{'fraction_non_alphanumeric': 0.032535297728667895, 'fraction_numerical': 0.01596071209330878, 'mean_word_length': 5.680327868852459, 'pattern_counts': {'":': 0, '<': 1, '<?xml version=': 0, '>': 1, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Postprandial Hyperglycemia‐Induced Vascular Endothelial Dysfunction is Unaffected by a Green Tea Containing Starch Confection

Postprandial hyperglycemia (PPH) induces vascular endothelial dysfunction (VED) by increasing oxidative stress. Green tea lowers cardiovascular disease risk, possibly through its catechins that reduce oxidative stress and/or PPH consistent with a lowering of α‐amylase activity in vitro. We hypothesized that a green tea‐containing starch confection would protect against VED by suppressing PPH‐mediated oxidative stress that lowers nitric oxide bioavailability. In a double‐blind, randomized, cross‐over study, healthy men (n=15) ingested a starch‐based confection (50 g starch) containing 0 or 1 g of decaffeinated green tea extract (GTE) prior to evaluating brachial artery flow‐mediated dilation (FMD), plasma glucose, and markers of nitric oxide (NO) status and lipid peroxidation at 30 min intervals for 3 h. Plasma glucose increased at 30 min and returned to baseline at 90 min, and FMD decreased at 60 min, relative to baseline (P<0.05) in both groups regardless of GTE (P>0.05). Data for both trials were then collapsed to better define PPH‐induced VED in response to the starch confection. Plasma malondialdehyde increased at 30 min and remained elevated for 3 h whereas asymmetric dimethylarginine relative to arginine was increased at 60 min only. Collectively, a starch‐based confection induced VED in association with PPH regardless of GTE incorporation, which occurred consistent with increases in oxidative stress that reduce NO bioavailability. Supported by OSU Food Innovation Center.