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Blunted muscle mitochondrial responses to exercise training in older adults with HIV.

BACKGROUND
Muscle mitochondrial dysfunction associated with HIV and antiretroviral therapy (ART) may improve with exercise.


METHODS
Muscle specimens obtained before and after 24 weeks of exercise in older PWH (n=18; ART >2 years) and uninfected controls (n=21) were analyzed for citrate synthase (CS) activity and complexes (C) I-V, manganese superoxide dismutase (MnSOD), peroxisome proliferator-activated receptor-γ coactivator-1 (PGC1α), and voltage-dependent anion channel 1 (VDAC1) content.


RESULTS
Only controls had increased CS, MnSOD, PGC1 and CIV (P≤0.01; P< 0.01 vs PWH) after training.


CONCLUSIONS
The blunted mitochondrial adaptations to training in PWH suggests the need for different types of exercise-induced stimulation.