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[Application of stem cells in orthopedics].

Regeneration of articular cartilage remains a major challenge in orthopaedics. Cell-based therapies (with chondrocyte and MSCs - mesenchymal stem cells) to augment cartilage repair have received considerable interest during recent years. Adipose MSCs have been used in the Czech Republic for osteoarthritis therapy, despite not being re-commended by the Czech Orthopaedic Association. This lecture reviews the studies and their level of evidence for orthopaedic routine therapy of osteoarthritis.Key words: mesenchymal stem cells - osteoarthritis.