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Spiny mouse is protected from ischemia induced cardiac injury: leading role of microRNAs

Despite advances in drug therapy, revascularization and surgical interventions, mortality and morbidity from heart failure in ischemic heart disease remains high and a breakthrough in our understanding of this disorder is needed. Spiny mouse (Acomys cahirinus) has evolved a remarkable capacity to regenerate full thickness skin tissue without scarring. Here we tested the hypothesis that the lack of scarring and resulting regeneration in adult Acomys skin also applies to the heart.