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Allergen-Specific Cytokine Production by Human Nasal Polyps

Objective: Study the ex vivo allergen-specific cytokine responses of cells derived from human nasal polyps. We hypothesized that nasal-polyp derived human respiratory cells from atopic individuals would respond with reduced IL10 compared with cells from nonatopics. Method: Thirty-one nonsmoking adults with nasal polyposis requiring surgery were recruited. Atopic status was determined by skin prick tests. Polyps were harvested during routine surgery. After digestion with collagenase, cell suspensions were incubated with positive and negative allergen (cat, grass, or HDM) for 6 days. Cytokine detection was by cytometric bead array. Results: IL-10 was induced in nasal polyp cell suspensions derived from both atopics and nonatopics with the addition of allergen in a dose-response fashion. Conclusion: Our results indicate that IL-10 producing T cells regulate Th2 cytokine production in nasal-polyp derived human airway cells.