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2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014

Vitamin D receptor gene polymorphisms and the risk of Parkinson's disease.

Neurol Sci. 2014 Aug 29. [Epub ahead of print]
Chunlei Li (1); Huiping Qi (2); Shuqin Wei (3); Le Wang (4); Xiaoxue Fan (4); Shurong Duan (4)
Sheng Bi bisheng13224510036 at 163.com (4)
1. Department of Rehabilitation, The First Affiliated Hospital, Harbin Medical University, 150001, Harbin, China
2. Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, 150001, Harbin, China
3. Saint-Justine Research Center, University of Montreal, Montreal, Canada
4. Department of Neurology, The First Affiliated Hospital, Harbin Medical University, 150001, Harbin, China

Reminder about Vitamin D Receptor

A vitamin D blood test can tell you that you have a high level of vitamin D, but the Vitamin D receptor gene modifications will reduce the efficiency of getting vitamin D to the cells.

394 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells


There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphone and perhaps sulfurVitamin D Receptor


Pages listed in BOTH the categories VDR and PD

The effect of vitamin D receptor (VDR) gene polymorphisms on Parkinson's disease (PD) has recently gained interest. However, evidence on this relationship is controversial. We searched PubMed, EMBASE and the Cochrane Library database targeted all studies that evaluated VDR gene polymorphisms and PD up to April 2,014. A meta-analysis was conducted on the association between VDR ApaI, BsmI, TaqI and FokI polymorphisms and PD using (1) allelic contrast, (2) dominant, (3) recessive, and (4) additive models.

A total of five relevant studies involving PD patients (n = 1,266) and controls (n = 1,649) were included in the analysis. There was a significant association between FokI polymorphism and PD.
In the pooled allelic analysis, the

  • F allele was associated with increased risk of PD (OR 1.41, 95 % CI 1.14-1.75).

In the genotype analysis,

  • FF + Ff versus ff showed a significant association with PD in the dominant model (OR 2.32, 95 % CI 1.49-3.61, P = 0.0002).

FF versus ff showed a significant association with PD in the additive model (OR 2.45, 95 % CI 1.52-3.93, P = 0.0002).
There was also a statistically significant association between VDR BsmI polymorphisms in the recessive model,

  • BB versus Bb + bb showed a significant increased risk of PD (OR 1.37, 95 % CI 1.01-1.87, P = 0.04).

No significant associations were observed between VDR ApaI and TaqI polymorphisms and PD.

To sum up, VDR BsmI and FokI polymorphisms were associated with increased risk of PD.

PMID: 25169913

Publisher wants $45 for the PDF


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