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Serum Levels of Cardiotroponin I in Burn Patients and Its Relation to Outcome of the Disease.

One of the most specific markers of myocardial damage is cardiotroponin I (CTNI). Serum CTNI levels increase 2 to 3 hours after myocardial injury.1 It is an important marker for determining treatment plans for patients.2 We undertook a descriptive analytic study with the support of Tabriz University of Medical Sciences to investigate CTNI levels in burn patients (No. 93/1–7/26, approved by Regional Ethics Committee of Tabriz University of Medical Sciences [No. 5/4/2441]). Sixty patients admitted to the burn ward were enrolled in the study after providing consent. Serum CTNI levels were measured on the first day and 72 hours later. The average age of patients was 22.4 ± 30.3 years. There was a significant relationship between the variable of burn percentage and CTNI levels on the first day (P < .007) and 72 hours later (P < .001). Also, a significant association was present between outcome of the illness and enzyme levels on the first day (P = .002) and 72 hours later (P = .044). The CTNI levels were elevated in 25% of patients at the first assessment and 13.3% at the second assessment. Elevated enzyme levels have previously been investigated as a mortality risk factor,3 though no significant association was found. In patients with TBSA burns exceeding 30%, CTNI levels were found to be increased.4 In the present study, there was a significant correlation between the percentage of burn and the increase in serum CTNI. This finding bears consideration during decision making in the intensive care unit. It is worth noting that the enzyme was quantified by enzyme-linked immune sorbent assay (ELISA) using calibrated pipettes. Although the qualitative method (Bedside Slide Test) for analysis of CTNI has been confirmed,5 it has 18% sensitivity.6 REFERENCES