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Covid-19 and The Jade Screen Project-supporting frontline workers with Chinese herbal medicine.

Introduction: The Jade Screen Project (JSP) was initiated in March 2020 by Chinese herbal medicine (CHM) practitioners to help support UK frontline workers in the prevention, treatment and recovery from Covid-19. Methods: The JSP Management group was formed in March 2020. A selective review was conducted of available English and Chinese language sources describing the diagnosis and treatment of COVID-19. Data on herbs, formulae and approaches to management were extracted, formulated into statements, and circulated to an international group of expert practitioners. Agreement on these were rated on a 7 point Likert scale and aggregated to generate a broad consensus on good practice resulting in preventative and acute treatment guidelines. Forty-eight CHM practitioners were recruited to work voluntarily on the project and trained in the use of the guidelines. Funds were raised to enable provision of free herbs. Practitioner networks and social media were used to publicise the project. Results: Currently the JSP has 140 patients registered for treatment (74 for prevention, 6 for acute infection, and 60 for recovery). Recruitment has been primarily by word-of-mouth and includes a geographically and ethnically diverse population with a wide range of occupations from bus driver to surgeon. Data are being collected quantitatively using a modified MYMOP outcome measure and via in-depth qualitative interviews. Preliminary data suggests that CHM may have a useful role in assisting in the recovery from chronic COVID-19 related disease. Conclusion: The JSP is an example of a practitioner led initiative to provide accessible integrative care to a vulnerable population at a time of great need. It has generated treatment guidelines, created a network of trained practitioners, and provided free herbal treatment to a diverse group of CHM naive people. Preliminary data suggest further research into the role of CHM to assist recovery from chronic COVID-19 infection is warranted Keywords: Chinese herbal medicine;COVID-19;Integrative care;Prevention;Treatment


Introduction:
Effective treatment for patients with the novel Coronavirus Disease  is desperately needed and is under rigorous research. Nigella sativa oil (NSO), a herbal medicine, that has a documented wide antiviral and immunomodulatory activities offering a therapeutic potential for COVID-19.
Methods: Adult symptomatic patients with mild COVID-19 were recruited between May and August 2020 from King Abdulaziz University Hospital in Jeddah, Saudi Arabia. They were randomly assigned to receive supplementation with oral capsules of NSO (MARNYS' Cuminmar 500 mg twice daily for 10 days) plus standard of care or standard of care medications alone. The primary endpoint was the proportion of patients recovered (free of symptoms for 3 days) within 14 days after randomization. This trial was registered with clinicaltrials.gov, NCT04401202.
Results: A total of 120 patients were enrolled. Their mean age was 35 (SD = 11) years old and 57% of them were male. There were 60 patients in the treatment group (NSO) and 60 patients in the control group. The proportion of patients recovered in the treatment group was significantly higher than the control group, 42 (70%) versus 27 (45%) (p = 0.006). Additionally, there was a significant difference in the average recovery time among both groups, 9.9 (SD = 3.3) versus 11.6 (SD = 3.4) days (p = 0.006). Furthermore, 3 patients from the control group required hospitalization within the study period versus one in the treatment group. Adverse events were reported in 3 patients of NSO recipients as gastrointestinal symptoms.
Conclusion: In this RCT of adult patients with mild COVID-19, NSO was associated with a significant increase in the likelihood of recovery and a decrease in the likelihood of hospitalization. To our knowledge, this is the first RCT that shows potential therapeutic benefits of NSO in patients with COVID-19 which requires further confirmation with larger double-blinded RCTs.
Keywords: Black seed, Nigella sativa, COVID-19, SARS-CoV-2; randomized controlled trial Methods: The JSP Management group was formed in March 2020. A selective review was conducted of available English and Chinese language sources describing the diagnosis and treatment of COVID-19. Data on herbs, formulae and approaches to management were extracted, formulated into statements, and circulated to an international group of expert practitioners. Agreement on these were rated on a 7 point Likert scale and aggregated to generate a broad consensus on good practice resulting in preventative and acute treatment guidelines. Forty-eight CHM practitioners were recruited to work voluntarily on the project and trained in the use of the guidelines. Funds were raised to enable provision of free herbs. Practitioner networks and social media were used to publicise the project.
Results: Currently the JSP has 140 patients registered for treatment (74 for prevention, 6 for acute infection, and 60 for recovery). Recruitment has been primarily by word-of-mouth and includes a geographically and ethnically diverse population with a wide range of occupations from bus driver to surgeon. Data are being collected quantitatively using a modified MYMOP outcome measure and via in-depth qualitative interviews. Preliminary data suggests that CHM may have a useful role in assisting in the recovery from chronic COVID-19 related disease.
Conclusion: The JSP is an example of a practitioner led initiative to provide accessible integrative care to a vulnerable population at a time of great need. It has generated treatment guidelines, created a network of trained practitioners, and provided free herbal treatment to a diverse group of CHM naive people. Preliminary data suggest further research into the role of CHM to assist recovery from chronic COVID-19 infection is