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Cases and Specimens Carcinoid Syndrome Resulting from a Primary Argentaffinoma of the Ovary

Mrs M S, aged 58 History: Six years' bronchospasm, hypertension and increasing diarrhoea. Five years' increasing facial erythema with severe cold-induced cyanosis. Attacks of severe flushing associated with throbbing in the head, borborygmi and the passage of a watery stool. Two years' increasing ankle oedema and dyspnoea. All ascribed by her medical advisers at the time to 'nerves' and by herself to poison. Findings on admission: Facial: telangiectasia; flushing and cyanosis together. Cardiovascular: right heart failure with ankle cedema and a large tender liver; tricuspid incompetence. Pulmonary: bronchospasm. Abdominal: large lower abdominal mass producing diarrhoea when palpated. Investigations: Chromatography of 24-hour urine showed presence of 5-hydroxy-indole-acetic acid.