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Expression of ERα and ERβ in lobular carcinoma in situ

Aims:  Oestrogen is a modulator of cell growth and differentiation in the breast. It mediates most of its function through members of the oestrogen receptor (ER) family, ERα and ERβ. Lobular carcinoma in situ (LCIS) is a known risk factor for the development of breast cancer; however, the use of tamoxifen for prevention is based upon data for ER+ (ERα) LCIS associated with invasion, but limited data exist on the use of tamoxifen in cases of ER+ (ERα) LCIS occurring in the absence of invasive carcinoma. The aim of this study was to examine ER expression in LCIS to determine the relationship of ERα to ERβ and, thereby, to determine whether it is of clinical value to measure ERβ along with ERα.