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All Things in Moderation: Prevention of Intestinal Adenomas by DNA Hypomethylation

DNA hypomethylation can prevent intestinal tumorigenesis, presumably by reducing epigenetic silencing of tumor-suppressor genes. A study in this issue by Sheaffer and colleagues challenges this notion by showing that severe DNA hypomethylation by tissue-specific Dnmt1 knockout can actually promote intestinal adenoma formation. Cancer Prev Res; 9(7); 509–11. ©2016 AACR. See related article by Sheaffer, et al., p. 534