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Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.

The expression of several inducible enzymes for repair of alkylated DNA in Escherichia coli is controlled by the ada+ gene. This regulatory gene has been cloned into a multicopy plasmid and shown to code for a 37‐kd protein. Antibodies raised against homogeneous O6‐methylguanine‐DNA methyltransferase (the main repair activity for mutagenic damage in alkylated DNA) were found to cross‐react with this 37‐kd protein. Cell extracts from several independently derived ada mutants contain variable amounts of an altered 37‐kd protein after an inducing alkylation treatment. In addition, an 18‐kd protein identical with the previously isolated O6‐methyl‐guanine‐DNA methyltransferase has been identified as a product of the ada+ gene. The smaller polypeptide is derived from the 37‐kd protein by proteolytic processing.