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Renin release in chronic paraplegia.

Summary: Plasma renin levels were measured before and after upright tilting at 45o for 30 minutes in twelve chronic paraplegic patients and four normal subjects. The paraplegics did not show orthostatic hypotension and developed a tachycardia in response to tilting. Individual plasma renin responses were variable in both groups but plasma renin activity increased significantly in the paraplegics. The data shows that despite complete motor and sensory interruption, postural cardiovascular and renal autonomic reflexes are intact in these patients.