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Design of Radiation Crosslinked Psyllium and Binary Monomers-Based Hydrogels for Use in Colon Drug Delivery

The present paper deals with the utilization of the cancer-lowering dietary fiber psyllium, for the development of double potential hydrogels meant for colon cancer drug delivery. The psyllium-acrylamide (AAm)-acrylic acid (AAc)-based hydrogels were synthesized by the radiation method and were characterized with FTIR, SEMs, and swelling behavior. Swelling and drug release mechanism were evaluated. The maximum water uptake (18.968 ± 0.880)g and (9.976 ± 0.364) g/g of gel were observed in solution of pH 7.4 buffer and solution of pH 2.2 buffer. respectively. The release of drug from the polymer matrix occurred through a Fickian-type diffusion mechanism.