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Factors affecting the outcome of excimer laser photorefractive keratectomy: a preliminary multivariable regression analysis

Multivariable regression analysis was used to evaluate the combined effects of some preoperative and operative variables on the change of refraction following excimer laser photorefractive keratectomy for myopia (PRK). This analysis was performed on 152 eyes (at 6 months postoperatively) and 156 eyes (at 12 months postoperatively). The following variables were considered: intended refractive correction, patient age, treatment zone, central corneal thickness, average corneal curvature, and intraocular pressure. At 6 months after surgery, the cumulative R2 was 0.43 with 0.38 attributed to the intended correction and 0.06 attributed to the preoperative corneal curvature. At 12 months, the cumulative R2 was 0.37 where 0.33 was attributed to the intended correction, 0.02 to the preoperative corneal curvature, and 0.01 to both preoperative corneal thickness and to the patient age. Further model augmentation is necessary to account for the remaining variability and the behavior of the residuals.