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Ultrasonographic imaging of the sciatic nerve in a patient with knife injury

attenuate disease progression and stabilize the clinical picture in at least two-thirds of cases. The patient reported here shows that early ERT may be protective and, at certain stages of the disease, may reverse some of the laboratory and clinical signs of late-onset Pompe disease. This treatment may even allow competitive sports activity, including submaximal exercise, with careful monitoring. As residual muscle fragility remains present in affected patients, caution with respect to vigorous exercise remains mandatory, along with strict clinical and biochemical follow-up.