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Failure of single-dose lecithin to alter aspects of central cholinergic activity in Alzheimer's disease.

The effect of a single dose (15 g/70 kg) of lecithin (95% phosphatidylcholine) on several measures of central cholinergic activity (memory, cortisol, prolactin, pulse, blood pressure) was assessed in individuals with Alzheimer's disease. In contrast to the reported effects of physostigmine, a cholinesterase inhibitor, lecithin had no effect on these parameters, despite significant increases in plasma and erythrocyte choline.