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[Initial treatment of multiple myeloma].

Melphalan and prednisone are still considered the "gold standard" in the treatment of multiple myeloma. In the submitted paper the authors review randomized studies which evaluate the contribution of polychemotherapy in this disease. Polychemotherapy induces a major number of therapeutic responses and its onset is more rapid. However, as regards the survival period the groups treated by standard therapy and polychemotherapy do not differ significantly.