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Herpesviruses in tumors of postspawning Rana pipiens.

Herpesvirus particles were observed in renal tumors of Rana pipiens collected in rural Minnesota as long as 42 days after spawning. Tumor cytology differs from tumors of frogs collected during cold weather and suggests that the tumors are in transition from the virus particle-containing state to the inclusion-free state. The presence of viruses in tumors of frogs in breeding ponds may have epidemiological significance.