{'fraction_non_alphanumeric': 0.04446546830652791, 'fraction_numerical': 0.003784295175023652, 'mean_word_length': 6.053333333333334, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
EFFECTS OF ANTICONVULSANT AND CONVULSANT DRUGS ON THE ATPASE ACTIVITIES OF SYNAPTOSOMES AND THEIR COMPONENTS

1 The effects of anticonvulsants, and other drugs on the Na+, K+‐adenosine triphosphatase (ATPase) (ouabain‐sensitive) and Mg++‐ATPase activities of synaptosomes and their components have been determined. 2 The Mg++‐ATPase activity of synaptosomes was not affected by the drugs but the Na+, K+‐ATPase activity was inhibited by phenytoin (diphenylhydantoin), ethosuximide and diazepam. 3 Fractions containing mainly membranes, mitochondria or synaptic vesicles, were prepared from synaptosomes by osmotic shock and subsequent density gradient centrifugation. Inhibition of Na+, K+‐ATPase activity by phenytoin, ethosuximide and diazepam was apparent only in the membrane fraction. 4 The fraction containing synaptic vesicles exhibited pronounced Mg++‐ATPase but no Na+, K+‐ATPase activity. In contrast to the enzymes of the membranes and mitochondria, the Mg++‐ATPase of the vesicles was inhibited by diazepam and all of the anticonvulsants tested.