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Nonisotopic Probing, Blotting, and Sequencing

abnormalities of the branchial arch in 45, XO fetuses. There is a final sixth section on the epidemiology of congenital malformation. Overall the illustrations are relevant and well produced. The chapters are well referenced and indexed. Such a collection of papers as well as overview chapters is an extremely extensive and useful source for those with an interest in the developmental mechanisms of heart disease but does tend to lead to repetition, unlike a textbook. As an illustration there are several overlapping papers dealing with deletion of chromosome 22ql and similarly heterotaxy and the inv/ inv mutation in the mouse. The quality of the papers is variable but overall the editors' initial aim is achieved with the book providing an interesting review of current understanding of some of the mechanisms in developmental heart disease. It would be a welcome addition to the library of any department with an interest in cardiac genetics.