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A population-based study of peroxisome proliferator-activated receptor-gamma gene polymorphism for type 2 diabetes mellitus complicated with cerebral infarction in Chinese Han

Objective To investigate the genetic association between the PPARγ gene polymorphism and type 2 diabetes mellitus complicated with cerebral infarction.Methods 791 people were recruited into this study,and they were divided into three groups:NC(337),T2DM(250) and T2DM with CI(204).SNP rs1875796,a C to T base change located in intron 4 of the gene,was used as a genetic marker.PCR-based restriction fragment length polymorphism analysis was applied to genotype rs 1875796(Hha I site).Results The frequency of allele C was significantly higher in female in T2DM with CI patients than T2DM and NS patients(χ2=6.672,P=0.010,OR=1.991,95%CI 1.176～3.358 and χ2=12.384,P0.0001,OR=2.499,95%CI 1.500～4.162).And the frequency of CC+CT genotype was also significantly higher in female T2DM with CI patients than NC patients(χ2=4.656,P=0.031,OR=2.008,95%CI 1.006～3.782 and χ2=8.462,P=0.004,OR=2.486,95%CI 1.346～4.593).Multiple factor regression analysis showed that the difference was still significant after adjusting the traditional risk factors.The frequency of allele and genotype showed no significance between male T2DM complicated with CI and male T2DM and NC patients.Conclusions The present study suggests that the PPARγ gene be likely to contribute to the etiology of type 2 diabetes mellitus complicated with cerebral infarction in female Chinese Han.