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Murine erythroblasts do not contain histone H10.

Histone H10, which is related to the avian erythrocyte-specific histone H5, is known to accumulate in the chromatin of differentiating murine erythroleukemia cells. However, H10 was less than approximately 1% of the H1 in the spleens of anemic or pregnant mice even when as many as 65% of the cells in the spleens were nucleated erythroid cells. The H1 complement of erythroid spleens was nevertheless quite different from that of normal spleens. I conclude that H10 has no major role in normal erythroid development in mammals.