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An RNA Binding Protein Negatively Controlling Differentiation in Fission Yeast

ABSTRACT The fission yeast Schizosaccharomyces pombe starts sexual development when starved for nutrients and simultaneously activated by mating pheromones. We have identified a new gene regulating the onset of this process. This gene, callednrd1+, encodes a typical RNA binding protein that preferentially binds poly(U). Deletion ofnrd1 + causes cells to initiate sexual development without nutrient starvation. We have found that the biological role of nrd1 + is to block the onset of sexual development by repressing the Ste11-regulated genes essential for conjugation and meiosis until cells reach a critical level of starvation.