{'fraction_non_alphanumeric': 0.04975348934101798, 'fraction_numerical': 0.03923338657037706, 'mean_word_length': 4.5754936120789775, 'pattern_counts': {'":': 0, '<': 26, '<?xml version=': 0, '>': 5, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 6, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Human health risk assessment of PM2.5-bound heavy metal of anthropogenic sources in the Khon Kaen Province of Northeast Thailand

The study aimed to assess the human health risk of PM2.5-bound heavy metals from anthropogenic sources in Khon Kaen Province, Thailand between December 2020 and February 2021. According to the findings, the geometric mean concentration of PM2.5 in the university area, residential area, industrial zone, and the agricultural zone was 32.78 μg/m3, 50.25 μg/m3, 44.48 μg/m3, and 29.53 μg/m3, respectively. The results showed that the estimated human health risk assessment, in terms of non-carcinogenic risks among children and adults in an urban area (residential and university), industrial zone, and the agricultural area, was of hazard index (HI) value of >1.0 indicating a greater chance of chronic effects occurring. This study showed that exposure to PM2.5-bound heavy metal may increase the likelihood that lasting effects will result in a very high carcinogenic risk (CR) in children in residential areas, and an industrial zone with total carcinogenic risk (TCR) values of 0.23×101, and 0.12×101, respectively while resulting in a high TCR of 3.34×10−2 and 4.11×10−2 within the university areas and agricultural zone, respectively. In addition, health risk assessments among adults demonstrate high TCR values of 4.40×10−1 (residential area), 2.28×10−1 (industrial zone), and 7.70×10−3 (agricultural zone), thus indicating a potential health risk to adults living in these areas while the university area was very low effects on carcinogenic risk (CR≤10−8) for adults. Therefore, lowering the risk of exposure to PM2.5 via the respiratory tract, for example, wearing a mask outside is a very effective self-defense strategy for people within and around the study site. This data study strongly supports the implementation of the air pollutant emission source reduction measures control and health surveillance.

The study aimed to assess the human health risk of PM 2.5 -bound heavy metals from anthropogenic sources in Khon Kaen Province, Thailand between December 2020 and February 2021. According to the findings, the geometric mean concentration of PM 2.5 in the university area, residential area, industrial zone, and the agricultural zone was 32.78 μg/m 3 , 50.25 μg/m 3 , 44.48 μg/m 3 , and 29.53 μg/m 3 , respectively. The results showed that the estimated human health risk assessment, in terms of non-carcinogenic risks among children and adults in an urban area (residential and university), industrial zone, and the agricultural area, was of hazard index (HI) value of >1.0 indicating a greater chance of chronic effects occurring. This study showed that exposure to PM 2.5 -bound heavy metal may increase the likelihood that lasting effects will result in a very high carcinogenic risk (CR) in children in residential areas, and an industrial zone with total carcinogenic risk (TCR) values of 0.23 × 10 1 , and 0.12 × 10 1 , respectively while resulting in a high TCR of 3.34 × 10 −2 and 4.11 × 10 −2 within the university areas and agricultural zone, respectively. In addition, health risk assessments among adults demonstrate high TCR values of 4.40 × 10 −1 (residential area), 2.28 × 10 −1 (industrial zone), and 7.70 × 10 −3 (agricultural zone), thus indicating a potential health risk to adults living in these areas while the university area was very low effects on carcinogenic risk (CR ≤ 10 −8 ) for adults. Therefore, lowering the risk of exposure to PM 2.5 via the respiratory tract, for example, wearing a mask outside is a very effective self-defense strategy for people within and around the study site. This data study strongly supports the implementation of the air pollutant emission source reduction measures control and health surveillance.

