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Lung Parenchymal Changes Due to Ingested Substances

by Liebow & Carrington (1969). This illness, characterized by fever, loss of weight, sweats, cough and pulmonary consolidation, may be induced by the exhibition of drugs. A recent account in The Lancet (1974) describes several cases following prolonged uses of suiphasalazine. Carrington et al. (1969) have described a characteristic X-ray picture, with dense peripheral opacities, the hilar region remaining clear. The histological picture is that of pneumonic consolidation, with the eosinophil as the leukocyte filling alveoli and interstitial tissues and without arterial disease. However, biopsy should rarely be needed because the illness is always accompanied by a blood eosinophilia. Of two patients with eosinophilic pneumonia of the chronic severe type, which may have been caused by the exhibition of sulphonamides, one was cured by the exhibition of high dosage steroids for a relatively short time; the other improved but showed evidence of permanent lung damage.