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Comparative study of Rb1, cyclin D1 and p16 immunohistochemistry expression to distinguish lung small‐cell carcinoma and large‐cell neuroendocrine carcinoma

Large‐cell neuroendocrine carcinoma (LCNEC) and small‐cell carcinoma (SCLC) of lung encompass high‐grade neuroendocrine tumour category and share several fundamental features. As both tumours may respond to different treatment modalities and show unique molecular alterations distinction between the two is clinically relevant, but can be challenging due to sampling and fixation issues and shared morphological features.