{'fraction_non_alphanumeric': 0.021723896285914507, 'fraction_numerical': 0.01051156271899089, 'mean_word_length': 4.6, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Contrasts in antidepressant medications.

Abstract 
1 Two studies are reviewed, one in depressed patients, the other in healthy volunteers. 
 
2 The effect of nomifensine and imipramine on depressed out-patients has been studied in a controlled double-blind manner. Treatment lasted for 4 weeks and assessments were carried out before and at weekly intervals during the study. These involved use of a self-rating scale and four observer rating scales. 
 
3 In the self-rating scale, 13 of the 14 discriminating items favoured nomifensine, and indicated that it possessed a strengthening or energizing activity, and analysis of individual items on the Hamilton Depression Scale confirmed this. 
 
4 In this study, imipramine showed greater effect on mood and on sleep disturbances. 
 
5 A comparison of nomifensine, imipramine and placebo was carried out in 90 volunteers in a double-blind randomized study. Each volunteer received three doses of medication during the study day. 
 
6 The assessments include a Digit Symbol Substitution Test, the production of a temporal interval, and a simple and a complex test of attention or vigilance. 
 
7 The influence of nomifensine on these tests could not be distinguished from that of placebo. There was evidence, however, that imipramine depressed performance and possessed a sedative effect. 
 
8 The results of both studies, when considered together, are essentially in agreement.