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ESTIMATION OF SERUM 25-OHD IN FULL-TERM AND PREMATURE INFANTS

Serum 25-OHD, serum calcium (Ca)and serum phosphorus (P) were measured in 40 full-term infants, 25 prematures and 39 mothers during 2 periods of the year. Mean values of serum 25-OHD in full-term and premature infants as well as in the mothers were found significantly higher during "summer" period (13.4 ng/ml in full-term, 14.5 ng/ml in prematures and 17.2 ng/ml in mothers) in comparison with the mean values during the "winter" period (full-term 7.6 ng/ml, prematures 5.7 ng/ml, and mothers 6.6 ng/ml). A weak linear correlation (p= 0.05) was found between serum levels of 25-OHD in newborns and their mothers. In 10% of the newborns the serum values of 25-OHD were 2 to 4 times higher than the respective values of their mothers Serum Ca in full-term and premature infants was independent of the values of serum 25-OHD and was related only to the duration of gestation. Serum P in full-term infants was significantly higher (6.7 mg/dl) during the "winter" period in comparison with the mean values (5.6 mg/dl) during "summer/ period. Normal levels of serum 25-OHD in full-term babies could prevent neonatal tetany by decreasing serum P which maintains the Ca/P ratio close to normal limits (Ca/P=1.6). Further studies are needed to confirm if the addition of 1a-25 (OH)2D3 to the milk could prevent neonatal hypocalcaemia in premature babies.