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Urinary Catecholamine Excretion by Various Age Groups with Special Reference to Clinical Value of Measuring Catecholamines in Newborns

Summary: The sympatho-adrenal system function was assessed in various age groups of normal subjects and in infants with abnormal conditions by assays of daily urinary catecholamine excretion. The daily urinary catecholamine excretion was prone to increase postnatally with time. The group of infants aged 1–5 years exhibited a significantly greater urinary catecholamine excretion than the 0–1-year-age group. No significant difference was observed between the 1–5-year-old and 6–10-year-old age groups in urinary catecholamine excretion. Nor did urinary catecholamine excretion differ significantly between the 11–20 and 6–10-year-old age groups. The values found for daily urinary catecholamine excretion in seven successive age groups of 10-year intervals from 11–80 years showed noticeable inter-subject variation with no significant intergroup differences. These age-related changes in levels of urinary catecholamines from birth to senility indicate a developmental process of the sympatho-adrenal system.Urinary catecholamine excretions were also measured in infants in special clinical conditions to evaluate the clinical validity of the assay during the neonatal period. The present data indicate that the assay of urinary catecholamine excretion constitutes a useful tool for delineating the clinical features as well as for following up the clinical progress in newborn infants. The present communication is the first to demonstrate the usefulness of urinary catecholamine determination in newborn infants.Age related changes in levels of urinary catecholamines from birth to senility would indicate developmental process of the sympathoadrenal system. In addition, our results suggest that the measurement of urinary catecholamine excretion acquires a great importance as a parameter for delineating the distressed condition as well as for following up the clinical features of newborn infants.