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Nonesterified fatty acids: role in the molecular events linking endocrinology and oncology via nutrition.

It is more and more clear from recent studies that both steroid and peptide (hormone and growth factor)-mediated pathways of mitogenesis are closely linked. These two pathways are intertwined into a highly regulated network. The two main points of connection are at the level of lipase and protease biosynthesis and regulating systems. Both enzymes are steroid-regulated. Furthermore, free fatty acids can be considered as positive or negative common modulators and/or messengers of the steroids and the peptide factors regulating the mitogenic processes.