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Flow and mass transfer modelling for tissue engineering applications

Recent advances in tissue engineering (Seal et al. 2001) have led physicians and surgeons to consider and start introducing these techniques into their clinical practice. A wide range of tissues have been studied, from the bone to the liver. Bioreactors are a promising technology for culturing cells in dynamic conditions and engineering tissues ex vivo (Portner et al. 2005). The aim of this study is to demonstrate and display how modelling tools help design bioreactor-based systems and characterise mass transfers, fluid flow and the mechanical environment to which the cells are submitted.