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Immunoelectron microscopic localizaiton of antigens which react with islet cell cytoplasmic antibodies within human pancreatic beta cells

The presence of circulating autoantibody to islet cell cytoplasm is considered to be an important mrker of Type 1 (insulin‐dependent) diabetes mellitus. In the present study using islet cell cytoplasmic antibody positive patient sera as the first antibody, we studied the intracellulr distribution of its antigen at the electron microscopic level using the pre‐embedding immunoperoxidase method. Specific immunoreactivity was found in the membranes of beta cell‐secretory granules and cytoplasmic membranes. This result is compatible with the interpretation that the antigen(s) on the membranes of beta cell secretory granules is (are) the target of islet cell cytoplasmic antibody. © 1992 Wiley‐Liss, Inc.