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Immunoadjuvant activity of bacterial fractions on antibody-forming cells during the primary immune response period.

The adjuvant activities of Bordetella pertussis methanol-soluble fraction (MSF-MB) and methanol extraction residue (MER-MB) of Mycobacterium butyricum, and methanol extraction residue of M. bovis BCG strain, (MER-BCG), on the primary immune response in rats were compared by determining the antibody-forming cell (AFC) number and the hemagglutinin titer on days 2 to 6 after sheep erythrocyte (SRBC) injection. All adjuvants induced splenic hyperplasia and AFC multiplication which, in turn, effected a heightened hemagglutinin response; however, the time for this effect to appear following antigenic stimulation varied with the adjuvant. Treatment with B. pertussis significantly enhanced the AFC number only on day 5 post-SRBC immunization with a significant increase in hemagglutinin level becoming apparent on the same day (day 5). Treatment with MSF-MB not only enhanced the AFC number, but also induced this effect more rapidly; significantly greater numbers of AFC appeared as early as day 3 post-SRBC immunizati...