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Salate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in mice

Significance Multiple sclerosis (MS) is an autoimmune disease that is difficult to manage and for which there is no cure. We have discovered that certain specific sunblock preparations can prevent the development of experimental autoimmune encephalomyelitis (EAE), a widely used animal model of MS. Salate esters in the sunblock preparations were found to be responsible for preventing EAE. Continued exploration of this finding may lead to new approaches to the management of symptoms of MS. UV light suppresses experimental autoimmune encephalomyelitis (EAE), a widely used animal model of MS, in mice and may be responsible for the decreased incidence of MS in equatorial regions. To test this concept further, we applied commercially available sunblock preparations to mice before exposing them to UV radiation. Surprisingly, some of the sunblock preparations blocked EAE without UV radiation. Furthermore, various sunblock preparations had variable ability to suppress EAE. By examining the components of the most effective agents, we identified homosalate and octisalate as the components responsible for suppressing EAE. Thus, salates may be useful in stopping the progression of MS, and may provide new insight into mechanisms of controlling autoimmune disease.