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Effects of serum lipoproteins on damage to erythrocytes and Candida albicans cells by polyene antibiotics.

Polyene antibiotics can be classified into two major groups based on the size of their macrolide rings [1, 2]. The large polyenes, of which amphotericin B is an example, have seven conjugated double bonds (heptaene), whereas the small polyenes contain fewer than seven double bonds. Nystatin is structurally similar to amphotericin B except that it has four conjugated double bonds and two conjugated bonds separated from the four by a methylene bridge. It has been classified as a large polyene along with amphotericin B [1, 2]. A number of biologic properties distinguish the large polyenes from the small, including the relation between their permeabilizing and lytic actions on cells [1-3]. Here we extend our study of the interactions of lipoproteins with amphotericin B [4] to other polyenes.