Researchers have identified a protein complex that marks misfolded proteins, stops them from interacting with other proteins in the cell and directs them towards disposal. They have identified the so-called Linear Ubiquitin Chain Assembly Complex, Lubac for short, as a crucial player in controlling misfolded proteins in cells. The group is hoping to find a new therapeutic approach to treat neurodegenerative diseases such as Alzheimer's, Parkinson's or Huntington's chorea, all of which are associated with misfolded proteins.