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Juvenile chronic lymphocytic thyroiditis: clinical, laboratory and histological correlations.

ABSTRACT Thirty-two children with histologically proven chronic lymphocytic thyroiditis were assessed for clinical, laboratory and histological correlations. An inverse relationship between radioimmunoassayable thyroid-stimulating hormone (TSH) and serum thyroxine by column (T4), and TSH and free thyroxine (FT4) was demonstrated. Significant correlations were noted between TSH levels and thyroid tanned red cell hemagglutination antibodies (χ2=4.78, p <0.05), and unfixed Coons antibody titers (χ2=13.26, p <0.005). Abnormal radioactive iodine uptakes were found in 11 of 22 patients examined. A statistically significant linear correlation between the 4-hr uptake and log serum TSH was shown (γ=0.683, p <0.01), while the 24-hr uptake had no correlation. Utilizing the relation between TSH and T4, and TSH and thyroid antibody titers, 18 of 19 patients with elevated TSH levels could be predicted by the selected criteria of a T4 <4.0 μg/100 ml or an agglutinating titer⋝1: 256 or a Coons fluorescent antibody titer⋝...