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[The oxidation resistance of heparin-precipitated blood serum beta-lipoproteins in ischemic heart disease].

Oxidative modification of low-density lipoproteins plays the key role in the pathogenesis of atherosclerosis. The purpose of this study was to assess oxidation resistance of serum beta-lipoproteins (beta-LP) in coronary patients in comparison with normal subjects by a simple method. The study was carried out in 37 male patients with coronary disease and type IIb dyslipoproteinemia and 48 healthy men with normolipidemia. beta-LP was isolated by precipitation in the presence of heparin. The initial level of lipid peroxides in them and their oxidation resistance during incubation in the presence of 50 microM cooper ions were assessed. The baseline content of lipid peroxides in beta-LP was two-fold increased and oxidation resistance two-fold decreased in coronary patients as against normal controls. Oxidation resistance of precipitated beta-LP in coronary patients and normal subjects was different.