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Increased Fibrinogen Consumption Following Endotoxin Injection in Cortisone-Treated Rabbits 1

Summary Rabbits prepared with prior injections of cortisone were given a single intravenous dose of E. coli endotoxin, Boivin type, at 100 μg/kg. The cortisone treatment potentiated intravascular clotting in these rabbits. Thus, excess disappearance of plasma 125I-fibrinogen radioactivity was demonstrated after endotoxin in each of 12 rabbits treated with 4 daily intramuscular injections of 25 mg of cortisone acetate, whereas only 1 of 13 saline-treated control rabbits showed similar changes. Consumption of plasma fibrinogen in the 6 hr after endotoxin was calculated from plasma fibrinogen levels and plasma fibrinogen radioactivity. Mean values were as follows: cortisone group, 79.4 mg% or 33.9 mg/kg; control group, 37.4 mg% or 13.2 mg/kg. The GSR was found in 3 cortisone-treated rabbits but in no control rabbit. Enhancement of endotoxin-induced clotting represents one important mechanism whereby cortisone could prepare rabbits for the GSR. The authors thank Miss Mary Jane Patch for preparation of the figures.