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Neurotoxicity of anesthetics.

Anesthetic toxicity can be strictly defined as a potentially harmful action or effect that is not part of the expected anesthetic or pharmacologic action of the agent. Such a definition would exclude the undesirable effects of an overdose of an anesthetic agent (wherein the expected pharmacologic effects are simply exaggerated) or a recognized expected pharmacologic effect that might in certain conditions be hazardous (for example, increased cerebral blood flow and intracranial pressure in patients with brain tumors). In this chapter I shall not adhere to the strict definition of toxicity but will instead also consider exaggerated or undesirable expected pharmacologic effects.