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Computer simulation of 3D electrical activity in the sinoatrial node

We have simulated 3D propagation of the action potential in the sinoatrial node to study the dynamics of the heart rhythm initiation. We have found that the leading center inside the sinoatrial node is formed by a group of cells, appears spontaneously under normal conditions, and migrates as acetylcholine is applied. The leading center drifts toward the center of the sinoatrial node, if we consider the effect of the surrounding atrial tissue. Abnormal electrical activity, rotating waves of action potential are observed in the sinoatrial node.