{'fraction_non_alphanumeric': 0.0468417317246274, 'fraction_numerical': 0.0361958836053939, 'mean_word_length': 4.8264462809917354, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Hypothalamic - Pituitary Function in Patients with Idiopathic Growth Hormone Deficiency

The combined insulin (0.05 or 0.1 U/Kg), GnRH (100 Mg) and TRH (200 stimulation test was used to study hypothalamic-pituitary-target gland function in 58 patients with idiopathic GH deficiency and 34 children with short-stature unrelated to endocrine disorders. 79.3% of the patients with GH deficiency had abnormal secretion patterns of one or more other pituitary hormones. Altered TSH secretion was the most frequently observed abnormality occurring in 65.5% of the growth-hormone deficient patients. Failure of TSH to respond to TRH, indicating pituitary disease, was observed in four (6.9%) patients. 28 (48.2%) patients had normal basal TSH levels, but showed an exaggerated or prolonged response to TRH. Elevated basal TSH levels associated with an exaggerated response to TRH were observed in 6 (10.3%) patients, one of whom had primary hypothyroidism. Abnormalities of prolactin (PRL) secretion were present in 39.6% of the patients. Basal PRL levels were increased in 29.3% of GH deficient patients, 10.3% had a low PRL response following the combined stimulation test and In 3.4% of the patients the subnormal PRL response was associated with TSH deficiency. Abnormal Cortisol secretion was present in 37.9%. GH deficiency was associated with a single additional hormone defect in 24.1% (TSH), 8.6% (PRL), and