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Cord Blood Allergen-Specific IgE Is Associated With Reduced IFN-γ Production by Cord Blood Cells: The Protection Against Allergy–Study in Rural Environments (PASTURE) Study

Pfefferle PI, Sel S, Ege MJ, et al; PASTURE Study Group. J Allergy Clin Immunol . 2008;122(4):711–716

PURPOSE OF THE STUDY. To investigate the relationship between allergen-specific cord blood (CB) immunoglobulin E (IgE) levels, parental allergen sensitization, CB cytokine production, and environmental influences.

STUDY POPULATION. This study included families recruited for the multicenter Protection Against Allergy–Study in Rural Environments (PASTURE) study, an ongoing longitudinal birth cohort study designed to evaluate risk factors and preventative factors for atopic disease. Pregnant women in their third trimester were recruited for participation from Finland, Germany, France, Switzerland, and Austria.

METHODS. CB samples were collected from umbilical cord veins, and parental blood …