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[Change in the behavioral and electrophysiological indices in rats with cerebrovascular disorders].

Behavioural and electrophysiological indexes have been investigated during bilateral ligation of common carotid arteries in rats. It has been established that 24 hours after cerebrovascular disorders blood flow in parietal cortex decreased by 61 +/- 7.8%. At the same time disorders of the vital functions have been observed, namely, death of animals, progressive weight loss, reduced resistance to anoxia. Disorders in instinctive behaviour were noted, such as inversion in preference of dark section to the light one, and diminished elaboration of conditioned reflex in a shuttle-box, as evidenced by the low correct responses to intersignal reactions ratio. In case of cerebrovascular disorders test response was depressed, it reflecting disorders in the cortical system of recurrent inhibition and indicating the decrease in the functional activity of GABAergic processes.