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Human adrenal tissue in vitro: steroidogenic properties.

ABSTRACT The characteristics of the steroidogenic response of human adrenal tissue were studied in an in vitro automated superfusion system. The time course of the response of human adrenal tissue to ACTH was identical with that previously shown for the rat. Human adrenal tissue was more sensitive to human ACTH than to porcine ACTH. The response to ACTH by human adrenal tissue depended upon the total dose of ACTH and not upon the concentration in the medium; on the other hand, the response of human adrenal tissue to cAMP was dependent upon the concentration in the medium. Human adrenal tissue remained sensitive to ACTH stimulation after 15 hr of superfusion. These results with human adrenal tissue support the current theories on the mode of action of ACTH and suggest that data obtained from experiments with rat adrenal tissue may be directly applied to the human adrenal.