{'fraction_non_alphanumeric': 0.025, 'fraction_numerical': 0.0034482758620689655, 'mean_word_length': 5.4860335195530725, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Polydentate Aromatic Nanoparticles Complexed with Cu2+ for the Detection of Cysteamine Using a Smartphone as a Portable Diagnostic Tool

Despite the significant therapeutic use of cysteamine as drug in cystinosis, it also has some serious health issues such as idiopathic intracranial hypertension (IIH), Ehlers–Danlos syndrome, and eye related problems including blurred or loss of vision and pain due to eye movement, etc. Thus, it is important to measure accurate cysteamine levels in the body for clinical studies. However, most of the conventional methods used to detect cysteamine are time-consuming and expensive in nature. Therefore, in this regard, we have developed a chromogenic sensor which sequentially determines the Cu2+ metal ion and, consequently, exhibits potential ratiometric and selective colorimetric quantification of cysteamine in an aqueous/biological system. The morphology of the sensor was characterized by TEM, and it revealed some interesting features in that receptor 1 nanoparticles undergo self-assembly with the addition of Cu2+ metal ions which results in the filament formation (comet type) in aqueous medium and on subse...