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VITAMIN E AND ITS EFFECTIVENESS IN MANAGEMENT OF GRADE II & III HAEMORRHOIDS

Objective: The aim of the study is to evaluate the effectiveness of vitamin E due to its potent antioxidant with anti-inflammatory properties by assessing Vitamin E levels and Visual analogue scale. Methods: This prospective randomized study was carried out for a period of 4 months in private hospital, Chennai. A total of 30 patients were enrolled based on the inclusion and exclusion criteria and were randomized into 2 groups Group A (standard treatment) and Group B (standard treatment plus vitamin E oral supplement).The effectiveness was observed by assessing vitamin E levels and VAS score at baseline, 1st, 3rd and 5th week after the start of oral vitamin E supplementation. Results: In total, 30 patients were randomized into Group A and Group B with 15 patients each. Among 30 patients 18 patients were males and 12 patients were females. In that 7 patients in age group 18-25 years, 13 patients in age group 26-35 years, 8 patients in age group 36-45 years and 2 patients were above 45 years of age At baseline, the average range of intensity of pain was 6, at 1st week the VAS score was 6 in Group A and 4 in Group B, at 3rd week 5 in Group A and 3 in Group B and at 5th week 4 in Group A and 1 in Group B. Based on Vitamin E levels, the average level at base line was 5 in Group A and 4.1 in Group B, followed by 5 in Group A and 4.5 in Group B at 1st week, 4.8 in Group A and 5.6 in Group B at 3rd week, and 4.7 in Group A and 7 in Group B at 5th week. Conclusion: Our study concluded that the vitamin E levels increased and the intensity of pain has reduced after receiving vitamin E oral supplementation along with standard treatment which was a good sign for its effectiveness in haemorrhoids Keywords: Haemorrhoids, Vitamin E, alpha-tocopherol, oxidative stress, antioxidant