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Assessment of glomerular filtration rate by means of the three-compartment closed model after a single intravenous injection.

The two-compartment open model is currently used to assess glomerular filtration rate (GFR) with multiple blood samples. Numerous limited sampling models have been developed to reduce the number of blood samples. In the present study, the three-compartment closed model was used to assess GFR after a single intravenous injection. The three-compartment closed model includes blood, peripheral and urine compartments, thus the samples in urine can be used to estimate parts of pharmacokinetic parameters, thus to reduce the number of blood samples. Theoretically, the three-compartment closed model can assess GFR with one blood sample at any sampling time and three urine samples at any three sampling times.