{'fraction_non_alphanumeric': 0.02710413694721826, 'fraction_numerical': 0.025677603423680456, 'mean_word_length': 4.801652892561983, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Kinetics of intravenous amoxicillin in patients on long‐term dialysis

The kinetics of intravenous amoxicillin was studied in 8 patients with creatinine clearances of less than 7 ml/min who were on long‐term hemodialysis. Kinetic parameters were determined using a 2‐compartment linear model. The serum half‐life (t½) of amoxicillin in these patients ranged from 7.5 to 21 hr. The t½ fell to 2.84 ± 0.45 hr during dialysis. Approximately 30% of the dose was recovered in the dialysate during 4 hr of dialysis and there was a 25% reduction per hour in serum concentration. We present a dosage schedule for intravenous amoxicillin in patients with reduced renal function who are undergoing hemodialysis.