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Analysis of affinity of monoclonal antibody responses by inhibition of plaque‐forming cells

It has been suggested that dominant monoclonal responses in mice after transfer of small numbers of spleen cells are the result of strong selection for cell clones producing antibody of high affinity. We have attempted to measure the affinity of anti‐DNP (2,4dinitrophenyl) and anti‐NIP (4hydroxy5iodo3nitrophenacetyl) antibodies produced in monoclonal responses by inhibition of plaque‐forming cells (PFC) with free hapten. PFC from individual monoclonal spleen foci and from spleens after adoptive transfer of 5 × 105 to 2 × 106 primed spleen cells were generally inhibited at lower free antigen concentrations than the PFC found in a heterogeneous secondary response.