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A case of multicentric reticulohistiocytosis with multiple lytic skull lesions

Multicentric reticulohistiocytosis (MR) is a rare multisystemic disorder of unknown aetiology characterized by cutaneous and joint manifestations. It is associated with malignancy in up to 31% of cases. Common radiological findings are peri‐articular erosions and osteolytic punched‐out areas. We present a case of MR with cutaneous nodules, joint pains, and multiple lytic skull lesions − a combination that has not been described before. Osteolytic activity of proinflammatory cytokines (tumour necrosis factor‐α and interleukin‐1) may explain the peri‐articular erosions often seen in MR, and the multiple lytic skull lesions seen in our patient.