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Synthesis of Novel Hydroxypropyl Methyl Cellulose Acrylate— A Novel Superdisintegrating Agent for Pharmaceutical Applications

The current study deals with the synthesis of novel hydroxypropyl methyl cellulose acrylate (HPMCAA) by the process of esterification of hydroxypropyl methyl cellulose (HPMC) and acryloyl chloride. The polymers were characterized by Fourier transform infrared (FTIR) spectrophotometry, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and hemocompatibility studies. The microstructures of the HPMC and HPMCAA powders were studied under a scanning electron microscope. The powders were used as an excipient for the preparation of lactose tablets and their composition was varied from 2 to 8% (w/w) of the total tablet weight. Disintegration studies for the tablets were carried out. The results indicated formation of a new product, HPMCAA, having properties different from HPMC. HPMCAA was found to be hemocompatible in nature. Disintegration tests indicated that HPMCAA could be tried as a superdisintegrating agent.