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The mechanism of fluoride protection.

Since the 1940s, researchers have understood the positive effect of fluoride on anticaries activity. Several studies, beginning with the Cheektowaga study, showed that an increased number of concentrated fluoride applications also have a beneficial effect on anticaries activity. In fact, the continuous presence of high-fluoride concentrations has a more significant protective effect than enamel fluoride. A high-potency dentifrice is the ideal form with which to produce protective effects. This article describes how high-fluoride concentrations affect dental caries.