{'fraction_non_alphanumeric': 0.02483900643974241, 'fraction_numerical': 0.020239190432382703, 'mean_word_length': 4.787234042553192, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Effect of Hypericum Extracts on Monoamine Oxidase and Monoamine Neurotransmitters

AIM The purpose is to investigate the possible mechanism of antidepressive effect of hypericum extracts. METHODS The monoamine oxidase(MAO A B) activities were measured in the brain tissue of mice. The effects on levels of monoamine neurotransmitters and their metabolites in rats limbic area and striatum were evaluated using HPLC electrochemical detector. RESULTS At 250 mg/kg, the hypericum extracts showed an inhibition of 12.6% on MAO B activity, and the activities of MAO A B were decreased to about 13.2% and 18.8% of the control level by 500 mg/kg. A significant increase in the DOPAC content of the striatum was observed at the dose of 250 mg/kg. While at 500 mg/kg, it elicited an increase of NA, DA, DOPAC?HVA and 5 HIAA levels in limbic area, and a remarkable increase of DA, DOPAC and HVA in striatum was observed. CONCLUSION The possible mechanism of hypericum extracts for antidepressive action may be involved in inhibition of MAO activities and the uptake of monoamine neurotransmitters.