{'fraction_non_alphanumeric': 0.017921146953405017, 'fraction_numerical': 0.003942652329749104, 'mean_word_length': 5.475638051044084, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Pharmaceuticals and related drugs.

T current article is a survey of pharmaceutical and related methodology that has appeared in the literature between January 1, 2009 and December 31, 2010. It is directed exclusively toward the analysis of compounds in either their bulk or formulated forms and focuses on analytical procedures for evaluating quality, purity, strength, and stability. The Review does not deal with biochemical, clinical, metabolic, pharmacokinetic, or related aspects of the topic nor does it include the analysis of pharmaceuticals in the environment or food products. Book and book chapters also are excluded. Further, because of space limitations and the ever expanding base of scientific research and development work in the pharmaceutical industry, within the United States and throughout the World, the cited articles represent only a small fraction of the total number published during the reviewed period. Likewise, even though a cited paper may deal with more than one technique, it is discussed typically only once in the paper. In the selection of appropriate citations, an attempt was made to place greater emphasis on procedures related to newer compounds, emerging and/or highly used techniques, unusual approaches and methodology, and more comprehensive studies with only a few examples cited from the very large number of publications that discuss either more routine procedures, less often used techniques and approaches, or older compounds. The manuscript is organized similar to the last review published in this series that appeared two years ago in Analytical Chemistry, which contained an expanded general section and the techniques section combined into two broader areas. This was done to place more emphasis on general trends and emerging techniques and less on more routine methodology. Thus, the article is organized into three major sections: General, Separation-Based Methodology, and Spectrometric-Based and Other Methodology. These sections are arranged in terms of specific approaches and applications. As was noted in the last review, the discovery, development, manufacturing, and sales of pharmaceutical products has become an international industry that must meet the regulatory issues of a global marketplace and its influence on the changing nature of safety and efficacy. Further, individual market preferences and how these factors are influencing analytical requirements and associated methodologies are evident by the large amount of research papers originating from laboratories throughout the World. This, coupled with the increasing number of journals for reporting the work and their ease of access, has made it increasingly more difficult to pick representative examples from the worldwide body of literature being published.