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P12.09: Hypoplastic left heart syndrome and fetal valvuloplasty in Mexico

the uterine, umbilical and fetal middle cerebral artery pulsatility index (PI) in the first 48 hours of tocolysis. Methods: This was a prospective observational study performed in 32 subjects admitted at the Intensive Maternal Unit ward for control of preterm labour with nifedipine from Feb. 21, 2011-June 15, 2011. Dopplers using PI of the uterine (Ut), umbilical (Umb), fetal middle cerebral artery (MCA), cerebroplacental ratio (CPR), maternal blood pressure (BP), heart rate (HR), chest findings, fetal heart rate (FHR) with M mode were performed before 0 hour, within 5th hour, 24th hour and 48th hour after loading dose of nifedipine tab 30 mg PO and maintenance dose of 10 mg tab every 4 hours. Results: 32 patients completed the study. Mean age of the patients was 25.8 years. Most were G1 and G2 comprising 31.2% with a gestational age (GA) of 31 weeks. Cervical dilatation on admission was 1.4 cm. 2 subjects delivered after 24 hours with a GA of 32 weeks, BW of 1600 grams and an apgar score of 9,9. There were no fetal deaths, respiratory failures or any adverse events in the neonates. After giving the loading and maintenance doses of nifedipine, there were no significant effects on the BP, maternal HR and FHR within the 5th hour, 24th hour and 48th hour. The mean PI values for the Ut, Umb, MCA and CPR with nifedipine within 5th hour, 24th hour and 48th hour when compared with the values prior to administration (0 hour) showed no significant differences in the mean PIs of the Ut (right P = 0.990; left P = 0.705) and Umb (P = 0.688) arteries and MCA (P = 0.825) or in the CP ratio (P = 0.817). Conclusions: Oral Nifedipine as a tocolytic with a standard regimen of 30 mg tablet loading dose and 10mg tablet every 4 hours maintenance dose used in normotensive pregnant women has no significant effects in the maternal and fetal hemodynamics.