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Comparison of the immunocytochemical localization of DARPP‐32 and I‐1 in the amygdala and hippocampus of the rhesus monkey

Dopamine and adenosine 3′:5′‐monophosphate (cAMP) regulated phosphoprotein of Mr 32 kDa (DARPP‐32) and phosphatase inhibitor 1 (I‐1) have been associated with intracellular signal transduction processes and share several biochemical features. Localization of each phosphoprotein in distinct neural structures will aid investigation of their physiologic properties and help identify their unique roles in the nervous system. We have compared the distribution of the two phosphoproteins in the amygdala and hippocampus of the rhesus monkey with the aid of immunocytochemical procedures. Neurons immunoreactive to antibodies raised against the phosphoproteins DARPP‐32 and I‐1 were noted in the cortical, central, and components of the basal group, including the basomedial, the lateral, and to a lesser extent, the basolateral amygdaloid nuclei. Within the large basal nuclei positive neurons were found preferentially in their medial and ventral subdivisions. By making a direct comparison in the same animals, we observed differences in the distribution of the two phosphoproteins in the amygdala. DARPP‐32 and I‐1 positive neurons overlapped partially in the basal nuclei, to a lesser extent in the cortical, but were segregated in the central amygdaloid nucleus with neurons positive for DARPP‐32 noted laterally, and for I‐1 medially.