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Use of Specialized Pro‐Resolving Mediators to Alleviate Cold Platelet Storage Lesion

Cold‐stored platelets are an attractive option for treatment of actively bleeding patients due to a reduced risk of septic complications and preserved hemostatic function compared to conventional room temperature–stored platelets. However, refrigeration causes increased platelet activation and aggregate formation. Specialized pro‐resolving mediators (SPMs), cell signaling mediators biosynthesized from essential fatty acids, have been shown to modulate platelet function and activation. In this study, we sought to determine if SPMs could be used to inhibit cold‐stored platelet activation.