{'fraction_non_alphanumeric': 0.016877637130801686, 'fraction_numerical': 0.004219409282700422, 'mean_word_length': 4.968553459119497, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Thickening of arterial intima in rat cardiac allografts. A light and electron microscopic study.

THE THICKENING OF THE INTIMA OF THE ARTERIES of organ grafts during chronic rejection is a process that has been well recognized for several years. It has been seen in cardiac,1' renal,34 and hepatic 5 grafts, both in patients and in experimental animals. It is of great importance to determine the pathogenesis of this intimal thickening as it is often the cause of ischaemic damage and failure of the long-term organ graft. In this paper, the light and electron microscopic appearances of the intimal thickening occurring in the coronary arteries of cardiac allografts are described. The experimental model used was the untreated heterotopic cardiac graft between two inbred strains of rat. A sequence of events that occurs after endothelial damage and that leads to intimal thickening, with narrowing of the coronary arterial lumens, is suggested.