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ANTI PROLIFERATIVE EFFECTS OF LASIENTHERA AFRICANUM ON PROSTATE EPITHELIAL CANCER CELLS

The plants that possess therapeutic properties and exerting beneficial pharmacological effects on the animal body are generally designated as medicinal plants. The world health organization (WHO) estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. Plant preparations have less adverse reactions when compared to modern conventional pharmaceuticals. Infectious diseases account for high proportion of health problems and several microorganisms have developed resistance to many synthetic drugs and antibiotics. This has created immense clinical problems in the treatment of infectious diseases. This situation forced scientists to search for various sources, such as medicinal plants. One of the plants that can be used as herbal medicine is Lasienthera africanum. This plant is used in herbal medicine for the treatment of skin itches, as an antiseptic for wounds, and externally for leprosy and scabies. Lasienthera africanum is a low erect or subscandent, vigorous shrub with stout recurved prickles and a strong odour of black currents; L.africanum has several uses, mainly as an herbal medicine and Plant extracts are used in folk medicine for the treatment of cancers, chicken pox, measles, asthma, ulcers, swellings, eczema, tumours, high blood pressure, bilious fevers, catarrhal infections, tetanus, rheumatism and malaria of abdominal viscera. The aim of the dissertation is to extract the active compounds from leaf and flower of the L.africanum by using various solvent and and anticancer activity on PC3 epithelial cancer cell lines. An attempt has been made to study the anticancer activity, by using the extracted crude and column cleaned up compounds from naturally occurring L.africanum plant. The results showed crude compound is more effective on prostate epithelial cells . Based on the above results it is suggested that the L.africanum plant can be used for Cancer therauptics.