Determinants of progression from secondary progressive multiple sclerosis to relapsing remitting multiple sclerosis


  • As assessed by magnetic resonance imaging (MRI), cortical lesions and atrophy primarily distinguish secondary progressive multiple sclerosis (SPMS) from relapsing remitting multiple sclerosis (RRMS) after 30 years.

Why this matters

    No biomarker has been found that correlates with long-term multiple sclerosis (MS) disability levels or that can distinguish between SPMS and RRMS. This study has identified cortical involvement as a determinant of disability and progressive disease, suggesting that cortical lesions and atrophy could be a target for future MS therapies.