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Recruitment for an Advance Care Planning Study: Lessons Learned

bition of quorum sensing rather than antimicrobial properties seem to be responsible for the beneficial effects of macrolides in individuals with DPB. In addition to these immunomodulatory effects, an increasing effect of the airway mucociliary transport system seems to be responsible for effects in individuals with DAB. A previous study focused on the airway clearance system for the prevention of aspiration pneumonia found that the frequency of hospitalization due to pneumonia after treatment with macrolides was significantly less than before the intervention. The current findings suggest that the risk of exacerbation was approximately 30% lower if clarithromycin was used in individuals with DAB. Macrolide therapy may therefore be beneficial in reducing the risk of exacerbation in these individuals.