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Differential Impacts of Adiponectin on Low‐Grade Albuminuria Between Obese and Nonobese Persons Without Diabetes

The goal of this study was to examine the association between adiponectin and low‐grade albuminuria in nondiabetic persons and whether it differed between obese and nonobese individuals. Urinary albumin excretion (UAE) was assessed by overnight collection in 157 participants. Overall, as anticipated, 24‐hour systolic blood pressure and fasting glucose levels were independent determinants of UAE (β=0.254 and 0.176, respectively, P<.05). In obese persons (body mass index [BMI] ≥25 kg/m2; n=63), adiponectin value was a significant negative determinant of UAE (β=−0.256, P<.05) independent of blood pressure and glucose levels, whereas in nonobese participants (n=94) it was not. In an analysis of BMI and the median value of adiponectin (9.9 µg/mL), UAE was found to be significantly higher in obese persons with low adiponectin levels than in obese persons with high adiponectin levels (9.20 vs 5.11 µg/min; P<.05), even after adjustment for age, sex, blood pressure level, and glucose level. There was an inverse association between adiponectin and low‐grade albuminuria in obese nondiabetic persons.