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Polymorphism of tandem repeat in promoter of 5‐lipoxygenase in ASA‐intolerant asthma: a positive association with airway hyperresponsiveness

Background:  5‐Lipooxygenase (ALOX5) and 5‐lipoxygenase‐activating protein (ALOX5AP) are known as key enzymes in cysteinyl‐leukotriene (cys‐LT) production, critical mediators in aspirin acetylsalicyclic acid (ASA)‐intolerant asthma (AIA). To date, studies of the promoter region of ALOX5 gene has revealed the potential influence of a variable number of tandem repeats of a Sp1‐ and Egr1‐binding motif, on the transcription rate.