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Brief Computer‐Based Information Processing Measures are Linked to White Matter Integrity in Pediatric‐Onset Multiple Sclerosis

Pediatric‐onset multiple sclerosis (POMS) is a demyelinating disorder with unique clinical challenges. A brief computer‐administered cognitive screening battery measuring processing speed (Cogstate) and the Brief International Cognitive Assessment in MS (BICAMS) detect cognitive impairment in POMS. The neuroanatomic correlates of these deficits are incompletely understood. The purpose of this study is to define the neuroanatomic underpinnings of deficits identified with cognitive screening batteries in POMS.