{'fraction_non_alphanumeric': 0.02096177558569667, 'fraction_numerical': 0.013563501849568433, 'mean_word_length': 4.927007299270073, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Hepato‐protective effects of alpha lipoic acid besides its role in preventing fatty liver disease

To the Editor: We thank Dr Castiella and colleagues (1) for their interest in our recent review (2). We agree that the role and importance of HFE genetic variations as risk factors for hepatic iron loading and for pathogenesis of porphyria cutanea tarda are variable. As they again point out, their recent report failed to find a significantly increased prevalence of either the C282Y or the H63D mutations in HFE among 54 subjects from the Basque region of Spain (3, 4). We also note that the prevalences of both genetic variations were higher in those with PCT than in controls, leaving open the possibility that, with larger samples sizes, significant differences might become apparent even among the Basques.