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LEAPS therapeutic vaccines as antigen specific suppressors of inflammation in four unrelated diseases

August 20-22, 2012 T L.E.A.P.S.TM Ligand Epitope antigen presentation system technology platform has been used to develop immunoprotective and immunomodulating small peptide vaccines for infectious and autoimmune diseases. Several products are currently in various stages of development, at the pre-clinical stage (in animal challenge efficacy studies). Vaccine peptides can elicit protection of animals from lethal viral (herpes simplex virus [HSV-1]; influenza A) infection or can block the progression of autoimmune diseases (e.g. rheumatoid arthritis as in the collagen induced arthritis model [CIA]; experimental autoimmunce myocarditis [EAM]). L.E.A.P.S. technology is a novel T-cell immunization technology that enables the design and synthesis of non-recombinant, proprietary peptide immunogens. Combination of a small peptide that activates the immune system with another small peptide from a disease-related protein containing a T Cell epitope allows the L.E.A.P.S. vaccines to activate human monocytes or mouse precursors to differentiate and become mature dendritic cells (DCs) that can initiate appropriate T cell responses. As such, readily synthesized, defined immunogens can be prepared to different diseases and are likely to elicit protection or therapy as applicable in humans as they do in mice. L.E.A.P.S. vaccines have promise for the treatment of rheumatoid arthritis and other inflammatory diseases and infections, such as influenza and HSV1. The protective responses are characterized as Th1 immune responses with associated antigen specific IgG2a antibodies and reduced inflammatory cytokines (TNF-γγand IL-1, IL-17) modulated by DC and T cells. They have been used directly in vivo or as ex vivo activators of DC which are then administered to the host.