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EFFECT OF GESTATIONAL AND POSTNATAL AGE ON GLOMERULAR FILTRATION RATE (GFR) ANO TUBULAR MAXIMA OF GLUCOSE TmG IN HUMAN INFANTS

Twenty-four healthy newborn infants with gestational ages ranging from 26 to 42 weeks were studied at 2 days to 9 weeks postnatal age to evaluate the rate of glomerular and tubular maturation. Glomerular function (GFR) was assessed by inulin clearance and tubular function by TmG. Birth weights of the study infants were appropriate for gestational age. The GFR of fifteen 2-3 day old infants ranges from 17 to 101 ml/min/ 1.73 m2 and is directly related to gestational age (r=0.829). The TmG of fifteen 2-3 day infants ranges from 14 to 149 mg/ min/1.73 m2 and is also directly proportional to gestational age (r=0.710). Serial studies showed extrautertne renal maturation occuring at the same rate as intrauterine. The TmG/GFR ratio did not change significantly with postnatal age (mean=l.29 ± 0.08 S.E.M. in the first 2-3 days and 1.27±0.17 S.E.M. after 3 days). These data show that the development of glomerular and tubular function in utero is consistent with morphologic maturation, and that following birth, maturational renal changes proceed in a balanced, appropriate direction.