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Antibody response of susceptible and resistant chickens (type-II leukosis) infected with JM and JM-V leukosis strains and herpesvirus of turkeys (HVT).

SUMMARY Experiments were carried out to: 1) investigate the differences in antibody response of chickens to different leukosis antigens (JM, JMV, JMV-A), as well as HVT; and 2) to determine the differences in antibody response between susceptible (P-line) and resistant (Nline) chickens to these antigens by means of the serum-neutralization test. Cell-free JMV and chicken-embryo-modified JMV-A leukosis strains stimulated chickens (both P- and N-line) to produce significantly (P<0.001) high levels of neutralizing antibody (against JM virus) which completely protected the birds from challenge by high doses of cellular JMV. By comparison the same lines of chickens, vaccinated with HVT or naturally exposed to JM virus, did not produce significant levels of neutralizing antibody against JM. Although HVT-vaccinated chickens did show some (though incomplete) protective ability against JMV challenge, JM-exposed and unvaccinated control birds showed almost no protection. At 3, 6, and 10 weeks postvaccination, no virus was recovered from kidney cell cultures from birds vaccinated with JMV or JMVA or from unvaccinated isolated controls, whereas kidney cultures from HVT-vaccinated and JM-exposed chickens showed consistent cytopathic effects.