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FTIR ANALYSIS OF PLASMA COQ 10 IN ATORVOSTATIN TREATED HYPERLIPIDAEMIA PATIENTS WITH MYOPATHY

Hypercholesterolemia is one of the leading causes of death and disability in the worldwide. Statins (HMG- CoA reductase inhibitors) are medications at the forefront of the battle against cardiovascular disease. Despite their effectiveness, patient compliance with statins has lagged because of adverse effects, namely myalgia, myopathy and rhabdomyolysis. Myopathy is the most common side effect of statin use. The purpose of this study is to report plasma levels of CoQ10 in patients taking statins and then to determine the benefit of Coenzyme Q10 (CoQ10) supplementation on statin-related myopathy as evidenced by symptomatic improvement and increase in serum levels of CoQ10. Key words Hypercholesterolemia, statins, myalgia, myopathy, rhabdomyolysis, CoQ10