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Are probiotics effective and safe for the treatment of vulvovaginal candidiasis in nonpregnant women?

Treatment of vulvovaginal candidiasis (VVC) with probiotics as an adjunct to standard antifungal therapy may slightly improve signs and symptoms of VVC for up to 14 days and decrease recurrences at one month, but the addition of probiotics has no significant effect on longer term cure rates when compared with antifungal therapy alone (SOR: B, systematic review of lowto very-low-quality randomized controlled trials [RCTs]). The addition of lactobacilli probiotics may slightly improve malodorous discharge symptoms as compared with clotrimazole treatment alone (SOR: B, single RCT with significant limitations). Probiotics appear to be as safe as placebo (SOR:B, systematic review of lowto very-low-quality RCTs). Copyright © 2019 by Family Physicians Inquiries Network, Inc. DOI 10.1097/EBP.0000000000000667