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Successful management of thrombotic thrombocytopenic purpura in a Jehovah's Witness without plasma exchange

Thrombotic thrombocytopenic purpura (TTP) is a hematologic emergency characterized by microangiopathic hemolytic anemia and thrombocytopenia. Plasma exchange is the standard treatment. Treating TTP without plasma exchange is a challenge. Due to religious beliefs, Jehovah's Witnesses do not accept transfusions of blood products. We report a case of successful treatment of TTP in a Jehovah's Witness using plasma exchange with albumin replacement. J. Clin. Apheresis 30:46–49, 2015. © 2014 Wiley Periodicals, Inc.