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Brain biopsy in children with primary small‐vessel central nervous system vasculitis

Primary angiitis of the central nervous system in childhood (cPACNS) is an immune‐mediated inflammatory process directed toward blood vessels in the central nervous system. It has been associated with variable clinical and radiological presentations, and devastating consequences without treatment. Brain biopsy is required for definitive diagnosis. The objective of this study was to characterize the clinical and histopathological features of brain biopsies in small‐vessel cPACNS (SVcPACNS).