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[Human papillomavirus -- the major infectious factor in the process of cervical intraepithelial neoplasia].

In spite of increasing knowledge concerning cervical cancer; and the documented role of Human Papilloma Virus (HPV) -- as a major causing factor; there have been no changes in the epidemiological situation of this disease, especially in our country. Cytological screening has made crucial impact on decreasing mortality in that carcinoma. HPV involvement in cervical neoplasia and new diagnostic methods give possibility for early diagnosis of cervical lesions and to identify the group of women with higher risk of cervical cancer. Nevertheless there are no strict recommendations concerning HPV diagnostic procedures especially in the mass screening programmes. Therapeutic methods, specifically for HPV infection are still unknown. Based on the above, questions arise, if it is medically and financially justifiable to detect HPV infection? What is the clinical algorithm for the management of infected patient? And what is the future treatment?