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Serum proBDNF availability predicts memory gains in the FINGER multimodal lifestyle intervention

Brain‐derived neurotrophic factor (BDNF), including the mature form (mBDNF) and its precursor (proBDNF), has an important role in synaptogenesis, and is possibly also involved in pathophysiological mechanisms related to dementia. In this study we relate, for the first time, serum levels of both mBDNF and proBDNF with cognitive changes in elderly persons at risk of dementia during a multimodal life‐style intervention.