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Urinary cytokines: clinically useful markers of chronic renal disease progression?

Many factors that drive glomerular and tubulointerstitial fibrogenesis have been identified. These include hemodynamic factors, chemokines, inflammatory mediators, cytokines, and lipids. These strides in knowledge are important in identifying those patients at increased risk of progressive renal disease as well as in developing targets for therapeutic interventions. Identifying ‘progressors’ is crucial since the distribution of the slope of the glomerular filtration rate of patients with chronic kidney disease is not normal. Some patients appear to progress very rapidly, such as those with diabetes, whereas other patients fail to progress at all. Developing strategies targeted at identifying the fast from the slow progressors is therefore of paramount importance if we are to deploy resources rationally in the management of patients with chronic kidney disease. The use of urinary cytokine markers as predictors of progression of renal disease is reviewed in this paper.