{'fraction_non_alphanumeric': 0.04215116279069767, 'fraction_numerical': 0.029069767441860465, 'mean_word_length': 5.6521739130434785, 'pattern_counts': {'":': 0, '<': 2, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
In Vitro Screening of Tumoricidal Properties of International Medicinal Herbs

With growing use of anticancer complementary and alternative medicines (CAMs) worldwide, there is a need to assess, screen and rank commercially available herbal products for relative tumoricidal properties under standard experimental conditions. Moreover, high through‐put screening may provide information on potentially new plant resources for chemotherapy drugs. Previously, we screened and ranked 374 herbal extracts obtained from diverse international natural plants (Phytother Res. 2009 Mar; 23(3):385–98). In the current study, we screened an additional 307 extracts predominantly from plants used in traditional Chinese medicine (0.005–5.0 mg/ml), ranking them according to tumoricidal potency on malignant neuroblastoma. The results in this study show the greatest effects (LC50 < 0.08 mg/ml) for extracts of gromwell root also known as “Hong Tiao Zi Cao” (Lithospermum erythrorhizon root) (LER) < beth root (Trillium Pendulum Root) and Galbanum (Ferula galbaniflua). The reference standard: turmeric (Curcuma longa), a known anti‐tumor herb yielded an LC50 of .269mg/ml displaying 7% the potency of LER. In conclusion, this study shows greatest efficacy for water soluble constituents within gromwell root, which is traditionally used as a Chinese tea.(Supported from NIH grant RR03020)