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Studies on calciferol metabolism. 3. Comparison of species distribution and chromatographic separation of vitamin D metabolites.

Abstract The majority of the radioactivity in the plasma and intestine exists as 3 polar metabolites 15 hours after the intracardiac administration of a physiologic dose (10 IU) of radioactive vitamin D 3 (cholecalciferol) to rachitic chicks. These are designated as 4A (known to be 25-hydroxycholecalciferol), 4B (known to be 1,25-hydroxycholecalciferol) and 4C on the basis of their chromatographic mobility on silicic acid columns. In the intestine, the primary metabolite is 4B; in the plasma, the predominant metabolite is 25-hydroxycholecalciferol (25-OH-CC). A detailed comparison was made of the pattern of intestinal metabolites of vitamin D 3 produced by 4 separate and different silicic acid column chromatography systems. Each Chromatographic system produced essentially identical amounts of metabolites 25-OH-CC and 4B. Additionally, the presence of metabolites 25-OH-CC and 4B, produced in vivo from vitamin D 3 , was detected in chick skeleton, laying hen uterus, and the intestinal mucosa of the chick, rat, rabbit, frog, and monkey.