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Focus Issue: Signaling Lipids

Membranes are dynamic and specific contributors to cell signaling. Cellular membranes play a key structural role in creating sites for the formation of signaling complexes. Changes in membrane phospholipids can regulate the activity of transmembrane and peripheral membrane proteins. Modification of membrane lipids can result in formation of dynamic signaling molecules. Science's STKE highlights new insights into the roles that lipids and membranes play in cell signaling.