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Epstein-Barr virus and infectious mononucleosis.

The overwhelming evidence that the Epstein–Barr virus (EBV) is the cause of infectious mononucleosis has recently been reviewed.1 Yet doubts are still being expressed regarding the causative role of the virus because a number of questions have remained unanswered. Among others, EBV had not been isolated from the oropharynx of patients and no EBV-specific IgM antibody responses had been demonstrated as a sign of primary infections. These deficiencies, owing to peculiarities of the virus and technical problems, have now, at least in part, been remedied. EBV is apparently restricted for its replication to cells of the lymphoid series, and even . . .