Introduction
Air pollution is one of the most serious environmental problems to be addressed locally, regionally, and globally. It is endangering human health and life, as well as having a variety of indirect effects on society and the economy, such as weakening a country's economic growth potential by reducing people's working hours and lowering agricultural production (Narita et al., 2019). In 2017, Exposure to PM 2.5 resulted in 4.58 million deaths and 142.52 million years of disability worldwide, with ambient PM 2.5 accounting for 64.2 percent of fatalities and 58.3 percent of disability-adjusted life years (Bu et al., 2021). Chronic exposure to PM 2.5 has been linked to respiratory diseases, heart disease, stroke, brain, and lung cancer (Cao et al., 2011;Du et al., 2015;Fold et al., 2020;Sakunkoo et al., 2022;Pope Iii et al., 2002). PM 10 and PM 2.5 majority include road traffic, biomass and waste open burning and industrial area (Fang et al., 2013;Li et al., 2021a;Tobler et al., 2020;Wang et al., 2020), construction of buildings and demolition (Yan et al., 2019), crop residue burning (Yang et al., 2008), and informal electricwaste recycling site (Zheng et al., 2016). PM contains a mixture of a chemical component, which can be produced from primary sources or formed by complex atmospheric reactions. . PM 2.5 during 2016-2019 in Bangkok, 24-h Thailand Ambient Air Quality Standards (TNAAQs) a dose of 50 μg/m 3 was exceeded for about 50 days/years and a maximum daily concentration of more than 100 μg/m 3 was observed during the dry season. (November to April) (Fold et al., 2020). Previous conducted study PM episode, Ji County in Tianjin, China by Zhou et al. (2015) has reported health impact with a relative risk (RR) were 1.013 (CI 1.0074-1.019) for all-cause mortality per 10 μg/m 3 increase in PM 2.5 . Therefore, chronic exposure to PM 2.5 is known to produce excessive exposure to the alveolar angiotensinconverting enzyme 2 (ACE-2) receptor, which may promote infection or toxicity in those exposed to air pollution (Domingo et al., 2020), especially, as long-term exposure to ambient PM 2.5 is linked to increased morbidity and premature death in epidemiological studies (Pope and Dockery, 2006;Tobler et al., 2020;Zhu et al., 2019). Dockery and Pope (1994) reported that the increase in mortality and morbidity in urban areas may be associated with exposure to particulate matter (PM). The potential for adverse health effects from PM varies in particle size, composition, toxicity, and degree of exposure. In addition, the hospitalization rate for chronic obstructive pulmonary disease (COPD) increased by 6.88%, and the total number of hospital, patient, and asthma emergency rooms increased by 0.67%, 0.65%, and 0.49%, respectively of 10 μg/m 3 for PM 2.5 concentration (Duan et al., 2020;Xie et al., 2019).
Furthermore, the chemical compositions of PM 2.5 include organic matter, trace elements, water-soluble inorganic ions, inorganic substance, sulfate, nitrate, and polycyclic aromatic hydrocarbons (PAHs) and others Cheng et al., 2015;Fan et al., 2021;Jiang et al., 2018;Sajjadi et al., 2018;Zhang et al., 2021). In particular, a small fraction of particulate matter with aerodynamic equivalent diameter ≤2.5 μm constitutes heavy metals, and is highly toxic even at low concentrations, levels such as Cr, Cd, As, Pb, and Ni (Baensch-Baltruschat et al., 2020;Nirmalkar et al., 2021). A recent study has exhibited that heavy metals attached in PM 2.5 , such as Pb, Cu, Ni, and Fe collected from high-traffic regions, have been shown in recent study to be capable of triggering a variety of respiratory and cardiovascular illnesses, even a low concentration level of metals in PM 2.5 can be harmful to human health (Kastury et al., 2018;Moryani et al., 2020). Metal elements from natural sources such as soils/crustaceans are usually found in coarse particles, while fine particles are associated with anthropogenic sources (Ny and Lee, 2011;Shaltout et al., 2019). Heavy metals can distribute and accumulated in the environmental cycle, for example, surface soil (Han et al., 2021), groundwater (Varol and Tokatlı, 2022) and atmosphere (Li et al., 2021b;Moryani et al., 2020;Pongpiachan et al., 2017;Wu et al., 2019;Xu et al., 2020;Zheng et al., 2016;Zhi et al., 2021). Previous studies shown a linkage between PM 2.5 exposure and toxic heavy metal components having negative adverse health effects (Liu et al., 2018;Zhang et al., 2015). Currently, several toxicological studies have pointed out that excessive exposure to heavy metals in PM 2.5 could threaten on human health, causing respiratory and inflammation of lung, cardiovascular disease, heart disease, and cancer (Xie et al., 2020;Xu et al., 2020;Zhang et al., 2021), specially, the heavy metals and organic pollutants adsorbed by PM 2.5 were risk factors for lung cancer (Duan et al., 2020). Oral ingestion, inhalation, and dermal contact are the main routes of exposure to airborne heavy metals in PM 2.5 (Hu et al., 2012;MohseniBandpi et al., 2018;Wang et al., 2020;Zhang et al., 2021), and are they are easily absorbed by the human body's alveolar, blood, cutaneous, and gastrointestinal systems (Cao et al., 2012;Imani, 2021). Undoubtedly, the study results show the possibility that adverse health effects are associated with particulate matter exposure bound to toxic heavy metals. To date, the chemical characterization, human health risk assessment, and source apportionment of PM 2.5 -bound heavy metals have been widely studied Li et al., 2021b;Zhang et al., 2021).
Data from the Pollution Control Department (PCD) air quality monitoring system showed that the provinces with the most frequent detections of air quality exceeding the standard more than 70 days per year such as Saraburi, Lampang, Khon Kaen, Phrae, Phayao, Nan, Chiang Mai, Chiang Rai, Tak and Mae Hong Son (PCD, 2020). Khon Kaen Province is one of the agriculture, urban and industrial areas that have been rapidly growing in Northeast Thailand due to urban development; rapid industrial economy expansion has resulted in the continued increase of many transport systems to meet human needs. This information, is therefore, an important highlight the researcher to choose to study in such areas. While studies on heavy metal concentrations in PM 2.5 in Thailand have been conducted in the past, they have been limited due to scarce data, especially on the country's regional aspect. Understanding the levels of particulate matter in the air have important public health consequences considering the increasing trend of air pollution. Hence, this study aims to examine the human health risk assessment of PM 2.5 -bound heavy metal of anthropogenic sources in Khon Kaen Province of Northeast Thailand. The data of this study will help support policies and future control measures in reducing pollutant emission from anthropogenic activities while also communicating health risks and surveillance to develop a further plan in the short and long-term to minimize adverse effects on human health.

