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Modeling and Analysis of Gab1 Mediated Feedback Loops to Understand Gab’s Role in Erk-Akt Signaling and Cancer*

A mathematical model is presented to study the dynamics of the docking protein Gab1 that plays an important role in the regulation of ERK and AKT signaling pathways. Model predictions can be used to understand the role of Gab1 in the development of cancer which can give insight into targeted therapy.