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ROLE OF ARACHIDONIC ACID METABOLITES (AAM) IN HEMODYNAMIC and HEMATOLOGIC MANIFESTATION OF GROUND B STREPTOCOCCAL (STREP) SEPSIS

Although STREP-induced shock appears to be modulated by AAM, the importance of the AAM in mediating neutropenia and thrombo-cytopenia and the role of neutropenia and thrombocytopenia in development of shock is unknown. To assess these relationships in rabbits, the changes from baseline (BASE) in mean arterial pressure (MAP), neutrophil (NT) and platelet count (PLT) were correlated with changes in thromboxane B2 (TB), prostacyclin metabolite 6KPGF1α (6K) and 5-HETE, a lipoxygenase metabolite following heat-killed STREP (1012 cells/kg) infusion before and after prostaglandin (PG) inhibition with indomethacin (IND) (4 mg/kg). The table shows modulation of STREP effects by IND when given before (GpII) and after (GpI) STREP. Values are [Xmacr ] ±SEM. *=P<0.05 vs BASE.IND did not inhibit STREP-induced increases in 5-HETE production. This study shows 1) that STREP shock is dependent on PG formation but independent of the 5-lipoxygenase pathway, and 2) thrombocytopenia and neutropenia are independent of shock or PG synthesis.