{'fraction_non_alphanumeric': 0.020338983050847456, 'fraction_numerical': 0.0, 'mean_word_length': 6.7043478260869565, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Label‐free multiphoton microscopic imaging as a novel real‐time approach for discriminating colorectal lesions: A preliminary study

Although various endoscopic technologies have been developed to increase the visual diagnostic accuracy of colorectal precancerosis and early carcinoma, the biopsy‐dependent pathology still remains the golden standard. During routine endoscopy, real‐time optical histological diagnosis is desired. Without fluorescent label, multiphoton microscopy (MPM) imaging directly reveals live cellular morphology and tissue microenvironment based on intrinsic two‐photon excited fluorescence and second harmonic generation signals. Its high‐imaging resolution and performance are comparable with the histopathology. We thus aimed to initially investigate the original features of colorectal diseases under MPM and evaluate its potential for real‐time diagnosis.