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ABC of colorectal diseases. Colorectal neoplasia--II: Large bowel cancer.

Carcinoma of the large bowel is a common malignancy. It is predominantly a disease of older people, though it may occur at any age. Less than 5% of patients are under the age of 40 and more than half are over 60, with the peak incidence in people aged 70-80. There are about 25 000 new cases each year in the United Kingdom, and it is second only to cancer of the bronchus as a cause of death from cancer, with an annual mortality of about 19 000. There is no noticeable sex difference; in women it is less common than carcinoma of the breast. There has been no significant change in mortality from large bowel cancer over the past 40 years and half the cases present beyond surgical cure.