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Comparative study of the speed of acid‐suppressing effects of oral administration of cimetidine and famotidine

Background and Aim:  H2 histamine receptor antagonists (H2RAs) are widely used in patients with acid‐related diseases, and the onset of antisecretory activity of H2RAs is reported to be faster than that of proton pump inhibitors (PPIs). The aim of this study was to compare the rapidity of onset of antisecretory activity of cimetidine and famotidine when orally administered.