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Hemorrhagic Cellulitis and Osteomyelitis Secondary to Ibrutinib Therapy.

In this case, dopaminergic and 5-HT2 receptor blockade may have played a role in producing peripheral edema. Thus, the possible progression of peripheral edema should be considered in patients receiving clothiapine. Selecting another antipsychotic agent with different pharmacodynamics may suspend the edematous reaction. Future studies should clarify the dose-dependent effects of clothiapine-associated edema and differentiate potential pathogenic roles of the varying forms of clothiapine.