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Effect of elevating tissue ammonia concentration on renal function in dogs.

SUMMARY 
 
Experiments have been carried out to test the hypothesis that renal damage caused by ischsemia is due to the intrarenal build-up of ammonia. 
 
 
 
It has been shown that the ammonia concentration in dog kidneys after prolonged ischcemia is approximately 4 micromoles/gram of kidney. 
 
 
 
Renal function studies (creatinine clearance, TmPAH, osmolar clearance, renal plasma flow) have been carried out on 6 unilaterally nephrectomised dogs before, during and after the concentration of ammonia in renal tissue had been artificially raised by an infusion of ammonia into the renal artery. 
 
 
 
In one dog ammonia injections sufficient to raise the blood ammonia to 1,000 micrograms/100 ml. caused circulatory collapse and death. A second dog, with elevation of tissue ammonia to 12 micromoles per gram of kidney, showed a temporary reduction in renal function which returned to normal when the injection was discontinued. In the other animals, an ammonia infusion which raised tissue ammonia to 3.4–7.1 micromoles per gram had little effect on renal function. 
 
 
 
It seems unlikely that the ammonia produced by the ischemic kidney contributes significantly to ischsemic renal damage.