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Effect of Ambroxol Hydrochloride on Pulmonary Surfactant of Elderly Patients Undergone Off-Pump Coronary Artery Bypass Grafting

Objective:To investigate the effect of ambroxol hydrochloride on pulmonary surfactant(PS) of elderly patients undergone off-pump coronary artery bypass grafting.Method:50 cases of patients(at the age of 65-75)were collected to line OPCABG,randomly divided into control group and treatment group(each of 25 cases).Patients in control group were treated with 0.9% Na Cl al one(10 m L,iv,q8 h,qdx3, preoperatively and postoperative), while those in treatment group received 30 mg ambroxol hydrochloride(iv,q8 h,qdx3, preoperatively and postoperative).Right broncho-alreolar lavage(BAL)was carried out after intubation preoperatively, postoperative and before removal of the cannula.Total phospholipid(TPL),saturated phosphaytidylcholine(Sat PC)and total priotin(TP) in the BALF were measured.The ratio of Sat PC/ TPL and Sat PC/ TP represented the activity of PS.Result:Compared with preoperation, Sat PC/TPL and Sat PC/TP of two groups decreased at a certain extent postoperatively.The treatment group was better than the control group, there was statistical significance, preoperatively, postoperative and before removal of the cannula.Conclusion:Ambroxol hydrochloride can promote the synthesis and secretion of PS in elderly patients undergone OPCABG, prevent the PS down, so as to improve the pulmonary function of patients after operation.