{'fraction_non_alphanumeric': 0.06504770164787511, 'fraction_numerical': 0.0372940156114484, 'mean_word_length': 4.417840375586854, 'pattern_counts': {'":': 0, '<': 1, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
ALDOSTERONE--A POTENT STIMULATOR OF THE RENAL KALLIKREIN-KININ SYSTEM DURING FETAL LIFE

The effects of acute (A) (0.25 ug/min/kg body wt. over 2 hrs) and chronic (C) (0.50 ug/kg over 4 days) aldosterone infusion (Aldo-I) on active urinary kallikrein (UKall) and Na+ excretion (UNa+V) were studied in young (95-115 days, n=6) and old ( 125 days, n=8) fetal lambs (term 145 days) chronically instrumented. A-Aldo-I was not associated with changes in plasma electrolytes concentration but produced a significant decrease in UNa+V in both groups of fetuses and a rise in UKall in young fetuses. C-Aldo-I produced a significant (p<0.05) rise in plasma Na+ (142±1 to 147±1 meq/1 meq/1) and decline in plasma K+ (4.7±0.3 to 4.0±0.2 meq/l) in old fetuses and was associated with decreases in UNa+V and increases in UKall in both groups of fetuses.All values were back to baseline levels 3 days after stopping C-Aldo-I. The present results demonstrate that Aldo is a potent modulator of Na+ reabsorption and UKall production very early during gestation and suggests a link between the kallikrein-kinin and renin-angiotensin-aldosterone system during fetal life.