{'fraction_non_alphanumeric': 0.04201680672268908, 'fraction_numerical': 0.04137039431157078, 'mean_word_length': 4.712177121771218, 'pattern_counts': {'":': 0, '<': 3, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
[Flow cytometric analysis of deparaffinized nuclear DNA content in renal cell carcinoma].

The DNA content in renal cell carcinomas from 50 patients was determined retrospectively by means of flow cytometry (FCM), and related to histologic classification and prognosis of the same tumor. Paraffin-embedded materials were prepared for FCM. DNA histograms were evaluated by DNA index (DI). Aneuploid DNA histograms were found in 33 of 50 specimens (66%). The 5 year survival rate was 93 per cent for patients with diploid DNA histograms and 55 per cent for patients with aneuploid patterns (p<0.01). Aneuploid patterns were further classified into two groups. One was non tetraploid aneuploid DNA pattern and the other was tetraploid aneuploid DNA pattern. 5 year survival rate was 68 per cent for the former and 33 per cent for the latter (p<0.05). Aneuploid DNA patterns were demonstrated in 16 of 33 grade 1 tumors (52%), 15 of 16 grade 2 tumros (94%) and one grade 3 tumor (100%). The mean value of DI and 5 year survival rate were as follows: grade 1; 1.34, 86%, grade 2; 1.70, 36%, grade 3; 2.0, 0%. The difference between grade 1 and 2 tumors was statistically significant (p<0.01). But correlation between Robson's clinical staging and DNA content had no statistical significance. These results show that DNA content analyzed by FCM using paraffin-embedded materials had not only significant correlation to morphologic grading, but is one of most important indicator in the determination of prognosis for patients with renal cell carcinomas.