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Identifying novel causal genes and proteins in Alzheimer’s disease

Recent large‐scale proteomic analyses have shown Alzheimer’s disease (AD) phenotypes (i.e., clinical manifestations of AD or AD pathology) to correlate with expression levels of hundreds of proteins in brain. However, it is currently unknown whether variation in these protein levels are causes or consequences of AD. Here, we use mediation analysis to identify brain proteins that are under genetic control and play a causal role in AD.