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Variability of Postsynaptic Responses Depends on the Number of Synaptic Inputs

A conductance-based model for synaptic transmission and postsynaptic integration reveals that the variability of postsynaptic responses depends on the number of synaptic inputs in a non-linear way. Increasing the number of excitatory and inhibitory inputs increases the total synaptic conductance. In consequence, the total excitatory and inhibitory currents become anti-correlated although the individual inputs vary independently from each other and the resulting membrane potential stays close to the resting potential. The postsynaptic variability is determined by the interacting effects of increasingly more independent inputs and the anti-correlation of the excitatory and inhibitory currents. These findings lead to an intuitive explanation why correlated inputs can increase the variability of neuronal responses.