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Chronic vitamin A‐enriched diet feeding induces body weight gain and adiposity in lean and glucose‐intolerant obese rats of WNIN/GR‐Ob strain

What is the central question of this study? Previously, we reported that chronic feeding of a vitamin A‐enriched diet to euglycaemic obese rats (WNIN/Ob) ameliorated obesity. Does this diet exert similar effects even with a different genetic background, i.e. obese rats of the WNIN/GR‐Ob strain with impaired glucose tolerance? What is the main finding and its importance? Vitamin A‐enriched diet aggravated weight gain and adiposity/obesity in both lean and glucose‐intolerant obese rats of the WNIN/GR‐Ob strain. Therefore, the role of genetic factors and their regulation by nutrients in determining health and disease conditions assumes greater significance in experimental and clinical research.