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The uptake of [3H] pteroylglutamic acid into rat liver during regeneration and its incorporation into pteroylpolyglutamates of that organ.

The metabolism of injected [3H] PteGlu in hepatectomized rats was studied. Significantly higher radioactivity was found in all folate derivatives of regenerating liver. The results confirm the hypothesis according to which the decrease of endogenous polyglutamate content of regenerating liver might be ascribed to greater utilization rather than to lower synthesis of these coenzymes.