{'fraction_non_alphanumeric': 0.053203040173724216, 'fraction_numerical': 0.016286644951140065, 'mean_word_length': 5.585714285714285, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Synthesis and Antimicrobial Evaluation of Pyrazole-4-carboxamide Derivatives

Microbial resistance to the clinically employed antibiotics becomes a threat to the treatment protocols
of microbial infectious diseases. Current work aims to synthesize a novel series of pyrazole-4-
carboxamide derivatives (6a-j) in a multicomponent reaction between 1H-pyrazole-4-cabaldehyde
and various substituted anilines in the presence of 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene
(iPr)/TEMPO/phenol under oxidative amidation condition. All the synthesized derivatives (6a-j) were
examined for their antifungal and antibacterial activities. All compounds (6a-j) showed significant
antimicrobial potential against Gram-positive bacteria (B. subtilis and S. aureus), Gram-negative bacteria
(E. coli and P. seruginosa) and fungal strains (A. niger and C. albicans). Compounds 6a, 6f and 6g
exhibited better antimicrobial activities.