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An outbreak of occupational allergic contact dermatitis caused by 2‐N‐octyl‐4‐isothiazolin‐3‐one among workers in an adhesive factory

A 54-year-old male was referred with bilateral hand dermatitis. This commenced 4 months after he started work as a production operator in an adhesive factory. He had previously worked with fabric dyes for 30 years without skin problems. On examination, he had low-grade bilateral hand dermatitis involving the tip of his thumb fingers, palm and dorsal hands, and extending to his arms. Examination of the material safety data sheets brought by the patient from his workplace showed exposure to a range of acrylates used as the adhesive base, irritants, including silicates, mineral oils, and ammonia, and 2-N-octyl-4-isothiazolin-3-one (octylisothiazolinone, CAS 26530-20-1) added as a biocide during adhesive manufacture. Patch testing performed according to International Contact Dermatitis Research Group guidelines demonstrated a + reaction to cobalt chloride and Myroxylon pereirae on day 4, and ++ reactions to octylisothiazolinone (0.1% pet.) on days 2 and 4. We subsequently identified 4 further workers from the same factory who were referred with hand dermatitis.