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Prediction of Protein – Protein Interactions Using Evolutionary and Structural Relationships

One of the central problems in modern biology is to identify the complete set of interactions among the proteins in a cell. The structural interaction of proteins and their domains in networks is one of the most basic molecular mechanisms for biological cells, and structural evidence indicates that, interacting pairs of close homologs usually interact in the same way. In this article, we make use of both evolutionary and structural relationships to predict interaction between protein pairs solely by amino acid sequence information. High quality core set of 150 yeast proteins obtained from the Database of Interacting Proteins (DIP) was considered to test the accuracy of the proposed method. The strongest prediction of the method reached over 70% accuracy. These results show great potential for the proposed method.