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Calcitonin gene‐related peptide‐induced hemodynamic changes in migraine with and without aura

Exogenous calcitonin gene‐related peptide (eCGRP) can induce CGRP‐induced headaches (CGRP‐IH) and aura in migraine with aura (MA). This implies a common pathophysiological mechanism of trigeminovascular sensitization (TVS) in migraine headaches and aura. The aim was to assess hemodynamic changes in cerebral circulation induced by eCGRP. We predicted that cerebral hemodynamic changes may differ between migraine without aura (MO) and MA.