BEGIN:VCALENDAR PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3- M3//EN VERSION:2.0 CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT DTSTAMP:20200922T172311Z DTSTART:20200923T090000Z DTEND:20200923T100000Z SUMMARY:Richard Clarke - Understanding the role of the endothelial glycoc alyx: a brush-like coating on the walls of blood vessels UID:{}g10f-kfcaun nz-dzajsj DESCRIPTION:Richard Clarke (University of Auckland) joins us for this vir tual seminar in the Physical Applied Mathematics Series\n\nThis seminar will be held via Zoom. Please email if y ou require the meeting details.\n\nAbstract: The Endothelial Glycocalyx Layer (EGL) is a thin\, brush-like layer that coats the inside of the v asculature. It is believed to serve as a protective barrier against exce ssive fluid shear\, as well as perform a number of other biological func tions\, such as mechanotransduction. The fragile nature of the EGL\, how ever\, makes it very difficult to examine experimentally\, and so theore tical models can provide interesting and useful insights. In the past th e EGL has been modelled as an isotropic\, homogeneous porous layer. Howe ver\, there is an increasing volume of evidence to suggest that the EGL has a microstructural organisation that brings in to question this assum ption. In this talk I will explain some of our work using Homogenisation Theory to explore the connection between EGL microstructure and its bul k macroscopic properties. The EGL also carries a net negative charge\, a nd consequently interacts with ions dissolved in the blood flow\, creati ng a Debye layer at the EGL interface. This in turn can lead to electrok inetic effects\, which our models suggest can also have important ramifi cations for the transmission of mechanical stresses to the wall.\n\n STATUS:TENTATIVE TRANSP:TRANSPARENT CLASS:PUBLIC LOCATION:Via Zoom. END:VEVENT END:VCALENDAR