2021-05-12T01:17:51Z https://digital.csic.es/dspace-oai/request
oai:digital.csic.es:10261/87875 2019-03-18T15:14:45Z com_10261_41 com_10261_1 col_10261_294
Estarás, Conchi Akizu, Naiara García, Alejandra Beltrán, Sergi Cruz, Xavier de la Martínez-Balbás, Marian 2013-11-29T11:34:24Z 2013-11-29T11:34:24Z 2012 Development 139(15): 2681-2691 (2012) http://hdl.handle.net/10261/87875 http://dx.doi.org/10.1242/dev.078345 http://dx.doi.org/10.13039/100008666 http://dx.doi.org/10.13039/501100003339 Neural development requires crosstalk between signaling pathways and chromatin. In this study, we demonstrate that neurogenesis is promoted by an interplay between the TGFβ pathway and the H3K27me3 histone demethylase (HDM) JMJD3. Genome-wide analysis showed that JMJD3 is targeted to gene promoters by Smad3 in neural stem cells (NSCs) and is essential to activate TGFβ-responsive genes. In vivo experiments in chick spinal cord revealed that the generation of neurons promoted by Smad3 is dependent on JMJD3 HDM activity. Overall, these findings indicate that JMJD3 function is required for the TGFβ developmental program to proceed. eng openAccess Epigenetic regulation JMJD3 (Kdm6b) Smad3 TGFβ pathway Neurogenesis Histone demethylation Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program artículo