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The Effect of Caffeine and 1976T>C (ADORA2A) Genetic Variants on Anaerobic Performance during a 30‐Second Wingate Test

The supplementation of caffeine is often used to elicit an enhancement of focus, arousal, or performance; however, intra‐individual response to caffeine has been shown to vary the effects of caffeine. Genetic variation of the adenosine receptor, 1976T>C (ADORA2A), has been linked to caffeine sensitivity and is a potential target for understanding individual differences. The TT genotype demonstrates an increased sensitivity to caffeine compared to the TC/CC genotype. The anxiogenic effects, genetic influences, and pharmacological interactions play a role in the ergogenic effects of caffeine.