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Leptin Receptor Signaling is Required for Vaccine‐Induced Protection Against Helicobacter pylori

Background:  A vaccine against Helicobacter pylori would be a desirable alternative to antibiotic therapy. Vaccination has been shown to be effective in animal models but the mechanism of protection is poorly understood. Previous studies investigating the gene expression in stomachs of vaccinated mice showed changes in adipokine expression correlated to a protective response. In this study, we investigate a well‐characterized adipokine‐leptin, and reveal an important role for leptin receptor signaling in vaccine‐induced protection.