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N-benzyl-4-phenyl-1,2,3-triazole derivatives as in vitro inhibitors of the prostaglandin synthesis.

Numerous N-benzyl-4-phenyl-1,2,3-triazole derivatives were synthesized and tested. The compounds were prepared by nucleophilic substitution, 1,3-dipolar cycloaddition and usual functional group conversion reactions. Several derivatives were evaluated in vitro for their ability to inhibit prostaglandin synthesis and to displace labelled [14C] indomethacin from bovine vesicular gland microsomes. Some compounds showed biological activity.