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DNA-transfer approaches in treatment of chronic inflammatory joint disease.

Chronic inflammatory joint diseases (CIJDs), including rheumatoid arthritis, are complex inflammatory processes that result in joint damage, pain, deformity, and disability. Established therapies of pain control and anti-inflammatory medications fail to control the disease processes themselves. Gene-therapy strategies may offer therapies that can modify or abort the inflammatory processes attaching joint tissue, and may deliver biologically active DNA to critical morphological and biochemical points in these diseases. Such techniques as cell-mediated transport may allow highly selective treatments for these diseases.