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Trend of clinical diagnosis of hepatitis B virus: quantity and standardization

Antiviral treatment of chronic hepatitis B is aimed at HBeAg seroconversion and inhibition of HBV viral replication. A lot of evidences showed that quantification of hepatitis B vires play an important role in timing selection of treatment initiation, treatment failure evaluation, and screening of resistance. International units per ml (IU/ml) are used to express results for HBV DNA quantification by WHO. HBsAg and HBeAg are potentially useful to predict HBeAg seroconversion. This review discusses the prospective application of detection of HBV virological and serological markers, and their use in clinic. 
 
Key words: 
Hepatitis B virus;  Hepatitis B surface antigen;  Hepatitis B e antigen;  Biological markers