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Adverse reaction to potassium iodide from a cough syrup

In three T-cell clones of the double-negative phenotype, we measured the in vitro production of chemokines of the C-C type, and we found high atnounts secreted (12-28 ng/ml for RANTES, 21-48 ng/ml for MlP-la, atid 10-64 ng/tnl for MIP-ip), independently of the Th type of the clones. The stable presence of this double-negative Th2 type subset has not been assessed by other studies. The patient survived after 3 years' observation, and spontaneously recovered from the hypereosinophilia and the sytnptoms described, after reintroduction of antiretroviral treatment. Studies of his T-cell lunction are in progress, but the CD4+ cell nutnber further decreased, thus pointing to the possible role of this cell in the hypereosinophilic syndrome observed. The high production of C-C chemokines in an AIDS patient with hypereosinophilia may be due to various causes, but it is very unlikely to have been due to antiviral defense tnechanistns (8). C-C chemokines act as potent activators of eosinophils, and may be implicated in allergic tnanifestations (9). Our observation highlights two main points: