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PS 10-24 EFFECT OF PREHYPERTENSION ON LEFT VENTRICULAR FUNCTION

Objective: Awareness of prevalence, determinants, and prognosis of asymptomatic untreated prehypertension is still lacking especially in India and subcontinent. The aim of present study is to compare left ventricular function between prehypertensives and normotensives. Design and Method: Total 200 subjects were selected from general population with the age range between 18 to 70 years. Blood pressure was measured with mercury sphygmomanometer and prehypertension was classified according to JNC 7. 100 subjects were prehypertensives and 100 were normotensives. Two-dimensionally guided M-mode echocardiography was performed by standard methods. Results: It was observed that the BMI and BSA were elevated in prehypertensives. SBP, DBP, HR, PP & MAP were significantly elevated (p < 0.001) in prehypertensives compared to normotensives. It was observed that the stroke volume, cardiac output, cardiac index, body mass index, body surface area was elevated in prehypertensives. Systolic blood pressure, diastolic blood pressure, heart rate, pulse pressure,mean arterial pressure, end systolic stress, and end isovolumetric systolic stress were significantly elevated (p < 0.001) in prehypertensives compared to normotensives. Visual assessment of E/A ratio was less in prehypertensive. Ejection fraction and fractional fiber shortening were noted to be within normal range. Conclusions: Such findings carry prognostic implication. Early diagnosis of prehypertension will help to take necessary preventive measures to reduce cardiac mortality and morbidity.The care of prehypertensive subjects should include, reducing the afterload in order to improve the left ventricular contractile state as early as possible. These early changes are reversible by various non pharmacological and pharmacological measures. So it is advisable to do routine echocardiography after the age of 40 years.