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Multiple Myeloma and Peripheral Neuropathy in Myotonic Dystrophy Type 2 (DM2).

Myotonic dystrophy type 2 (DM2) is a phenotypically heterogeneous multisystem disorder, most dramatically involving the nervous system. Although multisystem involvement is common in this disease, we present a genetically proven DM2 patient with both peripheral neuropathy and blood dyscrasia, previously unreported in the literature, suggesting a distinct phenotype in this population. Routine electrophoresis in DM2 patients with neuropathy is recommended, and implications surrounding the etiology of peripheral neuropathy and paraproteinemia in DM2 are discussed.