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Differential expression of indole alkaloid pathway genes across Catharanthus roseus plant organs

Vinblastine and vincristine are two indole alkaloids of the medicinal plant Catharanthus roseus, widely used in cancer chemotherapy such as leukemia, Hodgkin's disease and solid tumors. Transcriptomic data of C. roseus across different organs (stem, hairy root, flower, immature and mature leaves) was collected and de novo assembled then differential expression analysis was achieved. The target of this study was the detection of components of terpenoid indole alkaloid pathway based on gene expression analysis. The in-silico analysis was focused on six genes (SLS, sgd, STR1, OMT, DAT and G8H) of the TIA pathway that were expressed in different plant organs. The results indicated posability of formed enzyme in organ and transfer to other organs to work and restore the TIA pathway. The highest expressions level of most TIA key genes took places in root, flowers and mature leaves.