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An autoradiographic study of the binding of 3H‐chlorambucil to cells of a drug‐sensitive and drug‐resistant strain of the Yoshida ascites sarcoma

The binding of chlorambucil to drug‐sensitive and drug‐resistant Yoshida sarcoma cells has been investigated by an autoradiographic technique. The cells were treated with the drug at various concentrations both in vitro and in vivo. Using both light and electron microscope techniques, and by counting grains on various areas of the cell, the following conclusions were reached.