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The role of hydrogen sulfide in gastrointestinal tract functioning (review)

Abstract Despite a fairly large amount of literature data about the involvement of hydrogen sulfide in physiological and pathophysiological processes, its role in gastrointestinal tract functioning has not been studied sufficiently. This review systematizes and generalizes the mechanisms of H2S-associated regulation of gastrointestinal secretion and motility on the basis of literature sources processing and own research results. We analysed world professional literature and sources in Google Scholar, PubMed, MedLine, Embase, Cochrane, and data from more than 50 articles and books on the problem were processed in the article. This review gives a synopsis of the H2S function in the regulation of the secretory and motor-evacuation function, and in stimulating the reparative properties of the digestive tract, and indicates the main mechanisms.