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Genetic control of chromosone stability in the yeast Saccharomyces cerevisiae

We have identified four new genetic loci: CHL2 (on chromosome XII) CHL3 (on chromosomes XII); CHL4 (on chrosomes IV), and CHL5 (on chromosomes IX), controlling mitotic transmission of yeast chromosomes. The frequency of loss of chromosomes is 10–100‐fold in chl5, chl2, chl3 and chl4 mutants than observed in wild‐type strains. The mutants also unstable maintenance of artifcial circular minichromosomes with various chromosomal replicators (ARS) and one of the concentrations loci (CEN3, CEN4, CEN5, or CEN6). The instability of minichrosomes in the chl5, chl2, and chl4 mutants id due to the loss of minichromosomes in mitosis (1 : 0 segregation). In the chl3 mutant the instability of artificial minichromosomes is due to nondisjunction (2 : 0 segregation). The CHL3 gene therfre appears to affect the segregation of chromosomes during cell division.