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Disease severity linked to increase in autoantibody diversity in IgG4-related disease: response to Shiokawa et al.

The letter by Shiokawa and colleagues thoughtfully reiterates key points that we had raised and discussed in our recent report. We had reported that the frequency of detectable antibodies to annexin A11 in a cohort of North American patients with IgG4-related disease (IgG4-RD) was similar to the previously described frequency of these antibodies in a European cohort. However, the frequency of antibodies against laminin 511-E8 in our cohort, even in patients with autoimmune pancreatitis, was considerably lower than that previously reported from Kyoto.