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Hypermethylation of tumour suppressor genes in ocular adnexal lymphoma

Purpose Promoter hypermethylation occurs in various tumours, including ocular adnexal lymphomas (OAL), and is a mechanism by which tumour suppressor genes can be inactivated during tumourigenesis. This study aimed to investigate the levels of hypermethylation and specific genes that are hypermethylated in different subtypes of OAL using methylation‐specific multiplex ligation‐dependent probe amplification (MS‐MLPA) and pryrosequencing.