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Advance in a New Binding and Inhibiting Protein Belonging to TGF-β Family:Follistatin Related-Gene(FLRG)

Follistatin related-gene (FLRG) is a glycosylated protein with rich cysteine, originally found in a B-cell leukemia line in 1998 and classified in FS family due to primary sequence being homology to FS. Its expression and regulation may be related with many systemic physiological processes. Additionally, recent research shows that FLRG is also associated with several diseases such as human endometrial cancer, insulin-resistant and metabolic syndrome. This article reviews recent advance in the discovery, denomination, structural characteristic, cell signaling, tissue distribution, mechanism, function and current research focus on the interaction among FLRG, TGF-β super-family and FS.