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Efficacy and tolerance of doxazosin: a review.

The objective of therapy in the hypertensive patient is not the reduction of blood pressure (BP), but the prevention of coronary heart disease. Since assessment of the long-term efficacy of therapy takes many years, new antihypertensive agents are evaluated by four main criteria: predictable lowering of BP; achievement of target BP in a high proportion of patients; once daily administration; good tolerance. Comparative studies, mostly against other antihypertensive agents show that doxazosin meets all these criteria and in addition has no adverse effects on the serum lipids and may also act directly on the coronary vascular smooth muscle to inhibit the proliferative stage of atherogenesis.