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Experimental study on the comparative thrombolytic effects of intracoronary and intravenous administration of urokinase.

The effects of intracoronary (i.c.) and intravenous (i.v.) or intraventricular (i.vt.) urokinase (UK) administration were studied in a canine experimental model in which a coronary thrombus was produced by a modified electrical stimulation method. The success rate of coronary thrombolysis was 77% (17/22) with i.c. administration of 4,000 U/Kg of UK. Either i.v. or i.vt. UK administration of less than 24,000 U/Kg induced thrombolysis in 25% (2/8), while i.v. administration of more than 25,000 U/Kg resulted in a success rate of 64% (7/11) with a fibrinogen reduction from 313 +/- 63 mg/dl to 116 +/- 34 mg/dl.