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Functional Status of Mitochondrial Pore in the Brain of Laboratory Rats Subjected to Prolonged Emotional Stress

We have studied the functional status of the mitochondrial membrane pore in the brain of laboratory rats under the stress caused by 30-day isolation and violation of diurnal cycles. It has been established that the functional status of the MMTP changes under the stress. Particularly, the MPTP is activated as the pore opens affected by an increased concentration of cytoplasmic Са2+ and reduced content of mitochondrial Са2+. It has been suggested that the Са2+-induced opening of the pore is a result of the intensified oxidative processes in the brain, as a result of energy deficiency and a reduced activity of anti-oxidative enzymes.