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CORRECTIONOFPROTEIN OXIDATIVE MODIFICATION WITH QUERTINE IN PATIENTS WITH URONEPHROLITHIASIS COMORBID WITH METABOLIC SYNDROME

Key words: quertine, urate nephrolithiasis, metabolic syndrome, protein oxidative modification. The aim of the research was to study the effect of quertine on the processes of protein oxidative modification in patients with urate nephrolithiasis comorbid with metabolic syndrome. 118 patients, divided into three groups, were examined and treated. Group 1 (control) included patients with urate nephrolithiasis, who were prescribed traditional therapy. Group 2 (experimental) embraced patients with urate nephrolithiasis comorbid with metabolic syndrome, who were prescribed traditional therapy and generally recognized drugs that correct metabolic disorders. Group 3 (main) involved patients with urate nephrolithiasis comorbid with metabolic syndrome, who received traditional therapy and drugs that correct metabolic disorders. To study the state of protein peroxidation, the indicators of protein oxidative modifications were analysedwith the method designed by E.E. Dubininaet al. The study of indicators in the blood serum was performed before treatment and after 7 days, after 14 days, after 1.5-2 months, after 3-6 months. In patients with urate nephrolithiasis, prooxidant activation was observed in the course of traditional therapy: the level of neutral aldehyde and ketone derivatives as well as of alkaline aldehyde derivatives increased. Patients with urate nephrolithiasis and urate nephrolithiasis comorbid with metabolic syndrome demonstrated the development of oxidative stress, manifested by the accumulation of the content of products of protein oxidative modification. After the treatment with quertine, which contains the aglycone of various plant flavonoid glycosides, a more significant decrease in the indicators of protein oxidative modification was noted comparing to experimental group patients; this indicates the antioxidant properties of quertine. Thus, the use of quertine together with traditional therapy and drugs that affect metabolic disorders, differentiated between uricostatic and uricolytic agents, contributed to the normalization of the content of protein peroxidation products.