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Telomere Length and Aortic Valve Calcification

Objective: Short telomere length (TL) is associated with atherosclerosis development. Aortic valve stenosis, an age-related disease characterized by narrowing of the aortic opening, is mainly caused by aortic valve calcification. Development of aortic valve calcifications shares many similarities with atherogenesis. In this study, the relation between telomere length dynamics in valve tissue and the aortic valve calcification process will be determined.