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Sural Nerve Biopsies in Pediatric Neurological Disorders

The results of sural nerve biopsies in 18 patients with disorders of the nervous system are reported. Involvement of the peripheral nerves was found histologically in some cases in which this was not suspected clinically or from electrodiagnostic examination. Peripheral nerve involvement was found not only in metachromatic leukodystrophy but also in a miscellaneous group of patients with nervous involvement characterized by hypotonia and in some with polymyositis. It is suggested that sural nerve biopsy, which is well tolerated by children, should find a place in the investigation of patients with neuromuscular and other neurological disorders even in the absence of clinical or electrodiagnostic evidence of peripheral nerve involvement.