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Author ' s response to reviews Title : A frequency shift in the anterior default mode network and the salience network in chronic pain disorder

2. The conclusion is misleading. It is not clear why the present results suggest that chronic pain is a “self-sustaining and putatively endogenous mental process decoupled from nociceptive input”. Also, the association between higher frequencies and chronic pain might not be causal. We changed “suggest” to “indicate”. Causality in fMRI studies is a major problem in the field, and in the end, researchers can only show correlations between human behavior and BOLD signals. Nevertheless, the cited literature and the comparison of matched, nonchronic pain-suffering controls indicate that there is at least some reason to consider that the association between higher network frequencies and chronic pain is more than a random association. 3. Last paragraph: It is not clear from the introduction why the authors hypothesize that patients would exhibit an altered high frequency pattern. Malinen et al. [1] showed that chronic pain influences the temporal aspect of functional connectivity by changing the frequency of the spontaneous firing of neurons within the FIN from lower levels (below 0.12 Hz) to a higher range, between 0.12 and 0.24 Hz. As Malinen et al. [1] examined chronic pain but did not distinguish between nociceptive and non-nociceptive pain, there is good reason to speculate that non-nociceptive pain would also increase the frequency of spontaneous firing of neurons within resting state networks. This is now more clearly indicated in the introduction. Methods 4. The procedure used to identify the pain-related networks has to be described with enough detail for other research groups to be able to replicate it. Now, some references are given to other papers that have described the same networks, but exactly how did the authors know that their networks overlapped with the previously described ones? We thank Reviewer 1 for this important critique. Originally, the networks in our study were identified only by visual inspection. Although this approach was widely used in previous