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The air we breathe: three vital respiratory gases and the red blood cell: oxygen, nitric oxide, and carbon dioxide

Three vital respiratory gases—oxygen (O2), nitric oxide (NO), and carbon dioxide (CO2)—intersect at the level of the human red blood cell (RBC). In addition to hemoglobin (Hb)'s central role in O2 transport, interaction of Hb with the Band 3 metabolon balances RBC energy flow. 2,3‐Diphosphoglycerate enhances O2 transport across the placenta and plays an important role in regulating RBC plasticity.