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H.pylori infection, part I: clinical burden and diagnosis

In 1994, Helicobacter pylori infection was recognised as the primary driver of gastric carcinogenesis. Infection also has a wider impact as the causative agent in gastric MALT (mucosa‐associated lymphoid tissue) lymphoma, among other pathologies. In the first of two parts, the authors discuss the natural history and sequelae of H. pylori infection alongside identification in the clinical setting. Part II (next issue) will consider management of H. pylori infection in an era of rising antibiotic resistance.