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The effect of poloxamer 407 on the functional properties of HDL in mice

Objectives  There is an inverse relationship between high‐density lipoprotein (HDL) and heart disease. HDL possesses not only both antioxidant and anti‐inflammatory properties, but also anti‐thrombotic and endothelial function‐promoting qualities. However, it is not only the serum concentration of HDL that is important, but also the ‘functional’ quality of the HDL. The objective was to determine the functional status of HDL in a well‐established mouse model of dyslipidaemia and atherosclerosis induced by the administration of a block copolymer (poloxamer 407; P‐407).