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[Analysis of leptin pulses in serum in women with polycystic ovary syndrome].

OBJECTIVES
Authors estimate the influence of body mass on the leptin serum concentrations changes in course of 24 hours in twelve women with polycystic ovary syndrome (PCOS).


MATERIAL AND METHODS
The course of leptin pulses was analysed in two volunteers' six-persons groups, both with PCOS. first group with BMI < 22 kg/m2 and the second group with BMI >26 kg/m2. The blood samples (0,5 ml) were taken from cubital vein in 15-20 minutes intervals through 48 hours. In the first day of clinical experiment three meals were accepted but in the second day the women were starved and they could drink only mineral water.


RESULTS
The significant difference in average leptin concentration in any woman's group between each experimental day was observed. The value of leptin pulses amplitude compared between both women's group on each experimental daytime was significant too. The results we got relating number of leptin pulses and their duration time compared between both women's group and into groups between night and day were not statistically significant.


CONCLUSION
For leptin pulses detection in blood the cluster method was applied, which confirmed the pulses appearance in leptin secretion in both woman's group.