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Neurotoxic Effect of Intracranial Subarachnoid Application of Metrizamide and Meglumine Iocarmate

The present investigation was undertaken to compare the neurotoxic effects of subarachnoid application of the new water-soluble contrast medium metri­ zamide with those of meglumine iocarmate, which is considered to be the best and least injurious of the water-soluble contrast media now in use for myelo­ graphy. In preliminary tests on 4 dogs, in which 1.5 to 2 ml of metrizamide in a concentration of 170—300 mg I/ml was injected into cisterna magna, no definite effects on the ECG and the arterial blood and CSF pressure were found, neither were any neurologic signs observed. The contrast medium was run from the cisterna magna to the basal cisterns in all the dogs, and in one dog was subse­ quently brought into contact with the cerebral cortex for a brief interval, leaving small remnants to be absorbed in this region. The dogs were anaesthetized, intubated and kept on artificial respiration. Anaesthesia was induced with Nembutal (Mebumal Sodium) and continued with Fluothane (Halothane). Three of the four dogs were still alive 10 months later and in excellent condition. The fourth dog initially was free from neurologic