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Effect of Resistance Exercise with Blood Flow Restriction on Muscle Protein Synthesis and mTOR Signaling in Older Men

Recent studies have shown low‐intensity (20~50% of 1‐repetition maximum) resistance training combined with a moderate reduction of vascular flow to working muscles produces similar increases in hypertrophy and strength compared to traditional high‐intensity training. Seven male subjects (age > 60 years) performed low intensity resistance exercise on separate days with (BFR n=7) or without (Control n=7) a blood flow restriction cuff placed proximally on each leg. Blood samples were obtained throughout the study and muscle biopsies were taken at baseline, immediately, 1 and 3hr post‐exercise. Mammalian target of rapamycin (mTOR) signaling was assessed using immunoblotting methods. mTOR phosphorylation increased post‐exercise in both groups. S6K1 phosphorylation increased at 3hr post‐exercise in the BFR group only. rpS6 phosphorylation was higher 1 and 3hr post‐exercise in the BFR group and higher at only 1 hr post‐exercise in the Control group. The increase from baseline for muscle protein synthesis during post‐exercise recovery was ~80% in the BFR group and only ~10% in the Control group. We conclude that blood flow restriction during low intensity resistance exercise appears to enhance muscle protein synthesis and mTOR signaling in older men which may be an effective strategy to counteract sarcopenia.