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[Effect of pH on blood cells].

Intracellular pH of blood cells is controlled by the Na+/H+ exchanger and anion channels. The Na+/H+ exchanger plays a major role in elevating intracellular pH in activated platelets, lymphocytes and neutrophils. In lymphocytes, intracellular alkalinization is associated with proliferation and differentiation. In platelets, protein kinase appears to increase the turnover rate of Na+/H+ exchange, thus accelerating the process of alkalinization. Intracellular alkalinization serves to increase the energy supply by glycolysis, and to activate the production of thromboxane A2, a potent activator of platelets. Clinically an increased activity of the Na+/H+ exchanger has been demonstrated with platelets from hypertensive patients.