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[Liver tumors in the therapy with contraceptives and anabolic steroids].

Liver tumors described histologically as hepatocellular adenoma focal nodular hyperplasia and hamartoma have been reported in 64 patients treated with oral contraceptives 1973-76. Many cases have probably remained unreported. In addition 14 cases of hepatocellular carcinoma have been reported in patients treated with oxymetholone prednisone and methyltestosterone and other androgens. Symptoms diagnosis and treatment of these tumors are outlined; it is noteworthy that the majority of the benign tumors reported in the literature were found by chance during laparotomy for some other condition. Possible pathogenetic mechanisms of a causal relationship between hormone treatment and liver neoplasms are discussed.