{'fraction_non_alphanumeric': 0.03418803418803419, 'fraction_numerical': 0.008547008547008548, 'mean_word_length': 5.670886075949367, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Alteration of the microRNA expression profile and identification of miRNA/mRNA negative regulation pairs in neural tube defects.

MicroRNAs (miRNAs) are small, noncoding transcripts, and ∼ 22 nucleotides long, which belong to a class of endogenous small regulatory RNA molecules that target mRNAs and trigger either translational suppression or mRNA degradation [1–3]. Several stud-ies have shown that miRNAs play crucial roles in neurogenesis and development of nervous system [4,5] and have distinct expression patterns within the developing brain and central nervous system (CNS) [6]. Abnormal expression of miRNAs has also been reported in dysregulated neural tube (NT) development including NT defects (NTDs) [7,8]. To date,however,all NTD-related miRNA profiles were obtained from different microarray platforms, which always contain limited probes,and the data obtained are less precise in quantitative analysis. No quantitatively profiled global miRNA expression in mouse NTD fetuses has been characterized so far. To gain further insight of the