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PATHOLOGY OF SUDDEN CORONARY DEATH *

Sudden and unexpected death from coronary heart disease has been a major health problem throughout the world, especially in industrialized countries. Although progress has been made in determining the pathogenetic sequence of events leading to coronary heart disease and sudden death, many aspects of the process are still unknown. In our experience, most of these sudden deaths occur outside of the hospital or very shortly after the person's arrival. Autopsy materials from typical hospital-based studies do not include much of the information needed for a more complete description of the natural history of the disease. Our team of investigators has been studying atherosclerosis, coronary heart disease, and sudden death from a high percentage of all 25-44-year-old men dying in a well-delineated geographic location during a specified time period. This community-wide survey was designed to include men dying both inside and outside of hospitals. A large number of heart specimens, collected from young men dying of all causes, was examined by a team of pathologists according to a standardized protocol which required objective evaluation of findings and uniform application of definitions. This report focuses on the findings in sudden and not-sudden deaths from coronary heart disease in this 10-year study.