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CRYSTALLIZATION OF ACETAMINOPHEN IN NANO/MICRO SCALE USING SWIRL MIXING MICRO DEVICE UNDER PRESSURIZED CARBON DIOXIDE

The fabrication of acetaminophen particles via supercritical antisolvent process with CO2 as an antisolvent was studied. The experiments were conducted at temperatures of 35-50 o C and pressures of 8-15 MPa with 5-15 ml/min CO2 flow rates. As a starting material, acetaminophen powder was dissolved in dimethyl formamide (DMF). Results of UV–vis spectrophotometry and GC-MS (gas chromatography mass spectrometry) analysis showed that there was no remaining DMF solvent in the acetaminophen particles products. It indicated that CO2 has successfully removed DMF from acetaminophen particles products. The surface characterization by using fourier transform infrared spectroscopy (FT–IR) showed that the CO2 solvent did not impregnate to the acetaminophen particles products. Results from scanning electron microscope (SEM) images showed that the acetaminophen particles products were successfully prepared in non-spherical shape morphologies with size less than 1 m. Based on the result; this process seems a powerful method to modify the acetaminophen powder physically such as particle size reduction.