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Elevated myocardial repolarization lability and reduced arterial baroreflex sensitivity in subjects with high-normal blood pressure.

It is well accepted that cardiovascular risk and blood pressure are established in a continuous way [1]. This was emphasized in the recent guidelines on the diagnosis and treatment of hypertension (JNC VII and ESC–ESH, 2003) in which a sub-classification of normotension was introduced. Having a high–normal blood pressure increases the risk of developing a sustained hypertension [2] and may also confer an increased cardiovascular risk compared to optimal blood pressure [3]. However, this point remains a controversial issue [4,5].