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EDITORIAL: Recent Contributions of Medicinal Chemistry to Nano Drug Delivery Systems and Bio-Conjugates.

Aims & Scope: During the last decades delivering biologically active molecules using nano materials, have gained increasing attention in a wide range of applications from sensing and imaging to treatment of disease. The superior properties of nano materials provide numerous feasibilities such as controlling the release of drugs, targeting and imaging of cancer tumors, increasing serum half-life of bioactive molecules, passing over Blood Brain Barrier etc. and this is where, Medicinal Chemistry has a lot to say. The involvement of Medicinal Chemistry to this area, starts from the very first step of synthesis and preparation of nanocarriers in laboratory and continues till the last step, where, the newly created bioactive material will fulfill its outstanding task on biological system. The aim of this Special Issue of CTMC, is to emphasize the undeniable importance of Medicinal Chemistry in each step of the processing Nano-drug delivery systems and bio-conjugates. Nanomedicines are obtained from uploading active molecules to nano drug delivery systems. These carriers which are generally in spherical shape, are able to carry the payload either in core part or by adsorbing them to the surface. It is also possible to decorate the surface of nano drug delivery system with specialized ligands, receptors of which are over-expressed at the surface of targeted organ or tissue and cell. Bio-conjugates are synthesized by chemically binding of biologically active molecule to polymer or protein chain. Some bio-conjugates are also obtained by conjugation of proteins to polymers. Both of nano-drug delivery systems and bio-conjugates have the ability of protecting the biologically active molecule from immunologic system of body which will try to clear the body from foreigner material and consequently will increase the serum half-life of the therapeutic material. More importantly both bio-materials will provide targeting the disease side using the special properties of their own or the physiological properties of the targeted tissue.