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TYPE II CELLS ISOLATED FROM NEWBORN RATS EXPOSED TO 100% OXYGEN HAVE DECREASED SECRETION OF SURFACTANT PHOSPHOLIPIDS

Type II cells isolated from 6 day old rats and cultured for 24 hours in 95% air, 5% CO2 actively secreted phospholipids into the medium. The ratio of disaturated phosphatylcholine (DSPC) to the phosphatylcholine in the media of cells obtained from room air controls was 81%. A similar ratio of DSPC to PC was found in the cells themselves. PC accounted for 59% of total phospholipid in both the cells and in the medium. PG concentration was approximately 10% in the cells and 11% in the medium. The ratio of phospholipids in cells cultured in O2 for 24 hours was reduced by 30%. The ratio of PC to total extracted phospholipid secreted into the medium by oxygen exposed cells was also decreased by 30%. Type II cells were also isolated from newborn rats exposed to 100% oxygen for 6 days. Yields of cells from oxygen treated animals was about 75% of room air controls (approximately 6.6 × 106 cells per rat versus 8.6 × 106 cells per rat). These studies indicate that functional type II cells can be isolated from oxygen exposed newborn rats and that surfactant synthesis is decreased by 24 hours of oxygen exposure. Supported by USPHS Grant HD 17785.