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Acute systemic hypoxia and the surface ultrastructure and morphological characteristics of rat leucocytes

We have examined the surface ultrastructure and morphological characteristics of leucocytes obtained from control rats breathing air and rats made acutely hypoxic (breathing 6% O2, for 30 min). Striking ultrastructural and morphological changes occurred in the leucocytes of hypoxic rats. These changes included the appearance of crater‐like holes, a reduction in granule size and disruption of the cell membrane. The implications of these findings are discussed.