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1583 PROGNOSTIC VALUE OF PROMINENT SUBARACHNOID SPACES IN MACROCEPHALY

Diameters of the extracerebral frontal space (hereinafter referred to as the frontal subarachnoid space) were measured on the CAT scans of 80 children, their ages ranging from 0-24 months. The maximal diameters from the outer surface of the cortex to the inner table of the skull were measured and corrected, using the minification factor for the Siemens SIRETOM Scanner. Ten of these infants (8 males, 2 females) underwent CAT scans for evaluation of macrocephaly with head circumference above the 98th percentile. All had normal CAT scans except for a mean frontal subarachnoid space diameter of 2.24 mm. This differed significantly from 0.69 mm, the mean for 70 other children with miscellaneous neurologic disorders (p<0.05). Specifically, the frontal subarachnoid space diameter in children with macrocephaly and normal neurologic examinations differed significantly (p<-.05) from the measurement in 22 children with hydrocephalus (mean 0.77 mm), 7 children with idiopathic seizures (mean 0.45) and 6 children with spastic diplegia (mean 0.27). Six of these 10 infants upon follow up for a mean period of 13.6 months, continued to demonstrate normal development.Macrocephaly in infants, when associated with prominent frontal subarchnoid space may indicate an increased cerebrospinal pool and a relatively benign prognosis.