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AB0051 SEMAPHORIN 3A: A POSSIBLE MARKER FOR DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS

Background: Sema 3A is concerned in the pathogenesis of many autoimmune diseases because it is involved in regulation of immune responses and maintenance of self-tolerance. Regulatory T cells play an important role in maintaining immunological self-tolerance by suppressing autoreactive T cells. Sema3A promotes regulatory T cells by enhancing IL-10 production Objectives: The current study aimed at testing the possible role of Semaphorin 3A (Sema 3A) in activity and in remission in rheumatoid arthritis patients and to assess whether this level correlates with interleukin 10 (IL-10) level. Methods: Sixty Egyptian patients with rheumatoid arthritis (RA) were divided into three groups according to modified Disease Activity Score (DAS28), RA in high activity (group II, n=20), RA in moderate activity (group III, n=20) and RA in remission (group IV, n=20) and compared with 20 normal individuals (group I). Serum levels of Sema 3A and IL-10 were measured and correlated with ESR, CRP, Rheumatoid factor, DAS28 and Health Assessment Questionnaire (HAQ). Results: Serum Sema 3A levels were significantly lower in high activity (55.7 ± 15.5 pg/ml) than in moderate activity groups (72.9 ± 14.6 pg/ml, p = 0.002) and both levels are lower than those in remission group (77.2 ± 13.1pg/ml, p < 0.001 compared to high activity one) and the control groups (76.5 ± 23.6pg/ml, p < 0.001 compared to high activity one also), A significant negative correlation was detected between Sema 3A and each of ESR, CRP, DAS28 and HAQ. Serum IL-10 was higher in patient groups, with highest mean among group IV. Conclusion: reduced serum level of Sema 3A was found to be correlated with disease activity and indicating its usefulness marker for RA disease activity. Disclosure of Interests: None declared