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Annexin II overexpression correlates with stromal tenascin‐C overexpression

Overexpression of annexin II, a calcium‐dependent phospholipid‐binding protein, has been reported in various carcinomas. One of its ligands is tenascin‐C, an extracellular matrix glycoprotein with predominantly antiadhesive qualities that also has been reported to be a prognostic marker for several carcinomas. In the current study, the authors investigated the correlation between the overexpression of annexin II and tenascin‐C in colorectal carcinoma.