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Radial multigradient‐echo DCE‐MRI for 3D Ktrans mapping with individual arterial input function measurement in mouse tumor models

The purpose of this study was to provide proof of concept for a new three‐dimensional (3D) radial dynamic contrast enhanced MRI acquisition technique, called “Radial Entire Tumor with Individual Arterial input function dynamic contrast‐enhanced MRI” (RETIA dynamic contrast‐enhanced MRI), which allows for the simultaneous measurement of an arterial input function in the mouse heart at 2 s temporal resolution and coverage of the whole tumor. Alternating 2D and 3D projections contribute to the 2D heart image or 3D tumor data with a 3‐cm field of view. Sixty‐four 2D images of the heart are obtained during acquisition of each 3D tumor dataset. In a pilot study, global Ktrans and ve values were measured in four mice, in a respiratory motion‐animated subcutaneously implanted breast tumor model. This technique is expected to be most useful for the characterization of microvasculature in motion‐animated orthotopic tumors. Magn Reson Med 70:823–828, 2013. © 2012 Wiley Periodicals, Inc.