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Absorption spectroscopy as a tool to control blood oxygen saturation during photodynamic therapy

The photodynamic therapy (PDT) is an effective method to treat cancer and other nononcological lesions by means of light action on photosensitizer in tissue. It is considered that destroying effect is mainly due to the formation of singlet oxygen resulting from the interaction of light excited photosensitizer with molecular oxygen (triplet state in the ground state). So the destroying effect will be proportional to the rate of singlet oxygen formation which is in turn depends on light intensity, photosensitizer concentration and molecular oxygen concentration. The present work deals with the investigation of blood oxygen saturation in microcircular vessels (SO2) during light irradiation in the PDT process. It has been observed that SO2 behavior strongly correlates with the light power density applied for PDT. The high power density resulted in sharp SO2 decrease. The connection of SO2 decrease with enhanced oxygen consumption rate and vessel destruction due to PDT is discussed.