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Trans-capsaicin for Pain Reduction and Function Improvement in Patients With Knee Osteoarthritis.

We thank Drs. Yu and Lu for their interest in the recent publication of results from our phase 2 trial (Stevens RM, et al. Randomized, Double-Blind, Placebo-Controlled Trial of Intraarticular Trans-Capsaicin for Pain Associated With Osteoarthritis of the Knee. Arthritis Rheumatol. 2019;71:1524-33). However, we respectfully disagree that our study did not have a placebo-control group. All three study groups were treated identically except for the presence or absence of injected capsaicin.