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Gout and its relation to lipid metabolism. I. Serum uric acid, lipid, and lipoprotein levels in gout.

The relation between uric acid and lipid metabolism has been the subject of various recent studies. HarrisJones (1957) reported that the serum uric acid level was often elevated in patients with essential hyperlipoproteinemia. Strejcek and Kucerova' (1968) demonstrated the incidence of gout in patients with high serum lipid levels, and thesamephenomenon was observed by Berkowitz (1964), Feldman and Wallace (1964), Barlow (1966), Benedek (1967), Gunther, Herbst, and Knapp (1967) and Darlington and Scott (1972). Investigations in which all the serum lipids and lipoproteins are determined in patients with gout and a control group are rare. This paper reports the levels of serum uric acid, triglycerides, free-fatty acids (FFA), phospholipids, and total cholesterol in patients with gout and in a control group, with a comparison of the lipoprotein fractions of both groups.