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Comment on “Extreme electric fields power catalysis in the active site of ketosteroid isomerase”

Fried et al. (Reports, 19 December 2014, p. 1510) demonstrate electric field–dependent acceleration of biological catalysis using ketosteroid isomerase as a prototypic example. These findings were not extended to aqueous solution because water by itself has field fluctuations that are too large and fast to provide a catalytic effect. Given physiological context, when water electrostatic interactions are considered, electric fields play a less important role in the catalysis.