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Constructing Pain: Historical, Psychological, and Critical Perspectives (Critical Approaches to Health)

The field studying transient receptor potential (TRP) channels, while less than fifty years old, has grown precipitously in the past few decades, revealing roles for these channels across multiple organ systems and sensory modalities. Editor Tamara Luti Rosenbaum Emir, along with a multitude of authors who are experts in their fields, truly capture the scope and complexity of these channels in the book, Neurobiology of TRP Channels. The book offers a comprehensive overview of TRP channels starting from the differences in basic structure and amino acid sequence between TRP channel subfamilies. Following this introductory chapter, the book opens up into a more loosely structured format in which the chapter topics range from molecular mechanisms of ion channel gating to roles of TRP channels in specific organs as well as the role of these channels in more complex processes such as perception and ageing. The text is also thorough in how it breaks down each chapter. For example, in chapter 8 of the book, titled “TRP Channels and Pain,” the authors break down the chapter by addressing each variant of TRP channels involved in pain signaling separately. Not only that, each subsection pertaining to the individual channel variants are further divided into different forms of pain, such as inflammatory pain versus neuropathic pain. This pattern is generally maintained throughout the entirety of the book. Similarly, in sections that are centered on the role of TRP channels in individual organs, the chapter begins by explaining the normal function of TRP channels within the organ before diving into how the channels are involved in the pathophysiology of relevant disease states. This organization presents a clear step by the authors to delineate complicated, and oftentimes overlapping, signaling cascades as much as possible. Furthermore, each focus chapter contains individual headings that describe smaller subtopics. This is particularly helpful in combination with the well-referenced text such that the publications and research behind the text may be easily accessible. At the end of each chapter there is an extensive list of detailed references that make it a great tool for those seeking to understand the original experimentation that informs our current knowledge of TRP channels. The figures, while a bit sparse, range from schematics and cartoons detailing the structure of TRP channels to figures taken from previously published work. The inclusion of published work in particular establishes a clear line from the data to the assertions made from these data. The book also contains a color insert in the middle in order to better distinguish multiple components in denser figures. That being said, the best audience for Neurobiology of TRP Channels is likely to be experienced students that have taken foundational courses in cellular neuroscience and neurophysiology. Moreover, the book dives into a lot of technical details from the publications that contributed to the current knowledge of TRP channels, so fundamental understanding of genetic manipulation and modern cell biology may also be required. In this way, the book may serve best as a reference, as the concepts from chapter to chapter do not necessarily build off one another as books covering larger, broader topics often do. Altogether this text is a great resource for those seeking a categorical summarization of our current understanding of TRP channels as well as the research that has allowed the field to take off in such a short period of time.