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Infectious mononucleosis with thrombocytopenic purpura.

A case of infectious mononucleosis with longstanding thrombocytopenia, not responsive to corticosteroid therapy, is presented. Rapid normalization of the platelet level was revealed by splenectomy. The patient is the fourth known case in which it has been necessary to perform splenectomy. A study made with 51Cr-labelled homologous platelets showed a very short half-life, along with a high spleen/liver ratio of the activity. These examinations have not previously been performed in this condition.