Study area
Due to the topography of Khon Kaen Province (KKP), most of the plateaus and low mountains; the weather is quite hot in the summer and the weather is quite cold in winter. The average temperature throughout the year is about 26.9 • C and the average annual rainfall 1,246.8 mm. The KKP covers an area of approximately 10,885.9 km 2 and is approximately 449 km from Bangkok. Therefore, sampling site is in Khon Kaen Province, one of the largest urban development, agricultural activities, and industries in the north-eastern part. In this study, the following locations for ambient air samples were collected: The study site in Muang Khon Kaen is 16 • 26 ′ north latitude and 102 • 50 ′ east longitude (166 m above of mean sea level) is represented by urban area (includes university, and residential), and industrial zone and covering an area of 953.4 km 2 and agricultural areas in Ban Haet District (BHD) and covering an area of 205.2 km 2 . The location of BHD is 16 • 12 ′ north latitude and 102 • 45 ′ east longitude at 189 m above of mean sea level (Fig. 1). The pattern of land use in KKP has shifted drastically over the past few decades. The Thai Meteorological Department (TMD, 2015(TMD, , 2020 has divided the climate into three seasons: local summer (mid-February to mid-May), the rainy season (mid-May to mid-October), and the winter season (mid-October to mid-February). The KKP is the country's largest urban development region and the industry has accelerated environmental concerns. This is because the region is facing air pollution issue for nowadays; in particular, Khon Kaen is one of the provinces in north-eastern, Thailand faces a high level of seasonal air pollution every year. The community dwellers are exposed to outdoor air pollutants 24 h a day during seasonal smog periods because of their open-air housing style, and agricultural occupational hazards.

