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NEUROCHEMISTRY OF THE SPINAL CORD IN CONGENITAL TREMOR OF PIGLETS (TYPE AII), A SPINAL DYSMYELTMOGENESIS OF INFECTIOUS ORIGIN

Abstract— In piglets affected with congenital tremor type AII the CNS was not morphologically underdeveloped; spinal cord weight, total DNA content and fat‐free dry matter differed little from control values. However the total lipid extractable from affected spinal cords was only about 63% of values established for normal newborn piglets. In particular, the cerebroside content (a myelin‐specific lipid) was reduced to about 30% of the ‘normal’ value. This was parallelled by the results of an in vitro assay of cerebroside synthesis from [3H]galactose which indicated a metabolic impairment. The altered fatty acid profile of isolatcd cerebrosides further suggested a derangement of fatty acid synthesis. Unlike the spinal cords of normal newborn piglets, tissues from affected piglets contained significant amounts of cholesterol esters carrying the characteristic fatty acids associated with demyelination. This implied that the reduced quantities of possibly abnormal myelin were unstable. Abnormal swollen oligodendrocytes were commonly present in the spinal cords of affected piglets and this was consistcnt with the observed impairment of myelin formation.