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Musculoskeletal pain phenotyping: Our end point should be clinical feasibility ‐ A commentary to Meisingset et al. “Novel approach towards musculoskeletal phenotypes”

The study's aim was to identify and validate phenotypes of patients with musculoskeletal (MSK) pain based on eleven common prognostic factors across the biopsychosocial domains. Using a sample of n=435 patients attending physiotherapy in primary care, latent class analysis identified five groups. The five groups mainly differed in terms of severity across the well-established prognostic factors. Outcomes at 3 months reflected baseline scores; those with a more severe profile had worse clinical outcomes. Two of the five groups were separated on differing patterns of mental distress and fear avoidance.