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The TALLYHO Mouse as a Model of Obesity‐Induced Linear Growth Acceleration

Obesity affects over 30% of adults in the United States and contributes to development of painful conditions such limb bowing, joint instability, increased risk of fractures, and early onset osteoarthritis. Nearly one third of American children are now classified as overweight or obese and are at risk of developing musculoskeletal complications because of stress from excess weight on their growing skeleton. Obese children have higher rates of linear growth and accelerated skeletal maturation when compared to their non‐obese peers. They tend to reach maturity earlier and thus typically attain normal adult height, but with diminished bone quality. It is unclear why obese children exhibit increased growth velocity. Among the animal models used in obesity research, the TALLYHO/Jng (TH) mouse is an inbred polygenic model that exhibits moderate obesity by 4‐weeks age and many of the traits consistent with human type 2 diabetes. While the physiology and genomics of the TH strain are well documented, little is known about its skeletal phenotype.