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IDDF2019-ABS-0107 Clinical profile and outcome of acute pancreatitis in children admitted in philippine children’s medical center

Background Acute pancreatitis, once considered rare in children, has been reported to show an increasing incidence worldwide. Determining Philippine data on clinical profile, factors, severity and outcome would help improve the recognition, diagnosis and management of this emerging disease. To determine the clinical profile of children with Acute Pancreatitis and the factors associated with their outcome and severity. Methods A retrospective cohort study was done on children 0–18 years old with a diagnosis of Acute Pancreatitis. Demographic, clinical and diagnostic data gathered were compared among severity classification and outcome. Results Thirty-five cases were identified in a period of 18 years, but only 28 cases were reviewed. Mean age was 11.5 years old ± 4.1 SD (range 4 - 18) with slight male predominance. Ninety-three percent presented with abdominal pain. Most common etiology was idiopathic (44%), followed by biliary disease and infection (21% each). Gallstones and choledochal cyst post excision were the most common of the co-morbidities seen. Most common imaging findings was that of an edematous or enlarged pancreas. Five cases of acute recurrent pancreatitis noted. Most common local complications seen were pseudocyst formation and fluid collection with 11% each. One death was due to hemorrhagic pancreatitis seen intraoperatively. Of the factors reviewed, gallstones and the 3–10 years old age group were found have a statistically significant difference in terms of having a mild vs non-mild severity classification and type of clinical outcome on discharge, respectively. Conclusions In this study, gallstones and age group of 3–10 years are found to affect severity and outcome and should be considered closely during management of pediatric acute pancreatitis. A multi-center study on the incidence and clinical profile and outcome is recommended to obtain a better picture of the acute pancreatitis in Filipino children to help clinicians in recognizing and decreasing the morbidity and mortality of this disease.