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Patch testing with parabens

A multicenter study of skin sensitization to methylchloro-isothiazolinonejmethylisothiazolinone (MCI/ MI) was conducted by the North American Contact Dermatitis Group (NACDG) from August 1988 to September 1989. 949 patch test clinic patients were patch tested with 100 ppm MCI/MI. 18 had positive reactions (1.9%). Further patch testing was done with dilutions of MCI/MI. Of 10 subjects who initially had positive patch tests, 8 (80%) were positive again with 100 ppm, 3 (30%) with 50 ppm and 2 (20%) with 25 ppm MCI/MI. Double-blind USE tests showed that 5 (50%) who had positive patch tests to 100 ppm MCI/MI reacted to a generic skin care lotion preserved with 15 ppm MCI/MI. Our results when compared to previous NACDG data on MCI/MI do not suggest an epidemic of MCI/MI skin sensitivity in the United States. When compared to other standard allergens, MCI/MI did not enjoy a great rate of positive patch test reactions during the study period.