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Mechanism of forelimb skin and skeletal muscle glucose uptake during Escherichia coli endotoxin shock in the dog.

This study was undertaken to investigate mechanisms of increased glucose uptake by forelimb skin and skeletal muscle during endotoxin shock. Anesthetized mongrel dogs were used. Forelimbs were perfused at either natural or constant blood flow. Temperature of the isolated forelimb was maintained at core temperature. Shock was induced by an IV injection of 2 mg/kg Escherichia coli endotoxin. Forelimb skin and skeletal muscle glucose uptake increased by 30 minutes of shock and remained elevated in the natural flow study. In the constant flow study, glucose uptake by both skin and skeletal muscle was increased at 30 minutes of shock but thereafter returned to control. The natural flow forelimbs were ischemic and hypoxic during shock, whereas the constant flow forelimbs were neither ischemic not hypoxic. Progressive hypoglycemia developed in both endotoxin shock groups. These data support the hypothesis that the mechanism of increases in forelimb skin and skeletal muscle glucose uptake during endotoxin shock is related to local tissue hypoxia.