Genetics of Bone Biology and Skeletal Disease - John Eisman, Michael P. Whyte, Rajesh V. Thakker | Consegna Gratis

Genetics of Bone Biology and Skeletal Disease

Genetics of Bone Biology and Skeletal Disease
titolo Genetics of Bone Biology and Skeletal Disease
autori , , ,
argomenti Medicina Genetica Malattie genetiche
Medicina Genetica
Medicina Ortopedia
editore Academic Press Inc
formato Libro
pagine 878
pubblicazione 2017
ISBN 9780128041826
18app Carta del docente Acquistabile con bonus 18app o Carta del docente
160,00 152,00 (-5%)
Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets.

Indice testuale

Part 1: General Background to Bone Biology Part 2: General Background to Genetics Part 3: Disorders of Bone and Joint Part 4: Parathyroid and Related Disorders Part 5: Vitamin and Renal Disorders

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