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A Potentially Deleterious Role of IGFBP‐2 on Bone Density in Aging Men and Women

The role of the IGFs and IGFBPs on age‐related changes in BMD in adult men and women is not well understood. Studying an age‐stratified community based sample of 344 men and 276 women, we found higher IGFBP‐2 levels to be associated with lower BMD. IGFBP‐2, which increases with age in both men and women, was the strongest, most consistent predictor of BMD among the IGF/IGFBPs studied.