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Applications of Nanomaterials in Combined Antitumor Therapy

Cancer has historically been a significant problem in the world. Traditional clinical strategies for treating tumors including chemotherapy, radiation therapy, surgery. Currently, some novel anti-cancer therapeutics such as immunotherapy, photodynamic therapy (PDT), photothermal therapy (PTT) also exert a broad prospect. However, though they may inhibit tumors to some extent, due to the poor targeting ability, some of them show side effects and huge individual differences, so limited curative effect still causes the high mortality. Therefore, it was necessary to find some methods to overcome the treatment defects. In recent years, multi-mode combined anti-tumor therapy has shown potential to improve the therapeutic efficacy. But how to deliver drugs of different characteristics to desire sites efficiently and synchronously is an urgent problem. In this review, we discuss the applications of nanotechnology in some new combined anti-tumor therapies, including several new combined therapeutics, the advances of nanocarriers used in multimode combined antitumor therapeutics, and some prevalent nano-materials in combined strategies. Finally, we outline some future trends and limitations of nano-delivery of combined treatments.