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Association between C‐reactive protein gene +1059 G/C polymorphism and the risk of coronary heart disease: a meta‐analysis

Background C‐reactive protein (CRP) gene +1059 G/C polymorphism has been reported to be associated with coronary heart disease (CHD) risk, but the results remain inconclusive. This meta‐analysis was therefore conducted to clarify these controversies. Methods A comprehensive search was conducted to identify all case control studies on the association between CRP gene +1059 G/C polymorphism and CHD risk. All the related studies were further strictly selected according to the inclusion criteria. Meta‐analysis was performed with STATA 10.1 (StataCorp, USA). The association was assessed by odds ratio (OR) and 95% confidence interval (CI); both Begg's funnel plot and Egger's regression test were used to assess the publication bias. Results This meta‐analysis on a total of 13 studies comprising 6316 CHD cases and 4467 controls showed no significant association between CRP gene +1059 G/C polymorphism and CHD risk in the overall study (for C/C+C/G vs. G/G: OR=1.01, 95% CI=0.81‐1.25, P=0.96; for C/C vs. C/G+G/G: OR=1.17, 95% CI=0.77‐1.77, P=0.47; for C/C vs. G/G: OR=1.17, 95% CI=0.77‐1.77, P=0.47; for C allele vs. G allele: OR=1.01, 95% CI=0.81‐1.24, P=0.96). However, in the subgroup analysis by ethnicity, the results showed significant association between CRP gene +1059 G/C polymorphism and CHD risk among Caucasians (for C/C vs. G/G: OR=2.54, 95% CI=1.13‐5.72, P=0.02; C/C vs. C/G+G/G: OR=2.45, 95% CI=1.09‐5.51, P=0.03), but not among Asians and Africans (P >0.05). Conclusion CRP gene +1059 G/C polymorphism may be associated with increased CHD risk among Caucasians and more evidences need to validate the conclusion.