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Investigating the Kinetic Effects of the Allosteric Interaction Between Newly‐Discovered Dynamic Hydrogen‐Bonded Residues and the HINT1 Active Site

Histidine Triad Nucleotide binding proteins (HINTs) are an ancient class of enzyme notable for their acyl‐AMP hydrolase and phosphoramidase activity. This class of protein is of research significance due to its involvement in antiviral prodrug activation, as well as its natural role in opioid tolerance. Previously, the Wagner Lab has published the substrate specificity profile, full kinetic mechanism, and kinetics assay for the HINT isozyme HINT1. However, the active site dynamics of this enzyme have yet to be elucidated.