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A nontumorigenic (mouse X human) cell hybrid inhibits tumorigenicity of its malignant mouse parent cell and unrelated human tumor cells in vivo.

This report describes the modulation of malignant through coinoculation in vivo of a malignant mouse (A9) cell line, and a phenotypically stable, nontumorigenic hybrid clone derived from it by fusion with a transformed mutant human cell. Thus, the tumorigenicity of the A9 cells was suppressed by the hybrid cells, but not by the unrelated normal cells. The hybrid cells also inhibited tumor development of unrelated human cancer cells.