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Study on histological classification and immunohistochemical expression in dermatofibrosarcoma protuberans

Objective To investigate the relationship between histological classification and immunohistochemical expression in dermatofibrosarcoma protuberans(DFSP). Methods 42 DFSP cases were analysed by clinical pathology with HE stain and S P immunohistochemistry.Results 42 cases were classified into conventional, fibrosarcoma lesion, myxoid and melanin pigmented DFSP. CD34 was stablely positive in each subtype DFSP while Vimentin was weak positive, and sometimes unstable; nm23, Ki 67, p53 expression had no statistical difference among the subtype. Conclusion Conventional DFSP is a low grade malignant neoplasm while fibrosarcoma lesion DFSP is more malignant; myxoid and melanin pigmented DFSP would be further to investigate. CD34 is positive and very characteristic for diagnosis and identification of DFSP.