{'fraction_non_alphanumeric': 0.06423982869379015, 'fraction_numerical': 0.034261241970021415, 'mean_word_length': 4.4678362573099415, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Synthesis and Cytotoxic Activity of New Alkyl 2-Azido-2,3-Dideoxy-α-D-Lixo-Hexopyranosides From α,β-Unsaturated Sugar Enones and Sodium Azide

The synthesis of five new alkyl 2-azido-2,3-dideoxy-α-D-lixo-hexopyranoside (7a-e) obtained from α,βunsaturated sugar enones and sodium azide in the presence of acetic acid is described. One key intermediate, alkyl 2-azido-dideoxy-α-D-threo-hexopyranosid-4-ulose (6a-e), was used to obtain compounds 7a-e. The compounds 7a-e were obtained on good yields (65-78 %). The structures of the synthesized compounds were elucidated using infrared spectrometry and H and C NMR and elemental analysis. The antiproliferative activities were evaluated against four different human cell lines that are also described in this paper. The compound 7c exhibited good cytotoxicity activity against cancer cell lines HL-60, NCI H292, MCF-7 and HEP with values of 6.8 μg/mL, 9.9 μg/mL, 12.1 μg/mL and 5.1 μg/mL