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Inactivation of Ascaris suum by Short-Chain Fatty Acids

ABSTRACT Ascaris suum eggs were inactivated in distilled water and digested sludge by butanoic, pentanoic, and hexanoic acids. The fatty acids (short-chain fatty acids [SCFA]) were effective only when protonated and at sufficient concentrations. The conjugate bases were not effective at the concentrations evaluated. Predictions from an inhibition model (50% inhibitory concentration [IC50]) based on quantitative structure-activity relationships were congruent with inactivation data.