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Radical scavenging activity of bisbenzylisoquinoline alkaloids and traditional prophylactics against chemotherapy‐induced oral mucositis

Background and objective:  Oral mucositis is a major severe toxic side‐effect of systemic chemotherapy and irradiation in patients with cancer. Various free radical scavengers have been shown to prevent chemotherapy‐induced skin necrosis. The objective of this study was to determine the antioxidant activity of a bisbenzylisoquinoline alkaloidal compound (BIQAC) and a series of chemicals, including allopurinol, used clinically for the treatment of chemotherapy‐induced mucositis.