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[Effects of bFGF on biological characteristics of cells derived from periodontium].

OBJECTIVE
To observe effects of basic fibroblast growth factor on the biological characteristics of cultured human gingival,periodontal ligament fibroblasts and human alveolar bone cells, such as proliferation, alkaline phosphatase activity, protein synthesis and the formation of mineralized nodules.


METHODS
Using cell culture technique, MTT colorimetric assay, ALP activity assay, Commasie brilliant blue staining and Dahl McGec-Russell's alizarin red stain for calcium.


RESULTS
bFGF enhanced the proliferative responses of the three types of cells. In contrast, bFGF inhabited the induction of alkaline phosphatase activity, protein synthesis and the mineralized nodule formation by PDLF and ABC.


CONCLUSION
bFGF can enhance cell proliferation while inhibit cytodifferentiation, thus accelerating periodontal regeneration.