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Experimental tests of proton beam localization.

The depth of penetration of heavy charged-particle therapy beams is sensitive to the density of tissues traversed. Maximum depth of dose contours will vary appreciably as the beam passes through bone, muscle, lung, and air or gas. Calculations suggest that beam activation of the short-lived positron-emitting isotope 15O in vivo will permit localization of proton therapy beams with resonable detected-event density and dose. Preliminary tests of this method indicate that the beam can be located at depth with a typical dose of 15 rad, using a large field-of-view positron camera on-ling. This technique is also applicable to other heavy charged-particle beams, negative pions, and heavy ions.