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Effect of liposomes on hamster oral mucosa.

The histologic reaction to topically applied or intramucosally injected DPPC/chol (2:1 molar ratio) liposomes was investigated. No reaction to liposomes was observed 4 days after daily topical application. However, a mild focal immune type inflammatory reaction was observed after 21 days topical treatment. Intramucosal injection of liposome produced no irritation but a macrophage reaction limited to the injection site, which was followed by healing and complete tissue regeneration.