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Association of a Family History of Coronary Heart Disease With Initiation of Statin Therapy in Individuals at Intermediate Risk: Post Hoc Analysis of a Randomized Clinical Trial.

Association of a Family History of Coronary Heart Disease With Initiation of Statin Therapy in Individuals at Intermediate Risk: Post Hoc Analysis of a Randomized Clinical Trial A family history of coronary heart disease (CHD) is associated with an approximately 1.5to 2.0-fold higher risk of CHD independent of conventional risk factors,1 highlighting the contribution of genetic factors to disease susceptibility. Whether discussion of risk associated with a family history of CHD influences shared decision making regarding statin initiation is unknown. The Myocardial Infarction-GENES (MI-GENES) study2-4 tested the hypothesis that incorporating a multilocus genetic risk score (GRS) into CHD risk estimates would be associated with lower low-density lipoprotein cholesterol levels. We conducted a post hoc analysis to assess whether disclosure of risk associated with a family history of CHD was associated with initiation of statin therapy.