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Numerical investigation of biochemical binding kinetics on the microfluidic chip with FO-LPR

The realization of the biosensing platform could be achieved via the measurement of evanescent wave absorption by the nanoparticle-modified optical fiber. The present microfluidic device was made of polymethylmethacrylate (PMMA) by microinjection molding. The reaction microchannel is 950µm high and 950µm wide with an effective binding length of 18.1 mm. An unclad optical fiber of 400µm in diameter, which was is fixed at the center of the microchannel. A gold nanoparticles monolayer was coated on the unclad portion of the optical fiber. Therefore, receptors were modified on the colloidal gold surface to functionalize the gold surface. The present study was to simulate the biochemical assays in the fiber-optic localized plasma resonance (FO-LPR) microfluidic chip, and to investigate the effects parameters such as inlet concentrations of analyte or the flowrate on the biochemical binding kinetics. The numerical investigation was helpful for the optimization of designing the FO-LPR microfluidic chip.