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[Curve of labeled mitoses with different states of cell proliferation kinetics. V. Effect of the circadian rhythm of cell proliferation on the shape of the labeled mitosis curve].

The influence of the diurnal rhythm in cell proliferation processes on the behavior of labeled mitoses curve (LMC) is under investigation. The mathematical model predicts that LMC observed following 3H-thymidine administration to experimental animals at different day-times can differ greatly even when temporal parameters of the mitotic cycle remain unchanged. The analysis of the experimental data on the hamster's cheek pouch epithelium suggests that diurnal differences in LMCs cannot be explained in certain cases by the influences of transient processes in cell kinetics only, and therefore the existence of a slight trend in prolongation of periods of the mitotic cycle cannot be completely excluded.