{'fraction_non_alphanumeric': 0.04439252336448598, 'fraction_numerical': 0.054906542056074766, 'mean_word_length': 4.490384615384615, 'pattern_counts': {'":': 0, '<': 1, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
C-reactive Protein, Infection, and Outcome After Acute Ischemic Stroke: A Registry and Systematic Review.

BACKGROUND
A body of studies have explored the prognostic role of CRP on patients with acute ischemic stroke, however, the results have been inconclusive. The aim of our study was to investigate the impact of infection on the association between CRP and 3-month functional outcome by performing a registry study and systematic review.


METHODS
Patients admitted within 24 hours of acute ischemic stroke onset and had CRP measured within 24 hours after admission was included. Patients admitted between June 2016 and December 2018 in Chengdu Stoke Registry were enrolled. The PubMed database was searched up to July 2019 to identify eligible studies. We defined poor outcome as modified Rankin Scale scores at 3-month more than 3.


RESULTS
Totally, 368 patients in registry and 18 studies involving 15238 patients in systematic review were included. We found a statistically significant association between CRP values on admission and 3-month poor outcome in patients without infection, both in our registry (CRP per 1-mg/L increment, OR 1.04, 95% CI 1.01 to 1.07, p=0.008) and meta-analysis (CRP per 1-mg/dL increment, OR 1.66 [95% CI 1.37 to 2.01, p<0.001]). In patients with infection, CRP was not associated with 3-month poor outcome according to registry data (OR 1.00, 95% CI 0.99 to 1.01, p=0.663) and meta-analysis (OR 1.01, 95% CI 0.99 to 1.01, p=0.128).


CONCLUSION
High CRP value was independently associated with 3-month poor outcome after stroke in patients without infection. Further studies are warranted to examine the value of infection on CRP measures and long-term functional outcome.