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Pharmacokinetics of halofantrine in healthy Thai volunteers.

Halofantrine has been shown to be highly effective against multi-drug resistant falciparum malaria in Thailand (Boudreau et al., 1988). We have demonstrated that the pharmacokinetics of halofantrine in Thai patients with malaria are different from those in Caucasian volunteers (Karbwang et al., 1991). As both ethnic and disease-related factors might contribute to the differences observed we now report on the pharmacokinetics of halofantrine in healthy Thais. Eight male volunteers, aged 15 to 60 years, with a weight range of 45-60 kg, and no history of liver or kidney diseases were recruited. No other drugs were taken concurrently and written informed consent was obtained. The study was approved by the Ethics Committee of the Faculty of Tropical Medicine, Mahidol University. On admission, each subject had a physical examination, routine blood and blood chemistry investigations, urinalysis and ECG. All subjects were admitted into the Bangkok Hospital for Tropical Diseases for 2 days and returned for follow-up daily for 1 week then weekly until day 35. Dosage with rac-halofantrine hydrochloride (500 mg) was at 6 h intervals for three doses with haematological examinations and biochemical