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PHARMACOLOGIC THERAPY OF DYSTROPHY IN MAN AND ANIMALS *

General remarks about the pharmacologic therapy of dystrophy appear, at first glance, to be an easy task, because there is no established or confirmed drug that will either stop progression or reverse the disease. On the other hand, over the years there have been a surprisingly large number of compounds that various investigators have reported as being effective, which have then fallen out of favor and atrophied by disuse. This phenomenon requires review, if for no other reason than to attempt to reduce the number of future studies that are destined for a similar fate. In addition, there are several newer drugs, some of which will be discussed in this monograph, that show promise but that have not yet been fully evaluated. Lastly, it is hoped that this review of general approaches to drug therapy may be of help in designing future studies.