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The Influence of Lactational Intensity and Exogenous Prolactin on Serum Thyroxine Levels in the Rat

Summary Rat serum T4 levels were inversely correlated with lactational intensity, and the markedly reduced serum T4 observed in high-lactating rats could not be counteracted with 10 times the normal dietary iodine. Exogenous ovine prolactin (2 mg/day for 15 days), when administered to nonlactating rats, had no effect on serum T4. It was concluded that high serum prolactin, associated with nursing, was not a factor directly contributing to the reduction of serum T4 observed during lactation.