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Albumin-containing solutions equalize quantum yields of porphyrinic photosensitizers

Fluorescent and singlet oxygen quantum yields of chlorin-based photosensitizer PhotoditazinTM were compared with those of porphyrin-based preparations in the environment of phosphate buffer and albumin. The albumin addition reduced both fluorescence and sensitizing properties of all the agents under study, equalizing quantum yield values of chlorin-based and porphyrin-based preparations. Complex formation between albumin and agent molecules was supposed to be the reason of the effect.