{'fraction_non_alphanumeric': 0.048223666193641546, 'fraction_numerical': 0.027858689969377848, 'mean_word_length': 5.040300751879699, 'pattern_counts': {'":': 0, '<': 46, '<?xml version=': 0, '>': 15, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
The Effectiveness of Educational Interventions on Breast Cancer Screening Uptake, Knowledge, and Beliefs among Women: A Systematic Review

There have been various systematic reviews on the significance of educational interventions as necessary components to encourage breast cancer screening (BCS) and reduce the burden of breast cancer (BC). However, only a few studies have attempted to examine these educational interventions comprehensively. This review paper aimed to systematically evaluate the effectiveness of various educational interventions in improving BCS uptake, knowledge, and beliefs among women in different parts of the world. Following the PRISMA guidelines, a comprehensive literature search on four electronic databases, specifically PubMed, Scopus, Web of Science, and ScienceDirect, was performed in May 2019. A total of 22 interventional studies were reviewed. Theory- and language-based multiple intervention strategies, which were mainly performed in community and healthcare settings, were the commonly shared characteristics of the educational interventions. Most of these studies on the effectiveness of interventions showed favorable outcomes in terms of the BCS uptake, knowledge, and beliefs among women. Educational interventions potentially increase BCS among women. The interpretation of the reported findings should be treated with caution due to the heterogeneity of the studies in terms of the characteristics of the participants, research designs, intervention strategies, and outcome measures.


Introduction
The burden of breast cancer (BC) is enormous. Approximately 2.1 million female BC cases were diagnosed in 2018 alone. Apart from being the most diagnosed cancer globally, BC is believed to be the leading reason of cancer mortality in over 100 countries [1]. The mortality rates of BC have increased in certain countries which have historically had a lower rate, such as sub-Saharan Africa [1]. This trend is probably due to the increase in the incidence rates of BC with limited access to early detection and treatment, and late-stage diagnosis [2,3].
Early detection of the disease can save lives and increase the chances of being treated efficaciously [4]. The diagnosis of BC during the local stage (stage I and some stage II) has an overall 5-year relative survival rate of 99% while the diagnosis of BC during the regional stage (stage II or III) has a 5-year relative survival rate of 85%. However, the late stage (some stage III and all stage IV) diagnosis of BC has an overall 5-year relative survival rate of 27% [5]. Numerous methods have been assessed as breast cancer screening (BCS) approaches, such as breast self-examination (BSE), clinical breast examination (CBE), and mammography (MMG) [6]. Getting regular screening examinations is the key strategy for detecting BC early and reducing the mortality rate of the disease [7]. However, a number of epidemiological studies on BCS behavioral uptake have been performed on community samples of various groups of women. Such studies have shown that the rate of BCS practice is low in various countries [8][9][10][11][12][13].
A good knowledge of BC and BCS is a prerequisite for the adherence to BCS among women [14]. A low level of knowledge among women in different parts of the world is linked to a low practice rate of BCS [8,[15][16][17][18][19]. Various international studies and guidelines have stressed the significance of educational interventions as necessary components of effective BCS programs in order to encourage BCS and reduce the burden of the disease among women [8,17,18,[20][21][22][23].
Demographic factors such as age, socio-economic status, and ethnicity are known to be associated with the use of health services and preventive health behaviors [24]. However, health education cannot modify demographic factors. Hence, developing efficient health education targeting modifiable individual characters is a challenge that in turn can predict preventive service usage and health behavior. Since beliefs are influenced by individual characteristics, they could provide an ideal target, as they affect behavior and are possibly modifiable. Beliefs distinguish individuals from the same background. However, at the same time, beliefs may reflect different socialization histories arising from demographic variation [25].
People's participation in health promotion programs is predicted using health behavior theories [26]. Through such theories, remarkable progress in studying the determinants of a person's health-related behavior in developing positive changes has been achieved [27]. Breast cancer screening is one behavior that is influenced by women's health beliefs [28]. This behavior has been explained in studies conducted in accordance with a variety of theories. In such studies, the meaning of BC and BCS were described by one concept related to one behavior, or through a more compound framework. By far, the most commonly Apart from BCS research, the effectiveness of health behavior theories has been proven to improve screening behaviors in other kinds of cancer. The Integrated Behavioral Model used by Serra et al. [29], for example, which involves constructs from the most commonly used theoretical models in health promotion (i.e., the Theory of Reasoned Action (TRA), the SCT, the HBM, and the TPB) was found to be successful to improve colorectal cancer screening. Another study by Huang et al. [30] suggested that variables pertinent to the TPB could successfully predict colorectal cancer screening uptake. Further, the HBM was effective to improve colorectal cancer screening uptake in general [31]. Cervical cancer screening, on the other hand, was predicted by using the TPB [32,33]. Additionally, Shida et al. [34] and Aldohaian et al. [35] found that the HBM and the TRA have a positive effect on cervical cancer screening outcomes. Apart from that, the HBM could positively affect prostate cancer-preventive behaviors by improving individual knowledge level and leaving positive effects on their health beliefs [36].
Previous reviews on the effectiveness of educational interventions revealed improved screening rates with culturally relevant components, multiple strategies, language-appropriate interventions, multilevel interventions, personal and cognitive interventions, and model-based educational interventions [37][38][39][40][41][42]. However, these studies only sampled participants from specific countries or regions, which do not offer an international view [39,40,42,43]. Moreover, previous reviews focused on MMG uptake [39], knowledge of BC and BCS, and model-based intervention studies [38], while beliefs have not been explored [21,41,43,44]. Furthermore, the instruments used to evaluate the outcomes affect the quality of findings. The use of standardized, valid, and reliable tools assures high-quality data and simplifies the interpretation of the findings. However, previous reviews found that little is known about the tools used to measure outcomes. A good understanding of these points can help in the development of an effective BCS program for women. Although the program content, methods of delivery, and the person who delivers the intervention play a critical role in improving the knowledge and behavior towards BCS among women, these features have only been reviewed in brief. In this systematic review, these features are reviewed in further detail.
Overall, this systematic review primarily aims to evaluate the effectiveness of educational interventions on BCS uptake, knowledge, and beliefs among women in different parts of the world. A comprehensive assessment of these interventions potentially offers evidence on their efficacy for the development of future projects to address BC. This systematic review also presents valuable recommendations on the content and methods of delivery of such programs based on current evidence. Such programs are expected to promote BCS uptake and subsequently reduce the morbidity and mortality rates of BC in the long run.

