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Computational modelling of homo- and heterosynaptic LTD: insights from STDP, metaplasticity and spontaneous activity

Using the nearest-neighbour STDP rule with metaplasticity we show that to evoke homosynaptic LTD or depotentiation in the spiking model of granule cell is not easy. This is in accordance with number of experimental studies. On the other hand, heterosynaptic LTD which accompanies homosynaptic LTP is induced readily both in the model as well as in experiments. We offer possible explanation of this discrepancy based on STDP, metaplasticity and spontaneous activity. We suggest conditions under which it would be possible to induce homosynaptic LTD and depotentiation if our assumptions were correct.