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Transient global amnesia and hippocampal foci of restricted diffusion

A 63-year-old man was admitted owing to the onset upon awakening of anterograde amnesia and spatio-temporal disorientation accompanied by repetitive questioning. No disturbances of consciousness and self-awareness or others focal neurological symptoms were found. The EEG examination was normal.

The patient had no medical history for neurological abnormalities or neuroactive drugs and no cardiovascular risk factors. The symptoms resolved spontaneously within 24 h, with no persistent neurological impairment.

A brain MRI examination, performed 48 h after the onset, showed bilateral hippocampal restricted diffusion foci with low apparent diffusion coefficient …