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Aortic pulse wave velocity and augmentation index@75 measured by oscillometric pulse wave analysis in Gujarati nonhypertensives

BACKGROUND: Augmentation indexes (AIxs) and pulse wave velocity (PWV) are arterial stiffness parameters. They can be studied by pulse wave analysis (PWA) noninvasively. Before use, AIx and PWV need normative baseline study to find the predictors. MATERIALS AND METHODS: We conducted a cross-sectional study in 801 nonhypertensives, aged 15–65 (divided into five subgroups) years. PWA was accomplished by Mobil-o-Graph (IEM, Germany) based on oscillometric principle and cardiovascular parameters reported were further analyzed. Value of P < 0.05 was taken as statistical significance. RESULTS: There were five age-based subgroups from 15 to 65 years, showing an increase in AIx@75 and PWV with age. Females had significantly higher AIx in male in age groups (31.4 vs. 25.8, 34.95 vs. 27.21, 32.62 vs. 27.61, 34.32 vs. 26.36, 37.09 vs. 29.63; P < 0.05 for all), but PWV was higher in males than females in young age group (15–24 years-4.94 vs. 4.71, 25–34 years-5.28 vs. 5.12, 35–44 years-6.00 vs. 5.84; P < 0.05 in all) and in females than males in older age group (45–54 years-6.88 vs. 6.78,55–65 years-8.13 vs. 8.03). Major positive significant predictors of PWV were age, Body Mass Index, and systolic blood pressure; and of AIx@75 were age, height (negative), heart rate, and pulse pressure. AIx@75 and PWV showed a positive correlation with each other across all age group in either sex except for 55–65 years and 25–34 years age groups. CONCLUSIONS: Oscillometric measurement of PWV and AIx@75 is feasible in our population. They are dependent on each other and age, totally not dependent on blood pressure and have difference in predictors. This baseline data can be used as a reference for future studies.