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CHILDHOOD OBESITY PREVENTION AND TREATMENT RESEARCH CONSORTIUM (U01): RFA-HL-10-004

This FOA, issued by the National Heart, Lung, and Blood Institute (NHLBI) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), solicits cooperative agreement grant applications from institutions to conduct randomized controlled trials to test innovative interventions that address issues immediately germane to the childhood obesity epidemic and runs parallel with a separate Funding Opportunity Announcement (FOA) that solicits applications a Research Coordinating Unit (see RFA HL-10-005 (http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-10-005. html)). The goal of this Funding Opportunity Announcement (FOA) is to fund randomized trials testing intervention approaches to prevent excess weight gain in non-overweight youth and in those already overweight, and/or to reduce weight in obese and severely obese youth. For the purposes of this FOA (RFA-HL-10-004) and RFA-HL-10-005, prevention of obesity is defined as prevention of excess weight in non-overweight youth (primary prevention), as well as prevention of additional weight gain in those already overweight or obese. Treatment is defined as reduction of weight (including weight loss or weight maintenance during linear height growth) in those already obese or severely obese. The whole program is designed to promote collaboration, coordination and exchange of scientific information among institutions, and partnerships with local, state and national agencies. The ultimate goal is to improve children’s health by preventing obesity-related morbidity and mortality from cardiovascular and other chronic diseases. This FOA targets young children, pre-adolescents and adolescents and encourages novel interventions. Applications will be accepted from multi-disciplinary research teams, networks or collaborative groups that are already established or will be formed to conduct high-quality, transdisciplinary research in childhood obesity prevention and treatment. The ultimate goal is to improve children’s health by preventing obesity-related morbidity and mortality from cardiovascular and other chronic diseases. This FOA will utilize the Research Project Cooperative Agreement (U01) grant mechanism. The participating organization(s) intend to commit approximately $4,250,000 total costs for FY2010. The total amount to be awarded through this announcement will be a maximum of $49,750,000 total costs for the seven-year project period. It is anticipated that up to four Research Centers (RC) (two prevention and two treatment) will be awarded. The total project period for an application submitted in response to this FOA is seven years. Maximum allowable direct costs for a Research Center are $700,000 in Year 1 and 2, $1,500,000 per year in years 3Y6, and $700,000 in year 7. The research plan may not exceed 25-pages. Eligible institutions and organizations include: public or state controlled institutions of higher education; private institutions of higher education; Hispanic-serving institutions; Historically Black Colleges and Universities; Tribally Controlled Colleges and Universities; Alaska Nativeand Native Hawaiianserving institutions; nonprofit organizations with 501(c)(3) IRS status (other than institutions of higher education); nonprofit organizations without 501(c)(3) IRS status (other than institutions of higher education); for-profit organizations (other than small businesses); state governments; Indian/ Native American tribal governments (federally recognized); Indian/Native American tribally designated organizations; U.S. territories or possessions; Indian/Native American tribal governments (other than federally recognized); regional organizations; eligible Agencies of the Federal Government; and faith-based or community-based organizations. Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. PDs/PIs time commitments must not be less than 2.4 calendar months (20% effort per year). More than one PD/PI (i.e., multiple PDs/PIs) may be designated on the application. Applicants may submit more than one application, provided they are scientifically distinct. Resubmission applications are not permitted in response to this FOA. Renewal applications are not permitted in response to this FOA. This FOA uses non-standard due dates. Complete details available at http://grants.nih.gov/grants/ guide/rfa-files/RFA-HL-10-004.html.