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“Haemochromatotic” characteristics of the human BEL‐7402 cell line

Hereditary haemochromatosis (HH) is an inherited disease characterized by excessive absorption and accumulation of iron in various organs (Bacon et al, 2011), and is related to mutations in the HFE, HFE2, HAMP, TFR2 and SLC40A1 genes (Pietrangelo, 2015). Mutations in HFE2 associated with HH results in reduced phosphorylation of Smad1/5/8 and hepcidin (HAMP) down-regulation (Babitt et al, 2006). As liver cells are the most affected cells in HH, immortalized liver cell lines including hepatoma cell lines are important tools to investigate the mechanism and pathogenesis of HH. Here, we showed that a widely used hepatoma cell line, BEL7402, carries a HFE2 mutation, resulting in impaired