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Deciphering Role of Cytokines for Therapeutic Strategies Against Rheumatoid Arthritis.

Rheumatoid Arthritis (RA) is a systemic, chronic, autoimmune, inflammatory disorder which affects of the both large and small synovial joints in a symmetric pattern. RA initiates as painful inflammation of the joints leading to stiffness of joint, joint destruction and further worsens the condition causing permanent irreversible damage to the joints making them physically disabled. Across the globe, there are around 1.2 million cases of RA reported. Inspite of various available therapeutic and pharmacological agents against RA, none of the treatment assure complete cure. Understanding the in depthrole of cytokines and interleukins in disease pathogenesis of RA could help in exploiting them for developing novel therapeutic strategies against RA. This review provides insights into pathogenesis of RA and gives a brief overview of cytokines which play an important role in the progression of the disease. We have also discussed possible role of interleukins in context of RA which could help future researchers to explore them for identifying new therapeutic agents.