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CHEMOREFLEX OPPOSES THE INCREASE IN THE ARTERIAL BLOOD PRESSURE (ABP) PRODUCED BY LOW PROTEIN DIET (LPD) IN RATS

LPD has been shown to augment the ABP and the responsiveness of the baroreflex and Bezold‐Jarisch reflex in conscious rats (Tropia et al., 2001). In this work we sought to define the role of the chemoreflex in determining the ABP of LPD rats. After wean, male Fisher rats were divided in 4 groups: control, 15% diet protein along 35 days (n=18) and denervated control (n=08); LPD, 6% diet protein along 35 days (n=18) and LPD denervated (n=08). One day before the experiments, polyethylene cannulas were inserted into the femoral artery to record ABP and vein to inject drugs. Chemoreflex was elicited by i.v. KCN at 5, 10, 15, 20 and 40 μg/kg doses. After that, rats were submitted to selective chemoreceptor denervation (SCD) and 24 hours later new recordings of ABP and HR were taken. LPD increased ABP (139±3 vs. 115±2mmHg) and HR (442±13 vs. 401±8bpm). Pressor responses by KCN increased 52±28% whereas bradycardic responses increased 212±74% on average in LPD rats. Astonishing, SCD increased the ABP (Δ22±5mmHg) and HR (Δ83±32bpm) in LPD rats. The results showed that LPD increases the chemoreflex responsiveness with a strong parasympathetic discharge in response to chemoreflex activation. Also, chemoreflex abnormalities could oppose a further increase of the ABP in LPD rats since SCD produced an increment of the baseline ABP.