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What is the cancer risk in Crohn's disease?

P rior studies have established that patients with inflammatory bowel disease (IBD), specifically those with extensive and long-standing ulcerative colitis (UC), have an increased risk of subsequent colorectal cancer. These studies of UC, however, have been based on data from tertiary care settings, primarily in the United States and the United Kingdom. Others, even from similar geographic areas in the US, have shown that the magnitude of this risk may not be so significant.1,2 In addition, others have argued that the risk of cancer is not increased in patients with colitis and data may be further influenced by an underlying baseline risk of colon cancer that is geographically or environmentally influenced, rather than related to IBD per se.3