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MECHANISM OF ANTI‐INFLAMMATORY ACTION OF GLUCOCORTICOIDS: RE‐EVALUATION OF VASCULAR CONSTRICTION HYPOTHESIS

1 The question whether constriction of local vessels is essential for the anti‐inflammatory action of glucocorticoids in carrageenin‐induced granulomatous inflammation was studied. 2 The vasodilator prostaglandin E1 injected into the granuloma pouch fluid increased the exudation of plasma protein into the granuloma tissue. 3 Noradrenaline significantly reduced plasma exudation, possibly through α‐adrenoceptor stimulation. 4 Cortisol and dexamethasone in doses sufficient to inhibit vascular permeability were without effect on the blood content in the granuloma tissue. 5 The results suggest that constriction of local vessels does not play an essential role in the anti‐exudative effect of glucocorticoids in chronic proliferative inflammation.