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Pharmacokinetic comparison of two carbamazepine slow‐release formulations

In a single‐blind pharmacokinetic study patients being treated with conventional carbamazepine (CBZ) in a t.i.d. regimen were randomly allocated to identical doses of two CBZ slow‐release formulations (Trimonil Retard® and Tegretol Retard®) administered once daily. Statistical analysis involved the following parameters: AUC, Cmin, Cmax and Fluctuation Index (FI). With regard to Cmin and FI statistically significant differences in favour of Tegretol Retard® were observed.