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Urinary catecholamines and their metabolites in diabetes.

Total, free, and conjugated urinary catecholamines and their metabolites are studied in diabetes before and after treatment. There are abnormalities in catecholamines metabolism and their metabolites caused by the diabetic condition. The 24 hour urinary excretion of the total catecholamines is significantly increased in diabetics. Epinephrine, as a free fraction, conjugated fraction, and, consequently, as a total metabolite, is significantly increased. No change in dopamine concentration is observed in diabetes although dopamine is known to inhibit insuline release. No sex difference is, however, observed in the diabetic patients with regards to the catecholamines excretion. After controlling the diabetic state, abnormalities in catecholamine metabolism and their metabolites are normalized.