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Deuteration mechanistic studies of hydrogenase mimics

Hydrogen production is one of the keys for a carbon free energy production. The use of hydrogenases is an excellent approach to fulfil this target since they produce hydrogen with extraordinary efficiencies. However, these enzymes have several short comes that may be resolved by using hydrogenase mimics. The design and synthesis of these mimics is a very active area of research, and the understanding of the mode of action of the mimics is particularly relevant to the future design of robust and productive catalysts. In this review we will discuss the role of isotopes (mainly deuterium) in disentangling key steps of the mechanisms of H2 activation by mimics of hydrogenases. Through selected examples we will focus on key aspects of the processes that, in many cases, have allowed to a better understanding of the mode of action of the natural enzymes, making a valuable contribution to the design of more efficient complexes for the production of hydrogen.