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Medical management and visual rehabilitation of limbal niche dysfunction.

Limbal niche dysfunction (LND) has been described as a medically reversible form of limbal stem cell deficiency. The current literature is sparse regarding therapeutic options to improve visual function after stabilization of the disease. A 61-year-old monocular woman with an extensive medical and ocular history presented with long-standing recalcitrant epitheliopathy in both eyes. History and examination findings on presentation led to a diagnosis of LND, and medical therapy was initiated. After 8 months, her ocular surface had improved and corrected distance visual acuity (CDVA) was 20/40. She was fit with a scleral contact lens because of its ability to promote ocular surface healing and improve visual acuity. She maintained symptom resolution and her CDVA improved to 20/20. LND is a distinctive and reversible epitheliopathy that responds favorably to appropriate medical therapy. To the authors' knowledge, this is the first reported case of using the scleral contact lens as an adjunctive visual rehabilitation therapy to complement medical treatment for LND.