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The cardiovascular responses to the addition of nitrous oxide to fluroxene in man.

SUMMARY The cardiovascular responses to the addition of 66 or 70 per cent nitrous oxide or nitrogen to steady-state fluroxene-oxygen anaesthesia, end-tidal concentration 5 or 9 per cent, was investigated in young healthy subjects. The reduction of oxygen concentration, on its own, increased heart rate and cardiac output and decreased systemic vascular resistance. Although these changes were noted only with 9 per cent fluroxene, nitrous oxide produced an alpha-adrenergic sympathomimetic response with 5 per cent fluroxene, but at 9 per cent a mixed alpha and beta response was obtained. Adding nitrous oxide and subtracting an equivalent amount of fluroxene produced a response similar to that seen when nitrous oxide was simply added to 5 per cent fluroxene. Comparing the response of nitrous oxide substituted for nitrogen eliminated some of the differences between the responses at light and deep levels. Since the response to adding nitrous oxide to fluroxene differed considerably from that seen with halothane or ether we can draw no conclusions concerning the circulatory action of nitrous oxide, and it would appear that we have observed an interaction between nitrous oxide and fluroxene.