{'fraction_non_alphanumeric': 0.035414165666266505, 'fraction_numerical': 0.025210084033613446, 'mean_word_length': 4.890459363957597, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 1, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Thrombopoietin as an Independent Prognostic Marker in Chronic Lymphocytic Leukemia.

Several cytokines and growth factors are involved in the regulation of megakaryocytopoieses and platelet formation. Interleukin-11 (IL-11), IL-6, IL-3, IL-1b, and thrombopoietin (TPO) act synergistically to promote proliferation and maturation of megakaryocytes. Recombinant IL-11 and TPO are under clinical investigation as supplements to stimulate thrombopoiesis in patients with cancer. We investigated the plasma levels of TPO in 127 patients with chronic lymphocytic leukemia (CLL) and correlated these levels with platelet counts and various laboratory and clinical characteristics. TPO levels were significantly higher in patients with CLL (median, 232 pg/mL; range, 26.4–2714.5 pg/mL) than in healthy control subjects (P H gene (P H mutation status, b2-M levels, and Rai stage. Recursive partitioning showed that a cut-point of 639.4 pg/mL separated CLL patients into two major groups with a significant difference in survival (P 639.4 pg/mL. However, among patients with TPO levels =639.4 pg/mL, those with b2-M levels >4.95 mg/L had significantly shorter survival than those with lower b2-M levels. These data not only emphasize the importance of TPO in reflecting the aggressiveness of CLL, but also suggest that TPO and b2-M can be used to predict clinical behavior in this disease and may replace the need for determining IgV H mutation status. Further studies are needed to determine if the prognostic role of TPO is due to its direct effects on the growth of the leukemic clone or simply reflects a general failure in the homeostatic regulation of various cytokines.