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DNA synthesis in autonomous and hormone-responsive mammary tumors.

Summary Hormone responsiveness of autonomous and diversely hormone-responsive mammary tumors of the rat was assayed in organ cultures by measuring DNA synthesis. Rat sera rich in hormones secreted by mammotropic pituitary cells were compared with sera of normal female and male and of ovariectomized and hypophysectomized rats. Mammotropic sera invariably stimulated DNA synthesis of hormone-responsive tumors and normal mammary glands but not of autonomous tumors.