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[Detection of TTV DNA in liver tissue of patients with non A-G hepatitis].

OBJECTIVE
To study the existence of TTV (transfusion-transmitted virus) in liver tissue of patients with non A-G hepatitis.


METHODS
19 cases of paraffin-embedded liver tissues of the patients with non A-G hepatitis were studied by in sity hybridization with Dig-TTV DNA probe.


RESULTS
Out of 19 cases, TTV DNA were detected in 6 cases, including 4 cases of acute mild hepatitis (30.80%) and 2 cases of chronic hepatitis (33.33%), respectively. Hybridization signals were detected within the nuclei or cytoplasm of the hepatocytes. The positive cells were scattered in the intralobular areas in acute mild hepatitis and more aggregated in periportal areas in chronic hepatitis. Among the 6 positive cases, 5 had a raised ALT.


CONCLUSION
The result showed that the TTV detected in liver tissue of patients with unknown etiology is a novel virus, which belongs to an hepadnavirus.