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DNA‐Synthetic Responses of Fractionated Human Lymphocytes Exposed to Lymphocyte‐Derived Mitogenic Factor

Human peripheral lymphocytes that have been exposed to (PHA) release mitogenic factors (MF) on subsequent incubation in fresh medium. In this investigation, MF‐rich supernatants were analyzed for their ability to induce DNA synthesis in various fractions of peripheral human lymphocytes. MF was found to induce higher DNA synthesis in T‐cell preparations than in unfractionated lymphoid preparations or B‐cell‐rich fractions. Evidence is presented showing that some types of non‐T cell can inhibit the MF response of T cells. These cells are nonadherent and nonphagocytic and require DNA synthesis to express their inhibitory activity. These results suggest that the regulation of the action of lymphocyte‐derived MF is cell‐mediated.