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Effect of chlorinated alkanes on hepatic triglyceride secretion.

The effect of a series of monochloroalkanes (1-chloropropane through 1-chlorohexane) and a series of dichloroalkanes (1,2-dichloroethane through 1,5-dichloropentane) on hepatic triglyceride secretion in vivo and in vitro was investigated. It was demonstrated that a dose related decrease in hepatic triglyceride secretion is a common effect produced by both series of chlorinated alkanes. Using isolated hepatocytes a positive correlation between chlorinated alkane potency and increasing solvent lipid solubility was observed. However, this order of potency did not correlate with in vivo findings in which the less lipid soluble solvents were found to be the most potent. Possible reasons for the discrepancy between the two systems are proposed. It is suggested that the lipophilicity of the chlorinated alkanes may be important factor in solvent induced inhibition in triglyceride secretion.