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RAD51 / YER095W Phenotype


Non-essential gene; null mutant is sensitive to DNA damaging agents, DNA synthesis and topoisomerase inhibitors; null mutant is sensitive to X-rays, gamma rays and UV radiation; null displays increased chromosome instability, increased loss-of-heterozygosity in diploids, an increased mutation rate and elevated Ty element transposition; null mutant is temperature sensitive, and has both a decreased growth rate and competitive fitness on rich and synthetic media; null has decreased starvation resistance, increased thermotolerance, and decreased replicative lifespan that is increased relative to wt by caloric restriction; null contains large-budded cells with nuclear extensions at the nuclear envelope, adjacent to the nucleolus; homozygous null has a sporulation defect, and the heterozygous null is haploinsufficient




Gene Phenotype Experiment Type Mutant Information Strain Background Chemical Details Reference

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