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Gynecologic Operative Experience in Women Exposed to DES in Utero

A review of 309 women exposed to DES in utero revealed 43 major gynecologic procedures, excluding cesarean section, in 33 women (11%) with a mean age of 24.3 years. Pelvic adhesions (54%), ovarian cysts (36%), and ectopic pregnancies (21%) were the major operative findings; no invasive gynecologic malignancies were identified. Eight of the women required at least one additional operative procedure, primarily for pelvic adhesions. In those with DES-related cervicovaginal changes, the incidence of operative procedures was 23%. New problems associated with in utero DES exposure continue to be revealed as affected progeny are studied in more detail. These findings suggest an additional probleman increased incidence of clinically evident adnexal disease involving adhesions, benign ovarian cysts, and ectopic pregnancies