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PP.15.33: ORTHOSTATIC HYPOTENSION AND HYPERTENSION IN A POPULATIONAL SURVEY

Objective: Orthostatic hypertension is considered as a marker of unfavorable outcome in patients with diabetes and/or senility. Prevalence of the orthostatic hypertension was investigated predominantly in patients with essential hypertension, while orthostatic blood pressure (orthoBP) reaction was rarely investigated in general population. The aim of our study was to investigate the prevalence and risk factors associations of the orthoBP in a random sample of Russian population. Design and method: 800 apparently healthy participants aged 25–65 years were randomly selected from Saint-Petersburg inhabitants (a sample form ESSE-RF study). All participants signed informed consent and filled in the questionnaire regarding risk factors, concomitant diseases and therapy. Fasting lipids, glucose (Abbott Architect 8000 (USA)) were performed. BP was measured in sitting position (after 10 minutes of rest) and after 3 minutes in standing position with calculation of delta SBP. Orthostatic hypotension was defined as delta SBP < -20 mm Hg and orthostatic hypertension as > 10 mm Hg. Multiple logistic regression was performed. Results: Table 1. Prevalence and odds ratio for kinetics of orthoBP.* Figure. No caption available. *- presented only significant results with p <0,05 Conclusions: In general population of SPb inhabitants orthostatic hypertension was detected significantly more often compared to orthostatic hypotension despite the same risk factors. Presence of essential hypertension and antihypertensive medication was associated with orthostatic hypotension rather than hypertension.