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CHRONIC MUCOCUTANEOUS CANDIDIASIS WITH ABNORMAL FUNCTION OF SERUM COMPLEMENT

Three members of a family suffering from chronic mucocutaneous candidiasis were investigated and found to have decreased activity of total serum complement. One other member of the family had normal activity of total serum complement and did not have chronic infection with Candida albicans. No other consistent abnormality was found in the three affected patients, and it is suggested that deficient activity of serum complement may be related to the undue susceptibility of these patients to infection with Candida albicans.