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Fibrosis progression in patients treated for hepatitis C recurrence

is influenced by oxidative stress and FFA through independent mechanisms (3). Thus, it cannot also be excluded with certainty a direct effect of oxidative stress on circulating IMA levels. However, on a clinical point of view, we emphasize that, regardless the underlying molecular mechanisms, the main finding of our study resides on the association between IMA elevation and localized bacterial infections, which was supported by the experiments performed in cirrhotic rats exposed to acute endotoxin administration.