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[Use of the magnitude of the histone-DNA ratio as a criterion for evaluating the functional activity of the cell genome].

Cytophotometry was used to demonstrate, on a variety of experimental models, that changes in the histone/DNA ratio after staining the cell nucleus (Feulgen, DNA) and histones (naphthol yellow S) reflect alterations in the cell functional status. This ratio may thus be used as a criterion for evaluation of cell genome functional activity which is needed in various biological and medical problems.