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Assignment1 of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids

Human liver-specific transport protein (SLC22A7) is a putative organic anion transporter preferentially expressed in the liver. Since SLC22A7 shares a low degree of homology with type I facilitated transporters, it may represent a new member of a separate subgroup of membrane transporters (Simonson et al., 1994). Organic anions seem to be possible substrates for SLC22A7 (Frimmer and Ziegler, 1988). We have isolated a cDNA clone in large-scale cDNA sequencing of a human liver cDNA library. This clone was found to encode a human homolog of rat liver-specific transport protein, and it shares approximately 84% similarity with the DNA sequence of rat liver-specific transport protein which has been reported previously (Accession No. L27651; Simonson et al., 1994). The full length DNA sequence encoding human liver-specific transport protein (SLC22A7) was reported by Kim et al. and was deposited in GenBank with the Accession no. AF097518. This report describes the chromosomal localization of SLC22A7 using radiation hybrids.