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Chromosome 22: a model with implications for diagnostic imaging.

lar cytogenetics. These advances have led to a greater understanding of the structure and function of chromosomes and have increased sensitivity in the identification of chromosomes and genes. Cytogenetic techniques have contributed significantly to physical mapping of chromosomes and have led to the localization of the genes involved in many inherited disorders. This review will use chromosome 22 (Ch 22) as a model to introduce radiologists to the striking progress that has been made by our colleagues in cytogenetics and to describe some of the protean diseases that are manifested by abnormalities at various sites on this chromosome.