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Response by Gutiérrez et al to Letter Regarding Article, "Hemoglobin Concentration and Risk of Incident Stroke in Community-Living Adults".

Drs Yang, Li, and Zeng have raised several concerns about the interpretation of the association of hemoglobin with stroke risk in the REGARDS study (Reasons for Geographic and Racial Differences in Stroke). Although we appreciate their interest in our study, we think that the crux of their concerns is based on a misapplication of data from prior studies to our own study. The primary focus of our study was to examine the association of hemoglobin with future risk of incident stroke in community-dwelling adults. In contrast, the 2 comparator studies cited by Drs Yang, Li, and Zeng focused on the association of hemoglobin at the time of acute stroke hospitalization with poststroke outcomes (functional outcome, mortality, etc).1,2 We fully agree that determining the association of hemoglobin with …