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[Effect of ascorutin on the thiamine level and ascorbic acid metabolism in rats subjected to exertion of various degrees of intensity].

Content of thiamin and metabolism of ascorbic acid were studied in 150 male rats administered with ascorutin (vitamins C and P complex) after physical exercises within 10, 15 and 20 days. Content of the vitamins studied was decreased depending on duration and severity of the physical exercises. High doses of ascorutin simultaneously with physical exercises normalized the ascorbic acid content in adrenal glands and increased the vitamin concentration in blood. At the same time, ascorutin caused different decrease in content of thiamin in blood and liver tissue accompanied by a marked decrease of the transketolase activity in blood and by an increase in the TDP-effect. The data obtained suggest that ascorutin should be combined with compensatory doses of thiamin.