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MRI‐guided radiofrequency ablation of breast cancer: Preliminary clinical experience

This study was designed to demonstrate the feasibility of MRI‐guided radiofrequency ablation (RFA) of breast cancer. A total of three women diagnosed with invasive ductal breast cancer were treated with percutaneous MRI‐guided RFA, according to a treat and resect protocol, in our hospital. RFA procedures were performed in an open 0.5T Signa‐SP imager allowing direct patient access and real‐time monitoring of the procedure. In all patients ablation was performed with a 15‐gauge insulated MRI‐compatible multiple needle probe. MRI thermometry and contrast‐enhanced postablation MRI were used to evaluate the ablation process. Patients underwent lumpectomy within a week of the RFA procedure. Histopathology confirmed successful (100%) tumor ablation in one patient, and partial tumor destruction (33% and 50%, respectively) in two patients. Challenges of MRI‐guided breast RFA that need to be solved to facilitate progress of the technique toward clinical practice are discussed. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.