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[Gene expression changes of cartilage matrix of condylar cartilage with anterior disc displacement].

OBJECTIVE
To study the gene expression changes in extracellular matrix of condylar cartilage following disc anterior displacement of rabbit TMJ.


METHODS
The right sides of 28 joints in 40 rabbits were subjected to surgical operation of disc displacement. The condylar Collagen II and Aggrecan mRNA expression were detected by in situ hybridization.


RESULTS
Collagen II and Aggrecan mRNA mainly expressed in the lower zone of condylar chondrocyte. Aggrecan mRNA decreased faster than collagen II following disc displacement, and adjusted to normal later.


CONCLUSION
Anterior disc displacement leads to alteration of extracellurar matrix gene expression in the condylar chondrocyte, which means the start of remodeling.