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A Comparative Study of Robust Feature Detectors for 2D Electrophoresis Gel Image Registration

In this study we consider the performance of different feature detectors used as the basis for the registration of images from two-dimensional gel electrophoresis. These are three spot detectors also used to identify proteins, and two domain independent keypoint detectors. We conduct a case study with images from a publically available data set which are synthetically distorted using thin plate splines. The performance is assessed by the repeatability score, the probability of an image structure to be detected in original and distorted images with reasonable localization accuracy.