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Prognostic impact of cytogenetic abnormalities in children and adolescents with mature B‐cell non‐Hodgkin lymphoma: A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)

Little information is available on cytogenetic abnormalities and their prognostic importance in childhood mature B‐cell non‐Hodgkin lymphoma (B‐NHL). We performed a review of 79 abnormal karyotypes in childhood B‐NHL treated by a uniform protocol. Del(17p) was independently associated with significantly inferior event‐free survival in Burkitt or Burkitt‐like lymphoma. The adverse prognosis of MYC/8q24 rearrangement, +7q or del(13q), was not observed, which had been suggested as risk factors in FAB/LMB96. Our results imply the possible existence of a biological difference among ethnicities and should be useful to narrow down the gene causing poor prognosis in childhood B‐NHL. Pediatr Blood Cancer 2015;62:1294–1296. © 2015 Wiley Periodicals, Inc.