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Dorsal hippocampal surface reduction as a biomarker of neurodegeneration in subjects with subjective cognitive decline and MCI converters to dementia

Hippocampal atrophy has been proposed as the main neurodegeneration marker in the Alzheimer’s disease (AD) continuum. However, scarce research has found differences on that measure at early stages, i.e. subjective cognitive decline (SCD), and between mild cognitive impairment (MCI) patients that convert or not to AD. Here, we explored whether group differences emerged when other brain characteristics, as the white matter microstructure or the hippocampal surface shape, are used.