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Science, Art and Technology Sat 2006 Conference Proceedings

The aim of the presentation is to illustrate how modern nuclear physics, radiation biology and accelerator physics together can help solving one of our most difficult medical problems. Multiple examples of the beauty of the individual dose distributions obtained with different radiation modalities and of the advanced science and technology needed for optimal patient cure, will be presented. Radiation therapy is today in a state of very rapid development with new intensity modulated treatment techniques continuously being developed. To be able to cure also the most advanced hypoxic and radiation resistant tumours of complex local spread, intensity modulated light ion beams will really be our ultimate tool for cancer cure. Biologically optimized intensity modulated photons, electrons and light ions represent the ultimate development of radiation therapy where the absorbed dose and biological effect to normal tissues are as low as physically possible at the same time as the therapeutic effect on radiation resistant tumors is as high as possible. The only problem with the ions is the large capital cost requiring an initial investment in the order 100 MEUR. However, once the new treatment method is up and running the society will save the same amount of money per year due to a higher curability and less cost for palliative chemotherapeutic treatments. Light ions will be the ultimate radiation modality to exploit the genomic instability, the hallmark and Achilles heel of all tumors, in short, cost effective treatment schedules with minimal normal tissue morbidity as well as surrounding healthy tissues.