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Estimation of Rabeprazole Sodium in tablet dosage form by rapid isocratic reversed phase high performance liquid chromatography using volatile buffer additives

A simple, rapid and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) assay method for determination of Rabeprazole Sodium (RS) in solid dosage form (20 mg) has been developed. Chromatographic separation was performed on YMC C 18 , ODS-AM stainless steel column (250 mm x 4.6 mm ID; particle size 5 μ). Mobile phase comprised of 50 m M ammonium acetate in water (pH 8) with ammonia and methanol. Detection was performed using PDA detector. Recovery of RS in tablets was 95.5-96.8%. Chromatographic response of the analyte (100-500 μg/ml) was linear with correlation coefficient more than 0.99. Runtime of the method is very short and mobile phase additives used are volatile that are also suitable for mass spectrometry analysis. Therefore, this method could be used for routine quality control analysis and in bio-analytical work.