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Gas-Assisted Release of Vitreomacular Adhesion in Wet Age-Related Macular Degeneration

Gas-Assisted Release of Vitreomacular Adhesion in Wet Age-Related Macular Degeneration Vitreomacular adhesion (VMA) means attached posterior hyaloid to the foveal area when a partial posterior vitreous detachment exists. Vitreomacular adhesion is a risk factor for wet age-related macular degeneration and also antagonizes anti–vascular endothelial growth factor treatment for wet age-related macular degeneration. Trans pars plana vitrectomy has drawbacks such as risk, cost, and suboptimal dosing of anti–vascular endothelial growth factor because of increased clearance of drug. Microplasmin is now being tested, but success rate of posterior vitreous detachment is only 44%. Previous reports have shown that vitreous injection of plasmin combined with SF6 could induce posterior vitreous detachment in rabbit eyes. Here, we report a very simple method of releasing VMA using intravitreal C3F8 gas at the time of anti– vascular endothelial growth factor treatment.