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The effect of the electrode resistance on the performance of code-multiplexed resistive pulse sensing

Microfluidic Coded Orthogonal Detection by Electrical Sensing (Microfluidic CODES) is a technology that can be used to code-multiplex a large number of electrical sensors on a microfluidic device, so that the spatiotemporal information from suspended particles on the device can be obtained from a single electrical waveform. In this paper, we focus on the scaling of the Microfluidic CODES technology. We specifically investigate the effect of surface electrode resistance on the device performance using an equivalent circuit model and experiments with cell suspensions. Based on our analysis, we design and demonstrate an optimized device with improved performance. Taken together, our results show that electrode resistance is an important design parameter for large scale sensor network design in Microfluidic CODES.