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Oestrogen Receptor Studies in Carcinoma of the Endometrium, Carcinoma of the Uterine Cervix and other Gynaecological Malignancies

Summary: The tissues from 30 cases of endometrial cancer and 44 cases of cervical cancer were examined for oestrogen receptor activity. Twenty of the endometrial and 9 of the cervical tumours contained oestrogen receptor levels above 4 fmol/mg protein, The proportion of oestrogen receptor‐positive tumours was significantly greater in adenocarcinomas of the cervix than in squamous carcinomas of the cervix. Tissues from 3 mixed mesodermal tumours of the uterus, 2 carcinomas of the vagina, a carcinoma in situ of the cervix and a carcinoma in situ of the endometrium were receptor‐negative. One ovarian carcinoma and a single case of uterine sarcoma were receptor‐positive. The implications of these findings in relation to hormonal therapies are discussed.