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Histocompatibility antigens in Parkinson's disease

The possible association of 7 HLA specificities in the HLA‐A locus and 16 specificities in the HLA‐B locus with susceptibility to Parkinsonian syndrome was investigated in a total of 36 patients with paralysis agitans (PA), as well as in 11 patients with other Parkinsonian syndromes, and 176 controls in Japan. There was no clear association between HLA‐A or ‐B locus antigens and PA or other Parkinsonian syndromes. Patients with PA were subdivided according to sex, age of onset, clinical manifestations, and response to L‐Dopa therapy. There was, however, no apparent association between HLA‐A or ‐B locus antigens and any of the variables investigated. Our data do not provide any evidence for genetic susceptibility in the pathogenesis of PA.