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Pharmacokinetics of Netilmicin in CAPO Patients

The pharmacokinetics of netilmicin were studied during 16 episodes of peritonitis in CAPD patients. An initial intraperitoneal dose of 10 mg of netilmicin per litre of dialysate gives a concentration adequate for most cases. This dose may have to be increased according to the respective minimal inhibitory concentrations (MICs) of the infecting organisms.