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The immunodepressive activity of Escherichia coli L-asparaginase in some transplantation systems.

Summary Escherichia coli l-asparaginase significantly prolonged the median survival time of skin grafts in H-2 - and H-Y -incompatible mice and promoted the outgrowth of L1210 leukemia allografts in the C57BL/6 strain, its effectiveness being in these systems comparable to or even higher than that of azathioprine. The immunodepressive effect was decreased neither by heat inactivation nor by simultaneous administration of l-asparagine.