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Gold nanopyramidal plasmonic crystals for label-free biosensing

We developed a wafer-scale 3D plasmonic crystal consisting of gold nanopyramid arrays using a colloidal templating technique. These surface plasmons in the arrays allow us to obtain real-time, label-free and high sensitivity biomolecular binding measurements. In our research, we found the sensing capabilities improved while the detection limit of the alcohol dehydrogenase sensing was down to pM. The features of low cost fabrication and real-time, label-free, specific and quantitative measurement capabilities suggest promise for the gold nanopyramid arrays in both biological and chemically based analytical detection systems.