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[The effect of complete Freund adjuvant on the development of bladder tumor induced by N-butyl-N-(4-hydroxybutyl) nitrosamine].

To study the mechanism of prohibition for the reccurence of bladder tumors by intravesical Bacillus Clamette-Guerin (BCG) treatment, we made a mice system using Freund Complete Adjuvant (FCA) as an immunoactivator and N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) as a carcinogen. C57BL/6 mice mice were treated with BBN and FCA simultaneously, and it was found that the FCA treated group revealed a significantly lowered number of piled layer (NPL) in the bladder epithelium. The FCA which is composed of Bacillus Clamette-Guerin and mineral oil is used to enhance the immune activity in several system. The result obtained in this experiment seemed correlated with the clinical effiency of intravesical BCG treatment to prohibit the reccurence of superficial bladder carcinoma. The result and the resistance of MRL/lpr mice to BBN treatment give us an idea the presence of hyperimmune state at the early phase of development to malignant change is a factor to protect the host from carcinoma. But when we increase the number of FCA treatment, the NPL values also increased, which gave us a caution to dettermine the dose and number of BCG treatment in the patient. We suspect the efficiency of BCG may be something like chemopreventing agents (Retinoid etc.), but further experiment is necessary to comfirm it.