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A15453 Maternal voluntary exercise during pregnancy regulates cardiometabolic age-related risk factors and telomere length in heart ventricles of adult rat offspring

Objectives: Telomeres length (TL) is considered a biomarker of biological ageing and its shortening has been associated with age-related diseases such as cardiovascular diseases and increase mortality. Exercise known to reduce risk of heart diseases and also protect the telomeres integrity. The objectives of this study was to investigate the effects of voluntary exercise during pregnancy on cardiometabolic risk factor, heart ventricle (HTV) size and TL in adult offspring. Methods: Female Sprague-Dawley rats were fed chow (C n = 28) and from ten days before mating until parturition. Half were allowed access to a running wheel (CE) in the home cage; the others remained sedentary (CS). Offspring were weaned on chow diets and remained sedentary. Mothers were killed at postpartum week 4. Two offspring from each mother were killed at 13 weeks of age and HTV were dissected. TL and gene expression of telomerase markers were investigated by RT-PCR. Results: Mothers showed a modest level of exercise. Exercised mothers have longer telomere length in compare to sedentary. Male offspring from exercised mothers had significantly lower body weight, fat mass, blood glucose and HVT size when adjusted with tibia length. Maternal exercise significantly increased Telomere length in both male and female offspring. TL related genes (TERC (telomerase RNA component), TERT (telomerase reverse transcriptase) and PNUTS (PPP1R10) were increased in female and TERC in male offspring of exercised mothers. Male offspring (CE) had reduced level of TNF-alpha in HVT compared to control. Conclusion: Modest levels of maternal exercise appeared to increased TL and genes expression related to protect TL in HVT of offspring. Exercise had sex specific benefits that were observed in phenotype, HVT size and in genes expression.