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Immunoregulation in multiple sclerosis

Over the past several years, studies emanating from many different laboratories have documented that something is awry with immune regulation in multiple sclerosis (MS). Since most current thinking holds that multiple sclerosis will likely prove to be an autoimmune process, possibly triggered by an infectious event, a careful exploration of immune regulation in multiple sclerosis may be directly relevant to the pathogenesis of the disease. In keeping with the past history of multiple sclerosis research, there remains a substantial disagreement as to the nature, magnitude, and underlying significance of aberrancies in immune regulation in multiple sclerosis. The discussion that follows attempts to consider these matters in a general way, but it should be recognized that some of the opinions to be expressed are those of the authors and may not be generally agreed upon by workers in the field.