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420 Fetal Growth, Preterm Birth, Neonatal Stress and Risk for Cns Tumors in Children: A Nordic Populationand Register-Based Case- Control Study

We investigated the association between indicators of fetal growth and neonatal stress and CNS tumours diagnosed in the Denmark, Sweden, Norway and Finland in 1985-2006, using data from national cancer registries and medical birth registries. We included 3,443 children with primary CNS tumours and 16169 individually matched controls drawn randomly from the national population registries. We observed a U-shaped relation between risk for CNS tumors and birthweight, at >4.5 kg (OR 1.27; 95% CI, 1.03-1.55) and 38 cm (1.80; 95% CI, 1.18- 2.74), 5-minute Apgar score < 7 (1.44;95% CI, 0.98-2.12), and breech presentation (1.33; 95% CI, 1.04-1.69). The observed associations varied little by histologic subgroup. This study provides evidence that several intrauterine and neonatal factors are associated with higher risk of CNS tumours, indicating an early onset or, alternatively, potentially harmful exposures in the neonatal period that might be preventable.