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New Lessons for Rotavirus Vaccines

Rotavirus infects nearly all humans early in their lives and can sometimes prove dangerous or fatal. In his Perspective, Glass recounts the successes of first and second generation vaccines against rotaviruses. Nevertheless he believes that two papers in this week's issue [Ball et al. (p. 101) and Burns et al. (p. 104)] illuminate aspects of the virulence of rotavirus and its susceptibility to immune attack that may guide the development of an even more effective third generation vaccine.