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A Positive Correlation of Pcrn to Ktn in Cross-Sectional Studies is Not Proof of a Causal Relationship

Editar: I am convinced that the conclusions reached in my recent editorial (1) concerning the mathematical relationships between the normalized protein catabolic rate (PCRN) and KTN are only partially correct. As a result of recent discussions concerning the difficulty studying two interrelated variables in a crosssectional database (2), I have reconsidered this issue and would like to submit the following brief analysis of the PCRN-KT/V relationship in continuous ambulatory peritoneal dialysis (CAPD) and revise some of the conclusions reached in my editorial. Urea kinetic modeling is based on the law of conservation of mass. The urea nitrogen mass balance equation for continuous CAPD therapy can be written as