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Cytogenetic abnormalities in serous papillary adenocarcinoma of the ovary.

PURPOSE OF INVESTIGATION
Epithelial ovarian tumors are usually mucinous or serous type, affecting nearly 1% of women during their lifetime. They may be regarded as benign, borderline or invasive according to pathological examination. Karyotypes of the tumor provide critical information about both the genetic predisposition and the stage of the tumor. We aimed to investigate the correlation between karyotype findings and the stage of the serous papillary tumors of the ovary.


METHODS
Tissue cultures were set up from 15 serous papillary adenocarcinoma samples of different stages and examined cytogenetically.


RESULTS
The most common chromosome abnormalities included both numerical and structural abnormalities of chromosomes 1, 3,6,7,8, 11, 21, 22 and X.


CONCLUSION
Karyotypes became more complex, as expected, with the later stages.