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[Vitamin D deficiency in psoriatic patients in north-east of Poland].

Background
Recent studies point
out the important role of vitamin D
in the pathogenesis of many autoimmune
diseases, in between psoriasis.
Vitamin D regulates function
of the dendritic cells, proliferation
and maturation of the keratynocytes
and lymphocytes T. The aim of the
study was to evaluate serum vitamin
D (25OHD) concentrations in psoriatic
patients in the north-east of Poland
and their comparison in the summer
and winter period of the year. We also
evaluated relationship between 25OHD
concentration and disease severity,
prevalence of psoriatic comorbidities
and laboratory results.


Material and Methods
25OHD
serum concentration was evaluated
by electrochemiluminescent method
in 115 patients with exacerbated
plaque type psoriasis. 39 patients were
evaluated in the summer and 79 in the
winter time. 28 patients from winter
group were treated with narrow band
ultraviolet B radiation (NB-UVB). The
results were compared with 38 healthy
persons.


Results
25OHD serum concentrations
of psoriatic patients were
significantly lower than in the control
group (p=0,0003). Vitamin D deficiency
was diagnosed in 66% of patients in
the summer time and in 63% in winter
time; in the control group: 24% during
the summer and 71% during the winter.
After UVB phototherapy we observed
reduction of skin lesions, measured
as a significant decline in the Psoriasis
Area and Severity Index (PASI)
(p<0.001). The serum 25OHD concentration
increased (p<0.001). After the
treatment 65% of the psoriatic patients
reached normal range of 25OHD concentration,
35% of patients were still
vitamin D insufficient. We demonstrate
positive correlation between increase
in 25OHD and number of NB-UVB phototherapy
sessions (r=0.38).


Conclusions
We have observed vitamin
D deficiency both in psoriatic patients
and in the control group. Among
psoriatic patients the praevalence of
deficiency were higher than in the
control group, especially during the
summer months. Frequent vitamin D
defficiency in the groups studied indicates
the need of for its supplementation. The 25OHD serum
concentrations increased after phototherapy with UVB.