{'fraction_non_alphanumeric': 0.04529616724738676, 'fraction_numerical': 0.029036004645760744, 'mean_word_length': 4.4525316455696204, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Cardiac function, coronary flow, and oxygen consumption in stable left ventricular hypertrophy.

MALIK,ASRAR B., TOMIO ABE,HUGH O'KANE, AND ALEXANDER S. GEHA. Cardiac function, coronary flow, and oxygen consumption in stable left ventricular hypertrophy. Am. J. Physiol. 225( 1) : 185-191. 1973.-We have compared cardiac function, coronary flow, and oxygen consumption of the canine left ventricle in stable hypertrophy (LVH) with those of the normal left ventricle (N). LVH was produced by banding the ascending aorta early in life. Nine dogs with LVH and 13 normal dogs were anesthetized with 30 mg/kg sodium pentobarbital. Coronary flow to the left ventricle (QLv) was measured electromagnetically, cardiac output (Q) was measured by the dye-dilution technique, and pressures were monitored in the aorta and left ventricle. Oxygen contents of the arterial and LV effluent blood were determined and LV oxygen consumption (~LvO~) was calculated using the Fick equation. The results indicate that various indices of left ventricular function such as a, minute work, stroke work, external mechanical efficiency, peak LVdP/dt, ratio of peak LVdP/dt to LVEDP, and ratio of peak LVdP/dt to isovolumic pressure were in the normal or above-normal range in LVH. However, the mean QLV of 74 =t 12 ml/min per 100 g LV wt in LVH was significantly lower than 101 =t 8 ml/min per 100 g LV wt in N as a result of a decreased flow in late systole, probably due to increased myocardial systolic compression. Despite the lower mean QLV in LVH, ~LvO~ was maintained at normal levels (9.40 zt 1.60 ml/min per 100 g LV wt in N and 9.13 =t 1.75 ml/min per 100 g LV wt in LVH) through greater oxygen extraction by the hypertrophied myocardium.