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Structure Formation and Interactions in Aggrecan Solutions

INTRODUCTION Aggrecan is a high molecular weight (1x10<M<3x10) proteoglycan. It exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate chains are attached to an extended protein core. In the presence of hyaluronic acid (HA) and link protein, aggrecan molecules self-assemble into a supermolecular structure with as many as 100 aggrecan monomers attached as side chains on a filament of hyaluronan. In cartilage these complexes are interspersed in the collagen matrix. This supermolecular array forms a hydrated, viscous gel that provides the osmotic properties required for the cartilage to resist deswelling under compressive load. The aim of this work is to investigate the spatial organization both in solutions of pure aggrecan and in solutions containing aggrecan hyaluronic acid complexes. The static properties are studied by osmotic pressure measurements, and small angle neutron scattering (SANS)), while the dynamics are probed by dynamic light scattering (DLS).