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Acute Intermittent Porphyria and Inappropriate Secretion of Antidiuretic Hormone in Pregnancy

Comment Since 1869 69 cases of rupture of a splenic artery aneurysm in pregnancy or the puerperium have been reported with a maternal mortality of 72% and a foetal mortality of 97 %. Most of the aneurysms are congenital but atheromatous changes are often present. Rupture occurs most commonly in the last trimester and prolonged hypertension may be a contributory factor. No case of syphilis has been recorded before and only one other twin pregnancy.