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Increased platelet aggregation in diabetes mellitus.

Platelet aggregation to adenosine diphosphate (ADP) was found to be increased in 48.2% of a group of 58 diabetic subjects. The platelet percentage aggregation (38.6 ± 11%) of those with clinical complications was significantly higher (p 0.001) than that of uncomplicated patients (21 ± 8%). The incidence of increased platelet aggregation in the female diabetics (11 out of 13) was significantly higher than that in the male cohort (17 out of 45) the reason for which is not known. Duration of disease, mode of therapy and isolated fasting blood glucose levels did not appear to influence platelet aggregability.