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Biodistribution of Evans blue in an orthotopic AY‐27 rat bladder urothelial cell carcinoma model: implication for the improved diagnosis of non‐muscle‐invasive bladder cancer (NMIBC) using dye‐guided white‐light cystoscopy

To investigate the possibility of using Evans blue (EB) as a novel diagnostic tool to detect bladder tumours with white‐light (WL) cystoscopy, in this preclinical study we examine the biodistribution of EB in the different layers (urothelium, submucosa, muscle) of a normal rat bladder and a rat bladder bearing a malignant urothelium composed of syngeneic AY‐27 tumour cells.