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Evaluation of matrix-assisted laser desorption ionization–time-of-flight mass spectrometry for typing of methicillin-resistant Staphylococcus aureus and a review of the literature

Matrix-assisted laser desorption ionization–time-of-flight mass spectrometry (MALDI-TOFMS) shows an excellent performance as a tool for microbial identification, which can analyze the strains not only for identification purposes, but also potentially for genetic typing. We present the typing results (compared with multilocus sequence typing) of 290 methicillin-resistant Staphylococcus aureus isolates by MALDI-TOFMS and a review of the literature about the application of MALDI-TOFMS on the molecular typing of other pathogens.