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Effects of soy and tea on hormone‐induced prostate cancer in Noble rat model

Chronic inflammation and NFκB have been implicated in prostate cancer development; thus, dietary factors that inhibit NFκB may serve as effective chemo‐preventative agents. Prostate cancer risk is significantly lower in Asian countries compared to the US, which has prompted the interest in the potential chemopreventative action of Asian diets. This study examines the effects of dietary soy and tea on the NFκB activation, inflammation and tumor development in vivo using a hormone‐induced rat model for prostate cancer. Male Noble rats implanted with estradiol and testosterone were divided into 4 dietary groups: control, soy, tea, or soy+tea diet. NFκB activity and inflammatory cytokines were measured post implantation. At 20 and 38 wk post‐implantation, prostate hyperplasia and prostatic intraepithelial neoplasia (PIN) were also assessed. The combination of soy and tea suppressed NFκB p50 binding activity and decreased NFκB p65 and p50 protein levels via induction of IκBα. Soy and tea also decreased prostate hyperplasia, increased Bax expression, and decreased gene expression of IL6 and IL1β compared to control. These effects were not apparent in groups treated with soy or tea alone. The ongoing in vivo studies thus far suggest that combination of foods, like soy and tea, may inhibit hormone‐induced pro‐inflammatory NFκB signals that contribute to prostate cancer development.