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Prediction of Blastocyst Quality from Morphokinetic Criteria.

Background
The assisted reproductive technologies continue to improve in both techniques and results. The goal to achieve better clinical pregnancy rates by using time-lapse video cinematography as a non-invasive selected embryo transfer method, now under investigation.


Objective
This study aims to verify the morphokinetic criteria to discriminate good morphological blastocyst (group I) from poor morphological blastocyst (group II) by using Primo vision® (Vitrolife, Sweden).


Material and Method
The prospective study was performed in infertile couples treated with assisted reproductive technology at Thammasat Fertility Center, Thailand, in 2015. The morphokinetic study was compared between the two groups by t-test and Mann-Whitney U test with p<0.05 as statistical significance.


Results
Total of 63 blastocysts from 20 infertile couples was included. Thirty-three good quality blastocysts (52.38%) in group I and 30 poor quality blastocysts (47.62%) in group II were under morphokinetic study. T5 and CC3 were longer in group I compared to those in group II (mean = 51.85 and 15.04 vs. 47.98 and 12.42 hours, p = 0.03 and 0.04, respectively). Tm of group I was shorter than group II (mean = 88.16 vs. 96.64 hours, p = 0.00), Tb and S2 were also shorter in group I compared to those in group II (median = 109.50 and 1.00 vs. 118.19 and 1.95 hours, p = 0.00 and 0.02, respectively).


Conclusion
T5, CC3 and S2 of cleavage stage could be used to predict the quality of blastocyst. Tm and Tb of blastocyst stage are also useful in good quality blastocyst selection.