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Sample Pooling for Microarray Analysis : A Statistical Assessment of Risks and Biases

Pooling of RNA samples isolated from tissue is a strategy that can be implemented in microarray experiments when the amount of sample RNA is limiting, or when variation across samples must be reduced. However, it is widely documented that important gene expression information is lost during pooling. This Technical Note qualifies and quantifies the effects of pooling on biological conclusions derived from gene expression data.