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A comparison of pituitary responsiveness to luteinizing hormone-releasing hormone during lactation and the estrous cycle of the rat.

To determine what role pituitary responsiveness plays in the suppression of gonadotropin secretion during lactation in the rat, three parameters of pituitary responsiveness to LHRH were compared during lactation and the estrous cycle: 1) the magnitude of the response, 2) the duration of the response, and 3) the dose response. Doses of 25,100, or 500 ng of LHRH were administered to animals on diestrus-1 (D-l), diestrus- 2 (D-2), and on days 5, 10, 15, and 20 postpartum. Following each of the three doses of LHRH, dose-dependent peak levels of LH were reached which did not differ in cycling animals and in lactating females nursing either two or eight pups. In all groups of animals, the magnitude of the response following 25 ng LHRH was approximately 50% of that following 500 ng of LHRH. Therefore, pituitary responsiveness to LHRH during lactation is similar to that during diestrus of the cycle, as judged by peak levels of LH reached. Furthermore, since 500 ng of LHRH released significantly more LH in ovariec...