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Reduced Sodium Concentration and Increased Sodium‐Potassium Pump Activity of Erythrocytes in Human Hypertension

Erythrocyte Na, Na/K, and ouabain-sensitive and ouabain-insensitive 86Rb uptake (K transport) were measured in whole blood of 16 normotensive and 19 hypertensive white male subjects, within seconds or minutes after withdrawal of blood. Erythrocyte Na, and Na/K, were reduced (p < 0.05), and ouabain-sensitive 86Rb uptake was increased (p < 0.01) in hypertensive subjects. In a separate group of hypertensive white male subjects, an inverse correlation was found between erythrocyte Na/Ki and ouabain-binding sites per erythrocyte (r = 0.85, p < 0.01, n = 9). The abnormalities of erythrocyte cation fluxes in hypertensive subjects are similar to those induced by aldosterone in vascular smooth muscle cells and by glucocorticoid administration in the erythrocytes of human subjects, suggesting similarities in pathogenesis.