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Metabolic Correlates in Spinal Cord Compression Measured by Magnetic Resonance Spectroscopy in the Motor and Sensory Cortices

ii Co-Authorship Statement iii Dedication iv Acknowledgements v List of Tables viii List of Figures ix List of Appendices x Chapter 1 1 1 Introduction to Cervical Myelopathy and Magnetic Resonance Spectroscopy 1 1.1 Background and Motivation 1 1.2 Anatomy and Physiology of the Cervical Spine 5 1.2.1 The Cervical Vertebrae 5 1.2.2 Intervertebral Discs 7 1.2.3 The Spinal Cord 8 1.2.4 Principal Descending Tracts 8 1.2.5 Principal Ascending Tracts 9 1.2.6 Motor and Sensory Cortex 10 1.3 Magnetic Resonance Spectroscopy 12 1.3.1 Characteristics of a H MR Spectrum 14 1.3.2 Measurement of Metabolite Concentration 15 1.3.3 Thesis Objectives 18 Chapter 2 28 2 Magnetic Resonance Spectroscopy in the Motor and Sensory Cortices Following Surgery for Cervical Myelopathy 28 2.1 Introduction 28