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A simple and convenient approach for evaluation of the parameters of ligand–receptor interaction. Receptor blocking index and its application

A new approach for determination of the parameters for ligand‐receptor interaction, which is based on so‐called dilution coordinates, was developed earlier. Equations that allow evaluation of not only the affinity of ligand‐receptor interaction but also of the amount of free (or occupied by corresponding ligand) receptors were suggested. The most important advantage of this approach as compared with well‐known methods is the ability to determine the binding parameters for ligand‐receptor interaction even for the cases in which ligand and receptor are already present in a mixture and separation of counterparts from each other is technically difficult or even impossible. Due to this reason, the proposed approach can be especially useful for studying interactions between highly‐labile biological receptors and corresponding ligands as found in vivo. In the present paper I continue to consider how to determine the binding parameters for a given ligand‐receptor interaction if the value of receptor blocking index is determined experimentally. Copyright © 2008 John Wiley & Sons, Ltd.