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INTRADERMAL AND INTRAMUSCULAR PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) VACCINATION IN PIGLETS: CHANGES OF PERIPHERAL LYMPHOCYTE SUBPOPULATIONS.

Introduction Porcine Reproductive and Respiratory Syndrome virus (PRRSV) causes reproductive failure in sows and respiratory disorders in pigs frequently associated with multiple infections (viruses, Mycoplasma and bacteria). Several experiments have been performed to investigate the humoral and cellular immune response during PRRSV infection in pig (1, 5, 6, 7, 8, 9). In spite of the observation that the exposure to the virus induces a protective immunity against re-exposure to the homologous virus, it has been also demonstrated that infected pigs developed a prolonged viremia and a persistent infection in lymphoid tissue and that they can become reinfected to the heterologous virus. These evidences testify the variable features of PRRS immune response and the consistent discrepancy between the experimental and field observations about the efficiency of the immune response, such as the supposed immunosuppressive role of PRRSV or the possible vaccine failure (2). Experimental and field results confirmed that the interaction between the pig immune system and PRRS virus is complex and that the current knowledge on innate and adaptive immune response is almost incomplete. This paper aims at providing further contribution to the study of PRRSV immunity by the investigation into the peripheral lymphocyte subpopulations by flow cytometric analysis as markers after PRRS vaccine administration by differential routes.