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Changes in Morphology and Structure of AVN in Spontaneously Hypertensive Rats

Objective: To investigate the changes of the morphology and structure of atrioventricular node and the intervention role of irbesartan in spontaneously hypertensive rats. Methods: WKY and spontaneously hypertensive rats were randomly divided into three groups with 10 rats in each group: 1WKY group( control group); 2SHR group( the model group); 3irbesartan treated group( the treatment group). The treated group was injected with irbesartan 0.6 m L·100 g- 1·d- 1and performed intragastric administration for 8 weeks,while SHR group and WKY group were treated with the same dose saline. Then the changes of blood lipid and the pathological changes of atrioventricular node were observed under light microscope. Results: After 8 weeks of treatment,blood lipid changes in the model group were significantly higher than that in the normal group,while the HDL values were significantly decreased( P 0. 05) in the model group. Compared with the model group,the serum TG,LDL and TC in the treatment group were significantly decreased,while the HDL value was significantly increased( P 0. 05). In the control group,the cells were small and dense in the atrioventricular node area,but there was no degeneration and necrosis of the atrioventricular node cells. In the model group,the arrangement of the atrioventricular node cells was disordered; the fracture was concentrated in the cytoplasm,and there was a small amount of inflammatory cells in the model group. In the treatment group,the arrangement of atrioventricular node cells tended to be neat,and the model group was significantly reduced. Conclusion: Eight weeks later,the AVN of model group of rats,appears interstitial collagen remodeling. Irbesartan can reduce the blood pressure of the rats in the model group and improve cardiac function. The deposition of interstitial collagen in the atrioventricular node can be reduced to varying degrees.