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Stimulant effects of W-7, a calmodulin-antagonist, on renin release from rat kidney cortical slices.

Effects of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin-antagonist, on renin release was examined using rat kidney cortical slices. Although the amounts of renin release from the slices were stable during incubation of 3 consecutive 15 min periods in Krebs-Ringer bicarbonate solution (pH 7.4), the addition of W-7 to the incubation medium resulted in a concentration-dependent increase in renin release from the slices. The stimulant effect of W-7 on renin release was abolished by the removal of calcium from the incubation medium. These results suggest that the inhibition of the calcium-calmodulin system leads to the stimulation of renin release from rat kidney cortical slices.