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Influence of oral contraception on cytology and histology of the cervix uteri. Population screening for cervical carcinoma in Maribo amt 1967-1969.


 In this study women using oral contraceptives were compared with those using other contraceptive methods with regard to abnormal cytologic findings of the cervix uteri. 13,125 women were studied, of whom 1471 had used oral contraceptives for an average of 24 months. In 446 women cytologic findings were abnormal; frequency did not differ significantly betweeen users and nonusers of oral contraception. Epithelial dysplasia was found in 69 cases, carcinoma in situ in 236, invasive carcinoma in 45, trichomoniasis in 32, and simple epithelial hyperplasia in 44. No significant difference was found in any group between users and nonusers of oral contraceptives. Classifications as to age, marital status, number of pregnancies, or age at first pregnancy showed similar ratios between users and nonusers. The only variation noted was that women of the middle socioeconomic class had abnormal findings in 4.9% of users compared to 2.8% of nonusers. It was concluded that use of oral contraceptives for an average of 24 months produces no change in the frequency of any abnormal cytologic findings in the cervix uteri.
