{'fraction_non_alphanumeric': 0.024657534246575342, 'fraction_numerical': 0.0045662100456621, 'mean_word_length': 4.89247311827957, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Gamma delta T cells in human decidua.

OBJECTIVE
Our purpose was to assess the presence and frequency of gamma delta T cells in the decidua of term and first-trimester pregnancies.


STUDY DESIGN
Term and first-trimester placentas were obtained from normal subjects. Frozen sections and cell suspensions were prepared from decidual tissue and stained with monoclonal antibodies to T cell markers. Cell sorter analysis was performed.


RESULTS
gamma delta T cells in term decidual cell preparations were enriched 2.4-fold compared with peripheral blood. Immunohistochemical staining of term decidual tissue demonstrated many gamma delta + and CD3+ T cells, fewer CD8+ cells, and rare CD4+ cells. In contrast, first-trimester decidua was found to be devoid of gamma delta + T cells, by both cell sorter analysis and immunohistochemical methods.


CONCLUSIONS
Term, but not early, decidua harbors a resident T-cell population that is significantly enriched in gamma delta T cells compared with blood. These lymphocytes may provide an added defense mechanism against infection during the peripartum.