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Effect of X-radiation on salivary gland growth in the rat. IV. Relative effects of local irradiation on growth, regressive and secretory phases of sialadenotrophism.

SummaryAdaptive growth of salivary tissues in the rat (growth phase of sialadenotrophism), induced by treatment with isopropylnoradrenaline (ISOP), was principally due to the hypertrophy of acinar cells assisted by a relatively short and limited phase of acinar-cell hyperplasia (cell division) which caused corresponding increases in total glandular DNA. This hyperplastic component of growth was radiosensitive. Increases in glandular protein and RNA due to cell hypertrophy were radioresistant. Decreases in gland-weight, protein, RNA and DNA, which occurred rapidly after treatment with ISOP had been terminated (regression phase), were due to (a) regression of cell hypertrophy and (b) loss of super-numerary acinar cells that had accumulated during the growth phase. Local irradiation (1500 rads) failed to affect the rates of regression of hypertrophy and cell loss. Secretion and resynthesis of salivary enzyme (amylase) by parotid gland, which had become enlarged in rats treated with ISOP, were similarly radio...