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Preclinical Study of Nephroprotective Properties of Flarosukcin, New Urolitholytic Drug

The paper describes results of urolitholytic drug Flarosukcin effect on filtration-reabsorption renal function on modeled experimental renal insufficiency. Use of 2.0 ml/kg Flarosukcin increases diuresis in rats, reduces endogenous creatinine level in the blood and increases its excretion in urine reducing glomerular filtration and normalizing tubular reabsorption. Also the studied drug positively affects renal function of nitrogen excretion in rats, increases excretion of urea, endogenous creatinine, uric acid and consequently decreases their level in animals’ blood. Flarosukcin is shown to provide complex diuretic, spasmolytic and cytoprotective action on modeled experimental renal insufficiency and is believed to be promising for the further studying as a nephroprotective and urolitholytic drug.