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Robotic versus laparoscopic splenectomy: a systematic review of perioperative outcomes

Elective splenectomy has various indications and can be performed open or minimally invasively. Laparoscopic splenectomy (LS) is popular but has limitations. Some studies suggest potential superiority of robotic splenectomy (RS) over LS. As such, we conducted a systematic review to determine whether RS has greater positive perioperative outcomes in comparison to LS in the adult population. We searched for studies that reported perioperative outcomes and compared RS to LS in the adult population. Outcome measures were operative time, conversion to open surgery, postoperative complications, mortality, length of stay, blood loss and cost analysis. A simple, unpaired two-tailed student’s t‑test was used to compare outcomes between the RS and LS patient groups. After full-text analysis of 47 papers, three studies met the inclusion criteria. The studies involved 72 patients (28 in the RS group, 44 in the LS group). RS demonstrated no significantly reduced blood loss in comparison to LS (p = 0.13). RS had no cases converting to open surgery and no postoperative complications in comparison to LS. No significant difference was found between RS and LS with regards to LOS (p = 0.89) and cost benefit (p = 0.74). RS had a higher operative time in comparison to LS which was not statistically significant (p = 0.45). The RS approach may be associated with lower blood loss and a lower risk of conversions. There was no statistical difference between RS and LS with regards to length of stay (LOS) and cost. RS takes longer to perform in comparison to LS.


Introduction
Elective splenectomy has many indications and can be performed via an open approach or in a minimally invasive manner [1]. Since the inception of laparoscopic splenectomy (LS) [2], improvements of laparoscopic tools for ligation over time have popularised the approach [3]. However, LS does have its limitations, such as a steep learning curve [4]. Multiple review studies have reported that in difficult operational circumstances such as splenomegaly, obesity, haematological malignancies and previous laparotomies, LS is associated with increased morbidity and conversion rates to open surgery [5][6][7][8].
With the introduction and increasing availability of the surgical robot in the operative arena [9,10], general surgeons are adopting the robotic platform to benefit from its markedly advanced endowristed instruments [11]. While both laparoscopic and robotic surgery are classed as minimally invasive techniques, there are studies which appear to suggest superiority of robotic splenectomy (RS) over the laparoscopic approach [12,13]. As such, we conducted a systematic review to determine whether RS has greater positive perioperative outcomes in comparison to LS in the adult population.

Literature search
This systematic review has been registered on the Prospective Register of Systematic Review Protocols (PROSPERO ID: CRD42020196831). This study adhered to the 'Preferred Reporting Items for Systematic Reviews and Meta-Analysis' (PRISMA) guidelines ( Fig. 1). Authors A.S.B. and A. F. independently per-review formed a literature search using the search engines Embase, PubMed, Web of Science and Cochrane Library for literature that directly compared RS with LS for adult splenectomy procedures where indicated. Search terms employed were the following: robotics, laparoscopic, splenectomy, spleen, surgical procedures. In addition, the reference lists of the included articles were also screened for additional information on the subject matter. There were no language limitations set for this literature search dated up to and including the 31 December 2020.

Inclusion and exclusion criteria
Inclusion criteria for this study were 1) patients with any indication requiring splenectomy or partial splenectomy; 2) published studies comparing robotic splenectomy (RS) with laparoscopic splenectomy (LS); 3) studies reporting at least one of the following outcomes-operative time, conversion to open, blood loss, hospital stay, cost, postoperative complications, morbidity, mortality; 4) study design-randomised controlled trials (RCTs), cohort studies, observational studies or comparative studies.
Studies meeting the following criteria were excluded: 1) studies showing no comparison between RS and LS; 2) case reports, case series, systematic reviews, conference abstracts, experiments or conference reports; 3) any studies where the full text was unavailable despite contacting the authors; 4) studies that included a paediatric population.

