{'fraction_non_alphanumeric': 0.04772079772079772, 'fraction_numerical': 0.03347578347578348, 'mean_word_length': 5.565420560747664, 'pattern_counts': {'":': 0, '<': 3, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Effects of 17‐hydroxyprogesterone caproate (17‐OHPC) administration to pregnant squirrel monkeys (Saimiri boliviensis boliviensis)

Poor reproductive performance of the squirrel monkey (Saimiri boliviensis boliviensis) in captivity and a relative progesterone (P) deficiency in pregnancy have been reported. Since premature births may contribute to pregnancy wastage, we attempted to measure the effectiveness of 17‐hydroxyprogesterone caproate (17‐OHPC) treatment of pregnant squirrel monkeys to prevent early deliveries. Based on clearance studies of nonpregnant animals, 25 mg of 17‐OHPC was administered at 6‐day intervals to a test group of 31 pregnant monkeys while the control group of 29 received saline. Venous blood was obtained at 6‐ to 12‐day intervals for measurement of 17‐hydroxyprogesterone (17‐OHP), P, 17‐B estradiol (E), and androstenedione (A), and dihydroepiandrosterone (DHEA) levels by radioimmunoassays. The treated group had a significant increase in serum 17‐OHP (P < 0.001), P (P < 0.01), and DHEA (P < 0.05) levels compared to controls. The numbers of live births, stillbirths, or neonatal deaths did not differ significantly between groups. Although 17‐OHPC administration appeared to increase P and 17‐OHP levels, this did not alter the duration of pregnancy nor delay the onset of labor. A significant fall in 17‐OHP, P, and E levels was observed 6–12 days before delivery.