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Haemodynamic effects of diltiazem in healthy volunteers.

While SQ 14,225 did not affect the response to 5-HT, it produced a slight but significant decrease in the response to angiotensin II, only when infused at the highest dose level. This could be related to inhibition by SQ 14,225 of the noradrenalinedependent component ofthe vascular response toAT II which is known to stimulate the release ofNA from sympathetic nerve endings (Chevillard, Duchene & Alexandre, 1971). Although our results are in favour of a specific interaction ofSQ 14,225 with the vascular reactivity to NA, more studies are needed in order to elucidate the mechanism underlying this observation. In conclusion, the present results may partly explain the preventive effect of high doses of SQ 14,225 on the development of hypertension in SHR and the hypotensive effect of a single 100 mg dose of the compound observed in anephric subjects only after substantial volume depletion, a manoeuvre which stimulates the activity of the adrenergic nervous system.