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Regulation of c-erbA-α Messenger RNA Species in Tadpole Erythrocytes by Thyroid Hormone

Putative thyroid hormone (TH) nuclear receptors have been detected in several tissues of Rana catesbeiana tadpoles. T3 receptor number (sites per nucleus) in red blood cells (RBCs) and tail increases substantially just before metamorphic climax or in response to exogenous TH; in contrast, receptor number in liver remains relatively constant. TH receptors in mammals and birds are thought to be encoded by a c-erbA gene. In the present study, two c-erbA cDNAs, one prepared from Xenopus laevis oocytes (XenTRα1) and one prepared from Rana catesbeiana tail (RC12), were used to examine the c-erbA-related mRNA species in Rana catesbeiana tissues and determine their role in the TH induction of tadpole RBC receptor number. XenTRα1 encodes a protein with T3-binding properties typical of TH receptors. RC12 is almost 99% homologous with XenTRα1, at the amino acid level and contains all of the putative T3-binding region and most of the DNAbinding region. Using either cDNA as a probe, it was found that two major species...