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Severe Burn and Disuse Independently Contribute to Reduction in Bone Density in Rats

Patients with severe burns decrease bone mineral density (BMD). The decrease in BMD may be related to the whole‐body response to injury or bedrest (inactivity). In male rats, we evaluated these factors independently and in combination. Sprague‐Dawley rats (∼300g) were assigned to Sham‐burned/Ambulatory (SA; N=10), Sham‐burned/Hindlimb Suspended (SH; N=10), Burn/Ambulatory (BA; N=9), Burn/Hindlimb Suspended (BH; N=10). Burn groups received a 40% TBSA full‐thickness scald and disuse by hindlimb suspension was initiated immediately following burn. Food intake and urine was measured daily. Total mineral intake and urinary excretion (calcium (C), phosphate (P) and magnesium (M)) were measured for 14 days after injury. BMD was measured using DEXA on day 14. No differences were observed in total mineral (C, P and M) intake when adjusted for body weight. No differences in total urinary excretion in C or M, but significant increases were observed in P comparing BH to SA and SH (p<0.001) as well as BA and SA (p<0.02). Significant differences (p<0.002) in BMD were found between SH and BH when compared to SA and between BA and BH (Mean±SEM (g/cm): SA, 0.159±0.001; BA, 0.155±0.002; SH, 0.152±0.002; BH, 0.149±0.001). Burn and disuse were found to be independent contributors to BMD, however the primary cause is disuse. Support: US Army MRMC & Juvenile Diabetes Foundation