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Are e-Cigarette Users at an Increased Risk of Bladder and Lung Cancer?


 PurposeElectronic cigarette (e-cigarette) smoking and similar novel smoking modalities have raised questions about their impact on various cancers compared with traditional forms of tobacco smoking. Tobacco smoking has been proven to increase the risk of many cancers, including lung (LCa) and bladder (BCa) cancer. Currently, there is little data on how e-cigarette smoking impacts the incidence of these cancers. We investigated whether any disparities exist in the prevalence of LCa and BCa between various smoking histories using a US nationally representative data source.MethodsThis cross-sectional survey-based US study included men and women aged 18+ from the National Health Interview Survey (NHIS) database between 2016-2018. Primary endpoint was self-reported occurrence of LCa and BCa diagnosis. Multivariable logistic regression analyses assessed possible association of various covariates with diagnosis of these cancers.ResultsPrevalence of BCa and LCa was higher in all smoking histories compared to never smokers. Patients with a history of e-cigarette smoking vs. no history of e-cigarette smoking were significantly younger at BCa diagnosis (56.87 [±9.86] vs. 65.00 [±12.60] years, p=0.001). Multivariable logistic regression models showed that a history of cigarette smoking and e-cigarette smoking individually and exclusively was associated with increased ORs of 2.476 (p=<0.001) and 1.577 (p=<0.001) for BCa diagnosis, respectively, and 4.589 (p=<0.001) and 1.614 (p=0.007) for LCa diagnosis, respectively. ConclusionCompared to never smokers, e-cigarette smoking history was associated with increased risk of LCa and BCa development. Additional studies are needed to better define the public health effects of these novel and unregulated products.