A PLAG1 mutation contributed to stature recovery in modern cattle

Licia Colli, Paolo Ajmone Marsan, Marco Sannazaro, Elisa Eufemi, Yuri Tani Utsunomiya, Adam Taiti Harth Utsunomiya, Rafaela Beatriz Pintor Torrecilha, Eui-Soo Kim, Márcio Silva Costa, Tamíris Sayuri Aguiar, Steven Schroeder, Adriana Santana Do Carmo, Roberto Carvalheiro, Haroldo Henrique Rezende Neves, Romulo Cláudio Morozini Padula, Thayla Souza Sussai, Ludmilla Balbo Zavarez, Rafael Silva Cipriano, Maria Margareth Theodoro Caminhas, George HambrechtMaurizio Buora, Michele Morgante, George Liu, Derek Bickhart, Curtis Paul Van Tassell, Johann Sölkner, Tad Stewart Sonstegard, José Fernando Garcia

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23 Citazioni (Scopus)


The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of â¼1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16thand 18thcenturies. Towards the 19thand 20thcenturies, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait.
Lingua originaleEnglish
pagine (da-a)17140-N/A
RivistaScientific Reports
Stato di pubblicazionePubblicato - 2017


  • Multidisciplinary

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