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Cellular origin and diagnostic significance of high‐fluorescent cells in cerebrospinal fluid detected by the XE‐5000 hematology analyzer

The Sysmex XE‐5000 is a blood and body fluid analyzer able to differentiate cells into polymorphonuclear, mononuclear, and high‐fluorescent cells (HFC). The identity of HFC in cerebrospinal fluid (CSF) has been uncertain; however, compatible with their high nucleic acid content, HFC could represent intrathecal tumor cells. Here, we studied the cellular origin and the diagnostic significance of HFC in CSF.