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Effects of the Anticancer Agent Vinorelbine on Endothelial Cell Permeability and Tissue‐factor Production in Man

Because antineoplastic drugs could increase endothelial blood barrier permeability and thrombotic diseases have been described as a complication of treatments with vinca alkaloids, the effect of a therapeutic dose (10‐8 M) of vinorelbine on transendothelial permeability was analysed by measuring the movement of albumin across a monolayer of human venous endothelial cells.