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Histologic study of a bovine demineralized bone matrix on bone repair process in rabbits calvaria.

The aim of this study was to evaluate histologically the bovine demineralized bone matrix, Osseobond, on bone repair process in rabbit's calvaria. Nine rabbits were used and two surgical defects were created on each calvaria, one was just filled with the animal blood and the other was filled with demineralized bone matrix. The animals were sacrificed in postoperative period of 3, 7, and 15 weeks. Specimens on light microscopy analysis revealed that bone repair were improved on cavities filled with bovine demineralized bone matrix.