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45Calcium Uptake During the Transition from Reversible to Irreversible Liver Injury Induced by D‐Galactosamine In Vivo

The hepatic uptake of45calcium (45Ca) was studied in rats after administration of D‐galactosamine (3 mmoles per kg, i.v.). In contrast to measurements of the hepatic calcium content, 45Ca uptake served as a dynamic rather than a static indicator of calcium homeostasis during the transition from reversible to irreversible liver injury which occurs between 3 and 4 hr after injection of the hepatotoxin. 45Ca uptake during a 1 hr‐labeling period increased from 25 to 100% above control between 3 and 4 hr and subsequently remained at this level.