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Synthesis, spectral studies and biological activity of some novel biphenyl imidazo(2,1-b)(1,3,4)thiadiazole derivatives

In the present study, we have reported the synthesis of some novel heterocyclic derivatives comprising imidazole and 1,3,4-thiadiazole containing biphenyl moiety. Imidazothiadiazoles are of interest because of their diverse biological activities and clinical applications. Reactions of biphenyl carboxylic acid with thiosemicarbazide in the presence of phosphorous oxychloride resulted in biphenyl containing 2-amino-1,3,4-thiadiazole which is then further subjected to condensation with α-bromoarylketone under reflux in dry ethanol. Synthesized novel derivatives of imidazo[2,1-b][1,3,4]thiadiazole containing biphenyl moiety. The structures of the compounds (V a-h and VIII a-h) were elucidated by spectral studies and screened for antibacterial activity against various strains of Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis, and antifungal activity against Candida albicans, Saccharomyces cerevisiae and Aspergillus niger. The derivatives has shown moderate to good activity when compared with standard antibiotic Ampicillin and Amphotericin B. And the two derivatives were screened for anticancer activity to National Cancer Institute (NCI), USA.