{'fraction_non_alphanumeric': 0.044753086419753084, 'fraction_numerical': 0.013888888888888888, 'mean_word_length': 5.622448979591836, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Erythrocyte membrane proteins in sickle cell disease (598.1)

Sickle cell disease (SCD) is a common inherited hematological disorder where mutation causes substitution of valine for glutamate in β‐globin, giving hemoglobin S (HbS). HbS polymerization and cell dehydration cause cell distortion (sickling) at low oxygen tension, often leading to microvascular occlusion. Membrane changes are found in SCD, and increased Na+/H+ exchange activity mediated by NHE‐1 transporter has been reported. This study assayed levels of key nutrient (GLUT‐1 and hENT‐1) and ion (AE‐1 and NHE‐1) transporters to better understand pathophysiological changes in SCD.