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Use of touch imprint cytology as a simple method to enrich tumor cells for molecular analysis

A relative excess of nonneoplastic cells in frozen carcinoma samples is often a cause of false‐negative results in molecular assays. Given the greater cohesiveness of epithelial tumor cells compared with nonneoplastic epithelium and mesenchymal stroma, the authors hypothesized that tumor procurement by touch imprinting would provide a simple, cost‐effective method of obtaining enriched neoplastic cells compared with frozen whole‐tumor samples.