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Presence of antibodies to the viral proteins in sera of mammals bearing RSV-induced tumours.

The sera of RSV tumour-bearing rats, hamsters and monkeys were tested for the presence of antibodies to RSV proteins. Complement fixation test and radioimmunoprecipitation followed by SDS-polyacrylamide gel electrophoresis were used for detection of antibodies to the products of the gag, env and src genes of RSV. Antibodies to the env and gag gene products were found in sera of tumour-bearing monkeys. Hamster sera contained antibodies to the gag gene products only. No antibodies were detected in sera of tumour-bearing rats. The differences in immunogenicity of RSV gene products in various hosts are discussed.