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hZIP1 zinc transporter down‐regulation in prostate cancer involves the overexpression of ras responsive element binding protein‐1 (RREB‐1)

A marked decrease in the level of zinc is a consistent characteristic of prostate cancer; which results from down‐regulation of ZIP1 zinc transporter. The aim of this study was to determine if RREB‐1 transcription is involved in the down‐regulation of ZIP1 gene expression; and to determine the expression of RREB‐1 in benign and cancerous prostate in situ.