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Multifunctional effects of anticomplementary agent K‐76 on carrageenan‐induced colitis in the rabbit

In this study the effect of K‐76. a sesquiterpcne compound with anticomplementary activity isolated from a fungus culture, on carrageenan‐induced colitis was studied from biochemical, histological and immunohistopathological aspects. K‐76 suppressed epithelial cell loss, crypt abscess formation, inflammatory cell infiltration, mucosal atrophy, and ulceration. Immunohistochcmical examination ofthe colonic mucosa showed that the number of IgG‐ and IgM‐positive plasma cells and the staining intensity for IgG and C3 were increased in carrageenan‐induced colitis, but these changes were inhibited by K‐76. Besides, serum mucoprotcin concentrations and CH50 levels were lower in the animals treated with carrageenan alone. K‐76 exerted multifunctional activity, although its mechanisms of action remain obscure.