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Effects of biological response modifiers on plasminogen activator activity in epidermal cell culture

The epidermis is a tissue in which cell proliferation and differentiation are ordinarily tightly coupled. Often when this regulation breaks down, pathology results. In recent years, plasminogen activator (PA), the enzyme classically related to the fibrinolytic cascade (Wilman & CoIIen, 1978), has been associated with the extravascular processes of cell proliferation (Ossowski, Biegel & Reich, 1979), cell migration (Christman et al.-, 1975) and tumorigenesis (Christman, Silvcrstcin & Acs, 1977). The growing awareness of an extravascular function for PA led us to investigate the role of this enzyme in epidermal function. Previous experiments have revealed that the epidermis produces a variety of PAs of different molecular weights as well as an inhibitor of PA (Brown, 1982; Brown & Chambers, 1979, 1983; Chambers, Brown & Cohen, 1983)Additionally, PA is related temporally to the cell's commitment to the differentiation process.