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[Role of genetic factors in development of occupational obstructive lung disease].

The authors represent associative study of 180 patients having chronic obstructive lung disease 1-2 stages, who exposed at work to industrial pollutants (58.3% exposed to moderately fibrogenous dust and 41.7%--to a complex of aromatic organic solvents). Findings are increased (p < 0.05) concentration of IL-1beta in individuals exposed to chemicals, when compared to those exposed to dust at work. Relation was seen between transforming growth factor beta1 (rs1804470 of TGFB1 gene) and rs1828591 of HHIP gene with propensity to COLD formation. Genotype AA and AG demonstrated protective effect against the disease.