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Raising the head‐of‐bed by 30 degrees reduces ICP and improves CPP without compromising cardiac output in euvolemic patients with traumatic brain injury and subarachnoid haemorrhage: a practice audit

© 2006 Copyright European Society of Anaesthesiology, European Journal of Anaesthesiology 23: 173–180 We found that systemic pretreatment with the NOS inhibitor 7-NI augmented the analgesic effect of tramadol in the hot-plate test even though it did not exhibit an analgesic effect by itself. No effects of pretreatments with 7-NI or L-NAME were observed in acetic acid induced writhing. The potentiation of analgesic effect of tramadol by 7-NI might be an indicator of the involvement of NO in the antinociceptive effect of tramadol. This is a preliminary study which suggests that NOS inhibitors may interfere with the analgesic effect of tramadol for the first time. It is also possible that 7-NI may increase the analgesic effect of tramadol other than the inhibition of neuronal NOS inhibition with some indistinct mechanism. In order to find out the overall aspects of this synergism, further studies are required.