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Changes in interleukin‐6 levels during electroconvulsive therapy may reflect the therapeutic response in major depression

Interleukin‐6 (IL‐6) has been reported to be elevated in major depressive disorder (MDD) but decreased by antidepressive medication. IL‐6 levels are markedly elevated both after epileptic seizures and single electroconvulsive therapy (ECT) session, but long‐term changes in IL‐6 levels after ECT have not been studied. The correlation between immediate and long‐term changes in proinflammatory cytokines and outcome after ECT was investigated.