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Familial optic atrophy with diabetes mellitus.

: Familial optic atrophy with diabetes mellitus. J. D. Wilson, R. W. Simpson, M. L. Wahlqvist, I. Favilla and B. D. Tait, Aust. N.Z. J. Med., 1982, 12, pp. 48–51. 
 
 
 
A family of eleven members is described in which three siblings have optic atrophy, two of whom are insulin dependent diabetics, while the other has glucose intolerance. No evidence was found to suggest an autoimmune basis for this syndrome. There was no direct evidence that genetic susceptibility to this syndrome is HLA linked. The presence of DR2 and the absence of DR3 and DR4 in the affected individuals suggests that the diabetes mellitus in this syndrome is distinct from the common form of insulin-dependent diabetes mellitus.