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Single‐ and Repeated‐dose Local Toxicity in the Nasal Cavity of Rabbits after Intranasal Administration of Different Glycols for Formulations Containing Benzodiazepines

To furnish a systemic effect after intranasal administration, a formulation must contain the therapeutic dose in no more than 150 μL, the maximum volume that can be applied as a single administration in one nostril in man. The objectives of these studies were to examine the local toxicity of formulations containing benzodiazepines and to document the effects to support clinical trials in man.