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Electronmicroscopic studies of parathyroid storage granules in the mouse (II) . -Effects of hypercalcemia

SUMMARY : In the mouse parathyroid chief cells fixed by perfusion with glutaraldehyde numerous secretory granules of various sizes, 100-600 nm, were dis-tinguishable from lysosomal dense bodies, because the former had a halo beneath the limiting menbrane. The number and size of all the secretory granules were measured and correlated with the mean serum calcium level (SCL). Small secretory granules less than 300 nm in diameter were rapidly decreased in number as soon as SCL lowered to 5.2±0.9 mg/dl at 10 min after an injection of 4% EDTA, whereas most of large secretory granules more than 300 nm in diameter did not decrease until the SCL dropped to 3.6±0.8 mg/dl at 20 min after the injection. On the basis of these data, it was concluded that in the mouse parathyroid, secretory granules are subdivided into two populations, small and large storage, and that the former population is easily released in responce to the decrease in SCL, but that of the latter population remains stored in the cytoplasm until the SCL becomes reduced to a certain level. In addition, it was suggested that both prosecretory and storage granules mainly originated from the trans-Golgi network.