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Frontomaxillary facial angle in screening for trisomy 21 at 11 + 0 to 13 + 6 weeks

Trisomy 21 is associated with a flat face, which can now be quantified by measurement of the frontomaxillary facial (FMF) angle. The aim of this study was to examine whether in trisomy 21 fetuses fetal nuchal translucency (NT) thickness and maternal serum free ß‐human chorionic gonadotropin (ß‐hCG) and pregnancy‐associated plasma protein‐A (PAPP‐A) are independent of the FMF angle, and to estimate the performance of a first‐trimester screening test for trisomy 21 that includes measurement of the FMF angle.