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A COMPARISON OF SERUM HEAT STABLE ALKALINE PHOSPHATASE AND URINARY OESTROGEN EXCRETION IN THE MOTHER AS PLACENTAL FUNCTION TESTS

The serum heat stable alkaline phosphatase (HSAP) was assayed using strict criteria to measure only the placental iso‐enzymes in a group of normal pregnant women in order to establish the normal range. One hundred patients with complica‐tions of pregnancy had paired serum HSAP and urinary oestrogen assays performed serially. Serum HSAP determinations were found to be of no use in predicting fetal distress, the Apgar score at birth, or fetal dysmaturity. Serial assays of urinary oestrogen output enabled dysmaturity to be correctly predicted in 72.4 per cent of cases, but there was also an incidence of 21.1 per cent false positive predictions. Urinary oestrogen assays were less reliable in predicting fetal distress or a low