Sampling collection and analysis
The PM 2.5 samples were collected from ambient 24 h air sample collection during December 2020 and February 2021 period (dry season) using a high-volume air sampler (model ECO-HVS3000, Ecotech, Australia) was used with a flow rate of 67.8 m 3 /h, at 1.50 m above ground level. After sampling, each glass fiber (GF) filter was used to adjust the filter paper before and after collecting samples by putting it in a desiccator not less than 24 h. Inside the desiccator, silica gel was placed at the bottom. These samples are then stored in the refrigerator at a temperature of −30 • C. During the previous treatment procedures, each load filter was cut and placed in a Teflon vessel, and 5 mL of HNO 3 , 2 mL of HF, and 1 mL of H 2 O 2 were added; later, the collected PM 2.5 was wet and digested by ultrasonic-assisted digested (model TRANSSONIC 700/H). After cooling, these solutions were diluted to 5 mL with 5% HNO 3 for use in subsequent metal analysis. In this study, seven trace elements (Pb, Cu, Cd, Fe, Mn, Al, and Zn) were measured by Graphite furnace atomic absorption spectroscopy (GFAAS) (model PinAAcle900Z, Perkin Elmer). PM 2.5 sampling and analysis methods, as well as quality assurance and quality control measures, were in line with the PM 2.5 component manual established by Chow et al. (1998) and Sugita et al. (2019).

Enrichment factor (EF)
Enrichment factor (EF) was used to assess the level of heavy metal contamination in atmospheric particles and method facilitated the sep-aration of heavy metal contribution between natural and anthropogenic origin. The EF by Zhang et al. (2021) where calculation is expressed as follows: crust denote the concentration levels of metal and the iron metal in the sample and crust. Fe was selected as the most common reference in this study (Pongpiachan et al., 2017) and the abundance of the elements' concentration of seven metals in the continental crust (in mg/kg) were obtained from (Lide, 2004). EF values are classified into five levels based on the influence of human activities (Yongming et al., 2006), were not influenced by human activities (EF < 2), moderately influenced (EF 2-5), highly influenced (EF 5-20), highly influenced (EF 20-40), and were severely influenced (EF > 40), respectively.

Geo-accumulation index ( geo )
The geo-accumulation index ( geo ) was used to assess the level of heavy metal contamination by comparing the current concentration with rear levels. The calculation of geo index was done by where sample and crust represent the concentrated level of the metal in the sample and background, respectively. The factor of 1.5 was applied as a background adjustment matrix for evolutionary and anthropogenic effects (Li et al., 2015). In this study the geological heavy metal deposition index. The geo-accumulation index; Igeo was classified into six levels of contamination according to the study guideline of Murari et al. (2020): Level 1: ≤ 0 (Uncontaminated), Level 2: 0-1 (Uncontaminated to Moderately contaminated), Level 3: 1-2 (Moderately contaminated), Level 3: 2-3 (Moderately to strongly contaminated), Level 4: 3-4 (Strongly contaminated), Level 5: 4-5 (Strongly to extremely contaminated), and Level 6: > 5 (Extremely contaminated), respectively.

