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Identification of alpha‐actinin 4 and 67 kDa laminin receptor as stage‐specific markers in esophageal cancer via proteomic approaches

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies in the world with a very poor prognosis. The majority of ESCC patients present with advanced metastatic disease upon diagnosis. Therefore, it is important to understand the molecular mechanism in the tumor invasion process and to find new biomarkers for early diagnosis and prognostic evaluation.