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Primary Intraspinal Tumors in China: A Consecutive Surgical Series of 589 Patients


 Purpose: Primary intraspinal tumors are rare tumors of the central nervous system. There is a paucity of detailed clinical data on the tumors for neurosurgeons. The paper is to report the clinical characters of 589 patients with primary intraspinal tumors in China.Methods: Medical records of 589 patients with primary intraspinal tumor treated surgically with pathologic confirmation from January 2015 to December 2019 in our hospital were collected and reviewed. In each case, data about patient's age at surgery, sex, clinical presentation, anatomical location, vertebral levels and histological diagnosis were obtained and analyzed.Results: The entire cohort included 281 (47.7%) males and 308 (52.3%) females with a mean age of 48.1 years. Primary intraspinal tumors were most likely occurred on thoracic levels, counting 38.7%, compared with cervical 25.1% and lumbar 33.7%. 80.3% (472/589) of intraspinal tumors were intradural extramedullary, and 5.60% (33/589) were intramedullary, and 13.07% (77/589) were epidural. The pathological diagnoses included schwannoma (52.8%), meningioma (10.4%), cyst (8.0%), teratoma (24,4.1%), ependymoma (23,3.9%), and angioma (23,3.9%), and females had a higher incidence of meningiomas than males, with a male/female of 0.20. Pain, numbness, weakness, and sensory disturbances were most common presentations of the intraspinal tumor, which was determined partially by the vertebral level distribution and anatomical location.Conclusions: This large single-center clinical study adds new insights into the descriptive epidemiology and characters of primary intraspinal tumors by providing in-depth analyses of these tumors, which is of vital importance in planning studies on prevention, diagnosis, treatment, and prognosis of the tumors.