{'fraction_non_alphanumeric': 0.023454157782515993, 'fraction_numerical': 0.005330490405117271, 'mean_word_length': 5.804347826086956, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Recombinant human bone morphogenetic protein-2 loaded porous β-tricalcium phosphate microsphere-hyaluronic acid composites promoted osseointegration around titanium implants

ABSTRACT We fabricated two β-tricalcium phosphates (β-TCP) microsphere-hyaluronic acid composites and evaluate their efficacy as recombinant human bone morphogenetic protein-2 (rhBMP-2) carriers when combined with titanium implants in rabbit tibial diaphysis. After 4 weeks, the new bone formation was observed with plain radiographs and histology and was analyzed via micro-CT. Micro-CT analyses results showed the composites with hydrogel and BMP had a significantly higher bone to implant contact ratios and new bone formation than the other groups did. Our results indicated that rhBMP-2 loaded β-TCP/hydrogel composites could significantly elevate osteogenesis and osseointegration of the titanium implants in rabbit tibia medullary space. GRAPHICAL ABSTRACT