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Preterm delivery as a predictor of diurnal cortisol profiles in adulthood: Evidence from Cebu, Philippines

Fetal exposure to elevated maternal cortisol can permanently modify hypothalamic–pituitary–adrenal (HPA) axis function, and thereby have long‐term health impacts. Maternal cortisol steadily increases throughout normal pregnancy, but is abnormally high in preterm deliveries (<37 weeks). Prematurity remains a widespread public health problem, yet little is known about its potential long‐term effects on adult HPA function. Here we test the hypothesis that diurnal cortisol profiles measured in young adulthood will vary based upon an individual's preterm status.