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Relationship between body‐mass index and serum folate concentrations in pregnant women: Mothers and Children′s Environmental Health (MOCEH)

There is scientific evidence of a negative association between body mass index (BMI) and concentration of the micronutrients known to be important for pregnancy outcome. The micronutrients status in overweight or obese pregnant women has been largely neglected, despite the rates of pregnancy complications and fetal malformation being high in these women. We evaluated the association between BMI and serum folate concentrations in Korean pregnant women. Existing serum folate values were analyzed together with dietary folate intake data based on BMI quartiles at two time points (mid‐ and late pregnancy; n = 802 and 660, respectively). There was a significant negative association between BMI and serum folate values at mid‐pregnancy (P‐trend = 0.001). A general linear model with covariates also indicated that there was a significant negative association between the two. It is imperative for research to focus on the micronutrient status in overweight or obese pregnant women, considering the high rate of fetal malformations among overweight or obese mothers and the rapidly increasing rate of obesity worldwide.