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Special issue dedicated to Chad Mirkin: 20 years of influential research.

Nanotechnology is a rapidly evolving and dynamic fi eld, with explosive growth occurring over the past twenty years. Chad Mirkin has been at the forefront of this discipline over this period, making key contributions in a number of areas including nanofabrication, therapeutics, and diagnostics. Chad Mirkin started his research group at Northwestern University in 1991, focusing initially on surface assembly. Soon after, he began his research in the area of nanoparticles, a research theme that is still going strong in his group. This research has spanned the gamut from his initial fundamental studies on nucleotide-mediated particle assembly through to the development of DNAbased diagnostics that are now in the clinic. This research has broadened more recently to include therapeutics and theragnostics, extending the theme of nucleic acid–nanoparticle systems to new spheres of nanomedicine.