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[Certain parameters of platelets oxygen metabolism in patients with multiple sclerosis].

The hypothesis of Mickel (1975) on multiple sclerosis suggested disturbances of lipid peroxidation in that disease. The purpose of this report was an analysis of oxygen metabolism in platelets in that disease, taking into account the peroxidation of lipids and antioxidant enzymatic protection against oxygen stress. In the reported study the concentration of malonyl dialdehyde (MDA) and the activity of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD-1) were determined in multiple sclerosis patients. The studied group comprised 20 non-smoking patients (9 men and 11 women) aged 21-61 years during disease exacerbation. The criteria of disease diagnosis were those suggested by Poser et al (1983). The obtained results may suggest abnormal acceleration of lipid peroxidation in platelets in this disease.