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Abstract 106: Targeting tumor associated pH regulators: Effective therapeutic strategy in ovarian cancer

The cancer cell survival relies on the over-expression of pH regulators that pump out excess protons/lactic acid, in turn acidifying the tumor microenvironment (TME) which further promotes immune suppression and metastasis. Targeting the pH regulatory molecules can neutralize the TME acidification and inhibit cancer growth. Vacuolar ATPase (V-ATPase) proton pump is the primary pH regulator. V-ATPase ‘V0a2’ subunit, a major pH sensing unit, is over-expressed on cancer cells in a wide array of tumor types including ovarian cancer (OVCA). Here, we examined the clinical relevance of V-ATPase ‘V0a2’ subunit in OVCA patient samples and its therapeutic potential in controlling tumor growth in pre-clinical mouse model. The gene data from Cancer Genome Atlas (TCGA) showed a high frequency of V-ATPase gene alterations in OVCA patients (74%, 448/606 patients). Specifically, the V0a2 gene was highly expressed in all stages of OVCA patients indicating its importance in a centralized physiological mechanism of pH regulation. Across the different OVCA grades, the V0a2 gene expression significantly increased with the tumor grade (Grade 1 Citation Format: Arpita Kulshrestha, Gajendra K. Katara, Safaa A. Ibrahim, Alexandria N. Young, Shayna Levine, Valerie E. Riehl, Mahmood Bilal, Alice Gilman-Sachs, Kenneth Beaman. Targeting tumor associated pH regulators: Effective therapeutic strategy in ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 106.