How harmless gut bacteria 'turn bad'

Greater Kashmir

Researchers have determined how harmless E.coli gut bacteria in chickens can easily pick up the genes required to evolve to cause a life-threatening infection.

The study, published in the journal Nature Communications, warns that such infections not only affect the poultry industry but could also potentially cross over to infect humans.

“Previously we thought that E. coli became pathogenic by acquiring specific genes from other bugs, often packaged in mobile elements called plasmids. But our study compared the genomes of disease-causing and harmless E. coli in chickens and found that they can ‘turn bad’ simply by picking up genes from their environment,” said Sam Sheppard from the University of Bath in the UK.



“That increases the likelihood of bacteria picking up genes that could help the bacteria survive and turn infectious, or even jump species to infect humans,” he added. E. coli is a common bacterium that lives in the intestines of most animals, including humans. It is usually harmless when it stays in the gut, however, it can become very dangerous if it invades the bloodstream, causing a systemic infection that can even lead to death.