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β Amyloid does not activate the antioxidant pentose phosphate pathway within the B12 neural cell line

THE aim of this study was to determine whether neural cells exposed to β amyloid (Aβ) activate the pentose phosphate pathway (PPP), a critical oxidative stress defense mechanism. Aβ stimulated H2O2 production in neural (B12) and non-neural (HepG2) cells and stimulated PPP activity, the source of the main intracellular reductant NADPH, in HepG2 cells (67% increase). Catalase blocked the Aβ-induced increase in PPP, demonstrating that H2O2 mediated the increase in PPP activity. B12 cells showed no increase in PPP following Aβ exposure. Fifty-five per cent of HepG2 cells but only 11.1% of B12 cells remained viable after Aβ exposure. Lack of PPP activation may contribute to Aβ cytotoxicity in neural calls and may lead to differences in survival between neural and non-neural cells.