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Ø-adrenergic receptor function and regulation in hypertension

Alterations in platelet o2-adrenoceptor and mononuclear leucocyte ß2-adrenoceptor characteristics in primary hypertension have been studied quite extensively The results of these studies are not consistent, which may be due to the relatively small number of subjects in most of the studies. In the present study, the o2-adrenoceptor characteristics were compared between 65 hypertensive and 51 normotensive subjects and ß2-adrenoceptor characteristics between 72 hypertensives and 67 normotensives. No significant differences in a2and ß2adrenoceptor density were observed between the groups, but the dissociation constant for the o2-adrenoceptor was significantly lower in the hypertensive subjects. Correlations between adrenoceptor characteristics and clinical parameters were investigated, which resulted in a weak though significant correlation between the ß2-adrenoceptor density and mean arterial pressure. The results of the present study were compared with the most relevant studies in the literature From our study and the literature, we conclude that the blood cell adrenoceptor characteristics are unchanged in primary hypertension