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[Complex morpho-functional characteristic of adrenal medulla and cardiac sino-auricular area in dogs after 30 day hypokinesia].

The aim of this study was to characterize tissue components of adrenal medulla and cardiac sino-auricular area in dogs exposed to hypokinesia for 30 days. The material was studied using the methods of light and electron microscopy. The quantitative and qualitative morphological features indicative of high functional activity of both structures were detected at tissue, cellular and subcellular level. Cardiomyocytes in the sino-auricular area demonstrated the reactive changes of energy-producing apparatus and membrane systems, responsible for ion exchange, while myofibrils remained intact. It is concluded that after 30-day hypokinesia adrenomedullary secretory activity was markedly increased, which in association with an increased chronotropic function of the heart may cause negative changes in contractile and conducting cardiomyocytes of sino-auricular area.