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Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO‐1 but induce an interferon response and cytotoxicity in central nervous system neurones

Knocking down neuronal LINGO‐1 using short hairpin RNAs (shRNAs) might enhance axon regeneration in the central nervous system (CNS). Integration‐deficient lentiviral vectors have great potential as a therapeutic delivery system for CNS injuries. However, recent studies have revealed that shRNAs can induce an interferon response resulting in off‐target effects and cytotoxicity.