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Effects of Demetrin on circulation.

In a double-blind study the influence of Demetrin on cardiovascular activity was investigated. Basic values before treatment were compared with values after 1 and 2 weeks' administration. The cardiovascular parameters "pulse rate" and "blood pressure" were studied in the orthostatic tolerance test (pivoting table) and in the bicycle ergometer test. Results were evaluated with variance analysis. Demetrin at dosage levels of 3 x 10 mg/day and 3 x 20 mg/day did not influence cardiovascular function. Occasionally mild sedation was observed.