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The effect of ethanol upon early development in mice and rats. XXII. The effect of chronic consumption of nonalcoholic beer upon preimplantation development in rats.

The effect upon preimplantation development of chronic consumption of nonalcoholic beer was investigated in rats (controlled on day 5 of pregnancy) by using the following criteria: mean number of embryos/animal, oviductal-uterine migration of embryos, developmental rate and number of pathologically modified embryos. It resulted that this beverage had a noxious effect (less marked than normal beer) upon preimplantation development, manifested by the decrease of the mean number of embryos/animal and the presence of abnormal embryos. These results suggest a possible action of various congeners present in this beverage, which potentiate the noxious effect of ethanol in the case of normal beer.