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Biological efficiency of ultra- and hypofractionated irradiation of a proton scanning beam

The results of the protons biological effectiveness on tumor cells under hypofractionated irradiation with the division of a single (daily) dose into two, three, and four equal fractions (ultrafractionation) are presented. The proposed schemes for splitting the daily dose into fractions were selected in order to reduce the dose to healthy tissues and critical organs located at the proton beam pathway.