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Chlorogenic acid supplementation improves skeletal muscle mitochondrial function in a rat model of resistance training

Chlorogenic acid (CA), is a polyphenol abundantly found in several foods. Different pharmacological roles of CA, including its effect on body weight, become a subject of research interest. In the current study, the effect of CA supplementation was evaluated on the muscle mitochondria function in an animal model of resistance training (RT). Rats were allotted into control, CA (100 mg/kg) without RT, RT, RT + CA 10 mg/kg, RT + CA 50 mg/kg, and RT + CA 100 mg/kg. It was found that CA supplementation (10, 50, and 100 mg/kg, gavage, 56 consecutive days) significantly improved muscle strength and mitochondrial function, especially when it was co-administered with the RT program. The present findings suggest that CA supplementation with RT improved muscle function by regulating mitochondrial function and cellular energy metabolism. Therefore, CA could be a promising, supplementary/therapeutic agent against a variety of skeletal muscle-associated complications.