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Reye's Syndrome in Thailand

Reye’s syndrome is a disease of children that has a high mortality rate in Thailand. Because of its low incidence, occurring in only a few parts of the country, it has received little attention from the public. This disease was first recognized in the northeastern region in the year 1969 as an acute encephalopathy resembling Reye’s syndrome [ 11 . It occurred in children aged 1-6 years, mostly female, living in suburban or rural areas, resulting in a 60-80% death rate. Aflatoxin B was proposed as one of the causes. The cases in Bangkok [ 2 ] were reported in 1971 from Children’s Hospital and then followed cases from other parts of the country. The epidemiology of Reye’s syndrome in Thailand could not be determined before 1979 because it was classified under the code of neurologic disorders, then later was recognized as a notifiable disease. Since the number of cases was always underreported and the complete epidemiology could not be ascertained from the Ministry of Health, we therefore conducted this study by collecting data from various parts of the country using the questionnaire method. syndrome in Thailand. 2 ) To determine the clinical characteristics of Reye’s syndrome.