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Identification of Sodium‐Dependent, High‐Affinity Choline Uptake Sites in Rat Brain with [3H]Hemicholinium‐3

Abstract: [3H]Hemicholinium‐3 (HC‐3) was used to label sodium‐dependent, high‐affinity choline uptake sites in regions of rat brain. Autoradiography revealed a high density of [3H]HC‐3 binding sites in brain regions with a high density of cholinergic terminals, such as the interpeduncular nucleus, caudate‐putamen, and olfactory tubercle. This distribution of [3H]HC‐3 binding sites was in close agreement with the amounts of choline acetyltrans‐ferase in specific nuclei and subregions of rat brain. Destruction of presynaptic cholinergic projections in the cerebral cortex and the basal ganglia by injection of excitotoxins reduced [3H]HC‐3 binding by 40–50%. These data indicate that sodium‐dependent [3H]HC‐3 binding sites are related to the choline transport system present in cholinergic neurons.