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Primary lymphoma of the breast

Experience with primary malignant lymphoma in the breast at the Barnes Hospital is reviewed and analyzed. Sixteen cases were found which satisfied our criteria. Eleven were classified as malignant lymphoma, histiocytic type, and five as lymphocytic type. No cases of Hodgkin's disease were identified. Several intesting associations were noted. Two cases were associated with pregnancy. One case was preceded by carcinoma and another by cystic mastitis; both cases were proved by biopsy. Bilateral breast involvement by tumor was seen four times. Primary mammary lymphoma is an aggressive disease, with a high predilection for the right breast. Histologically, the tumor tends to infiltrate between mammary ducts without destroying them. In spite of various therapies, only three patients survived 5 years.