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The role of ependyma in regeneration of the spinal cord in the urodele amphibian tail

The new spinal cord formed during tail regeneration in te newt first develops as a caudal extension of the ependymal tube. Neuroblasts and neuroglia subsequently differentiate from cells of the ependymal tube in a proximal‐caudal sweep. Descending axons from the cord rostral to the lesion and from newly differentiating neurons travel in channels which are present prior to the ingrowth of axons. The present study confirms previous observations from our laboratory and presents details of the ultrastructural relations of axons and ependymal processes within the cord.