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The role of endothelin-1 in asthma.

This review seeks to examine the potential contribution of the recently discovered peptide endothelin-1 to the pathophysiology of asthma. The actions of endothelin-1 which mimic features of asthma, the evidence for increased production of endothelin-1 in asthma and the potential for asthma therapy based on modification of the activity of endothelin-1 are reviewed.