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[Redistribution of gastrointestinal ammonia into blood in alcohol coma rat: the role in lethal outcome].

At 3 h after the intragastral administration of ethanol (446 mmol/kg) the blood ammonia concentration in v. portae increased 1.4 times, in v. cava inf. caudally of vv. renales inflow - 2.2 times, cranially of vv. hepaticae - 2.5 times, and in blood obtained by decapitation - by 65%7. The rate of ammonia accumulation in 'avage medium injected intraperitoneally was triple as that in intact rats. The exposure to atmospheric ammoniac (0.84-1.07 mg/l) for 3 h resuited in increasing blood ammonia concentration 2.4 times compared with the isolated ethanol action. The ammonia inhalation promoted the lethal action of ethanol with a dose alteration factor of 0.81 and suppressed gas-exchange. The promotion of the ethanol lethal action by the non-lethal ammonium acetate dosage has been observed. These data suggest that in rat, the coma-inducing ethanol ingestion promotes the translocation of intestinal ammonia into the common bloodstream, which has a detrimental effect on the outcome of alcohol coma.