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The relationship between carotid intima-media thickness and coronary atherosclerosis revisited.

Many clinical studies support the opinion that carotid intima-media thickness (IMT) assessed by B-mode ultrasound in extracranial carotid arteries, either in a single segment (common carotid) or in multiple segments (aggregate of measures in common carotids, bifurcations, and internal carotids), is a valuable mirror of coronary risk status and a worthwhile predictor of subsequent coronary heart disease (CHD), the leading source of cardiovascular death.1–3 Indeed, traditional and emerging risk factors for CHD have been found mostly to be closely correlated with increased carotid IMT.1 Also, increased carotid IMT is associated with substantially increased risk of a future CHD event in primary and secondary prevention populations.1 Thus, by analysing the proportion of subjects developing a CHD event according to the carotid IMT level at the onset of the follow-up in two pioneering prospective population-based studies,4,5 it has been shown that markedly increased IMT above ∼1 mm was associated with a 12–16% 10-year CHD incidence depending on age, sex, and carotid segment(s) measured, whereas the lowest percentiles of IMT distribution were associated with a CHD … 

*Corresponding author. Tel: +33 1 43 95 93 91; fax: 33 1 45 39 11 93. E-mail address: alain.simon{at}brs.aphp.fr