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Digoxin Therapy: A Clinical Pharmacokinetic Approach

Within certain limitations, digoxin can be prescribed for individual patients on a sound scientific basis. The use of pharmacokinetic principles and digoxin radioimmunoassay can improve the overall quality of treatment with this drug and reduce the incidence of adverse reactions. Variations in bioavailability and intestinal absorption are important factors in the determination of dosage and should be reduced to a minimum by improved pharmaceutical formulations.