{'fraction_non_alphanumeric': 0.020370370370370372, 'fraction_numerical': 0.009259259259259259, 'mean_word_length': 5.212643678160919, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
The acute effects of tolbutamide on forearm metabolism.

ABSTRACT Studies of tolbutamide in vitro have indicated an antilipolytic effect and stimulation of glucose uptake; however, a direct effect on peripheral tissue metabolism in vivo in man has not been fully investigated. The forearm perfusion technique was used to study the peripheral effects of 60-min infusions of tolbutamide as compared to insulin or tolbutamide with insulin in fasting, normal volunteers. Forearm blood flow and systemic arterial insulin concentrations were unaltered during the experiments. Infusions of tolbutamide alone in 5 subjects producing forearm arterial concentrations of 108 μg/ml plasma transiently decreased forearm glucose uptake and increased potassium efflux but had no effect on arterio-deep venous differences (A-DV) for free fatty acids or R.Q. Infusions of insulin alone in 5 subjects enriching forearm arterial concentrations by 73 μU/ ml increased glucose uptake 7-fold, caused a net gain of potassium and increased the A-DV difference for free fatty acids suggesting decreased...