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[A study on the allelic deletion of nm23 genes in human lung cancer.].

BACKGROUND
To explore the role of allelic deletions of nm23 genes in human lung cancer.


METHODS
Allelic deletions of nm23 genes were detected in 52 lung cancer tissue samples and their corresponding normal tissues as control by Southern blotting.


RESULTS
Loss of heterozygosity (LOH) of nm23-H1 gene was found in 14 out of 52 informative lung cancers , with a LOH rate of 26. 92 %; 2 of the 47 informative lung cancer tissues existed allelic deletion of nm23-H2 gene , with a allelic deletion rate of 4. 26 %. The LOH rate of nm23-H1 gene in cancer with lymph node or distant metastasis (42. 86 %) was significantly higher than that in lung cancer without metastasis (8. 33 %) ( P < 0. 01) . nm23-H1 LOH rate was also remarkably higher in undifferentiated and poor differentiated cancer (45. 45 %) than in moderate to well differentiated cancer (13. 33 %) ( P < 0. 05) . No relationship was found among the allelic deletion of the nm23-H1 and histoclassification of the tumor , P-TNM stages , size of the primary tumor , location of the cancer , and age of the patients ( P > 0. 05) .


CONCLUSIONS
nm23 gene may be involved in the differentiation and metastasis of human lung cancer , and nm23-H1 gene may play a more important role in the regulation of cell differentiation and metastasis of lung cancer than nm23-H2 gene.