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The energy request of inflammation.

The paper by Marion den Boer et al. (1), in this issue, addresses an important but complex topic: the role of antiinflammatory cytokines (IL-10) in energy metabolism. Surprisingly, their results appeared to be negative with respect to peripheral insulin-mediated glucose uptake. However, the authors did report effects on fat metabolism in general, particularly in the liver. Their findings represent an important contribution to understanding the network that links inflammatory processes, energy metabolism, and the behavioral state.