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Selected pharmacological studies of succinic semialdehyde.

Succinic semialdehyde was found to exhibit, in the rat, significant blood-pressure-lowering properties, a negative inotropic and chronotropic effect, and smooth muscle relaxant properties. No anticonvulsant activity was observed in either chemoshock or minimal and maximal electroshock procedures. Succinic semialdehyde was found to be devoid of any CNS activity in the doses employed.