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Cardiovascular Pathology: Poster#067 IS ISOLATED AORTITIS MILD FORM OF TAKAYASU AORTITIS? COMPARISON OF CLINICAL AND HISTOPATHOLOGICAL FEATURES

Background: Takaytasu aortitis (TA) is an inflammatory large-vessel vasculitis of unknown origin. In rare cases, isolated aortitis (IA) is usually diagnosed by its incidental microscopic findings after ascending aortic surgery. Some of isolated aortitis are thought to be IgG-4 related disease. Methods: We compared 52 TA patients and 7 IA patients who underwent aortic surgery to investigate clinical and histopathological features. Results: Patients with TA were older than IA patients (M/F; 3/4) (median 56 vs 78 years; p < 0.003). In 52 patients with TA, 23 were already diagnosed in younger age (median 32 years), 21 received immunosuppressive therapy, and 8 received aortic valve replacement because of severe aortic regurgitation. All 7 patients with IA were not diagnosed until microscopic examination revealed it after surgery. Microscopic findings of atherosclerosis and calcification were comparable both two groups. IgG-4 positive plasma cell proliferation was not found in TA and IA. In-hospital mortality was 4% vs 0%, and re-admission for any vascular problems was 45% vs 16%. Conclusions: In comparison to IA, TA tends to show poor clinical outcome because of its multiple vascular damage. Clinically, isolated aortitis may be a distinct disease of TA. IA was also considered in case of ascending aortic aneurysm.