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Clinicopathologic profile of extranodal follicular dendritic cell sarcoma in the mesentery of small intestine: a study of two cases with literature review.

AIM
To analyze the clinicopathologic profile of the extranodal follicular dendritic cell sarcoma (FDCS) in the mesentery of small intestine.


MATERIALS AND METHODS
The clinical observations and histopathologic andimmunohistochemical features of FDCS were analyzed in the mesentery of small intestine.


RESULTS
FDCS had no characteristic clinical manifestations. Histology showed oval sarcoma cells forming fascicles of spindle cells and whorls. Sarcoma tissue was distributed pervasively and often mixed with some T lymphoid cells. Immunohistochemical markers showed the follicular dendritic sarcoma cells were positive for CD21, CD23, CD35, D2-40 and vimentin, and weakly positive for CD68, and S-100, while EMA, CD1a, desmin, AE1/AE3, CD45RO, CD3, LCA and MPO were negative.


CONCLUSION
FDCS is a rare malignant tumor in the mesentery of small intestine.I Its diagnosis depends on the histopathology and immunohistochemical staining, and its prognosis is uncertain. Surgical operation is the first choice of treatment.