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Cutaneous Gamna‐Gandy bodies: An unusual case of dystrophic calcification

Dystrophic calcification is a common histopathologic finding that can be concomitant with a plethora of diseases, ranging from self‐limited infections to insidious malignancies. Gamna‐Gandy bodies (GGBs) are a form of dystrophic calcification associated with chronic hemolysis and are typically observed in the spleen. In this report, we present the case of a 92‐year‐old man who presented with a 4‐mm blue papule that was biopsied given the concern for a blue nevus. The subsequent histopathologic examination of the biopsy specimen showed a dermal organizing hematoma adjacent to pale‐yellow to brown, refractile material within fibrotic collagen consistent with GGBs. Scanning electron microscopy with energy‐dispersive x‐ray analysis (SEM/EDXA) revealed that the structures were composed of carbon (39%), oxygen (32%), iron (16%), phosphorus (7%), calcium (5%), and sodium (1%). Fourier transform infrared spectroscopy identified amorphous calcium phosphate. GGBs have not been previously described in the skin and have been rarely characterized with SEM/EDXA in other sites.