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Systemic Reactions with Total Dose Infusion of Iron Dextran Complex in Obstetric Patients

Iron dextran complex (Imferon) total dose infusion (TDI) was used to treat iron deficiency anemia in 310 obstetric patients. Systemic reactions were reported for 13.5% of the group. Most (90.5%) of the severe reactions occurred during the test dose, while 66.6% recorded during or after TDI were mild. Antihistamine premedication included administration of promethazine hydrochloride to 104 patients and intramuscular and intravenous drip chlorpheniramine hydrogen maleate to 206 patients. Total systemic reactions were statistically greater with intramuscular promethazine hydrochloride than with intramuscular and intravenous chlorpheniramine maleate (p<0.001). On the other hand, the rates of severe reactions and reactions during the test dose were similar for both antihistamine schedules (p>0.05). The incidence of all systemic reactions was the same for pregnant and postnatal women (p>0.05), but severe reactions were more frequent among pregnant than postnatal patients (p<0.001). There were no fatalities.