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Severe bilateral anterior cingulum injury in patients with mild traumatic brain injury

The cingulum, the neural tract connecting the orbitofrontal cortex with the medial temporal lobe, plays an important role in cognition (Bush et al., 2000). It is also important in memory because it provides cholinergic innervations to the cerebral cortex after obtaining innervation from the medial septal nucleus, the vertical nucleus of the diagonal band, and the nucleus basalis of Meynert via the medial cholinergic pathway (Nieuwenhuys et al., 2008; Naidich and Duvernoy, 2009; Hong and Jang, 2010a).