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Stimulation of Pneumocystis carinii Encystment Following Necropsy

The cyst is an integral life cycle stage of Pnewnocystis carinii (P. carinii) [4]. The stimulating signal that triggers encystment is not known, but has been proposed that crowding or diminished energy supply may favor conversion to this more rigid form. A rat model of P. carinii pneumonia was utilized to determine if a change in environment will induce encystment; specifically, whether there is an increase in cyst number in infected lungs after the lungs are removed from the host animal.