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Central components of the renin‐angiotensin system

1 Re‐establishment of renal blood flow after total renal ischaemia of 4 h duration causes a pressor response in pentobarbitone anaesthetized rats and cats. 2 The pressor response is related to the release of renin from the ischaemic kidney. 3 Spinal section at any cervical level or stellate ganglionectomy abolishes the pressor response but spinal section caudad to the thorax or vagotomy and treatment with hexamethonium have no effect. 4 Spinal section and stellate ganglionectomy interfere with the release of renin and with the pressor response to angiotensin.