{'fraction_non_alphanumeric': 0.05779889152810768, 'fraction_numerical': 0.04908946951702296, 'mean_word_length': 4.879069767441861, 'pattern_counts': {'":': 0, '<': 2, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Oxidised cholesterol is more hypercholesterolaemic and atherogenic than non-oxidised cholesterol in hamsters

The present study was to test the relative hypercholesterolaemic and atherogenic potency of oxidised cholesterol (OxC) and non-oxidised cholesterol in hamsters. An OxC mixture, prepared by heating pure cholesterol (100 g) at 160°C in air for 72 h, contained 78 % cholesterol and 22 % OxC. Fifty Golden Syrian hamsters were randomly divided into five groups of ten animals and fed the control diet, a 0·05 % cholesterol diet (C-0·05), a 0·10 % cholesterol diet (C-0·1), a 0·05 % OxC mixture diet (OxC-0·05) or a 0·10 % OxC mixture diet (OxC-0·1), respectively. The OxC-0·05 and OxC-0·1 groups were more hypercholesterolaemic and had serum total cholesterol 22 and 12 % higher than the corresponding C-0·05 and C-0·1 hamsters (P < 0·05). The OxC-0·1 group demonstrated greater deposition of cholesterol and had a larger area of atherosclerotic plaque in the aorta than the corresponding C-0·1 hamsters (P < 0·05). Similarly, the aorta in the OxC-0·1 group showed greater inhibition on acetylcholine-induced relaxation compared with that in the C-0·1 hamsters. It was concluded that OxC was much more hypercholesterolaemic and atherogenic than cholesterol.