phospholipases A2 are available or being prepared.