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Some Aspects of Localization of Tumours for Radiotherapy

gram whereas, of the 8 negative dissection cases, only 3 had had normal X-rays. The predicted situation is reversed! Secondly, we have studied 107 sets of X-rays of which 77 were considered normal and 30 showed filling defects. To date there has been no signicant difference in either groin recurrence or survival. We conclude that little notice should be taken of the lymphogram X-rays, whilst admitting that the small volume of Lipiodol used in this procedure makes diagnostic interpretation difficult. The crude survival rate of the 137 Stage I cases stands at 66% for five years and 76% for three years. To compare the figures with other series is meaningless as many were problem cases referred from elsewhere. We await with interest the results of the current Medical Research Council trial. Complications were few. Nine patients suffered burns of the skin from subcutaneous extravasation of isotope; most were no more than skin erythema with subsequent pigmentation; in one case the burn was excised and grafted. There were only 3 cases of permanent cedema of the leg. There were no pulmonary complications despite the inevitable occurrence of a small overspill into the lungs. Until the results of the Medical Research Council trial are available, the present policy of prophylactic intralymphatic isotope therapy for Stage I melanoma continues.