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ADAM17‐enriched Exosomes Contribute to Neuronal Activation in Hypertension

ADAM17 is the prime mediator of Angiotensin Converting Enzyme 2 (ACE2) shedding, a process by which the ACE2 ectodomain is cleaved from the cell membrane and released in the surrounding milieu. ACE2 is a compensatory enzyme converting Angiotensin (Ang)‐II to Ang‐(1‐7). Recent studies have reported the presence of activated ADAM17 on exosomes, suggesting the possibility of shedding propagation from one cell to another. Here, we hypothesized that in hypertensive conditions, exosomes are enriched in ADAM17 and contribute to neuronal activation, possibly leading to enhanced sympathetic activity.