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Constructing reduction-sensitive PEGylated NIRF mesoporous silica nanoparticles via a one-pot Passerini reaction for photothermal/chemo-therapy.

In this work, we decorated the surface of MSNs by a one-pot Passerini reaction using near-infrared fluorescence BODIPY and poly(ethylene glycol) with an aldehyde group (PEG-CHO) for the first time. Doxorubicin (Dox) was loaded to demonstrate the reduction response. The formed MSNs neatly integrate chemotherapy, photothermal therapy and near-infrared fluorescence (NIRF) imaging.