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[Comparative studies of the effect of various gestagens with special reference to the manifestation of rhythmic effects].

Effects of single doses of 7 gestagens were studied in 298 women with menstrual cycle disorders (primary secondary and intermittent amenorrhea pronounced menstrual irregularity). Withdrawal bleeding was observed in 238 women. In addition 67% of these manifested "follow-up" bleeding at intervals averaging 13.31 nor - 2.8 days 1-8 times. The follow-up bleeding was noted in women with each disorder and after each gestagen. Continuous gestagen treatment for 90 days however resulted in a biphasic reaction in 14 of 18 women with secondary amenorrhea; in 5 cases pregnancy occurred. Basal temperature rise or pregnancy occurred in the same rhythm as the follow-up bleeding. The implications of these findings are discussed.