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Potential Hazards of Glycerol Dialysate in Diabetic CAPD Patients

The use of glycerol-containing CAPD solutions caused some specific problems, related to the potential accumulation of the glycerol in the blood. The mean peak free glycerol levels during the exchanges with the 1.4% glycerol solution were 0.628 ± 0.079 mmol/l. With the use of the 2.5% glycerol solution, the mean peak levels increased up to 11.650 ± 2.380 mmol/1 with peak values up to 49.670 mmol/l. Sometimes, these high glycerol levels may induce a hyperosmolar syndrome, as in one of our patients. Also they cause an elevation of the blood triglyceride levels, which must be corrected for the free glycerol levels. Before we can recommend the general use of glycerol-containing CAPD solutions in diabetic patients further studies are necessary to better understand the metabolism of glycerol in uremic and diabetic patients.