{'fraction_non_alphanumeric': 0.04205946337926034, 'fraction_numerical': 0.014503263234227702, 'mean_word_length': 5.330275229357798, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
A LONGITUDINAL STUDY OF PUBERTY IN BOYS

A prospective study, designed to correlate serial measurements of tropic and end organ hormone levels with the physical changes of puberty, was carried out in 46 boys with physical examinations and blood samples every 6 months for 4 years. Serum levels of LH, FSH, prolactin, testosterone (T), andro-stenedione, dehydroepiandrosterone (DHA), DHA sulfate, progesterone (P), 17 OH-P, estrone, and estradiol were determined and correlated with genital and pubic hair staging criteria, appearance of axillary hair, facial hair, voice change, acne, pubertal gynecomastia, weight gain, and height increase.Significant correlations were: (1) parallel increases of LH and T throughout puberty after an initial rise of LH; (2) FSH increases during early puberty; and (3) androstenedione, DHA, and DHAS increase throughout. Prolactin levels did not change. Concentrations of 17-OH-P increased while P levels rose minimally. The 80% who developed acne had significantly higher T levels than stage-matched controls. Subareolar breast hyperplasia occurred in 68% concomitant with a rise of T occurring with minimal increases of estrogen. The onset of facial hair, axillary hair, voice change, and increased weight and height are more closely correlated with increasing T levels than changes in other hormone levels. (Supported in part by NIH-HD-05318)