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[Study on the presence of hepatitis B virus in first-trimester villi in pregnant women with hepatitis B surface antigen positive].

OBJECTIVE
To observe the presence of hepatitis B virus (HBV) in first-trimester villi cells from pregnant women carrying HBsAg.


METHODS
Immunohistochemical streptavidin-biotin peroxidase complex (SABC) staining with monoclonal HBsAg, hepatitis B core antigen (HBcAg) and PCR, in situ hybridization were used for detection of HBV infection markers in villi. Positive villi ultramicrostructures were observed with transmission electron microscope.


RESULTS
HBV was detected in 8 of 25 villi of HBsAg positive pregnant women, the positive rate was 32%. HBsAg was located in the decidual cell, trophoblastic cell and villous mesenchymal cell. HBV analog was detected in rough endoplasmic reticulum of trophoblastic cell.


CONCLUSIONS
HBV may infect villous cells in first-trimester pregnancy. It would be impossible for HBV to transmit the desmosomes.