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[Dynamics of ECG changes during the treatment of depressive conditions with different variants of the course of endogenous affective psychosis].

The ECG parameters were studied and compared in normal subjects and patients suffering from affective psychosis running bi- and monopolar course during the development of the depressive phase and after its removal. At the prodromal stage before treatment, the patients manifested sinus tachycardia, changes in the ST configuration and QRS complex. On the histograms of RR intervals distribution, the modal value was shifted to the area of short intervals, the mode amplitude was higher whereas the variation range was more narrow than in the healthy subjects. Intergroup comparisons of the changes in the ECG parameters have shown that the disturbances were more remarkable in the patients with bipolar psychosis. At the initial stage of the treatment with antidepressants, the disorders were either unchanged or got intensified. The initial positive changes in the study parameters were seen only in the presence of the initial clinical improvement. However, the intergroup differences increased at the same time. The removal or appreciable reduction of the psychopathological symptomatology revealed a reversible nature of the changes in myocardial depolarization and disorders of conduction within the system of His bundle crura, seen before treatment. Still, the patients continued manifesting sinus tachycardia and changes in the cardiointerval histograms, particularly those with monopolar depressive psychosis.