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Evidence for Distinctive Mechanisms of S-Nitrosoglutathione Metabolism by AdhC in Two Closely Related Species, Neisseria gonorrhoeae and Neisseria meningitidis

ABSTRACT The adhC gene from 11 strains of Neisseria gonorrhoeae was distinguished from its homologue in Neisseria meningitidis by the presence of a premature stop codon caused by a single base insertion. Mutational analysis showed that NADH S-nitrosoglutathione oxidoreductase activity was associated with adhC in Neisseria meningitidis but not in Neisseria gonorrhoeae.