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Hapten-carrier relationships in the production of rat homocytotropic antibodies.


 Various hapten-protein conjugates have been used to elicit the production of antibodies involved in immediate-type hypersensitivity reactions in immediate-type hypersensitivity reactions in guinea pigs (1, 2), mice (3), rats (4, 5) and man (6). In the guinea pig, the concentration, the relative proportions of γ1 and γ2 and the average intrinsic association constant of anti-2,4-dinitrophenyl (DNP) antibodies were shown to depend on the nature of the carrier molecule used for immunization (7). Soluble extracts derived from Ascaris suum injected in association with B. pertussis vaccine elicited high titers of homocytotropic (Hc) antibodies in the rat; compared with hemocyanin and ovalbumin, 10 times less Ascaris antigen was required to induce detectable levels of Hc antibodies (8). The present report deals with the production of rat Hc antibodies to three different dinitrophenyl-carrier conjugates. The results will show that both anti-DNP and anti-carrier antibody titers obtained in rats immunized with a DNP-Ascaris conjugate were significantly higher than those obtained against DNP-hemocyanin or against DNP-bovine gamma globulin.