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COMPARATIVE STUDY OF HYPOGLYCEMIC AND HYPOLIPIDEMIC POTENCY OF MURRAYA KOENIGII FOR WOUND HEALING ACTIVITY IN TYPE-2 DIABETIC RATS

In the present study we examined the role of ‘Murraya koenigii’ in diabetic wound healing, whether its hypolipidemic activity plays a vital role in cytokine production, as local cytokines production fluctuate during Cutaneous wound, diabetes and in hyperlipidemia. The activity of ‘Murraya koenigii’ was compared with Pravastatin and Glibenclamide. In blood parameter study Murraya koenigii aqueous extract showed significant (p 0.05) difference for its hypoglycemic activity (decreasing fasting blood glucose level) at dose level 400mg/kg in diabetic hyperlipidemic rats when compared to the normal control group rats and in the case of its hypolipidemic activity (decreasing lipid level) it showed no significant difference at dose level 300 mg/kg only. In the excision wound model, animals treated with Murraya koenigii (200mg/kg, 300mg/kg and 400mg/kg) leaves aqueous extract showed significant reduction in period of epithelisation and wound contraction 50% when compared to the diabetic hyperlipidemic control group rats. In this wound model very significant(p<0.001) result was found with 300mg/kg dose level because the effect was dose dependent up to 300mg equivalent of extract. The groups treated with Murraya koenigii and Pravastatin showed more significant effect for excision wound healing than Glibenclamide treated group. These results clearly indicate that the hypolipidemic property of Murraya koenigii and Pravastatin may promote the epithelization and rate of wound contraction.