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Role of oxidative stress and inflammatory cytokines in Type 2 Diabetes Mellitus patients with and without small intestinal bacterial overgrowth

In type 2 diabetes mellitus (T2DM), insufficient insulin or resistance to insulin in body results in reduced uptake of glucose causing hyperglycemia. This may lead to oxidative stress and further may increase cytokine production. Inflammation may affect gut neural apparatus that may lead to gastrointestinal dysmotility which may amplify occurrence of small intestinal bacterial overgrowth in these patients.