Abstract Title:

Bioactive Ginger Constituents Alleviate Protein Glycation by Trapping Methylglyoxal.

Abstract Source:

Chem Res Toxicol. 2015 Aug 6. Epub 2015 Aug 6. PMID: 26247545

Abstract Author(s):

Yingdong Zhu, Yantao Zhao, Pei Wang, Mohamed Ahmedna, Shengmin Sang

Article Affiliation:

Yingdong Zhu


Considerable evidence suggests that long-term pathological diabetes is a result of the accumulation of tissue macromolecules that have been progressively modified by non-enzymatic glycation of protein. Methylglyoxal (MGO) is a highly reactive endogenous dicarbonyl metabolite derived from multiple sources such as glucose and lipids, and is considered to greatly contribute to protein glycation and the formation of advanced glycation end products (AGEs). In this study, we demonstrated for the first time that both [6]-shogaol (6S) and [6]-gingerol (6G), the major active components in ginger, markedly trapped MGO in vitro and consequently formed mono-MGO adducts, 6S-MGO and 6G-MGO, which were purified from the respective chemical reaction and characterized as novel compounds by NMR experiments and LC-MS/MS approaches. We revealed that theα-carbon of carbonyl group in the side chain of 6S or 6G is the major active site for trapping MGO. We also demonstrated that 6S and 6G could effectively inhibit the formation of MGO-induced AGEs via trapping MGO in a time-dependent manner in the human serum albumin (HSA)-MGO system. Mono-MGO adducts, 6S-MGO and 6G-MGO, were determined to be the major conjugates in 6S- and 6G-treated HSA-MGO assays, respectively, using LC-ESI/MS techniques. These findings showed the potential effects of 6S and 6G on the prevention of protein glycation, suggesting regular consumption of ginger root extract mayattenuate the progression of MGO-associated diabetic complications in patients.

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