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[Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design].

OBJECTIVE
To optimize preparative technique for banxia-houpu effervescent tablets.


METHODS
Based on the pH, disintegration time limited, taste, and rigidity of effervescent tablets, the proper proportion between citric acid and sodium bicarbonate, as well as the proper quantity of polyethylene glycol 6000 and sodium cyclamate in the effervescent tablets were determined by using orthogonal design. The content of magnolol and honokiol in effervescent tablets were measured by HPLC.


RESULTS
The optimal preparative technique was: cirtic acid: sodium bicarbonate = 0.65:1. The percentage of polyethylene glycol 6000 was 85%, and the percentage of sodium cyclamate was 1.0%.


CONCLUSION
The preparative technique is stable, reliable and suitable for practical use.