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Muscle changes during reinnervation after repeated nerve injuries.

Localized freezings of adult rat sciatic nerve, repeated 2 to 5 times at monthly intervals, induced a series of profound changes in the gastrocnemius muscle. In particular, many type IIC fibres were observed one month after the last freezing. However, this muscle transformation was not stable. Our combined cytological, cytochemical and electrophysiological results provide evidence for multiple and polyneuronal innervation of these type IIC fibres.