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[Diagnostico-prognostic significance of the analysis of anti-HIV antibodies and viral antigens in acquired immunodeficiency syndrome. Presentation of 2 paradigmatic cases].

The authors, after reviewing the current literature about the serological pattern of anti-HIV antibodies detected with Western Blot and the research of the viral antigen in AIDS, report the study of the above mentioned parameters in two HIV seropositive drug addicts. Case 1 (symptomless seropositive) presented a reactivity against p24 and p55 a month after an acute HIV infection and a more delayed reactivity to the whole anti-HIV antibody pattern. Case 2 (which developed full-blown AIDS), together with clinical and immunological deterioration, had a decline and disappearance of antibodies to p24 and persistence of reactivity against gp41 and detection of viral antigen. Diagnostic and prognostic significance of these results are discussed.