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Natural antibody against Thomsen-Friedenreich antigen in sera of patients with carcinomas and infectious diseases.

The levels of natural antibody against Thomsen-Friedenreich (TF) antigen in sera of patients with various cancers and infectious diseases were examined by an enzyme-linked immunosorbent assay (ELISA) and compared with those of healthy donors. The levels of antibody against TF antigen in sera of patients with adenocarcinomas such as gastric, pancreatic and colorectal cancers were lower than those of patients with hepatoma, pyelonephritis and pneumonia. These findings may reflect the expression of TF-antigen in adenocarcinoma tissues.