Materials and Methods
The review was registered and conducted according to the PRISMA guidelines (Supplementary Table S1) with the registration number: CRD42020148423.

Literature Search
For this review, a comprehensive literature search on four electronic databases, specifically PubMed, Scopus, Web of Science, and ScienceDirect, was conducted in May 2019. In order to identify relevant articles, a combination of keywords was used ( Figure 1). The inclusion and exclusion criteria were used to evaluate the gathered articles (Table 1). These criteria were executed in Figure 1. Two reviewers independently extracted data from the studies. Search strategy can be seen in the Supplementary Table S2. Non-intervention studies, irrelevant study designs (e.g., descriptive research), and studies that did not report quantitative valid outcome measures (e.g., studies that did not report values such as, frequency, percentage, mean (SD), P-value, or confidence interval).

Participants
Women aged eighteen years old and above, without history of BC.

Intervention
Health promotion and behavioral program on BCS targeted women.

Control group
Either usual care or no intervention, or minimal intervention or intervention other than the intervention groups.

Outcomes
Any of the following: BCS uptake (BSE (breast self-examination), CBE (clinical breast examination), MMG (mammography)), knowledge of BC and screening, health beliefs about BC and screening.
Publication year From January 2014 to May 2019.

Language
English.
Article type Original studies.  The Effective Public Health Practice Project (EPHPP) tool for intervention design studies was used to measure the quality of these studies. Using this tool, six domains, specifically research design, confounders, selection bias, blinding, data collection method, and dropouts and withdrawals, were evaluated. Each domain was valued as weak (one point), moderate (two points), or strong (three points). As for the total score, domain scores were averaged. As shown in Table 2, the quality of the studies was rated according to the following range of values: (1) weak quality: values of between 1.00 and 1.50; (2) moderate quality: values of between 1.51 and 2.50; (3) strong quality: values of between 2.51 and 3.00 [45,46]. Two reviewers independently evaluated the rating of these studies. Any arising disagreement on the rating was resolved with the involvement of a third reviewer.

