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Harnessing the Benefits of Exercise Induced Neurogenesis In Treatment of Alzheimer's Dementia

Neurogenesis is the process by which neurones are generated. Early neuro-anatomists considered the nervous system to be incapable of regeneration. Research has now shown that it can occur in the hippocampus if the adult human brain and that exercise may promote it by increasing blood flow to the brain and levels of Brain-Derived Neurotrophic Factor (BDNF). Dementia is associated with a decline in memory and cognition. Alzheimer's disease (AD) is the most common cause of dementia. It is caused by brain atrophy. An abnormal amount of amyloid in the brain is noted 1. Developed countries are experiencing ageing populations and a soaring incidence of Dementia. In absence of an effective drug, non-pharmacological options for prevention and treatment are being explored 8. I undertook a review of the evidence of neurogenesis, its induction by exercise and potential in treatment of AD. Furthermore, with the aid of a " Gedanken Experiment " I sought to propose ways to enhance medical research in this field. INTRODUCTION Our brain contains billions of nerve cells arranged in patterns that coordinate thought, emotion, behaviour, movement and sensation. A complicated highway system of nerves connects our brain to the rest of your body, so communication can occur in split seconds. The nervous system is formed by the neurons and associated cells. Interconnected with each other, neurons are able to provide efficient, lightning-fast communication.