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Coagulation factor II thrombin receptor like 2 (F2RL2) is differentially expressed in brain metastatic breast cancer.

Breast cancer patients diagnosed with metastasis to the brain (1-3) are presented limited treatment options (4, 5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in human breast cancer, and identified differential expression of the gene encoding the coagulation factor II thrombin receptor like 2, F2RL2, when comparing brain metastatic tissues to primary tumors of the breast. F2RL2 was expressed at significantly lower levels in metastasis to the brain as compared to primary tumors. Thus, a receptor for a coagulation factor appears to be among the most significant transcriptional features of brain metastasis in patients with breast cancer; functions and down-regulation of F2RL2 may be relevant to pathways underlying metastasis to the brain in human breast cancer.