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[Contractile activities of spastic canine basilar arteries and its surrounding clot (author's transl].

A prolonged vasospasm was produced in the canine basilar artery by administration of fresh autogenous arterial blood into the chiasmatic cistern. Lyophilized homogenates of normal and spastic canine basilar arteries as well as of blood clot around the spastic artery, were made, and their contractile activities were studied with the canine basilar artery in vitro. The lyophilized homogenates of the spastic artery and the blood clot induced a sustained, strong contraction, whereas those of the normal artery produced a transient, slight contraction. The contraction induced by the lyophilized homogenates of spastic artery was reduced slightly by methysergide and greatly by phentolamine. It may be suggested that vasoactive substances are present in the spastic artery as well as in its surrounding clot.