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2454-PUB: Hypoglycemic Symptoms in the Absence of Diabetes: Pilot Evidence of Clinical Hypoglycemia in Young Healthy Women

Background: Hypoglycemic symptoms in the absence of diabetes remains a common complaint in endocrinology practices, but remains understudied and lacks clinical definition and evidence-based recommendations for diagnosis or treatment. Our goal was to pilot test the concordance of hypoglycemic symptoms with low glucose values in young healthy individuals. Methods: We recruited 8 individuals who reported regularly experiencing symptoms consistent with hypoglycemia to wear a blinded Dexcom continuous glucose monitor and report symptoms for seven days. We excluded individuals with diabetes or other known causes of hypoglycemia. Results: All participants experienced glucose values Conclusions: Individuals with hypoglycemic symptoms in the absence of diabetes experience clinical hypoglycemia, indicating the need to understand the etiology, behavioral responses, and other health risks that might be associated with this condition. Disclosure M. Mongraw-Chaffin: None. D. McClain: None. D.P. Beavers: None. Funding National Center for Advancing Translational Sciences (UL1TR001420)