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[The correlation between the expression of AQP1 and angiogenesis ability in nasopharyngeal carcinoma].

OBJECTIVE
To investigate the expression and correlation of Aquaporin-1 (AQP1), VEGF and MVD in nasopharyngeal tumor and non-tumor tissues.


METHOD
Thirty nasopharyngeal biopsy samples were collected and examined with both immunohistochemistry and real-time fluorescence quantitative PCR (RT-PCR) to detect the expression level of AQP1 and VEGF in tissues. MVD were then calculated.


RESULT
Both immunohistochemistry and RT-PCR showed higher expression of AQP1 and VEGF in tumor tissues than in non-tumor tissues. The two factors were positively correlated.


CONCLUSION
In nasopharyngeal carcinoma, AQP1 may participate in angiogenesis by VEGF. Thus it may facilitate the tumor's growing and metastasis.