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Ketoconazole in the treatment of vaginal candidiasis.

In a preliminary open prospective study ketoconazole (Nizoral; Janssen) 200 mg twice daily for 5 consecutive days was found to be extremely effective in treating vulvovaginal candidiasis, producing cure rates of 96% at 7 days and 92% at 28 days. The oral route of administration has definite advantages over the vaginal route and improves patient compliance. No side-effects related to treatment were found in this study.