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EXOCRINE FUNCTION OF THE LIVER IN RATS WITH EXPOSURE TO CОRVITIN.

In acute experiments on rats with cannulated bile duct we
studied the effect of Corvitin, water-soluble analogue of
quercetin, on secretion of bile. Intraportal administration of
the test compound at doses of 2,5; 5 and 10 mg/kg resulted in
a significant increase in the volume of secreted bile by 20,9,
31,2 and 20,4%, respectively, as compared with the control. Using the method of thin layer chromatography it was established
the mild stimulating effect of Corvitin on the processes
of bile acids conjugation with taurine and glycine, especially
when administered at a dose of 5 mg/kg. This flavonoid did not
affect the concentration of glycocholic acid, however increased
the content of glycochenodeoxycholic and glycodeoxycholic
acids in the mixture between 15 to 35,1%. Regarding free bile
acids, the concentration of cholic acid, chenodeoxycholic and
deoxycholic acids in the mixture was increased significantly
relative to control only after Corvitin application at dose 10 mg/
kg. In the first case – from 17,9 to 29,8%, in the second – from
25 to 65,4%. At the dose of 5 mg/kg, Corvitin significantly
increased the ratio of bile cholates conjugation (maximum by
23,2%), whereas 10 mg/kg of the drug decreased this index
by 27,0%. After administration of Corvitin, the hydroxylation
ratio in all experimental groups differed little from the control:
at the dose of 5 and 10 mg/kg this parameter decreased by
14%. Thus, Corvitin modulates exocrine function of the liver,
causing an increase in bile secretion and concentration of
different cholates, dose-dependently increasing or decreasing
the effectiveness of multienzyme systems providing processes
of bile acids conjugation in rats.