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IDDF2020-ABS-0159 A new diagnostic index of skeletal muscle mass for predicting short-term postoperative complications in Crohn’s disease

Background Skeletal muscle depletion has been suggested to affect postoperative complications in surgical patients. The creatinine-to-cystatin C ratio (CCR) is demonstrated as a new marker of muscle mass. The present study investigated the role of CCR in predicting postoperative complications in Crohn’s disease (CD). Methods This cohort study included 344 CD patients undergoing bowel resection from January 2016 to June 2019 at the Inflammatory Bowel Disease Center, Sir Run Run Shaw Hospital. Univariate and multivariate analyses were performed to identify risk factors for postoperative complications in CD. Receiver operating characteristic (ROC) curves were developed to examine the cutoff value of predictors in postoperative complications. Results Among all the patients, 120 (34.9%) had postoperative complications and 224 (65.1%) recovered uneventfully. Preoperative albumin, C-reactive protein, white blood cell, creatinine, cystatin C, CCR, operative time, surgical history, laparoscopy, estimated blood loss, azathioprine and corticosteroids usage, and enteral nutrition were demonstrated to predict postoperative complications in CD (all p value Conclusions CCR was a simple and useful predictor as evaluating skeletal muscle mass to identify patients with a high incidence of postoperative complications in CD.