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Pregnancy and corneal allograft rejection.

We describe late-onset, recurrent, bilateral allograft rejection episodes in a patient with keratoconus during pregnancy and shortly after giving birth. Graft patients should be aware of the possibility of rejection episodes during and after pregnancy even many years after undergoing penetrating keratoplasty. Report of a Case. A 31-year-old white woman with a history of keratoconus in both eyes underwent a penetrating keratoplasty in her left eye in 1972 and in her right eye in 1974. She underwent a regrafting in the left eye in 1988. This surgery was performed as part of the Collaborative Corneal Transplant Study. In 1994, 3 weeks after giving birth, she experienced blurred vision in her right eye. On ocular examination, she had a best-corrected visual acuity of 20/50+2 OD and 20/30−2 OS. In her right cornea, she had stromal edema (2+), folds in the Descemet membrane, and inferior keratic precipitates. She had a central endothelial