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The effect of acidosis on pulmonary vascular smooth muscle cell metabolic response to hypoxia: implications for Pulmonary Hypertension

A glycolytic shift is key to apoptotic resistance in cancer cells and pulmonary vascular smooth muscle cells in pulmonary hypertension (PH). Its reversal may lead to apoptosis and reverse pulmonary vascular remodeling. We found that acidosis reversed remodeling in experimental PH and sought to investigate the metabolic response of pulmonary artery smooth muscle cells (PASMCs) to hypoxia.