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EFFECT OF VEHICLE ON PILOCARPINE‐INDUCED MIOSIS

To determine the effect of 1.4% polyvinyl alcohol (PVA) and castor oil vehicles on the pilocarpine‐induced miosis, we studied the miotic effect of 2% pilocarpine‐PVA and oily drops on 4 young and 10 elderly people and the miotic effect of 4 % pilocarpine‐PVA and oily drops on 13 elderly people. The miosis developed fast within 15 min, and maximum miosis was rached within 1 h. Oily drops of pilocarpine induced stronger maximum miosis than corresponding PVA‐drops. The pupil remained contracted to less than 50 % of its starting diameter after pilocarpine‐PVA drops for 3–4 h and after oily drops for 9 h and returned to its starting diameter after pilocarpine‐PVA drops 9–10 h and after oily drops 20–24 h following administration. The difference in the effect between pilocarpine‐PVA and oily drops was independent of the subjects' age.