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One-way ticket to the cell pole: Plasmid transport by the prokaryotic tubulin homolog TubZ

Each cell faces many challenges during its life cycle. One of the most crucial is ensuring that its genetic patrimony is accurately passed on to daughter cells. In bacteria, the most well-dissected DNA segregation mechanisms are those specified by low-copy-number plasmids. Whereas high-copy-number plasmids rely on passive diffusion for their distribution at cell division, low-copy-number plasmids require specialized mechanisms. To this end, they encode a “survival tool kit” enabling them to be delivered to and partitioned into daughter cells.