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Nesidioblastosis is Not a Histopathologic Diagnosis. 380

Nesidioblastosis is a condition characterized clinically by intractable hyperinsulinemic hypoglycemia. Since serum insulin levels are rarely extremely elevated, diagnostic confirmation has historically relied upon characteristic histopathologic changes in the pancreatic tissue removed as a therapeutic modality of this condition. Although the finding of abundant nests of endocrine tissue budding off of ductal elements is considered to be confirmatory, there have been reports in the adult and pathology literature that such findings may be present in normal individuals. We present here the case of an infant which demonstrates that nesidioblastosis is not a histopathologic diagnosis.