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COMPARISON OF SERUM BDNF, IL-1β, IL-6, TNF-α, CRP, AND LEUKOCYTE LEVELS IN UNIPOLAR MANIA AND BIPOLAR DISORDER.

OBJECTIVE
Unipolar mania is not included in the DSM-5 as a separate diagnosis, although it is defined by widely accepted diagnostic criteria. The aim of this study was to investigate the differences between unipolar mania and bipolar disorder in terms of clinical and inflammatory parameters.


METHODS
The data of 495 hospitalized patients with bipolar disorder diagnoses were analyzed retrospectively. Forty met the diagnostic criteria for unipolar mania. Two patients refused to participate in the study. Thirty-eight unipolar mania patients and forty-two randomly selected patients with bipolar disorder diagnosis were included in the study. The two groups were compared in terms of sociodemographic, clinical characteristics, serum brain-derived neurotrophic factor, C-reactive protein, leukocyte, and cytokine levels.


RESULTS
A total of 40 (8.08%) of 495 patients diagnosed with bipolar disorder met the unipolar mania diagnostic criteria. The number of manic episodes and the number of hospitalisations were statistically higher in the unipolar mania group than in the bipolar disorder group. Among all the manic symptoms, the incidence of symptoms such as euphoria, increased sexual interest, grandiosity, and delusions were found to be statistically higher in the unipolar mania group. Interleukin-6 and C-reactive protein levels were significantly higher in the unipolar mania group than in the bipolar disorder group.


CONCLUSION
Unipolar mania differs from bipolar disorder in terms of clinical features and serum interleukin-6 and C-reactive protein levels.