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Characterization of μ‐Opiate Receptor in Human Epidermis and Keratinocytes

Recent studies suggest that the nervous system and the skin interact directly through neuropeptides. 1 Neuropeptides are able to interact with multiple types of cells in the skin in order to mediate actions that are important in skin inflammation. Thus, there is possibly, not only a neuroimmunologic axis, but also a neuroimmune– dermatologic axis. There is increasing evidence that neurotransmitters play a crucial role in skin physiology and pathology. The expression and production of proopiomelanocortin (POMC) molecules, such as β -endorphin, in the human epidermis 2