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Delayed-type hypersensitivity induced by bovine nasal cartilage proteoglycan in guinea pigs.

The immunization of guinea pigs with 3 mg of bovine nasal cartilage proteoglycan, A1D1, in complete Freund's adjuvant (CFA) induced a delayed-type hypersensitivity (DTH) and a macrophage migration inhibition (MI) activity of peritoneal exudate cells (PEC). To assess the antigenic determinants of A1D1 in the DTH response, we examined the DTH response of guinea pigs immunized with A1D1 in CFA, using five different kinds of antigens: A1D1 digested with chondroitinase ABC, with trypsin, or with pronase, as well as authentic chondroitin sulfate and keratan sulfate. A1D1 digested with chondroitinase ABC or trypsin produced DTH responses and an MI activity on PEC. On the other hand, pronase digestion of A1D1 significantly suppressed both the DTH response and MI activity on the PEC. Authentic chondroitin sulfate and keratan sulfate, however, induced neither DTH responses nor MI activity. We have therefore concluded that the antigenic determinants of A1D1 for cellmediated immunity reside not in the glycosaminoglyc...