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[Effect of experimental thinness and obesity on the delayed neurotoxicity of the organophosphorus pesticide "Phosvel" (author's transl)].

Phosvel is an organophosphorus pesticide known to produce delayed neurotoxicity. The author of this paper have previously reported that the residues or accumulations of Phosvel were detected in the adipose tissue of hens to which it had been administrated. This earlier investigation has suggested that the relationsphip between the delayed neurotoxicity of the pesticide and the role of adipose tissue in animals treated with the compound is an important problem to concider. In this study, neurotoxicity levels of Phosvel in three groups of hens, each given a different dosage, were compared. The groups consisted of seven subgroups of 5 birds each. After forced tubefeeding for 3 to 4 weeks, the first group was given 100, 150, 200, 300 and 500mg/kg body wt. of Phosvel. The another subgroup was given salad oil as a control. This is known as the 'obese group'. After fasting for 2 weeks, the second group was put under the same regimen-the 'thin group'. The third group was fed normally and was also put under the above regimen-the 'normally fed group'. In the subgroups which received a single dose of 100mg/kg of Phosvel, there were no abnormal hens. However, after a single dose of 150mg/kg, 2 out of the 5 hens in the normally fed group and 3 out of 5 in the thin group showed signs of ataxia and one of the normally fed group died. There were no abnormals in the obese group. Furthermore, hens which had received doses of 200mg/kg or more showed signs of even severer damage, especially those of the thin group. Of this group, 4 out the 5 birds treated with a single dose of 200mg/kg and all birds treated with 300 or 500mg/kg showed severe paralysis and died by 26th day after receiving the peticide. Before death, such hens were unable to recover the weight lost during the fast period. The incidence of delayed neurotoxicity in each group was 17/25 for the thin group, 8/25 for the obese group and 12/25 for the normally fed group. Mortality rates were 14/25 for the thin group, 1/25 for the obese group and 5/25 for the normally fed group. The thin group of animals with the smallest amount of fat tissue and which received that lowest dose of Phosvel in terms of brain weight showed significantly greater neurotoxicity. The results of present study suggest the following; 1) Phosvel administrated to hens attacks the target organ i.e. the brain, soon after its administration. 2) The possibility must be considered that there is increased sensibility to organophosphorus compounds when the fat tissue of animals is consumed by fasting, if the toxic effects of such compounds have been experimentally determined.