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Association study of 15 novel single‐nucleotide polymorphisms of the T‐bet locus among Finnish asthma families

Objective T‐box expressed in T cells (T‐bet) is a transcription factor regulating the commitment of T helper (Th) cells by driving the cells into the Th1 direction. Abnormal Th1/Th2 balance may lead to complex disorders like asthma or autoimmune diseases. Recent studies have suggested that T‐bet might be a candidate gene for asthma. This led us to screen 23 Finnish individuals for single‐nucleotide polymorphisms (SNPs) in the T‐bet locus and study the association between the SNPs and high serum IgE level and asthma.