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Cell Culture in Parallel Integrated Bioreactor Arrays

Overview The research in the Physical Optics and Electronics Group is divided along three primary themes: • Integrated Photonics • Biophotonics and Bioprocessors • Thermodynamics of Semiconductor Devices In all three areas the goal of this research is to exploit processes in physics to invent new devices that lead to better systems. Each researcher works to model and design a new device, implement the design, and then integrated this device into a system which defines the state-of-the-art. The major achievements of the laboratory during the last year were: The demonstration 1. Fabrication of zero-birefringence InP waveguides with large Faraday rotation. 2. Spatially resolved measurements of perimeter degradation in Ge-on-Si detectors. 3. Design of record low-power tunable microring filter in SiN. 4. Demonstration of 3-D polymer waveguide circuits. The waveguides were used to illustrate frequency-domain multiplexing of a sensor array. 5. Demonstration of a microfluidic mixer with shear control enabling the culture of mammalian cells (Chinese Hamster Ovary cells). 6. Completion of a technology needs-assessment for the biopharmaceutical industry. 7. Design of high power thermoelectric generator employing microchannel cooling.