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HLA-B60 and the HLA-B27/HLA-B60 genotype are not risk factors for acute anterior uveitis

Ankylosing spondylitis (AS) is the prototypical example of an human leukocyte antigen (HLA) -B27-associated rheumatic disease. Recently, we confirmed that HLA-B60 is also genetic risk factor for AS (OR in meta-analysis 2.2; 95% CI 1.8 to 2.8).1

Moreover, while 18% of AS patients had both HLA-B27 and HLA-B60, this combination of two HLA-alleles in one person (HLA-B27/HLA-B60) was very rare in blood donors (0.4%). As a result, individuals with the HLA-B27/HLA-B60 genotype are at a very high risk of developing AS.1 Acute anterior uveitis (AAU) may complicate AS but is also an HLA-B27-associated disease in itself.2 Given that AAU share clinical and genetic features with AS, we investigated if HLA-B60 is a risk factor for AAU.

Patients were found by retrospective review of …