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[The effect of modification of the intracellular distribution of polyamines on the proliferation of hepatocytes treated with 2-methyl-9-hydroxyellipticine].

2-Methyl-9-hydroxyellipticine (MHE) added to tumoral hepatocyte cultures (400 ng MHE/ml medium) is responsible for a cytostatic effect. This decrease of cellular proliferation and of DNA synthesis is accompanied by an increase of intracellular free spermidine levels. We could not attribute this result to a deviation of this polyamine metabolism. These increased concentrations of free spermidine are connected to a decrease of the amount of nuclear bound polyamines, mainly joined with the RNA fraction. Thus, the cytostatic effect observed with this drug might be related to a decrease in the amount of spermidine connected to RNA; therefore, its intercalating effect is only indirectly responsible for the cellular proliferation decrease.