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Force-Carrying Web Pervades Living Cell

A team of cell biologists has demonstrated that mammalian cells are densely "hard-wired" with force-carrying connections that reach all the way from the membrane through the cytoskeleton to the genome. The group combined micromanipulation, video microscopy, and molecular adhesives to show that tugging on particular receptors at the cell surface triggers nearly instantaneous rearrangements in the nucleus. The demonstration supports the idea that cytoskeletal connections could transmit regulatory information throughout the cell.