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An Analysis of a Severe Neck Pain Experienced in a Polymyositis Patient

Following a twisting strain with immediate pain in the neck of a polymyositis patient we detail the analysis of a specific range of data gathered before and after the event. The results reinforce that in this case that the creatine kinase isoenzyme and cardiac Troponin T cannot be used as an indicator of myocardial disease.


INTRODUCTION
Recently we published a research [1] that described an analysis of the creatine kinase isoenzyme and cardiac troponin T levels in a polymyositis patient. From an extensive model developed to interpret physiological processes we were able to show that the observed elevated creatine kinase-myoglobin (CK-MB) and serum concentration of cardiac troponin T (cTnT) values for a particular patient are associated with the inflammatory disease, polymyositis and not only myocardial injury. The analysis is focussed particularly on period (i) 27  On 30 March our patient experienced a twisting strain with immediate pain in the neck due to attempting to shift a heavy object whilst sitting; the patient also suffered breathing problems ie. with only very shallow breathing being possible as well as great difficulty in swallowing. The following morning the pain was so severe that an osteopath was consulted. Following a clinical examination of the neck a diagnosis was made of an acute somatic dysfunction of the right cervico-thoracic joint complex, with severe pain over branches of regional nerves, including the brachial and long thoracic nerves with associated protective muscle spasm. This spasm was considered to be caused either by muscle inflammation and or zyapophysial facet joint possible synovitis.
The response to mobilising treatment with massage of the posterior neck muscles on two occasions by the osteopath was significant and rapid relief followed with a gradual resolution of pain over one to two weeks.

MATERIALS AND METHODS
After many years of research, we developed a way to determine the appropriate drug regimen to minimize muscle damage in a particular polymyositis patient [1] . This regimen was adopted in 2001 that included 62.5 mg prednisolone every second day, 2 mg of odrik (trandolapril) and three natural products by Mannatech, namely, 450 mg Ambrotose, three Plus tablets and one PhytAloe tablet per day.
Systolic pressure, diastolic pressure and heart rate were measured on a daily basis. Prednisolone was administered in the morning of day one and blood pressure and heart rate were recorded 12 hrs later and then 36 hrs later on day 2.
Erythrocyte sedimentation rate (ESR), serum creatine kinase (CK), creatine kinase isoenzyme myocardium (CK-MB) and cardiac troponin T (cTnT) were recorded every six weeks by the Queensland Medical Laboratories.
From the 1 Jan 2001 to 31 Dec 2007 the patient's mean systolic pressure, over this period, was 144.74±10.49 mmHg, mean diastolic pressure was 79.25±6.58 mmHg and the mean pulse pressure was 65.49± 9.21 mmHg.
The heart rate results for day 1 and day 2, over the same period, are for day 1 are 92.09 ± 8.50 per min and for day 2 79.03 ± 7.95 per min. Although there are variations within the day 1 and day 2 values, the average difference, on a yearly basis, is a constant of 13.07 ± 1.22 per min. This reinforces that we have no evidence of any changes taking place prior to this study.
By contrast to the previous study [1] , we shall be focussing on a limited range of data from the 14 Jan 2008 to the 30 Jun 2008.

RESULTS AND DISCUSSION
To explore the effect further, we shall examine the ESR, CK, CK-MB and Troponin T levels gathered in 2008 before and after the 30 March 2008 incident. The results are shown in Table 1.
From Table 1 we note the major changes that occurred following the neck problem in the ESR, CK-MB and Troponin T values.
We note the significant increase in the cardiac troponin T levels recorded on 7 April 2008. The systolic pressure and the diastolic pressure from 1 Jan 2008 are shown in Fig. 1.
The mean systolic pressure and the mean diastolic pressure are 141.66±7.42 mmHg and 77.01±4.82 mmHg respectively. The pulse pressure is 64.64±6.86 mmHg. This agrees with the results in period (i) in the CK-MB and Trononin T paper [1] . In other words, no change was observed for the mean systolic and the mean diastolic pressures.
On the other hand, the difference between the heart rate measured on day 1 and 2 following the prednisolone intake was significantly changed as shown in Fig. 2. The difference between the heart rate measured on day 1 and 2 following the prednisolone intake was reduced to zero following the neck problem but returned to normal within 17 days. Neglecting the results over these seventeen days yields for day 1 a mean of 94.03±5.57 min −1 and for day 2 a mean of 78.97±4.87 min −1 . These values agree with those given in the CK-MB and Troponin T paper [1] .  The greatly reduced CK-MB value may be due to the significantly decreased chest muscle activity during the period of shallow breathing, as it is known that chest muscles have more CK-MB than other muscles [2] , thus the decreased chest muscle activity may have lowered the CK-MB level.
The daily variation of the systolic and diastolic pressures has not changed as would be expected with a skeletal muscle problem.

CONCLUSION
In summary, our data, following the twisting strain injury of the neck, appear to reinforce the finding that for patients with skeletal muscle diseases such as polymyositis the plasma levels of the creatine kinase isoenzyme and cardiac troponin T cannot be used as an indicator of myocardial disease.