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The expression of CDK4 protein in astrocytoma

Objective To discuss the expression of CDK4 gene in astrocytoma , and the relationship between it and pathological classification. To discuss the CDK4 gene proteins' functions among the astrocytomas' occurence and development.Methods A S-P immunohistrochemical technique is undertaken to detect the location, the quantity and the positive expression rate of CDK4 gene in 33 human brain astrocytomas.Results The CDK4 gene's expression in Astrocytomas groups are all higher than in nomal control group. CDK4 is mainly located in cell cytoplasm. There exist CDK4 gene abnormal expression in astrocytomas, the positive rate of CDK4 gene exist remarkable difference between different grade (P0.05), besides there exist CDK4 overexpression in 3 low-grade gliomas while exist in all the high-grade gliomas.Conclusion there exist overexpression of CDK4 gene in astrocytoma,the overexpression have relation with the astrocytoma's occurrence and development, the overexpression of CDK4 can direct the pathological grade.