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Subchronic oral toxicity study of Habb-e-Suranjan in albino Wistar rats

Abstract Background Habb-e-Suranjan (HS) is a Unani pharmacopoeial formulation used for treatment of rheumatoid arthritis. The present study was carried to evaluate the toxic potential of HS in albino Wistar rats. Methods The subchronic was carried out at the dose levels of 2440 mg/kg of body weight in both sexes. The rats were observed carefully for any behavioral change for next 24 hours (hr) after the administration of the drug and daily twice thereafter till the completion of experimentation. Water/feed consumption and body weight were recorded on weekly basis. The rats were sacrificed on 91st day after overnight fasting. Blood was collected for hematological and biochemical analysis. The rats were dissected and organs were observed for any morphological changes. Organ samples were collected for histological studies. Results There were no incidences of mortality/morbidity found in any of the treated rats. HS caused no significant difference in the body weights as well as relative organs weights of treated groups when compared with the control groups. There were no significant changes found in any biochemical, hematological and histopathological parameters that could indicate any signs of toxicity. Conclusions The study suggests that HS is safe and did not induce any adverse effect in rats.