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Preprint Highlight: Cell division in tissues enables macrophage infiltration.

During embryogenesis, macrophages migrate through epithelial layers to reach their final destination, but the cellular mechanisms underlying this process, or how they relate to other models of epithelial infiltration, are not well understood. Combining live microscopy and genetics, this work describes a novel mechanism that allows macrophage infiltration. Epithelial cells round up and detach from the extracellular matrix during cell division, allowing macrophages to pass through. These results reveal a novel role for mitosis in development, and they also provide a model of how cell division can influence the recruitment of other cells to specific sites, with important implications for pathologies like inflammation and metastasis.