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THE RELATIVE WEIGHT OF THE GRAY AND WHITE MATTER OF THE NORMAL HUMAN BRAIN

The relative proportion of gray and white matter of the normal human brain was determined to be approximately 60% and 40% respectively in the cerebral hemispheres and in the brain as a whole, by calculations based on the water content of these tissues. With this technique, the value for gray matter is an approximate measure of a myelin-free abstraction, rather than of the actual anatomic gray structures; e.g. structures such as the globus pallidus which contain many myelinated fibers would act as a mixture of tissues, and would not be included entirely with the gray matter. This abstraction may have pathological significance.