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[Expression of G-CSF and clinical pathological significance in cervical cancer].

OBJECTIVE
To observe the expression of granulocyte colony-stimulating factor (G-CSF) in cervical cancer and to investigate its clinical significance.


METHODS
A total of 53 cases of cervical cancer with a large number of granular cell infiltration were collected in the last ten years, and 57 cases of cervical cancer with no cell infiltration were selected as controls. The infiltration of neutrophils in cancer tissues was observed, and the expression of G-CSF in cancer tissue was detected by immunohistochemistry at the same time. And the relationship between the expression of G-CSF and clinical pathological significance in cervical cancer was analyzed. All the patients were followed up, and the effect of G-CSF on the prognosis of the patients was analyzed.


RESULTS
Expression of G-CSF was observed in 53 cases out of the 110 cases cervical cancer. Among them, 48 (90.6%) cases were squamous cell carcinoma, 5(9.4%) cases were adenocarcinoma. The expression of G-CSF was closely related to granulocyte infiltration, histological type, necrosis, high grading and regional lymph node metastasis (P<0.01), but not related to size of tumor (P>0.05). G-CSF positive cases were 33.676 and 78.495 times more dangerous than those cases that were negative in high grading and regional lymph node metastasis (P<0.01). The difference in survival between the positive and the negative was also significant (P<0.01).


CONCLUSIONS
Certain cervical cancer can produce G-CSF, and the most common in non-keratinizing squamous cell carcinoma. Cervical cancer tissue that excretes G-CSF tends to have low differentiation, obvious dysplasia, high degree of malignancy, extensive necrosis and granulocyte cell infiltration, and is often associated with lymph node metastasis, with low survival rate and poor prognosis.