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Colorectal Cancer Risk in Patients Affected with Crohn's Disease

TO THE EDITOR: Jess et al. have presented the results of a meta-analysis based on the results of population-based studies evaluating the risk of colorectal (CRC) and small bowel (SB) cancer in patients affected with Crohn's Disease (CD) (1). While the paper is quite interesting and well written, we would like to point out that the authors did not identify all the papers on this issue, even according to their strict criteria. We have recently published such a paper in a major journal (2), reporting the follow-up results of a population-based cohort of ulcerative colitis and CD patients residing in the metropolitan area of Florence, central Italy. This cohort included all patients identified in the area in the period 1978–1992 and the follow-up is still ongoing with a very low proportion of patients lost; we have recently updated our mortality results (3,4).