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Determination of protein location diversity via analysis of immunohistochemical images from the Human Protein Atlas

The Human Protein Atlas (HPA) is a repository of location patterns of about 11000 proteins within tissues and cell lines. In this work we summarize some of our current work on analyzing immunohistochemical images of proteins within 7 distinct tissues. Firstly, we present our efforts to analyze spatial point patterns of protein staining and determine protein subcellular location from image-derived proximity features. Next, we present a method to identify proteins that have differential location between normal and cancer tissue. These methods provide a principled way to characterize location diversity of the proteome across normal and cancer tissues.