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The effect of carisoprodol on performance on repeatedly administered neuropsychological tests

The present double‐blind experiment investigated whether the muscle relaxant carisoprodol affected performance on three neuropsychological tests. Our results showed no effect of carisoprodol on test scores, suggesting no cerebral affection of carisoprodol in humans. There were no changes in skin conductance responses after carisoprodol administration, indicating that the arousal level was not affected. However, there was significant improvement in test scores across days for all tests, indicating that test scores improved with practice. © 1997 John Wiley & Sons, Ltd.