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Vascular Endothelial Growthfactor (VEGF) gene therapy using a on‐viral gene delivey system improves erectile function in a diabetic rat model

Introduction: Erectile dysfunction(ED) is a cause of decreased quality of life for over 70% of diabetic men. VEGF has been shown to improve overall endothelial and smooth muscle cell function in various models of ED. In this study we describe a novel technique for the in‐vivo transfection of VEGF in the rat corpus cavernosum using linear polyethylenimine (L‐PEI), a non viral gene delivery system.