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Distribution of tritium-labelled 8-methoxypsoralen in the rat, studied by whole body autoradiography.

The distribution of 3H-8-methoxypsoralen has been studied in rats by whole body autoradiography. The highest organ concentration were seen 1 hour after dosing. The most pronounced accumulation was found centriblobular in the liver, corticomedullary in the kidneys, and in the cortex of the adrenals. The concentrations in these organs were approximately six times higher than in the blood. Other organs showed concentrations similar to blood levels. Illumination with UVA (10 J/cm2) increased the concentrations in the subcutis.