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[Study on expression of disaccharide residue and its significance in lung cancer tissues.].

BACKGROUND
To study the expression of disaccharide residu (D-Galactose-beta-(1v3)-N-Acetyl- galactosamine) in lung cancer.


METHODS
Surgical dissected samples from 109 cases of lung cancer and 87 cases of lung benign diseases were fixed in 4 % formaldehyde and embeded in parafin. Disaccharide residue was examined by galactose oxidase-Schiff's method.


RESULTS
The positive rate of bronchial submucous glands from patients with lung cancer was 71. 76 %(61/ 85) , and the positive rate of bronchial submucous gland from patients with benign pulmonary diseases was 71. 83 %(51/ 71) . There was no significant difference between two groups (Chi-Square = 0. 0026 , P > 0. 9) . Among 94 cases of lung cancer tissues , the positive rate of adenocarcinoma was 36. 11 %(13/ 36) , and the other lung cancer were negative reaction.


CONCLUSIONS
The study showed that disaccharide residue was expressed in submucous glands of bronchial submuca in both patients with pulmonary benign or malignant diseases , and only expressed in partial adenocarcinoma tissues among the pulmonary carcinoma. It has not enough evidence to differentiate benign from malignant diseases of lung.