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Haemodynamic, Electrocardiographic and Cardiometabolic Changes after Overdose of Propoxyphene. An Experimental Study in Pentobarbitone-anaesthetized Pigs

severe propoxyphene overdose cardiac failure is responsible for approximately 75 % of the deaths (P. Sloth Madsen, J. Strom, S. Reiz & M. Bredgaard Sorensen, unpublished work). Studies in vitro on dog and cat heart muscles have demonstrated that propoxyphene and its primary metabolite norpropoxyphene reduce heart rate, reduce contractility and depress electrical conductivity (Holland & Steinberg, 1979; Amsterdam et al., 1981). This study concerns the haemodynamic, electrocardiographic (ECG) and cardiometabolic changes after intoxication with intravenous propoxyphene chloride in pentobarbitoneanaesthetized pigs and the treatment with prenalterol, dopamine and naloxone.