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Motion compensation for detecting glucose through dual wavelength polarimetric system

The increasing prevalence of diabetes in the United States has led many to pursue methods for non-invasive glucose detection using various optical approaches such as NIR absorption spectroscopy, Raman spectroscopy, fluorescence spectroscopy, and polarization. Polarization approaches using the aqueous humor as the sensing site have been previously shown to achieve 5 mg/dl accuracy in vitro, however accuracy in vivo has yet to be obtained due to motion induced birefringence changes in the cornea. A dual-wavelength close-looped system was developed to compensate for motion artifact. This method has shown 15 mg/dl accuracy in the presence of birefringence changes in the optical path in vitro similar to those that occur in the cornea -- something previous systems were not capable of doing.