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EFFECT OF POSTOPERATIVE ADMINISTRATION OF HYALURONIC ACID/TREHALOSE DROP ON CORNEAL HEALING AFTER PHACOEMULSIFICATION SURGERY

: This study aimed to evaluate the efficacy of hyaluronic acid/trehalose drop for corneal epithelial and stromal healing after phacoemulsification surgery. It is a retrospective randomized comparative study. The patients had phacoemulsification surgery divided into two groups. These patients received either a mixture of sodium hyaluronate and Trehalose (Group 1) or sodium hyaluronate 0.15% (Group 2) postoperatively. The effect on corneal epithelial and stromal healing was evaluated using Oxford staining and the vertical scar length measured by optical coherence tomography. Preoperative and post-operative findings for Oxford staining, Schirmer’s test, tear film break-uptime, and ocular surface disease index scores were also evaluated. The correlation between scar length and tear film parameters was examined. The effect of Trehalose on the epithelial healing and stromal scar formation was assessed. Group 1 and 2 each had 30 eyes. The two groups were similar according to age and sex distribution. In terms of epithelial healing, it was faster in the trehalose group, although there was no statistical difference between the two groups. The length of the stromal scar was not significantly different between groups. However, a smaller scar formation was observed in group 1 compared to those in group 2 at both one week and one month postoperatively. There was also no significant difference between the groups in tear film parameters. The stromal scar length was correlated with the Schirmer test on the 15th day. Although it was not statistically significant, the hyaluronic acid/trehalose may affect epithelial healing and stromal scar formation positively after phacoemulsification surgery. Larger and longer studies are needed. to investigate Trehalose’s effect on the healing process, changes, and scar formation in epithelium and stroma following phacoemulsification surgery. Secondly, the difference in tear film parameters by post-operative administration of Trehalose was evaluated.