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Understanding depression: the hippocampus might hold the answer in a CREB‐regulated transcription coactivator

The pathophysiology of major depressive disorders is not completely understood. In this issue of Journal of Neurochemistry, Ni and colleagues investigate the role of cyclic adenosine monophosphate response element‐binding protein (CREB)‐dependent signaling in the hippocampus on depressive‐like behaviors. This editorial highlights the key findings reported by Ni et al., (2018) and how they demonstrated the importance of CREB‐regulated transcription cofactor 1 in LPS‐induced neuroinflammation and depressive‐like behaviors.