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Multiple Primary Synchronous Gastric, Esophageal, and Rectal Cancer and Isolated Esophageal Metastasis from Rectal Cancer: Case Report

neoplasms identified simultaneously or within 6 months after the initial diagnosis in the same patient.1 However, synchronous tumors of the gastric and rectum carcinoma are not infrequent; particularly in the elderly male patient.2 The most commonly detected synchronous tumors in patients with gastric cancer are colorectal cancers, which are followed by lung, esophagus, and liver cancers.2 Rectal carcinoma commonly metastasizes to the liver, lungs, bone, brain, and lymph nodes.3 Esophageal metastasis of rectal carcinoma is an unusual occurrence owing to its rarity and challenges in diagnosis. Therefore, patients might be misdiagnosed sometimes and not be treated properly. Secondary carcinoma of the esophagus occurs as a result of the direct invasion, hematogenous, or lymphatic spread from the distant primary sites.4 Approximately 3.1-6.1% of patients who had died from any type of cancer in the autopsy series reported esophageal metastasis. Additionally, it has shown that the most common primary malignancies that metastasize to the esophagus are breast and lung cancers in the same autopsy series.3,5 Herein, we present the case of a 63-year-old man with synchronous gastric, rectal carcinoma, and in situ esophageal carcinoma who also had isolated esophageal metastasis from rectal carcinoma. J Oncol Sci. 2021;7(3):159-62