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Assessment of Left Ventricular Systolic Function and Diastolic Time Intervals by the Bioimpedance Polyrheocardiographic System

Abstract: In order to detect left ventricular systolic function and diastolic time intervals using a new improved bioimpedance polyrheocardiographic system (BPCS), 110 healthy subjects and 128 patients with myocardial infarction were examined. Twenty‐four simultaneous measurements of cardiac output by thermodilution and BPCS were performed in 11 patients with complicated acute left ventricular failure. Studies demonstrated a high degree of correlation (r= 0.91, p < 0.001). The correlation between the methods of using signals of the second derivative and the subtracted first derivative waveform of BPCS and continuous‐wave Doppler echocardiography of systolic and diastolic time intervals was studied in 51 patients. The methods were closely correlated, especially with respect to left ventricular ejection time (r= 0.95), isovolumic relaxation time (r= 0.85), time to peak filling (r= 0.90), and deceleration of rapid filling time (r= 0.91). New bioimpedance hemodynamic parameters such as peak volume acceleration of ejection (PVAE) and peak power ejection (PPE) in patients with heart failure (NYHA Class I‐III) were studied. Significant reductions of PVAE and PPE in groups of patients with marked progression of heart failure were noted. These results have demonstrated that BPCS is a noninvasive, simple accurate method of assessment of left ventricular systolic function and diastolic time intervals.