@article{ashaduzzaman2016, author = {Ashaduzzaman, Md and Al-Rafin, Abdullah and Mustary, Nusrat and Md Shamsuddin, Sayed}, title = {Studies on Interaction of Lidocaine Drug with Natural Cellulosic Fibres}, year = {2016}, month = {8}, volume = {4}, pages = {36--46}, journal = {International Journal of Pharmacology, Phytochemistry and Ethnomedicine}, doi = {10.18052/www.scipress.com/IJPPE.4.36}, keywords = {Adsorption, Absorption Spectroscopy, Desorption, Drug Interaction, Self-Assembly}, abstract = {Naturally engineered cellulosic fibres are of particular interest due to their diverse interfacial behavior; which could be well suited to operating interaction with functionalized drug. In the present work, interaction of Lidocaine (LC) hydrochloride, 2-(diethylamino)-N-(2,6-dimethylphenyl) acetamide was widely studied with cellulosic fibres i.e. cotton, jute and coir in presence of 0.1M HCl aqueous solution. In UV-Vis spectroscopy measurement, it is revealed that the highest interaction (adsorption 18 mg/g of fibres) of LC was occurred onto the cotton fibres surfaces from 3.5 mg/mL aqueous solution after 30 minutes gentle shaking. Kinetic studies in case of cotton fibres showed a linear relationship (R2 = 0.9987) during desorption of LC upto 30 minutes at 25 °C temperature. The cotton fibres concentration was to be calculated 0.0085 g unit mol/L by considering the unit molecular weight of glucose unit. When 2.5 mg/mL (0.0108 g mol/L) LC drug solution was used then the ratio between glucose unit and LC drug was found to be 1.27. The interaction of LC was also increased direct-proportionally to the weight of cotton fibres. The resulting interaction phenomena of model LC would help us to deign dosage of anesthetic drug for specific physiological conditions.} }