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GROWTH HORMONE INCREASES THE LIPOLYTIC SENSITIVITY FOR CATECHOLAMINES IN HUMAN ADIPOCYTES

The lipolytic effect of growth hormone (GH) was investigated in adipocytes obtained during elective surgery from otherwise healthy adults, 18-40 years old. No lipolytic or antilipolytic effect of GH was found when the cells were incubated with GH alone during 30min-6h. When the cells were preincubated with GH during 3h, the lipolytic sensitivity for isoprenaline increased markedly without any change in maximal lipolysis. However, a full effect was only obtained if GH was also present during the incubation with isoprenaline. The effect of GH was reduced, by cycloheximide. GH did not alter DB-CAMP, enprophylline, or forskoline-induced lipolysis in human fat cells. In conclusion, GH had no direct lipolytic effect on human fat cells but GH markedly increased the catechoiamine sensitivity by a mechanism which involves protein synthesis. The site of the GH effeet seems to be in the β-adreno-ceptors or in the GH coupling protein.