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Insulin-producing cells are bi-potential and differentiatorsprior to proliferation in early human development.

AIM
To investigate the differentiation and migration of endocrine cells to form the pancreatic islets of Langer-hans in early human development.


METHODS
Embryonic pancreas of 6-14 wk gestation was observed using immunocytochemistry methods in early human development.


RESULTS
Insulin and glucagon are expressed in the same epithelium cells in the pancreas. In addition, in-sulin-producing cells also secrete somatostatin in early human embryonic development and these insulin-pro-ducing cells also express nestin.


CONCLUSION
Pancreatic duct epithelial cells that can produce insulin in early human development are pre-cursors and still have the potential to differentiate other endocrine cells. These progenitors have differen-tiated before migration from primary ductal epithelium to form the pancreatic islets.