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ANALYSIS OF TIMP-1 AND NM 23 GENES IN GLIOMA CELL INVASION ( ABSTRACT ) *

Purpose: To evaluate using transcription analysis the presence and importance of two genes: NM23-H1 and TIMP-1 on control of tumor cell invasion in diffuse astrocytomas (WHO II) and glioblastoma multiforme (WHO IV ). Method: N o rt h e rn Blot analysis of NM23-H1 and TIMP-1 was performed. Eight diffuse astrocytomas and nineteen glioblastomas (WHO IV) were analyzed to det e rmine if TIMP-1 and NM23-H1 were candidates to inhibition of tumor cell invasion quantitated RNA levels. The samples were collected directly from operating room. Total cellular RNA was extracted from frozen tissue samples using guanidinium-isothiocyanate and cesium chloride gradients. Total RNA (10μl per sample) from tumor tissue were size fractionated through 1% a g a ro s e f o rmaldehyde gels and transferred to nylon filters and then hybridized to 32P-labeled DNA probes THESES