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Carbon dioxide laser treatment promotes repair of the three‐dimensional network of elastic fibres in rat skin

Background  We have previously reported that ultraviolet (UV) B irradiation induces a loss of linearity in the three‐dimensional structure of dermal elastic fibres, which results in the reduction of elastic properties of the skin and leads to wrinkle formation. We further reported that repair of wrinkles by all‐trans retinoic acid is accompanied by recovery of the linearity of elastic fibres. Carbon dioxide (CO2) lasers are widely used for treating wrinkles in cosmetic surgery.