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Effects of [1-(3-mercaptopropanoic acid)]-vasopressin and -vasotocin on the pro-oestrous progesterone surge and ovulation in immature female rats.

The desamino analogues of arginine-vasotocin (dAVT) and arginine-vasopressin (dAVP), when administered on the afternoon of pro-oestrus to immature female rats primed with pregnant mare serum, blocked the preovulatory progesterone surge and inhibited ovulation. Statistical analysis revealed no difference in the potency of the two compounds. At a dosage of 2.0 micrograms, dAVT and dAVP yielded a 70 and 87% block of ovulation respectively. Simultaneous administration of dAVT and the antipressor compound [1-deaminopenicillamine-4-valine-8-D-arginine]-vasopressin had no statistically significant inhibitory effect when compared with saline-treated controls. These data suggest that the inhibitory effects of dAVT and dAVP on the progesterone surge and subsequent ovulation are mediated through receptor sites similar to those mediating the pressor actions of the parent hormones.