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Mast Cell Numbers In Rat Livers In An Acute Model Of Fat Embolism Are Reduced By Losartan But Not By Captopril

Fat embolism (FE) induced by IV injection of triolein (T) causes vasculitis, septal inflammation and fibrosis in rat lungs within 48 hrs (1). The damage is mitigated by two drugs acting on the renin‐angiotensin system (RAS): captopril and losartan (2). In the same organ, mast cell numbers are reduced in the lungs by losartan but not by captopril (3). This study examines whether captopril and losartan also modify the mast cell response in the liver.