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[Ultrastructural and cellular functional activity changes in the zona fasciculata of the rat adrenal cortex resulting form the prolonged administration of adrenocorticotropic hormone].

The fasciculata zone cell ultrastructure has been studied in addition to the level of steroidogenesis of rat adrenal glands on days 2,7 and 13 after the administration of ACTH with prolonged action. The marked changes in the ultrastructure of different cells have been noticed, some of which suggest a compensatory stimulation of hormone production, and the others indicate irreversible subcellular injuries. Changes in the cell ultrastructure show the phase character in time to correlate with changes in the activity of the corticosteroid synthesis and secretion.