{'fraction_non_alphanumeric': 0.018542475204829666, 'fraction_numerical': 0.0017248814144027599, 'mean_word_length': 5.4804469273743015, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Photodynamic therapy with methyl aminolaevulinate for cervical and/or facial lesions of folliculotropic mycosis fungoides: interest and limits

+CD56+ NK cells are significantly decreased in patients with psoriasis compared with healthy controls. Indeed, it is important to study homogeneous groups with regard to age and sex, as these parameters may affect the quantity and quality of circulating lymphocytes such as NK cells and B lymphocytes. The mechanisms leading to a decrease of circulating NK cells in patients with psoriasis could be due to chemokine-dependent NK cell recruitment from the periphery to the inflamed skin. Alternatively, the reduction of NK cell frequency in patients with psoriasis could be due to an impaired cell survival, consequent to chronic (systemic) inflammatory conditions or to pharmacological treatments. A limitation of the present study is that we could not correlate NK and B cells with psoriasis severity, which might have an impact on the circulating lymphocyte count. We found that circulating B lymphocytes are significantly increased in patients with psoriasis. Although B cells have sporadically been described in psoriatic lesions – particularly in patients with psoriatic arthritis – to date, increased absolute counts and percentages of circulating B lymphocytes have not been documented. However, we have recently observed that as well as T lymphocytes, B cells are also significantly reduced under a course of treatment with fumaric acid esters, indicating for this lymphocyte subset a possible pathogenetic role in psoriasis. Following CD20 B lymphocyte antibody therapy, Jimenez-Boj et al. and Chang et al. recently observed a significant improvement of psoriatic arthritis and palmoplantar pustulosis, respectively. Interestingly, an expansion of circulating B cells has been demonstrated in some other autoimmune diseases, including rheumatoid arthritis, Sjögren’s syndrome, and even in cutaneous lupus erythematosus. In conclusion, it has been suggested that NK cells, NKT cells and B lymphocytes play a role in the pathogenesis of many autoimmune diseases. Hence, the significant alterations of circulating NK and B cell counts and percentages observed in the present study indicate a possible pathogenetic role for these lymphocyte subsets in psoriasis as well.