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Methodology for the assessment of burden of smear-positive pulmonary TB and its infectivity.

OBJECTIVE
The study investigated the burden of smear-positive pulmonary TB and its infectivity using DALY (disability-adjusted life year) as an indicator.


METHODS
An assumed cohort of 2,000 cases was set up based on the age-specific incidence of 794 newly registered smear-positive cases in Beijing in 1994. Prognostic trees and model diagrams of infectivity under natural history and DOTS(directly observed treatment, short-course) strategy were established according to the epidemiological evidence.


RESULTS
The results showed that 29.6% of DALYs would be neglected if the burden caused by the infectivity was not considered.


CONCLUSION
DOTS strategy may reduce 97.3% of the number of potential cases infected, 92.9% of DALYs related to TB-patients themselves, and 99.9% of DALYs caused by TB's infectivity as well.