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Steroid metabolism by fetal and neonatal rat reproductive tracts.

Steroid metabolism by fetal and neonatal rat reproductive tracts was investigated. Genital ducts of 16.5- and 20.5-day-old male fetuses and of male newborns reduced progesterone to 5alpha-pregnane-320-dione and 3alpha-hydroxy-5 alpha-pregnan-20-one and newborn ducts converted pregne nolone to pregnanedione. Both male and female newborn (16.5 day) genita l ducts metabolized dehydroepiandrosterone sulfate to free alcohol and 5-androstene-3beta17beta-diol. Control tissues (liver lung kidney) revealed similar steroid reductase and sulfatase activity as ductal tissue. Carbon-21 to carbon-19 steroid conversion was not seen. These results demonstrate the capacity of perinatal rat genital tracts for reductive progesterone metabolism for steroid sulfatase activity and confirm the capacity for reduction of the 17-keto group of dehydroepiand rosterone.