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NEONATAL UNDERNUTRITION AND RNA SYNTHESIS IN DEVELOPING RAT BRAIN 1

—Underfeeding of newborn rats results in a decreased body and brain weight at 10, 20 and 30 days of age. The DNA and RNA content of the brain in these animals are similar to those of normal controls. The in vivo and in vitro synthesis of RNA in brain is significantly decreased in undernourished rats at 10 days of age when compared with controls. The metabolic transformation of 3H‐orotic acid to nucleotides is also diminished. A short period of food rehabilitation produces ‐an improvement in the above mentioned alterations. However, a reduced incorporation of label into microsomal RNA persists even in the last condition. The results suggest that malnutrition, during the first days of life, alters the metabolism of cerebral RNA.