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15 Possible Causes for Irritability, Profound Psychomotor Developmental Delay

  • Mental Retardation

    The cornea is the clear (transparent) outer layer of the eye, and has two functions – it protects the rest of the eye from dust, germs and other harmful or irritating material[] Three siblings in a consanguineous Pakistani family presented with profound developmental delay, severe ID, no speech, psychomotor delay, and postnatal microcephaly.[] But I'm glad to see that non-disabled people are beginning to understand why less offensive words such as 'special', 'brave' and 'wheelchair-bound' are so irritating to many[]

  • Horseshoe Kidney

    With urinalysis (a type of urine test), the doctor can quickly detect abnormalities (such as too many red blood cells) that may signal inflammation or irritation in the urinary[] Developmental and behavior In older children with trisomy 18 significant developmental delay is always present ranging from a marked to profound degree of psychomotor and[] Gastroesophageal reflux is a significant medical problem because of both its high prevalence and its potential consequences, like irritability, recurrent pneumonia and aspiration[]

  • Isolated Congenital Auditory Ossicle Malformation

    Common causes of conductive hearing loss include: [1] External ear [ edit ] Cerumen (earwax) or foreign body in the external auditory canal Otitis externa, infection or irritation[] Mental and psychomotor developmental delay was noted. Figure 1 The proband aged 18 months. (A, B) Note facial dysmorphism (see text). (C) He cannot stand unsupported.[] The irritation of the skin, and this is not due to the material, can also lead to an unusual thickening of the cutis.[]

  • Trisomy 8q

    Depending upon the age at symptom onset and other factors, associated symptoms may include sudden episodes of uncontrolled electrical activity in the brain (seizures), irritability[] Psychomotor retardation is always severe-to-profound.[] This can cause pain, irritability, and vomiting. Medication may be as well. In more severe cases, surgery may be required.[]

  • ANE Syndrome

    "Symptoms and Causes of Irritable Bowel Syndrome.". University of Maryland Medical Center. "Irritable Bowel Syndrome." Jan. 11, 2014.. Wald, Arnold.[] Multiple congenital malformations including developmental delay, brain malformations, skeletal anomalies, and facial deformities are ...[] "Beast and Belle begin their love story really irritating each other and really not liking each other very much," she said.[]


    Short middle fifth phalanges, [11] sometimes causing short and wide fingers. [12] Vertebral abnormalities. [11] On rare occasions, brachial plexus irritation can occur. [7[] delays; microcephaly developing during the first year of life; moderate to profound psychomotor retardation; progressive retinochoroidal dystrophy and high myopia; neutropenia[] Short middle fifth phalanges, [14] sometimes causing short and wide fingers. [15] Vertebral abnormalities. [14] On rare occasions, brachial plexus irritation can occur. [10[]

  • Cerebellar Hypoplasia and Atrophy

    Restlessness Adducted thumb Abnormality of the periventricular white matter Opisthotonus Generalized seizures Chorea Dyskinesia Lower limb spasticity Narrow palate Gliosis Irritability[] If these babies survive the fetal period, PCH clinically manifests as profound psychomotor retardation, developmental delay, problems with movement, and a variable cerebral[] Major management difficulties included sleep disorder and severe irritability, most prominent in the first 3 years of life, unrelated to gastro-oesophageal reflux.[]

  • Thyro-Cerebro-Renal Syndrome

    Abstract A 58-year-old male presented with fever, nausea, and vomiting since 15 days along with irritability and confusion since 5 days.[] ., sitting up, crawling, walking, and other developmental milestones) and a profound delay in the attainment of skills requiring the coordination of muscular and mental activity[] The affected patients present with hypocalcemia, which causes neuromuscular irritability.[]

  • Hyperphosphatasia with Mental Retardation Syndrome 4

    Triad of irritability , soft tissue swellings and cortical thickening of underlying bone is typical.[] Definition An autosomal recessive neurologic disorder characterized by profound developmental delay, severe mental retardation, no speech, psychomotor delay, postnatal microcephaly[] Aniridia Genitourinary problems Retardation Wilms tumor Pseudohermaphroditism Progressive glomerulonephritis First six months Soft tissue swelling, periosteal reaction, irritability[]

  • Ectodermal Dysplasia - Syndactyly Syndrome

    Allergies, irritants, your genetic makeup, and certain diseases and immune system problems can cause rashes, hives, and other skin conditions.[] Multiple congenital malformations including developmental delay, brain malformations, skeletal anomalies, and facial deformities are ...[] Use cautiously with gastrointestinal irritation or peptic ulcer disease due to anecdotal reports of gastrointestinal irritation.[]

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