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Analysis of Age‐Related Impairments in Learning and Memory in Rodent Models

A sound demographic basis supports the increased need for animal models of memory dysfunction associated with human aging. Industrialized nations are experiencing a rapid growth in the aged segments of their populations. For example, over the last half of this century, the proportion of the U S . population over 65 years of age will grow from 8% to over 12% with projected increases up to 17% by the year 2030.’ This trend carries the potential for proportional and absolute increases in persons suffering from some type of memory impairment. These dysfunctions can range in severity from the subtle decrements observed among healthy, elderly individuals’ to the marked deficits observed among individuals diagnosed as having senile dementia of the Alzheimer