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Antiviral Activity in Sera of Patients with Crohn's Disease

Sera from patients with Crohn's disease were tested for antiviral activity using a microtiter assay with end points showing 50% reduction of cytopathic effects. Patients were significantly more likely to have serum antiviral activity equivalent to interferon levels of 20 or more units/ml than were control subjects. The mean antiviral activity in the patients' sera (34 ± 20 (s.d.) units/ml) was significantly greater than that in the control subjects' sera (0.6 ± 1.7 (s.d.) units/ml). Following acidification the mean antiviral activity of the patients' sera (28 ± 17 (s.d.) units/ml) had not changed significantly while heat inactivation resulted in significant loss of activity (7.5 ± 2.7 (s.d.) units/ml). These findings are suggestive of the presence of circulating leucocyte interferon in the sera of patients with Crohn's disease. [Am J Med Sci 1983; 286(1):21–25.]