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A New Methodology to Prepare 2-Halogenoimidazoles via a N-THP Protection

A straightforward access to 2-halogenoimidazoles via a N-THP protection was described in this paper. The NTHP protecting group is easily introduced by reaction of 2-chloro-THP with imidazole. Lithiation followed by reaction with an appropriate electrophile affords 2-halogeno N-THP derivatives. The THP protecting group is then cleaved to get the title compounds in good to high yields.