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Abnormal activity in reward brain circuits in human narcolepsy with cataplexy

Hypothalamic hypocretins (or orexins) regulate energy metabolism and arousal maintenance. Recent animal research suggests that hypocretins may also influence reward‐related behaviors. In humans, the loss of hypocretin‐containing neurons results in a major sleep‐wake disorder called narcolepsy‐cataplexy, which is associated with emotional disturbances. Here, we aim to test whether narcoleptic patients show an abnormal pattern of brain activity during reward processing.