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Conformation of cyclic analogs of enkephalin. III. Effect of varying ring size

A comparative study has been made using molecular mechanics of the ring entity of the active enkephalin analogs, Tyr‐cyclo(‐Nω‐D‐XXX‐Gly‐Phe‐Leu‐), where XXX is variously A2pr, A2bu, and Orn. Several conformations are favored for all three, and the lower‐energy models are compatible with a Gly3‐Phe4 bend in the active form of enkephalin. Some difficulties in assuming standard geometries in conformational surveys are illustrated.