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Ultrahigh sensitivity SERS detection of DNA and protein translocating through a plasmonic nanopores

The SERS-based detection of DNA and protein sequences with single nucleotide or amino acid sensitivity still represent a huge challenge. Recently, a new method based on the trapping of a gold nanoparticle in a plasmonic nanohole has been demonstrated. The plasmonic platform obtained by the combination of a nanoparticle trapped inside a nanopore enables to generate a single SERS hot spot for single-molecule detection with a spatial resolution high enough to resolve single element within a biomolecule. The superior spectral and spatial resolution of this approach can be applied to single DNA molecule and single-protein analysis, fingerprinting, and sequencing.