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Insight into the recognition mechanism of EcoRV

EcoRV, a restriction enzyme in Escherichia coli, destroys invading foreign DNA by cleaving it at the center step of a GATATC sequence. In the EcoRV–cognate DNA crystallographic complex, a sharp kink of 50° has been found at the center base‐pair step (TA). In a previous research, we have examined the interplay between the intrinsic propensity of the cognate sequence to kink and the induction by the enzyme, and have understood the mechanism of action of the enzyme and the intrinsically behavior of the cognate sequence to undergo a kink allowing the proper placement of the atoms for cleavage. We have also demonstrated that the enzyme requires 2 magnesium ions at the catalytic site to perform the cleavage.