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Quasi-steady state assumptions in the modelling of bioreactors: model reduction and validation

The quasi-steady state assumption is a usual and convenient way to obtain reduced order models. However its applicability is in general strongly dependent on field expertise and ad hoc considerations. The paper is an attempt to introduce a systematic procedure for identifying possible quasi-steady state assumptions and to check their consistency for the case of dynamical models of bioreactors. The result is a combination of symbolic and numerical manipulations. The procedure is tested on the model of a bioreactor with one substrate species, one biomass species, and aeration.