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A Novel Transcription Factor Regulates the Oxidative Stress Response in Caulobacter crescentus

All aerobically growing organisms have developed mechanisms for coping with oxidative stress. While the oxidative stress response has been well‐studied in some bacteria such as Escherichia coli, it is not as well‐characterized in other bacterial groups such as alphaproteobacteria. Here we examine the role of transcription factors in the oxidative stress response in Caulobacter crescentus. Using viability assays, we find that a deletion in the transcription factor CoxR leads to a strain that is more sensitive to hydrogen peroxide treatment but there are no obvious changes in viability in response to DNA damage agents such mitomycin C, and heat shock. Global gene expression and qRT‐PCR analysis suggested that the CoxR deletion strain has altered gene expression of NADPH cycling enzymes. In summary, CoxR is critical for the oxidative stress response.