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Endocrine influences on the detrusor of male and female cats

The effects of ATP, adenosine (ADS), β,γ‐methylene ATP (APPCP), norepinephrine (NE), and hypogastric nerve stimulation (HGS) on urinary bladder responsiveness have been studied in male and female cats. Recent studies indicated binding sites for estradiol and testosterone in the urinary tract of animals. Other studies have demonstrated that estrogen alters the effects of certain agonists in urinary tract smooth muscle, although the mechanism of this effect is not known. The present study was designed to determine if differences occurred in the response of bladder smooth muscle in male vs. female cats to various stimuli and if surgical or drug pretreatment alters the response.