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Subclinic Hypothyroidism in Infants. Therapeutical and Diagnosis Considerations 7

The high response of TSH to the TRH is the first sign that is described in the impaired of the thyroid function, which is present with normal levels of thyroidal hormones (TH) and that is defined as subclinic hypothyroidism (ScH). There are some controversies about their ethiopathogenic mechanism, their related clinical aspects, response limit values of TSH to TRH, evolution and therapeutic conduct to be adopted. In order to try to bring some answers to these questions it was evaluated the behavior of 33 infants (CA 01·1.5y) 9 males and 24 females, hyperresponsives to the TRH test (30' cut-off level: 35 μUI/ml). Those patients were treated with LT4 (mean dose: 3.10 μg/kg/daily) in a variable period until obtaining the minimal age of 2 years old. The therapeutical support was stopped in 18 of 33 patients (54%) in order to evaluate persistence of ScH.