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Analysis of HBV-DNA in Hepatitis B Patients with HBeAg Negative in JiLin Area

Objective: To illustrate the relationship between serum HBV-M and HBV-DNA in HBeAg-negative HBV patients. Methods: Serum isolated from HBV patients. FQ-PCR was used to detect the levels of HBV-DNA. ELISA was used to detect the serum HBV-M. Results: The positive rate of HBV-DNA was much higher in HBeAg-positive HBV patients (98.6%) than in HBeAg-negative HBV patients (48.7%). Among the different HBV-M patterns, the positive rate of HBV-DNA with positive HBsAg, HBeAb, and HBcAb was 59.4%; the positive rate of HBV-DNA with positive HBsAg and HBcAb was 32.3%; the positive rate of HBV-DNA with positive HBsAb, HBeAb, and HBcAb was 30.4%; the positive rate of HBV-DNA with positive HbeAb and HBcAb was 13.6%; the positive rate of HBV-DNA with positive HBcAb was 7.7%; the positive rate of HBV-DNA with positive HBsAb and HBcAb was 33.3%. Conclusion: HBV-DNA does still replicate in HBeAg negative HBV patients, and copies of HBV-DNA is a sensitive monitoring marker of monitoring HBV replication for those persons infected HBV.