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Stretch‐induced Ca2+ independent ATP release in hippocampal astrocytes

Similar to neurons, astrocytes actively participate in synaptic transmission via releasing gliotransmitters. The Ca2+‐dependent release of gliotransmitters includes glutamate and ATP. Following an ‘on‐cell‐like’ mechanical stimulus to a single astrocyte, Ca2+ independent single, large, non‐quantal, ATP release occurs. Astrocytic ATP release is inhibited by either selective antagonist treatment or genetic knockdown of P2X7 receptor channels. Our work suggests that ATP can be released from astrocytes via two independent pathways in hippocampal astrocytes; in addition to the known Ca2+‐dependent vesicular release, larger non‐quantal ATP release depends on P2X7 channels following mechanical stretch.