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Associations between an abbreviated CAIDE score and amyloid chronicity

Efforts to quantify dementia risk have led to the development of indices that include health factors, like the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) index. Prior studies demonstrate that higher CAIDE is associated with cognitive decline and neurodegeneration. Few studies have analyzed the association between CAIDE and Alzheimer’s disease (AD)‐related pathophysiology, like beta‐amyloid. Recent studies suggest that duration of beta‐amyloid positivity (amyloid chronicity) is associated with cognitive decline. It is unclear whether health factors contribute to the onset of beta‐amyloid accumulation. This study examines the relationship between the three cardiovascular components of the CAIDE score and amyloid chronicity as assessed by [C‐11]PiB PET imaging.