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Multiple Sequence Alignment Using MATLAB

Sequence alignment is an important task in bioinformatics which involves typical database search where data is in the form of DNA, RNA or protein sequence. For alignment various methods have been devised starting from pairwise alignment to multiple sequence alignment (MSA). To perform multiple sequence alignment various methods exists like progressive, iterative and concepts of dynamic programming in which we use Needleman Wunsch and Smith Waterman algorithms. This paper discusses various sequence alignment methods including their advantages and disadvantages. The alignment results of DNA sequence of chimpanzee and gorilla are shown.