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Plasma concentration changes in LH and FSH following electrochemical stimulation of the medial preoptic are or dorsal anterior hypothalamic area of estrogen- or androgen-sterilized rats.


 Plasma concentraption changes in luteinizing hormone (LH) and follicle stimulation hormone (FSH) following elctrochemical stimulation (ECS) of the medial preoptic area (MPOA) or dorsal anterior hypothalamic area (DAHA) of estrogen-or androgen-sterilized rats were compared with normal proestrous rats in which spontaneous gonadotropin surges had been blocked with Nembutal (control). ECS of control rats, AST, and ESR provoked marked increases in FSH by 120 minutes and peak levels by 180 minutes poststimulation. No differenses were seen when ESR of ASR plasma levels were compared with control values or to each other (ESR vs. ASR). DAHA-ECS did not provoke a marked LH rise in ASR and ESR. MPOA-ECS of control, ASR, and ESR resulted in the release of LH and FSH. FSH peaked in all groups at 240 minutes but at 120 and 180 minutes poststimulation plasma FSH levels were greater in ASR and ESR than controls. FSH in ESR was significantly higher (p. 05) at 120 and 240 minutes poststimulation. LH was elevated in all groups following MPOA-EDS but in ESR markedly greater LH levels were obtained at 60 and 180 minutes compared with controls or ASR. Preoptic stimulation of progesterone-treated ASR (P-ASR) did not induce greater release of FSH than in control, ASR, ESR, or P-ESR. Stimulation of P-ASR resulted in greater plasma LH rise by 60 minutes which was greater than ASR, P-ASR, ESR, or controls, followed by decreased levels to baseline in P-ESR. MPOA-ECS controls ovulated (8-13 eggs) whereas neither ASR nor ESR Fallopian tubes contained eggs the following morning. No DAHA-stimulated groups ovulated. All P-ASR but no P-ESR ovulated after MPOA-ECS. It is concluded that while exposure of neonatal female rats to estrogen renders them more sensitive than ASR to preoptic stimulation, the ovaries of these amimals are much less responsive to the gonadotropin released into plasma than are those of ASR or normal rats.
