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[Inhibitory effects of nitric oxide and atrial natriuretic peptide on the increase in renal afferent nerve activity induced by intrarenal arterial injection of ET-1 in anesthetized rats].

AIM AND METHODS
By using electrophysiological technique, the effects of nitric oxide (NO) and atrial natriuretic peptide (ANP) on renal afferent nerve activity (RANA) induced by intrarenal arterial injection of endothelin-1(ET-1) were examined in anesthetized rat.


RESULTS
(1) In response to intrarenal arterial injection of ET-1 (1 microg/kg) MAP was initially decreased and subsequently increased, and RANA was increased to 208.33 +/- 16.60% (P < 0.001). (2) Pretreatment with L-Arg or ANP could effectively inhibit the above biological actions induced by ET-1.


CONCLUSION
Intrarenal arterial injection of ET-1 can markedly induce the increase in RANA, an effect which is abolished by L-arg or ANP administered by the same route.