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Clinical and immunologic factors associated with the presence or absence of airways hyper‐responsiveness in childhood asthma

Background During the baseline period of a clinical trial comparing different dosage schedules of inhaled steroids, asthmatic children (aged 6–10 years) were expected to meet the inclusion criterion of airways hyper‐responsiveness (PD20 methacholine < 80 µg) after withdrawal of inhaled corticosteroids for 2–8 weeks. However, many children failed to do so.