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A Screening for the Antiviral Effect of Extracts from Brazilian Marine Algae against Acyclovir Resistant Herpes Simplex Virus Type 1

Abstract In order to verify the antiviral activity of extracts from Brazilian marine algae, aqueous cold extracts of eight species belonging to the classes Phaeophyceae, Rhodophyceae and Chlorophyceae were assayed for anti-herpes simplex virus (HSV-1) activity using an acyclovir-resistant strain. All extracts inhibited the propagation of HSV-1 in HEp-2 cells at non-toxic concentrations with Laminaria abyssalis the most potent species. These results suggest the Brazilian algae are promising sources of natural antiviral agents for the treatment of acyclovir resistant HSV-1 infections.