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Chicory root extracts reduce inflammation in vivo

Chicory (Cichorium intybus L.) contains sesquiterpene lactones, which are thought to be potent anti‐inflammatory agents. In this study, chicory extracts rich in sesquiterpene lactones significantly reduced inflammation in three animal models. In a rat paw edema model, chicory extract at 50 and 100 mg/kg significantly reduced inflammation by 58 and 76%, respectively, 24 h after carrageenan injection. In a collagen induced arthritis mouse model, chicory extract (200 mg/kg) reduced paw edema by 71% while the extract was being administered, and 31% 48 h after extract administration was discontinued. In a rat inflammatory bowel disease (IBD) model, chicory extract (300 mg/kg) reduced colon inflammation by 17% and also reduced ulceration and adhesions when IBD was induced using 2,4‐dinitrobenzene sulfonic acid (DNBS). A 28‐day rat toxicity study showed no signs of toxicity at doses up to 1000 mg/kg. These data demonstrate that chicory extracts rich in sesquiterpene lactones may be useful as a therapeutic agent for inflammatory disease.