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The effectiveness of the antioxidant aminothiol series on the model of multiple sclerosis

In the experiments on an reproducible adequate model of multiple sclerosis – experimental autoimmune encephalomyelitis as a result of the creation of pathological condition by immunization of guinea pigs with an encephalitogenic mixture in the complete Freund’s adjuvant, a pronounced inhibitory effect of the Ttriafen preparation was shown. The synthesized preparation of Ttriafen with antihypoxic and antioxidant properties on the experimental autoimmune encephalomyelitis model was used for chronic administration for 35 days, orally at a dose of 50 mg/kg. This drug is known to be free radical scavenger. A number of immunological indices and the clinical picture of neurological complications and the severity of central nervous system damage in experimental guinea pigs were studied. The circulating antibody production was estimated using the complement fixation test. In the peripheral blood, the content of lipid peroxidation products and antioxidant defense enzymes was evaluated. In another series of experiments, the lethality of animals after inoculation of the encephalitogenic mixture in Freund’s complete adjuvant and the protective effect of Triafen’s preparation were reproduced. In the present study, it has been established that the synthetic preparation of the aminothiol Triafen series on the experimental model of multiple sclerosis shows a neuroprotective and immunomodulating property, and increases the resistance to the intensification of LPO processes.