{'fraction_non_alphanumeric': 0.022727272727272728, 'fraction_numerical': 0.015495867768595042, 'mean_word_length': 5.591836734693878, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Hypertension-induced alarm signal

Immunology
Human hypertension is a highly prevalent disease known to be associated with chronic low-grade inflammation. Zhao et al. used mouse models to look for hypertension-induced proinflammatory molecules that contribute to T cell activation and inflammation. They found consistent elevations in plasma levels of the alarmin molecule adenosine triphosphate in hypertensive mice. Increased adenosine triphosphate (ATP) concentrations promoted T cell responses by enhancing expression of the CD86 costimulatory molecule on antigen-presenting cells, an effect mediated through the P2X7 purinergic receptor. Elevations of plasma ATP were also detected in a cohort of hypertensive human patients when compared with normotensive controls. Thus, ATP release and the ATP-P2X7 signaling axis represent potential targets to help rein in the proinflammatory sequelae associated with chronic hypertension.

Sci. Immunol. 4 , eaau6426 (2019).