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Are ALK rearrangements found in smooth muscle tumours of the gastrointestinal tract?

Leiomyomas of the gastrointestinal tract are benign smooth muscle tumors which can arise in the esophagus, stomach, small intestine and colon with the esophagus being the most common site. They are most often solitary and can arise from either the muscularis mucosae or the muscularis propria. Tumors less than 5 cm are usually asymptomatic while larger tumors can cause symptoms. ALK rearrangements carrying a FN1-ALK fusion gene have been described in two gastrointestinal leiomyomas. (1) This study was undertaken to confirm if gastrointestinal leiomyomas harbored ALK rearrangements and the frequency of this event.