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Numerical study of IP3-dependent Ca2+ spiral waves in Xenopus oocytes

Based on a spatial extended Tang-Othmer Ca2+ model, intracellular Ca2+ spiral waves in Xenopus oocytes are numerically studied. Results show that the spiral dynamics depends on the concentration of the messenger molecule inositol 1,4,5-trisphosphate(IP3). Varying the IP3 concentration, the spiral dynamics undergoes transitions from rigidly rotating spiral waves to meandering ones, even the spiral waves cannot exist in the system for large or little enough IP3 concentration. Understanding the dependence of spiral dynamics on IP3 concentration provides us theoretical clue to control the spiral waves through changing the IP3 concentration in experiments.