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Calcium as a versatile second messenger in the control of gene expression

The elevation of intracellular calcium is a major effector of stimulus‐induced physiological change in a variety of cell types. Such change is invariably complex and frequently involves the activation of gene expression. Calcium signals are often able to activate different subsets of genes within the same cell, the basis for which has been unclear. Recent studies have revealed that a number of differing properties of the calcium signal are responsible for distinct cellular responses. Microsc. Res. Tech. 46:348–355, 1999. © 1999 Wiley‐Liss, Inc.