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Specific desensitization of the epidermal growth factor receptor by pp60v‐src

BALB/c 3T3 cells infected with a temperature‐sensitive mutant (LA90) of RSV have been used to investigate possible heterologous interactions between the pp60v‐src tyrosyl kinase and the epidermal growth factor (EGF) and bradykinin receptors. The LA90 pp60v‐src exhibits a very rapid activation t1/2 (<5 min) of protein kinase activity on decreasing the temperature from 40°C to 35°C. This change in temperature was also found to induce a very rapid decrease in the affinity for 125I‐EGF of receptors on the RSV‐LA90‐infected cells but not of those on control parental cells. However, no significant changes were detected in the binding of 3H‐bradykinin to either cell line. Two separable processes control the desensitization of the EGF receptor by pp60v‐src, both of which are independent of protein kinase C. The first is rapid and transient, while the second is sensitive to cycloheximide and persists long after inactivation of pp60v‐src.