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[Diffusion of tetroxoprim and sulfadiazine in the cerebrospinal fluid of neurosurgery patients].

Two studies were conducted in neurosurgical patients to establish cerebrospinal fluid (CSF) and plasma levels of tetroxoprim (TXP) and sulphadiazine (SDZ) following the oral administration of co-tetroxazin in a standard dosage regimen. Both TXP (0,62-0,42 micrograms/ml) and SDZ (2,5-4,5 micrograms/ml) adequately penetrated into the CSF, resulting in concentrations above the MICs for most relevant pathogens. In relation to the respective plasma levels and under steady state conditions, CSF-availability is 37,5% for TXP and 31,8% for SDZ.