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EFFECTS OF NOREPINEPHRINE, ANGIOTENSIN, DIHYDROERGOTAMINE, PAPAVERINE, ISOPROTERENOL, HISTAMINE, NICOTINIC ACID, AND XANTHINOL NICOTINATE ON RETINAL OXYGEN TENSION IN CATS

The oxygen tension in the vitreous body close to the retina, PvrO2, was determined continuously in cats. The effects on PvrO2 of intraarterial injections of various vasoactive drugs were determined. The vasoconstrictors norepinephrine, angiotensin and dihydroergotamine did not change PvrO2 in five cats. The same result was obtained with the vasodilators isoproterenol, histamine and xanthinol nicotinate in five cats, and with nicotinic acid in six cats, while papaverine invariably increased PvrO2 in seven cats when injected intraarterially and in two cats when injected intravenously. It is suggested that the ability to penetrate the blood‐retinal barrier may play an important role in determining the effect of vaso‐active drugs on retinal blood flow.