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[Effect of dimephosphon and xydiphone on mineral metabolism and lipid peroxidation in rats subjected to "pulse-therapy" with prednisolone].

The parameters of mineral metabolism, a lipid peroxidation (LPO) process, and the efficacy of antioxidant enzyme preparations were studied in rats with an osteoporosis model induced by the administration of prednisolone in a daily dose of 100 mg/kg (i.p.) over 3 days, which is analogous to a pulsed therapy schedule in clinics. The treatment with glucocorticosteroid enhanced the excretion of hydroxyproline and inorganic phosphates with urine, increased the LPO rate and antioxidant activity of the blood serum, and decreases the level of ceruloplasmin and the catalase activity in the blood. A prophylactic treatment with dimephosphon (208 mg/kg, p.o.) and xydiphone (45 mg/kg, p.o.) prevents from the prednisolone-induced LPO activation. Dimephosphon, in contrast to xydiphone, also prevents from a prednisolone-induced increase in the excretion of hydroxyproline and inorganic phosphates with urine.