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Stereotactic Body Radiation Therapy–Induced Abscopal Effect on Hepatocellular Carcinoma After Treatment for Lung Cancer: A Case Report

The abscopal effect is a phenomenon in which localized radiation treatment is associated with cancer regression at a site distant from that irradiated. Stereotactic body radiation therapy (SBRT) delivers precise high-dose radiation treatments to tumors while minimizing exposure of surrounding normal tissue. SBRT is standard treatment for many primary and metastatic cancers and has an increasing role in the treatment of hepatocellular carcinoma (HCC).(1) The abscopal effect after radiation treatment is theorized to result from radiation “priming” of the immune system, enhancing immune recognition through increased antigen presentation, resulting in antitumor effects outside irradiated areas. We report an unusual case of HCC regression after SBRT to a different primary cancer in the lung.