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Neuronal electrical activity, energy consumption and mitochondrial ATP restoration dynamics: A physiological based model for FMRI

fMRI is a widely used method to detect the activated brain regions due to a stimulus application. Commonly, it employs the BOLD contrast, which is based on the correlation between physiological function, energy metabolism and haemodynamics. However, the BOLD signal is weak and noisy, so that, an accurate mathematical model to describe the Haemodynamic Response Function (HRF) to activation is needed.