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Hepatic amino acid transport primary to the urea cycle in regulation of biologic neutrality.

A biologic determination appears to be made as to whether the nitrogenous portion of food amino acids reaches the kidney for excretion as ammonium ion, or whether it is sent to the liver to form urea. It now becomes likely that this determination occurs primarily by hydrogen ion inhibition of at least one transport system by which the liver receives amino acids, and not by regulation applied directly to the liver-ornithine cycle.