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Genetic Background Determines Anthocyanin Effects on Glutathione Redox Balance

Anthocyanins are secondary plant metabolites that provide the blue, red, and purple color of many plants. In recent years, these compounds have generated considerable interest among biomedical researchers due to their reported health benefits. It has been proposed that commonly consumed anthocyanins, such as cyandin‐3‐O‐β‐glucoside (C3G), confer cellular protection by increasing biosynthesis of glutathione (GSH), an endogenous antioxidant. However, it is unclear whether anthocyanin‐induced health effects are subject to genetic control. In this project, we tested the hypothesis that genetic background regulates anthocyanin‐induced alterations in GSH levels and redox balance (GSH/GSSG).