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[Circadian blood pressure profile in patients with metabolic syndrome and osteoarthrosis during therapy with nonsteroidal anti-inflammatory drugs].

Twenty-three patients with metabolic syndrome (MS) concurrent with ostearthrosis (OA) who had been long taking various nonsteroidal anti-inflammatory drugs (NSAID) (a study group) and 23 patients with MS without locomotor diseases (a control group) were examined. The groups were matched by gender, age, body mass index, and office blood pressure values. All the patients underwent 24-hour blood pressure (BP) monitoring. The mean 24-hour, mean diurnal and nocturnal variables of BP and the proportion of non-dippers were estimated in the study and control groups. In the study group, there were higher levels of the mean 24-hour systolic BP (SBP) (p = 0.044), pulse BP (p = 0.023), mean diurnal and mean nocturnal SBP (p = 0.040 and 0.036, respectively). There was also a predominance of non-dippers in the study group as compared with the control one (p = 0.037). Thus, the use of NSAID in patients with MS and concomitant OA causes negative changes in the 24-hour profile of BP.