{'fraction_non_alphanumeric': 0.019348749410099102, 'fraction_numerical': 0.002831524303916942, 'mean_word_length': 5.404833836858006, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Oral reactions to sublingual immunotherapy: a bioptic study

glucocorticosteroids without the necessity for hospitalization. After resolution, the oral challenge test with a cephalosporin was well tolerated. Another amoxicillin patch test positive patient tolerated the oral challenge with penicillin, thereby revealing an isolated allergy to amoxicillin. As a challenge test would involve the risk for the patients to experience the same signs and symptoms of the previous drug reaction, the decision of four out of eight patients not to perform an oral challenge test was respected. Two of three patients, who were completely negative in the allergy diagnostic tests, agreed to an oral challenge with verum and revealed tolerance to the drug. It can be hypothesized that the third patch test negative subject may also have tolerated amoxicillin challenge. These three individuals may belong to the population, which only has a transient decrease in drug tolerance during EBV infection. Two amoxicillin patch test positive patients could be examined in a follow-up visit 2.2 and 1.5 years, respectively, after the first patch testing. Those patients revealed a patch test reaction similar in strength to the preliminary test result, which is indicative for a persistent delayed-type reaction to amoxicillin. In conclusion, this study does not only provide additional evidence that true delayed-type allergic reactions to aminopenicillins may develop during a florid viral infection, but that they may be definitely more prevalent than previously assumed and published (5, 6). Additionally, follow-up investigations on two patients revealed the persistence of the delayed-type reactions to amoxicillin, an approach, which has to the best of our knowledge not been published before. These observations should encourage the investigation of patients with aminopenicillin-induced exanthema for both, EBV-infection and true drug allergy. Particularly young women should be recommended an oral challenge with cephalosporins and maybe penicillins because the latter are antibiotics which may be given safely during pregnancy.