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PREPARATION AND EVALUATION OF SOLID DISPERSIONS OF CELECOXIB Research Article

Celecoxib is a non-steroidal anti-inflammatory drug. The present study was planned to prepare and evaluate the solid dispersions of Celecoxib. Solid dispersions of Celecoxib were prepared by using various hydrophilic carriers like PVP-K-40, PEG 6000, PEG 4000 and Dextrin in various ratios by melt-in solvent method and solvent evaporation technique. The prepared solid dispersions were subjected to solubility studies (in water, 0.1N HCl and phosphate buffer pH 7.4) and drug content uniformity studies. The in-vitro release studies were carried out with USP type I dissolution apparatus (100 rpm, 37 ± 2 o C) in phosphate buffer pH 7.4 and stability studies were carried out at 40 ± 2 o C and 75± 5% RH. The cumulative amount of drug release at the end of 2 hours of Celecoxib: PVP was 96.86%, Celecoxib: PEG-4000 was 97.06 %, Celecoxib: PEG-6000 was 97.32% and Celecoxib: dextrin was 98.05%. Therefore, it can be concluded that the dissolution rate of poorly soluble drug Celecoxib can be significantly enhanced by formulating it into solid dispersions.