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BLT1 signaling in epithelial cells mediates allergic sensitization via promotion of IL‐33 production

Epithelial cells (ECs) play a crucial role in allergic sensitization to inhaled protease allergens by instructing type 2 innate lymphoid cells (ILC2) and dendritic cells (DCs) via release of pro‐type 2 cytokines, particularly interleukin‐33 (IL‐33). Leukotriene B4 (LTB4) is a well‐known leukocyte chemoattractant via engagement of its receptor 1 (BLT1). However, the role of LTB4‐BLT1 axis in allergic sensitization via activation of ECs is still unknown.