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Modeling of the Cirrhotic Liver Considering the Liver Lobule Structure

The human liver is composed of small hexagonal structures known as the liver lobules. In this paper, we propose a modeling technique for the change of the scatterer distribution on liver tissue considering the liver lobule structure to obtain cirrhotic liver images of the continuous stage. We calculate the squared difference between the Rayleigh distribution and the probability density of the echo amplitude of each cirrhosis image. The difference increases with the progression of cirrhosis. These results agree well with the results obtained from clinical liver cirrhosis images. It is found that the proposed modeling technique is valid for analyzing the relationship between the change of characteristics of biological tissue and change of B-mode image on the progression of liver cirrhosis.