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Effects of blood pressure on white matter lesions and brain volumes in hypertensive and normotensive subjects

There is a direct relationship between cardiovascular dysfunction and risk factors and the development of the diseased brain. Such an affiliation has been made clear by decades of comprehensive studies associating poor cardiovascular health with adverse neurological events such as stroke, brain atrophy, and dementia. Hypertension and its subsequent pathological hallmarks can ultimately lead to cognitive dysfunction such as Alzheimer’s disease. Although benefits of hypertension (HTN) treatment are indisputable, the target blood pressure value remains under debate.