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Atypical neuroleptics in elderly patients: acute kidney injury.

Using data from health insurance databases, a Canadian team showed that patients aged 65 years or older had a statistically significant increased risk of hospitalisation with acute kidney injury within the 90 days after they were newly prescribed the oral "atypical" neuroleptics risperidone, quetiapine or olanzapine. Adverse effects that can lead to kidney injury were identified: hypotension, acute urinary retention, pneumonia, myocardial infarction and ventricular arrhythmia. All-cause mortality also increased.