Human health risk assessment (HHRAs)
The subjects were divided into two groups viz., Children and Adults based on the differences in their respiratory systems and behaviors. (Dahmardeh Behrooz et al., 2021;Hu et al., 2012). Exposure assessment is a measurement process and refers to the time when people are exposed to substances in the environment or future exposure forecast. The values used for all the parameters in health risk assessment (HRA) as illustrated in Table 1.
Thus, the daily intake of the chemical through oral ingestion (CDI ing , mg/kg/day, exposure concentration through inhalation (EC inh , μg/m 3 ), and skin absorption dose through dermal contact (DAD der , mg/kg/day) by Zhang et al., 2021 andUSEPA, 2014 were calculated using the Eqs.

Mass concentration of PM 2.5 in the typical anthropogenic sources
In this study, PM 2.5 sampling was done during the dry season to analyze the heavy metal composition of PM 2.5 in four human activities areas: University area, residential area, industrial zone, and agricultural zone found that in all sampling areas, the concentration of PM 2.5 in the atmosphere exceeds the standards set by the World Health Organization (WHO) (WHO, 2006), which must not exceed 25 μg/m 3 and Pollution Control Department (PCD) of Thailand 50 μg/m 3 for 24 h (PCD, 2020), respectively. The areas with the geometric mean concentration (μg/m 3 , 95% CI) of PM 2.5 were residential area at 50.25 μg/m 3 (95%CI 38.97-64.78), followed by industrial zone, university area, and agriculture zone at 44.48 μg/m 3 (95%CI 35.06-56.42), 32.78 μg/m 3 (95%CI 26.56-40.46), and 29.53 μg/m 3 (95%CI 23.62-36.91), respectively, as shown in Table 2. A majority of emissions were from automobiles at traffic sights with 32% and burning of biomass with 26% (Chuersuwan et al., 2008). Biomass burning emerged as the primary source of PM 2.5 mass concentrations at residential sites, for example, an issue of crossborder smog due to sampling periods (Chuersuwan et al., 2008). It is in the dry season and is influenced by the northeast monsoon that blows dust from neighboring areas and neighboring countries and meteorological factors. The mean concentration of PM 2.5 of all sampling sites that exceeded the WHO (2006), which must not exceed 25 μg/m 3 . While three of the four sampling sites that mean concentration were below the Pollution Control Department (PCD) of Thailand 50 μg/m 3 for 24 h, while PM 2.5 concentrations in a residential area are above the PCD standard setting of Thailand.
The majority of PM 2.5 sources in Southeast Asia come from vehicular emissions, industrial pollution, and secondary aerosols as the dominating sources (Singh et al., 2017). Vehicular activities, industrial by-products, and re-suspension of crustal soil are the major factors contributed by anthropogenic activities of the emission of particulate pollutants within the environment (Hazarika and Srivastava, 2017a;Hazarika et al., 2017b;Tian et al., 2010). Additionally, Northeast Thailand is an important region for sugarcane and rice production. Due to insufficient mechanical support, approximately 60% of the crops have  to be burned before harvesting (Dejchanchaiwong et al., 2020). Yunesian et al. (2019) conducted a study in PM 2.5 and PM 10 in the metropolis of Tehran during 2016-2017, which was reportedly exposed to high levels and the associated health risks. Similarly, a study conducted in Chiang Mai, Northern Thailand has reported that the rate of chronic obstructive pulmonary disease increased by 7.2-8.9%, coronary artery disease by 8.6%, and sepsis specific causes of death were increased by 5.7-6.1%, for 10 μg/m 3 increment of PM 2.5 (Pothirat et al., 2021).

