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Relation of kveim-antigen reaction to lymphadenopathy. Study of sarcoidosis and other diseases.

Abstract Kveim tests in 37 selected patients with sarcoidosis demonstrated that a reaction could be related to persistent lymphadenopathy and not to duration or activity of illness. Fourteen asymptomatic patients with marked enlargement of the mediastinal and hilar lymph nodes of long duration all reacted strongly. Positive tests occurred in only three of 12 patients having disease of recent onset with minimal adenopathy, and in only one of 11 with active hepatic or cutaneous sarcoidosis and normal chest roentgenograms. The demonstration that the reaction is more closely related to lymphadenopathy than to granulomatosis led to tests in patients with lymph-node enlargement due to other diseases. Typical reactions were obtained in patients with chronic lymphatic leukemia, tuberculous adenitis, infectious mononucleosis and nonspecific cervical adenitis. The Kveim test appears to be an immunologic reaction associated with persistent lymphadenopathy of diverse causes.