Study selection and data extraction
Three reviewers (A.S.B., A.F., and V.K.) independently read the full relevant texts and extracted data pertaining to corresponding author, year, country, sponsorship, affiliated institution, population studied, type of surgery, study design, interventions and comparisons, and overall study outcomes. For any studies that were deemed to have missing information regarding these parameters, the authors were contacted via the contact address provided in the text.

Statistical analysis
To compare quantifiable perioperative parameters between the RS and LS groups, a simple, unpaired twotailed student's t-test was used. Bodner et al. [15] 2005 Austria Case-control Robotic vs. laparoscopic splenectomy 12 6 6 Belravichus et al. [16] 2015 Russia Retrospective cohort Robotic vs. laparoscopic splenectomy 21 10 11 Quality assessment for included studies Included studies were assessed for methodological quality by three researchers (A.S.B., A.F., and V.K.) using the widely used and established Newcastle-Ottawa scale (NOS). Parameters such as the selection of study, population and comparability of the groups under study and end outcome assessment were used to score the full texts included. The maximum possible score on the scale is 9 stars. A score > 5 stars was assigned to a study deemed to have a high methodological quality and low risk of potential bias. Any disagreement between authors was resolved by an agreed consensus.

Results
There were 47 potential studies that satisfied the inclusion criteria in the initial search ( Fig. 1). Of these, we excluded 44 articles with reasoning as follows: 14 due to incorrect study design; 12 were conference abstracts; 8 studies used the wrong comparator; 2 studies were video presentations; 2 studies were in the wrong setting; 5 studies consisted of a paediatric population and 1 study used the wrong intervention. For the final systematic review, we included three studies involving a total of 72 patients (28 in the RS group, 44 in the LS group) published between and inclusive of 2005 and 2018. The characteristics of the three studies are further listed in Table 1. Two of the three studies are RCTs [14,16]. The remaining article is a case-control study [15]. All three studies involved conducting a splenectomy. Data obtained from all three included studies are listed in Table 2 and detailed below.

Operative time
The mean operative time for the RS group was longer in comparison to the LS group; however, this was not statistically significant (182.63 min versus 142.33 min, respectively, p = 0.45). Only one study [15] specifically stated that the same surgeon's expertise was used for conducting both RS and LS procedures.

Conversion to open surgery
In total, there were 5 LS procedures that were converted to open surgery out of a total of 44 LS procedures across all studies. No RS were converted to an open procedure. Only one study [15] reported no group (RS or LS) having to convert to open surgery.

Postoperative complications
The RS group reported no postoperative complications. In total, 5 LS procedures involved postoperative complications. Observing a further breakdown of the Clavien-Dindo classification per individual patient case (Table 3), the LS group in [14] reported two grade II complications (one retroperitoneal haematoma and one postoperative pneumonia) and one grade IV complication (one re-operated for massive hemoperitoneum on the first operative day and died 24 h later due to multiple organ failure). The LS group in [16] reported two grade IV complications (one left-sided hydrothorax and one postoperative collection in the region of the edge of the resected spleen).

Mortality
Only one study [14] reported a single case of mortality which belonged to the LS group. The remaining studies [15,16] reported no mortality for the RS and LS groups.

Length of stay
Mean LOS was not significantly different between RS and LS groups (6.7 days versus 6.6 days, respectively, p = 0.89).

Blood loss
Two studies [15,16] reported blood loss. Of these studies, the mean blood loss of the RS group was lower in comparison to the LS group, although this was not statistically significant (111.1 ml versus 282.5 ml, respectively, p = 0.13).

Additional perioperative outcomes
Only one study [15] reported the time taken to insert trocars and establish pneumoperitoneum. The findings reported the RS group achieving this outcome within an average of 26 min, while the LS group managed it within an average of 10 min.

Bias assessment
The Newcastle-Ottawa scale (Supplementary Table 1) was used to assess bias in these studies due to their study design. This showed that all included studies [14][15][16] scored 8 stars out of a possible 9 stars and thus had a low risk of potential bias.

