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Asynchrony of ovulation and mating in mice treated with gonadotrophins.

The effect of pregnant mares serum gonadotropin (PMSG) on ovulation and mating in the postpuberal mouse during the immediate post-PMSG-injection period was investigated. Adult mice chosen without regard to the stage of the estrous cycle were injected with PMSG (5 iu). This treatment resulted in ovulation in 77.9% of the animals within 20 hours. These mice retained an average of 8.56 eggs in their oviducts. The incidence of spontaneous ovulation as estimated in the controls injected wtih saline was 5.5% with an average of 7.64 eggs in those animals which ovulated. Mating behavior in PMSG-injected animals was not different from the controls treated with saline. In order to determine whether follicle-stimulating hormone (FSH) or luteinizing hormone (LH) was the stimulator of ovulation animals were injected with either purified mammalian pituitary FSH or LH. Each hormone was effective in inducing ovulation. The administration of combinations of FSH and LH also resulted in ovulation within 20 hours with little evidence of any synergistic activity between these 2 hormones. When animals were injected with both PMSG and human chorionic gonadotropin (HCG) mating was greatly increased. It was concluded that the regimen of gonadotropin injections (PMSG-HCG) utilized to synchronize ovulation and mating in the postpuberal female mouse is in all probability inducing the ovulation of at least 2 different sets of oocytes: an initial set ovulated within 20 hours of the PMSG injection and a second set ovulated in response to the HCG administrered 48 hours after the PMSG injection. This results in mating in a high proportion of animals and essentially 100% ovulation.