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Valuable Characteristic of Patlak Parametric Imaging Based on Total-Body Dynamic PET Imaging: Higher Contrast For Tumor Lesions With Respect To Hypermetabolic Tissues


 Purpose To demonstrate the characteristics of high-contrast tumor lesions on total-body dynamic positron emission tomography (dPET) parametric images qualitatively and quantitatively. Method We reported the results of Patlak parametric images based on total-body dPET images of four patients with different types of tumor lesions. The contrast-to-noise ratios (CNRs) of the target tumor lesions were calculated with respect to hypermetabolic tissues, including the liver and ventricles, both on static PET and parametric images. Results Visual comparisons between the last frame of total-body dPET images and the generated parametric images illustrated the higher contrast of tumor lesions relative to other tissues in the patients. Visualization of the tumor lesions was reserved, while that of the livers and ventricles was diminished. The parametric images resulted in higher CNR values for the tumor lesions with respect to livers and ventricles compared to those given by dynamic PET images. The results were consistent in all the cases analyzed in this study. Conclusion Patlak parametric imaging provides the valuable characteristic of higher contrast for tumor lesions than hypermetabolic tissues, which helps in the clinical detection and diagnosis of tumor tissues.