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Carbon Monoxide Production in Patients with Breast Carcinoma

Total haem catabolism has been studied through measurement of endogenous production of carbon monoxide (V co) in 19 patients treated for breast carcinoma. The subjects were divided into three groups. Group A included six patients with haemoglobin (Hb) concentration greater than 11.5 g/dl and considered free from disease. Group B consisted of seven patients with distant metastases and Hb concentration greater than 11.5 g/dl and group C of six patients with distant metastases and anaemia (Hb concentration less than 11.5 g/dl). V co in group A was 10.3 ± 3.7 (mean±1 SD) and in group B 9.0±2.5 μmol/mmol total body haem (TBH)/d. These values are not different from our normal values of 10.8 ± 2.8 μmol/mmol TBH/d. In group C V co was 21.1 ± 3.1 (an increase of 100%).