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VALIDATION OF A MURINE MODEL OF HYPERPLASIA IN COLON


 
 
 New endoscopic technologies developed to improve colorectal cancer diagnosis need to be validated on animal models, which already exist for neoplastic polyps, but not for hyperplasia. For that, a hyperplastic model of growth in colon has been created on murine animal. For its characterization, a first pilot study was performed, and this study aims to validate the results.
 
 
 
 30 Pirc (Polyposis In the Rat Colon) rats, wild type strain (F344/NTac-Apcam1137), were used. The hyperplastic model was induced by laparotomy with a non-resorbable suture, not stenosing, placed through the colon wall. Then, colonic biopsies were extracted weekly from the growth around the suture.
 
 
 
 After the second follow-up, hyperplastic growths are already found. The reproducibility of the model has been obtained and the optimal time determined, after induction of the model. According to our knowledge, this is the first induced colonic hyperplasia model in rats. It solves limitations of other traditional models that only produce hypertrophy, where hyperplasia appears when iatrogenic effects occur as undesired results in a non-standardised or reproducible form.
 
 
 
 This work has successfully developed a preclinical model of colonic hyperplasia in rats that recreates important characteristics of human hyperplasia, such as the generation of new cells in the colonic mucosa and tissue growth, as well as the corresponding angiogenesis. The new hyperplastic model created could be used for the validation of endoscopic technology, and other studies. It would be useful to improve optical biomarkers of colorectal cancer and to discriminate between endoscopic findings.
