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Uncross-matched blood is unnecessary.

The proposition ‘uncross-matched RBCs save lives’ cannot be justified by just showing a few lives are saved in one of the world’s major trauma centres. It must be shown that, when used in an ordinary hospital setting, more lives are saved than lost. What are the risks and what are the benefits of using uncross-matched blood and, on balance, which is the greater? To answer this we need to ask three questions: Is uncross-matched blood necessary, safe and the best use of resources?