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Evaluation and comparison of in vitro and in vivo degradation kinetics of magnesium

It is necessary to understand the fundamental degradation mechanism of magnesium in physiological solutions and to establish test procedures that are closely mimicking the in vivo conditions. To examine the influence of the cellular metabolism on magnesium degradation, pure magnesium samples were incubated in fresh and in used cell culture medium that was collected as supernatant after culturing with fibroblast cells. Magnesium wires were incubated in vitro and the degradation compared to subcutaneous implants in mice and to implants in the tail artery.