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[Effect of antioxidants on the activity of liver glutathione-S-, glucuronyl- and sulfurtransferases in rats].

It was shown that pretreatment of rats with antioxidants (AO) butylhydroxytoluene and 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride owing to its effect of animal protection against intoxication with diethylnitrosamine (DENA) increases the liver activity of enzymes of stage II metabolism of xenobiotics: glutathione-S-transferase (GST), UDP-glucuronyltransferase (UDP-GT). Administration of DENA (LD50) produced a significant decrease of the activity of GST and UDP-GT as compared with that in intact animals. At the same time its action on the animals pretreated with AO develops against the background of increased activity of these enzymes.