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Giant basal cell carcinoma of the left lateral neck

Basal cell carcinoma is a malignant epithelial neoplasm of the skin and the most common human skin cancer. It is generally associated with a good prognosis. In this case report, a giant basal cell carcinoma of the nodulo-ulcerative type showing wide ulceration with marginal multiple small nodules, is presented. It was trapezoidal in shape, having dimensions of 7 cm at the greatest basal width, 6 cm vertically with different anterior and posterior margin dimensions, and 5 cm horizontally at the top margin. After wide excision of the lesion including 5–10 mm safety margins, the wound was reconstructed with a local skin flap and split-thickness skin graft. The reconstructed wound healed well without recurrence for 1 year.


INTRODUCTION
Basal cell carcinoma (BCC) and squamous cell carcinoma account for 77% and 20%, respectively, of all skin cancers, with melanoma and rare tumors constituting the remaining 3% [1]. Among the rare tumors it has been reported that the incidence of giant basal cell carcinoma (GBCC) was 0.5% of all basal cell cancers [2]. GBCC is defined as a lesion greater than 5 cm in its longest dimension through the center, independent of histological subtype, local invasion, or metastasis [3]. The American Joint Cancer Committee classifies GBCCs as T3 tumors [4,5]. Typically, BCCs are characterized by slow growth, minimal local invasiveness, lower morbidity, and a high cure rate. In contrast, GBCC is a rare and aggressive form of BCC, which usually carries a higher risk of complications and mortality [6,7].
Further in contrast to BCCs, GBCCs often occur on skin that is less exposed to sunlight, such as the back, shoulders, legs, and thighs [8]. The growing tumor is often accompanied with ulcer-ation and necrosis [9] and GBCC of the head and neck in particular, is often accompanied with ulceration and bad odor [2].
Here, we report a case of GBCC involving the left lateral neck and mandibular border.

CASE REPORT
A 74-year-old man visited the plastic surgery department with a wide nodulo-ulcerative lesion on the left lateral neck and mandibular border. The patient had been presented a small palpating mass on his left upper neck 14 years ago. However, he did not undergo surgery at the time for socioeconomic reason. Over the past 3 years, the mass grew rapidly with central ulceration and minor discharge from the ulcerated wound.
Physical examination revealed a wide ulcerated lesion covered with an unwashed, infected pseudomembrane. Multiple small nodules were found along the margin. The inferior margin of the lesion was located on the left lateral mid-neck and was 7 cm in its greatest dimension. The posterior vertical margin was about 6 cm and located 1.5-2.5 cm anteriorly to the lateral hairline of the occipital scalp. The anterior vertical margin was located at the lateral cheek along the posterior mandibular border

Giant basal cell carcinoma of the left lateral neck
Bongsoo Baik 1 , Sulki Park 1 , Soyoung Ji 1 , Sunyoung Kim 2 and anterior neck. It was difficult to measure its length because of the zig-zag shape involving the skin. The superior margin of the lesion involved the lowest part of the earlobe and the retroauricular area and was 5 cm in dimension. The central ulcerated wound was partly adherent with the underlying soft tissue. A punch biopsy of the nodule showed BCC. A computed tomography scan of the neck showed a subcutaneous mass measuring 5 cm in diameter in the anterio-posterior plane with central skin ulceration. The lesion was suspected of having invaded the sternocleidomastoid (SCM) muscle and the inferior pole of the parotid gland (Fig. 1).
The incision was marked with a safety margin of 5 mm from the visible tumor on the inferior, posterior, and superior portions of the lesion, and a 10 mm safety margin on the mandibular margin and anterior neck (Fig. 2). The anterior incision was deep and included the superficial musculoaponeurotic system on the posterior portion of the mandibular ramus and the platysma muscle on the anterior neck. Other incisions were made deep into the fascia. When the tissue including the tumor was elevated from the underlying tissue, the tumor was found to have invaded the superficial lobe of the parotid gland. Consequently, partial parotidectomy was performed without injuring    The excised specimens were sent to the Pathology department for frozen sectioning. The frozen diagnosis was "Focally suspicious positive basal resection margin. " The final pathologic findings showed BCC, nodular pattern mixed with occasionally micronodular and infiltrating patterns (Fig. 3A), 6.8 × 6.7cm in dimension, invading to the subcutaneous tissue, skeletal muscle and focal salivary gland (Fig. 3B), 1.3 cm in depth. The tumor showed perineural invasion (Fig. 3C), but no lymphovascular invasion. No metastasis on the regional lymph nodes is noted. The resection margins revealed focally tumor involvement on the basal margin, but clear side resection margins.
After further excision of the affected soft tissue, a horizontal local skin flap with a 7-cm pedicle base and 15-cm flap length was elevated to include the skin of the lower posterior portion of the wound. The skin flap was transferred to cover the lateral cheek, the anterolateral neck including the SCM muscle, and the retroauricular area. The remaining open wound was covered with a split-thickness skin graft. The transferred flap and the skin graft healed well without complications (Fig. 4).

DISCUSSION
The four goals of carcinoma treatment include complete tumor excision, prevention of recurrence, preservation of function, and optimal cosmesis. The TNM classification based on the American Joint Committee on Cancer, has been widely used to plan treatment and estimate patient prognosis. According to the modified 8th edition, T categories are based on independent risk factors for poor prognosis [10]. The present case was at the T3 stage with deep invasion ( > 4 cm in diameter and invasion beyond subcutaneous fat).
Treatment of GBCC is not significantly different from that of BCC. Surgical excision is a basic and important approach with an average success rate of 90% to 91% for skin cancer [11]. Although BCC treatment is relatively simple and has a very low mortality rate [12], GBCC requires extensive resection and reconstruction. However, the deep and invasive nature of GBCC accompanied by rapid growth with a high risk of metastasis, makes it difficult to manage. In particular, GBCC involving the head and neck region, with its many important stuctures including nerves, glands, and muscle, is a surgical challenge. This patient' s GBCC was associated with a risk of incomplete excision due to its large size and widespread invasion of extradermal structures. In addition, removal of tumors of this sort can lead to large soft tissue defects, which can render reconstruction difficult. Accordingly, our goal was to eliminate the risk of functional challenges and cosmetic concerns after surgery.
Despite the potential for incomplete resection and difficult wound reconstruction, the tumor was removed with the invaded fascia, as well as some part of the SCM, and a portion of the salivary gland. However, pathology results showed focal invasion to the skeletal muscle and superficial parotid gland as well. After further resection of the SCM muscle and superficial lobe of the parotid gland, a long and wide local flap was transferred to the lateral cheek and post-auricular area. The insufficiently covered wound on the posterior neck was further treated to obtain complete coverage with split-thickness skin graft. The wounds healed successfully without infection, hematoma, facial nerve palsy, or flap necrosis.
Unlike BCCs, GBCCs are more likely to have an aggressive histologic subtype (morpheaform, micronodular), and therefore complete resections are challenging.
Reconstruction options and postoperative cosmetic aspects must also be considered. Nevertheless, it is important to remove the tumor completely and reduce the risk of recurrence. The appropriate reconstruction method should be selected based on primary wound healing, protection of critical structures, contour restoration, and functional and aesthetic outcomes. A number of reconstruction methods are available to deal with large and complex defects. Local flaps and/or skin grafts are straightforward and effective procedures. When a local flap is not feasible, use of a free flap with microvascular surgery will be next choice.