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Inhibiting effect of somatostatin on growth hormone release induced by isoprenaline or chlorpromazine in rats.

Recent studies in animals have demonstrated that growth hormone (GH) secretion is controlled by GH releasing factor (GHRF) and GH inhibiting factor (somatostatin). Somatostatin has not only been purified from the ovine hypothalamus, but also synthesized (Brazeau, Vale, Burgus, Ling, Butcher, Rivier & Guillemin, 1973). It has been demonstrated recently that synthetic somatostatin suppresses the spontaneous secretion of GH and the increase in plasma GH induced by i.v. injection of pentobarbitone in the rat (Brazeau, Rivier, Vale & Guillemin, 1974). We have previously reported that a single i.v. injection of isoprenaline or chlorpromazine