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Revitalizing science in a risk-averse culture: reflections on the syndrome and prescriptions for its cure.

This paper considers problems with the scientific culture and granting systems, the most important of which is an aversion to risk. Grant awards tend to be "safe" rather than bold. This discourages the fresh approaches that may bring important breakthroughs. The paper then suggests remedies that could restore the scientific enterprise to one that is friendlier to fresh thinking.