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The Effects of Q-Switched Nd:YAG Laser Irradiation in the Wavelength of 1064nm and 532nm on Guinea Pigs' Skin Tissue

To investigate the effect of Q-switched Nd:YAG laser irradiation in the wavelength of 1064 nm and 532 nm on guinea pigs' skin tissue, according to the method and dose which are used clinically to treat pigmentary skin diseases, so as to provide some reference and foundation for the clinical usage of Q-switched Nd:YAG laser. Three different doses of Q-switched Nd:YAG laser in the wavelength of 1064 nm and 532 nm were used respectively for in vitro irradiation on guinea pigs, then the histological change of the skin tissue were observed and analyzed with microscope and image analysis instrument. Each experimental group showed obvious histological changes, and with the increase in doses, the extent of change became larger. The single-pulse energy density of Q-switched Nd:YAG laser plays a main role in the change of the skin tissue; with the same irradiation dose there is no difference in the effects of the two wavelengths (1064 nm and 532 nm) on skin tissue; the green light with the wavelength of 532 nm can be absorbed by epidermal melanin granules and shatter the melanin granules much more effectively than the infrared light with the wavelength of 1064 nm; and in the same wavelength, the larger the dose, the better the shattering effect on melanin