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Regional White Matter Hyperintensity Volume and Cognition Predict Death in a Multiethnic Community Cohort of Older Adults

White matter hyperintensities are distributed patches of increased lucency on T2-weighted MRI commonly present in older adults. Studies have generally supported the idea that they reflect ischemic damage due to small vessel occlusive disease, but there is emerging evidence that the underlying pathology and clinical outcomes vary based on their regional distribution. For example, WMH in anterior regions may reflect pure ischemic damage whereas posterior distributions may reflect more heterogeneous pathology, including