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Active T and EA-rosette-forming cells in human cadaver renal allograft recipients.

Active T(AT) and EA-rosette-forming cells (RFC) were determined in seventeen haemodialysis patients and twenty-two renal allograft recipients to correlate these estimates with the clinical outcome of renal allografts. Either AT- or EA-RFC or both were found to be elevated during the period of rejection crisis. Assays for AT- and EA-RFC were found to be complementary suggesting that they may be detecting two different types of rejection crises. Thus, determination of AT- and EA-RFC in the peripheral blood may prove to be useful in the routine immunological monitoring of renal allograft recipients.