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Sustained Release Properties of Aminophylline Sustained Release Tablets Based on Exfoliated Graphite

This study attempted to develop sustained release tablets based on exfoliated graphite. The in vitro evaluation of the prepared tablets was carried out to study its sustained release properties by means of UV/VIS spectroscopy. The results show that the release rate of aminophylline decreases with the increase of the content of graphite for the aminophylline sustained release tablets based on exfoliated graphite. The graphite in the aminophylline sustained release tablets will delay the release of aminophylline when the exfoliated graphite content in the sustained release tablets is less than 25%, the graphite will prevent the release of a part of the aminophylline when the exfoliated graphite content exceeds 40%. The reproducibility of the prepared aminophylline sustained release tablets is acceptable.