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NFAT5 Expression in Circulating PBMCs is a Potential Biomarker of Whole‐body Dehydration and Stress

Osmotic stress‐specific transcription factor NFAT5 (Nuclear Factor of Activated T cells) and heat stress‐specific factor HSF1 induce transcription of HSP70 and other protective proteins. Our previous work suggests NFAT5 as a novel cellular marker of whole‐body dehydration. We aimed to further characterize NFAT5, HSF1, and chaperone responses to progressive stress (dehydration, exercise, and heat) and recovery in humans.