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Paranasal Sinus Leiomyosarcoma after Cyclophosphamide and Irradiation

Leiomyosarcoma is a rare complication of radiation and cyclophosphamide therapy. Paranasal leiomyosarcoma complicating irradiation and cyclophosphamide therapy in a 66-year-old man with a history of destructive nasoantral process is presented. This case highlights the difficult differential diagnosis. both clinically and histopathologically, in destructive lesions of the midface. The occurrence of rare induced second malignancies after irradiation or certain antineoplastic agents emphasizes the need for specific diagnosis .