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Ventilatory failure during resistive loaded breathing in the newborn primate

Previous investigations have shown that ventilatory failure during severe inspiratory resistive loading (IRL) in the 21‐day‐old infant primate occurs secondary to a decrease in respiratory frequency, that is, central failure. To examine the response of the more immature newborn to IRL, minute ventilation (V′E), arterial blood gases and pH, minute diaphragmatic electromyogram (EMG) activity, peak inspiratory airway pressure, and the centroid frequency (Fc) of the diaphragmatic EMG power spectrum were measured in four unanesthetized tracheotomized 2‐day‐old monkeys during various levels of IRL, until either (1) ventilatory failure occurred (ventilatory failure run) or (2) normocapnia was sustained for 1 hr (successful trial).