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Estimation of axon counts in a rat model of glaucoma: comparison of fixed‐pattern sampling with targeted sampling

Background:  Full axon counting of optic nerve cross‐sections represents the most accurate method to quantify axonal damage, but such analysis is very labour intensive. Recently, a new method has been developed, termed targeted sampling, which combines the salient features of a grading scheme with axon counting. Preliminary findings revealed the method compared favourably with random sampling. The aim of the current study was to advance our understanding of the effect of sampling patterns on axon counts by comparing estimated axon counts from targeted sampling with those obtained from fixed‐pattern sampling in a large collection of optic nerves with different severities of axonal injury.