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[Histopathology and immunohistochemical expression of precursor lesions of cervical adenocarcinoma].

OBJECTIVE
To discuss the histopathology and immunohistochemical expression in precursor lesion of cervical adenocarcinoma-cervical intraepithelial glandular neoplasia (CIGN).


METHODS
Histopathological examination and immunohistochemical study (SP method) were performed on 101 cases of CIGN.


RESULTS
Criteria for histological grading of CIGN into three degrees, grade I to III, were proposed according to the hyperchromasia and the stratification of nuclei, number of mitoses and the amount of intracellular mucin. Adenocarcinoma in situ was classified as CIGN-III. 46.53% (47/101) CIGN showed a co-existence of CIN (SIL). 45 cases were CEA positive (44.55%) and 38 showed apical and luminal positivity. The positive rate of PCNA was 63.54% and was 100% in CIGN-III. The positive rate of ER was 81.48% (66/81). The expression of ER was often decreased or missing in certain cases. The positive rate of HPV 6/11 in CIGN I-III was 34.09% (30/88), 31.82% (28/88), and 3.41% (3/88), respectively.


CONCLUSIONS
Histological grading of CIGN is important. Immunohistochemical staining for CEA, PCNA and ER may be helpful in diagnosis and differential diagnosis of CIGN.