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[Adverse drug reactions in the Spanish medical bibliographic literature: a comparison of 3 periods].

BACKGROUND
A quantitative and qualitative assessment of reports on suspected adverse drug reactions (ARD) in Spanish medical literature was carried out.


MATERIALS AND METHODS
The periods analysed were 1972-1974, 1986-1988 and 1992-1994, and the medical journals were Anales de Medicina Interna, Medicina Clínica and Revista Clínica Española. We selected all articles including specific information on suspect ADR.


RESULTS
The percentage of articles has increased considerably (1972-1974: 2.1%, 1986-1988: 5.7%, and 1992-1994: 8.2%). In spite of this growth, the qualitative data studied have not significantly improved.


CONCLUSIONS
It is necessary to device some mechanism in order to improve ADR reporting.