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Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock
The role of individual receptors such as the toll-like receptors and CD14 in the induction of proinflammatory cytokines and adhesion molecules is discussed in detail and the therapies for the treatment of bacterial sepsis and septic shock are discussed in relation to the action of these receptors and proteins. Expand
Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.
The optimally chemically modified siRNA-GalNAc conjugates are hepatotropic and long-acting and have the potential to treat a wide range of diseases involving liver-expressed genes. Expand
The peripheral blood mononuclear cell microRNA signature of coronary artery disease.
The present study is the first to show that microRNA signatures can possibly be utilized to identify patients exhibiting atherosclerotic CAD in general and those at risk for acute coronary syndromes. Expand
The blood-brain barrier in neuroinflammatory diseases.
The existence of the blood-brain barrier (BBB)bwas revealed through studies by [Ehrlich (1885)][1] in the late 19th century, describing that brain tissue remained unstained after injection of a vitalExpand
FTY720, a Synthetic Sphingosine 1 Phosphate Analogue, Inhibits Development of Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice
The present results demonstrate that an S1P analogue inhibits atherosclerosis by modulating lymphocyte and macrophage function, and these results are consistent with the notion that S 1P contributes to the antiatherogenic potential of high-density lipoprotein. Expand
Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development.
It appears that, depending on the stage of atherosclerotic lesion development, SR-BI in bone marrow-derived cells is either pro-atherogenic or anti-atherogensic, indicating a unique dual role in the pathogenesis of Atherosclerosis. Expand
Different fate in vivo of oxidatively modified low density lipoprotein and acetylated low density lipoprotein in rats. Recognition by various scavenger receptors on Kupffer and endothelial liver
The liver contains an additional specific Ox-LDL receptor which is highly concentrated on Kupffer cells, which will form the major protection system against the occurrence of the atherogenic Ox- LDL particles in the blood. Expand
Determination of the Upper Size Limit for Uptake and Processing of Ligands by the Asialoglycoprotein Receptor on Hepatocytesin Vitro and in Vivo *
A novel glycolipid is synthesized, which possesses a highly hydrophobic steroid moiety for stable incorporation into liposomes, and a triantennary GalNAc3-terminated cluster glycoside with a high nanomolar affinity for the ASGPr. Expand
Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2.
It is demonstrated that shear stress and KLF2 inhibit nuclear activity of ATF2, providing a potential mechanism by which endothelial cells exposed to laminar flow are protected from basal proinflammatory, atherogenic gene expression. Expand
Genetic variant of the scavenger receptor BI in humans.
Reduced SR-BI function was associated with altered platelet function and decreased adrenal steroidogenesis, and a family with a functional mutation in SR- BI was identified. Expand