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Quantitative Studies of In Vitro Inhibition of Streptococcus mutans Plaque Formation by Organic Amines

The abilities of five, long-chain aliphatic monamines to inhibit the deposition of Plaque formed by Streptococcus mutans on stainless-steel wires were determined. The compounds along with their relative inhibitory potencies that were studied are N-methyltetradecylamine, hexadecylamine, dodecylamine, N-ethyldodecylamine, and octylamine. Activities are compared with critical micelle concentrations, partition coefficients, and quantum mechanical charges on the amine nitrogens.