{'fraction_non_alphanumeric': 0.032805429864253395, 'fraction_numerical': 0.011312217194570135, 'mean_word_length': 5.507352941176471, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Clinical pathology and treatment of renin-angiotensin system 2. Chronic kidney disease and the renin-angiotensin system.

Repeated renal biopsy in diabetic nephropathy after pancreas transplantation revealed that thickening of the glomerular basement membrane and mesangial expansion were normalized and nodular lesion disappeared after 10 years, but not after 5 years (1, 2). These findings prompted us to change our thinking that chronic renal failure is not necessarily irreversible, but rather, reversible. The recent clinical trial, Steno 2 (3), in fact showed that inhibition of the renin-angiotensin system (RAS) especially in the early stage of diabetic nephropathy normalizes albuminuria and regresses nephropathy (4). Now, we must pay attention that nephropathy can be recovered mainly by inhibition of RAS (5), returning the classical understanding of “point of no return”.