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Influence of Cystic Fibrotic and Heterozygous Serum on Rat Jejunum 1

Summary The rat jejunum bioassay has been shown to be capable of identifying both the cystic fibrotic homozygote and heterozygote and therefore would appear to have great potential as a screening test for the latter. It is suggested that the cystic fibrosis factor does not influence sodium reabsorption by inhibiting an active sodium reabsorption mechanism but rather by inhibiting passive sodium entry into the cell.