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172 WATER AND HYALURONAN CONTENT IN THE LUNGS IN THE PERINATAL PERIOD – an experimental study in rabbits

Little is known about the role of hyaluronan in perinatal lung water balance. After birth interstitial lung water gradually decreases. Later, an increase may occur due to functional disturbancies or inflammatory processes. The aim of the present study was to elucidate the changes in water and hyaluronan content in the lungs after preterm birth. Lungs were taken for analysis from rabbit pups born one or two days before term at different postnatal ages. In both gestational age groups, water content measured as wet/dry weight quotient decreased during the first day of life from 9/1 to 6-7/1, and then remained at that level during the next four days. In pups born 1 day before term hyaluronan content measured by a radiometric method as ug/g dry weight averaged 206 at birth, increased to a peak of 382 at 3 days of age (p<0.02), and then decreased again. In pups born 2 days before term the hyaluronan content reached a peak at 4 days of age. Conclusion; The immediate postnatal decrease in lung water content in healthy preterm rabbit pups is not accompanied by an over-all decrease in pulmonary hyaluronan.