{'fraction_non_alphanumeric': 0.05086206896551724, 'fraction_numerical': 0.05, 'mean_word_length': 4.450704225352113, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Acute fatty liver of pregnancy (AFLP) – an overview

Acute fatty liver of pregnancy (AFLP) is a rare condition that is estimated to affect 1/7,000 – 1/16,000 deliveries (Reyes et al. 1994; Pockros et al. 1984). It is associated with microvesicular fatty infiltration of the liver and possibly kidney (due to defective beta oxidation of fat) leading to fatty liver and renal insufficiency very early in the course of the disease (Castro et al. 2000). It was first described by 1940 by Sheehan in a series of six pregnancies (Sheehan 1940). It almost always occurs in the third trimester, however it has been reported as early as 23 weeks’ gestation (Suzuki et al. 2001). The average gestational age at delivery reported in one series is 35.2 weeks (Fesenmeier et al. 2005). Very occasionally, it has been diagnosed in the first few days postpartum. More than half (50 – 70%) of AFLP can have associated pre-eclampsia with or without haemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome (Gracia and Lavergne 2001). Like pre-eclampsia, most (57%) of the affected women are nulliparous and it is more common in twin pregnancies (Usta et al. 1994).