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Role of Sarco/Endoplasmic Reticulum Calcium ATPase in Lower Urinary Tract Smooth Muscles

The control of intracellular Ca (2+) is central to the regulation of smooth muscle contractility. A defect in sarco/endoplasmic reticulum calcium ATPase (SERCA) activity and its expression level has been suggested as a major pathology in cardiac dysfunction. Recent studies have demonstrated that the increased expression of SERCA2a improves myocardial contractility and Ca (2+) handling in disease conditions. The therapeutic transfer of SERCA has been tried in an animal heart failure model with promising results.