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Evidence for selective inhibition by lysophosphatidylcholine of acetylcholine‐induced endothelium‐dependent hyperpolarization and relaxation in rat mesenteric artery

The effects of lysophosphatidylcholine (LPC) on acetylcholine‐induced hyperpolarization and relaxation were examined in rat mesenteric arteries. LPC (3‐10 μM) reversibly inhibited endothelium‐dependent hyperpolarization by acetylcholine in a concentration‐dependent manner. LPC (10 μM) inhibited only partially endothelium‐dependent relaxation by acetylcholine. However, acetylcholine‐induced relaxation obtained in the presence of 100 μM NG‐nitro‐L‐arginine was almost completely eliminated by 10 μ LPC. These results indicate that LPC inhibits hyperpolarization and relaxation due to endothelium‐derived hyperpolarizing factor more specifically than the relaxation due to endothelium‐derived nitric oxide.