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Modeling the ischemic neurovascular unit in a dish using patient‐specific induced pluripotent stem cells

The blood‐brain barrier (BBB) is a component of the neurovascular unit formed by specialized brain microvascular endothelial cells (BMECs), astrocytes and neurons. It plays an important function in the maintenance of brain homeostasis by tightly regulating the entrance of water and solutes into the brain and by blocking the entrance of potentially neurotoxic molecules. Dysfunction of the BBB is a key element observed in various neurological disorders and, in particular, following stroke injury.