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Anticytokinin Activity of N-Phenyl-and N-Pyridylcarbamates

A new class of non-adenylate anticytokinins, alkyl and phenyl N-phenylcarbamates and related phenyl N-pyridylcarbamates, has been developed. They have a structure that has an immediate resemblance to the non-adenylate class of cytokinins, N ,N′-diphenylureas, and N-pyridyl-N′-phenylureas, and the design of the molecule was made based on insight into the bioisoteric nature between the previous, non-adenylate s-triazine anticytokinins and the carbamate and urea structures. The activity in terms of the I50 value of the most potent members, 4-fluoro- and 4-chlorophenyl N-(2-chloro-4-pyridyl)carbamates, was 0.3 - 0.5 x 10-6 M when examined by the tobacco (Nicotiana tabacum L.) callus assay in the presence of 0.05 x 10-6 M kinetin.