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Zearalenone ‐ Induced uncoupling in plant mitochondria is sensitive to 6‐ketocholestanol

Zearalenone (F‐2) is a mycotoxin which acts as a protonophoric uncoupler in plant mitochondria [Macri, F. and Vianello, A., (1990) J. Plant Physiol. 136, 754‐757]. In the present paper, the mechanism of F‐2‐induced uncoupling in pea mitochondria was studied. The uncoupling by F‐2 was partially reversed by 6‐ketocholestanol (kCh) under conditions in which kCh completely reversed the FCCP‐induced uncoupling and almost did not affect the palmitate‐induced uncoupling. Recoupling effects of carboxyatractylate, ADP and cyclosporin A were small and could not essentially decrease the kCh‐insensitive part of F‐2‐induced uncoupling. It is suggested that a protein, mediating kCh‐sensitive uncoupling, is involved in the F‐2 effect in plant mitochondria.