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Effect of noradrenaline reuptake blockade on evoked tritium overflow from mouse vasa deferentia and rat cortex slices previously incubated with 3H-noradrenaline.

1 Electrical stimulation of mouse vasa deferentia or of rat occipital cortex slices which had been previously incubated with 3H-(-)noradrenaline increased the overflow of tritium from the tissue above that occurring spontaneously. 2 Phentolamine (10 micrometers) increased evoked tritium overflow from vasa deferentia as did both phentolamine and yohimbine (1.25 micrometers) when applied to cortex slices. 3 Evoked tritium overflow from cortex slices was increased by cocaine (20 micrometers) but neither cocaine (11 micrometers) nor desmethylimipramine (0.5 micrometers) increased evoked tritium overflow significantly in the vas deferens. 4 In contrast to its effect when applied alone, in the presence of phentolamine, cocaine produced a further increase in evoked tritium overflow in both tissues. 5 Application of (-)-noradrenaline in the presence of cocaine produced a reduction in evoked tritium overflow which was quantitatively similar in both tissues. 6 It is suggested that the effect on tritium overflow of blockade of the reuptake of noradrenaline by cocaine is masked in mouse vas deferens by a compensatory process mediated through presynaptic alpha-adrenoreceptors. 7 It may be that such a compensation does not occur in cortex slices because of a difference in the architecture of the synapse in this tissue.