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Overexpression of CYP3A aggravates endotoxin‐induced liver injury in hypophysectomized female rats

Aim:  CYP3A2 is a male‐specific isoform of cytochrome P450 enzyme which is expressed abundantly in male rats but not in intact female rats. Having previously reported that hepatic CYP3A2 promotes lipopolysaccharide (LPS)‐induced liver injury in male rats, we further examined the impact of CYP3A on LPS‐induced liver injury by comparing intact and hypophysectomized female rats. In hypophysectomized female rats, phenobarbital (PB), a cytochrome P450 inducer, markedly increased the hepatic content and activity of CYP3A1/2, but did not do so in intact rats. CYP2B1 increased to similar levels in PB‐treated hypophysectomized and intact rats.