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Detection of Autoantibodies Against Actin Filaments in Celiac Disease

Serum autoantibodies specifically directed toward intracellular cytoskeletal actin filaments (anti‐actin antibodies, AAA) were found to be associated with intestinal villous atrophy (IVA) in celiac disease (CD). The aim of this study was to assess IgA‐AAA with a commercial test that uses sections of rat intestinal epithelial cells in a well‐selected cohort of patients and to evaluate the relationship between the presence of serum IgA‐AAA and the severity of intestinal mucosa damage. J. Clin. Lab. Anal. 27:21–26, 2013. © 2012 Wiley Periodicals, Inc.