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Transcapillary passage of plasma proteins in experimental burns.

The “leakage” of proteins from plasma to interstitial fluid in burns was studied experimentally in dogs. The concentration of orosomucoid, α1-antitrypsin, albumin, haptoglobin, IgG, β1C-globulin and α2-macroglobulin were determined in plasma and in lymph from the leg before and after scalding of the paw. The lymph/plasma ratio of all proteins except that of α2-macroglobulin increased after scalding, indicating an increased capillary permeability to proteins with molecular weights up to 300,000.