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Editorial: Pertussis: current problems, challenges and investigations of a re-emerging disease.

It is an honor to act as editor for this thematic issue of Pathogens and Disease focusing on pertussis, also known as whooping cough (http://femspd.oxfordjournals.org/content/thematic-issue-pertussis). Pertussis is caused by acute respiratory infection with the bacterial pathogen Bordetella pertussis , with some cases caused by the related pathogen B. parapertussis . The number of pertussis cases was dramatically reduced by introduction of the whole cell pertussis vaccine during the last century, but since introduction of less reactogenic acellular vaccines over the last 20 years, the number of cases has risen substantially in several countries. In 2012, the U.S. had the highest number of pertussis cases since 1955 (just a few years after introduction of the whole cell vaccine). Pertussis is probably the only vaccine-preventable …