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INCORPORATION OF ANALOG PURINE NUCLEOSIDES INTO THE FORMED ELEMENTS OF HUMAN BLOOD: ERYTHROCYTES, PLATELETS, AND LYMPHOCYTES *

Analogs of purine and pyrimidine nucleosides have received considerable attention in many laboratories concerned with the development of chemotherapeutic agents for malignancies, viruses, and tropical parasites. In addition, a number of these compounds have shown important immunosuppressive activity or have proved of use for the treatment of diseases such as psoriasis. For the past few years, this laboratory has been interested in the interaction of natural or analog purine nucleosides with the formed elements of human blood, i.e., erythrocytes, platelets and lymphocytes. Although these studies were designed originally to analyze the pathways of purine nucleoside metabolism in these cells, a number of unexpected observations have been made that have not only broadened our understanding of normal cellular functions but that also suggest possible useful applications. This report summarizes a number of investigations that have been published earlier or that will be published in greater detail in the future.