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[The effect of ambulatory care on the course of cystic fibrosis].

We analyzed the long-term follow-up of 97 patients with cystic fibrosis, who had been treated in our outpatient clinic for at least two years. Clinical, laboratory and lung function parameters were evaluated. At the first visit to the clinic, the patients were 0.1 to 25 years old (median: 4.6 years); CF had been diagnosed 2.9 years (median) earlier. Up to the age of 10 years, mean values for weight for height, vital capacity, pO2 and serum IgG were normal; however, during puberty the values declined into the pathological range. From the first to the second year of centralized treatment, the percentage of patients with underweight decreased from 42% to 31%. Abnormal IgG was found in 56% of patients during the first and in 42% of patients during the second year. No deterioration of the mean values was observed during the following five years, reflecting no progression of the disease. Centralized treatment of CF patients influences the course of this disease favourably. To permit the best possible prognosis for each patient, all children with CF should be transferred to a CF clinic soon after diagnosis has been established.