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Effect of Somatostatin Analogs on Gastric and Pancreatic Secretion 1

Summary GH-RIH and its two analogs, D-Trp 8 -somatostatin and D-Cys 14 -somatosta-tin have been tested for their effects on gastric and pancreatic secretion in chronic gastric and pancreatic fistula dogs. All three peptides caused similar competitive inhibition of pentagastrin-induced gastric acid and secretin-induced pancreatic bicarbonate secretions. This study indicates that GH-RIH analogs, which were shown to have a dissociated action on pituitary and endocrine pancreatic secretion, are essentially as equi-potent as GH-RIH itself on gastric and pancreatic secretions.