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Extreme elevation of transcobalamin II levels in multiple myeloma and other disorders.

The source of transcobalamin (TC) II in man and the factors controlling its serum level are unknown. We studied 98 patients with extreme elevation of this protein (>2000 ng/Iiter, a level approximately twice normal mean), grouped by predominant diagnosis in the categories of liver disease (primarily alcoholic cirrhosis) (17 patients), infection and other inflammatory disorders (21), cancer (17), lymphoproliferative disorders (9), and, most interestingly, multiple myeloma and related disorders (25); the remaining patients had miscellaneous disorders. Although many patients had persistent IC II elevation, in