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[Factors influencing survival of patients with pancreatic adenocarcinoma after surgical resection].

Objective: To investigate the clinical outcomes and prognostic factors in patients with pancreatic cancer after surgical resection with curative intent and analyze factors affecting 2-year and 5-year survival of patients. Methods: A total of 469 patients with pancreatic adenocarcinoma undergoing curative resection were included in the study, and the clinical data of these patients were analyzed retrospectively. Univariate and multivariate analyses were performed to examine factors affecting prognosis of these patients. The clinicopathological characteristics of patients who survived for ≤2 years and >2 years as well as ≤5 years and >5 years were compared, respectively. Results: The multivariate analysis showed that lymphovascular invasion (P=0.024), lymph node metastasis (P<0.001), vascular resection (P=0.002), maximum tumor diameter >2 cm (P=0.009), poor differentiation (P<0.001) were negative prognosis factors, but postoperative chemotherapy (P<0.001) was an independent positive prognostic factor. Comparison of the patients who survived for ≤2 years and >2 years showed that lymphovascular invasion (P=0.012), lymph node metastasis (P<0.001), vascular resection (P=0.014), maximum tumor diameter>2 cm (P=0.004), poor differentiation (P<0.001), peri-pancreatic fat invasion (P=0.005), absence of postoperative chemotherapy (P<0.001), advanced tumour, node and metastasis (TNM stage) (P<0.001) were associated with 2-year survival. With regard to 5-year survival, lymph node metastasis (P=0.005), poor differentiation (P=0.014) and TNM stage(P=0.025) were associated with it. Conclusions: Our results suggest that lymphovascular invasion, lymph node metastasis, vascular resection, maximum tumor diameter >2 cm, poor differentiation and absence of postoperative chemotherapy were independent negative prognostic factors. Lymph vascular invasion, lymph node metastasis, vascular resection, maximum tumor diameter >2 cm, poor differentiation, peri-pancreatic fat invasion, absence of postoperative chemotherapy, advanced TNM stage were associated with 2-year survival, and lymph node metastasis, degree of differentiation and TNM stage are important prognosis factors affecting long-term survival of patients.