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The qualitative and quantitative analysis of 8‐methoxypsoralen by HPLC‐UV and GLC‐MS

Introduction The photosensitizing psoralens (furocoumarines) are increasingly used for treatment of a variety of skin disorders (see Gazith & Schaefer, 1977 for references), but little information has been available until recently on the pharmacokinetic and biochemical properties of these compounds in man. Lack of suitably sensitive and specific analytical procedures for the psoralens has been the major difficulty. Gas-liquid chromatography with flame ionization detection (GLC-FID) (Gazith & Schaefer, 1977), high pressure liquid chromatography with ultraviolet detection (HPLC-UV) (Thune & Volden, 1977; Thune, 1978; Puglisi, de Silva & Mayer, 1977) and thin layer chromatography with photodensitometric detection (Steiner et al, 1978) have all recently been applied to the analysis of 8-methoxypsoralen (8-MOP) in human plasma and serum. Although these techniques have already been described, it was necessary to develop an additional and probably more selective analytical method, namely gas-liquid chromatography with mass spectrometric detection (GLC-MS). Furthermore the absence of any published data on metabolites of 8-methoxypsoralen in man which might interfere with any of the above analytical techniques required that a comparison of the results obtained by GLC-MS be made with those of another analytical technique, namely HPLC-UV.