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Elevated urinary excretion of endothelin in insulin‐dependent diabetes mellitus: no influence of physical exercise

The urinary excretion of endothelin was measured by radioimmunoassay in children with diabetes mellitus in metabolically stable condition before and after ergometric exercise. Apparently healthy children served as normal controls. The excretion of endothelin, calculated for 24 h and the ratio of endothelin/creatinine in urine were also significantly higher in diabetic children compared to normal controls. Physical exercise had no influence on renal endothelin excretion. In diabetic children the volume of diuresis was higher compared to controls. Physical exercise had no influence on diuresis. In a previous study we found a positive correlation between diureses and endothelin excretion. Therefore, the increased endothelin excretion in the diabetic patients may be at least partially the consequence of the higher diuresis values. It cannot be excluded, however, that it may be a sign of altered renal function as well. Furthermore, the present study suggests that in patients with diabetes mellitus elevated sympathetic nerve activity as a result of physical activity does not influence renal endothelin production.