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Is Variation in the GABA(B) Receptor 1 Gene Associated with Temporal Lobe Epilepsy?

Summary:  Purpose:γ‐Aminobutyric acid (GABA)‐receptor genes are prime candidates for a role in seizure susceptibility. An association between the c.1465G→A variant in the GABA(B) receptor 1 gene (GABBR1) and susceptibility to temporal lobe epilepsy (TLE) has been reported in an Italian cohort. We sought to replicate this association in an independent Australian cohort.