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Does ABO blood type is a novel risk factor for osteoporosis or low bone density among postmenopausal women or not?

ABO blood types may cause a vulnerability to individuals for conditions such as malignancies or chronic diseases. However, the interaction of ABO blood types and osteoporosis is inexplicit. In this study, we focused on the role of ABO blood types on bone health by comparing bone mineral density (BMD), and the prevalence of low bone mass (LBM) and osteoporosis among postmenopausal women. Non-institutionalized postmenopausal women aged over 50 years were prospectively enrolled in the study following the measurement of BMD by dual-energy X-ray absorptiometry (DEXA). The prevalence of osteoporosis and LBM were interpreted according to T scores of either site. Self-reported blood types of participants were noted. The study included 220 postmenopausal women, and the median age of participants were 59 (11) years (min:50 years, and max:82 years). The mean BMD values at the lumbar spine, femoral total, and femoral neck of participants were 0.821±0.118 g/cm2, 0.810±0.121 g/cm2, and 0.716±0.112 g/cm2, respectively. Both mean BMD and T scores of enrollees for either site were similar across blood types (p-value >0.05 for all). The prevalence of osteoporosis and LBM showed no significant association between blood groups (p=0.45, and p=0.226, respectively).The present study showed evidence of a similar BMD, the prevalence of LBM, and osteoporosis among postmenopausal women over 50 years regardless of ABO blood type.