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Histological analysis of DuraGen in a human subject: case report.

OBJECT
DuraGen (Integra Neurosciences, Plainsboro, NJ, USA) is an avascular collagen matrix used for dural closure. Although, numerous animal models have been studied, histological transformation of DuraGen in humans has not been reported.


MATERIAL AND METHOD
We analyzed a sample of scarred DuraGen used in a craniectomy patient at time of delayed cranioplasty.


CONCLUSION
Histological analysis revealed evidence for both fibroblast infiltration and neovascularization of the DuraGen.