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The metabolic and endocrine responses of neonates to surgical stress

Little is known of the ability of preterm and term neonates to respond to surgical stress. We have measured circulating levels of metabolic fuels and hormones pre-operatively; at the end of surgery and post-operatively in 27 neonates (20 term, 7 preterm) subjected to surgery. The overall results (table) show significant perioperative changes in fuel and hormone levels confirming that neonates can mount a stress response. Further analysis shows that the pattern of response is different to adults, and is influenced by severity of surgery and gestational age. Definition of the stress response to surgery in different groups of neonates may improve clinical management and prevent metabolic complications