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The Role of Matrix Metalloproteinase-1 and Tissue Inhibitory Matrix Metalloproteinases-3 in the Case of Bladder Neck Contracture Post Transurethral Resection of Prostate

The pathogenesis fibrosis mechanism post transurethral resection of prostate (TURP) from Bladder neck contracture (BNC) still not clear yet. Fibrosis post the wound healing is occurred by imbalanced result of breakage of extracellular matrix (ECM) by matrix metalloproteinases (MMPs). The tissue inhibitory matrix metalloproteinases (TIMPs) inhibited MMPs activity. MMP 1 and TIMP 3 play important role in the remodeling phase of wound. Aim of study to investigate role of MMP 1 and TIMP 3 in accordance to the fibrosis density on BNC post TURP. The BNC patients post TURP from M. Djamil Hospital Padang was collected. Expression of MMP 1 and TIMP 3 were measured by immunohistochemistry and fibrosis density was examined by histopathology. The 75 % of samples have medium fibrosis density, 15 % in the mild level and 10% in the severe level. The MMP1 expression was 27,50 % (±15,67) and TIMP3 was 24,94% (±17,33). The correlation of expression MMP1 and fibrosis density were mildmedium with R=0,25 and positive directional correlation P>0,0. TIMP3 related to fibrosis density with P<0,05 and positive directional correlation.In conclusion, TIMP3 plays significant role in fibrosis density toward BNC with positive directional correlation in post TURP.