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Lysosomal activity in developing cat alpha‐motor axons under normal conditions and during retrograde axonal transport of horseradish peroxidase

The occurrence of acid phosphatase (AcPase)‐positive bodies, i.e., lysosomes, in lumbosacral alpha‐motor axons of kittens, 0–16 weeks of age, was analyzed by light and electron cytochemical methods under normal conditions and after intramuscular injection of horseradish peroxidase (HRP). Axonal lysosomes wore rare early postnatally. In 3‐week‐old animals, a few AcPase‐positive bodies appeared in the axoplasm at some nodes of Ranvier in the peripheral nervous system (PNS) and internodally in the intrafunicular motor axon parts within the central nervous system (CNS). From 6 weeks postnatally, a nodal concentration of AcPase‐positive bodies was also noted in the CNS. The number of AcPase‐positive bodies continued to increase gradually in the course of neuronal maturation. In 16‐week‐old animals, axonal AcPase activity was still at considerably lower levels than at adult stages. At all ages, acid hydrolase‐containing organelles were most commonly found at ventral root nodes. After injection of HRP in the medial gastrocnemius muscle, accumulations of AcPase‐positive bodies were seen in the axoplasm at some PNS nodes of the HRP‐injected sides of kittens aged 8, 12, and 16 weeks. Incubation for demonstration of both HRP and AcPase activity showed that some organelles at HRP‐transporting nodes contained both types of reaction product. The nodal AcPase activity in the intrafunicular, CNS parts of alpha‐motor axons of the HRP‐exposed sides did not differ from that of the contralateral, uninjected sides.