{'fraction_non_alphanumeric': 0.03063557384545039, 'fraction_numerical': 0.00823045267489712, 'mean_word_length': 5.287356321839081, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Amoebic colitis rapidly diagnosed by endocytoscopy

A COMBINATION OF several diagnostic methods is generally used for the accurate diagnosis of amoebic colitis, namely, a combination of colonoscopic findings, microscopic examination of stool, and histopathologic findings of biopsy specimens. However, the sensitivity of these examinations is poor (60%). A recent study reported the use of endocytoscopy with approximately 5209 magnification as a diagnostic technique (e.g. CF-H290ECI; Olympus, Tokyo, Japan). A 38-year-old man with a history of fever and diarrhea with mucous and blood for 1.5 years was admitted to a hospital. Colonoscopy revealed multiple erosions in the rectum, and his symptoms were alleviated by using antimicrobial agents. Two weeks later, he visited a nearby hospital with right lower abdominal pain, and his symptoms improved with re-administration of the antimicrobial agent. Thereafter, he was referred to our hospital because of a positive fecal occult blood test. Colonoscopy revealed multiple dirty erosions and ulcers with white coats and reddish mucosa in the sigmoid colon, rectum, and cecum (Fig. 1). Endocytoscopy showed several floating and migrating amoebic trophozoites by ultra-high magnifying observation. On switching to the narrow-band imaging mode, the trophozoites were more clearly highlighted and easier to observe (Fig. 2a,b; Video S1). On the same day, a speculum examination of feces from the rectum revealed the presence of amoeboid dysentery, leading to the diagnosis of amoebic colitis (Fig. 2c). Histological findings showed numerous trophozoites stained one nucleus (Fig. 2d). Endocytoscopy is a potential diagnostic device used without biopsy in cancer and is attracting attention as a real-time diagnostic tool. It is a technique that accurately diagnoses amoebic colitis cases that are considered false negative based on conventional examinations such as hematoxylin and eosin staining, periodic acid-Schiff staining, and serum antibodies. Endocytoscopy can directly detect the presence of parasites around a lesion in vivo, reducing the number of false-negative results. Authors declare no conflict of interest for this article.