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Evaluation of the antidiabetic activity of leaves extract of Careyaarborea

Aim: To evaluate the antidiabetic activity of methanolic extract of Careyaarborea leaves Methods: Antidiabetic activity of methanol extract of Careyaarborea leaves was investigated using alloxan-induced diabetic rat model. Results: Effect of MECAL on blood glucose level. The antidiabetic activity of MECAL was studied in alloxan mediated diabetic rats. Administration of alloxan at a dose of 120 mg/kg caused hyperglycemia as compared to the normal control group. The treatment with graded doses (250 and 500 mg/kg) of the test extract on the 7th and 14th day showed a significant fall in elevated blood glucose levels as compared to that of diabetic control rats in a dose-dependent pattern. The reference standard drug glibenclamide exhibited significant anti-diabetic activity. The results of the test extract were found to be less potent than that of the standard drug. Effect of MECAL on serum lipids and creatinine The alloxan exposure in rats significantly elevated the levels of serum cholesterol, triglyceride and creatinine when compared to normal control rats. There was a marked decrease in elevated levels of these biochemicals monitored in animals treated with graded doses of MECAL for 14 days when compared to diabetic control rats. The standard drug glibenclamide significantly reversed the altered concentrations of these biochemicals. Conclusion: In conclusion, the methanolic extract of Careyaarborea leaves exhibited dose-dependent significant antidiabetic property against alloxan-induced diabetic rats.