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THYROID HORMONE LEVELS IN OFFSPRING OF MOTHERS WHICH SMOKED DURING PREGNANCY AND HAD MALNUTRITION

On the model of the combined effects of passive smoking and reducing of energy intake diet of pregnant female rats was shown that their offspring of both sexes in the postnatal life have disrupted age ensuring body’s thyroid hormone. At the same time a significant number of offspring at an early age have expressed hyperthyroidism at the background of lower body weight. It was expected that this impact is the cause of a high percentage the death of pups of mothers during the first months of life, as had been shown by the authors earlier. It was found that the stress functioning of thyroid system in female offspring of experimental mothers has changing influence on hypothyroid status and leads to obesity at young age.