{'fraction_non_alphanumeric': 0.02271714922048998, 'fraction_numerical': 0.0022271714922048997, 'mean_word_length': 5.005347593582887, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Anomalous origin of the left pulmonary artery from the internal carotid artery

We perused with great interest the fascinating images produced by Thankavel et al to illustrate their patient with tetralogy of Fallot, in whom the left pulmonary artery arises from the internal carotid artery. Their case shows the value nowadays of CT angiography in elucidating such rare patterns of arterial supply. Although their echocardiographic images are impressive, it is questionable whether the arrangement would have been fully appreciated without the clarification provided by the reconstruction of the tomographic data set. While applauding their diagnostic skills, however, we are confused by two aspects of their description. In the first place, they describe the segmental combinations in their patient in terms of {S,D,L}. To the best of our knowledge, “L” is used to account for the arrangement in which the aorta is positioned anteriorly and to the left relative to the pulmonary trunk. Their images, nonetheless, show that in their patient with tetralogy of Fallot the aorta was positioned posteriorly and to the right. How, then, do they reach the conclusion that the arterial component of the segmental set is appropriately described by “L”? More importantly, we would suggest that the left pulmonary artery is fed by much more than a persistent arterial duct. The arterial duct is derived from the left sixth arch artery, which during embryonic life extends from the aortic sac to the left-sided dorsal aorta. Part of the anomalous pathway in their patient is certainly derived from the left sixth arch artery, but much more of the original symmetrical arch arteries must have been retained if, as described, the left pulmonary artery originates from the internal carotid artery. It so happens that one of us (S.D.B.) has been working extensively with a mouse model in which there is abnormal re-moulding of the arteries coursing through the pharyngeal arches. The mouse is null for the AP2a gene. The findings illustrate perfectly the anomalous arrangement described by Thankavel et al. At embryonic day (E) 11.5, the normally developing mouse has three arteries coursing bilaterally and symmetrically through the pharyngeal arches (Fig 1).