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THE INFLUENCE OF QUERCETIN ON THE HEPATIC DIFFERENTIATION OF HUMAN ADIPOSE-DERIVED MESENCHYMAL STEM CELLS.

The human adipose-derived mesenchymal stem cells was shown to be hepatic differentiated under influence
of inductor factors. The differentiation of MSCs was induced by fibroblast growth factor-4, hepatocyte
growth factor, oncostatin M and dexamethasone. The influence of quercetin on the hepatic differentiation of
MSCs in culture was investigated. The adding quercetin into induction medium (1 or 10 mmol/l) enhanced the
manifestation of signs of hepatic differentiation MSCs such as urea secretion, cytokeratin 19 and a-fetoprotein
synthesis. Quercetin modulating action on the CYP1A — cytochrome P450 activity in differentiated cells was
found. MSCs which was differentiated in the presence of quercetin had a higher viability and resistance to oxidative
stress.