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Contribution of acetylcholine, vasoactive intestinal polypeptide and nitric oxide to CNS‐evoked vagal gastric relaxation in the rat

Abstract Several in vitro models of gastric relaxation have elucidated a role of nitric oxide (NO) and vasoactive intestinal polypeptide (VIP) in non‐adrenergic, non‐cholinergic (NANC) vagally mediated gastric relaxation. However, these models do not necessarily mimic the events leading to gastric relaxation in the whole animal. We have recently described a vagally mediated gastric relaxation evoked by micro‐injection of substance P (SP) into the nucleus raphe obscurus (NRO). The present study was performed to elucidate whether this CNS‐stimulated in vivo gastric relaxation involved acetylcholine, NO and VIP.