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The Macrophage Content of Tumors Is Unrelated to Levels of NK Cell‐Mediated Resistance

Three malignant tumors (3LL carcinoma, mFS6 sarcoma, and B16 F1 melanoma) were transplanted in mice with congenital (beige) or acquired (antiasialo GM1‐treated) defects of natural killer cell (NK) activity. The macrophage content of the neoplastic tissues was not influenced by host NK activity levels. These data suggest that NK cell‐mediated resistance does not play an appreciable role in the regulation of the levels of tumor‐associated macrophages in established malignancy.