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Overproduction of very low-density lipoproteins by livers of genetically obese rats.

SCHONFELD, G., AND B. PFLEGER. Overproduction of very low-density lipoproteins by livers of genetically obese rats. Am. J. Physiol. 220(5) : 11784181. 197 1 .-The hyperlipidemia of the mutant “fatty” strain of Rattus norvegicus has been characterized by the analysis of serum lipids and by lipoprotein electrophoresis (LPE). In comparison with their normal weight controls (NWC) and with normal Sprague-Dawley (S-D) rats the fatties had elevated serum triglyceride (TG), cholesterol, phospholipids, and free fatty acid levels. Pre-PLP was greatly increased and pand CULP decreased by LPE. The importance of overproduction in the maintenance of the hyperlipidemia was studied by perfusing the isolated livers of the above rats and measuring the TG output rates (in pmoles/g liver per hour). Livers taken from NWC and S-D had comparable tissue lipid levels and TG output rates were 0.30 and 0.38, respectively. Livers of fatties had increased tissue TG levels and increased TG output rates (0.76). More than 90y0 of the perfusate TG floated as very low-density lipoproteins (VLDL) in the ultracentrifuge. The data suggest that hepatic overproduction of VLDL is responsible, at least in part, for the hyperlipidemia.