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Micromolar calcium prevents isolated rat liver mitochondria form anoxia‐reoxygenation injury

Rat liver mitochondria were exposed to extramitochondrial free calcium between 0 and 5 μM and/or 5 minutes of anoxia followed by 10 minutes of reoxygenation. At concentrations higher than 4 μM, the membrane potential collapsed indicating the permeability transition of the mitochondrial membrane. Anoxia‐reoxygenation shifted this transition to lower calcium concentrations. Anoxia‐reoxygenation alone resulted in the decrease of ADP stimulated respiration down to about 40 % of its initial value. Between 1 and 2 μM, a protective effect in terms of respiration and oxidative protein modification was found. It is concluced that calcium may suppress the formation of reactive oxygen species during anoxia‐reoxygenation before permeability transition occurs.