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Studies in sarcoidosis: intradermal Mycoplasma test.

Mycoplasma strain 215-M, closely related to Mycoplasma orale type 1, was grown in human macrophage monolayers in vitro. Sonicated homogenates of macrophages diluted in saline solution were used for intradermal skin tests in 19 patients with sarcoidosis and in 25 patients with a variety of other diseases. Positive skin-test reactions to this newly developed Mycoplasma test material were observed significantly more often in the patients with sarcoidosis than in the other patients.