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HSP70 and HSP90 Inhibitors Repress Expression of TSC1 in T24 Bladder Cancer Cells and UOK139, UOK 140 Kidney Cancer Cells

Normal cells are able to survive in stressful conditions by increased expression of heat shock protein (HSP) genes. Both HSP90 and HSP70 are up regulated in cancers of the bladder and kidney. Next generation sequencing studies have identified pathways involved in kidney and bladder cancer. The objective of this study was to elucidate the impact of HSP70 and HSP90 inhibition on the signal transduction pathways driving their tumorigenic process. The TSC1‐TSC2 complex has emerged as a central signal‐integrating node within the cell.