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Radiation induced coronary heart disease.

The heart was considered to be a relatively radioresistant organ by radiotherapists in the 1950s when data on normal tissue tolerance were sparse. Radiation techniques evolved with field arrangements that resulted in the maximum dose being received by the anterior mediastinal structures with a progressive fall posteriorly, which afforded maximal sparing of the dose to the spinal cord. The ensuing reports of cardiac complications included pericardial effusion, constriction, and tamponadel which were radiation induced.