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Pregabalin Induced Maculopapular Eruption in an Elderly Male.

Pregabalin is used in the treatment of neuropathic pain of various etiologies and as adjuvant in epilepsy. Blockade of the α2δ subunit of L and N type Ca-channels is its main mechanism of neurotropic action. Compared to other antiepileptics like phenytoin, valproate and lamotrigine, and other neuropathic pain medications such as amitriptyline and duloxetine, pregabalin has a relatively favorable safety profile and hence is a drug of choice for many geriatricians. Here we describe a case of maculopapular rash induced by pregabalin in an elderly man which resolved with withdrawal of the offending drug and conservative management. We have also conducted a literature review of similar cases and highlight the clinical patterns and management strategies for pregabalin induced skin rashes.