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Technical considerations when obtaining and interpreting prostatic biopsies from men with suspicion of early prostate cancer: Part 2

Suspicious histology refers to ‘atypical small acinar proliferation’ (synonymous with ‘atypical glands suspicious for cancer’). Several series identified prostate cancer on subsequent re-biopsy in 40–50% of men with such suspicious findings on initial biopsy [15–17]. Chan et al. [16] felt that all men with suspicious lesions should be re-biopsied, regardless of tPSA, or why the areas were considered suspicious.