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AB1052 ASSOCIATION BETWEEN BODY MASS INDEX AND HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH GOUT

Gout is an inflammatory disease that may cause decreased function and health-related quality of life (HRQoL) [1]. In a few studies, it was demonstrated a negative relationship between body mass index (BMI) and HRQoL in individuals with gout; in the others, it was not confirmed.This study aimed to assess the BMI and quality of life in patients with gout and to value the association between these variables.All 151 patients were male with mean age (M±SD) 52.4±9.2 years. Diagnosis of gout was based on the ACR/EULAR 2015 criteria [2]. Tophi was present in 51 (33.7%), and the median duration of gout was 7 years (25th to 75th interquartile range (IQR), 4 to 14.0). The mean uric acid in serum was (sUA) (M±SD) 477.2 ±120.5 µmol/l. HRQoL was evaluated by the SF-36 and calculated summary physical (PCS) and mental component (MCS) scores of the SF-36.About 67.5% of the surveyed patients had BMI > 30 kg/m2, while the average index was 31.9±3.4. The overall median SF-36 PCS score was 33.9 (IQR 28.8 to 38.4), and the overall median SF-36 MCS score was 41.1 (IQR 34.2 to 47.4). Among the eight subscales of SF-36, there was a correlation between BMI and role physical functioning (RP) r = -0.22 (p<0.01), general health (GH) r = -0.17 (p<0.05), but others were statistically not significant (P>0.05). Our analysis showed negative associations between BMI and physical and mental HRQoL. BMI correlated with PCS r = -0.19 (p<0.05) and MCS r = -0.17(p<0.05).This analysis provides further evidence to support the injurious effects of obesity on different aspects of health patients with gout and underline the importance of weight loss.[1]Chandratre, P., Mallen, C., Richardson, J., Muller, S., Hider, S., Rome, K., & Roddy, E. (2018, August). Health-related quality of life in gout in primary care: Baseline findings from a cohort study. In Seminars in arthritis and rheumatism (Vol. 48, No. 1, pp. 61-69). WB Saunders.[2]Neogi, T., Jansen, T. L. T. A., Dalbeth, N., Fransen, J., Schumacher, H. R., Berendsen, D., & Taylor, W. J. (2015). 2015 gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis & rheumatology, 67(10), 2557-2568.None declared