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Series of 50 special‐site nevi cases: Is it a unique entity or only one variant of dysplastic nevi?

In the most recent World Health Organization (WHO) book regarding skin tumors (2018), there is a chapter on special-site nevi that, in this edition, are identified as breast, axilla, scalp, ear, umbilicus, genital, and acral skin. Clinically, special-site nevi can be suspicious showing, for example, irregular borders. As they have a benign clinical course, many times they are excised for esthetic purposes. However, histopathologically, they share many features with melanoma and dysplastic nevi. Therefore, not all nevi from a special site should be considered special-site nevi. There are many studies about special-site nevi that consider only one site or anatomically specific site groups. Consequently, there is a gap regarding features of special-site nevi that could be characterized as a histopathological group. The aim of this study was to analyze the clinical and histopathological criteria of all cases of special-site nevi from one institution in order to contribute to a standardization of special-site nevi as a group.