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C/EBPα and C/EBPβ mediated genome‐wide combinatorial transcriptional regulatory dynamics during early onset of liver regeneration and chronic alcohol intake (398.6)

The primary objective of this study is to characterize effects of chronic alcohol consumption on genome‐scale transcriptional regulatory network dynamics during the early phase liver regeneration after 70% partial hepatectomy (PHx) at 6h post 2/3rd PHx in the rat. Rats were fed liquid diet containing 36% of total calories derived from ethanol for 5 weeks, controls were pair‐fed an isocaloric liquid diet with carbohydrate replacing ethanol. Genome‐wide binding targets C/EBPα and C/EBPβ were detected by ABI SOLiD sequencing approach and qPCR validation.