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The Jeremiah Metzger lecture: new additions to the toolbox for global malaria eradication.

Can malaria be eradicated? Yes, but probably not in my lifetime, and not without a highly efficacious malaria vaccine that can be used in conjunction with a set of tools to interrupt malaria transmission at multiple vulnerable points in the parasite-vector-host cycle. Drug resistance remains the single greatest threat to malaria elimination efforts today, and the ability of malaria parasites to evolve resistance to vaccines should be anticipated and mitigated early in the vaccine development process (34). In the meantime, eradication is the right aspirational goal. Malaria elimination is sure to be achieved in many countries, and many, many lives will be saved, if momentum toward eradication can be sustained. The eventual success of a new global malaria eradication campaign will require research as an integral component to keep up with the wily malaria parasite's proven ability to outsmart our best tools.