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Renal Structure‐Function Relationship in the Obese ZSF1 Rat Model of Diabetic Nephropathy

Although the obese ZSF1 rat is a preclinical model of type 2 diabetic nephropathy (DN) with marked renal dysfunction and structural derangement, the course of disease progression has not been evaluated in an age‐dependent manner. This study characterizes temporal changes in renal function relative to changes in proteinuria and glomerular and tubulointerstitial structure to further understand renal disease progression in this model.