Data Synthesis
The characteristics and results of the studies are summarized in both narrative and tabular forms can be found in the Table 2.

Results
The literature search on four electronic databases yielded a total of 957 articles. After reviewing the titles and abstracts, 422 articles were removed, resulting in a total of 50 full-text articles for further review. Following that, 28 articles were excluded after the application of the inclusion criteria. Hence, a total of 22 articles were retained ( Figure 1).

Conceptual Framework
As illustrated in Table 2, the conceptual framework was explained in 18 studies. Multiple models were used as a guide in the intervention development of five studies, where Fathollahi-Dehkordi and Farajzadegan [48], Lee-Lin et al. in 2015b [53], and Lee-Lin et al. in 2015a [57] employed the HBM and TTM, while Taymoori et al. [52] employed the HBM and The TPB and Tuzcu et al. [10] employed the HBM and the HPM.
The HBM was the most commonly used model (n = 10) [11,16,19,47,[49][50][51]56,60,62]. The HBM theoretical framework incorporates six constructs, namely: (1) perceived susceptibility, (2) perceived severity, (3) perceived benefits, (4) perceived barriers, (5) cues to action, and (6) self-efficacy. This model emphasizes that threats from health problems can affect health behavior. Women who perceive susceptibility to BC risk or believe that the disease is a serious problem are more likely to do the screening test. Besides this, women who experience more benefits and fewer barriers to the screening test, have high health motivation, and can successfully perform a behavior are also more likely to do the screening test [64,65]. Diverse demographic factors and knowledge may also influence their perceptions and indirectly impact their health-related behaviors, as suggested by the model [66].
Meanwhile, the TTM framework explains health behavioral change as a continuum of stages. One would advance from pre-contemplation (the stage of not thinking about the behavioral change) to the stage of contemplation (thinking about the change) before advancing to the action stage (implement the behavior) and finally, maintaining that behavioral change [67]. On the other hand, according to TPB, one's behavioral achievements are influenced by motivation (intention) and ability (behavioral control). This theory distinguishes three forms of beliefs, specifically behavioral belief, normative belief, and control belief [66]. Focusing on three points, specifically one's features and experiences, behavior-specific cognition and affect, and behavioral outcomes [68], the HPM views health as a positive dynamic condition, rather than the absence of disease. The increase in the level of one's well-being is directed by health promotion. The model explains the multidimensional nature of individuals, as they react within the environment to maintain health.
Apart from the above theories, Gondek et al. [58] and Goel and O'Conor [55] applied the SCT (n = 2) whereas Elder et al. [54] applied the EM (n = 1). The SCT explains that one's health behaviors are influenced by personal experiences, environmental factors, and actions of others. In order to achieve a particular behavioral change, the theory provides ways for social support to achieve behavioral change by instilling expectations and self-efficacy and utilizing observational education and any other reinforcements [69]. Meanwhile, as for EM, multiple levels of effect are considered to explore the behavioral change that guides the evolution of further comprehensive interventions [70].
Besides that, a total of 13 studies reported that the researcher(s) or main investigator(s) personally delivered the interventions [10,11,16,35,47,49,50,52,56,57,59,60,62]. Meanwhile, Gondek et al. [58] reported that a project director and/or health educator led the program delivery whereas Goel and O'Conor [55] reported that healthcare providers delivered the intervention. On the other hand, community healthcare workers provided the intervention in Elder et al. [54], while Mirmoammadi et al. [51] reported that a consultant delivered the intervention. In another study, Fathollahi-Dehkordi and Farajzadegan reported that a peer educator delivered the intervention [48]. However, four studies did not specify who delivered the intervention [9,19,61,63].
Other relevant strategies were also incorporated to handle the participants' needs, which included the involvement of peer support (n = 1) [52], BC survivors (n = 2) [52,58], spouses (n = 1) [60], and female physicians (n = 1) [58] in the intervention. Furthermore, a personally and culturally tailored delivery was employed in four studies [9,53,57,60] and individual consultation was employed in five studies [10,51,53,56,57]. -Both groups differed significantly in their performance and frequency of BSE at 12 months (p = 0.0001). -A significant improvement in knowledge (p = 0.003) and BSE (p = 0.001) for the intervention than the control group. -There were significant changes from baseline to six and twelve months in BSE benefits (p < 0.001), BSE barriers (p = 0.01), confidence (p < 0.001), and total HBM scores (p = 0.04) in the intervention group compared to the control group.
Heydari and Noroozi, 2015 [49] Content: Breast anatomy/warning against BC/perceived susceptibility and severity/benefit and barriers of MMG/MMG performance. Method of delivery: Spoken/written materials. Delivered by the study researchers. Group education: Two training sessions lasting 45-60 min with a 1-week interval. In the form of group discussion/oral presentation/PPT slides/SMS reminder. Multimedia education group: Training through CD/educational SMS/SMS reminder.
-A total of 80% in the group training and 55% in the multimedia group performed MMG (p = 0.003). -Significant improvement in knowledge scores in the two groups at the post-test (p < 0.001). However, a comparison between the two groups found no difference (p = 0.128). -In multimedia group: barrier showed a significant decrease (p = 0.007), no significant changes in susceptibility, severity, MMG benefit and health motivation (p > 0.05). -In group education: significant improvement in health motivation (p = 0.01) and MMG benefits (p = 0.003), and significant decrease in barriers (p = 0.006). -Comparison of the two groups found no significant difference in the susceptibility, severity, and barriers (p > 0.05), but health motivation (p = 0.04) and benefit (p = 0.029) were higher for the group education than multimedia group. -MMG completion rate was higher in the group education than the control group, 33% vs. 13% (p = 0.02). -An improvement in knowledge in the group education than the control group (p = 0.04); however, in pre-post test knowledge change between the groups was not statistically significance (p = 0.08).

