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Myenteric neuroprotective role of aspirin in acute and chronic experimental infections with Trypanosoma cruzi

Experimental and clinical studies have shown that myenteric neuron cell death during infection with Trypanosoma cruzi mainly occurs in the esophagus and colon, resulting in megaesophagus and megacolon, respectively. Evidence suggests that the cyclooxygenase enzyme (COX) is involved in the T. cruzi invasion process. The use of low‐dose aspirin (ASA), a COX‐1/COX‐2 inhibitor, has been shown to reduce infection with T. cruzi. Therefore, in this study, we evaluated the effects of treatment with low‐dose ASA on myenteric colonic neurons during murine infection with T. cruzi.