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Clinical trials in sepsis.

Sepsis is an increasing and major healthcare problem worldwide.1 Using data from 91 intensive care units (ICUs) collected between 1995 and 2000, there were estimated to be 51 cases of severe sepsis per 100,000 population in England, Wales and Northern Ireland over this period.2 It was also reported that 27% of all admissions to critical care suffered from severe sepsis within the first 24 hours. There was 47% hospital mortality among these patients and they occupied 45% of total hospital critical care bed-days. The incidence of sepsis also appears to be increasing: there has been a 53% increase in the UK between 1996–1997 and 2001–2002.3