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Neurotensin Inhibits LH Release

Abstract The present studies were designed to assess the effect of neurotensin on the release of LH, FSH, and prolactin in long-term castrated female rats. The animals were implanted in the lateral ventricle of the brain with a cannula to allow the administration of either neurotensin or the vehicle. The peptide (30 μg, dissolved in saline) or the control saline solution was injected intraventricularly in a volume of 10 μl following pentobarbital anesthesia. Blood samples were collected at sacrifice 15, 30, and 60 min after injection. A significant decrease of serum LH levels was already present in neurotensin-treated animals at 15 min, and was maintained up to the end of the experiment. This decrease was not accompanied by any change in FSH or prolactin secretion. The results suggest that this tridecapeptide participates in the control of LH release and provide new data on the separate control of the release of the two gonadotropins.