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Staphylococcus aureus triggers nitric oxide production in human upper airway epithelium

Nitric oxide (NO) is an important antibacterial defense molecule produced by upper airway (sinonasal) epithelial cells. We previously showed that a bitter taste receptor expressed in airway epithelium detects quorum‐sensing molecules secreted by Gram‐negative bacteria and subsequently triggers bactericidal NO production. We hypothesized that the upper airway epithelium may also be able to detect the Gram‐positive aerobe Staphylococcus aureus and mount an NO response.