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“Nonproductive” Mouse Sarcoma Virus Transformed Gorilla Cells which Contain Noninfectious Type C Virus Particles 1

Summary Gorilla spleen cells can be readily transformed morphologically in vitro by Kirsten murine sarcoma virus (Ki-MSV) and the MSV pseudotype of baboon placenta virus-MSV (BP). Gorilla spleen cells transformed in vitro by the MSV (BP) were found to be virus producers; whereas Ki-MSV transformed gorilla spleen cells were found to be nonproducer (NP). These NP cells were obtained by simply infecting gorilla cells with Ki-MSV and subculturing them. These morphologically altered NP cells did not produce infectious virus or murine leukemia virus gs antigen, but contained a rescuable MSV genome and also noninfectious type-C virus particles.