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Psoriasiform changes in guinea-pig skin from propranolol.

Summary 
 
Psoriasiform eruptions of the skin are recognized as a not uncommon adverse effect of practolol and other β-adrenergic blocking drugs. Topical application of propranolol to guinea-pig skin causes thickening of the skin with histological changes strikingly resembling psoriasis in man. These findings suggest that propranolol has a direct pharmacological effect on the skin.