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The role of hepatitis C virus in liver disease

When a serological marker for hepatitis C (anti-HCV) became available, due to the efforts of Dan Bradley, Michael Houghton and colleagues, investigators around the world went to their freezers and took out blood samples from patients with a spectrum of hepatobiliary disorders to examine the prevalence of the antibody in these diseases. At present, it is difficult to discuss the pathogenesis of HCVrelated chronic liver disease, but the prevalence of anti-HCV among various types of acute and chronic liver disease can be examined. This at least gives some insight into a possible causative role of the virus.