Kocaöz et al., 2017 [59]
Content: Breast anatomy/unusual changes in the breast/importance of BC/risk factors/early diagnosis/symptoms/treatment/BSE. Method of delivery: Spoken/written materials. Delivered by the study investigators, a session of 40 min in the form of visual presentation/participants' performance of BSE/an education brochure on BC and its screening/participation in screening programs.
-After education 28.4% of participants performed MMG, 69.9% practiced BSE, and 29.3% performed BSE regularly. -Significant improvement in health motivation (p = 0.03), barriers of BSE (p = 0.007), self-efficacy (p < 0.001), MMG benefit (p = 0.008), and MMG barriers (p = 0.001) were found, but no significant improvement in the scales of susceptibility, seriousness, and BSE benefits were observed (p > 0.05). Significant changes were detected between the two groups on knowledge (p < 0.001). -Significant changes were detected between the two groups on HBM constructs (p < 0.05). However, susceptibility (p = 0.18), severity (p = 0.9), and MMG barriers (p = 0.14) did not show significant differences. The TBHEP 1 h intervention included 2 parts, group teaching delivered by the study researcher followed by individual counseling by trained staff/the materials covered cultural, graphic like photos of both old and young Chinese women, Asian landscapes, and some dialogs between a Chinese grandmother, mother, and daughter/PPT/group discussions/Q&A sessions/face-to-face interactions. Control: A brochure emphasized caring for self. Reminder of follow-up survey with telephone calls in 3 months.
-Three months following the intervention: - The education group had higher susceptibility compared to the control group (p < 0.01). -12 months following the intervention: - The education group had higher knowledge than the control group (p < 0.05). - The education group had fewer barriers than the control group (p < 0.05).   -Six months post-intervention: - The rates of BSE (p < 0.001), CBE (p < 0.001), and MMG (p = 0.011) were higher among respondents of the intervention group than respondents of the control group. - The intervention group had higher susceptibility (p = 0.04), health motivation (p < 0.001), BSE benefit (p < 0.001), self-efficacy (p < 0.001), and lower barrier of BSE and MMG (p < 0.001) than the control group. -No difference in seriousness (p = 0.400) and MMG benefits (p = 0.137) subscales between the two groups.
Meanwhile, seven studies that explored the practice of BSE among women reported consistent results. There were five experimental studies that involved two groups [9,10,16,19,50] and revealed higher BSE among the participants in the intervention group, as compared to the participants in the control group (p < 0.05), after the intervention. Likewise, two pre-post studies found a significant improvement in the rate of BSE performance among the participants after the intervention [59,62]. However, six studies on the CBE uptake reported conflicting results. Freund et al. [9] and Masoudiyekta et al. [19] did not find any significant difference between the two groups after the interventions (p > 0.05), while four other studies showed that the intervention groups recorded significant levels of CBE performance, as compared to the control groups (p < 0.05) [10,48,51,54].
Additionally, a total of 13 studies assessed the changes in MMG uptake among the participants after they received education but reported contradictory results. Five studies revealed that the MMG uptake improved significantly among women in the intervention group after they received education, as compared to those in the control group (p < 0.05) [10,19,51,54,55]. In another study, Taymoori et al. [52] found that, after adjusting for marital status and healthcare centers, the participants of HBM (AOR = 5.11, CI = 2.26-11.52, p < 0.001) and TPB (AOR = 6.58, CI = 2.80-15.47, p < 0.001) groups were five and six times more likely, respectively, to obtain MMG relative to the participants of control groups. Likewise, Lee-Lin et al. in 2015a [57] revealed that, after controlling for age, marital status, and age when participants moved to the United States, women in the intervention group were nine times more likely to complete MMG than women in the control group (AOR = 9.10, CI = 3.50-23.62, p < 0.001). Wu and Lin [56] further implemented a sub-group analysis of age, length of residence in the United States, and insurance status to evaluate the intervention's effect on MMG uptake. A significant difference between groups was observed in participants with insurance coverage for MMG (56% in the intervention group versus 34% in the control group) (p = 0.03) and elderly women (65 years or older) (51% in the intervention group versus 25% in the control group).
