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Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation

Partial nerve injury results in chronic pain that is difficult to treat effectively. To investigate the anatomic basis of this phenomenon we used wheat germ agglutinin–horseradish peroxidase (WGA‐HRP) to label the central projections of uninjured small fibers (Aδ and C) in a well‐established model of neuropathic pain created by selective spinal nerve ligation in the adult. We found extensive sprouting of uninjured WGA‐HRP‐labeled afferents into the central termination field in lamina II of dorsal horn normally occupied by L5 afferents whose peripheral axons had been ligated distal to the dorsal root ganglion. The formation of new projections by uninjured fibers into a functionally but not anatomically deafferented field in the adult may play a role in the development of chronic pain.