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Functional polymorphism of matrix metalloproteinase‐9 (MMP‐9) gene and response to lithium prophylaxis in bipolar patients

Matrix metalloproteinase 9 (MMP‐9) has been implicated in a number of pathological conditions including cancer and heart diseases, and recently also in such neuropsychiatric disorders as schizophrenia and bipolar illness. Therefore, we investigated a possible association between functional polymorphisms of the MMP‐9 gene and the response to lithium, the main mood‐stabilizing drug in bipolar illness.