When it comes to comparing different educational interventions, Heydari and Noroozi [49] showed that, after the intervention, 80% of the participants in group training and 33% of the participants in the multimedia group practiced MMG (p = 0.003). Meanwhile, Seven et al. [60] did not find any statistically significant difference in the screening rate among the three methods of education (p = 0.067). However, women who were involved in a group had a higher rate of MMG screening than women who were educated individually (p = 0.034). HBM assessed through 6 items on susceptibility, 5 items on seriousness, 5 items on benefits, 5 items on barriers, 5 items on self-efficacy, 6 items on cues to action. Scores were rated on a 5-point Likert scale that ranged from totally agree (5) to totally disagree (0). Scoring for the cues to action construct was rated in percentages.
Accepted items had content validity ratio larger than 0.62 and content validity indices larger 0.79. Cranach's alpha = 0.76.  BSE was tested using 6 items, with 2 options (1 score for I do and 0 score for I do not know/do not answer) -20 items on knowledge (1 score for correct answer and 0 score for wrong answer) -HBM was assessed using questions on susceptibility (8 items), severity (8 items), benefits (6 items), barriers (6 items), self-efficacy (8 items). All scales were rated based on a 5-point Likert scale that ranged from totally agree (5) to totally disagree (1).
-The validity of the questionnaire items was evaluated with CVI of higher than 0.15, and CVR of higher than 0.77. The reliability values for knowledge, susceptibility, severity, benefits, barriers, and self-efficacy were 0.85, 0.75, 0.80, 0.79, 0.82, and 0.77, respectively.  12 items (wrong-right checklist) were used to assess knowledge. Right response was given 1 score and wrong response was given 0 score. -Beliefs were evaluated by 5 subscales of CHBMS construct including, sensitivity (3 items), severity (7 items), barriers (10 items), benefits (6 items), and health motivation (7 items), with a Likert scale that ranged from strongly disagree "1" to strongly agree "5".
Cronbach's alpha for sensitivity = 0.82, severity = 0.84, barriers = 0.73, benefits = 0.72, and health motivation = 0.77. The questionnaire included items on socio-demographic factors and 37 items for both constructs (HBM + TPB) related to susceptibility (3 items), severity (7 items), MMG benefits (6 items), MMG barriers (9 items), self-efficacy (10 items), subjective norms (1 item), and perceived control (1 item). - The HBM was evaluated on a 4-point scale ranging from strongly disagree "1" to strongly agree "4". Self-efficacy scale ranging from not at all confident "1" to very confident "4". - The TPB construct, subjective norms, and behavioral control were each assessed through 1 item. With scoring using a 4-point scale that ranged from never "1" to often "4". -MMG screening was ascertained through self-report + medical records. Psychometric properties were not reported. As for the ultra-Orthodox Jewish group, Freund et al. [9] found a significantly greater number of women from the intervention group performed MMG screening (p = 0.009) after the intervention, as compared to the non-intervention group. On the other hand, when it came to the Arab population group, there was no significant difference between the intervention and control groups (p > 0.05). Apart from that, Gondek et al. [58] and Kocaöz et al. [59] employed a pre-post study design and reported that 33.0% and 28.4% of women in the respective post-intervention assessment completed MMG. The scores of BC behaviors were found to significantly improve among women in the intervention group, as compared to women in the control group, after the intervention (p < 0.05) [47].

