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Adenocarcinoma of unknown origin in a patient with primary intestinal lymphangiectasia.

To the Editor: Immunosuppressed patients are prone to the development of neoplasia (1). Because of the changes in immunological reactivity in intestinal lymphangiectasia (IL) a higher than expected incidence of malignant neoplasms would be presumed to occur in patients with IL. However, only a few clinical reports refer to neoplasms in IL, We report a patient who developed an adenocarcinoma of an unknown origin 5 years after the diagnosis of IL. The relationships between primary IL, immunodeficiency, and malignancy are discussed.