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Evaluation of the quantitative Rappaport rapid plate test in the diagnosis and treatment of syphilis.

A comparison of the in vitro activity of rosamicin, erythromycin, penicillin and tetracycline against N. gonorrhoeae, P-lactamase This paper examines the in-vitro activity of rosamicin, erythromycin, spiramycin, penicillin, and tetracycline against 517 non- penicillinase-producing strains, and 13 penicillinase-producing strains of N. gonorrhoeae. Susceptibility testing was carried out using a standard agar plate dilution method. At a level of 01 AMg/ml rosamicin inhibited 90-9% of the non- penicillinase-producing strains while a range of 25-7% to 56-3% was obtained with the other antibiotics with the exception of spiramycin. Spiramycin was the least active, even at a level of 4 Mg/ml; only 66 3% of these isolates were inhibited. Rosamicin inhibited 46- 2% of the penicil-linase-producers at 0 1 lAg/ml, compared with 30 8%7o with erythromycin. These results indicate that rosamicin may prove useful in the therapy of gonorrhoea due to both non-penicillinase-producing and penicillinase-producing strains of N. gonorrhoeae, indicating a need for clinical studies.