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The behaviour of the keratinizing epithelium in tympanoplasty

Experimental observations on animals suggest that a tympanic graft acts as a scaffold for the epithelium spreading from the margin of a perforation. Epithelial growth and fibrosis appear to compete with the tendency to necrosis of the graft (Reynen and Kuypers, 1971; Marquet et al., 1973). Fresh fascia grafts show early autolysis and are quickly resorbed. Fascia or tympanic homografts preserved in formaldehyde, however, conserve their structure much longer and break down more slowly (Kuypers and Van den Broek, 1975; Boedts, 1978).