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Crossed and uncrossed projections to the cat sacrocaudal spinal cord: III. Axons expressing calcitonin gene‐related peptide immunoreactivity

We have investigated the projection patterns of peptidergic small‐diameter primary afferent fibers to the cat sacrocaudal spinal cord, a region associated with midline structures of the lower urogenital system and of the tail. Calcitonin gene‐related peptide (CGRP)‐immunoreactive (CGRP‐IR) primary afferent fibers were observed within the superficial laminae, rostrally as the typical inverted U‐shaped band that capped the separate dorsal horns (S1 to rostral S2) and caudally as a broad band that spanned the entire mediolateral extent of the fused dorsal horns (caudal S2 and caudal). Within the dorsal gray commissure, labeling was seen as a periodic vertical, midline band. CGRP‐IR labeling was prevalent in an extensive mediolateral distribution at the base of the dorsal horn, originating from both lateral and medial collateral bundles that extend from the superficial dorsal horn. Some bundles, in part traveling within the dorsal commissure, conspicuously crossed the midline. In addition to the robust projection to the superficial dorsal horn, there was a more extensive distribution of CGRP‐IR fibers within the deeper portions of the cat sacrocaudal dorsal horn than has been reported for other regions of the cat spinal cord. Presumably, these deep projections convey visceral information to projection or segmental neurons at the neck of the dorsal horn and in the region of the central canal. This deep distribution overlaps the reported projections of the pelvic and pudendal nerves. In addition, the contralateral projections of CGRP‐IR fibers may form an anatomical substrate of the bilateral receptive fields for selective dorsal horn neurons. The density and variety of CGRP‐IR projection patterns is a reflection of the functional attributes of the innervated structures. J. Comp Neurol. 438:388–398, 2001. © 2001 Wiley‐Liss, Inc.