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The CDKAL1 gene is associated with impaired insulin secretion and glucose‐related traits: the Cardiometabolic Risk in Chinese (CRC) study

Insulin secretion and insulin resistance, which affect metabolic homoeostasis, each have a significant genetic component. Cyclin‐ dependent kinase 5 (CDK5) regulatory subunit‐associated protein 1‐like 1 (CDKAL1) rs10946398, a novel body mass index (BMI)‐associated locus specifically in the Asian population, may impair insulin secretion and may be associated with insulin resistance and type 2 diabetes. Our objective was to investigate the impact of the rs10946398 polymorphism of CDKAL1 on insulin secretion, insulin resistance and glucose‐related traits in the Chinese population.