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Species differences in cellular processing of siRNA‐Lipid complex

Lipid‐based nanocarriers provide a means to deliver nucleic acid therapeutics such as short interfering RNA (siRNA); a major challenge is the low success rate in preclinical‐to‐clinical translation. siRNA gene knockdown depends on its ability to reach the intracellular target RISC (RNA Induced Silencing Complex, degrades the targeted mRNA), and is hence determined by the kinetics of multiple cellular processes (see below). The present project used experimental and computational studies to investigate the species differences in the processing of siRNA‐lipid complex (Lipoplex).