92 results found
    1. Cell Biology

    Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2

    Adela Constantinescu-Bercu et al.
    1. Immunology and Inflammation

    Critical role of WNK1 in MYC-dependent early mouse thymocyte development

    Robert Köchl et al.
    Development of mouse thymocytes through the pre-TCR checkpoint requires WNK1 kinase signalling via the OXSR1 and STK39 kinases and the SLC12A2 ion co-transporter leading to MYC-dependent cell proliferation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hemozoin produced by mammals confers heme tolerance

    Rini H Pek et al.
    1. Cell Biology
    2. Genetics and Genomics

    A trans-eQTL network regulates osteoclast multinucleation and bone mass

    Marie Pereira et al.
    MMnet is a conserved, trans-regulated gene network that controls skeletal homeostasis through osteoclast multinucleation and bone resorptive function.
    1. Genetics and Genomics
    2. Neuroscience


    François Kroll et al.
    Zebrafish knockouts can be generated in a few hours directly from wild-type eggs and are suitable for studying continuous traits, including behaviour.
    1. Genetics and Genomics
    2. Immunology and Inflammation


    Kenneth T Farabaugh et al.
    Changes in the interactome of the Rel family of transcription factors control adaptation to the environmental stress of hyperosmolarity and determine cell fate.
    1. Cell Biology

    Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

    King Faisal Yambire et al.
    Impaired lysosomal acidification results in retention of iron inside lysosomes, triggering functional iron deficiency, dysfunctional mitochondria (especially mtDNA loss), and inflammation in vivo in a mouse model of lysosomal disease.
    1. Cancer Biology
    2. Cell Biology

    The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

    Margaret E Torrence et al.
    ATF4 is a metabolic effector of mTORC1 signaling, co-opted to induce gene targets involved in amino acid synthesis, uptake, and tRNA charging, contributing to mTORC1-driven protein and glutathione synthesis.
    1. Cell Biology

    Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis

    Skye C McIver et al.
    1. Computational and Systems Biology
    2. Developmental Biology

    Size control of the inner ear via hydraulic feedback

    Kishore R Mosaliganti et al.

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