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Effects of abatacept on monocytes in patients with rheumatoid arthritis

Abatacept represents a soluble recombinant human fusion protein comprising the extracellular domain of human CTLA-4 and a fragment of the modified Fc domain of human IgG1 (CTLA-4Ig). Due to the interaction with CD80/CD86, abatacept inhibits the binding of CD28 and thereby effector T cell activation. In addition, inhibition of CD80/CD86 binding might also exert effects on antigen presenting cells including cells of the myelo-monocytic lineage. The authors …