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EP06.14: The ratio of prenasal thickness and nasal bone length as a screening parameter for fetal abnormalities in the second and third trimester

distance was 2.73mm (SD 1.57). FS distance was dependent on CRL (FS=6.25-0.054*CRL, r=-0.256, p<0.001). Conclusions: During first trimester it is reliable to measure these markers by prenatal ultrasonography, such as IFA, MNM angle, FS distance, which represent fetal facial profile especially the relative position of maxilla and mandibular. The reference range of these markers are preliminarily constructed, which provide quantitative reference for the further diagnosis of fetal cleft lip and palate, micrognathia.