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Uptake of D‐serine by synaptosomal P2 fraction isolated from rat brain

We have demonstrated that the crude synaptosome P2 fraction prepared from the rat brain is able to accumulate [3H]D‐serine in a saturable, temperature‐dependent and partially sodium‐ and potassium‐dependent manner with an affinity of a hundred micromolar range. The inhibition profile of D‐serine accumulation by various amino acids is different from those of uptake systems reported for glycine and other amino acids. The present data suggest that the endogenous D‐serine may be taken up mainly through a carrier‐mediated transport system to regulate its extracellular concentration in the mammalian brain. Synapse 42:84–86, 2001. © 2001 Wiley‐Liss, Inc.