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Mitogenic effects of oestrogen mediated by a non‐genomic receptor in human colon

Oestrogens are important mitogens in epithelial cancers, particularly where tumours express complementary receptors. While the traditional model of oestrogen action involves gene‐directed (genomic) protein synthesis, it has been established that more rapid, non‐genomic steroid hormone actions exist. This study investigated the hypothesis that oestrogen rapidly alters cell membrane activity, intracellular pH and nuclear kinetics in a mitogenic fashion.