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ANTI- INFLAMMATORY ACTIVITY OF VITEX TRIFOLIA LINN. (VERBANEACEAE) LEAVES EXTRACTS

Objectives: The present study was carried out to evaluate the antiinflammatory effect of extracts of leaves of Vitex trifolia Linn. (Verbaneaceae). Methods: The anti inflammatory activity of plant extracts at different dose intervals was evaluated by using two models Carrageenan induced rat paw edema and Xylene induced ear edema in Mice. Acute inflammation in rats was induced by injecting Carrageenan (0.1 ml of 1% suspension in 0.9% saline) in subplantar region and topical application of xylene (0.03ml)to the anterior and posterior surface of mice ear. The mean paw volume and percent reduction in ear edema were evaluated. Results: Significant reduction in Paw volume (P<0.01) and ear edema were observed in all treated groups. Alcoholic extract showed more activity than aqueous extract and also in dose dependent manner. Conclusion: The study showed that the leaves of Vitex trifolia Linn. (Verbaneaceae) possess an anti-inflammatory activity.