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A reduced sampling protocol for the identification of insulin sensitivity

Recent prospective studies have demonstrated that low insulin sensitivity is highly predictive for the eventual development of non-insulin dependent diabetes mellitus (NIDDM). In this paper, the authors propose an new 13-sample protocol for the efficient estimation of insulin sensitivity in normal subjects and NIDDM patients. Compared to other reduced sampling protocols, the new protocol estimates insulin sensitivity and glucose effectiveness with better correlation and lower bias.