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Combining risk-reducing salpingo-oophorectomy with mastectomy and reconstructive surgery in BRCA1 and BRCA2 mutation carrier

1532 Background: Women who test positive for a germline BRCA1/2 mutation are offered cancer surveillance or risk reducing surgery. Coordinating risk reducing gynecologic surgery with breast and reconstructive surgery is a strategy to consider. Methods: Review of the Cancer Risk Program registry identified 43 BRCA1/2 mutation carriers undergoing concurrent or sequential surgery for RRSO and bilateral mastectomy by the Gynecologic Oncology, Breast Oncology, and Plastic Surgery services. This study evaluates the surgical outcomes of combining risk reducing gynecologic surgery with breast and reconstructive surgery. Student's t-test and chi-square comparisons were used. Results: Between August 1998 to July 2007, 21 women underwent a concurrent procedure of RRSO and bilateral mastectomy, while 14 had RRSO preceded by mastectomy, and 8 had oophorectomy followed by mastectomy. The mean age of all women was 44.9 (range 33–75). In comparison to those undergoing a concurrent procedure, women who had a subsequent se...