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Association Between the Number of Comorbidities and the Risk of a Serious Infection in Rheumatoid Arthritis Treated by a First Biologic Agent

I n rheumatoid arthritis (RA), some comorbidities have prognostic consequences and increase the risk of infection such as age older than 50 years, a history of infection, diabetes or pulmonary disease, and treatments, notably glucocorticoids. Widdifield et al. found that rural residence, higher comorbidity with chronic lung disease or renal disease, markers of disease severity, and previous infection were associated with serious infections (SIs) in seniors with RA. Thus, it is essential to search for comorbidities in patients treated with immunosuppressant drugs because there is a 2-fold risk of infection compared with the general population. However, beyond the nature of comorbidities, we do not know the impact of the number of comorbidities on the incidence of SI.