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Monoclonal macroglobulinemia and cytomegalic inclusion disease.

An 8-month-old infant with cytomegalovirus infection and monoclonal macroglobulinemia is described. The abnormal IgM reached levels of 2,700 to 3,200 mg/100 ml in serum, had no demonstrable antibody activity and contained kappa light chains only. Cytomegalovirus was recovered from throat and urine throughout life and the infant had histopathologic evidence of disseminated cytomegalovirus and pulmonary Pneumocystis carinii infections at postmortem examination. The presence of an underlying defect of the immune system could not be established with certainty. To our knowledge, this is the first documented case of cytomegalovirus infection and monoclonal macroglobulinemia.