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Change of IL-6 in Lyme Arthritis Induced by Bmp A of Borrelia burgdorferi

Objective To investigate the change of IL-6 in Lyme arthritis. Methods Twenty female Kunming mice were selected and randomly divided into two groups. The recombinant Bmp A of Borrelia burgdorferi was injected into the tibiotarsal joint of experimental group mice to induce the arthritis. ELISA experiment was used to detect the concentration of IL-6 in murine joints. Results The average concentration of IL-6 in the joint fluid of experimental mice and normal control group was 72.26 pg/m L and 31.32 pg/m L, respectively. The difference was statistically significant between two groups(P 0.01). Conclusion IL-6 is a important inflammatory cytokine,it has obvious correlation with Lyme arthritis.