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Pretreatment with aspirin does not influence the pressor response to α2‐adrenoceptor agonists in conscious rabbits

It has proved relatively easy to demonstrate pressor responses mediated via α2‐adrenoceptors in‐vivo and in whole blood perfused vascular beds, but not in in‐vitro work. The possibility that platelet α2‐adrenoceptor activation, with subsequent release of vasoactive prostanoids, contributes to the pressor response to α2‐adrenoceptor agonists was investigated. The pressor response to the α2‐adrenoceptor agonist BHT 920 (Alefexole) was compared in rabbits pretreated with distilled water or aspirin (3 times 200 mg kg−1 by gavage). Aspirin pretreatment had no significant effect on responses to BHT 920; thus, prostanoid formation does not appear to be an important mechanism contributing to postsynaptic α2‐adrenoceptor activation.