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[Changes in the hepatocytes of adult male rats subjected to the action of 3,4-benzopyrene at different periods of ontogeny].

The effects of benzpyrene (BP) were studied in 32 male Wistar rats. Treatment of intact mature animals with benzpyrene causes transformations of hepatocytes. Antenatal treatment with BP initiates a complex of compensatory-adaptational reactions in the liver of progeny and the effect retains at the postnatal period. The combined ante- and postnatal administration of the toxic drug makes the liver prepared to liquidate the effect of the pathogenic action with the help of a complex of compensatory mechanisms with qualitative changes in cell metabolism.