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The yin and yang of cancer therapeutics.

In this review, a potential theoretical framework for cancer therapeutics is presented, based on two concepts. The first concept considers cancer as a 'disease process' involving key regulatory pathways, and is discussed along with recent evidence and topics of special interest such as the combination of molecular diagnostics with developmental therapeutics. The second concept is the binary state concept of 'active/inactive' that seeks more relevant targets within the global molecular matrix of any given cancer. Here, these concepts are considered, along with the growing body of evidence that supports them. The 'binary' concept may facilitate both target selection and target validation.