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AB0117 Association of vitamin d deficiency with crp/acpa positivity in algerian patients with rheumatoid arthritis

Background Vitamin D (VD) is a steroid hormone belonging to the class of secosteroids with myriad immune functions and seems to be involved in the development and severity of rheumatoid arthritis (RA).1–3 Objectives The aim of this study was to estimate the prevalence of vitamin D deficiency in patients with rheumatoid arthritis as compared to healthy controls and to analyse the association between levels of vitamin D and CRP(C-reactive protein)/ACPA (anti citrullinated protein antibodies) positivity. Methods Serum 25(OH)D levels were measured in 115 RA patients and 104 age- and gender-matched healthy controls using the chemiluminescent immunoassay method (CLIA). CRP (mg/dl) was measured by the nephelometric method and ACPA antibodies were evaluated using enzymatic linked immuno-assay (ELISA). Results There was no statistically significant difference between levels of 25(OH)D in RA (25.08±9.22 ng/ml) and healthy controls (15.62±5.34 ng/ml). The vitamin D deficiency (<10 ng/ml) was found in 10% of RA patients, while 60% were insufficient (<20 ng/ml). Low 25-OHD levels were negatively associated with CRP (23 ng/ml vs 29 ng/ml; p=0,023) and ACPA positivity (23 ng/ml vs 28 ng/ml; p=0, 03). Conclusions The 25(OH) D levels are inversely related to CRP and ACPA values in Algerian RA patients. References [1] Lee YH, Bae SC. Vitamin D level in rheumatoid arthritis and its correlation with the disease activity: a meta-analysis. Clin Exp Rheumatol. 2016Sep–Oct;34(5):827–833. [2] Bragazzi NL, Watad A, Neumann SG, et al.Vitamin D and rheumatoid arthritis: an ongoing mystery. Curr Opin Rheumatol2017Jul;29(4):378–388. [3] Ishikawa LLW, Colavite PM, Fraga-Silva TFC, et al. Vitamin D Deficiency and Rheumatoid Arthritis. Clin Rev Allergy Immunol2017Jun;52(3):373–388. Disclosure of Interest None declared