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Regulation of Tfr cell differentiation by KLF2 Mediated by KLF2 mediated Blipm1 and T-Bet expression

In normal circumstances, the germinal centre reaction (GC) in response to infectious agent results in production of antibodies (Ab) preventing aberrant inflammation and autoimmune diseases. In germinal centre the production of Ab is triggered by T follicular helper (Tfh) cells. In this fundamental process Tfr (T cell subset) play critical role in suppression of Tfh and B cell priming by maintaining the GC reaction. Many studies have reported that follicular regulatory T (Tfr) cell have derived by T regulatory cell (Treg) in response to viral infection. The follicular regulatory T cells shares many similar characters as Tfh and Treg cells