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Gastric Cancer Prevention by Demethylation

Niwa and colleagues report in this issue that treatment with the DNA demethylation agent 5-aza-2′-deoxycytidine decreases the incidence of gastric cancers in an animal model of Helicobacter pylori–promoted gastric cancer. This provocative study underscores the importance of changes in DNA methylation that contribute to the origin of inflammation-related cancers. The findings also raise the exciting possibility of cancer prevention by altering DNA methylation events early during tumorigenesis. Cancer Prev Res; 6(4); 253–6. ©2013 AACR.