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Paget’s disease of the breast after nipple-areola sparing mastectomy: case report

Paget’s disease of the breast is a rare condition. It accounts for 0.5-5.0% of all breast carcinomas [1, 2]. It is generally associated with underlying ductal in situ or invasive carcinoma [3]. Clinically, Paget’s disease of the breast manifests as a pigmented, eczematoid lesion, with erythematous eruptions or a scaly lesion with irregular borders located in the nipple-areola complex. It is usually limited to the nipple or extended to the areola. In advanced cases, it may involve the surrounding skin [4]. Paget’s disease may be primary or present as a local recurrence after previous breast cancer treatment [5-9]. Local recurrence occurs in 2.2-13.3% after breast-conserving treatment [7-11]. The incidence of tumor recurrence after nipple-areola sparing mastectomy is still unknown [12]. The cause of Paget’s disease presenting as a local recurrence remains unknown. The epidermotropic and transformation theories have been proposed to explain the pathogenesis of the disease. The authors report a case of Paget’s disease occurring after nipple-areola sparing mastectomy.