Lab 8

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    • A. Basophil
    • B. Lymphocyte
    • C. Monocyte
    • D. Eosinophil
    • E. Immature Neutrophil
    • F. Neutrophil
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    • A. Eosinophil
    • B. Neutrophil
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    • A.Monocyte
    • B. Lymphocyte
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    This is sickle cell anemia in sickle cell crisis. The abnormal hemoglobin SS is prone to crystallization when oxygen tension is low, and the RBC's change shape to long, thin sickle forms that sludge in capillaries, further decreasing blood flow and oxygen tension.
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    Iron Defiency Anemia

    The RBC's here are smaller than normal and have an increased zone of central pallor. This is indicative of a hypochromic (less hemoglobin in each RBC) microcytic (smaller size of each RBC) anemia.
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    Microangiopathic Hemolytic Anemia (MAHA)

    There are numerous fragmented RBC's seen here. Some of the irregular shapes appear as "helmet" cells. Such fragmented RBC's are known as "schistocytes" and they are indicative of a microangiopathic hemolytic anemia (MAHA) or other cause for intravascular hemolysis
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    Hemoglobin SC Disease

    In the center of the field is a rectangular RBC that is indicative of Hemoglobin SC disease. Both hemoglobin S and hemoglobin C are present. The RBC's may sickle, but not as commonly as with Hemoglobin SS disease. The hemoglobin C leads to the formation of "target" cells--RBC's that have a central reddish dot.
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    Acute Lymphocytic Leukemia (ALL)

    The WBC's seen here are lymphocytes, but they are blasts--very immature cells with larger nuclei that contain nucleoli. Such lymphocytes are indicative of acute lymphocytic leukemia (ALL). ALL is more common in children than adults. Many cases of ALL in children respond well to treatment, and many are curable
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    Chronic Lymphocytic Leukemia (CLL)

    These mature lymphocytes are increased markedly in number. They are indicative of chronic lymphocytic leukemia, a disease most often seen in older adults. This disease responds poorly to treatment
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    Megaloblastic Anemia

    Here is a hypersegmented neutrophil that is present with megaloblastic anemias. There are 8 lobes instead of the usual 3 or 4. Such anemias can be due to folate or to B12 deficiency. The size of the RBC's is also increased
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    Hereditary Spherocytosis

    The size of many of these RBC's is quite small, with lack of the central zone of pallor. These RBC's are spherocytes. In hereditary spherocytosis, there is a lack of spectrin, a key RBC cytoskeletal membrane protein. This produces membrane instability that forces the cell to the smallest volume--a sphere.
Card Set
Lab 8