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Genetics of atopy

The contribution of genetic factors to the development of atopy has been an intriguing issue. The work of Tshizaka [I] left little doubt about the central role of immunoglobulin E (IgE) specific to common, notably inhaled, antigens, in the production ofatopic disease. It has been suggested that an atopic individual is one who produces a positive skin-prick test response to any common Inhaled allergen. Whilst the pathophysiology of events that follow the binding ofantigen to mast cell-bound IgE is being clearly delineated, the mechanisms that underlie the individual's propensity to mount an IgE response to common antigens is not understood. Subjects and physicians have, however, recognized that familial clustering occurs, suggesting a genetic contribution.