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Interferon-Alpha-Induced Depression: A Reply to the Letters to the Editor by Mahajan et al. and Porcelli et al.

financial security, impaired sexual satisfaction, small circle of friends, impaired physical role, body pain, low general health and vitality, reduced social functioning, impaired mental health, and impaired emotional role [6] . In conclusion, we advise that an early and comprehensive bioand psychosocial diagnosis and therapeutic treatment of patients with HCV infection during IFN-α treatment should be carried out as part of routine clinical care, so that their depressive symptomatology can be treated rapidly and their quality of life can be improved. In addition, it needs to be mentioned that, although IFN-α therapy is successfully used worldwide in the treatment of chronic HCV, knowledge about the complex biopsychosocial consequences of HCV infection and IFN-α treatment is still limited and requires ongoing research.