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Effect of epinephrine in oil on susceptibility of x-irradiated rats to experimental bacterial endocarditis.

In previous studies it was shown that the susceptibility of rats to bacterial endocarditis can be greatly increased by the subcutaneous administration of large doses of epinephrine in oil [1] or by whole-body X-irradiation [2]. The histologic character of the lesions in the irradiated rats differed, however, from those in the nonirradiated rats. The purpose of the present investigation was to study the effect of a combination of epinephrine in oil and irradiation on the incidence, severity, and character of the lesions induced in rats by intravenous inoculation of Streptococcus mitis.