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Morphological and Functional Changes Immediately After Half-Time Photodynamic Therapy in Patients With Central Serous Chorioretinopathy.

BACKGROUND AND OBJECTIVE
To evaluate early treatment outcomes of half-time photodynamic therapy (PDT) in patients with central serous chorioretinopathy (CSC).


PATIENTS AND METHODS
The anatomical and functional results were assessed for 24 eyes of 23 patients with CSC treated with half-time PDT in this prospective case series. Central foveal thickness (CFT) and subfoveal choroidal thickness (SCT) were evaluated by spectral-domain optical coherence tomography (SD-OCT), and mean retinal sensitivities and fixation characteristics were evaluated by MP-1 microperimetry at baseline and 1 day, 3 days, 1 week, 1 month, and 3 months after treatment.


RESULTS
Observations 1 day after treatment revealed an increase in both SCT and CFT and a decrease in retinal sensitivity (P = .013; P = .02; and P = .02, respectively). The CFT significantly resolved 1 month after treatment (P = .002), and the SCT significantly resolved 7 days after treatment (P = .011). Although an immediate decrease in retinal sensitivity was observed at post-treatment day 1 (P = .02), the greatest reduction in retinal sensitivity was observed 3 days after treatment(P = .009), and then a tendency to increase was seen at subsequent visits.


CONCLUSIONS
Despite early anatomical and functional impairments, such as an increase in CFT and SCT and a decrease in retinal sensitivity immediately after half-time PDT, best-corrected visual acuity and retinal sensitivity improved significantly 3 months after treatment. Half-time PDT is associated with early transient deterioration, but not with permanent adverse effect in patients with CSC. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:932-940.].