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Superimposed Segmental Hemangioma of Infancy

Background: Segmental hemangioma of infancy is sometimes associated with the development of multiple nonsegmental hemangiomas. Such co-occurrences have so far remained unexplained. Methods and Results: Pertinent reports were collected from the literature. To explicate such cases, the following concept is proposed. Hemangiomas of infancy reflect a polygenic predisposition. Nonsegmental lesions result from a mutational event occurring at a late stage of intrauterine life or after birth, whereas segmental hemangioma originates from loss of heterozygosity or some other mutational event arising at an early developmental stage. Conclusion: In this way, segmental hemangioma of infancy could be taken as a further example of the superimposed segmental manifestation of a polygenic skin disorder. Future molecular research may show whether this assumption holds true.