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NKCC1 as a regulator of vascular tone and a novel target for antihypertensive therapeutics.

NA -K -2CL COTRANSPORTERS (NKCCs) belong to the superfamily of Cl-coupled carriers and provide electroneutral symport of Na ,K , and Cl. Two NKCC isoforms have been cloned from vertebrate cDNA libraries. NKCC2 is exclusively expressed in the apical membranes of thick ascending limb and macula densa and plays a major role in renal handling of salt and osmotically obliged water. In contrast, NKCC1 is expressed in all types of cells studied so far, including vascular smooth muscle cells (VSMC), and its role in tissue-specific