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Relationship between mesangial deposition of IgA1 and IgA2 subclasses and complement activation in IgA glomerulonephritis

the first biopsy, mesangial deposition of IgA1, IgA2, C3c, factor B and MBL/MASP-1 was detected in all patients in the second biopsy, but C4 in nine. Four of 15 patients with IgA1 deposits alone in the first biopsy showed mesangial deposition of IgA1, IgA2, C4 and MBL/MASP-1 in the second biopsy. In the remaining 11 patients, immunohistological findings were not different in between the first and the second biopsy. There was no correlation in the clinical outcome and pathological indicators between IgA2-positive and IgA2-negative patients. In conclusion, the relationship between mesangial IgA1 and IgA2 deposition and the activation of the complement pathway is reconfirmed and the association is continuous. In patients with mesangial deposition of both IgA1 and IgA2, IgA2 is subsequently deposited in the mesangium after IgA1 is initially deposited.