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Inhibitory activity of 2-aminooxazole derivatives against Coxsackie B1 virus in FL cells.

The antiviral activity of three-2-aminooxazoles was studied against coxsackie B1 virus in FL cells. The virus-induced cytopathic effect was nearly completely suppressed by two of the test compounds as revealed by spectrophotometric turbidity measurements. The plaque reduction amounted to 95--100 per cent. The compounds had no effect on extracellular virus or on absorption and penetration. The inhibition of infectious virus yield in one-step growth experiments reached 94--99.9 per cent. One of the compounds showed no inhibition of cellular RNA synthesis, whereas viral RNA synthesis was completely suppressed. The other two exerted only a small influence on cellular RNA synthesis. However, the results suggested an inhibition of uridine transport.