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COMPARATIVE EFFICACY AND SAFETY OF SYSTEMIC TERBINAFINE AND ITRACONAZOLE IN RECALCITRANT TINEA CRURIS

Background: The prevalence of recalcitrant tinea is increasing despite available treatment options. Itraconazole and terbinane are the most
commonly prescribed agents for tinea. The relative efcacy of both the drugs is under focus and no standard guidelines exist for the recalcitrant
tinea.
Objective:To compare their relative efcacy and safety of itraconazole and terbinane in recalcitrant tinea cruris patients.
Methods: A prospective, randomized, open label study recruited 100 recalcitrant tinea cruris patients of 18-65 years age at dermatology OPD at
GNDH hospital, Amritsar, India after obtaining Institutional Ethics Committee approval.
Patients who consented for study and follow up were included. Impaired hepatic/ renal function, secondary bacterial infections or deep mycoses
patients were excluded. After randomization, group Acomprised of 50 patients who were put on capsule itraconazole 100 mg BD and group B of 50
patients on tablet terbinane 250 mg OD for eight weeks.
The treatment response was assessed as Complete cure, Treatment failure based on clinical (PGAScore) and mycological (KOH Smear) prole.
Results: Itraconazole resulted in complete cure in 28 patients whereas terbinane cured 14 patients completely (p <0.05). Treatment failure were
observed as 1 and 8 (itraconazole and terbinane respectively, p < 0.05). Both drugs had comparable safety prole with no serious adverse effects.
Limitations of the study were short duration, small sample size and non-blinding.
Conclusion:Itraconazole seems relatively more efcacious than terbinane in the treatment recalcitrant tinea cruris cases