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Effects of antiarrhythmic drugs on QT interval dispersion--relationship to antiarrhythmic action and proarrhythmia.

Class IA, IC, and III antiarrhythmic drugs prolong ventricular repolarization (VR) which is manifest as QT interval prolongation on the surface electrocardiogram. These drugs may prolong VR in a spatially heterogeneous manner which results in increased dispersion of VR. This may be manifest as increased QT interval dispersion. Antiarrhythmic drug-induced decreases in QT interval dispersion are associated with antiarrhythmic efficacy in patients with the long QT syndrome and in patients with sustained ventricular tachycardia. Antiarrhythmic drug-induced increases in QT interval dispersion are associated with ventricular proarrhythmia secondary to torsades de points ventricular tachycardia. A number of factors may modulate the effects of antiarrhythmic drugs on dispersion of VR, including the disease state, transient ischemia, electrolyte abnormalities, changes in autonomic tone, and hemodynamic stress.