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Steroid inhibition of leukocyte defense system in mycoplasmal uveitis.

Inoculation of the microorganismMycoplasma pulmonisinto the anterior chamber of the rabbit eye elicits a marked plasma cell-lymphocytic inflammatory response in the uveal tract. Because of the known inhibitory effect of corticosteroid drugs on the white blood cell immune response, the effect of exogenous local steroid on knownMycoplasmauveitis was evaluated. This model demonstrates the exquisite and adverse sensitivity of lymphocyte to steroids, the relative intensity of the antibody-producing plasma cells, and the inhibition of normal macrophage digestive function probably through steroid stabilization of the lysosomal membranes.