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An ageLOC Vitality formula improves endurance exercise in aged mice and energy metabolism in muscle mitochondria

There is much interest in nutritional products that can attenuate the effects of aging. We have screened several ingredients for their effects of opposing aging through a high‐throughput gene expression platform. On the basis of their gene expression patterns in skeletal muscle, heart muscle and brain tissues between young (5 months of age) and old (25 mo) mice, an ageLOC Vitality formula (AVF) was formulated containing Cordyceps sinensis Cs‐4 (a mycelia fermentation product of C. sinensis) and a standardized ginseng extract. In this study, we examined the effect of AVF (0.4 or 0.8 g/kg) fed to ICR mice (18 mo of age) for 47 days. As a measure of endurance, the exercise time to exhaustion increased on treadmill by +63% and swimming by +43% for AVF fed 0.4 and 0.8 g/kg respectively (p<0.01 vs. controls). The exercise‐induced increase in blood lactic acid was attenuated by AVF feeding (−24% and −22% vs. controls; p<0.01). AVF consumption increased catalytic activities of mitochondria Complexes I+III (+23% to +36%) and Complexes II+III (+15% to +35%) in old mice (p<0.05 vs. controls). In conclusion, the ageLOC Vitality formula enhances endurance exercise ability in aged mice by increasing the exercise time to exhaustion with improvement of mitochondria bio‐energy metabolism and attenuation of the exercise‐induced increase in blood lactic acid.