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Roles of large and small arteries in vascular disease: pitfalls in interpreting ethnic variations.

Hypertension is well recognized for inflicting a considerable deleterious burden upon target organs such as the brain, heart and kidney. There is a clear association between the severity and duration of high blood pressure and changes in the structure of the left ventricle and blood vessels throughout the circulation. Indeed, left ventricular hypertrophy and an increased wall–lumen ratio of small arteries are both strong predictors of increased mortality and morbidity from coronary heart disease and stroke [1,2].