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The interaction between NGF‐induced hyperalgesia and acid‐provoked pain in the infrapatellar fat pad and tibialis anterior muscle of healthy volunteers

Tissue pH is lowered in inflamed tissues, and the increased proton concentration activates acid‐sensing ion channels (ASICs), contributing to pain and hyperalgesia. ASICs can be upregulated by nerve growth factor (NGF). The aim of this study was to investigate two new human experimental pain models combining NGF‐ and acid‐induced pain in a randomized, controlled, double‐blind study.