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EFFECTS OF SUCROSE LOAD ON THE BIOCHEMICAL COMPOSITION OF BLOOD, SALIVA AND URINE FROM CYSTIC FIBROSIS HOMOZYGOTES AND HETEROZYGOTES AND HEALTHY CONTROLS

Ceder, O., Bardoń, A., Hellsing, K. and Kollberg, H. (Department of Pediatrics, University Hospital, Umeå, Sweden, Department of Clinical Chemistry, University Hospital, Uppsala, Sweden, Department of Biochemistry, Institute of Sport, Warsaw, Poland and Department of Pediatrics, University of Kuwait, Safat, Kuwait). Effects of sucrose load on the biochemical composition of blood, saliva and urine from cystic fibrosis homozygotes and heterozygotes, and healthy controls. Acta Paediatr Scand, 1983; Suppl. 309:33. A disturbance in the metabolism of carbohydrates has been suggested to be responsible for many of the clinical symptoms in cystic fibrosis. To study this, the biochemical compositions of blood, mixed saliva and urine from homozygotes and heterozygotes for cystic fibrosis and healthy children and adults were compared before and after an oral load of sucrose. In blood, the fasting values of glucose, pyruvate and lactate were similar in the four groups. In saliva, the fasting concentrations of protein, sodium, chloride and potassium were significantly increased for homozygotes. Heterozygote saliva values were intermediate, although not significantly different from those of controls. The urinary concentrations of sodium, chloride, potassium and calcium were also significantly increased in the homozygotes. Again, heterozygotes values were intermediate and did not differ significantly from control values. Sucrose intake caused greater increases in the blood levels of glucose, lactate and pyruvate in the homozygotes and heterozygotes than in their respective control groups. Reversal of the increased concentrations occurred most quickly in the homozygotes and 150 min after sucrose intake the glucose and lactate concentrations were significantly lower in this group than in control children. In saliva significantly lower concentrations of sodium, chloride and potassium were found in the homozygotes and heterozygotes 30 and 90 min after sucrose intake than in the fasting state. Thus, their salivary concentrations of electrolytes became closer to those of controls. In controls sucrose intake caused an increase in the activity of ribonuclease in the saliva while the electrolyte values were unaffected. Limited effects of the sucrose intake were seen on the urinary values in the four groups.