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Abstract #3219

The mechanical signature of the dying brain

Gergely Bertalan1, Jürgen Braun2, Stefanie Schreyer3, Barbara Steiner3, Charlotte Klein3, Angela Ariza1, Eric Barnhill1, Ingolf Sack1, and Jing Guo1

1AG Elastography, Experimental Radiologie, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Institue for Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany

In this study the mechanical properties of the mouse brain were continuously sampled by fast magnetic resonance elastography during ketamine/xylazine induced dying. Mechanical properties were correlated with metabolic and physiological imaging markers. Immediately after respiration arrest, stiffness of the whole brain and the hippocampus increased significantly while cardiac functioning was intact and reached a plateau ca. 5 min after ECG stop. Stiffness increase was inversely correlated with diffusion decrease. Results suggest that during the process of dying cytotoxic edema and brain swelling occurs leading to significant tissue stiffening.


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