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[Lomefloxacin concentration in human prostatic tissue following 3-day administration].

The penetration of Lomefloxacin (LFLX) into the prostatic tissue and the serum were examined. Forty four patients with benign prostatic hypertrophy treated with transurethral resection of the prostate (TUR-P) were entered in this study. LFLX was administered orally in a dose of 200 mg three times daily for three days preoperatively. The blood samples were taken simultaneously at the time of the tissue sampling. The patients were divided into groups 1 and 2. In group 1 (seventeen patients), the tissue sampling was done about 17 hours after the final drug administration. The mean concentration of LFLX was 3.31 +/- 1.16 micrograms/g in the prostatic tissue and 1.70 +/- 0.56 micrograms/ml in the serum. In group 2 (twenty seven patients), tissue sampling was done 5.5 hours after the final drug administration. The mean concentration of LFLX was 5.70 +/- 2.28 micrograms/g in the prostatic tissue and 2.93 +/- 1.14 micrograms/ml in the serum.