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Rescue therapy with local intra‐arterial urokinase after poor clinical response with intravenous recombinant tissue plasminogen activator in acute ischaemic stroke

We report a case of combined intravenous and intra‐arterial thrombolysis in a patient presenting with acute ischaemic stroke. Progression to intra‐arterial thrombolysis in patients who fail to show clinical improvement within 6 h of symptom onset might be a safe treatment option at centres with access to stroke specialist and endovascular services. The purpose of this report is to demonstrate the efficacy and potential benefits of this rescue therapy.