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Influence of L-Glutamic Acid and L-Cysteine on Hemopoesis and Immune Status Indicators of Rats under the Toxic Effect of Organophosphorus Compounds

The rapidly increasing use of xenobiotics in our life stimulates to pay greater attention to the toxic effect of these compounds on human and animal organism. The purpose of our work was to study the changes in hematological and immunological parameters of rat blood under the action of chlorpyrifos (CPF) and additional administration of L-glutamic acid (L-Glu) and L-cysteine (L-Cys) both separately and in the complex. Material and methods. Studies were conducted on albino Wistar rats (males), weighing 200–220 g. They were housed in cages under standard laboratory conditions with a 12-h light/12-h dark cycle. All rats had free access to a standard rodent diet and water ad libitum. After 1 week of acclimatization, the rats were divided into five experimental groups. Animals from first (D1), second (D2), third (D3) and fourth (D4) experimental groups were intraperitoneally exposed to chlorpyrifos. After that rats from the second experimental group were treated with an aqueous solution of L-Glu rats of the third experimental group received L-Glu and L-Cys, rats of the fourth experimental group took L-Cys. Rats of the control group were administered to the appropriate amount of saline. Rats of the control group were administered to the appropriate amount of saline. After the end of exposure period, animals were euthanized. The total number of erythrocytes, leukocytes, white blood cell count, indicators of T- and B-cell immunity was determined in the blood. All procedures were conducted according to the European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes (Strasbourg, 1986) and General Ethical Principles of Experiments using Animals (First National Congress of Bioethics, Kyiv, 2001), in accordance with current legislation on animal experimentation in Ukraine. Results and discussion. Our results showed that the chlorpyrifos group of animals reflected in decrease in the total number of erythrocytes, the number of lymphocytes on the background of neutrophil increasing, changes in the number of total T-lymphocytes with medium receptor density. Conclusion. Additional administration of amino acids had a positive effect on animals