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Hepatic tolerance study of hydro-alcoholic extract of Terminalia mantaly H. Perrier (Combretaceae) in rats

Objective: The effect of the hydro-alcoholic extract of Terminalia mantaly H. Perrier (Combretaceae) was evaluated on liver tissue and biochemical markers in Rats were analyzed. Methods: The animals were divided into four groups of 10 animals each (5 males and 5 females). Group1 received 1 mL/100g body weight of distilled water and served as control. Groups 2, 3 and 4 received extract doses of 150,300 and 600 mg/kg body weight, respectively. Blood sampling was carried out to evaluate various biochemical parameters. Results: Biochemical analyzes showed significant reductions in ALT, AST, total and conjugated bilirubin, glucose, total protein, TG, total cholesterol in the treated rats depending on changes in time. On the other hand, this study showed a significant elevation of serum ALP in treated rats with doses of 300 and 600 mg / kg compared to controls and a significant increase of GGT in treated rats with doses of 150 and 600 mg / kg during the third and fourth week. Histopathological study revealed no significant damage in rats liver tissues in groups treated with the hydro alcoholic extract of Terminalia mantaly when compared with the control groups. Conclusion: These results revealed that the hydro-alcoholic extract of Terminalia mantaly, when used in the dose range evaluated in this study, may be well tolerated by the liver.