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Chemical protection of the mouse against radiation-induced life shortening.

The effectiveness of four radioprotective compounds in reducing life shortening from radiation exposure was evaluated for each sex in two inbred strains of mice. Major differences in effectiveness were found which were highly dependent on sex, strain, and radiation dose level. It was concluded that the effectiveness of these agents is determined by whether they protect against the particular radiation-induced lesions that lead to early death. The nature of these lesions apparently varies by sex and strain and possibly radiation dosage.