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A Novel Electrochemical Biosensor based on Layered Hydroxide Nanosheets/DNA Composite for the Determination of Phenformin Hydrochloride

Layered double hydroxides (LDHs) are a kind of lamellar materials, which have been widely developed in electrochemical sensor owing to their excellent properties, such as large specific surface area, unique ion-exchange characteristic and good biocompatibility. In this paper, we reported a novel electrochemical sensor through layer-by-layer self-assembly of ultra-thin LDH nannosheets (LDHNS) and DNA for detecting the phenformin hydrochloride. The voltammetric signal of guanine in DNA/LDNHS hybrid decreases evidently due to the strong interaction between DNA and phenformin hydrochloride. Benefit from the synergic effect of LDHNS and DNA, the electrochemical sensor shows a wide linearity range from 1.0×10 mol·L to 1.0×10 mol·L with a low detection limit of 3.4×10 mol·L. Furthermore, the interaction between phenformin hydrochloride and DNA on modified electrode is also studied by electrochemical method and UV-vis spectroscopy.