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Release of salicylic acid from new multiphase bases with consideration of the preparation method

Abstract: The study evaluated the release of salicylic acid with new two multiphase ointment bases: Fitalite™ and Nourivan™ Antiox. Fitalite™ is a cream-gel base while Nourivan™ Antiox is a cream oil in water. Salicylic acid is a substance often used in the formulation of semi-solid dosage forms applied on the skin. The release rate of salicylic acid was examined depending on the base and the particle size of the active ingredient. For this purpose, formulations containing 5% salicylic acid were prepared and used for the study. Three different methods were used for the incorporation of salicylic acid into the bases: non-grinded, ground with the base for 15 minutes, and concentrate of salicylic acid with white soft paraffin (1:1). Measurements of the particles of the active substance in each of the preparations were also taken. Salicylic acid has been shown to be released to a greater extent from Fitalite ™ base. Qualitative analysis of the composition of the bases, in studies conducted by the Department staff, allows concluding that the amount and release rate of salicylic acid from the bases is influenced by its viscosity. This parameter has a significant impact on the level of trituration of salicylic acid. It was also found that the concentrate of salicylic acid with white soft paraffin (1:1) reduces the time of preparation of a suspension type ointment with salicylic acid, wherein the particle size accomplishes the requirements of pharmacopeia.