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Resistance potential of certain breeds of domestic fowl exposed to Raillietina tetragona infections. 8. Effect of thiouracil on R. tetragona infections.

Abstract Daily administration of 0.1% thiouracil [4(6) methyl-2 thiouracil Fluka AG] along with the feed to twenty 2-week old chickens belonging to four breeds for a period of six weeks (in a study involving 60 birds) showed no significant effect on the fowl-R. tetragona relationship. We found that the drug has neither lowered nor increased resistance of chickens to this cestode infection. In all the experimental birds, the thyroid gland was enlarged 3–10 times due to hypertrophy and hyperplasia. Hypertrophic changes of thyroid gland and a decrease in leucocyte values observed in infected controls were aggravated in most of the drug-treated experimentals. Breed difference was clearly noticed as regards worm development, haemoglobin values, weight of worms and thyroid glands and percentage of body weight gains in host birds.