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45: Longitudinal Study of 7 Plasma Corticosteroids (CS) in Mother and Child at Birth and during the Neonatal Period

The adrenal cortex seems to play an important role in the newborn's adaptation to extrauterine life. Since systematic studies on multiple CS in the same human newborn have not yet been reported, progesterone (P), deoxycorticosterone (DOC), 17α-hydroxyprogesterone (17α), corticosterone (B), aldosterone (A), cortisone (E) and cortisol (F) were followed in a single 250 μl peripheral plasma sample in 12 vaginally delivered full-term infants of either sex. Mean concentrations (after automated LH-20 multi-column chromatography and specific radioimmunoassays) were in ng/ml:Besides marked materno-fetal CS differences, P, 17α and DOC (predominantly of placental origin) disappear rapidly with varying half lives. A, B, E and F, however, remain elevated in comparison with later infancy, reflecting high adrenal biosynthetic activity. *(Approved by parents and Hospital's Ethical Committee)