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Diffuse alveolar damage and recurrent respiratory failure secondary to sertraline.

Sertraline is one of the most commonly used antidepression medications. In this case report, we present a 52-year-old male, smoker, who presented with respiratory failure, 6 months after starting Sertraline. We noticed an improvement in the clinical course after decreasing the dose of Sertraline and recurrent respiratory failure upon inadvertent rechallenge. Open-lung biopsy showed a picture of diffuse alveolar damage. Eventually, the patient improved after stopping Sertraline. This case demonstrates the relation of a drug causing lung disease, after excluding other causes, dechallenge, and rechallenge, in support of radiological and histopathological picture of drug-induced lung injury.