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The effect of leukotrienes C4 and D4 on microcirculatory flow in humans

By quantifying the flare response, leukotrienes LTC4 and LTD4 were shown to increase the microcirculatory flow in a sigmoidal dose‐response relation over the dose‐range of 6‐25‐800 pmol. LTD4 was found to be more potent than LTC4 after 5 min, but not after 15 min, as estimated by this method. Laser‐Doppler flowmeter studies confirmed that LTD4 is a more potent vasodilator than LTC4.