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Increase in killer‐specific secretory protein of 37 kDa in bronchoalveolar lavage fluid of allergen‐challenged patients with atopic asthma

Background Atopic asthma is linked to a T‐helper type 2 dominated pathogenesis, but there is increasing evidence of Th1/Tc1‐mediated processes in the aetiopathology of asthma. Killer‐specific secretory protein of 37 kDa (Ksp37) is expressed in cytotoxic lymphocytes, selectively in the effector subsets of CD8+‐ and CD4+ T lymphocytes and in CD16+/CD56dim natural killer cells and γ/δ T cells. This effector cell‐specific expression of Ksp37 and its coexpression with perforin suggest that Ksp37 might be involved in processes mediated by cytotoxic cells.