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Retinoic acid regulates the activity of satellite cells and promotes skeletal muscle regeneration impaired due to obesity in mice

Ectopic lipid accumulation in skeletal muscle induced by obesity leads to muscle atrophy and impaired regenerative capacity. Retinoic acid (RA) has been reported to enhance myogenesis in embryonic stem cells and promotes regeneration in adult skeletal muscle. However, the effects of RA on muscle regeneration impaired due to obesity have not been addressed. The objective of this study is to explore the effects of RA on activation and myogenic differentiation of satellite cells (SCs) in obese mice, which promote muscle regeneration.