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EXERCISE STUDIES IN CHILDREN WITH TRANSPOSITION OF THE GREAT ARTERIES(TGA) AFTER MUSTARD REPAIR

The cardiopulmonary responses to exercise of 17 pts (mean age 13y, M/F=11/6) with TGA and Mustard repair(mean age at surgery=19.4 mo) were compared with those of 17 age-matched normal subjects. An incremental exercise test was performed to determine work capacity (Wmax). Heart rate (HR), oxygen saturation (SaO2), oxygen consumption (VO2) and minute ventilation (VE) were measured during exercise. Cardiac output(Q) and stroke volume (SV) were subsequently computed during steady state exercise at 50% Wmax by the Indirect Fick (CO2) method, and expressed as a % predicted. During the incremental test, the TGA patients, as compared to the normal subjects, achieved lower.maximal values for Wmax, HR, and VO2, but not for VE (Table).During steady state exercise the mean ± SD values achieved by the TGA patients for Q and SV were 10.4 ± 1.7 L/min (92 ± 2 % pred) and 66 ± 14.5 mis (98 ± 16 % pred) respectively. We conclude that the aerobic capacity of TGA patients following Mustard repair is significantly reduced.