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[Patterns of the directed biosynthesis of trichothecin and fibrinolytic enzymes in Trichothecium roseum].

The production of the antibiotic trichothecin and of fibrinolytic enzymes was studied in the culture of the fungus Trichothecium roseum. Correlations were established between the parameters for the biosynthesis of trichothecin and fibrinolytic enzymes and the growth rate of the fungus. Thease as well as certain ratios found between potassium nitrate and ammonium chloride in the growth medium made it possible to use the function of desirability and to synthesize preferentially either trichothecin or fibrinolytic enzymes in the culture. An approach has been suggested for passing from the measurable parameters of the biosynthetic process to conventional values of desirability.