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Reversibility of inhibition of chicken liver fructose diphosphatase by adenosine 5'-monophosphate.

Abstract The inhibition of chicken liver fructose diphosphatase by adenosine 5′-monophosphate (AMP) was found to be reversible. This is based on the observations that (a) incubation of the enzyme with AMP followed by extensive dialysis resulted in almost complete recovery of enzyme activity and (b) addition of Mg+ + during the reaction period would to a certain extent reverse the AMP inhibition.