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Ultrafine particulate matter exposure attenuates mouse aortic relaxations

Particulate air pollution (PM) contributes to adverse cardiovascular events by yet unknown mechanisms. We tested the hypothesis that PM exposure altered endothelial regulation of systemic vascular tone. 6–10 week old male ICR mice were exposed to a single dose of 10, 30 or 100 μg of ultrafine PM or vehicle by intratracheal instillation. 24 hours later aortas were isolated and exposed to phenylephrine (PE), acetylcholine (ACH) or adenosine to probe their vascular responses. Constrictor responses to PE were not different between PM exposed and control aortas. PM exposure attenuated ACH relaxation in a dose‐dependent manner.