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Science Signaling Podcast: 16 July 2013

Proinflammatory signaling by tumor necrosis factor receptor 2 requires that it be released from nonmuscle myosin. This Podcast features an interview with Paul DiCorleto, author of a Research Article that appears in the 16 July 2013 issue of Science Signaling. Tumor necrosis factor–α (TNF-α) is a cytokine that promotes inflammation by binding to and activating TNF receptors 1 and 2 (TNFR1 and TNFR2). TRAF2 is an adaptor protein that is required for both of these receptors to activate downstream signaling and promote target gene expression. Whereas the mechanism by which TRAF2 is recruited to TNFR1 is fairly well characterized, less is known about how TRAF2 is recruited to TNFR2. Chandrasekharan et al. report that TRAF2 recruitment to TNFR2 in endothelial cells requires the release of nonmuscle myosin from the cytosolic domain of the receptor and that this release requires phosphorylation of myosin by the kinase ROCK1.