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Fine Structural Features of Coronary Vasculogenesis in Collagen Lattices

The morphogenetic events leading to the formation of coronary circulation have been previously described,' but the developmental mechanisms involved are still poorly understood. We have proposed that coronary vasculogenesis results from interactions between primary precursor tissues that include the myocardium, dorsal mesocardium, and the epicardium? In order to analyze the mechanisms involved in these putative tissue interactions, a tissue culture model was established (cf Bolender et al., this volume). We report here further characterization of the culture model at the ultrastructural level.