Knowledge of Breast Cancer and Breast Cancer Screening
A total of 16 studies reported contradictory results on the changes in BC and BCS knowledge levels among the participants (before and after intervention). Different tools were used to evaluate the knowledge levels, where higher scores indicate greater knowledge. There were five studies that used valid and reliable knowledge tests [16,47,50,61,63]. Three studies reported that the participants in the intervention group recorded significantly higher knowledge scores than those in the control group [16,47,50]. Likewise, Vasishta et al. [63] and Rabbani et al. [61] employed pre-post study designs and observed a significant increase in BC knowledge (between the pre-and post-intervention).
Meanwhile, six studies reported on either the validity or reliability of the knowledge tests [19,49,51,53,60,62]. Although the knowledge scores of both intervention and control groups in the post-test in a study by Heydari and Noroozi [49] showed a significant increase (p < 0.001), no significant difference in the knowledge scores between both groups was reported (p = 0.128). Likewise, Seven et al. [60] reported a statistically significant improvement in the knowledge mean scores after intervention for each group of the three methods of education (p < 0.001) but no significant difference in the knowledge mean scores among the three groups (p > 0.05). Three studies showed that, after the intervention, the knowledge scores of the intervention group were significantly higher than that of the control group [19,51,53]. In addition, the participants' knowledge scores in a study by Ouyang and Hu [62] increased significantly after the intervention (p < 0.013).
Besides that, five more studies assessed changes in the knowledge level but the psychometric properties of the instruments used in these studies were not reported [11,48,54,55,58]. Fathollahi-Dehkordi and Farajzadegan [48] showed a significant mean difference in the knowledge scores between the control and intervention groups following the intervention (p < 0.001). However, Goel and O'Conor [55] and Elder et al. [54] reported no significant differences in the knowledge scores of both groups after education (p > 0.05). Nevertheless, Goel and O'Conor [55] reported a significantly higher knowledge score among the participants in the intervention group (p = 0.04). Gondek et al. [58] and Yılmaz et al. [11] employed the pre-post study design and detected a significant improvement in the knowledge mean scores from the pre-test assessment to the post-test assessment (p < 0.05).
For instance, Lee-Lin et al. in 2015b [53] found that women in the education group recorded higher perceived susceptibility (p < 0.01) and lower perceived barriers to BC (p < 0.05) in the post-intervention than the control group. In another study, Heydari and Noroozi [49] found a significant decrease in the perceived barriers for both groups following the intervention (p < 0.05). As for the education group, health motivation (p = 0.01) and perceived benefits of MMG (p = 0.003) were found higher in the post-test but no statistically significant differences were reported in the multimedia group regarding perceived susceptibility, perceived severity, perceived benefits of MMG, and health motivation (p > 0.05). Conversely, the comparison of both education and multimedia groups showed no changes in the perceived barriers, perceived susceptibility, and perceived severity subscales (p > 0.05) but health motivation (p = 0.04) and perceived benefits (p = 0.029) were found higher in the education group as compared to the multimedia group.
Adding to that, Fathollahi-Dehkordi and Farajzadegan [48] found that all constructs of health beliefs were significantly impacted by time and time-group interaction (p < 0.001). The effect of the group factor was found to be significantly associated with perceived sensitivity, perceived benefits, and health motivation subscales (p < 0.05). Meanwhile, Seven et al. [60] reported no significant differences among the three educational groups in the scores of all subscales of health beliefs before and after education (p > 0.05), except for the scores of the health motivation subscale. Eskandari-Torbaghan et al. [47] found that, after the intervention, perceived susceptibility, perceived benefits, and perceived barriers improved significantly among women in the intervention group, as compared to women in the control group (p < 0.05). However, no statistically significant differences between both groups for the subscales of perceived seriousness and self-efficacy (p > 0.05) were reported.
Two studies revealed an increase in the mean scores for all HBM constructs for the experimental group, as compared to the control group, after the intervention (p < 0.05) [19,50]. Ouyang and Hu [62] employed a pre-post study design and found significant improvement in the perceived benefits, confidence, and perceived seriousness among the participants after the intervention (p < 0.05). However, no statistically significant differences for perceived susceptibility and perceived barriers (p > 0.05) were observed. The participants demonstrated substantial changes in all HBM and TPB constructs (p < 0.05) [52].
On the other hand, Akhtari-Zavare et al. [16] reported that the intervention group recorded significant changes in the scores of perceived benefits of BSE (p < 0.001), perceived barriers of BSE (p < 0.01), the confidence of doing BSE (p < 0.001), and total health beliefs (p = 0.04) after education compared to the control group. However, the study found no significant differences between the intervention and control groups for the remaining components (p > 0.05). On the other hand, Kocaöz et al. [59] reported significant improvements in health motivation (p = 0.03), perceived barriers of BSE (p = 0.007), confidence of doing BSE (p < 0.0001), perceived benefits of MMG (p = 0.008), and perceived barriers of MMG (p = 0.001) after the intervention. No significant improvement in perceived susceptibility, perceived seriousness, and perceived benefits of BSE (p > 0.05) was found.
In another study, Mirmoammadi et al. [51] found that the post-intervention assessment detected significant changes in the HBM constructs (p < 0.05) between the intervention and control groups, except for perceived susceptibility and perceived severity (p > 0.05). Tuzcu et al. [10] also found higher perceived susceptibility (p = 0.04), health motivation (p < 0.001), perceived benefits of BSE (p < 0.001), and self-efficacy (p < 0.001) but lower perceived barriers of BSE and MMG (p < 0.001) in the intervention group compared to the control group after education. The study also reported no significant differences in perceived seriousness (p = 0.400) and perceived benefits of MMG (p = 0.137) after education.
Furthermore, adopting a pre-post study design, Yılmaz et al. [11] found that the mean scores of all HBM subscales improved significantly (p < 0.05). Using the 1990 Tampa survey items [54], the cancer screening group recorded significantly lower scores in perceived barriers, as compared to the physical activity group (p = 0.008).

