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Course of Immune Activation Markers in Patients after Severe Multiple Trauma

Severe multiple trauma is defined as an injury which affects more than one body region and the whole pattern of lesions leads to unstability of vital functions . Immune deteriora tion is frequently observed in this group of trauma patients , which usually comprises a decrease in the response to skin testing with recall antigens (1) and decreased proliferative responses to mitogens and alloantigens in \'itro (2).