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Gastro-oesophageal reflux – an increasing burden

In addition to the impact of GORD on daily life and socioeconomic factors (e.g. medical costs), there is increasing scientific evidence of a strong correlation between GORD and a distinctive change to the histological pattern seen in oesophageal carcinoma, which shows a marked shift from squamous cell cancer in the mid and upper oesophagos to adenocarcinoma in the distal oesophagus and gastro-oesophageal junction.