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Pioglitazone Or Exercise Effects On LV Diastolic Function In Adults With MCI And Insulin Resistance: 755 Board #71 June 1, 3: 30 PM - 5: 00 PM.

PURPOSE: This study followed our award winning clinical abstract from ACSM 2015. Human diving reflex is well known reaction of the cold water immersion. However only limited data are available for those cases, when clinically significant case appears. The aim of the study was to monitor hemodynamic response for two groups of individuals one with physiologically appropriate reaction, and second with pathological reaction manifested by clinically relevant symptoms. METHODS: Two groups of individuals were monitored during cold water face immersion. Each individual placed the face into the cold water ( 7oC) immersion until exhaustion. The test has been repeated three times for each individual. The cardiovascular hemodynamic parameters were monitored via 12 lead ECG and noninvasive bioimpedance system PhysioFlow. The following parameters were recorded: heart rate (HR), stroke volume (SV), cardiac output (CO), and systemic vascular resistance (SVR). RESULTS: 2 individuals with symptomatic pathology (presyncope, dizziness or dyscoordination during swimming) and 5 normal individuals were included. All together 21 measurements were recorded. The detailed information are included in the following table: CONCLUSION: Our study demonstrated for the first time, that pathological (overshoot) response to the face water immersion is not only manifested by severe bradycardia. This is rather a whole body circulatory collapse with clinically relevant drop in heart rate and stroke volume resulting in insufficient cardiac output, compensated by global systemic vasoconstriction. Results might help us to understand better possible causes of the sudden death of swimmers and triathlon racers..