{'fraction_non_alphanumeric': 0.025073746312684365, 'fraction_numerical': 0.004424778761061947, 'mean_word_length': 6.301075268817204, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Peripheral α‐helical CRF (9‐41) does not reverse stress‐induced mast cell dependent visceral hypersensitivity in maternally separated rats

Background  Acute stress‐induced hypersensitivity to colorectal distention was shown to depend on corticotropin releasing factor (CRF)‐induced mast cell degranulation. At present it remains unclear whether CRF also induces chronic poststress activation of these cells. Accordingly, the objective of this study was to compare pre‐ and poststress CRF‐receptor antagonist treatment protocols for their ability to, respectively, prevent and reverse mast cell dependent visceral hypersensitivity in a rat model of neonatal maternal separation.