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CHRONOTHERAPEUTICS: A RANGE OF NEWER DRUG DELIVERY APPROACHES FOR BETTER PATIENT COMPLIANCE

A major objective of chronotherapy in the treatment of several diseases is to deliver the drug in higher concentration during the time of greatest need according to the circadian onset of the disease or syndrome. The physiology and biochemistry of a human being is not constant during the 24 hours, but it shows some variability in a predictable manner as defined by the timing of peak and trough of each of the body circadian processes and functions in relation to the time. There are quite a few approaches are in progress to control the drug to the desired degree to the clinical physiology of diseases with the aid of single unit and multiparticulate systems. The chronotherapy of a medication may be accomplished by the judicious timing of conventionally formulated tablets and capsules are of current interest.