Discussion
The continuous increase of BC among women has prompted researchers to propose different educational interventions to improve knowledge and beliefs about BC and BCS and subsequently, promote BCS uptake among women. The current systematic review focused on published intervention studies to assess the effects of these programs on BCS uptake, knowledge, and beliefs and to provide information on the characteristics of these interventions.
A standardized and validated instrument, namely the HBM scale developed by Champion [64] and Champion [65], was found to be commonly used by studies to assess health beliefs. However, different instruments were used by these studies to measure the knowledge, beliefs, and screening uptake of BC. Although self-reporting is an easier means to evaluate the BCS uptake, over-reporting may occur. Women may give socially desirable responses, rather than revealing their actual practice [42]. A medical report is believed to be a reliable method in terms of data accuracy to verify the BCS uptake accuracy. However, retrieving these records can be rather difficult.
Meanwhile, a linguistically convenient approach is commonly adopted as an effective intervention strategy to promote understanding among women. Multiple health models and theories (HBM, EM, HPM, SCT, TTM, and TPB), which were adopted in most of these studies, revealed health beliefs, knowledge of BC, and screening as mediators as well as the final target screening behavior. Hence, no positive behavior may take place without addressing and observing these mediators properly during the intervention design. In this systematic review, secondary outcome variables (knowledge and health beliefs about BC and BCS) were included since one or a combination of these variables can potentially affect the screening uptake change. Most of these studies found that HBM-based educational interventions successfully improved screening rates. Similar findings were reported in another review based in Turkey [40]. The current review is consistent with the previous review that explored the efficiency of theory-based interventions in elevating the BCS uptake [38].
Furthermore, most of the studies revealed favorable outcomes after the educational intervention, which were in line with another review by Agide et al. [21]. The reviewed studies used either single or multiple health behavior models or theories to improve BCS uptake, where the approach of multiple models appears to be more efficient in meeting the multidimensional needs of women [10,48,52,57]. These findings are consistent with the previous systematic reviews conducted by Naz et al. [38] and Secginli et al. [40]. Furthermore, the intervention content plays an essential role in achieving the target outcome. The current review provides detailed information on intervention content, which is consistent with previous work by Chan and So [42].
Suitable instrument selection to measure outcomes can assist in producing high-quality data. The adoption of the same instrument can help to facilitate comparisons of these studies. The variation in the instrument content may create difficulties in comparing these studies. Moreover, certain studies did not report the reliability and/or validity of their instruments, which makes the quality of their data questionable. Thus, the interpretation of the findings must be taken with caution.
Nonetheless, the strength of this systematic review is the inclusion of experimental studies that were conducted in high-and middle-income countries. However, several limitations of this systematic review are also identified. Firstly, only published articles from 2014 to 2019 were gathered for the review. Secondly, the variation in the study designs and methods utilized in the included studies made pooling of results impossible. Thirdly, the variation in the follow-up length in these studies also limited the ability to compare the efficiency of interventions across studies. Apart from the varying validity and reliability of instruments used, the use of different instruments to assess outcomes was also another limitation.

