TY - JOUR T1 - Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of β-catenin mRNA JF - Journal of Cell Science JO - J. Cell Sci. SP - 1352 LP - 1362 DO - 10.1242/jcs.056176 VL - 123 IS - 8 AU - Bikkavilli, Rama Kamesh AU - Malbon, Craig C. Y1 - 2010/04/15 UR - http://jcs.biologists.org/content/123/8/1352.abstract N2 - Canonical Wnt/β-catenin signaling is crucial during embryonic development. Upon Wnt stimulation, Dishevelled proteins relay the signal from upstream Frizzled receptors to downstream effectors. By using affinity purification followed by ion-trap mass spectrometry we identified K-homology splicing regulator protein (KSRP) as a novel Dishevelled-interacting protein. We show that KSRP negatively regulates Wnt/β-catenin signaling at the level of post-transcriptional CTNNB1 (β-catenin) mRNA stability. Thus, Dishevelled-KSRP complex operates in Wnt regulation of β-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability. ER -