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Glutamate dehydrogenase induction in the brain of streptozotocin diabetic rats.

Brain glutamate dehydrogenase (GDH) activity was compared between streptozotocin induced diabetic rats and insulin treated diabetic rats using crude and purified preparations from rat brain. V. of GDH increased significantly (p<0.05) while Km remained same in diabetic state when compared to control. Insulin treatment restored Vmax to normal values. The observed changes in the present study indicate disturbance in the metabolic pathway of glutamate which may bear importance in view of the physiological and cognitive disorders associated with diabetes.