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Myocardial nutritional circulation in rabbits after doxorubicin injection.

The effect of doxorubicin on myocardial nutritional circulation in rabbits was determined by means of the isotopic [133Xe] method. The drug was injected iv in doses of 1, 3, and 6 mg/kg and the influence of doxorubicin on myocardial circulation was examined 1, 15, 30, 45, and 60 min after its administration. The results indicate that a single injection of doxorubicin produces an increase in myocardial nutritional circulation.