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Prognostic value of Ki67: comparison of the proliferation index between meningiomas with and without infiltration of glial tissue.

BACKGROUND
Although generally considered benign, meningiomas can cause significant morbidity and mortality.  Histologic grade is the most useful morphologic predictor of recurrence.


OBJECTIVES
To compare Ki67 labeling index between meningioma grade I and meningioma grade II with brain invasion.


METHODS
We analyzed 20 primary meningioma, 10 of which were grade I and 10 of which were grade II. Ki67 proliferative indices were determined in all cases.


RESULTS
The patient population consisted of 9 males and 11 females with mean age of 60 years. For meningioma grade I, the Ki67 labeling index varied between 1 and 15% with an average of 3.1%. A diagnosis of gradeII meningiomas was made solely on the basis of brain invasion. The immunohistochemical study noted that the Ki67 index varied between 1 and 20% with an average of 6,8%.


CONCLUSION
The Ki67 labeling index shows a significant increase from grade I to grade II.  It may provide useful prognostic information.