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Hypouricaemic effect after oral administration in chickens of polyethylene glycol‐modified uricase entrapped in liposomes

Liposomal‐entrapped methoxypolyethyleneglycol (PEG) modified uricase was used to study the plasma urate lowering effect after its oral administration to chickens. Plasma uric acid concentrations fell gradually and were accompanied by a rise in plasma uricolytic activity. Serum from chickens given PEG‐modified uricase liposomes did not react with native uricase in immunodiffusion plates. These results suggested the clinical usefulness of liposome‐entrapped PEG modified uricase in the treatment of hyperuricaemia.