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Adaptation of exercise‐induced stress in well‐trained healthy young men

What is the central question of this study? Exercise is known to induce stress‐related physiological responses, such as changes in intestinal barrier function. Our aim was to determine the test–retest repeatability of these responses in well‐trained individuals. What is the main finding and its importance? Responses to strenuous exercise, as indicated by stress‐related markers such as intestinal integrity markers and myokines, showed high test–retest variation. Even in well‐trained young men an adapted response is seen after a single repetition after 1 week. This finding has implications for the design of studies aimed at evaluating physiological responses to exercise.