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Effects of Recombinant Human Interleukins on Food Intake of Previously Food-Deprived Rats

Abstract The effects of intracerebroventricular injection of recombinant human interleukin 1β (rhIL-1β), 1α (rhIL-1α), and 2 (rhIL-2) on feeding behavior were examined in previously food-deprived rats for 18 hr. At doses of 2–17 ng/rat, rhIL-1β significantly reduced food intake in a dose-dependent manner and the feeding suppression continued about 4 hr later. Only 17 ng/rat rhIL-1β reduced body weight gain for 8 hr after the injection. However, rhIL-1α at dose of 17 ng/rat did not show any significant change of food intake and body weight gain during the whole observation period. At both doses of 8 and 40 ng/rat, rhIL-2 also failed to suppress overfeeding after food deprivation. In adrenalectomized rats, feeding suppression by rhIL-1β appeared at the 1- to 2-hr time period. The present studies suggest that rhIL-1β may be, at least in part, involved in feeding suppression on various inflammatory processes and that adrenal hormones may not play an important role in the induction of feeding suppression by rhIL-1β.