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[Testosterone deficiency in elderly men].

The aging results in declining in serum concentrations of testosterone in men and some of them will develop signs and symptoms of testosterone deficiency syndrome (TDS) with its clinical and metabolic consequences. TDS, which is observed in about 6-12% men over 45 years old, reduces quality of life and may pose important risk factors for sexual disorders, cardiovascular diseases, metabolic syndrome, diabetes type 2 and osteoporosis. Testosterone replacement therapy is acceptably safe provided established guidelines are adhered to. Testosterone supplementation restores metabolic parameters to the eugonadal state, increases muscle mass and strength, improves bone mineral density and psychological function (cognition and mood), libido and sexual functioning; and enhances quality of life. The most commonly used therapy of TDS are injectable intramuscular testosterone esters and testosterone gels.