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142 Vascular Endothelial Growth Factor Gene Polymorphism and The Risk of Retinopathy of Prematurity

Background: Vascular endothelial growth factor (VEGF) can play important role in the development of retinopathy of prematurity (ROP). There are interesting observations of VEGF concentration in the serum depending on its gene polymorphism and VEGF gene polymorphism can have an impact on abnormal vessel development in the retina in type II diabetes.Aim: Analysis of association of C(−634)G polymorphism of VEGF gene promotor and the risk of ROP.Methods: A sample of 62 newborns with mean birth weight 1082±32g and mean gestational age 28,3±0,3 wks. was evaluated. The infants were divided into 3 groups: A – no ROP (n=39), B – ROP not requiring treatment (n=10) and C - ROP requiring laser or cryotherapy (n=13). Molecular studies of VEGF polymorphism were performed with PCR-RFLP and RG-PCR methodology.Results: The frequency of each alleles are similar in the studied groups (table).Conclusion: There is no association of C(−634)G polymorphism of VEGF gene promotor and the risk of retinopathy of prematurity.