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Determination of sibship by microsatellite typing in a deficiency case of disputed maternity: further study.

In a deficiency case of maternity dispute where the father and his two wives were dead and only the six children were available for testing, we analyzed three sex-linked short tandem repeat (STR) loci DYS19, HPRT, and AR. On the basis of the typing results of the HPRT and AR loci, we obtained probabilities of maternity ranging from 0.9256 to 0.9724 for five of the six children. The results supported those of typing for 24 conventional hemogenetic markers and 11 autosomal STRs, enabling us to establish maternity. The present study demonstrates the utility of sex-chromosomal STR typing in the solution of deficiency cases of disputed parentage.