Heavy metals concentration in PM 2.5
As shown in Table 3, sorted from the areas with the highest concentration of PM 2.5 found that an industrial zone with heavy metal concentrations in PM 2.5 in descending proportion are as follows: manganese (Mn) < aluminum (Al) < lead (Pb) < copper (Cu) < cadmium (Cd) < iron (Fe) < Zinc (Zn), residential area (Al < Mn < Pb < Cu < Cd < Fe < Zn), university area (Mn < Al < Pb < Cu < Cd < Fe < Zn), and agricultural area (Mn < Al < Cu < Pb < Fe < (Cd = Zn), as shown in Table 3.
Pb, Cd, Mn, and Cu were found to be the most relevant trace metals in the period study and it has been sufficiently recognized that they are traced in traffic emissions (Rodríguez et al., 2020;Zhang et al., 2009); Mn is identified as tracers of dust or soil. The proportion of heavy metals in PM 2.5 each human activities as shown in Fig. 2. Rodríguez et al. (2020) described the origin of the measured metals as practical, from human-caused sources such as traffic emissions, fuel oil combustion, or even re-suspended particulate matter and dust storms events (Amarloei et al., 2020). For instance, some major elements connected with PM 2.5 measured in this study (Pb, Cd, Cu, or Mn), are found to be emissions from debris of wearing of tyres and old's automobile combustion systems (Adachi and Tainosho, 2004). Additionally, Kayee et al. (2020) has showed that an important source of Pb and other trace metals in the Chiang Rai aerosol in Northern Thailand were metals that were released from burning of biomass and the crustal dust formed from raging fire. Based on these comparisons, it may be decided that the PM 2.5 concentrations of metals primarily depend on the topology, meteorological factors such as wind speed, pressure, and the sampling site, which, consecutively, relies on the effects of sources of metal emissions nearby power plant, traffic transportation, and biomass and waste open burning. This study would help improve our understanding of anthropogenic activities over Khon Kaen and the significance of linking such atmospheric studies with meteorological parameters.

Environmental risk
Comprehensive anthropogenic metal risk assessments can provide valuable information for risk management at sampling sites, which are less valuable for natural-sourced metals. Fig. 3 shows a Pb, Cd, Cu, and Mn being identified as human-caused metals with an EF greater than 10 (Fig. 3a), while an Igeo greater than 0 was found only with Cd as shown in Fig. 3(b) as shown in Fig. 3.
A study conducted by Wu et al. (2019) found that augmented factors of heavy metals (Cd and Pb) in PM 2.5 were mainly from anthropogenic sources. Therefore, the variation of EF source contributions should be influenced by meteorological factors and environmental conditions . Furthermore, agricultural emissions of Cd and Pb in the ago-ecosystem have been shown to have a source harmful impact and can cause various long-term health issues (Pongpiachan et al., 2017). Thus, the following analysis of the human health risk as-sessment focuses mainly on the four metals. The findings of this study are based on the comparison of emissions from sources of human activities. However, the most important control measures must be taken into consideration, especially the air quality in which people live in the sampling area or nearby.

Human health risk assessment of heavy metal's exposure in PM 2.5
Heavy metals are considered pollutants to humans as well as the environment. Therefore, this study also focuses on two heavy metals (Cd and Pb) has been proven to be hazardous to human health (Briffa et al., 2020;Tchounwou et al., 2012). Considering that Cd is classified as a Group 1 (carcinogenic), while Pb is classified as a Group 2A (probably carcinogenic). The health risk values are overestimated as the health risk assessment was conducted using total heavy metal concentration. The appropriate heavy metal form to be used is the bioavailability form to be applied in HRA (Praveena et al., 2015;Zheng et al., 2020). Hence, these heavy metal data were used for the carcinogenic risk assessments among humans as shown in detail below

