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Probing the Binding Entropy of Ligand–Protein Interactions by NMR

The draft human genome sequence has revealed about 30 000–40 000 protein-coding genes in the human genome— roughly twice as many as in a fly. Thus, it follows that the complexity of higher organisms lies in part in the interactions between gene products. Despite their fundamental importance, it is perhaps therefore surprising that our knowledge of the driving forces that govern biomolecular interactions is very rudimentary. For example, our ability to predict protein folds from sequence (an intramolecular-recognition problem) is currently a distant dream, as is our ability to design novel leaddrug candidates from high-resolution structures of target biomolecules.