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Growth inhibition of Malassezia species by pharmacological concentrations of polidocanol

Summary. In vitro antifungal properties of polidocanol (Thesit®), a hydroxypolyethoxydecan, were investigated against various yeasts at concentrations of 0.05–10% (w/w) by means of the agar diffusion test; in the case of lipophilic Malassezia furfur, polidocanol‐containing olive oil was used additionally for sensitivity study. Six strains of M. furfur of different clinical origin were tested as well as strains of C. albicans (3), C. krusei (3), C. parapsilosis (2), C. robusta (2), Tr. cutaneum (2) and one strain each of C. guiliermondii, C. glabrata, C. tropicalis and M. pachydermatis. Both test systems revealed predominantly fungistatic activity against M. furfur, with a minimal inhibitory concentration (MIC) of 1% polidocanol (w/w), while yeasts of other genera (Candida species, Trichosporum species) showed no or only transitory (C. krusei) inhibition of growth.