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Effects of pyrazole partial agonists on HCA2‐mediated flushing and VLDL‐triglyceride levels in mice

BACKGROUND AND PURPOSE Niacin can effectively treat dyslipidaemic disorders. However, its clinical use is limited due to the cutaneous flushing mediated by the nicotinic acid receptor HCA2. In the current study, we evaluated two partial agonists for HCA2, LUF6281 and LUF6283, with respect to their anti‐dyslipidaemic potential and cutaneous flushing effect.