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Importance of temporal relationships in combined modality radioimmunotherapy of breast carcinoma

The beneficial effects of radioimmunotherapy (RIT) may result from activation of molecular pathways that lead to programmed cell death (apoptosis). The influences of sequence and timing of 90Y‐DOTA‐peptide‐ChL6 antibody (90Y‐ChL6) and anti‐epidermal growth factor receptor antibody (ch225) or paclitaxel (Taxol; Bristol‐Myers Squibb, Princeton, NJ) on efficacy and toxicity were examined.