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Estrogen excretion of the pregnant baboon (Papio papio).

A radioimmunoassay for determination of urinary estrone (E1)1 excretion from pregnant baboons has been devised. Conjugates were hydrolyzed enzymically and E1 was extracted with diethyl ether. Following isolation by Sephadex LH-20 chromatography, E1 was assayed by competition with 3H-E1 for an estradiol-17β-BSA conjugate antiserum. During the 5 days after iv administration of 2.5 and 5.0 mg estradiol-17β to pregnant animals the increments in urinary E1 represented 52 and 57% of the dose, respectively, and thus supported our estimate of E1 excretion. E1 values in urine of nonpregnant animals were <15 µg/24 hr. Mean E, (μg/24 hr) excretion by 6 pregnant animals determined at 5-day intervals rose from 320 at 70 days to 640 at 175 days gestation. Daily determinations thereafter showed a further rise to 840 at term (184 days). Between 70 and 175 days the rate of increase of urinary E1 excretion was 3.0 ± 0.5 (SE) µ,g/24 hr and significantly different (p = < 0.01) from that during the final 9 days of gestation (...