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Towards a multimodal device for clinical in-vivo skin cancer depth measurements

Melanoma skin cancer is one of the most lethal types of cancer due to comparably early development of metastasis. As preventative medical check-up, optical inspection using polarized light (dermoscopy) is the gold standard in medical practise. If a lesion is diagnosed to be suspicious, it is subsequently excised by a surgeon and analysed by means of histopathology. However, optical inspection so far is hardly capable to reliably distinguish between healthy and cancerous tissue leading to large amounts of lesions which are unnecessarily excised. In addition, if cancerous tissue is confirmed by histopathology, additional skin is removed within defined safety margins to prevent spreading of metastasis [1]. These safety margins are chosen according to the penetration depth of the melanoma, which to date cannot be determined prior to the first surgical intervention.