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The HO-1/CO System and Mitochondrial Quality Control in Skeletal Muscle

Skeletal muscle HO-1/CO system activation by exercise and exogenous CO is critical for regulating mitochondrial dynamics and biogenesis. Inducible heme oxygenase (HO)–1 catalyzes the breakdown of heme to biliverdin, iron, and carbon monoxide (CO). CO binds to cytochrome c oxidase and alters mitochondrial redox balance and coordinately regulates mitochondrial quality control (MQC) during oxidant stress and inflammation. The hypothesis presented is that the skeletal muscle HO-1/CO system helps modulate components in the MQC cycle during metabolic stress.