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1324-P: Glucose Metabolism among Obese and Nonobese Children of Mothers with Gestational Diabetes

Abdominal obesity is more closely associated with diabetes than general obesity in adults, however, it is unknown which kind of obesity is more closely associated with abnormal glucose metabolism in children. We recruited 973 children of mothers with prior gestational diabetes mellitus (GDM). Children’s height, weight, waist circumstance, fasting glucose and insulin were measured using standardized methods. Logistic regression models were used to assess the single and joint associations of general and abdominal obesity with the risks of hyperglycemia (the upper quartile of fasting glucose), insulin resistance (the upper quartile of HOMA-IR), and β-cell dysfunction (the lower quartile of HOMA-% β). Compared with normal weight children, children with general overweight/obesity had higher levels of HOMA-IR and HOMA-%β, higher odds ratios for hyperglycemia (1.56, 95% confidence intervals [CIs] 1.06-2.30) and insulin resistance (3.44, 95% CI 2.32-5.09), and a lower odds ratio for β-cell dysfunction (0.65, 95% CI 0.41-1.04). Children with abdominal obesity had increased insulin resistance (2.54, 95% CI 1.71-3.76) but not hyperglycemia and β-cell dysfunction compared with normal weight children. In the joint analyses, children with general overweight only or with both general and abdominal obesity but not with abdominal obesity only had increased hyperglycemia and insulin resistance compared with normal weight children. General obesity was more closely associated with major abnormal glucose metabolism than abdominal obesity in children of mothers with GDM. Disclosure J. Lu: None. Y. Gu: None. L. Wang: None. W. Li: None. S. Zhang: None. H. Liu: None. J. Leng: None. J. Liu: None. S. Wang: None. L. Hou: None. A. Baccarelli: None. G. Hu: None. Funding Tianjin Women’s and Children’s Health Center; Tianjin Public Health Bureau; European Foundation for the Study of Diabetes/Chinese Diabetes Society; Lilly Program for Collaborative Research between China and Europe; National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100790 to G.H.); National Institute of General Medical Sciences (U54GM104940 to G.H.)