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Fibrinolytic Agents in the Treatment of Necrobiosis Lipoidica

Necrobiosis lipoidica is the skin condition that characteristically affects the front of the shins in diabetics, although it may occur on any part of the body. The close association with diabetes is overtly present in at least half the cases. If the rest are stressed with corticosteroids, a third of them give abnormal responses.’ Granuloma annulare is almost certainly a variant of necrobiosis lipoidica, and there are intermediate forms in which it is difficult or impossible to differentiate between the two by either clinical or histological criteria. Again there is a relationship to diabetes in this condition, although it is not as marked as the relationship in necrobiosis lipoidica. A third of the