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ANSWERS AND EXPLANATIONS TO SELF‐ASSESSMENT

1. The answer is B, lamellar ichthyosis (non-bullous congenital ichthyosiform erythroderma or CIE). Neither ichthyosis vulgaris nor atopic dermatitis produces skin manifestations until the third month or later. Epidermolytic hyperkeratosis (bullous CIE) is often associated with bullae. Histologically, bullous CIE is characterized by vacuolization of epidermal cells; these contain abnormal large keratohyaline granules. Lamellar ichthyosis is generally present at birth. Affected children are called collodion babies (lamellar exfoliation of the newborn). Other types of ichthyosis may also rarely have a collodion membrane.