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Mediators of Employment Status and Depression in Multiple Sclerosis

The current study examined possible reasons underlying the relationship between depression and job status in MS patients. Given that prior work has shown that stress, maladaptive coping strategies, and low levels of social support are associated with depression in MS, differences between work status groups on these variables was explored. Participants for the proposed study were thus divided into three groups: patients who work full-time, cut back on their work hours because of MS, and had to quit working due to MS symptoms. Differences between groups on measures of stress, coping, and social support were explored. Mediators of Employment Status and Depression in Multiple Sclerosis Multiple Sclerosis is a disease that affects the central nervous system (CNS), which consists of the brain, spinal cord, and optic nerves. Everything we do, whether it is taking a step, solving a problem, or simply breathing, rely on the proper functioning of the CNS. In the brain, millions of nerve cells, called neurons, continually send and receive signals. Normally, the path in which the nerve signal travels is protected by a type of insulation called the myelin sheath. The myelin sheath is a fatty substance that surrounds and protects the nerve fibers. This insulation is essential for nerve signals to reach their target. In MS, the myelin sheath is destroyed, scar tissue forms (sclerosis) and the underlying wire-like nerve fiber is also damaged. This leads to a breakdown in the ability of the nerve cell to transmit signals. It is believed that the loss of myelin is the