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POSTER DISCUSSION‐ASTHMA, DIAGNOSIS OF ALLERGIC DISEASES

Airway inflammation is a very important feature of asthma and occurs simultaneously with increased hyperreactivity. We have examined whether the local inflammation provoced by allergen challenge of patients with atopic asthma is associated with the apperance, in vivo, of interleukin-8 (IL-8). Bronchoscopy and BAL for further IL-8 investigations were performed before and after challenge test with histamine (n= 11, aged 27*2.6), grass pollen antigen (n=8, aged 28.9*3), and PBS (n=5, aged 25.3rt3). ELISA test (kits from R&D, USA) was used to measure IL-8 concentration in l ml of lavage fluid recovered. There was observed increased level of IL-8 after challenge test with histamine (mean*SEM): from 97i39.2 to 383.7459.6 pg/ml ( ~ 4 . 0 5 ) and after challenge test with grass pollen antigen: from 241r170 to 1095k657.8 p g / d (p.<0.05). The increased concentration of IL-8 correlated with neutrophils in BAL (Kendall's correlation coefficient +0.5, and +0.7 respectively). We suggest that IL-8 may participates in bronchial hyperresponsiveness in asthma patients. This study confirms chemotactic activity of IL-8 for neutrophils.