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Occult Bacteremia in Young Children with Very High Fever Without a Source: A Multicenter Study

We carried out a prospective multicenter study including 203 previously healthy well-appearing children who were 3–24 months old with fever without a source ≥40.5°C. Thirty-one (15.3%, 95% confidence interval 11.0–20.9) were diagnosed with serious bacterial infection, including 6 with bacteremia (3%, 95% confidence interval 1.4–6.3). Testing for occult bacteremia in children 3–24 months old with fever without a source should be considered when fever at ≥40.5°C.