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Abstract P168: Drug-Drug Interactions in Hospitalized Cardiac Patients and It's Clinical Management

Drug Interaction refers to modification of response to one drug by another when they are administered simultaneously or in quick succession, receiving multi drug therapy is a major concern. Polypharmacy is the administration of many drugs at the same time and several drug interactions are desirable and deliberately employed in therapeutics and the severity of drug interactions in most cases is highly unpredictable.
 
 Aim and objectives:
 The present study was to identify major DDI’s in patients with cardiovascular disease and assess the various organ systems affected by the DDI’s.
 
 
 Discussion and Conclusion:
 During the study period a total of 80 prescriptions were analysed and it was found that 35 patients had multiple major DDIs. The percentage of DDIs was higher in males 27.77% (25 of 90) than females 11.11% (10 of 90). Clopidogrel: aspirin 27.77% (25 of 90) was the most predominant DDI, followed by Aspirin : Furosemide 22.22% (20 of 90), Heparin : Aspirin 18.88% (17 of 90), Clopidogrel : Heparin 17.77% (16 of 90), Carvediloló Digoxin 3.33% (3 of 90), Ondansetron : Metronidazole 2.22% (2 of 90), Telmisartan : Digoxin 2.22% (2 of 90), Aspirin : Spironolactone 2.22% (2 of 90), Atorvastatin : Diltiazem 1.11% (1 of 90), Heparin : Nitroglycerin 1.11% (1 of 90), Aspirin : Torsemide 1.11% (1 of 90). Bleeding 65.83% (59 of 90) was the commonest clinical consequence followed by Urinary system disorder 25.55% (23 of 90), Heart rate and Rhythm disorders 7.77% (7 of 90), and musuloskeletal disorder 1.11% (1 of 90). There was an ADR identified during the study which was Aspirin : Furosemide induced Grade I renal parenchymal disease. On assessment of DDI’s majority of the cases were classified as major in severity. Atmost care must be taken to optimise the therapy, thereby we can improve the outcome.
 
 
 Keywords:
 Drug Interactions, Nitroglycerin, Heart Rate.
