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[Developmental patterns of dopaminergic neurons in dissociated cultures of the substantia nigra from mouse embryos].

Dopaminergic neurons of Substantia nigra of 18-19-day-old mouse embryos were dissociated and cultured in Maximov's chambers for 2 weeks. The neurons showed an active synthesis of dopamine beginning from the first week of cultivation as demonstrated by the histofluorescent method. It is suggested that the process of differentiation of dopaminergic neurons is relatively independent of target cells and is genetically determined. Nonuniform distribution of dopaminergic neurons in aggregates suggests that these neurons are capable of selective adhesion.