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Study on the relationship between the expression of S100A12, CaSR, and IL-7R in the synovium of knee osteoarthritis and angiogenesis.

BACKGROUND
To analyze the relationship between the expression of calcium binding protein (S100A12), calcium sensitive receptor (CaSR), and interleukin-7 receptor (IL-7R) in the synovium of knee osteoarthritis (KOA) and angiogenesis.


METHODS
The clinical data of 92 patients with KOA admitted to Sichuan Provincial People's Hospital from February 2019 to May 2020 were collected (KOA group, Kellgren-Lawrence staging: 23 cases of grade 2, 49 cases of grade 3, and 20 cases of grade 4). In addition, 87 cases of patients with normal knee cartilage that were not involved during the same period of treatment in this hospital were selected. The expressions of S100A12, CaSR, IL-7R, and microvascular density (MVD) were compared among different populations, and the correlation between S100A12, CaSR, IL-7R, and MVD, and its diagnostic value for KOA were analyzed.


RESULTS
The values of S100A12, CaSR, IL-7R, and MVD in the KOA group were significantly higher than those in the control group (P<0.05); the values of S100A12, CaSR, and IL-7R in grade 4 patients were significantly higher than those in grade 2 and 3 patients (P<0.05); S100A12, CaSR, IL-7R, and MVD were all positively correlated, and the difference was statistically significant (P<0.05). According to the receiver operating characteristic (ROC) curve, the area under the curve (AUC) of S100A12, CaSR, and IL-7R for KOA diagnosis was 0.982, 0.929, and 0.899, respectively. The Youden index was 0.630, 0.835, 0.739, respectively.


CONCLUSIONS
The expression levels of S100A12, CaSR, and IL-7R in the synovium of KOA are significantly up-regulated, and they are closely related to angiogenesis.