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Preconditioning donor liver with Nodosin perfusion lessens rat ischemia reperfusion injury via heme oxygenase‐1 upregulation

Background and Aim:  Ischemia reperfusion injury (IRI) remains a major cause of graft injury, dysfunction and even failure post‐transplantation. Heme oxygenase 1 (HO‐1) has been found to be an attractive target for anti‐inflammatory therapies and a potential candidate responsible for cell injury. The objective of this study was to investigate whether preconditioning the donor liver with Nodosin perfusion upregulates HO‐1 and then lessens IRI in rat models.