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Decreased Srcasm expression in hyperproliferative cutaneous lesions

Background:  Src‐family tyrosine kinases (SFKs) are signaling proteins that regulate keratinocyte proliferation and differentiation. Src‐activating and signaling molecule (Srcasm) is a recently identified molecule that downregulates SFK activity and promotes keratinocyte differentiation. To determine if Srcasm expression correlates with keratinocyte differentiation, we characterized the level of Srcasm expression in some cutaneous lesions that exhibit increased keratinocyte proliferation.