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INFLUENCE OF DIETARY NITRATE EXPSOURE ON THYROID HORMONE, SOMATOMEDIN-C/IGF-I CONCENTRATIONS AND GROWTH

Dietary goitrogens are important for the development of endemic goitre, especially in iodine deficiency areas. Due to the increasing nitrate exposure of humans, the influence of dietary nitrate was tested in three groups of 9 six week old piglets.The thyroid hormones and Sm-C/IGF-I levels of nitrate exposed animals (T4:<10; T3: 0.8±0.2, rT3:0.3±0.1 nmol/l, Sm-C:0.29±0.09 U/ml) were significantly lower after a five week test period with 412 mg NO3-N/100 g of diet compared to the ad libitum control group (29±6, 1.2±0.3, 0.5±0.1, 0.73±0.27).The mean daily weight gains amounted to 242±76, 274±67 and 303±94 g rsp. T4, T3 and rT3-levels of the nitrate exposed animals normalized after the supplementation with 0.08 mg iodine/100 g diet during 7 days, but the Sm-C/IGF-I concentrations of the nitrate-exposed and pair-fed groups were still diminished.Chronic nitrate intake inhibits in higher concentrations the thyroid hormone synthesis. Hypothyroidism as well as a probably nitrate induced inhibition of the eating centre lead to diminished Sm-C/IGF-I levels and so to growth retardation.