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Comparative Analysis of the Corneal Response to the Fit of a Styrene‐Type Gas‐Permeable Hard (GPH) Lens

ABSTRACT This study compares, by use of a common protocol, the corneal physiological response to variations in fit of a new styrene‐type gaspermeable hard (GPH) lens to those of other contact lens materials previously studied. Each of 10 subjects was fitted with lenses in five different relations and corneal thickness change was measured by pachometry after 1, 2, and 4 hr of wear. A prediction equation was developed by multiple regression analysis which allowed the effect of fit and other factors on corneal physiological response to be evaluated. Comparison with other materials revealed the new lens offers significant physiological advantages. When optimally fitted the styrenic lens produces considerably less corneal thickness change than other GPH lenses and some soft lenses.