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Giant cell tumor of bone in elderly patients: a study of ten patients.

Giant cell tumor of bone, sometimes referred to as conventional giant cell tumor, is a benign locally aggressive neoplasm which accounts for five percent of primary osseous neoplasms. Giant cell tumors most commonly occur in the distal femur, proximal tibia and distal radius. This neoplasm usually affects young adults; about two thirds of patients are between ages 20 and 40. Giant cell tumor is very unusual in patients older than age 55.1 This study reports ten patients with giant cell tumor who range in age from age 62 to 78. We discuss whether giant cell tumors in elderly patients behave differently than those that occur in the usual age group. In addition, we outline how problems of differential diagnosis in this age group differ from those in conventional patients.