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Age of quantitative proteomics hits voltage-gated calcium channels

Voltage-gated calcium channels are complex heteromeric proteins that are involved in numerous processes, including transmitter release and muscle contraction (1, 2). They are also modulated by multiple pathways, such as those involving G proteins and Ca2+. There is thus an enormous requirement for these channels to interact with other proteins, either stoichiometrically for anchoring in the right place or transiently for signaling. Although many interactions between calcium channels and individual proteins have been found previously (3–5), the study by Muller et al. (6) in PNAS is the only one to identify, with a comprehensive and unbiased approach using affinity purification and MS, the proteome of one complete class of calcium channels, the CaV2 class (Fig. 1).