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Severe Inhibition of Choroidal Neovascularization in Mice With a Combined Deficiency of MMP-2 and MMP-9 Genes

Time course RN A M T1 -M M P/ 28 S MT1-MMP III. Temporal quantitative RT-PCR Previous studies have shown that the production of gelatinases (MMP-2 and MMP-9) belonging to the matrix metalloproteinase family is increased in human choroidal neovascularization (CNV) occurring during the exudative most aggressive form of agerelated macular degeneration (AMD). To more precisely delineate the respective roles of MMP-2 and MMP-9 in choroidal neoangiogenesis, we investigated their expression and activities in the course of laserinduced murine choroidal neovascularization,. This model was applied to single (MMP-9 KO, MMP2 KO) or double (MMP-2,9 KO) deficient mice and to their corresponding wildtype (WT) controls. RT-PCR evaluation showed that MMP-9 expression was upregulated during early phases of CNV formation, while MMP-2 was constitutively expressed without any transcriptional modulation. Interestingly, MT1-MMP mRNA was concomitantly upregulated suggesting that the presence of active MMP2 forms was due to the expression and activity of its activator.