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Restenosis: the mouse that roared.

No development in interventional cardiology has created a stir like the drug-eluting stent for preventing restenosis. The attention of the medical community, the press, and the public has been intense and rightfully so, because restenosis has been the bane of interventional cardiology for the past 25 years. As we cardiologists celebrate the potential demise of our nemesis restenosis, we should also be honest in assessing how serious a villain he currently is.