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Rapid Detection of Insulin-Like Growth Factor-Binding Protein-1 and Foetal Fibronectin in Cervico-Vaginal Secretions to Diagnose Premature Membrane Rupture

Premature rupture of the membranes (PROM), i.e., before the onset of labour, places the mother and foetus at an increased risk of morbidity and mortality if it occurs before 37 weeks of gestation. The diagnosis is usually simple. However, to identify occult rupture, biochemical methods such as the nitrazine test and the detection of diamine oxidase (DAO) or iX-fetoprotein in vaginal secretions have been developed. I These methods must be done in specialized laboratories, and the results are difficult to interpret when the sample is contaminated by blood or topical agents. In addition, both methods lack sensitivity and specificity." Detection of proteins derived from amniotic fluid or the foetal membranes has recently been proposed in this setting. We compared the diagnostic value of two of these proteins, foetal fibronectin (FFN) and insulin-like growth factor-binding protein-I (IGFBP-I), with that of DAO as markers of PROM.3.4