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Spontaneous thyroiditis in the obese strain of chickens. IV. The effect of thymectomy and thymo-bursectomy on the development of the disease.


 By means of radioimmunoelectrophoresis and radioelectrophoresis, thyroxinebinding antibodies were demonstrated on one or several occasions in about 16% of obese strain (OS) chickens, but not in normal White Leghorn chickens. Thyroxine antibodies were generally demonstrated at a later time than hemagglutinating thyroglobulin antibodies. By means of absorption experiments, evidence was obtained that thyroxine is present as an antigenic determinant on the chicken thyroglobulin molecule. Thyroxine-binding antibodies occurred in greater frequency in sera with higher hemagglutinating antibody titers. Thyroxine-binding antibodies were present in 22% of chickens with moderate thyroid infiltration and residues of functioning thyroid tissue but only in 9% of chickens with total or almost total destruction of the thyroid tissue. Intravenous injection of OS sera with thyroxine-binding antibodies into normal chicken embryos caused an increase of the mean thyroid follicle diameter. This was explained as due to hypophyseal feedback after binding and inactivation of the thyroxine.