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Preclinical and Clinical Results with an Ultrasonic Contrast Agent

Fritzsch Th, Schartl M, Siegert J. Preclinical and clinical results with an ultrasonic contrast agent. Invest Radiol 1988;23(Suppl 1):S302‐S305. In comparison to diagnostic radiology, ultrasound diagnostics has had no real contrast media. Theoretical considerations indicate that gas liquid systems seem to be favorable. The echocontrast agent SH U 454 is a system that releases minute gas bubbles that provide the contrast properties. Preclinical and clinical trials in more than 500 patients with right‐heart lesions proved the efficacy and tolerance of the agent. Initial investigations showed that SH U 454 also may be useful in fields (eg, urology, gynecology) other than cardiology.