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Early-life Growth and Benign Breast Disease.

Body size in adolescence has been inversely associated with benign breast disease(BBD) and breast cancer risk, but little is known about the impact of growth in infancy and childhood. Using prospective data from the Early Determinants of Mammographic Density(EDMD) study (1959-2008, n=1121), we examined the associations between maternal body size, birth size and infant and early childhood growth during three time periods(0-4 months, 4-12 months, and 1-4 years) and BBD using multivariable logistic regression with generalized estimating equations. 197 women(17.6%) reported receiving a diagnosis of BBD by a physician. Higher body mass index at age 7 was inversely associated with BBD risk. Rapid weight gain from 1-4 years, defined as an increase of least two major percentiles(e.g.,5,10,25,50,75,95) relative to stable growth, defined as remaining within two percentiles, was also inversely associated with BBD (odds ratio(OR)=0.51, 95% confidence interval(CI):0.23,1.15). In contrast, rapid weight gain in infancy was positively associated with BBD relative to stable growth (OR=1.65, 95%CI:1.04,2.62 and 1.85, 95%CI:0.89,3.85, for 0-4 and 4-12 months, respectively), independent of birthweight, which was not associated with BBD. Our results suggest that patterns of early-life weight gain are important to BBD risk. Thus susceptibility to BBD, like breast cancer, may start in early life.