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Comparative activity of ilmetropium iodide and other anticholinergic drugs

Ilmetropium iodide selectively blocks M-cholinergic receptors of bronchial muscle, reduces or prevents bronchoconstrictor response associated with both cholinergic stimulation, as well as the impact of the factors that provoke bronchospasm (cold air, the smell of chlorine, tobacco smoke, exercise, etc.). The aim of the study was to evaluate comparative activity of ilmetropium iodide and other anticholinergic drugs in vivo model - acetylcholine-induced bronchoconstriction in anesthetized guinea pigs. Tracheal muscle contractions were recorded using laboratory equipment - basic recording station connected to the sensor bronchospasm (Ugo Basil). Protective effect of anticholinergic drugs on acetylcholine action on isolated guinea pig organs was estimate in vitro. Results and discusion: Strength and selectivity of ilmetropium iodide action substantially exceeds atropine sulfate and ipratropium bromide (Table 1). Atropine sulfate activity is equal to one. Relative activity of Ipratropium bromide is 3.9 and ilmetropium iodide is 10.0. The dose causing a 50% decrease of the acetylcholine-induced bronchoconstriction was the lowest for ilmetropium iodide - 0.45±0.13 µg/kg.
 * atropine sulfate activity is equal to one Conclusion: The potency and selectivity of ilmetropium iodide substantially exceeds that of atropine sulfate and ipratropium bromide.