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Opto-Thermo-Electrohydrodynamic Tweezers: Towards On-chip Single-Molecule Trapping and Analysis

The trapping and dynamic manipulation of nanoscale biological molecules such as proteins and exosomes using the conventional optical tweezer technology have been met with challenges. This arises because of the substantial optical intensity required, which poses photo-induced damage to the biomolecules. In this talk, I will introduce a new kind of optically controlled nanotweezers termed Opto-Thermo-Electrohydrodynamic Tweezers (OTET) that enables the stable trapping and dynamic manipulation of sub-10 nm biomolecules at locations that are several microns away from the high-intensity laser focus, where they experience both negligible photothermal heating and light intensity. 
This novel non-invasive optical nanotweezer is expected to open new horizons in life science and medicine by offering an unprecedented level of control of tiny nano-sized biological objects in solution without photo-induced damage.