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Role of RNA‐binding protein HuR and CUGBP1 in LPS‐induced Interleukin‐6 Expression in Macrophages

Interleukin 6 (IL6) is an important proinflammatory cytokine involved in the pathogenesis of many inflammatory diseases. RNA‐binding proteins, HuR and CUGBP1, regulate the mRNA stability and protein translation through direct binding to the AU‐rich domain or CUG repeats in the 3 untranslated region (3 UTR) of target genes. However, the exact role of HuR and CUGBP1 in LPS‐induced IL6 expression remains unknown. The current study examined the potential role of HuR and CUGBP1 in posttranscriptional regulation of IL6 expression during LPS‐mediated inflammatory response in macrophages.