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Acrolein‐Induced Epigenetic Modification of Histone 3 in Rat Vascular Smooth Muscle Cells

Environmental pollutants can exacerbate disease conditions by affecting chromatin structure and ultimately regulating gene expression. Acetylation of histone lysine has been reported to contribute to gene expression while the methylation results in gene inactivation. Acrolein, an environmental pollutant and a major component of cigarette smoke, has been implicated in cardiovascular toxicity and several neurological disorders such as Alzheimer's disease. N‐acetyl cysteine (NAC), a precursor of glutathione transferase, has been reported to prevent acrolein toxicity in cell culture. The goal of the present study was to investigate the effects of acrolein on modification of histone 3, lysine 9 residue (H3K9) in rat's vascular smooth muscle cells (VSMCs) in the present and absent of NAC.