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Hypomorphic mutation in the hairless gene accelerates pruritic atopic skin caused by feeding a special diet to mice

increased amounts of the antioxidants Ucp2, Gpx1 and Sod1 compared to the other regions. As the amount of sebocytes was controlled for by the use of Fabp4, the increased antioxidant expression in the tip may be due to differences within the hair cycle or for protection from external damage and renders further investigation. Despite this, the lack of a difference in the thermogenic UCP1 protein and RNA within the regions indicates that UCP1 within the sebocyte population is irresponsive to regional temperature variations in the tail. Lastly, because the amount of BAT and UCP1 activity is greatly reduced or even lost during ageing (5) and this same ageing pattern could be recapitulated in tail, Ucp1 expression and protein localization were compared in tails among young (3 months old) and aged (12 months old) mice. Age had no effect on the expression of the well-characterized thermogenic genes Ucp1 or Prdm16 between mice (Figure S3a). In addition, neither the immunofluorescence intensity nor the location of UCP1 protein differed notably in the terminal tail region between young and aged mice (Figure S3b). Conclusions We extended the results by Mori et al. (6) showing that Ucp1 is expressed in various locations in the tail sebaceous glands. Our data, however, do not indicate that the role of sebaceous gland UCP1 is one of thermoregulation. Further, we provide evidence that UCPs in the sebaceous gland serve an alternative antioxidant role as described in other organs (8). Acknowledgements Miller performed the research, designed the study, analysed the data and wrote the manuscript. Yu, Amabti, McKinney and Avra performed the research and analysed associated data. Baile and Meagher participated in the study design and contributed essential reagents and equipment. All of the present authors participated in the drafting and revision of the manuscript and have approved all versions of the manuscript and its associated documents prior to submission. This research was supported by the Atlanta Chapter of the Achievement Awards for College Scientists (CNM) and by the National Institute of Diabetes and Digestive and Kidney Diseases (#DK090300) (RBM). Additional support was provided from the Georgia Research Alliance Eminent Scholar Fund and the UGA Research Foundation (CAB). Conflict of interests The authors declare no conflicting interests. Supporting Information