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[Distribution of extracellular viral antigen of epidemic hemorrhagic fever in human autopsy cases].

Using improved immunohistochemical methods, repeated PAP and repeated PAP + ABC, we found in the extracellular spaces of autopsy cases of epidemic hemorrhagic fever large amount of viral antigens. Two forms of antigens were found: diffuse soluble antigen and inclusion body like granular antigen. The former was mainly G2 protein and the latter was mainly N protein. They were found in serum, lymph, CSF, edema fluid, fluids in renal, seminal tubules, alveolar and bronchial spaces, peptic, intestinal, pancreatic and thyroidal secretions. In most patients, the diffuse antigens were accompanied by IgG and C1q. A large amount of antigens, were excreted from the patients.