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Protective Effect of Lycopene against Genotoxicity of Nickel Sulfate in Rats

Aim: Nickel, which has a wide usage area in industries, has teratogenic, carcinogenic, immunotoxic, and genotoxic effects. In this study, the protective effects of lycopene, which has antioxidant properties, were investigated against genotoxicity caused by nickel sulfate. Materials and Methods: In the study, a total of 24 rats (Wistar albino) were divided into four groups: Group I (control) daily by saline intraperitoneal (i.p.) and corn oil oral gavage (0.5 ml); Group II nickel sulfate (20 mg/kg, i.p.) was dissolved in physiological saline; Group III lycopene corn oil (0.5 ml) was suspended by oral gavage at 20 mg/kg doses; Group IV lycopene was suspended in corn oil (0.5 ml) and given by oral gavage at 20 mg/kg doses, 2 hours later, nickel sulfate (20 mg/kg, i.p.) was administered for 21 days. Micronucleated polychromatic erythrocytes (MNPCE) and polychromatic erythrocytes (PCE) were examined by bone marrow micronucleus test, which is one of the genotoxicity tests. Results: It was determined that the administration of lycopene for preventive purposes decreased the MNPCE levels significantly (p