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Mitochondrial DNA Abundance is Maintained by APE1 in Liver of Mice Treated with AOM

The liver is the body's largest internal organ which performs many metabolic processes, including detoxification of several classes of carcinogens. Because of the numerous critical functions performed by the liver, degenerative liver diseases such as hepatitis, cirrhosis, and liver cancer are especially life‐threatening. Previous research indicates, that in liver cancer, mitochondrial function is altered. Base Excision Repair (BER) is the primary mechanism for the repair of alkylation and oxidative DNA damage in mitochondria. Our research is focusing on the study of the protein apurinic/apyrimidinic endonuclease 1 (APE 1). The alkylating agent azoxymethane (AOM) is a carcinogen widely used for the induction of colorectal cancer in rodents. AOM is bioactivated in the liver, thus this organ could represent a primary target of AOM action and a model for liver carcinogenesis.