Non-carcinogenic risks
The risk to human health in the urban area (residential and university), industrial zone, and agricultural zone of Khon Kaen Province, Northeast Thailand through various ways of exposure merits investigations and surveillance. Furthermore, Table 4 illustrates the six anthropogenic metals that cause health risks in children and adults. The following order was used: Pb, Cd, Cu, Mn, Zn, and Al, to study contributions in urban areas (university, and residential), and industrial zone and agricultural zone with the total HI value of >1.0 for these four sampling sites which demonstrated the total non-carcinogenic risk exceeded the safe level revealed, the potential health risk is quite high for Cd and Pb that the integrated effects of multi-metal exposure in the urban area (university, and residential), industrial, and agricultural of sampling sites, might result in severe non-carcinogenic risk. The results of this study found that HI was at a level that was at risk for chronic health effects. In line with the findings of Pongpiachan et al. (2017), metal studies in PM 2.5 in Bangkok from 17 November to 30 April 2011 found that the HI values of Cu, Zn, Cd, and Pb were at safe levels. Corresponding to the study, PM 2.5 -bound heavy metal in the urban area of Kitayushu, Japan reported the total of heavy metals with a corresponding HI of 7.8 and mainly comprising ingestion exposure pathways followed by dermal contact, and inhalation for adults and among children, the route of entry into the body is through ingestion, inhalation, and dermal contact . As per this study, HI ing , HI inh , and HI der , indicated that the primary source of exposure was inhalation, followed by ingestion and contact through skin. In addition, researchers discovered that exposure to urban traffic-related air pollution had genotoxic effects on children in Malaysia's Klang Valley (Hisamuddin et al., 2020). Therefore, it is important to put in place a long-term plan to reduce the levels of Cd and Pb in urban dust, by promoting the use of electric vehicles, cycles and encouraging citizens to use public transportation (Pongpiachan et al., 2017), and conducting further research  on the sources of air pollution and steps to control air pollution, such as open burning and waste incineration facilities.

Carcinogenic risks
In addition, Pb and Cd were carcinogens among two heavy metals. The CR values of Pb among children in university, residential, industrial, and agricultural were 1.00 × 10 −8 , 1.71 × 10 −8 , 2.22 × 10 −6 , and 1.95 × 10 −7 , respectively, and Cd where the CR values were 3.34 × 10 −2 , 0.23 × 10 1 , 0.12 × 10 1 , and 4.11 × 10 −2 , respectively. In this study, the risk of above the safe level i.e. ≥ 10 −1 , revealed a high level of carcinogenic risk for children living in the urban area (residential) and industrial zone while the results that high carcinogenic risk (10 −3 ≤ CR < 10 −1 ) (Roy et al., 2019;Zhang et al., 2021) for the urban area (university) and agricultural area. As compared with adults, the CR values of Pb among children in university, residential, industrial, and agricultural were 4.00 × 10 −9 , 5.00 × 10 −7 , 6.48 × 10 −7 , and 5.70 × 10 −8 , respectively, and Cd where the CR values were 8.10 × 10 −8 , 4.40 × 10 −1 , 2.28 × 10 −1 , and 7.70 × 10 −3 , respectively. However, the risk level in this study above the safe level 10 −3 ≤ CR < 10 −1 , revealed a higher risk of carcinogenic for adults living in urban areas (residential and industrial), and agricultural zone exempt in university area the results that very low carcinogenic risk (CR ≤ 10 −6 ) (Roy et al., 2019;Zhang et al., 2021). In total, the combined carcinogenic risk for children and adults' (university, residential, industrial, and agricultural) was also above the acceptable limits, it was found that the Cd of carcinogenic risk obtained was high than the ceiling value of 10 −6 , which is significant based on the USEPA standards; it becomes evident to conclude that Cd increases the lifetime cancer risk; except for adults living in university areas, the levels were very low for carcinogenic risk. In addition, they comprise the majority of exposure dose assessments among children and adults were CR ing , CR der , and CR ing ( Table 5). Based on the results of the health risk assessment, it is evident that in the urban area (such as university, residential), industrial zone, and rural agricultural of Khon Kaen Province, Thailand, exposure to PM 2.5 could significantly influence the environmental risks. Furthermore, children's health is at higher non-carcinogenic and carcinogenic risk than adults. Additionally, Pb, Cd, Cu, Mn, Zn, and Al were found to be in abundance. As a result, when PM 2.5 -bound heavy metals are introduced into the body, particularly through the respiratory system, they encourage and induce health problems.