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Embryology and transplantation immunology: a synthesis in sex differentiation.

The mechanism of sex determination has been a scientific concern surely as old as the origin of embryology. It is interesting, therefore, that studies of the H-Y antigen should result in a major integration of the related fields, sex differentiation and the general dynamics of embryology. Progress in this direction became possible once molecular biology had determined that the genetic material was DNA and that cellular activity encoded therein was decoded via transcription of the message into messenger RNA and translation via interaction of transfer RNA and ribosomes. Embryology was dramatically changed. It has become understood that ontogeny must involve a programmatic reading of genetic sequences. What has been one of the concerns of embryologists recently is this question: how is information crucial for each developmental step distributed among cells? Clearly, there are several possibilities: A molecule may be exchanged freely among cells and, therefore, may or may not require