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Interleukin 1 in the in Vitro Antigen‐Induced Antibody Response in the Human Adult and Newborn

Previous studies have shown that in vitro stimulation of human B lymphocytes with antigens such as ovalbumin (OA) induces the Formation of small antigen‐specific plaque‐forming cells (PFC) but precludes the activation of the B cells into full‐blown antibody‐secreting cells insufficient production of T cell‐derived growth and differentiation factors appears to be the basis of the phenomenon. Furthermore, cord blood B lymphocytes required 100 limes less OA to become activated in vitro into antigen‐specific PFC, and the distinct antigen‐handling capacities of neonatal monocytes are the basis of this result. We have studied the role of interleukin 1 (IL‐1) in the in vitro response of B lymphocytes from either cord blood or adult blood to OA. Addition of IL‐1 to the B‐cell cultures significantly increased the number of PFC. and about 50% of the plaques now appeared to be high‐rate IgM anti‐OA secreting PFC. The IL‐1 ‐mediated increase in the PFC response was shown to be based on potentiation of T‐helper cell activity. The differences between cord blood and adult blood mononuclear cells in the optimal OA concentration required for effective in vitro activation of B cells remained the same upon addition of II‐1 This result shows that the phenomenon is independent of IL‐1.