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Comparative Effects of Aging Process on Phosphatidylcholine Biosynthesis Pathway: A Key Role for CTP‐Phosphocholine Cytidylyltransferase?

The effects of aging on phosphatidylcholine (PtdCho) biosynthesis were investigated in liver and brain subcellular fractions of the rat, by studying the activity and regulation of CTP phosphocholine cytidylyltransferase (CT), the rate limiting enzyme in PtdCho biosyntheses. With both tissues, CT activity was present in cytosolic and microsomal fractions, but in brain, CT activity seemed to escape to an inhibiting feed back mechanism. In brain, CT activity was greater in the microsomal fraction, whilst in liver, a higher CT activity was seen in the cytosolic fraction.