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Microwave Assisted Synthesis of Some Novel Pyrimidine Derivative and Screening for their Biological Activity

A substituted pyrimidine derivatives were synthesized from chalcone
of 3-acetyl-2,5-dimethyl thiophene with corresponding active aldehyde
in microwave oven. The newly synthesized compounds were characterized
by TLC, IR, 1H NMR, 13C NMR spectral analysis. Pyrimidine
derivative were screened for their antibacterial activity in vitro by the
disk diffusion assay against two Gram-positive and two Gram-negative
bacteria and then the minimum inhibitory concentration (MIC) was
carried with the reference of standard drugs amoxicillin, ampicillin
and ciprofloxacin. The pyrimidine derivatives shows better inhibiting
action against both types of bacteria (Gram-positive and Gram-negative)
compared to amoxicillin, ampicillin and ciprofloxacin standard drugs.