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Alterations of cortical thickness and gray‐white matter contrast in Alzheimer’s disease and Lewy body‐related cognitive impairment

Gray and white matter alteration has been known in patients with neurodegenerative diseases including Alzheimer’s disease‐ (ADCI) and Lewy body‐related cognitive impairment (LBCI). We examined a distinct pattern of cortical thickness (CTH) and gray‐white matter contrast (GWC) alterations in these degenerative neurological diseases. Since the T1‐weighted MRI signal is closely related to myelin content, the GWC may reflect disease‐related alterations of myeloarchitecture along the cortical surface.