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Metabolism of 131I‐Chinoform in the Rats Treated with Carbon Tetrachloride

INTRODUCTION In a previous paper”) we reported our study about chinoform metabolism by using labelled chinoform. The results then have revealed that the major portion of chinoform is excreted into urine in the form of glucuronic acid conjugate. Therefore, in order to maintain the toxicity of chinoform in vivo, it is necessary to increase the amount of free chinoform in the body. As a step towards this purpose the administration of carbon tetrachloride into rats would be feasible. It can be assumed that in the carbon tetrachloride-induced fattey liver as a result of liver disturbances the conjugating ability of glucuronic acid is decreased (a decrease of activated glucuronic acid) and glucuronic acid bound chinoform decreases but free chinoform increases. In the present study we induced carbon tetrachloride fatty liver in rats and then injected intravenously 1311-chinoform to these animals to determine whether or not the ratio of free chinoform to conjugate chinonorm would increase. The results are presented as follows.