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An Expedient Synthesis of 2-Aryl-substituted 2,3-Dihydroquinazolin-4(1H)-ones in
Low Transition Temperature Mixture (LTTM) containing SnCl2 and L-Proline

2,3-Dihydroquinazolin-4(1H)-ones were synthesized in excellent yield in a prepared low transition
temperature mixture (LTTM) containing SnCl2 and L-proline using either direct one-pot two-component
cyclocondensation of anthranilamide and aldehydes or one-pot three-component cyclocondensation
of isatoic anhydride, ammonium acetate and aldehydes. The prepared LTTM is a green solvent,
inexpensive, non-toxic and serves a dual function as reusable catalyst and solvent with excellent reaction
endorsing medium. The current protocol has several advantages including an easy work up, shorter
reaction time, high yield with a higher atom economy and maximum reaction efficiency with excellent
green chemistry metrics.