{'fraction_non_alphanumeric': 0.02490566037735849, 'fraction_numerical': 0.009056603773584906, 'mean_word_length': 5.978947368421053, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
An emerging dual collaborative strategy for high-performance tumor therapy with mesoporous silica nanotubes loaded with Mn3O4.

A highly integrated nanocomposite is constructed based on mesoporous silica nanotubes (SiNTs)-loaded with Mn3O4 nanoparticles for cervical cancer therapy via T1-weighted magnetic resonance imaging and doxorubicin-based chemotherapy. Mn3O4 magnetic nanoparticles uniformly distributed within SiNTs can effectively detect the tumor microenvironment, as revealed by clinical T1-weighted magnetic resonance imaging. The SiNTs possessed a high loading rate for doxorubicin (DOX) and a simultaneous pH-dependent response release, mainly due to the electrostatic interaction between DOX molecules and the mesoporous silica surface. According to MTT assay, confocal laser scanning microscopy and bio-TEM observations, the cellular uptake of the as-prepared DOX-Mn3O4-SiNTs was both dose- and time-dependent, and the SiNTs were accumulated mostly in lysosomes. Further pathological examinations revealed that the DOX-Mn3O4-SiNTs multifunctional drug delivery system led to remarkably destructed cells, large vacuoles, and irregular widening of tumor tissues. This collaborative strategy could pave the way towards high-performance nanotherapeutics with superior antitumor efficacy and reduced side effects.