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Transplantation Mediates Much of the Racial Disparity in Survival from Childhood-onset Kidney Failure.

Background: The role of kidney transplantation in differential survival in Black and White patients with childhood-onset kidney failure is unexplored. Methods: We analyzed 30-year cohort data of children beginning renal replacement therapy (RRT) before age 18 between January 1980 and December 2017 (n=28,337) in the U.S. Renal Data System. Cox regression identified transplant factors associated with survival by race. The survival mediational g-formula estimated the excess mortality among Black patients that could be eliminated if an intervention equalized their time with a transplant to that of White patients. Results: Black children comprised 24% of the cohort and their crude 30-year survival was 39% compared to 57% for White children (log rank p<0.001). Black children had 45% higher risk of death (adjusted hazard ratio (aHR) 1.45, 95% confidence interval (CI) 1.36, 1.54) and 31% lower incidence of first transplant (aHR 0.69, 95% CI 0.67, 0.72), and 39% lower incidence of second transplant (aHR 0.61, CI 0.57, 0.65). Children and young adults are likely to require multiple transplants, yet even after their first transplant, Black patients had 11% fewer total transplants (adjusted incidence rate ratio (aIRR) 0.89, 95% CI 0.86, 0.92). In Black patients grafts failed earlier after first and second transplants. Overall,Black patients spent 24% less of their RRT time with a transplant than did White patients (aIRR 0.76, 95% CI 0.74, 0.78). Transplantation compared with dialysis strongly protected against death (aHR 0.28, 95% CI 0.16, 0.48) by timevarying analysis. Mediation analyses estimated that equalizing transplant duration could prevent 35% (p<.001) of excess deaths in Black patients. Conclusions: Equalizing time with a functioning transplant for Black patients may equalize survival of childhood-onset ESRD with White patients.