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Study on anti-inflammatory activity of a new series of tetracyclic carboxamides

The anti-inflammatory activity of a new series of tetracyclic carboxamides was modelled topologically using molecular redundancy (MRI), van der Waals volume (Vw), as well as equalised electronegativity (Χ c q ) indices. Simple linear regressions could not reflect, in totality, anti-inflammatory phenomenon. The predictive quality was discussed on the basis of cross-validated statistical parameters.