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Blood glucose and insulin concentration in rats subjected to physical exercise in acute poisoning with parathion-methyl.

Unexercised rats or those subjected to single physical exercise were given parathion-methyl (10 mg/kg p.o. - 0.5 DL50) or oil (vehicle). Blood glucose and serum insulin concentration were assayed 1 h after the treatment. Physical exercise depressed the serum insulin concentration without changes in blood glucose level. In acute poisoning with parathion-methyl hyperglycemia occurred concurrently with hypoinsulinemia. Physical exercise abolished the pesticide-induced hypoinsulinemia, but not hyperglycemia.