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Characterization and Application of a New Monoclonal Antibody with High Specificity for Helicobacter hepaticus

Background and Aims:  Infection with Helicobacter hepaticus is suggested to play a role in the pathogenesis of chronic liver disease in humans. However, reactive antigens among Helicobacter species make the development of an H. hepaticus ELISA test with high specificity difficult. A new monoclonal antibody from a hybridoma clone (HRII‐51) showed high specificity to H. hepaticus without cross‐reaction to other gastrointestinal bacteria.