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Cutaneous calcinosis in a patient with limited scleroderma: CREST Syndrome.

Cutaneous calcinosis in a patient with limited scleroderma: CREST Syndrome Calcinosis or dystrophic soft-tissue calcification occurs in damaged or devitalized tissues in the presence of normal calcium/phosphorus metabolism. It is a known manifestation in the subcutaneous tissues of patients with connective tissues diseases, especially scleroderma, systemic lupus erythematosus, or dermatomyositis, and may involve a relatively localized areas or present as widespread calcinosis (1). Little is known about its physiopathology. It occurs in tissues that are under chronic stress, such as local trauma or damage associated with underlying inflammatory processes (2).