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A quantitative comparison of t‐cell subsets in hodgkin's disease and reactive hyperplasia frozen section immunohistochemistry

Cryostat sections of lymph nodes from patients with Hodgkin's disease were stained with monoclonal antibodies reactive with T‐cells including T‐cell subsets. Lymph nodes showing reactive hyperplasia were used as controls. Using an eyepiece grid, the stained cells were counted and subset ratios determined. The ratio of helper T‐cells to cytotoxic/suppressor T‐cells, i.e., Leu‐3a/Leu‐2a or Leu‐1‐Leu‐2a/Leu‐2a in Hodgkin's disease was found to be significantly different from ratios obtained from reactive nodes. This difference may be explained by a relative increase in cytotoxic/suppressor T‐cells and/or a decrease in helper T‐cells. This finding may relate to the previously reported increase in suppressor cell activity in patients with Hodgkin's disease and may also correlate with diminished delayed‐type hypersensitivity in such patients.