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[Robotic mechanotherapy in patients with multiple sclerosis with impaired walking function].

OBJECTIVE
To study an effect of robotic mechanotherapy on the functional condition of patients with multiple sclerosis (MS) with impaired walking function using the ExoAtlet exoskeleton.


MATERIALS AND METHODS
A prospective open-source, uncontrolled, single-center study included 44 patients (main group, MG) with remitting course in remission (RRS) and secondary-progressive course (VPRS) of MS with 3 to 8 points on the Extended Disability Status Scale (EDSS). Eighteen people (subgroup 1) of this group were re-examined after 3 months and 8 people completed the second rehabilitation course (subgroup 2). Neurological deficits and functional condition of patients were assessed using the EDSS, the Multiple sclerosis functional composite (MSFC) test, which includes the assessment of walking - Timed 25- Footwalk, the assessment of upper limb functions - 9-HolePegTest (9-HPT), the assessment of mental abilities - Symbol Digit Modalities Test (SDMT). Additionally, cognitive functions were assessed by the Montreal Cognitive Assessment Scale (MoCA).


RESULTS
The improvement in the EDSS score was 0.23 points (5%, p<0.001) after the first course and 0.64 points (12%, p<0.02) after 3 months. The study of the pyramid system showed an improvement of this indicator by 0.29 points (10.2%, p<0.02) in patients of MG and by 1 point (32.3%, p<0.05) in subgroup 2. The SDMT subtest showed the improvement by 2.3 points (4.5%, p<0.02) in MG. In subgroup 2, the improvement by 17.1 points (38.9%), p<0.05) before the start of the 2nd course and by 22.9 points (52%, p<0.02) at the end of the 2nd course of rehabilitation was observed. The improvement of the Timed 25-Foot walk test in MG patients was 3.1 seconds (19.6%, p<0.001), the 9-Hole Peg Test on the dominant hand was 1.56 seconds (5.1%, p<0.02), and on the non - dominant hand 2.28 seconds (6.2%, p<0.02). After rehabilitation, the MoCA test showed the significant (p<0.001) improvement in cognitive functions by 1.6 points (6.1%) in MG and by 1.9 points (7.5%, p<0.05) in subgroup 2.


CONCLUSION
The results have shown the effectiveness regarding the problems in MS patients and the prospects for further study of the possibilities of robotic assistance to walking and support a vertical posture using the ExoAtlet exoskeleton in order to restore walking function in MS patients with motor deficits.