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LncRNA MNX-AS1 combined with YBX1 to promote bladder cancer proliferation, migration, and invasion through activiting Wnt signaling pathway


 Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes. Bladder cancer is one of the most common genitourinary malignancies, and its proliferation, migration and invasion also regulated by many functional lncRNAs. In our study, we found that lncRNA MNX1-AS1 was highly-expressed in bladder cancer tissues and cell lines. Moreover, higher MNX1-AS1 expression was correlated with poor survival of MNX1-AS1 patients. Mechanistically, we showed that MNX1-AS1 could interact with YBX1 and promotes its location at the promoter region of β-catenin, then to promote transcriptional activation of β-catenin. In addition, MNX1-AS1/YBX1 could promote bladder cancer cells proliferation, migration and invasion through active Wnt/β-catenin signaling by induce β-catenin transcriptional activation. Consistently, we find a new functional lncRNA MNX1-AS1 can regulate bladder cancer cells proliferation, migration and invasion by target β-catenin transcriptional activation together with YBX1.