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Mapping chromatin accessibility in mouse nephron segments

Active DNA regulatory elements recruit transcription machinery to drive gene expression and generate nephron heterogeneity, which is crucial for renal physiology and pathophysiology. Such heterogeneity poses a significant challenge in the precise mapping of these DNA regulatory elements in each renal segment. Whole kidney chromatin accessibility analysis averages the signal from multiple cell types, thus it is necessary to carry out such analysis at the single‐tubule level.