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Gastrointestinal presentation of Langerhans cell histiocytosis in a child with perianal skin tags: a case report.

Langerhans cell histiocytosis (LCH) is caused by a clonal proliferation of Langerhans cells. The condition can present as solitary bone lesions or as a systemic disorder with a wide clinical spectrum. The gastrointestinal tract is usually involved as part of a generalized disease, and only occasional cases with isolated gastrointestinal involvement are reported. Bleeding may be the presenting gastrointestinal complaint in LCH, but the gastrointestinal signs and symptoms often are entirely nonspecific. An increased awareness of the various presentations and symptomatology of LCH may help with the earlier detection of this lesion in the absence of typical bone and cutaneous findings. We report a child with LCH that mainly involved the oral cavity and gastrointestinal tract, including the perianal skin.