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EFFECTS OF LITHIUM TREATMENT IN VITRO AND IN VIVO ON ACETYLCHOLINE METABOLISM IN RAT BRAIN

Abstract— The effects of LiCl on cholinergic function in rat brain in vitro and in vivo have been investigated. The high affinity transport of choline and the synthesis of acetylcholine in synaptosomes were reduced when part (25‐75%) of the NaCl in the buffer was replaced with LiCl or sucrose. This appeared to be due to lack of Na+ rather than to Li+, as addition of LiCl to normal buffer had little effect.