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Prognostic relevance of serum‐markers in relation to histopathology, stage and initial symptoms in advanced low‐grade non‐Hodgkin lymphomas

The prognostic relevance of 4 different serum markers (deoxythymidine kinase = S‐TK, lactic dehydrogenase = S‐LDH, S‐Haptoglobin and S‐Orosomucoid) in relation to histopathology according to the Kiel classification, stage and presence or absence of initial symptoms were investigated in 168 consecutive cases of low‐grade non‐Hodgkin lymphomas (NHL). All serum markers, as well as the other three parameters, gave prognostic information. Univariate analysis yielded a high predictive value (p<0.0002) for both S‐TK and S‐LDH. The best information regarding the probability of survival was, however, obtained from the presence or absence of symptoms from lymphoma manifestations other than those caused by a strictly local tumor mass. Since S‐TK and S‐LDH correlated well with each other, only the better of them, S‐TK, gave information additional to initial symptoms in a multivariate test.