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Elizabeth Mann

Postdoc Researcher in Gut T Cell Regulation

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths world-wide, for which a variety of genetic and environmental risk factors are known to exist. One molecule that is known to promote CRC in mouse models of disease is the Th17-family cytokine IL-22. In human CRC, levels of IL-22 are similarly elevated but it's function in disease progression remains poorly understood.

My research aims to uncover what drives the enhanced production of IL-22 in human CRC tumours alongside how IL-22 modulates the development and trafficking of different immune cells into the tumour.

Insights from these studies will hopefully inform the development of novel diagnostic assays and therapeutics for CRC, particularly focussing on subsets of patients that have poor prognosis.