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Fibrocartilaginous mesenchymoma of bone: a single‐institution experience with molecular investigations and a review of the literature

Fibrocartilaginous mesenchymoma is a rare intraosseous lesion, with a total of 26 cases described in the literature. This study describes the clinical, radiological and histological features of eight new cases of fibrocartilaginous mesenchymoma collected at a single institution between 1982 and 2016. The presence of GNAS and IDH1/2 mutations and MDM2 amplification was explored to evaluate possible links between fibrocartilaginous mesenchymoma, fibrous dysplasia, de‐differentiated chondrosarcoma and low‐grade osteosarcoma.