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Abstract T MP112: Physical Activity Improves Stroke Outcome Through Modulation of Neutrophil Polynuclear Mobilization


 Introduction:
 Physical activity has been previously reported to decrease severity of stroke in patient cohorts. Experimentally, in rats submitted to chronic physical activity, the infarct size is decreased and functional outcome is improved, with a decrease of neutrophil polynuclear mobilization.
 
 
 Hypothesis:
 We assessed the hypothesis that beneficial effect of physical activity observed in stroke could be related to neutrophil modulation.
 
 
 Methods:
 We recruited patients with supratentorial cerebral ischemia within 48 hours of symptom onset. We evaluated the presence, weekly duration and intensity (light, moderate, heavy) of previous physical activity. The primary end-point was the initial severity assessed by the NIHSS. The secondary end-point was neutrophil polynuclear count. Myeloperoxydase, chemokines (Monocyte Chemoattractant Protein-1, C-X-C chemokine 10), adhesion proteins (InterCellular Adhesion Molecule-1, vascular cell adhesion molecule1), von Willebrand factor, cytokines (interleukins-6, -8, -10) were dosed in plasma through Luminex methodology.
 
 
 Results:
 Of the 434 patients (mean age of 67 ± 15 years, 53% of men), 227 (52.3%) had a regular physical activity before ischemic event. Previous regular physical activity was independently associated with a lower severity of ischemic event assessed by the NIHSS (4.0 [1-9] vs 6.0 [2-15] ; p<0.002) and lower concentrations of neutrophil polynuclear (5.0 [3.8-6.4] vs 5.7 [4.1-7.7]; p<0.003), chemokines, interleukins, Von Willebrand factor, and myeloperoxydase. There was no strong evidence of difference in biological parameters according to duration of physical activity. Patients with moderate and heavy intensity had a lower level of chemokines, interleukins-8 and Von Willebrand factor.
 
 
 Conclusion:
 In conclusion, previous regular physical activity improves initial stroke severity through decrease of neutrophil polynuclear count. The decrease of attractant chemokines could suggest a decreased mobilization of neutrophils to parenchyma rather than an effect on neutrophil-endothelium interaction since adhesion proteins are not changed.
