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Apoptosis inhibitor attenuates cardiac ischemia/reperfusion injury‐induced amyloid beta aggregation and dendritic spine loss in rats

Recently, several studies have reported the incidence of cognitive impairments in patients with acute myocardial infarction and heart failure. Mechanistically, dendritic spine loss in hippocampus, due to oxidative stress/inflammation induced apoptosis, is proposed as one of responsible mechanisms underlying cognitive impairments. However, the effects of z‐vad, which is an apoptosis inhibitor, on brain pathologies following cardiac ischemia/reperfusion (I/R) injury have never been investigated. We hypothesized that z‐vad alleviates brain damage in rats with cardiac I/R injury by reducing apoptosis, mitochondrial oxidative stress, and inflammation.