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Interpretation of Lamellar Electron Diffraction Data from Phospholipids

Lamellar electron diffraction intensity data from a series of optically active 1,2-diradyl phosphatidylethanolamines were used to determine the probable crystal packing, based on translational fitting of the molecular conformation found in the x-ray crystal structure of a dilauroyl homolog. All crystal structures are shown to be similar to one another. A packing model similar to that found from the analysis of lamellar x-ray data from the dimyristoyl homolog is obtained when the measured electron diffraction data are corrected for the curvilinear lamellar deformations seen in direct low dose lattice images.