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Diagnostic value of HMGAs, p53 and β‐catenin in discriminating adenocarcinoma from adenoma or reactive atypia in ampulla and common bile duct biopsies

Biopsies from the ampulla of Vater and the common bile duct often pose diagnostic challenges. The aim of this study was to investigate the expression patterns of HMGA1, HMGA2, β‐catenin and p53 in biopsy specimens, in order to evaluate the potential diagnostic value of these proteins in differentiating adenocarcinoma from reactive atypia or adenoma.