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[Antigenic and immunoglobulin preparations for the diagnosis of coxiellosis in the system of conjugated unidirectional serologic reactions].

The methods for obtaining antigenic and immunoglobulin preparations intended for the rapid serological diagnosis of coxiellosis were developed. The cells used as the basis for their preparation were formulated tanned sheep red blood cells. As sensitin, rabbit anti-C.burnetii immunoglobulin was used. The capacity for the detection of C.burnetii antigens in the passive hemagglutination test and specific antibodies in the passive agglutination test with the use of the our immunoglobulin erythrocytic diagnosticum was studied. To construct coxiellosis antigenic erythrocytic diagnosticum, the complex of membrane antigens obtained from C.burnetii strain M-44 was used as sensitin. The positive results of the approbatory trial of the erythrocytic diagnosticums made it possible to recommend both preparations for use in laboratory practice in the system of conjugated unidirectional serological reactions.