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The Flunarizine on Treatment of the Menses Migraine. Comparison with Dopamine and Prostaglandine Inhibitor (Domperidone and Suprofene)

Many authors have seen good results in migraine therapy with flunarizine. The aim of this trial is to see the results with flunarizine in a special headache of women: that occurs during the menses. For this one hundred of these cases of menses headache were treated for one year: thirty of them had headache only during the menses period; in seventy of them the headache was also in other days of the month. They were valued: for every month the frequency and duration of the migraine, the consumption of analgesic drugs, the accompanient troubles, the association with abdominal pain before, during or after the mense. We have found only a few cases with abdomen pain, while in 40 of 70 cases affected by migraine occurring more often in a month, the increasing headache was different before, during or after the mense. This variability could happen in the same woman every month, or could change after some years: in these cases the increase of migraine can pass gradually to the next period without any variation on the rythm, quantity or duration. Instead the migraine occurring in the 30 women only before the mense had no variation also when in some cases (11 in 30) the mense was irregular with advance or retard. To every woman was given 10 mg. of flunarizine in the evening for one year with interruption of a month every two months of therapy. Results were: in the seventy women affected by frequently headache in more time during a month, the headache disappeared or recovered (80%); the headache during only the menses seldom disappeared, but in many cases (40%) were smaller in intensity, duration and consumption of analgesic drugs. The thirty cases with only menses headache did not improve with flunarizine: they were with non response to dopamine (domperidone) or prostaglandine inhibitor (suprofene) drugs given during the menses. These drugs got better results in the cases with headache occurring in the other days of the month: in these cases their association with the flunarizine during the menses period seems the better therapy. Many authors have found in the days before mense migraine and other troubles as abdomen pain or holding water, and in this period also the reduction of substances endorphine like. It's very difficult to think this event was only cause of the mense migraine: really the reduction of some substances endorphine like occurs also during common migraine which has a good results with some drugs or alone as flunarizine or associated to other drugs which react upon different systems (as serotoninergic, dopaminergic, adrenergic) or prostaglandine substances which are considered the more important causes of common migraine. Instead the migraine only rising before mense has often no modification towards every therapy. Besides we have not confirmed yet the fall of the substances endorphine like happening in the migraine also occurring after or during the mense. For these observations it's possible to think the mense migraine is due by different factors which are not modified by these drugs.