{'fraction_non_alphanumeric': 0.0711340206185567, 'fraction_numerical': 0.06134020618556701, 'mean_word_length': 4.467605633802817, 'pattern_counts': {'":': 0, '<': 2, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Abstract 10823: Familial Hypercholesterolemia in the Brazilian Adult Population: Prevalence and Factors Associated According to the National Health Survey


 Introduction:
 Familial Hypercholesterolemia (FH) is a genetic dyslipidemia associated with premature coronary artery disease (CAD) and stroke, however it is underdiagnosed. The World Health Organization recognizes FH as a public health priority and recommends early diagnosis and treatment. In Brazil, the prevalence of FH in population representative studies is lacking.
 
 
 Objective:
 To estimate the prevalence and investigate factors associated with FH in the Brazilian adult population.
 
 
 Methods:
 A total of 8,521 adults over 18 years old from the National Health Survey (NHS, 2014-2015) were included in this cross-sectional analysis. FH was defined by the Dutch Lipid Clinic Network criteria (Dutch MEDPED). Possible FH was defined in individuals who scored 3 to 5 points: premature CAD (2 points) and/or cerebral disease (1 point), and LDL-Cholesterol (mg/dL): 155-189 (1 point), 190-249 (3 points), 250-329 (5 points), ≥330 (8 points). The prevalence of FH was estimated according to sociodemographic, lifestyle, and health conditions variables and differences were evaluated using the chi-square test (p ≤ 0,05).
 
 
 Results:
 The prevalence of possible FH was 0.96% and it was higher in women (1.22%; p = 0.04), individuals of 45 to 59 years (1.74%; p = 0.004), white race (1.13%; p = 0.05), illiterate or with incomplete elementary school (1.55%; p = 0.002), in the presence of hypertension (1.75%; p = 0.002), diabetes (1.85%; p = 0.02), total cholesterol ≥310 mg/dL (53.94%; p < 0.001), and poor/very poor health self-assessment (2.40%; p < 0.001).
 
 
 Conclusions:
 FH was frequently present in the Brazilian adult general population (1:104 individuals). The early identification of FH may contribute to reducing the burden of premature CAD in the country.
