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Evidence that sensitization to triple‐knockout pig cells will not be detrimental to subsequent allotransplantation

The current evidence is that sensitization to a pig xenograft does not result in the development of antibodies that cross‐react with alloantigens, and therefore, sensitization to a pig xenograft would not be detrimental to the outcome of a subsequent allograft. This evidence relates almost entirely to the transplantation of cells or organs from wild‐type or α1,3‐galactosyltransferase gene‐knockout (GTKO) pigs. However, it is not known whether recipients of triple‐knockout (TKO) pig grafts who become sensitized to TKO pig antigens develop antibodies that cross‐react with alloantigens and thus be detrimental to a subsequent organ allotransplant.