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The reciprocal dance between cancer and development.

Cellular proliferation is indispensable for the development of every multicellular organism and tissue; ironically, however, the genetic program that controls proliferation is frequently subverted during the process of carcinogenesis. Indeed, the very reliance of multicellular organisms on proliferation for normal development renders them susceptible to cancer. The effects of ovarian hormones on the breast aptly illustrate the relation between development and carcinogenesis. Estrogens and progesterone, which are essential for the development of the mammary gland, regulate the proliferation and differentiation of mammary epithelium during puberty and pregnancy. Yet, ovarian hormones also have a preeminent role in the development of breast . . .