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Apolipoprotein E genotype, coagulation, and survival following acute stroke

Article abstract— The authors hypothesized that divergent influences of the APOE ε4 allele on ischemic and hemorrhagic stroke survival might result from differences in coagulation profiles. In 49 hemorrhagic stroke patients, ε4 carriers had higher partial thromboplastin time ratios (p < 0.01) than non-ε4 carriers. Among 529 ischemic stroke patients, increasing ε4 allele dose was associated with improved survival (p = 0.03) after adjusting for baseline NIH stroke scale (p = 0.00001) and partial thromboplastin time ratio (p = 0.01). Relative anticoagulation does not fully explain the survival advantage in ε4-carrying ischemic stroke patients.