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Perception of changes in airflow resistance in obstructive pulmonary disorders.

The perception of changes in airflow resistance was examined in normal subjects, asthmatics, and patients with chronic obstructive pulmonary disease (COPD) using the psychophysical tests of just noticeable differences and magnitude estimation. The just noticeable difference in airflow resistance expressed as a percentage of the baseline resistance (JND%) was 18 ± 2% SE in normal subjects and this value was not altered by changes in baseline resistance. The exponent for the magnitude estimation (ME) of airflow resistance was 0.93 ± 0.04 SE in normal subjects. Neither JND% nor ME were significantly different from normal in asthmatics. However, in patients with COPD, JND% was increased to 49 ± 7% SE (p < 0.01) and ME was reduced to 0.64 ± 0.10 SE (p < 0.01). In contrast to the abnormalities in the perception of changes in airflow resistance, the perception of heaviness during the lifting of small weights was the same in patients with COPD as in normal subjects and asthmatics. Measures of the perception of ch...