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Mouse γδ TCR+NK1.1+ thymocytes specifically produce interleukin‐4, are major histocompatibility complex class I independent, and are developmentally related to αβ TCR+NK1.1+ thymocytes

Mouse T cells co‐expressing an αβ T cell receptor (TCR) and the NK1.1 antigen have been shown to be major interleukin (IL)‐4‐producing cells and could therefore regulate cell‐mediated immune responses. We have identified a related subset of thymocytes co‐expressing a γδ TCR and NK1.1 which also produce IL‐4. Unlike αβ+NK1.1+ thymocytes, the selection of γδ+NK1.1+ thymocytes is not dependent upon β2‐microglobulin (β2m)‐associated class I molecule expression because these cells are present in β2m‐deficient mice. This suggests that γδ+NK1.1+ T cells may regulate immune responses to a different variety of antigens. However, the development of αβ+NK1.1+ and αβ+NK1.1+ thymocytes appears to be related. Analysis of different mutant mice lacking αβ+NK1.1+ thymocytes revealed a specific increase in γδ+NK1.1+ thymocyte production when the block in αβ+NK1.1+ thymocyte differentiation occurs after β TCR rearrangement.