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Effects of quercetin in a mouse model of colitis associated colon cancer

Numerous in vitro studies argue for quercetin's chemopreventive potential in colon cancer; however, controlled experimental studies in rodent models are limited. We examined the effects of quercetin on tumorigenesis and associated sickness symptoms in a mouse model of colitis associated colon cancer. Male C57BL/6 mice were randomized to a Placebo (Pla) or 2% Quercetin (Quer) diet. Mice were fed their respective diet from 9–20 wks of age. To induce colon cancer, all mice were administered azoxymethane (AOM) (10mg/kg i.p) at 10 wks of age and then began 3 cycles of 2% DSS (7days on and 14days off in drinking water). Body weight and symptoms were examined twice weekly. At sacrifice, colon tumor number and size were recorded, as well as colon and spleen weights. Body weight was decreased by 34% in Pla (P<0.05), and Quer blunted this decline (P<0.05). Similarly, Quer decreased symptom score by 39% (P<0.05). Tumor number was reduced by 69% with Quer (P<0.05), and specifically, large tumor number by 65% (P<0.05). Quer also blunted the increase in spleen weight and colon weight by ~50% (P<0.05). These data suggest a beneficial effect of quercetin on tumorigenesis and associated sickness symptoms, as well as provide support for further development of this bioactive food component for prevention of colon cancer.