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Cytotoxic and Genotoxic Effects of 10 N-Nitroso Compounds in a Human Hepatoma Cell Line (Hep G2): Comparison with Human Hepatocyte Primary Cultures

A comparison of data from assays performed in cells of an established line derived from a human hepatoblastoma (Hep G2) with those previously obtained in freshly-isolated human hepatocytes, reveals that the latter are, by varying degrees, more sensitive than the former to the cytotoxic and genotoxic effects of 10 N-nitroso compounds, independently of their nature as proximate or ultimate carcinogens.