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Properties of stored red blood cells: understanding immune and vascular reactivity

Blood transfusion is an integral component of life-saving fluid resuscitation for anemic, surgical, oncological, and severely injured patients. However, there have been well-publicized studies suggesting that blood may have harmful side-effects. One possible factor contributing to adverse effects of transfusion is the duration of red blood cell storage prior to transfusion. Our group is exploring possible mechanisms of a putative “storage lesion”, including measuring modulation of the immune system or changes in adhesion properties between endothelial cells and transfused red blood cells. The following review will explore changes that occur during red blood cell storage and how these might impact pathways that are important in transfusion recipients’ clinical outcome, as well as provide a broad overview of the research our group is performing on the topic.