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Revised UNAIDS/WHO Ethical Guidance for HIV Prevention Trials.

The Joint United Nations Programme on HIV/AIDS (UNAIDS) and the World Health Organization (WHO) recently released a new version of their guidance document Ethical Considerations in HIV Prevention Trials.1 A 12-month collaborative process formed the basis of the revised guidance points. Representatives of communities with an increased risk of acquiring HIV infection, regulatory authorities, manufacturers, prevention researchers, trial designers, trial sponsors, relevant funders, biostatisticians, and ethicists participated in the revision process.1 The participants reviewed the existing guidance points from previous versions and drafted new ones that were further developed in an iterative process between the participants, their wider networks, and a writing group1 for this guidance document in 2020, published by UNAIDS and WHO in January 2021. The resulting revised guidance addresses from the perspective of UNAIDS/WHO essential ethical elements for the development of safe and effective HIV prevention interventions.