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Proliferation and differentiation of rat dorsal prostatic epithelial cells in collagen gel matrix culture, focusing upon effects of adipocytes

Abstract Background : Prostatic epithelial cells organize functional acinus structures under epithelial– extracellular matrix and epithelial–stromal cell interactions. Recently, the adipose tissue, which surrounds and even exists within the prostate, has been suggested to affect the differentiation and proliferation of some cell types. Therefore, tissue fragments, which consist mainly of epithelial and fibromuscular stromal cells, were cultured in three‐dimensional collagen gel matrix culture with adipocytes.