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Thrombogenic Properties of Vascular Catheter Materials in Vivo

Thrombo-embolism following catheterization of blood vessels appears to be due mainly to the formation of thrombi on the catheter (JACOBS SON & SCHLOSSMAN 1969). It is, however, not known whether such thrombus formation varies with the composition of the catheter material. This may perhaps be explained largely by the absence of a suitable method for comparing thrombogenic properties. SCHLOSSMAN (1973) regarded thrombogenic properties of a given material as their tendency to initiate thrombus formation. He also described a device for simultaneous formation of thrombi on various catheter materials in vivo. Experiments with this device reflected the degree of early thrombus formation, particularly as judged from the amount of labelled platelets in the thrombi. Since adhesion and aggregation of platelets are the first steps in the formation of a thrombus it was considered justified to regard the amount of platelets in freshly formed thrombi on the catheter as a good measure of the thrombogenic properties of the actual product examined.