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Cell recognition during synaptogenesis is revealed after temperature-shock-induced perturbations in the developing fly's optic lamina.

Houseflies (Musca domestica) were exposed to pulses of heat (1 h) or cold (several hours) during early pupal life, and the effects were investigated on the development of the first optic neuropile, or lamina, of the visual system. The treatments were designed to perturb the cellular organization of the cartridges, the unit synaptic structures of the lamina, so as to provide novel synaptic opportunities among the normally fixed composition of these modules, thereby testing the preferences of their component cells during synaptogenesis. Various abnormalities were identified, but these were not always consistent between flies: retinal abnormalities included the loss and fusion of rhabdomeres, especially of the central cells of the ommatidium, whereas in the lamina low frequencies of abnormal cartridges were found. These included seven that were studied with serial sections, which instead of the normal pair of L1 and L2 monopolar interneurons had supernumerary cells of this type. The normal pairing of L1 and L2 at postsynaptic sites of receptor terminal tetrad synapses was preserved in these cases, the cells eschewing pairings of homologous L1/L2 or L2/L2 partners. This meant that more than one L1 could pair with a single L2 and vice versa, even at the same terminal, and appeared to do so opportunistically on the basis of proximity, with cells closer to each other pairing more frequently. Thus the cells behave during synaptogenesis as if they recognize other cells only as cell types (receptor, L1 or L2) and not as individual cells.