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Urinary iodine in second trimester of pregnancy: A cross sectional study in tertiary care hospital of Belagavi

Submission: 17-06-2020 Revision: 23-07-2020 Publication: 01-09-2020 Address for Correspondence: Bibek Basnet, Post Graduate Student, Department of Biochemistry, KLE Academy of Higher Education and Research, Jawaharlal Nehru Medical College, Belagavi, Karnataka, India. Mobile Number: +977-9862111117. E-mail: bibekbasnet42@gmail.com Background: Iodine is a nutritionally important trace element and its deficiency is a common health problem affecting a huge population, particularly pregnant women and children. The physiological role of iodine in the human body is synthesis of thyroid hormones. Thyroxine is approximately 60% iodine by weight. If iodine intake falls below approximately 100μg/day, Thyroid Stimulating Hormone (TSH) secretion is augmented, which increases plasma inorganic iodide clearance. Aims and Objective: To correlate urinary iodine with serum TSH in the second trimester of pregnant women. Materials and Methods: One hundred five subjects were included in the study from tertiary care hospital. A random urine sample was collected. Iodine was estimated by ammonium persulfate method and TSH values were collected from the OBG department of the subjects enrolled. Statistics: Pearson correlation coefficient was done. Results: Median UI 138.50 (29.80-350.51) μg/L, median TSH 1.90(0.17-7.46) mIU/L. There was no significant correlation between UI and serum TSH with r = (0.0873, (p = 0.3756). Conclusion: Urinary iodine is a marker for population iodine status. A preferable biomarker is necessary to know the iodine status of individual which include not only nutritional biomarker and also required to organise reference range for TSH.