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Clinical Experience in the Treatment of Pneumonia with Cefuroxime

Patients and Methods One patient with acute bronchitis, 2 with acute exacerbation of chronic bronchitis and 32 with pneumonia acquired outside the hospital were treated with cefuroxime. Twenty-eight were men and 7 women. The age of the patients ranged from 18-76 years and the average was 53. Sixteen patients were over 60. The diagnosis of pneumonia was based on rcentgenological findings of pulmonary infiltration and the diagnosis of bronchitis on typical physical findings in a febrile patient. Several patients had concurrent diseases and those occurring most frequently are listed in Table 1. No patient had a history of penicillin hypersensitivity. Cefuroxime was given in doses of 1.0 g i.m. 3 times daily. The length of the course was 7-12 days and the mean duration of treatment was 9.7 days. One patient had 2 courses. Thirty patients had received no treatment with antibiotics before the administration of cefuroxime was started. Three patients had received a few doses of oral tetracycline and 2 patients oral penicillin. One of these had also had oral erythromycin prior to admission. Cefuroxime was substituted because no response was seen or because of relapse. Laboratory data were obtained before and after treatment. These included hamoglobin and white blood count, erythrocyte sedimentation rate, creatinine and blood urea measurements, liver function tests and urine analysis. Blood cultures