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Blockade of adrenergic transmission by dehydroemetine

dopamine concentration slowed down the conversion of tyrosine to dopa by a feedback mechanism resulting in a subsequent decrease in the concentrations of both noradrenaline and dopamine. When dopamine approached or reached the control level, the feedback effect of noradrenaline became dominant which by increasing the conversion of tyrosine to dopa restored a new balance on the one hand between catecholamines and tyrosine, and on the other hand between noradrenaline and dopamine. Since the deflection in tyrosine concentration after CS, was not so extensive as after DDC, and at least after the first or second exposures the increase in dopamine corresponded to the decrease in noradrenaline, CS, seems to be more suitable than DDC as an agent for the study of dopamine receptors.