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Modulation of T-dependent cell-mediated immune responses by antigen-reactive cell opsonization and active suppression.

We have studied both specific and non-specific suppression in allogeneic combinations. On the one hand, achievement of specific suppression may circumvent both HVGR and GVHR, while on the other, Cy-resistant suppressor cells may exacerbate the GVHR in bone marrow graft recipients. A greater understanding of both of these aspects of modulation of immune responsiveness will be important in clinical bone marrow transplantation.