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[Nature of intercellular interactions at various stages of post-transplantation immunity].

The paper presents the results of studies on the nature and frequency of intercellular interactions at various stages of posttransplantation immunity done by means of the grating microscope. The study was carried out in inbred mice. The donors of the skin included CBA mice (for the syngeneic system) and BALB/c mice (for the allogeneic system), and the recipients were CBA mice. The target cells were epidermal cells of the tails of mice of the appropriate lines. The interaction of the target cells with lymphocytes, thymocytes and macrophages obtained from the animals sensitized with the appropriate transplant were examined at various intervals after transplantation. The frequency and the nature of intercellular contacts were found to vary in relation to the time after grafting and the species of the graft. Numerous arches, bridges, outgrowths and microvilli were formed both between killer cells and immunocompetent cells and between lymphoid and non-lymphoid cells.