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A Clinical Evaluation Comparing the Bioavailability of Two Buffered Vitamin C Supplements in Healthy, Non‐smoking Males.

To determine and compare the relative bioavailability of vitamin C (AA) from Comfort C® and Ester‐C® in healthy, non‐smoking, young males. Methods: Five males (32.0 ± 6.2 years) received a single, 1 gram dose of AA from 2 different AA products in random order, EACH dose preceded by at least 7 days of a low AA diet. Blood was drawn pre‐ingestion and 30, 60, 90, 120, 210 and 240 minutes post‐ingestion for serum AA analysis by HPLC. Average urine concentrations of AA were determined by twenty‐four hour collection and HPLC analysis.