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Neonatal thyroid deficiency: early temperamental and cognitive characteristics.

Sixty-nine children with congenital hypothyroidism detected through thyroid screening were compared with 39 unaffected siblings for cognitive and temperamental characteristics. Intelligence test results revealed: (1) IQs of hypothyroid children were normal but lower than siblings; (2) hypothyroid children were lower than siblings in gross motor and perceptual performance abilities; (3) athyrotic children had lower IQs than those with ectopic thyroids, goiter, or hypoplastic disease; (4) athyrotic, hypoplastic, and ectopic thyroid children had lower performance than verbal IQs, but there was no scale difference for those with goiter; (5) deficits differed according to test age; and (6) age of onset of treatment was not related to IQ or pattern of deficit. Temperament test findings revealed: (1) no increase in difficult or slow-to-warm-up children, (2) lower ratings were found for hypothyroid children than siblings on approach/withdrawal and persistence scales, and (3) higher rating was given for athyrotic children than those with goiter.