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Studies on contact activation after heparin application on patients undergoing end-prosthetic hip implantation and hip replacement

Within the context of the present study an investigation on the physiology of clotting was conducted in three groups each consisting of 12 patients, who had to undergo a total end-prosthetic hip implantation (TEPH) for the first time. For all three patient groups an activation of both systems was to be observed with the TEPH-implantation, but there were no statistically striking differences between the three groups. Thus in the case of the kallikrein-like activity an intraoperative rise of over 37% was registered, while at the same point in time there was only a 4% reduction in the prekallikrein activity. Postoperatively a 10% rise in the prekallikrein activity was observed.