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Effects of Ethanol Induced Gastric Lesions in Sialoadenectomized Rat: An Ultrastructural Study

ABSTRACT In this study, the effects of removal of the submandibular gland in Wistar albino rats has been examined by transmission electron microscope in terms of the effects on the susceptibility of gastric mucosa and mucus to the damaging actions of ethanol. The adult female Wistar albino rats were divided into four groups. The animals served as Control(C), Sialoadenectomy(SX), Ethanol(E) treated and Sialoadenectomy +Ethanol(SX+E) treated groups (n: 7). Mucus level of the gastric mucosal barrier were measured using Corne's spectrofotometric method. The difference of mucus mean levels between the groups was evaluated statistically by Kruskal-Wallis test. A significant difference was found between the groups (p<0.05). The importance of difference among the mucus levels was compared by Dunnet test with multiple comparisons. According to comparisons statistically a significant difference was found between the C-E and SX-E groups (p<0.05). Electron microscopic evaluation indicated that the stomach mucosa epithelium in control group showed a normal appearance while changes were observed in all experimental groups. However, severe basal epithelium of intercellular adhesions was destroyed, apical mucus granule was decreased, and parietal cell of intrasitoplasmic canaliculi-microvillus was increased in sialoadenectomy and ethanol treated groups. These data showed that sialoadenectomy leads to an increase in mucosal inflammation, decrease in mucus level shown electron microscope in animals subjected to sialoadenectomy and ethanol treated.