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Dihydropteridine-reductase activity in breast cancer. Preliminary report.

The dihydropteridine-reductase activity was measured in 206 breast cancers. Large variations were found: 6% of tumors showing high values closed to those noted in liver, whereas the main group has activities of same magnitude of that in cultured fibroblasts. Significant correlation appeared between dihydropteridine-reductase activities and hormonal dependence, as measured by cytosolic estrogen receptor sites.