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Coupled simulation of human circulatory, thermoregulatory and renal systems

Presents a new lumped-parameter model-based simulation of coupled human circulatory, thermoregulatory and renal systems. The coupled analysis captures the dynamic interaction of these three human physiological systems even though simple models are used. These coupled dynamics have never been studied before, even though subsystem models have existed for some time. The simulation shows how the thermal excitation and body salt and water intake influence the circulatory system. Each subsystem is modeled in the form of an ordinary differential equation. The individual models are appropriately simplified according to the simulation parameters after they have been assembled into a coupled system. The resulting coupled system equation is in the form of a differential algebraic equation (DAE), which is the standard model representation of the simulation environment we used. The simulation results agree with experiment or predictions based on physiological knowledge.