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Stimulation of the pelvic nerve increases bladder capacity in the prostaglandin E2 cat model of overactive bladder.

Selective electrical stimulation of the pudendal nerve exhibits promise as a potential therapy for treating overactive bladder (OAB) across species (rats, cats, and humans). More recently, pelvic nerve (PelN) stimulation was demonstrated to improve cystometric bladder capacity in a prostaglandin E2 (PGE2) rat model of OAB. However, PelN stimulation in human or an animal model that is more closely related to human has not been explored. Therefore, our objective was to quantify the effects of PGE2 and PelN stimulation in the cat. Acute cystometry experiments were conducted in 14 α-chloralose-anesthetized adult, neurologically intact female cats. Intravesical PGE2 decreased bladder capacity, residual volume, threshold contraction pressure, and mean contraction pressure. PelN stimulation reversed the PGE2 induced decrease in bladder capacity and increased evoked EUS EMG activity without influencing voiding efficiency. The increases in bladder capacity generated by pelvic nerve stimulation were similar in the rat and cat, but the stimulation parameters to achieve this effect differed (threshold amplitude at 10 Hz in rat vs. twice threshold amplitude at 1 Hz in cat). These results highlight the potential of PGE2 as a model of OAB and provide further evidence that PelN stimulation is a promising approach for the treatment of OAB symptoms.