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Permeability of the blood‐retinal barrier in myopia: An analysis employing vitreous fluorophotometry and computer simulation

Vitreous fluorophotometry was performed in 165 eyes of 93 cases with various degrees of myopia. The age range was 10-39 years. On background of the significant correlation between the refractive diopter value and the length of vitreous cavity, a simulation model for myopia has been established for assessing the permeability of the blood-retinal barrier. Significant negative correlations between the diopter and P-in and the diopter and D-p were found, indicating that by increasing degree of myopia, the functional disorder of the blood-retinal barrier and the liquefaction of the posterior vitreous gel progress. From the comparative study between eyes with slight myopia and eyes with emmetropia, a significant increase in the length of the vitreous cavity and P-in was found in the former, whereas no significant difference was observed in D-p. Therefore, it is suggested that the functional disorder of the blood-retinal barrier in myopia produces the liquefaction of the posterior vitreous gel.