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Intracellular pathogens convert macrophages from death traps into hospitable homes

Intracellular pathogens - bacteria, parasites and fungi - frequently infect macrophages in addition to other cells. They turn these deadly cells into harmless hosts to multiply and paralyze immunity. Understanding the complex mechanisms underlying this phenomenon may have a strong impact to identify new targets belonging to the pathogens but also to the host, thereby allowing the design of new therapeutic strategies.