{'fraction_non_alphanumeric': 0.03278688524590164, 'fraction_numerical': 0.025021570319240724, 'mean_word_length': 5.236559139784946, 'pattern_counts': {'":': 0, '<': 1, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 1, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Abstract 15770: Plasma cBIN1 Based Heart Failure Index (HFI) Identifies Patients With HFpEF and Prognosticates Future Hospitalizations

Introduction: Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for half of the HF burden worldwide. Cardiac bridging integrator 1 (cBIN1) is a t-tubule protein essential for calcium signaling which correlates with cardiac health. Hypothesis: We hypothesize that a Heart Failure Index (HFI) based on plasma cBIN1 concentration is a diagnostic and prognostic biomarker in HFpEF patients. Methods: The HFpEF cohort comprises 52 stable patients with documented prior episodes of HF and with preserved left ventricular ejection fraction (LVEF≥50%). The control cohort includes 104 age and sex matched healthy volunteers. cBIN1 concentration was determined by a novel cBIN1-specific ELISA test. Patient characteristics were obtained per chart review and patients were followed for 1 year post cBIN1 assay. HFI is computed as the log of the normalized reciprocal of cBIN1. Results: Median HFI is 0 in the healthy population and is increased in the HFpEF population to 1.8 (p<0.0001). Receiver operator chara...