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THE EFFECT OF EXTRACT FROM PLEROCERCOIDS OF GULL-TAPEWORM DIBOTHRIOCEPHALLUS DENDRITICUS ON WOUND HEALING IN MICE

In this work, the wound healing potential of the extract from plerocercoids of gulltapeworm D. dendriticus was first estimated in the mouse full-thickness wound model.
Both the evaluation of wound closure rate and the histological characteristics of the healing process were performed. In the course of the study, the effect of the extract on contraction and epithelization of wound was not revealed. At the same time, the results of histological analysis showed that the epidermis in the group of mice whose wounds were treated with the extract was less differentiated, and the newly formed connective tissue was less mature than in the group of control animals. In addition, differences were found in the composition of leukocyte infiltrate in the granulation tissue of experimental animals – there was a significant increase in the number of eosinophils and a tendency to a lower content of neutrophils. The results obtained indicate that treatment of wounds with extract from plerocercoids slows down the reparative processes, which, however, does not lead to significant changes in the rate of wound contraction. Perhaps, this difference is due to a change in the early stages of healing: extract stimulates eosinophils migration to the area of damage, while the number of neutrophils decreases. This can lead to a prolonged inflammatory phase and the associated slowdown in repair.