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Endometriosis-related ceRNA network to identify predictive biomarkers of endometrial receptivity.

AIM
As RNA, which plays a role in the regulation of endometrial receptivity, can be modulated via ceRNA mechanisms, we constructed a ceRNA network to explore potential RNA/ceRNA biomarkers indicating endometrial receptivity associated with endometriosis.


MATERIALS & METHODS
RNA sequencing was performed on eutopic endometrium from eight patients with and without endometriosis. Bioinformatics algorithms were used to predict ceRNA network and pathway analysis.


RESULTS
We identified an endometriosis-associated ceRNA network involving 45 pathways and four ceRNAs as potential predictive biomarkers for endometrial receptivity. Patients with endometriosis presented lower levels of progesterone receptor type B expression.


CONCLUSION
Differentially expressed RNAs and lower progesterone receptors type B levels in endometriosis might be related to the impairment of endometrial receptivity.