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[Genetic epidemiologic study of mitochondrial DNA 7445A-->G mutation among non-syndromic deafness in Chinese population].

OBJECTIVE
To study the Mitochondrial DNA 7445A-->G mutation in nonsyndromic deafness patients in Chinese population.


METHOD
Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were used to screen the mitochondrial DNA 7445A-->G mutation among 128 nonsyndromic deafness individuals from 32 pedigrees, 135 sporadic nonsyndromic deafness patients and 100 normal subjects.


RESULT
The 7445A-->G mutation did not appear in the experiment.


CONCLUSION
Incidence of the mitochondrial 7445A-->G mutation was lower than that of mtDNA 1555A-->G mutation in nonsyndromic deafness patients in China.