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Leopard-Spot Subretinal Deposits in Central Serous Chorioretinopathy.

Leopard-Spot Subretinal Deposits in Central Serous Chorioretinopathy Central serous chorioretinopathy (CSC) is a common disease characterized by acquired retinal pigment epithelium (RPE) abnormalities with multiple leaking points and detachments of the neurosensory retina.1 Besides, a peculiar type of subretinal deposits producing a leopard-spot pattern has been described in chronic CSC as a yellowish orange material.2 However, to the best of our knowledge, optical coherence tomography (OCT) showing the location and shape of these deposits is still not available, even if previously presented.3 Here, we report the peculiar features on multimodal imaging of these leopard-spot deposits, which included embedment at the photoreceptors over an area of neurosensory detachment. These features may help to distinguish them from different leopard-spot patterns raising suspicion of other diseases such as primary vitreoretinal lymphoma, where the infiltration causing this pattern often lays at the level of the RPE.4 This was the case of a 42-year-old woman affected by chronic CSC complicated by bilateral, inferior, exudative retinal detachment. Funduscopic examination revealed yellowish subretinal leopard-spot deposits with a reticular configuration in the left eye, and their multimodal imaging is reported in Figure 1. These deposits were different from other signatures described in chronic CSC, such as catenary forms, leaking sites, or scattered hyperautofluorescence after resorption of serous detachments1,5; although these abnormalities were attributed to RPE defects and irregularities, the present findings were deposits over an intact RPE.1,5 However, unlike from other deposits occurring in CSC, these showed a peculiar arrangement producing a leopard-spot appearance. To conclude, the leopard-spot deposits of this case of chronic CSC were localized between the ellipsoid zone and the RPE over an area of neurosensory detachment and corresponded to subretinal material, which reabsorbed during the follow-up (Figure 2). The recognition of this pattern on multimodal imaging may serve as a clue of severe chronic CSC.