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Recent Advances in Construction of C(sp2)-O Bonds via Aryne Participated Multicomponent Coupling Reactions

Aryne chemistry is a powerful synthetic technique that forge new bonds on aromatic rings. The recent resurgence of aryne based multicomponent coupling strategy has led to an influx of methodologies for the mild synthesis of arene derivatives. In particular, these innovative discoveries broaden and streamlines approaches toward phenol ether motifs, which are prevalent structural component across a broad range of chemistry related research field. Herein, this review aims to provide a comprehensive overview on recent progress in construction of C(sp2)-O bonds via aryne induced multicomponent reactions. Special attention has been focused on elucidating the reaction design and mechanistic pathway.