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Allele and locus‐specific differences in cell surface expression and the association of HLA class I heavy chain with β2‐microglobulin: differential effects of inhibition of glycosylation on class I subunit association

The assembly of HLA class I antigens, and the contribution of the single N‐linked glycan to this process were examined. We observed a requirement for N‐linked glycosylation in the proper assembly and surface expression of HLA‐B locus products in particular, although considerable variation was seen within the allelic series of the HLA‐A and B loci. We conclude that the single N‐linked glycan can contribute in a major way to that conformation of the heavy (H) chain which is competent to associate with the light chain β2‐microglobulin, and that the presence, rather than the type, of carbohydrate chain is important in this respect.