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Evidence of absorption of bromsulphthalein from the biliary system of the rat

Many drugs and their metabolites are excreted in the bile (Smith, 1966), but it remains unclear which factors are involved in the bile elimination of these compounds. It has been suggested that the bile during its passage through the biliary tract may be altered to some extent by reabsorption and secretion of water and solutes (Andrews, 1955; Brauer, 1959; Sperber, 1959; Goldfarb, Singer & Popper, 1963; Wheeler, 1968). Furthermore a reabsorption and secretion of some organic compounds in the biliary tract has also been suggested (Clark, Hirom & others, 1971). These authors have investigated the biliary absorption from the biliary tree in the rat given different organic compounds by retrograde biliary injection. According to their results, compounds with low molecular weights (179-285) were poorly excreted by bile after intravenous infusion and retrograde injection whereas compounds with higher molecular weights (335-752) were excreted in high amounts under these conditions. Furthermore, the compounds of the latter group showed a slowly increasing biliary excretion after retrograde injection. The authors therefore supposed that some absorption from the biliary system followed by excretion may occur in the group with higher molecular weight. To test this hypothesis we have investigated the biliary excretion of bromsulphthalein (BSP) in the rat giving this compound by intravenous and by retrograde biliary administration. BSP is excreted about 85 % after intravenous and about 81 % after retrograde biliary administration. In the latter instance the biliary excretion slowly increases indicating that this effect is possibly preceded by some absorption of BSP within the biliary tree. By thin-layer chromatography it was possible to show that after retrograde administration a metabolic transformation of BSP took place. Qualitatively there was no difference in the number of BSP metabolites found in the bile after intravenous infusion or retrograde administration. To exclude the possible transformation of BSP by bile we incubated comparable doses of BSP with bile. No BSP metabolite could be detected by these in vitro experiments which could be interpreted in the sense that BSP must enter the hepatocytes before the metabolic transformation could occur. The results of these experiments are shown in Table 1 . J