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FDG-PET Scanning : Cancer of the Oesophagus HRT : Have We Changed ?

Background B-type natriuretic peptide (BNP) is widely accepted in the evaluation of left ventricular systolic dysfunction and heart failure. However, little is known of the implications of elevated BNP levels in individuals with preserved systolic function (PSF). Aims To investigate the drivers and clinical implications of elevated BNP levels in asymptomatic individuals with established PSF. Methods We enrolled 154 individuals who all underwent physical examination, BNP evaluation and Doppler-echocardiographic studies. They were divided into those above and below the median BNP level (50pg/ml). Results Independent predictors of higher BNP were older age, more severe left ventricular hypertrophy (LVH), reduced E/A ratio and ischaemic heart disease. Survival and multivariable analysis demonstrated more death and/or admission in those above the median BNP (HR: 4.79, p=0.007). Conclusions Elevated BNP is the strongest, independent predictor of serious adverse cardiovascular outcomes in this population and requires closer clinical follow-up. S Karuppiah, F Graham, M Ledwidge, C Conlon, J Cahill, C O’Loughlin, J McManus, K McDonald Heart Failure Unit, St Vincent’s University Hospital, Dublin and *Carlton Clinic, Bray ELEvAtEd BNP wIth NORMAL systOLIC fuNCtION IN AsyMPtOMAtIC INdIvIduALs At-RIsk fOR hEARt fAILuRE: A MARkER Of dIAstOLIC dysfuNCtION ANd CLINICAL RIsk Springer and the Royal Academy of Medicine of Ireland enter into publishing partnership Irish Journal of Medical Science added to growing medical portfolio London/New York, 17 November 2006 Springer, one of the world’s leading scientific publishers, has announced a partnership with the Royal Academy of Medicine of Ireland (RAMI) to publish their journal, the Irish Journal of Medical Science (IJMS), starting in 2007. The addition of this journal to Springer’s portfolio accentuates its growing strength in medical publishing. Established in 1832, the Irish Journal of Medical Science is one of the first and foremost scientific journals in the Anglo-Celtic islands. With articles written by international specialists, it covers all branches of medicine and publishes papers relevant to the daily practice of the medical professional. IJMS will be published quarterly and will contain reviews, original articles and commentaries. The Editor-inChief is Professor David Bouchier-Hayes, a surgeon with a strong reputation in Ireland and internationally. Dr. Fergus O’Kelly, President of the RAMI, said, “This is an exciting and most important time for the Royal Academy of Medicine of Ireland and its official organ, the Irish Journal of Medical Science. The Executive Board of the Royal Academy is most positive about our association with Springer.” Dr. John O’Connor, General Secretary, continued, “We look forward to this partnership and the many benefits that Springer’s publishing experience will bring to the journal.” Christiane Notarmarco, Executive Editor at Springer London, echoed their sentiments, “We are proud to be associated with such a respected and historic body as the RAMI and are delighted to be supporting their mission. Through global distribution and electronic publishing on SpringerLink, IJMS will continue to grow.” Springer will publish the Irish Journal of Medical Science in both electronic and print formats to serve the needs of librarians and readers around the world. The journal will be available via SpringerLink, Springer’s fully integrated, online information platform. Both Online FirstTM, a feature where articles are published online before they appear in print, and Editorial Manager, an online peer review and author submission system, will be fully implemented for the journal. The Springer Open Choice program offers all potential IJMS authors the option of publishing their articles using the open access model once they have been accepted for publication.