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Bacterial resistance to streptothricins

Resistance to streptothricin was studied in bacteria with different resistance mechanisms. The laboratory‐induced streptothricin‐resistant mutant E. coli A19 Stcr 2/2/1 showed a high level of cross‐resistance to aminoglycosides and other miscoding inducing antibiotics. In contrast, amino‐glycosid‐resistant E. coli strains with plasmid‐determined aminoglycoside modifying enzymes were sensitive to streptothricin. Enzymatic inactivation of streptothricin by acetylation was demonstrated for the streptothricin producing Streptomyces noursei, strain NG13. This strain showed no cross‐resistance to miscoding inducing aminoglycosides.