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Early histochemical changes induced by manganese chloride in the renal tissue of rabbit.

In rabbits intravenous injection of manganese chloride (3.5 mg/kg) over a period of G weeks induced histoenzymic and histological alterations in the renal tissue. There were patchy areas showing loss in activity of succinic dehydrogenase after 4 days of injection. The activity of ATPase and glucose-6-phosphatase was inhibited in focal areas of the renal cortex after 8 days while reduction in activity of alkaline phosphatase and monoamine oxidase occured at day 30. The acid phosphatase activity was increased in the cortex by 30 days. Histologically the earliest changes in the form of irregular areas of degeneration of the proximal convoluted tubules were noted on day 16. These laterations suggest that manganese chloride inhibits succinic dehydrogenase activity, leading to the alteration of other enzyme systems and eventual cell destruction.