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Design of Far-red Fluorescent Kv1.3 Channel for Membrane Expression in Eukaryotic Cells and Its Interactions with Hongotoxin1

Potassium voltage-gated Kv1.3 channels found in many cell types of the nervous and immune systems control membrane potential and regulate a lot of cellular functions such as proliferation, migration, cytokine secretion, and apoptosis. Activity and elevated expression level of Kv1.3 channels mediate proinflammatory response in auto-immune disorders (rheumatoid arthritis, Type 1 diabetes, and asthma), and neuroinflammatory diseases (multiple sclerosis, ischemic stroke, Alzheimer's disease, and epilepsy) [1]. Inhibition of Kv1.3 channels activity in many cases resulted in the anti-inflammatory effect and is considered as a prospective therapeutic strategy. Peptide toxins from the scorpion venom with their ability to bind specifically and with high affinity to the target Kv1 channels represent a rich source of Kv1.3channel blockers and are considered as promising templates for drug development [2].