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Research Progress in Neoadjuvant Chemotherapy for Bladder Cancer

Neoadjuvant chemotherapy is a systemic pre-operative treatment which can eliminate microscopic lesion of bladder cancer including metastatic lesion. It significantly improves 5-year survival rate of bladder cancer. For patients with non-organ-confined bladder cancer, neoadjuvant chemotherapy combined with radical cystectomy can be a better treatment option. This article covers the current status of bladder treatment and the rise of neoadjuvant chemotherapy, advantages and disadvantages of neoadjuvant chemotherapy, prediction of efficacy of neoadjuvant chemotherapy, the choices for neoadjuvant chemotherapy patient, improvement of neoadjuvant chemotherapy, and large-scale clinical trial of neoadjuvant chemotherapy for bladder cancer.