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Pharmacological Inhibition of the hERG Potassium Channel Is Modulated by Extracellular But Not Intracellular Acidosis

Acidosis and hERG K+ Channel Pharmacology.  Introduction: Human Ether‐à‐go‐go related gene (hERG) is responsible for channels that mediate the rapid delayed rectifier K+ channel current (IKr), which participates in repolarization of the ventricles and is a target for some antiarrhythmic drugs. Acidosis occurs in the heart in some pathological situations and can modify the function and responses to drugs of ion channels. The aim of this study was to determine the effects of extracellular and intracellular acidosis on the potency of hERG channel current (IhERG) inhibition by the antiarrhythmic agents dofetilide, flecainide, and amiodarone at 37 °C.