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[Inspiratory-facilitated effects due to electrical stimulation of the nucleus raphe dorsalis in rabbits].

In 30 urethane-anesthetized,gallamine-paralyzed and vagatomized rabbits 
with artificial ventilation,efferent phrenic discharge was recorded to monitor central 
respiratory activity.Electrical stimulation of NRD elicited the following respira- 
tory effects:(1)A 6-10s train of pulses (100 Hz,duration 0.3ms,amplitude 4-6V) 
caused an increase of respiratory rate and integrated phrenic nerve discharge.(2) 
When a short train (0.4s) of repetitive stimulation was applied during the inspi- 
ratory phase,this phase would be prolonged.The most powerful effect occurred 
when a stimulus intensity of 0.15mA was applied at the middle 2/3 of the control 
phase.(3)When the short train of stimulation was applied during the expiratory 
phase,the expiratory phase was dramatically shortened with the precipitation of 
expiratory activity.The threshold for this phase-switching effect decreased 
progressively during the course of the expiratory phase.Possible mechanisms for 
those effects were discussed.