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Post-mortem 131-I-thyroxine distribution in a hypothyroid woman.

ABSTRACT Tissue radioactivity was measured at post-mortem examination of a hypothyroid woman 4 days after iv administration of 131I-thyroxine. A study of thyroxine equilibration in 2 other hypothyroid patients indicates that 4 days is sufficient for equilibration of a single tracer thyroxine dose. The ratio of tissue to serum activity (T/S) was highest in the liver (1.95) and lowest in muscle (.07) and brain (.05). The hepatic T/S is considerably higher than that observed in experimental animals.