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A new estimate of the thyroxine binding globulin capacity.

A readily available estimate of the serum thyroxine binding globulin capacity (TBG) which reflects its concentration in a variety of clinical situations is desirable. The triiodothyronine resin uptake (T3U) and the serum thyroxine iodine (T4I), two of the most commonly employed tests in the evaluation of thyroidal disease, may be used to derive a new index of the TBG, the TBG estimate, defined as TBGE = 1/T3U + (T4I)1/4. The TBGE correlates very highly with measured TBG values and is a good predictor of TBG in a variety of conditions. Thus, two indices of physiologic significance—the free thyroxine index and the thyroxine binding globulin estimate—may be calculated simply from the T3U and T4I, and have direct applicability in the evaluation of the clinical status of the patient and the interpretation of laboratory results.