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Pre-clinical evaluation and optimization of image quality for a next generation tomosynthesis prototype

A next generation tomosynthesis (NGT) prototype has been developed to investigate alternative scanning geometries for digital breast tomosynthesis (DBT). Performance of NGT acquisition geometries is evaluated to validate previous phantom experiments. Two custom NGT acquisition geometries were compared to a conventional DBT geometry. Noise power spectra are used to describe features of specimen image reconstructions and compare acquisition geometries. NGT acquisition geometries improve high-frequency performance with superior isotropic super resolution, reduced out-of-plane blurring, and better overall reconstruction quality. NGT combines benefits of narrow- and wide-angle tomosynthesis in a single scan improving high-frequency spatial resolution and out-of-plane blurring, respectively.