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First results on Compton camera system used for x-ray fluorescence computed tomography

Because of the ability to present molecular and functional information in organisms, nuclear medical imaging (NMI) is attracting more and more attention. Among NMI modalities, X-ray fluorescence computed tomography (XFCT) has the advantage that the tracers used in XFCT are not spontaneously decayed. The synthesis, storage of contrast agents is more convenient, the price of XFCT is much lower as well. However, XFCT usually has mechanical collimation to tell the incident photon direction, which results in the reduction of the detection efficiency. The Compton camera is an imaging modality, which does not need mechanical collimators in its structure, which makes Compton cameras have high detection efficiency. Therefore, it is a great idea to use Compton camera-based imaging systems to realize X-ray fluorescence (XF) imaging. In this work, the first XFCC imaging system in the laboratory environment is established, which consists of a 150keV X-ray tube and a single-layer Compton camera system based on the Timepix3 photon-counting detector (PCD). The element Gd (43keV) is used as the XF element. The first imaging reconstruction results of the XFCC system are represented.