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OP10.05: Relationship between fetal crown‐rump length and volume from 11 + 0 to 13 + 6 weeks of gestation by 3D XI VOCAL ultrasonography

Objective: To define normal ranges and equation for gestational sac at 11–14 weeks based on a simple measurement. To study the relationship between gestational sac measurement and birthweight and height. Material and methods: This study was conducted prospectively in a large screening center. Gestational sac measurement was performed transvaginally at 11–14 weeks of gestation. It was defined on a strict sagittal plane of the uterus as the maximum distance between the two extreme ends of the sac. We used a regression approach to compute reference charts and equations for first gestational sac measurement. The relationship between gestational sac Z score and birthweight and height, expressed as Z scores, was evaluated. Results: Data were collected in 1324 pregnancies. Gestational sac measurement across gestational age (GA) at first trimester were best described by a linear equation (p<0.05). There was a significant correlation between gestational sac measurement and birthweight and height (p=0.01). Gestational sac Z score at first trimester was also correlated with maternal body mass index. However, the relationship between birth weight and height remained significant after adjustment on maternal BMI (p=0.03). Conclusion: First trimester gestational sac measurement are correlated with birthweight and height. This could reflect the early expression of fetal growth potential and be partly associated with maternal body mass index, which is already known to impact on prenatal growth.