{'fraction_non_alphanumeric': 0.027698185291308502, 'fraction_numerical': 0.0019102196752626551, 'mean_word_length': 5.736334405144695, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Scalp electroencephalographic spikes predict impending epilepsy in tuberous sclerosis complex infants: A longitudinal observational study

Dear Editors-in-Chief of Epilepsia: We read with great interest the article by Wu et al titled “Scalp EEG spikes predict impending epilepsy in TSC infants: A longitudinal observational study.”1 We applaud the authors for their pioneering work aimed at identifying features of the electroencephalogram (EEG) that predict the development of epilepsy and cognitive outcomes in infants with tuberous sclerosis. We consider this paper of great value. However, we are confused by the data reported in the abstract that are not supported by any data presented in the analysis results. In the abstract it is stated: “Generalized/ focal slowing, hypsarrhythmia and generalized attenuation were not predictive for the development of clinical seizures.” We were not able to find any supporting data in the article regarding the predictive value of generalized/focal slowing, hypsarrhythmia, and generalized attenuation for the development of clinical seizures. In the Results section, there are the following statements regarding generalized/focal slowing, hypsarrhythmia, and generalized attenuation: (1) “The interreader reliability/ kappa scores were calculated between the two central readers for five major findings on the EEG, namely IEDs, focal or generalized slowing, focal or generalized attenuation, hypsarrhythmia, and ictal events” and (2) “less than 5% of the EEG recordings were deemed to show any variation of hypsarrhythmia (modified vs classic hypsarrhythmia). Interictal epileptiform discharges (IEDs) seen as part of hypsarrhythmia were classified into the category of hypsarrhythmia.” If the authors have additional information supporting the conclusion that generalized/focal slowing, hypsarrhythmia, and generalized attenuation were not predictive for the development of clinical seizures, we kindly suggest this should be added to the article. Otherwise, we suggest they retract the statement in the abstract. Thank you for your consideration.