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Rational drug design and resistance in chronic myelogenous leukemia

BCR-ABL. These initial experiments revealed two resistance mechanisms: The aim of this bibliographic revision is to describe the process of development of TKIs, specially emphasizing on the idea of rational anti-cancer drug design as the main strategy for overcoming resistance to therapy. I also pretend to review the actual situation of CML thanks to TKIs, an example of how biochemistry and molecular pathology can highly improve medicine.