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COMPLEX ANEUPLOIDY IN AN APPARENTLY NORMAL FEMALE

A 35 year old woman was referred for genetic counseling after delivering a stillborn with multiple congenital anomalies. Thirty percent of peripheral blood chrotoscnes were aneuploid after PHA stimulation compared to less than 5 percent usually found. This increased to 48 per cent in skin fibroblasts after 6 months in tissue culture. Chromosome studies of the patient's two children, mother, father and two brothers were normal. G, D, and C group chromosomes were aneuploid, but not A, B or F. 13 of 25 clones from single cells grew up, and greater than 30 per cent aneuploidy was demonstrated in each one. These findings may be secondary to in vitro tissue culture conditions, and may not represent a defect in cell division in vivo. Mouse cells, for example, demonstrate high aneuploid rates in vitro. Nevertheless, these findings also may represent a new genetic mutation of mitotic cell division, perhaps in spindle fiber formation, and may be related to clinical aneuploid conditions such as trisomy chromosome syndromes.