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The Visualization of Mitochondrial Viscosity in Inflammation, Fatty Liver, and Cancer Living Mice by a Robust Fluorescent Probe.

Elucidating the internal relationship between diseases and mitochondria viscosity remains a great challenge due to the lack of the studies on multi-disease living animals. So far, demonstrating the abnormal mitochondria viscosity in the fatty liver and tumor living mice has not been achieved. To address this critical challenge, a powerful two-photon and mitochondria-targeted fluorescence probe CBI-V was herein designed for viscosity detection with deep red emission. Utilizing the new probe CBI-V, the mitochondrial viscosity alteration in living systems caused by Monensin or nystatin has been real-time monitored sensitively and selectively. Moreover, the probe is capable of imaging mitochondria viscosity in the inflammatory models at cells, zebrafish, and mice level. Importantly, the visualization of mitochondria viscosity has been achieved both in fatty liver and tumor living mice for the first time. This work not only advances the study of the relationship between disease and mitochondrial viscosity, but also opens up an efficient way for diagnosing mitochondrial viscosity related diseases.