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[A study on immunological skin reactions in patients with active pulmonary tuberculosis. Clinical significance of the reduction of DNCB reaction in patients with active pulmonary tuberculosis].

In the previous paper, it was reported that DNCB reaction as immunological skin test showed marked reduction in active pulmonary tuberculosis. In the present study, it was tried to clarify the clinical significance of the reduction of DNCB reaction, and the results were summarized as follows: 1) Seventy-four percent of patients showed reduced reaction to DNCB. Among them, 77% showed normal reaction to PPD and 23% were negative. 2) Those with reduced DNCB reaction showed a tendency of increased immunoglobullins (IgG and IgM). 3) There was significant correlation (p<0.05) between the extent of lesions on chest roent genogram and the rate of negative reaction to DNCB. The more the extent of lesion the higher the negative reaction to DNCB. 4) When clinical improvement was achieved with antituberculous drug therapy, DNCB reaction was enhanced in 26 (79%) out of 33 cases with reduced DNCB reaction before treatment. These results suggest that reduced DNCB reaction indicates the hypofunction of cellular immunity in pulmonary tuberculosis, and DNCB test could be used as an important indicator to estimate the clinical prognosis.