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Excessive use of antipsychotics as a global problem of clinical medicine

In recent decades in many regions of the world there has been an increase in prescribing antipsychotics, including for children and adolescents, and in many cases the drugs are used off label, in patients without diagnosis of schizophrenia and other psychoses and bipolar disorder or — in child and adolescent practice — without severe behavioral disorders. In addition, antipsychotics are often prescribed at excessive doses, and antipsychotic therapy is not accompanied by proper monitoring of physiological functions and laboratory parameters. The metabolic effects of antipsychotics contribute to weight gain, obesity and metabolic syndrome, increase the risk of type 2 diabetes, as well as cardiovascular diseases development. Children and adolescents, as well as young adults, are particularly vulnerable to the undesirable metabolic effects of antipsychotic drugs. The deterioration of physical health due to side effects of antipsychotics is one of the reasons for reducing life expectancy in patients with mental disorders.