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The Renal Physiome Project

We discuss current progress towards two complementary web resources being developed for the Renal Physiome: (1) a database (QKDB) for quantitative and anatomical data at all levels of kidney organization, including molecular-level information on membrane channels and transporters, structural and functional parameter values at the epithelial level, measured flows and concentrations along vessels and nephron segments, anatomical data (including imaging studies) at all scales, etc.; and (2) an interactive interface to mathematical models of kidney structure and function, built around a zoomable 3D virtual unilobed kidney. These resources will facilitate interaction among renal modelers, experimental laboratories, and clinical researchers