{'fraction_non_alphanumeric': 0.030035335689045935, 'fraction_numerical': 0.02561837455830389, 'mean_word_length': 4.31924882629108, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Ubiquitin A 20 maintains activation-induced CD 4 + T cell death

Aberrant T helper (Th)2 polarization plays a critical role in allergic diseases; the underlying mechanism is to be further investigated. Ubiquitin E3 ligase A20 (A20) plays an important role in the immune regulation. This study aims to test a hypothesis that A20 plays an important role in the activation-induced cell death (AICD) in CD4+ T cells. In this study, a T cell AICD cell culture model was developed. T cell apoptosis was assessed by flow cytometry used as the indicator of AICD. A food allergy (FA) mouse model was developed. The results showed that the frequency of AICD CD4+ T cells was significantly less in FA mice as compared to control mice. Much less A20 expression was detected in CD4+ T cells in FA mice than in control mice. Interaction of TIM1 (T cell immunoglobulin mucin domain-1) and TIM4 suppressed the expression of A20 in CD4+ T cells. Overexpression of A20 promoted the AICD in CD4+ T cells. In conclusion, A20 plays a critical role in the T cell AICD. To promote A20 expression can be a potential remedy in the regulation of T cell AICD.