{'fraction_non_alphanumeric': 0.026079136690647483, 'fraction_numerical': 0.0035971223021582736, 'mean_word_length': 5.396551724137931, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Langerhans cell histiocytosis presenting as a multi‐system disorder in an infant

Langerhans cell histiocytosis (LCH) is a rare disease that is poorly understood. Its clinical presentation may range from single or multifocal bone lesions to disseminated bone disease with multi-organ involvement that may affect the skin, liver, spleen, lung, central nervous system, bone marrow, gastrointestinal tract, and lymph nodes. Lesions affecting different organs have similar histopathological appearance and include a granulomatous collection of histiocytes admixed with variable numbers of lymphocytes, and eosinophil and neutrophil granulocytes. The incidence of LCH is around two to five cases per million population, and the disease has a male predominance. Its peak incidence is noted in children aged 1–4 years, but it can occur at any age. In this paper, we describe a case of multi-system LCH in a 60-day-old boy with an initial presentation of skin papules unresponsive to routine treatment. The history, radiological appearance, histopathology, and treatment options of the patient are discussed. Case report