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Age at menarche and breast cancer.

Breast cancer risk and age at menarche are shown to be indirectly associated with nutrition being the possible common factor in a case-control study in the Katowice and Opole Districts of Poland. In Athens and Boston where breast cancer incidence is high cases of late menarche (> 16 years) are low compared to Tokyo and much lower than Poland. Menarche at < 16 years indicated breast cancer risks 1.76 as high as those reporting late menarche. The risk differential was more distinct for women up to 44 years than for older women. Late menarche is associated with nutritional status. Dietary patterns may affect breast cancer risk as do geographical patterns. Migration from a low-risk location i.e. Poland to a high-risk location the U.S. increases risk of breast cancer. The decreasing numbers of women with late menarche in Poland indicate the risk of breast cancer will continue to rise.