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Brain‐derived neurotrophic factor is elevated in the blood serum of Crohn's disease patients, but is not influenced by anti‐TNF‐α treatment—A pilot study

Brain‐derived neurotrophic factor (BDNF) is associated with depression, pain, or sleep disorders, factors that are thought to be involved in the pathogenesis and clinical course of Crohn's disease (CD). Therefore, the study aimed at assessing the BDNF serum level in patients with CD and evaluates the effect of anti‐TNF‐α therapy on the BDNF level and its impact on sleep, mood, and pain parameters.