{'fraction_non_alphanumeric': 0.04066193853427896, 'fraction_numerical': 0.025059101654846337, 'mean_word_length': 5.3927492447129906, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Interaction Effects of Diabetes and Hypertension on Cardio-Cerebrovascular Diseases: A Cross-Sectional Study


 Background It is still not clear whether there exsist interaction effects of diabetes and hypertension on cardio-cerebrovascular diseases. We can not ignore it in order to prevent the incidence and progress of cardio-cerebrovascular diseases considering the high prevalence of diabetes and hypertension in the world.Methods A cross-sectional study with a multistage stratified random sampling method was conducted among people aged 18 years or older in Changsha City, Hunan Province. A multivariate logistic regression model was performed to analyze the association between diabetes complicated with hypertension and cardio-cerebrovascular diseases. The multiplicative interaction effect was evaluated by including the product term of hypertension and diabetes in the model after adjusting for age, sex, smoking, drinking, physical exercise, and body mass index. The relative excess risk ratio (RERI), attribution percentage (AP), synergy index (SI) and 95% confidence interval (CI) were calculated by the Excel calculation table compiled by Andersson to evaluate the additive interaction effects between hypertension and diabetes on cardio-cerebrovascular diseases.Results A total of 14422 participants were recruited. The prevalence of cardio-cerebrovascular diseases in the non-diabetes and non-hypertension, diabetes, hypertension, and diabetes and hypertension combination groups was 3.7%, 12.1%, 21.2% and 31.4%, respectively. The RERI, AP and SI of diabetes combined with hypertension on cardiovascular diseases were 1.92 (95% CI: -2.67 - 6.50), 0.23 (95% CI: -0.22 - 0.68) and 1.34 (95% CI: 0.69 - 2.62), respectively.Conclusions The prevalence of cardio-cerebrovascular diseases in diabetes complicated with hypertension was higher than that in any single condition. However, no interaction effects between diabetes and hypertension were found on the prevalence of cardio-cerebrovascular diseases, indicating that the high prevalence may be due to the simple superposition of the two variables.