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Identification and regulation of the promoter for PEPCK‐C in epithelial cells of mammary gland

The cytosolic form of phosphoenolpyruvate carboxykinase (PEPCK‐C) has been proven to play an important role in both carbohydrate and lipid metabolism. PEPCK‐C gene is expressed primarily in the liver, kidney, adipose tissue, and the mammary gland. Because the role of PEPCK‐C in mammary gland is still unclear, we proposed to test the role of PEPCK‐C gene in the mammary gland. The mammary gland is composed of two cell types, adipocytes and epithelial cells. We hypothesize that PEPCK‐C is required for glyceroneogenesis. By the deletion analysis of PEPCK‐C promoter, we found the region from −490bp to −260bp is required for the expression of PEPCK‐C gene in NMuMG cells, a mammary epithelial cell line. We are investigating the regulation of PEPCK‐C in the NMuMG cells.