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Staphylococcal enterotoxins and the immune system.

Staphylococcus aureus is a versatile human pathogen capable of causing a variety of diseases ranging from relatively minor skin infections, to life-threatening conditions such as septicaemia and toxic shock syndrome. Its versatility is mirrored in the range of virulence factors that it is capable of producing (Table 1). This review will concentrate upon only one of these factors--the staphylococcal enterotoxins (SE's). Although TSST-1 and all the SE's have been purified, cloned and sequenced, (section 1.2), very little is known of their mechanism of action. The purpose of this article is to review the current state of knowledge on SE's, their interaction with the immune system and the possible consequences.