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[The changes of density of platelet glycoprotein (GP) II b/III a receptor in the perioperative period of gastrectomy in aged rats].

AIM
To investigate changes of density of platelet glycoprotein (GP) II b/III a receptor in the perioperative period of gastrectomy in aged rats.


METHODS
The subtotal gastrectomy operation was performed in 16 adult rats and 16 aged rats respectively. Platelet surface density of GP II b/III receptors were determined by flow cytometric analysis before and 6, 12, 24, 48, 72 hours after operation.


RESULTS
6, 12, 24, 48 and 72 hours after operation, the density of GP II b/III a in aged group increased continuously compared with preoperative period (6h, 12, 72: P < 0.05; 24, 48: P < 0.01).


CONCLUSION
Gastrectomy can lead to an increase of density of platelet GP II b/III a receptor in aged rats.