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Autoradiographic distribution of [3H]YM‐09151‐2, a high‐affinity and selective antagonist ligand for the dopamine D2 receptor group, in the rat brain and spinal cord

We determined the regional distribution of the dopamine D2 receptor group in the rat central nervous system by quantitative receptor autoradiography with a high‐affinity and selective antagonist, [3H]YM‐09151‐2. Saturation and competition experiments demonstrated that the binding of [3H]YM‐09151‐2 to striatal sections was saturable (Bmax=37.3 fmol/section), of high affinity (Kd=0.315 nM), and was inhibited selectively by prototypic D2 ligands.