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[Human leucocyte antigen-DPA1 polymorphism distribution in Chengdu Chinese families with intrahepatic cholestasis of pregnancy].

OBJECTIVE
To investigate the relationship between human leucocyte antigen (HLA)-DPA1 region gene polymorphism and intrahepatic cholestasis of pregnancy (ICP).


METHODS
The HLA-DPA1 alleles of 25 ICP families and 25 normal control group families were analysed by polymerase chain reaction-sequence specific primers(PCR-SSP) method.


RESULTS
The analysis of the frequencies and feto-maternal or couples sharing of the DPA1 alleles showed that no statistically significant difference was observed between the two study groups.


CONCLUSION
It is unlikely that an HLA-DPA1 allele is primarily associated with susceptibility or resistance to ICP.