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Neuropeptide Y and Prenatal Stress: NPY's role in early programming for Obesity and Anxiety in Adulthood

Prenatal stress predisposes humans and animals to psychological and metabolic disturbances in adulthood, however, the process by which it exerts its long‐lasting effects is not fully understood. We studied long‐term effects of prenatal stress on anxiety, stress response, and reaction to a high fat (HF) diet during adulthood. Neuropeptide Y (NPY), an endogenous orexigenic and anxiolytic compound, may play a role in the development of anxiety, obesity, and dysregulation of the HPA axis in adulthood.