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CONTINUOUS USE OF ORAL ANTIBIOTICS IN THE MANAGEMENT OF PATIENTS WITH CYSTIC FIBROSIS

This study was designed to determine the effectiveness of continuous oral antibiotics versus antibiotics used only during episodes of illness in patients with cystic fibrosis. Twenty-two patients with cystic fibrosis were divided into two groups according to age, sex, and pulmonary status, and in a double blind fashion one group (A) was given cloxicillin (50 mg/Kg/day) and the other group (B) a placebo for 12 months. All other parts of the basic C.F. treatment program remained unchanged. The patients were evaluated quarterly using the following parameters: sputum volume and color, cough, physical examination, CBC, ESR, chest radiograph, pulmonary function tests and blood gas analysis. Of the 11 patients in group A, 10 improved or remained stable and 1 showed deterioration, whereas, in group B, 6 Improved or remained stable and 5 showed worsening. The data indicates that there is less progression of the pulmonary component of cystic fibrosis in patients who received continuous cloxicillin.