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Correlation of Platelet-Lymphocyte Ratio towards the Incidence of Follicular Thyroid Carcinoma

Background: Recently, there is some consistent evidence that the inflammatory process is related to the development and progression of cancer. Platelet-lymphocyte ratio (PLR) may acts as simple biomarker for predicting the occurrence of cancer. Since fine needle aspiration could not distinguish between follicular thyroid carcinoma and benign lesion, the researchers were interested in conducting research correlation of PLR towards incidence of follicular thyroid carcinoma in Dr Soetomo Hospital Surabaya.
Methods: This study used secondary data from medical record of surgical pathology report diagnosed with follicular thyroid carcinoma who had undergone thyroid surgery at RSUD Dr. Soetomo Surabaya. Preoperative complete blood count was investigated then platelet-lymphocyte ratio was counted.
Results: The total research subjects were 40 people, consisting of 31 women (77.5%), 9 men (22.5%). Among three analyses between gender, age, and PLR towards follicular thyroid carcinoma, there is only one analysis which statistically had significant difference, that is correlation between PLR value towards incidence of follicular thyroid carcinoma (p value = 0.003). Two remaining analyses showed there were no statistically significant difference between gender (p value = 0.451) and age (p value = 0.336) towards follicular thyroid carcinoma. It was also found that patients with the higher PLR value had eight point five times higher suffering follicular thyroid carcinoma than those who had low PLR value.
Conclusion: According to this study, there was a statistically significant difference between PLR towards incidence of follicular thyroid carcinoma. The higher platelet-lymphocyte ratio (PLR) value, it is more likely to develop follicular thyroid carcinoma.

Keywords: Platelet lymphocyte ratio, platelet-lymphocyte ratio, follicular thyroid carcinoma