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The use of liposomes in the diagnosis and treatment of malignant disease.

The non-specificity ofpharmacologically active agents is an obstacle to their effective use either in therapeutic and diagnostic purposes or in biological research. Recently, the ability of liposomes to encapsulate solutes, thereby sequestering them from the surrounding medium, together with the potential for sitespecific delivery in vivo has stimulated interest in their use as drugs and radio-diagnostic carriers as well. Encapsulation in the liposome also protects the drug from degradation while in transit to the target, and may alter the pharmacokinetics of distribution, metabolism and clearance.