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Challenges in Caring for the Neonate Who Acquires Methicillin-Resistant Staphylococcus aureus via Vertical Transmission

Neonates most often present with methicillin-resistant Staphylococcus aureus (MRSA) infections beyond 3 days of age. Infection is usually acquired horizontally from direct contact with a family member or health care personnel who has MRSA colonizing the nares or skin. If the genital tract of a pregnant woman is colonized with MRSA, the infant may acquire the bacterium during labor and delivery. We describe the case of a term infant who likely acquired MRSA colonization via vertical transmission. This report calls attention to the challenges associated with the interpretation of a single blood culture positive for MRSA in such an infant, the treatment of MRSA infections in neonates, and the prevention of future MRSA infections in the mother–infant pair.