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Hepatic reinnervation following orthotopic liver transplantation in man

We have studied changes in the pattern of intrinsic hepatic innervation in sequential liver biopsies from 16 patients who underwent orthotopic liver transplantation. Seventy‐one needle biopsies were used, including specimens obtained at the time of transplantation (time zero) and up to 4 years post‐transplantation; five transplant hepatectomy tissue blocks removed 3–32 months after transplantation were also assessed. Paraffin sections were immunostained with anti‐PGP 9.5 and anti‐S‐100 to identify nerve fibres.