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Mean platelet volume and mitral annular calcification.

We read the article ‘Relationship between mean platelet volume and mitral annular calcification’ written by Varol et al. [1] with a great interest. They have shown that mean platelet volume (MPV) and platelet distribution width (PDW) were significantly elevated in patients with mitral annular calcification (MAC) compared with controls. MPV was correlated with MAC, atrial fibrillation and left atrial and negatively correlated with platelet count. MPV and PDW were independently associated with the MAC independent of confounding factors. The authors suggested that elevated MPV values may indicate that patients with MAC have a higher risk of systemic thromboembolism due to increased platelet activation. The study is designed and presented successfully. We believe that these findings will work as a guide for further studies about the effect of inflammation on platelet indices in patients with mitral annular calcification. We thank the authors for their contribution to the literature.