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Defect of NADH dehydrogenase in Leigh syndrome

Recently, we reported a patient with Leigh syndrome in this journal (1). Biochemical studies gave indirect evidence of a NADH dehydrogenase deficiency. In skeletal muscle 600 x g supernatant of this patient, stored at -7O"C, we measured activities of NADH:O, oxidoreductase and NADH:Q, oxidoreductase as described by Fischer et a1 (2). The NADH:O, oxidoreductase activity was determined in the presence of cytochrome c. The rotenone-sensitive NADH oxidation by both enzyme systems was determined at 340 nm (2). NADH:O, oxidoreductase activity was 2.1 nmol NADH oxidized/min/mg protein (control range 4.522.9, n = 7 ) and NADH:Q, oxidoreductase activity was 3.8 nmol NADH oxidized/min/mg protein (control range 10.6-22.1, n = 7). NADH oxidoreductase