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Diminished adrenergic response to 2-deoxy-D-glucose after prolonged, exhausting physical exercise in dogs.

Effect of 2-deoxy-D-glucose (2DG) on plasma adrenaline, glucose and free fatty acid concentrations was studied in dogs under control conditions and after prolonged, exhausting physical exercise. The increase in all three variables in response to 2DG was significantly reduced following the exercise. The results suggest diminished responsiveness of adrenal medulla to the glucopenic stimulus after exhausting exercise.