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Old and new plasma biomarkers in HIV-1-infected African-American women.

The search of correlates of HIV disease progression (or of its lack) that may shed light on its immunopathogenesis has been pursued for decades, starting with ‘old markers’ such as neopterin [1] and acid-labile interferon-a (IFNa) [2]. Both biomarkers showed a tight correlation with the secretion of IFNg by immune cells [in particular by, CD4þ T helper-1 (Th1) cells, CD8þ T lymphocytes and natural killer cells] activated, directly or indirectly, by the HIV replication.