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Bifenthrin Induces Fat Deposition by Improving Fatty Acid Uptake and Inhibiting Lipolysis in Mice.

Chemical residues in the environment are considered to be important factors that cause obesity. Bifenthrin is one of the pyrethroid pesticides and is widely used worldwide. However, its effect on adipose tissue is ill defined. Here, we administered bifenthrin/corn oil to adult C57BL/6 mice by gavage. After six weeks, the bifenthrin treatment significantly increased body weight (P = 0.015) and fat mass (P < 0.001). Then, we identified 246 differently expressed proteins by proteomic analysis and they highly involved in fatty acid uptake and lipid metabolism process. Interestingly, protein hormone-sensitive lipase (HSL) and adipose triacylglyceride lipase (ATGL) were down-regulated while lipoprotein lipase (LPL) is up-regulated after bifenthrin treatment. Similar effects in 3T3-L1 cells treated with bifenthrin validated the in vivo results. Thus, this study suggests that long-term exposure to low-dose bifenthrin induces fat deposition in mice by improving fatty acid uptake and inhibiting lipolysis, and it may cause obesity in human.