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A comparitive study on levels of sirt 1 and antioxidant status in type 2 diabetic and diabetic nephropathic patients - A case control study

A comparitive of sirt 1 and antioxidant status in type 2 diabetic and diabetic nephropathic patients Abstract Diabetic nephropathy is a leading cause of end-stage renal failure worldwide. Its morphologicc haracteristics include glomerular hypertrophy, basement membrane thickening, mesangial expansion, tubular atrophy, interstitial fibrosis and arteriolar thickening. All of these are part and parcel of micro vascular complications of diabetes. Previous study evidences indicates that oxidative stress is the common denominator link for the major pathways involved in the development and progression of diabetic microas well as macro vascular complications of diabetes. SIRT1 deacetylates target proteins using the coenzyme NAD+ and is therefore linked to cellular energy metabolism and the redox state through multiple signalling and survival pathways. SIRT1 deficiency under various stress conditions, such as metabolic or oxidative stress or hypoxia, is implicated in the pathophysiologies of agerelated diseases including diabetes, cardio vascular diseases, neurodegenerative disorders and renal diseases.