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Poor sleep quality is associated with late noninvasive ventilation failure in patients with acute hypercapnic respiratory failure

crucial to minimize postoperative infections. The main objective of this large, prospective randomized trial was to determine whether preoperative skin cleansing with chlorhexidine–alcohol is more protective against infection than treatment with povidone–iodine. All patients received systemic antibiotics preoperatively. Patients (n 849) undergoing clean-contaminated surgery in six hospitals were randomized to receive preoperative skin preparation with either chlorhexidine–alcohol scrub or povidone–iodine scrub and paint. The incidence and type of surgical-site infection occurring within 30 days after surgery were recorded. The relative risk of surgical site infection among patients who received clorhexidine–alcohol scrub versus povidine–iodine was 0.59 (95% CI, 0.41–0.85).