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ROLE OF BIOMARKERS IN EARLY DETECTION OF PREECLAMPSIA

More than 100 scientific articles have been selected to compose this review. It reflects modern views on various mechanisms that cause the development of preeclampsia with early and late onset. This review provides an analysis of the most promising markers for the early diagnosis of preeclampsia: 22 potential biochemical and 2 biophysical markers in the first and second trimester of pregnancy. The aim was to determine their relevance in the diagnosis of preeclampsia. It has been shown that the level of some markers in the blood was significantly increased or decreased in patients who subsequently developed preeclampsia compared to a control group of patients who had a normal pregnancy. But despite the large number of different markers, their autonomous use does not provide an adequate predictive picture. Subsequent research studies should focus on finding the marker combinations that can then be applied as powerful screening tools for a higher probability of diagnosing PE.