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Review of Intravenous Selenium Infusions for the Critically III Patient

Attempts to improve mortality for patients with sepsis, severe sepsis, systemic inflammatory response syndrome, and septic shock continue to challenge health care professionals. This review will explore how the antioxidant, and possibly pro-oxidant, properties of selenium may benefit critically ill patients. Literature examining improvements in clinical outcomes from intravenous (IV) selenium infusion therapy will be discussed. Although there is not an overwhelming amount of knowledge about IV selenium and its effect on morbidity and mortality, this review will outline recent research evaluating the use of IV selenium infusions and its potential to decrease morbidity and mortality for different critically ill patient populations.