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Statistical Significance versus Clinical Importance

Conventionally, P < 0.05 has been termed “statistically significant,” but often what is statistically significant is not always clinically important, and what is statistically nonsignificant may be a case of an unwarranted claim of “no difference.” Similarly, if a study is conducted to check replicability of the previously published results of a study, reliance on P-value may lead to unwarranted claims of refutation or unwarranted denial of refutation. These are some of the reasons why several experts have risen against statistical significance.[1,2] However, others have supported retaining P-value but at a more stringent level of significance say P < 0.005.[3,4]