Discussion
This study highlighted RS to have reduced blood loss in comparison to LS [15,16]. In particularly difficult cases involving malignant hemopathies, splenic tumours, partial splenectomy and splenectomy in liver cirrhosis, the RS approach may prove to be potent for decreasing the risk of haemorrhagic complications during surgery and performing minimally invasive splenectomy where the LS approach has proven to be very difficult [17].
198 Robotic versus laparoscopic splenectomy: a systematic review of perioperative outcomes K review The RS approach was reported to have no patient cases converting to open surgery and no postoperative complications or mortality in comparison to LS. In addition to these findings, breakdown of the postoperative complications revealed that a larger proportion of postoperative LS complications were classed as grade IV [14,16]. These findings are largely consistent with a recent meta-analysis comparing RS and LS in the surgical management of non-traumatic diseases of the spleen. The study showed RS to have both significantly lower conversion rates to open surgery and postoperative complications in comparison to LS. Perioperative mortality was not observed in the RS group [18].
We found no significant difference in LOS in the three studies that were compared. One study based in Austria [15] attributed similar and relatively longer LOS for both RS and LS due to less pressure from insurance companies in comparison to the United States. In this regard, previous research of the US healthcare system has elucidated nonclinical factors such as race, education, gender and socioeconomic status to be associated with patients being uninsured and experiencing a longer LOS [19]. We can provide two counter arguments validating shorter LOS. The first is that a prolonged LOS has the potential to deny healthcare access to critically ill patients to timely access to treatment. The second is that patients with prolonged LOS are also at a higher risk of developing nosocomial infections and subsequent unplanned hospital readmissions, which, in turn, disadvantages both patients and hospitals alike [20,21].
Another important issue raised when comparing RS and LS modalities is cost analysis. Our findings indicated that there was no significant procedural cost difference between the two approaches [15,16]. It is important to consider that in the two studies that reported this parameter, the currencies used to calculate the total costs for the procedures were not the same, making it difficult to comparatively analyse the cost benefits of both RS and LS. In addition to this, there are currently only two studies comparing the costs in US dollars between RS and LS, which involve both adult and paediatric populations. Both studies concluded that while RS is more expensive than LS, it is feasible [22,23].
Our study found RS to have an increased operative time in comparison to LS. It is likely that the published series on RS are from the early adopters of robotic surgery, hence the longer operating times. Setting up and docking the robot adds time to the procedure. Finally, most robotic surgeons would agree that due to the 3D-HD × 10 magnified view, they see more unnamed blood vessels and to secure these with clips requires frequent instrument exchanges which adds time to the surgery. Hopefully, with the introduction of advanced energy devices (e.g., SynchroSeal ® Intuitive Surgical), operating times will improve. A retrospective cohort study by Giza et al. compared RS and LS approaches and was conducted over a span of 17 years [24]. In this study, patients were assigned via a scoring system to one of two groups-simple or complex, according to the degree of surgical complexity. The researchers found that for complex, difficult splenectomies, the robotic system was significantly beneficial. Further studies that stratify splenectomy procedures according to surgical complexity will enhance our understanding of the role of RS in complex procedures.
Our study is significant in that it evaluates the perioperative parameters involved in both RS and LS. However, there are a few limitations to our findings. First, many articles were excluded from our systemic search because they focussed on surgeries other than minimally invasive splenectomies. Second, there was heterogeneity in our results due to the limited number of articles that were analysed that satisfied our inclusion criteria. Third, due to the limited adult patient volume analysed in this study, the power of our findings is relatively low. Fourth, this study could not analyse the long-term outcomes of both RS and LS due to lack of data. We must also mention the possibility of selection bias in the robotic group, as in most cases this was a novel procedure.
In conclusion, our systematic review has shown that RS was associated with lower blood loss, a lower risk of conversion to open surgery and fewer postoperative complications. However, there was no significant difference between RS and LS in terms of LOS and cost benefit. Lastly, RS had a higher intraoperative time in comparison to LS. While these findings are encouraging in favour of RS, it is important to emphasise that further larger-scale comparison studies are required to be conclusive.