Based on human clinical trial data, our lead drug called Berubicin, which was developed at a leading U.S. comprehensive cancer center, has been shown to get across the blood brain barrier and kill brain tumor cells not reachable by other therapies. In other words, Berubicin may become an effective treatment against glioblastoma, the most aggressive type of brain cancer.

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This is a scan of a patient’s glioblastoma in Berubicin’s Phase 1 clinical trial where 44% of the patients showed a clinical response. Berubicin is one of the first anthracycline’s that does not require a specific carrier to be able to cross over the blood brain barrier and get into the brain. None of the drugs that require carriers have been shown to be effective in humans.

The image on the left is pre-treatment and the one on the right is 6-months post-treatment.

Our Lead Drug, Berubicin, was Developed at a Leading U.S. Comprehensive Cancer Center.

What is Glioblastoma?

Glioblastoma is the most aggressive type of brain cancer, where the average survival is only 14 to 16 months after diagnosis – essentially a death sentence for those afflicted with it. Glioblastoma is the type of brain cancer that led to the death of Senator Ted Kennedy, Vice President Joe Biden’s son and most recently, the passing of Senator John McCain. It’s important to understand that there is currently no proven cure for this aggressive disease.

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What are Anthracyclines?

Anthracyclines are among the most effective anticancer treatments ever developed, and have played a prominent role in the treatment of more types of cancer than any other class of chemotherapeutic agents. According to academic literature, Anthracyclines have demonstrated anti-tumor activity in a wide range of cancers including breast, stomach, uterine, ovarian, bladder, lung and hematological malignancies.

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What is the Blood Brain Barrier?

The blood brain barrier is a protective wall of specialized endothelial cells that separate the blood from the brain tissue. The blood brain barrier was beautifully designed to protect the brain from foreign substances that could harm the brain like anthracyclines and other chemotherapy agents.

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