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Hypothalamo‐Vagal Oxytocinergic Neurocircuits Modulate Gastric Emptying And Motility Following Stress

Stress triggers and exacerbates the symptoms of functional gastrointestinal (GI) disorders, such as delayed gastric emptying and impaired gastric motility. The prototypical anti‐stress hormone, oxytocin (OXT), modulates GI tone and motility via vagal pathways. Following acute or chronic stress, the oxytocinergic neurocircuits from the hypothalamus to brainstem neurons of the dorsal vagal complex (DVC) undergo neuroplasticity. However, the physiological role of this neuroplasticity in modulating gastric functions following stress is yet unclear. In this study, we used chemogenetic technology to test the hypothesis that activation of hypothalamo‐vagal oxytocinergic neurocircuits plays a pivotal role in the modulation of gastric emptying and motility following stress.