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Proteomics of Protein Trafficking

Organs are interdependent and specialized – they communicate to enable organismal processes including growth, energy metabolism, and reproduction. Secreted peptides and proteins are essential regulators of homeostasis, and they compose a poorly‐characterized communication network. Secreted factors are also relevant for disease: obesity affects 40% of the US population and results from poorly‐characterized dysfunctional systemic signaling. Despite their relevance to homeostasis and disease, many additional factors remain to be identified. Characterizing the factors involved has been challenging, because conventional methods cannot identify low‐abundance proteins or their origins and destinations. The broad goal of my new laboratory at Scripps is to apply novel high‐throughput quantitative approaches we developed to interorgan communication in mammals, in order to understand the identity of the factors involved, which organs they originate from and target, their functions, and regulation of their production in disease.