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Accelerometer-measured light-intensity physical activity and risk of cardiovascular disease or death in older adults: A meta-analysis.

BACKGROUND
Light-intensity physical activity (LPA) is related to reduced risk of all-cause death in older adults, but its effect on cardiovascular disease or death remains questioned. This meta-analysis was aimed to quantify the association of LPA with risk of cardiovascular disease and death in older adults.


METHODS
We conducted a literature search in electronic databases for prospective cohort studies assessing the relationship between LPA measured by accelerometers and risk of cardiovascular disease and/or death in adults aged ≥60 years. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled using a random-effects model.


RESULTS
Of the 518 citations identified, 5 prospective cohort studies were included. The mean body mass index of included participants was all over 25 kg/m2. Pooled results showed that the summary HR per 60 min/day higher of LPA was 0.90 (95% CI, 0.83-0.98; n = 3) for risk of cardiovascular disease and 0.59 (95% CI, 0.49-0.72; n = 2) for cardiovascular death. Both the relationship of LPA with risk of cardiovascular disease and that with risk of cardiovascular death were linearly- and inversely-shaped. The HR for risk of cardiovascular disease was bigger for LPA than moderate-to-vigorous physical activity (MVPA), in either equal time or equal amount scale (both Pinteraction < 0.01); but the HR for risk of cardiovascular death was comparable between LPA and MVPA in both scales (both P interaction ≥0.20).


CONCLUSIONS
Higher LPA is associated with reduced risk of cardiovascular disease and death in older adults.