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Structural analysis of the O-antigen of Francisella tularensis subspecies tularensis strain OSU 10.

Francisella tularensis, the causative agent of the disease tularaemia, is one of the most infectious bacteria known. F. tularensis subspecies tularensis (type A) and holarctica (type B) are the major subspecies, with the former being highly virulent for humans (Conlan et al., 2002). A live vaccine strain (LVS) of F. tularensis empirically derived from a virulent strain of type B F. tularensis provides considerable protection against highly virulent type A strains in humans (Conlan et al., 2002; Fulop et al., 2001). Although the F. tularensis LVS is attenuated for humans, it is fully virulent for mice (Conlan et al., 2002), and infection with F. tularensis LVS in mice has been used as an experimental model of tularaemia in a number of studies.