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[Diagnosis and treatment of rheumatoid arthritis:toward the best practice. Statistical genetics and rheumatoid arthritis.]

Statistical genetics is a research field that assessed causality of human genome variations on phenotypes. Recent development of genome sequencing technologies provided abundant lists of causal genome variations associated with human clinical phenotypes. Integration of disease genome information with a variety of epigenetics by trans-layer omics analysis elucidated cell type specificity of the diseases, disease biology, and genome-based novel drug discovery.