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Erythropoietin-induced stimulation of heme synthesis by dimethylsulfoxide-treated Friend leukemic cells in vitro.

Abstract Friend leukemia cells grow in suspension culture as undifferentiated blasts which do not respond to erythropoietin. An investigation was undertaken to determine if these erythroleukemic cells could be induced to respond to erythropoietin. The rate of heme synthesis was measured in Friend leukemia cells which were first exposed to dimethylsulfoxide and then to erythropoietin. These studies demonstrated that culture for 48 hours in the presence of dimethylsulfoxide renders these cells responsive to erythropoietin as manifested by increased heme synthesis. Erythropoietin did not increase the proportion of benzidine-positive cells in the culture suggesting that the erythropoietin-responsive cells were those cells which had already begun to differentiate prior to exposure to erythropoietin. Hence, these erythroleukemic cells are capable of responding to erythropoietin, the physiologic regulator of erythropoiesis.