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Effect of 17β-oestradiol and ginsenoside on osteoporosis in ovariectomised rats

To study the anti-osteoporosis effects and mechanism of action of oestradiol (E2) and ginsenoside (tR), we measured the bone mineral densities (BMD) of lumbar vertebra and tibia and analysed the tibia histological morphological data, as well observed the activity and the number of osteoblasts and the activity of alkaline phosphatase (ALP) and the concentration of cAMP. Results showed that E2 (400 μg kg− 1 week− 1) and tR (10, 20, 30 mg kg− 1 day− 1) were able to countervail the decreasing in BMDs of lumbar vertebra and tibia induced by OVX in rats (P < 0.05); E2 (0.1 μmol l− 1) and ginsenoside Rg1 (1 μmol l− 1 and 10 μmol l− 1) were able to increase the number of osteoblasts, the activity of ALP and the concentration of intercellular cAMP in cultured osteoblast cells. The present findings suggest that E2 and tR have an anti-osteoporosis effect in ovariectomised rats.