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ANAEROBIC GROWTH REQUIREMENTS OF STAPHYLOCOCCI AND THE ENZYMES OF PYRIMIDINE SYNTHESIS

The nutrition of Staphylococcus aureus was studied in detail almost 40 years ago by Richards0n.l Uracil and pyruvate were shown to be needed for anaerobic growth, whereas they were not required aerobically; later,* acetate was found to replace pyruvate. The development of knowledge of intermediary metabolism and its control has been derived largely from Escherichia coli, which is equally competent in biosynthesis with or without oxygen. That knowledge makes possible an understanding of the biosynthetic failures of S. aureus; this paper considers these problems.