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Effect of Pretreatment with Ketotifen on Pollinosis: Correlation with Eosinophil Cationic Protein

In this study, we examined the effect of pretreatment with ketotifen on pollinosis, and correlations with the concentration of ECP in nasal discharge and the existence of eosinophils in nasal smear. Ketotifen was prophylactically administered to 74 patients with pollen allergy, and the treatment continued to the end of pollen season. An additional 25 patients with the same allergy commenced ketotifen treatment during the pollen season. The results showed that pretreatment with ketotifen reduced symptom scores during the pollen season, but did not suppress the increase in ECP concentration and eosinophil influx into the nasal sample. We suggest that pretreatment with ketotifen is useful for the treatment of pollinosis, and its effects may not be the result of suppression of eosinophil activation.