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Guess what: Chronic 13q14.3+/CD5−/CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23− mantle cell lymphoma in lymph nodes!

We report a case of a patient with two B‐cell lymphoproliferative disorders: CD5−/CD23+ B‐cell chronic lymphocytic leukemia and CD5+/CD23− mantle cell lymphoma. These disorders were diagnosed simultaneously based on flow cytometry, immunohistochemistry, fluorescence in situ hybridization, and polymerase chain reaction–based molecular studies. The B‐cell lymphocytic leukemia clone predominated in the blood and bone marrow, whereas the mantle cell clone predominated in lymph nodes. Cytometry Part B (Clin. Cytometry) 51B:41–44, 2003. © 2002 Wiley‐Liss, Inc.