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RATIO OF AMNIOTIC FLUID CORTISOL AND MATERNAL SERUM CORTISOL (AFC/MSC) AS AN INDEX OF FETAL LUNG MATURITY

Abstract. Fifty‐eight samples of amniotic fluid from pregnant women between the gestation period of 34‐42 weeks were analyzed for total cortisol levels. Thirty‐four simultaneous maternal serum total cortisol levels were also measured. Amniotic fluid cortisol (AFC), maternal serum cortisol (MSC) and the ratio of AFC/MSC were correlated with L/S ratio. AFC alone and AFC/MSC ratios correlate with L/S ratios (r=0.36, p <0.01, and r=0.46, p <0.01, respectively). MSC and L/S ratios had no correlation. AFC/MSC had less individual variation as compared to AFC alone. The AFC/MSC had less individual variation as compared to AFC alone. The AFC/MSC could be divided by an arbitrary line at 0.1 and values less than 0.1 signify immature fetal lungs. Values of 0.1 and greater signify mature fetal lungs.