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Clinical, Behavioral and Morphometric Changes Due to Cypermethrin Exposure in the Swiss Albino Mice Mus musculus L.

Cypermethrin-exposed clinical and behavioral signs accompanied by alterations in morphometric parameters in the Swiss albino mice Mus musculus L. were investigated. Twenty five adult male albino mice were divided equally into five groups where each mouse received: 0.10µL distilled water only (T0, served as control); 0.10mL (T1); 0.15mL (T2); 0.20mL (T3); and 0.25mL (T4) cypermethrin kg-1 body weight. Treatments were continued intraperitoneally each week for four consecutive weeks. During the experimental period, there were significant decreases in the initial and final body weights in the cypermethrin-treated mice but no abnormalities were observed in the control group. Mice exposed repeatedly to cypermethrin showed characteristic clinical and behavioral signs such as hind limb jerking, labored breathing, lesions, loss in body weight, necrosis, startle response, edema, eye discharge and hemorrhages. In addition, the insecticide was found to induce significant (P&lt;0.001) adverse effects on each of the morphometric parameters like gross body weight, feed intake, gain or loss in body weight and feed conversion ratio (FCR). From the present results, it is concluded that cypermethrin and other synthetic pyrethroids pose hazardous risks to mammals including human beings and therefore, judicious use of these insecticides should be ensured while applying them in agricultural as well as household purposes.