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The renal clearance of practolol in man

The results indicate a dependence of the amount of drug retained in the matrix on the feeding conditions before its administration. Condition 1 demonstrates almost complete release of drug from the matrix; thereafter, as the amount of food present at the time of dosing is increased, there is a corresponding increase in the amount of drug which is not released in vivo. This is probably due to the tablet becoming embedded in the food mass, which affects the penetration of water into the pores of the matrix, and thus inhibits dissolution and hence release of drug. This effect could introduce a large degree of variability into blood levels achieved with such a tablet, and is apparently a restriction on the use of this type of sustained-release formulation.