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A strategy for the contrast enhancement of malignant tumors using dynamic computed tomography and intravascular pharmacokinetics.

Sequential dynamic computed tomographic (CT) body scans were performed during administration of diatrizoate (intravascular bolus and infusion) in 18 cancer patients, three patients with cysts, and four rabbits with V2 carcinoma. The best diagnostic images occurred soon after the bolus was given (within 60--90 sec.). Tumors and normal tissue became isodense with drip infusions and on delayed scans. Tumors had increased CT numbers (mean, 29.2; range, 11--64); unchanging CT numbers helped identify cysts. Three cancer patients were scanned after both intravenous and intra-arterial injection of contrast media. Contrast enhancement and cancer CT numbers were highest after intra-arterial administration.