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INCREASE OF COLONY FORMING CELLS IN PERIPHERAL BLOOD BY HISTAMINE INJECTION

For the purpose to study the humoral control of defensive responses, kinetics of colony forming cells (GFC) In peripheral blood of histamine ‐injected mice was assayed by modification of McCulloch and Till's method, with usual hematological examinations. Effects of histamine on adrenalectomized mice and hydrocortisone injection into intact animals were also examined in the same manner. In conventional mice, histamine caused marked leukopenia and a rise of hematocrit value by 15 minutes after the injection, the latter of which was restored within 30 minutes. On the other hand, high hematocrit value continued for more than 1 hour in adrenalectomized mice.