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Adverse Cardiac Events , and Infarct Size In Anterior Myocardial Infarction : An Analysis of INFUSE-AMI RCT # NCT 00976521

Background: Women are more likely than men to experience adverse cardiac events after ST-elevation myocardial (STEMI). Whether differences in infarct size or reperfusion contribute to sex differences in outcomes is unknown. Methods: We compared baseline and procedural characteristics, angiographic and electrocardiographic indices of reperfusion, microvascular obstruction, infarct size, and clinical outcomes in 118 women and 334 men with anterior STEMI enrolled in the INFUSE-AMI randomized trial of intralesion abciximab and aspiration thrombectomy (NCT00976521). Infarct size was assessed by cardiac magnetic resonance imaging at 30 days, and clinical end points were adjudicated by independent committee. Results: Women were older, more commonly affected by hypertension and renal impairment, and had a 50.5-minute longer delay to reperfusion. There were no differences in infarct size, microvascular obstruction, or reperfusion success. At 30 days, major adverse cardiac events (MACE), defined as death, reinfarction, new-onset severe heart failure or rehospitalization for heart failure, were more common in women (11.1% vs. 5.4%, hazard ratio: 2.09, 95% confidence interval: 1.03–4.27, p=0.04). After multivariable adjustment, age, but not sex or time to reperfusion, was an independent predictor of MACE. Conclusions: In the INFUSE-AMI randomized trial, women with anterior STEMI experienced a higher rate of MACE, attributable to older age. Despite longer delay from symptom onset to reperfusion therapy, there was no difference between women and men in infarct size or reperfusion success.