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Specific IgE and IgG to gelatin in children with systemic cutaneous reactions to Japanese encephalitis vaccines

Background: Systemic allergic reactions to Japanese encephalitis (JE) vaccine that include urticaria, angioedema, and rash have been reported. In Japan, children who suffered from allergic immediate‐type reactions to JE vaccine had antigelatin IgE in their sera. However, the immunologic mechanism of allergic nonimmediate‐type reactions that consist of cutaneous signs appearing several hours or more after JE vaccination has not been defined.