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A Review on Current Applications of Bilayer Tablets

Bilayer tablet technology is an improved beneficial technology to overcome the shortcomings of the single-layered tablet. The introduction of bilayer tablets into the pharmaceutical industry has enabled the development of pre-determined release profiles of active ingredients and incorporation of incompatible active ingredients into a single unit dosage form. Bilayer tablets provide one of the important design approaches where incompatible drugs, with a different indication, and same drug with different release rate can be incorporated in a single unit. Bilayer tablet is suitable for sequential release of two drugs in combination, and for sustained release tablets in which one Layer is immediately released as initial dose and the second layer is a maintenance dose. Bilayer formulations carry one drug, and deliver each of them without any pharmacokinetic or dynamic interactions, with their individual rate of delivery. Controlled release dosage forms have been extensively used to improve therapy with several important drugs. Use of bilayer tablet is a very different aspect for anti-inflammatory and analgesic drugs. This review discusses various applications of bilayer tablets such as controlling of delivery rate, providing synergic property and agonistic effect, administration of fixed-dose combinations etc. In sustained release tablet formulations, the commonly used functional ingredient is HPMC and in immediate release, the commonly used functional ingredients are Sodium Starch Glycollate, Crospovidone, and Croscarmellose sodium.