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Kinetics of antibody response in unprimed recipients after transfer of immune lymphocytes.

Spleen cells from mice immunized with SRBC were transferred, at various times after immunization, to non-irradiated and lethally irradiated syngeneic recipients. The PFC kinetics and anti-SRBC antibody titres were followed in various groups of mice. Similar results were obtained both in non-irradiated and lethally irradiated recipients, showing that after the transfer: a) PFC proliferation was blocked, b) PFC blocking was unrelated to their maturation stage, c) resting PFC were still able to synthesize antibodies, d) blocking activity was radio-resistant.