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Adiponectin Attenuates NLRP3 Inflammasome by Modulating AMPK-ROS Pathway

Adiponectin is an adipocyte-derived cytokine that exerts antidiabetic and anti-atherogenic properties and has been shown to enhance insulin sensitivity and promote lipid metabolism in obesity-linked diseases through the anti-inflammatory action. However, the detail mechanism of the anti-inflammatory effect of adiponectin remains unknown. In the present study, we found that in 50 patients with newly diagnosed type 2 diabetes (T2D), the circulating levels of adiponectin correlate inversely with IL-18 (r = -0.64, P Disclosure F. Wang: None. L. Wang: None. Y. Liu: None. J. Yuan: None. Z. Mo: None.