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Effects of sex-steroid hormones on growth and hormone receptor levels of human uterine leiomyosarcoma cells in vitro.

The effects of 17β-estradiol and progesterone on SKN-I cells (human uterine leiomyosarcoma cells) were studied for concentrations ranging from 1 pM to 100 μM in Vitro. 17β-Estradiol enhanced cell proliferation at 1 μM or lower, but suppressed it at higher concentrations (>10 μM). On the other hand, progesterone did not affect the cells at lower than 0.1 μM, but suppressed their growth at higher than 1 μM. The cells showed degenerating morphological changes 24 hours after administration of higher than 10 μM of these hormones. In cells treated 4 days with 17μ-estradiol (0.1 to 10 nM), basal progesterone receptor levels increased from 1.3 to 2.25 pM/mg DNA and these effects of 17β-estradiol were suppressed by the antiestrogen tamoxifen at 1 μM.