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Design and Synthesis of a 3,2′-Indane]-1′,3′-Dione Derivative and Their Theoretical Interaction with the Coronavirus Surface (COVID-19)

Several drugs have been used for the treatment of coronavirus disease (COVID-19);however, these drugs have not produced any effect against COVID-19 In the search of a clinical alternative, the aim of this research was to synthetize a 3,2'-indane]-1',3'-dione (compound 6) from 2,4- Dinitrophenyl hydrazine to evaluate their interaction with COVID-19 (6UL7) using either chloroquine and remdesivir as controls in a theoretical model The results showed that compound 6 have a different affinity by 6UL7-protein surface compared with either chloroquine and remdesivir In addition, other data showed low binding energy for 6 compared with both hydroxychloroquine and remdesivir In conclusion, this phenomenon suggests that compound 6 could exert some change in the biological activity of COVID-19