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Recurrent erythroblastopenia associated with Varicella zoster virus infection in an infant

Transient erythroblastopenia of childhood (TEC) is an acquired, self-limiting, benign disorder characterized by the transient disappearance of erythroblasts from the bone marrow resulting in reticulocytopenia in the blood and the development of moderate to severe normochromic normocytic anemia. 1 It usually affects previously healthy children aged 6 months to 3 years, resolves spontaneously within a few weeks from diagnosis, and does not recur. 2 Although the etiology of TEC is unclear, viral infection has been suspected as a possible trigger. For instance, human parvovirus B19 (HPV) directly infects the erythroid progenitor cells and induces the development of TEC according to reports published previously. 3 Other studies of TEC have shown that normal erythropoiesis is impaired by autologous IgG, 4 IgM 5