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[Correlation between symptoms and diagnosis in pharmacotherapeutic decision process].

Evaluation of influence of psychopathological symptoms (AMDP System) and diagnosis (ICD-9) on the choice of drug therapy (neuroleptics or antidepressants) for psychiatric in-patients was the aim of this work. Statistical analysis of 3745 patients led to three different decision-making procedures. These procedures are based on symptoms or diagnoses alone or on both symptoms and diagnosis. CART-Analysis was used for statistical analysis. Reclassification errors for neuroleptics were always larger than reclassification errors for antidepressants. The results show that both symptoms (error neuroleptics 20.2%, respectively antidepressants 15.0%) and diagnosis (20.8%, resp. 11.9%) alone are not sufficient to explain the choice of drug therapy. Lowest error rates were gained in a hierarchical model for the choice of drug treatment where both diagnosis and symptoms were used (17.1%, resp. 10.1%).