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Tyrosine Kinase transactivation of renal vascular adrenergic vasoconstriction

EGFR related Tyrosine Kinase (TyrK) is known to transactivate and optimize GTP binding (G) protein mediated renal vasoconstriction in rats. The present study addresses the gender specificity of TyrK receptor mediated activity in α‐adrenergic receptor (α‐adrR) stimulation of intrarenal blood vessels. Male and female rats have similar Gene Chip Array expressions of α 1B–and α 1D‐ α‐adrR, but Gene Chip Array expression of α 1A/C‐ adrR and the Bmax for prazosin binding is greater in females. Renal interlobar artery constriction to phenylephrine (PE; α 1B, D and A/C agonist) is markedly attenuated in vessels obtained from male rats, and pretreated with Lavendustin A (L) while constriction to A61603 (α 1A/C agonist is unaffected by L. Vessels from female rats treated with L demonstrate only minor attenuation with either agonist. Gene Chip Array expression of Growth hormone receptors is lesser while Receptor Type A, Tyrosine Phosphatase and Gaq G protein expression is greater in female intrarenal arteries. Transactivation by TyrK is a greater factor in α‐adrR mediated vasoconstriction in male than in female Wistar rats.