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Circular RNAs in Brain Disorders

Circular RNAs, a class of covalently closed transcripts, are generated from thousands of protein-coding genes or noncoding regions of the genome via non-canonical splicing, and serve as important controllers in a variety of biological events in eukaryotes. Emerging studies have shown that circular RNAs are enriched in animal brains, and involved in brain disorders. In this review, we will discuss recent progress on circular RNA biogenesis, nuclear export, stability control, molecular functions, and regulatory roles in brain functions.