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Induction of Hepatomas in Hamsters by an Avian Adenovirus (CELO)

Summary Hepatomas were induced in approximately 4% of inbred LSH/LAK hamsters inoculated subcutaneously with CELO virus. The sera from these animals stained the CELO T antigen found in lytically infected chick kidney cells. The tumors contained hamster types A and C virus particles. The relationship between these indigenous hamster viruses and tumor induction by CELO virus is being investigated.