{'fraction_non_alphanumeric': 0.05978784956605593, 'fraction_numerical': 0.04628736740597879, 'mean_word_length': 5.290909090909091, 'pattern_counts': {'":': 0, '<': 6, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Prognostic factors of colorectal cancer: K‐ras mutation, overexpression of the p53 protein, and cell proliferative activity

Between June 1990 and April 1991,62 colorectal tumors were assessed in a prospective fashion on the basis of various tumor characteristics. Parameters included K‐ras mutation, overexpression of the p53 protein, and proliferating cell nuclear cell antigen, as well as standard histopathologic examination. A multivariate analysis showed that K‐ras mutation correlated with vascular invasion (P < 0.01) and hematogenous metastasis (P < 0.01). With regard to survival time, multivariate analyses using the Cox proportional hazard model suggested that status of lymph node metastasis (P<0.01, relative risk [rr]=7.27), TNM stage (P < 0.05, rr=5.37), lymphatic invasion (P < 0.05, rr=4.48), and K‐ras mutation (P < 0.06, rr=3.69) are the most independent prognostic factors. We compared the prognostic value of the molecular assays and standard TNM prognostic factors by multivariate analysts. © 1994 Wiley‐Liss, inc.