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Influence of Different Solvent Properties and Composition for the Solubility of Iopromide

This work is to research the influence of different solvent properties and the composition on the solubility of iopromide. The solubility values of iopromide in some pure and binary solvent mixtures have been measured from T = 273.15 to 318.15 K. The result showed that the solubility obtained a maximum value in mole fraction (x = 55.426 × 10–4 at T = 318.15 K) in pure N,N-dimethylformamide (DMF) and the minimum data (x = 9.9 × 10–6 at T = 273.15 K) in neat toluene. The values in pure solvents obeyed the following order: DMF > methanol > ethanol > isopropyl alcohol > acetone > ethyl acetate > toluene. In mixed solvents, it was increased with increasing mass fraction of DMF at a given temperature. Moreover, the obtained solubility data in pure solvents were correlated with the modified Apelblat equation, and three cosolvent models (the Jouyban–Acree model, the Apelblat–Jouyban–Acree model, and CNIBS/R-K model) were applied to correlate solubility in the binary mixture. The maximum values of relative average...