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Investigating HSF1‐Mediated Interactions of Human Angiogenin with Chromatin

Angiogenin (ANG) is a pancreatic‐type secretory ribonuclease that was identified for its ability to promote new blood vessel growth. More recently, ANG has been implicated in neurodegeneration, inflammation, and reproduction, revealing its broad biological roles. The goal of our work is to understand the molecular activities of human ANG. During sustained growth of cultured human cells, ANG interacts with chromatin to upregulate rDNA transcription. Recent work in our lab demonstrates that ANG interacts with heat shock transcription factor 1 (HSF1). Our work is aimed at expanding our knowledge of ANG interactions with the human genome and determining if ANG works cooperatively with HSF1 to regulate stress‐response genes. Using chromatin immunoprecipitation (ChIP) sequencing, we have identified genomic targets of ANG biding and characterized the co‐regulation of heat shock genes by ANG and HSF1.