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PGC1α alleviates mitochondrial dysfunction via TFEB‐mediated autophagy in acute kidney injury mice

Cisplatin is a widely used chemotherapy drug, and always led to nephrotoxicity via causing mitochondrial dysfunction. PGC‐1α, a regulator of mitochondrial biogenesis, has been recently reported to activate TFEB‐mediated autophagy, which could remove damaged mitochondria. However, The role of PGC1α/TFEB pathway remains unknown in AKI. Thus, we aim to investigate whether the activator of PGC‐1α (ZLN005) could alleviate mitochondria dysfunction though TFEB‐mediated autophagy in AKI mice.