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Characterization of digital waveforms using thermodynamic analogs: detection of contrast targeted tissue in mda 435 tumors implanted in athymic mice

We describe characterization of backscatter from tumor tissue targeted with a nanoparticle-based ultrasound contrast agent in vivo using analogs of thermodynamic quantities. We apply these waveform characteristics to detection of tumor neovasculature in MDA 435 tumors implanted in athymic nude mice, which were imaged using a research ultrasound scanner over a two hour period after injection of αvβ3-targeted perfluorocarbon nanoparticles. Images were constructed from backscattered ultrasound using two different signal receivers: Conventional and a thermodynamic analog (HC). The study shows that the thermodynamic analog is capable of detecting differences in backscattered signals that are invisible to the conventional approach.