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Role of gallbladder emptying and small bowel transit in regulation of bile acid pool size in man.

Abstract Eleven normal human subjects were studied after a 2 to 3 week equilibration period on a metabolic ward to determine the relationship of both gallbladder emptying rate and small bowel transit time to bile acid metabolism. ICG was used as a marker of gallbladder contents. Output of ICG in response to a standard test meal was monitored by a constant perfusion technique using 14 C-PEG as a nonabsorbable marker. Small bowel transit time was measured as the delay between ingestion of nonabsorbable carbohydrate and the appearance of H 2 gas on the breath. Pool sizes, synthesis rates, and fractional turnover rates of bile acid were measured by standard isotope dilution techniques after simultaneous administration of 14 C-cholic and 14 C-chenodeoxycholic acid. Gallbladder emptying was well approximated by first-order kinetics for 40 to 120 min following the test meal. The first-order rate constant of emptying (λ) ranged from 0.0127 to 0.0390 min. −1 Linear regression analysis revealed strong correlations between gallbladder emptying rate and pool sizes of both cholic (r = −0.76, p