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The coupling between neuronal activity and blood flow – What can we learn about glaucoma?

The coupling between neural activity and blood flow is an essential physiological mechanism to assure constant supply of the tissue with oxygen and nutrients. Although the exact molecular mechanisms are currently still focus of research, it has been shown that several ocular diseases are accompanied by a breakdown of neuro‐vascular coupling. As such, it has been shown that in patients with early stage glaucoma, the hyperemic response to visual stimulation is reduced. The talk aims to summarize our current knowledge on the physiological importance of neuro‐vascular coupling. In addition, the potential underlying physiological mechanism will be covered. Finally the role of neuro‐vascular coupling and its potential application in the diagnosis and follow up in neuro‐degenerative diseases such as glaucoma will be discussed.