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Anti-cancer activity of ethanolic extract of Jackfruit (Artocarpus heterophyllus) skin on human melanoma and colon cancer cell lines

The objective is to find out whether the ethanolic extract of Jackfruit skin has anticancer activity against human melanoma and colon cancer cell lines. The ethanolic extract of Jackfruit skin (EEJS) was prepared by maceration and filtration technique. The human melanoma (A-431) and colon cancer(HT-29) cell lines were procured from NCCS (National Centre for Cell Science), Pune, India and grown in DMEM (Dulbecco’s Modified Eagle Medium). Anti-cancer activity of EEJS was evaluated in-vitro by MTT (3-(4,5-dimethylthiazolyl-2)-2,5diphenyltetrazolium bromide)and LDH (Lactate dehydrogenase) assays in six different concentrations 0.5, 1, 2, 4, 8 and 12mg/ml against these two cell lines. The yield of the extract was 3.08%. EEJS exhibited cytotoxicityin all the doses and a maximum of 93% and 90% was observed at 12mg/ml againstA-431 cell lines in MTT and LDH assays respectively. The anti-colon cancer activity was 39% and 38% in both the assays. The anti-cancer activity was found to be higher for melanoma than colon cancer cell lines. EEJS showed cytotoxicity against human melanoma and colon cancer cell lines and the cytotoxicity was highly significant against melanoma than colon cancer cell lines.