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[Effect of substances of a polypeptide nature isolated from the thymus and cerebral cortex on the primary immune response of mice to thymus-dependent and thymus-independent antigen].

The study of the effect of low molecular polypeptides on the primary immune response induced in CBA mice by the injection of thymus-dependent antigen (SRBC) and thymus-independent Vi-antigen showed that the injection of the preparation obtained from the cerebral cortex (cortexin) or the thymus (thymarin) for 5 days before and for 3 days after SRBc immunization stimulated the production of both direct (IgM) and indirect (IgG) antibody-producing cells, as well as the production of hemagglutinins. At the same time the production of antibody-producing cells and antibodies to Vi-antigen was suppressed. The preparations of white cerebral tissue and red bone marrow produced no effect on immune response in the animals.