Conclusions
Despite the observed improvements in women's knowledge, beliefs, and screening practices following educational interventions, the current systematic review revealed a difficulty in proving the effectiveness of such programs given the inconsistencies in the reported findings. These discrepancies imply the need for more research. The implementation of a future comprehensive program that links the most effective intervention characteristics, mediators, and factors that influence BCS outcomes is suggested. Additionally, the discussed findings of this review present significant implications for researchers, healthcare workers, and intervention planners to produce BCS health educational interventions that target women. The knowledge obtained from this review can be used to design comprehensive BCS programs, which can help to strengthen the existing healthcare systems with the purpose of disseminating proper knowledge to wider communities.

Recommendations
As a result of the current systematic review, we present several significant recommendations on the development of educational interventions for higher BCS uptake. Firstly, it is recommended for future research to comprehensively examine educational interventions in order to provide strong evidence on their effectiveness. Additionally, to produce highquality data, more reliable resources to evaluate screening practices are recommended, such as medical reports and the use of standardized validated instruments, such as the CHBM scales to assess health beliefs, rather than relying on questionnaires.
Furthermore, we recommend the implementation of theoretically based interventions to promote women's BCS behaviors. Theoretical and model-based programs are more successful than programs that are not based on theories or models since these programs are based on an accurate understanding of the health behavior mechanism changes which result in successful plans. Moreover, we suggest that the multiple model based educational intervention approach is to be utilized as guidance for interventions to understand the cultural and psychosocial factors that influence BCS behaviors. Educational interventions that employ a multiple models method have been found to be more effective in meeting women's' multidimensional needs [52]. Such models account for social, cultural, and economic barriers which may promote women's health beliefs.
Besides that, the intervention content should include key messages on knowledge and beliefs related to BC and BCS, and information on the importance and effectiveness of screening tests. Moreover, the intervention programs with the use of live demonstration (such as videos and printed materials) can be implemented individually or with in-group sessions by healthcare providers or lay instructors. Powerful and well-designed RCTs that provide a detailed description of the study and intervention are necessary.