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COMPARATIVE ANALYSIS OF LYMPHOCYTE LOCOMOTION IN THE DEVELOPMENT OF DIFFERENT FORMS OF LYMPHOBLASTIC LEUKEMIA

The data about cells locomotion properties in the development of lymphoblastic leukemia was obtained, using the method of semicontact AFM-scanning, the algorithms of investigation of lymphocyte structural cytoskeleton elements and migratory activity. The lymphocytes of patients with acute lymphoblastic leukemia (ALL) have irregular cytoplasmic outlines, thin fibrils of cytoskeleton radiating from the nucleus to the edges of the cell and smoothed surface geometry and are characterized by high motility. Locomotors activity of lymphocytes of patients with chronic lymphoblastic leukemia (CLL) defined by the wavy surface and tight fibril bundles in the nucleus area is decreased, which can lead to the changes of microrheological blood properties.