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[Detection of ABH(O) isoantigens in the urinary transitional epithelium by the specific red cell adherence test (SRCA) (author's transl)].

DETECTION OF ABH(O) ISOANTIGENS IN THE URINARY TRANSITIONAL EPITHELIUM BY THE SPECIFIC RED CELL ADHERENCE TEST (SRCA) Tetsuro Kato Department of Urology, Akita University School of Medicine Isoantigens A, B and H(O) identical with those present in erythrocyte are also found in various normal tissues, the majority of which are derived from entodermal origin. Previous investigators suggested that the blood group substances are affected by cancerous transformation. Although immunofluorescence technique has been commonly used for demonstration of the isoantigens, the specific red cell adherence test (SRCA), a modified Coombs' mixed cell agglutination technique, can be employed for the same purpose. Paraffin-embedded tissue sections obtained from 20 cases of urothelial tumors including 18 bladder carcinomas, a ureteral carcinoma and a leukoplakia of the bladder were submitted to SRCA. The isoantigens were clearly detected in the non-neoplastic urothelium in all cases as well as in the leukoplakia. In the neoplastic lesions, however, the isoantigens were found to be totally or partially disappeared, indicating immunological dedifferentiation. It was considered that loss of the isoantigens was closely related to cancerous transformation from pathological, ontogenic and immunochemical aspects. SRCA is a reproducible, sensitive and technically easy immunohistological technique, and expected to furnish fruitful informations on cancer research.