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Age‐Dependent Myocardial Sheet Dysfunction from 3 to 16 months in Duchenne Muscular Dystrophy Mice (mdx) Defined by Diffusion Tensor Magnetic Resonance Imaging (DTI)

Cardiomyocytes are organized in laminar structures (aka, sheets) that contribute to wall thickening/thinning. Diffusion tensor MRI (DTI) measures the sheet reorientation function in intact hearts. We have reported that hearts of 16‐mo old mdx mice exhibit abnormal Ca transients & Ca‐dependent sheet dysfunction at the base but not apex. Because Ca mishandling in isolated mdx cardiomyocytes is age dependent, we hypothesized that sheet dysfunction in intact mdx hearts may also be age dependent.