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Beneficial role of l‐arginine in cardiac matrix remodelling in insulin resistant rats

Background  The study was performed to determine whether sucrose‐induced insulin resistance could increase the expression of cardiac matrix metalloproteinases (MMPs), indices of matrix remodelling, and whether the addition of 1·25 g die−1 of L‐arginine (ARG) to a sucrose diet could prevent both the sucrose‐induced metabolic abnormalities and elevated cardiac expression of matrix metalloproteinases in an insulin resistant stage that precedes frank type 2 diabetes.