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Development of Bacteriophage Therapy for the Skin Disease Acne

We are investigating the potential for bacteriophage therapy to treat the skin disease acne. Acne has varying symptoms and a multifactorial etiology, but the more serious lesions of acne vulgaris result from infection by the bacterium Propionibacterium acnes. Current acne treatments include broad spectrum antibiotics. Replacing or supplementing such compounds with an antibacterial agent targeted specifically against the pathogen can reduce or eliminate some deleterious effects of chemical antibiotics. However, the highly limited host range of most bacteriophage suggests that no single bacteriophage type will be capable of growing on all members of the bacterial species of interest. We have therefore collected from human skin a large number (several dozen) of bacteriophage isolates capable of lytic growth on P. acnes, along with a much larger collection (ca. 400) of P. acnes bacterial isolates for investigation of bacteriophage host range. Preliminary plating results indicate that the majority (greater than 95%) of Introduction