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Isotype‐specific antibody responses to Haemonchus contortus in genetically resistant sheep

The kinetics of anti‐Haemonchus antibody responses in serum and faecal extracts of pasture‐reared, genetically resistant and random‐bred sheep infected with Haemonchus contortus were examined using an isotype‐specific ELISA. Anti‐Haemonchus antibodies of IgA, IgG1, IgG2 and IgM isotypes were detected in serum and faecal extracts of both resistant and random‐bred sheep after challenge infection. Serum IgG1 and IgA levels in resistant sheep were significantly higher than in random‐bred sheep between 10 and 31 days after infection. However, there were no differences in IgG2 and IgM antibody responses between the two genotypes. Faecal antibody responses to H. contortus showed a clear genetic effect with resistant sheep exhibiting higher IgA levels throughout infection and higher IgG1 levels between 24 and 31 days after infection. Furthermore, serum IgG1 and IgA, and faecal IgA responses were negatively correlated with faecal egg counts in both genotypes on 17, 24 and 31 days after infection. Together, these results are taken to indicate that anti‐parasite IgA and IgG1 antibodies may play an important role in genetically determined resistance of sheep to haemonchosis