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Intrapancreatic schwannoma diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration cytology

Schwannoma is a tumor of neuro‐ectodermal origin, usually occuring in the head and neck and extremities. A retroperitoneal, and particularly intra‐pancreatic presentation is very rare, and poses a clinical and diagnostic challenge. We report a case of a male patient who underwent an Endoscopic Ultrasound‐guided Fine Needle Aspiration (EUS‐FNA) biopsy of a hypoechoic, intra‐pancreatic mass. The onsite cytological evaluation was consistent with a spindle cell neoplasm. Further evaluation, aided by immunohistochemical stains, defined the mass as a Schwannoma. The patient then underwent a pancreaticoduodenectomy and the histopathological diagnosis of the surgical specimen confirmed the cytological diagnosis. To our knowledge, this is the first report of intra‐pancreatic Schwannoma diagnosed preoperatively by EUS‐FNA cytology. Diagn. Cytopathol. 2009. © 2008 Wiley‐Liss, Inc.