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Low level of p27(Kip1) protein expression in gastric adenocarcinoma is associated with disease progression and poor outcome

Low tumor expression of the p27Kip1 protein, which is involved in cell cycle control and apoptosis, is considered a negative prognostic factor in different types of cancer. The aim of this study was to evaluate the clinical and pathological significance of low p27Kip1 protein expression in patients who had undergone resection for gastric adenocarcinoma.