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Fgfs and organ regeneration in zebrafish

Appendage regeneration in salamanders and fish occurs through formation and maintenance of a mass of progenitor tissue called the blastema. A dedicated epidermis overlays the blastema and organizes its proliferation and patterning events, yet this regulation is poorly understood. Here, we dissected epidermal influences during zebrafish fin regeneration using inducible loss‐of‐function and gain‐of‐function transgenes that manipulate Fgf signaling. Our results identify positive and negative regulation that confines potent morphogenetic factors to specific epidermal territories in regenerating zebrafish fins.