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Involvement of miR-454 overexpression in the poor prognosis of hepatocellular carcinoma.

OBJECTIVE
Many studies informed that microRNAs (miRNAs) could function as diagnostic and prognostic indicators in several cancers. The prognostic value of miR-454 in hepatocellular carcinoma has not been investigated.


PATIENTS AND METHODS
A total of 265 patients with HCC were obtained in this retrospective study between June 2009 and July 2014. qPCR was conducted to evaluate the expressed amount of the miR-454. The Kaplan-Meier method was conducted to explore the survival status of HCC patients. The log-rank test was used to analyze differences in survival rates.


RESULTS
The expression of miR-454 was significantly upregulated in HCC tissues compared with adjacent non-cancerous tissues (p < 0.001). High levels of miR-454 in HCC tissues were correlated with a low 5-year overall survival (OS) (p < 0.001). Moreover, patients with high miR-454 expression had decreased disease-free survival (DFS) (p < 0.001). Furthermore, multivariate analysis showed that up-regulation of miR-454 was an independent prognostic factor for both 5-year OS (p = 0.013) and 5-year DFS (p = 0.008).


CONCLUSIONS
We firstly prove that expression of miR-454 may be a novel and valuable prognostic factor in HCC.