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Applications of the Local Electrode Atom Probe in Biotechnology

The Local Electrode Atom Probe (LEAPTM) is an innovative three-dimensional atom probe microscope developed at Imago Scientific Instruments. An atom probe is a projection microscope coupled with a mass-spectrometer that provides quantum-level detection capability. The LEAPTM determines 3-D structure and composition by taking specimens apart piece-by-piece as single atoms, or as small molecular fragments. The position of each atom or molecular fragment within the specimen is imaged while elemental composition is simultaneously determined via time-of-flight measurement (see figure).