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Studies on the function of cell membrane. 4. Electron microscopic observations on changes in ultra-structure of liver cell membranes in CCl4-treated rats.

Abstract Morphological changes of liver cell membranes in CCl4-administered rats were observed electronmicroscopically by using mainly a negative staining method. CCl4 caused not only disappearance of elementary particles attached to the surface of cell membranes, but also that of hexagonal subunit patterns (treated with 1 % DOC) in the membranes of tight junction 3–6 hr after administration. Present data indicates that CCl4 primarily affects the plasma membrane rather than endoplasmic reticulum.