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Relevance of the pharmacokinetics of non-steroidal anti-inflammatory drugs (NSAIDs) in children.

The pharmacokinetics of the NSAIDs is relevant to therapy in different ways: absorption, protein binding and distribution, metabolism and elimination. The pharmacokinetics of a drug is most relevant to therapy when plasma concentrations of the drug are related to efficacy and/or to side effects. The kinetic parameters then allow one to calculate the optimal dose regimen, i.e. the one maintaining plasma concentrations within the therapeutic range. The pharmacokinetic characteristics of the different NSAIDs relevant to therapy in children are reviewed.