@article {Senger983, author = {Senger, DR and Galli, SJ and Dvorak, AM and Perruzzi, CA and Harvey, VS and Dvorak, HF}, title = {Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid}, volume = {219}, number = {4587}, pages = {983--985}, year = {1983}, doi = {10.1126/science.6823562}, publisher = {American Association for the Advancement of Science}, abstract = {Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors.}, issn = {0036-8075}, URL = {https://science.sciencemag.org/content/219/4587/983}, eprint = {https://science.sciencemag.org/content/219/4587/983.full.pdf}, journal = {Science} }