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The genetics of the autoimmune thyroid diseases.

AIM
To understand the modern approach to finding the genes responsible for complex diseases when compared to simple Mendelian inheritance. To define the autoimmune thyroid diseases as we now understand them and introduce the concept of disease heterogeneity. To review the evidence for a genetic contribution to autoimmune thyroid disease as opposed to environmental factors and to be aware of new information generated from recent studies concerning the role of HLA, immune modulators, and new loci of interest providing susceptibility to the autoimmune thyroid diseases.