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Conserved functions of the cytoplasmic domains of integrin beta subunits.

In this article I will discuss the notion that many integrins have similar functions in cell spreading, organization of the cytoskeleton and intracellular signalling. Most of these functions are transmitted through the cytoplasmic domains of integrin beta-subunits. These parts are also quite conserved between most integrins. I will discuss, what is known about the molecules binding to these parts of integrins, and which of those transmit the conserved functions.