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Ultrastructural studies of the passage of gold thiomalate across the renal glomerular capillary wall.

In rats injected with gold thiomalate, electron-dense deposits were observed in the lysosomes of glomerular epithelial cells indicating passage through the capillary wall. The formation of these deposits appeared to be dependent on the sulfur-containing portion of the gold thiomalate molecule since similar, though not identical, deposits were seen in animals injected with sodium thiomalate. In 2 patients with gold nephrotoxicity, the kidney showed deposits in the peripheral capillary wall of the glomerulus resembling the deposits seen in immune-complex disease and differing in appearance from the “gold inclusions” produced by gold thiomalate.