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Small cryotherapy devices for the treatment of skin warts

Abstract Study purpose: Effectiveness of cryotherapy on skin wart models. Materials and methods: Two small cryotherapy devices, Wartner and Wortie, were administered for 10″–60″ on tomatoes and potatoes used as skin wart models. Frozen surface and depth were evaluated by standardized photography and computer analysis. Tissue temperature at depths of 0.1–10 mm was assessed by an electronic thermometer during treatment. Results: Cryotherapy induced a transient freezing of the tomato surface. The devices produced similar tomato tissue temperature reduction at all depths examined. At 5 mm, Wortie induced lower tissue temperatures than Wartner. Both devices induced potato tissue destruction to a depth of 0.5–1.2 mm at 40″ and 50″. Wartner induced a maximum destruction at 40″, Wortie led to a partially linear destruction depth with freezing time. The devices produced similar reduction of potato tissue temperature at all depths tested. Wartner induced more rapidly lower temperatures (1.5 mm, 10″, p = .001). Wortie induced lower tissue temperatures with time (0.1 mm, 50″, p = .025; 60″, p = .039; 5 mm, 60″, p = .05). None of the devices reached the lethal temperature of −22 °C. Conclusions: Both cryotherapy devices produced sufficient tissue damage, at least in the potatoes, to a depth of 0.5–1.2 mm when applied for 40″ (commercially proposed time).