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Urease tests for Campylobacter pylori: care in interpretation.

Campylobacter pylori is associated with the presence of histological gastritis' yet its role in the pathogenesis of peptic ulcer disease and non-ulcer dyspepsia remains unclear. Detection of C pylori in antral or duodenal biopsy specimens usually entails histological or microbiological methods that may take up to seven days. The unusual characteristic of rapid urea hydrolysis by C pylori, indicating the presence of preformed urease, has been well described. There are now several reports of rapid urease testing (RUT) for the detection of C pylori, and the results of sensitivity and specificity at various incubation times are given in table 1. We have previously reported that incubation at 50C raises the sensitivity of the four hour RUT.2 The aim of this letter is to report a new method for detecting C pylori (The Middlesex Hospital CP-Test) and to compare it with currently available tests.