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The Effects of Exposure Time on Systemic Inflammation in Subjects with Exposure to Zinc- and Copper-Containing Brazing Fumes.

INTRODUCTION
Inhalation of copper and zinc containing brazing fumes (2.5 mg m for 6 hours) is able to induce asymptomatic systemic inflammation which is supposed to be connected with an increased risk for cardiovascular disease. In this study it was investigated if inflammation can be prevented by reducing the exposure time.


METHODS
15 healthy male subjects were exposed to such brazing fumes in a cross-over design for 3, 4, and 5 hours in randomized order. Before and 24 hours after exposure, blood samples were taken and CRP as marker for an acute phase reaction was measured.


RESULTS
Five hour exposure induced an increase of CRP, whereas the shorter exposure times did not result in a significant inflammatory reaction.


CONCLUSIONS
Reducing daily exposure times below 5 hours is able to prevent systemic inflammatory reactions.