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Fabrication of β-TCP Scaffold with Pre-Designed Internal Pore Architecture by Rapid Prototyping of Mask Projection Stereolithography

The aim of this study was to present a direct fabrication technique of β-tricalcium phosphate (β-TCP) scaffolds by a bottom-up mask projection stereolithography (MPSL) technology, which provided an excellent control of the internal pore architecture. The debinding and sintering schemes of β-TCP were determined by TG-DSC analysis, the scaffolds with designed pore architecture were obtained. The physical properties of β-TCP scaffolds were investigated including pore morphology , size and pore distribution, the crystal phase and chemical composition of sintered β-TCP were measured. Results indicated that the β-TCP scaffolds fabricated with a pore size of 0.4-0.7mm, a porosity of 58.50% and an average compressive strength of 20.92MPa met the requirements of bone scaffold. The effectiveness of degradation and cell proliferation of β-TCP scaffold were also evaluated, the results showed that β-TCP scaffolds had some certain degradability and bioactivity, which may stimulates bone tissue repair and regeneration.