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Excess maternal transmission and familial aggregation of Type 2 diabetes in Sri Lanka

Introduction : An excess of maternal transmission of Type 2 diabetes mellitus has been reported in Europid populations, but not in South India. Method : A questionnaire-based survey was carried out in 1000 (502 male) people with Type 2 diabetes to establish whether there is an excess of maternal transmission and familial aggregation in a Sri Lankan population. Results : Mean age of onset was 479 /12 (9 /S.D.) years and duration of diabetes was 99 /7 years. Thirty-seven percent reported parents with diabetes, 46.9% had no parents with diabetes, 16.1% did not know the diabetes status of at least one parent and there was no diabetes in the other. Of the probands, 59.4% had at least one affected relative. When both parents’ diabetes status was known and only one was affected, diabetes was more common among mothers (n/156) than fathers (n/125) of probands (P B/0.001). A further 54 probands had both parents with diabetes. Mean age of onset and duration of the disease among probands with parental diabetes was 43.19 /(11.1) and 9.69 /(6.8). In the previous generation, 21.2% of maternal grandmothers and 17.3% of maternal grandfathers in the maternal diabetes group and 4.8% of maternal grandmothers and 17% of maternal grandfathers in the paternal diabetes group had diabetes. Diabetes in siblings and children was more common in those with mothers who had diabetes (53.8% and 4.5%) when compared with those in whom fathers had diabetes (42.4% and 1.6%) (P B/0.0001 and P B/ 0.01). Conclusion : Familial aggregation and excess maternal transmission were observed in people with Type 2 diabetes in Sri Lanka. # 2002 Elsevier Science Ireland Ltd. All rights reserved.