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Urinary excretion of LH-RH-like material from birth to puberty

Endogenous LH-RH-like material was radioimmunoassayed in human urine, after extraction by silicate and methanol. This material was shown to be related to LH-RH by its immunological, physicochemical and to a lesser extent, biological properties : using 3 antisera with different affinities for LH-RH C- and N- terminals, the extracted material appeared heterogeneous and contained slight decapeptide-like immunoreactivity. This decapeptide-like material showed on sephadex a chromatographic similarity to rat hypothalamic extracts and to the unextracted material excreted in urine after intravenous injection of synthetic LH-RH. Whilst adult values of urinary decapeptide-like material ranged from 4 to 30 ng/day, the excretion was lowest in infants up to the age of 3 months (<1, 5 ng/day). From 1 to 6 years, the observed values were less than 4 ng/day. From the age of 7, some higher values were found, suggesting a possible role of LH-RH in the initiation of puberty.