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Adverse Biochemical and Physiological Effects of Metformin in Diabetic Type-2 Patients, A Comparative Clinical Study

Task: The aims and objectives of present study were to highlight the efficacy and adverse side effects of metformin in patients with diabetes type-2 and this study was conducted from December 2021to May 2022 in different medical and diabetic centers of Pakistan. Materials and methods: Subjects: 700 male and female subjects were selected for this study. Division of individuals: 100 normal individuals were in Control group, further 600 individuals were divided into three different groups. In group-X, 200 diabetic type-2, patients were taking 2000 mg/day metformin and in group-Y, 200 diabetic type-2, patients were taking 1500 mg/day metformin while in group-Z, 200 diabetic type-2, patients were taking 500 mg/day metformin respectively. Parameters: Fasting and random serum glucose levels, blood lactic acid levels, serum creatinine levels, myoglobin blood levels and blood hemoglobin levels. Analysis: Microlab and Spectrophotometry kit, regent method were used for the measurement of different parameters. Bio-statistical presentation: All collected raw data were interoperated bio-statistically through the application of SPSS version 2000, in which all parameters were described with the application of standard mean deviation and significant (p<0.05) regression.