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Fibrin stabilization, factor XIII transamidase activity and subunits "A" and "B" concentration in plasma of patients with liver cirrhosis.

The parameters found in the last phase of blood clotting were measured in patients with liver cirrhosis against a background of some coagulation and fibrinolysis tests. The significant decrease of the fibrin stabilizing activity of plasma and the fall of plasma free -SH groups concentration were documented in the patients. It was accompanied by impaired whole blood clot elasticity in the thrombelastogram. Cirrhotic patients also revealed diminished factor XIII transamidase activity as well as decreased concentrations of its subunits "A" and "B". The data emphasize the necessity of factor XIII substitution and -SH groups supplement in patients with liver cirrhosis.