@article {Ramsingh7278, author = {Ramsingh, A I and Collins, D N}, title = {A point mutation in the VP4 coding sequence of coxsackievirus B4 influences virulence.}, volume = {69}, number = {11}, pages = {7278--7281}, year = {1995}, publisher = {American Society for Microbiology Journals}, abstract = {In analyzing the molecular determinants of virulence of coxsackievirus B4, chimeric viruses were constructed from avirulent and virulent viruses. The vCB424 recombinant contained a single nucleotide substitution on an avirulent genetic background, resulting in replacement of Ser-16 of VP4 with Arg-16. Mice infected with vCB424 displayed an intermediate phenotype.}, issn = {0022-538X}, URL = {https://jvi.asm.org/content/69/11/7278}, eprint = {https://jvi.asm.org/content/69/11/7278.full.pdf}, journal = {Journal of Virology} }