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Synergistic effect of palmitate and nicotine treatments in diabetic heart (LB560)

Background: Metabolic disorders (hyperglycemia, dyslipidemia, hypertension) contribute to the development and progression of cardiovascular disease in individuals with type 2 diabetes. Risk factors such as obesity and cigarette smoking are also strongly associated with exacerbation of diabetes‐associated heart failure. Obesity is associated with hypertriglyceridemia and elevated circulating free fatty acids (FFA), result in endothelial dysfunction and heart failure. Recent findings have demonstrated that alterations in cardiac energy metabolism are primarily connected with the development of cardiomyopathy in the diabetic heart.