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Autoradiographic visualization of extrajunctional acetylcholine receptors in whole human biceps brachii muscle Changes in amyotrophic lateral sclerosis

ABSTRACT – The morphological distribution of acetylcholine receptors in the whole biceps brachii muscle from a patient with amyotrophic lateral sclerosis (ALS) and from a control patient was studied by in vitro autoradiography with 3H‐alpha‐bungarotoxin (alpha‐Btx). In ALS, 3H‐alpha‐Btx binding occurred over the entire muscle, while in the control case the binding was restricted to the motor end‐plate region.