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Expression of glutation enzymes in splenic tissue is influenced by thiosemicarbazide derivatives

The administration of new Schiff heterocyclic bases and their copper (II) complexes, thiosemicarbazide derivatives induces various influences on the activity of glutathione-dependent enzymes in splenic tissue. The selective action of the studied compounds on the expression of glutathione enzymes is evident, which is manifested by a tendency of insignificant decrease of glutathione reductase (GR) and glutathione peroxidase (GPO), insignificant increase of glutathione-S-transferase (GST) and marked depression of glutaredoxin levels. The slight increase of GST under the action of the studied compounds can be considered as a protective reaction aimed at stagnating the intensity of peroxide processes and supporting the activity of the glutathione cycle, and decreased the activity of glutaredoxin denotes their antiproliferative, cytostatic effect. Further studies are needed to evaluate the mechanisms of action of the investigated compounds on the activity of glutathione-dependent enzymes in other biosystems and animal experiments, to assess the practical importance of the obtained results.