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Exosomes Are Comparable to Source Adipose Stem Cells in Fat Graft Retention with Up-Regulating Early Inflammation and Angiogenesis.

503e Moreover, we would like to particularly acknowledge the correctness of the historical reconstruction proposed by the authors, which accurately recognizes that despite the tremendous contributions of Brazil and the Brazilian legends of plastic surgery, gluteal augmentation was not first described by Brazilian authors.5 Indeed, our previous comprehensive analysis of the entire body of the PubMed/MEDLINE literature demonstrated that the first description of gluteal augmentation was produced in the United States and published in the Journal by Bartels et al., who reported the use of a Cronin prosthesis to correct an asymmetry.2,5,6 Cocke and Ricketson were instead the two U.S. authors who first performed an implant-based bilateral gluteal augmentation for purely cosmetic indications.2,5,7 Finally, if we limit our analysis to the area of fat grafting gluteal augmentation, the first article on this topic was published by the Mexican group of CárdenasCamarena and colleagues in 1999. ​ With their retrospective review of 66 patients, they presented a gluteoplasty technique combining liposuction of lumbosacral, subgluteal, and trochanteric areas and lipoinjection of the medial third of the buttocks.2,8 At a mean follow-up of 17 months, they observed a 95.5 percent rate of patient satisfaction, whereas the complications of this initial report were seroma (n = 4), visible irregularities (n = 6), palpable irregularities (n = 2), hyperemia and erythema (n = 12), and, very importantly, fat embolism (n = 1).8 Notably, all these pioneering studies were published in Plastic and Reconstructive Surgery, confirming the consistency of the leading role played by the Journal during its over 70 years of glorious existence.5 DOI: 10.1097/PRS.0000000000007200