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Microscopy in the diagnosis of the cryptococcal meningitis

Cryptococcus neofromans is a yeast form encapsulated fungus which can infect the central nervous system; is ubiquitous in the environment and is related with pigeon's feces and lesser extent with bats worm. The penetration is fundamentally by airway and rarely by digestive 1-2 tract and skin . The risk groups are patients with HIV infection (78.1%), undergoing corticosteroid and anti-tumor necrosis factor antibody treatments (4.1%), autoimmune disease (2.3%), solid or malignant tumor (1.9%), transplant recipients (1.3%), diabetes mellitus (1.1%), liver cirrhosis (0.9%), chronic renal failure (0.3%) and 3 , 4 non estab l i shed cause (13.2%) . The cryptococcal meningitis presents with headache, neck stiffness, fever, vomiting, seizures, mental confusion, etc. The medical management includes draining to alleviate the intracranial hypertension, also antifungals like amphotericin, flucytosine and fluconazole for an extended period.