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Effects of caffeine on neuromuscular function in a non‐fatigued state and during fatiguing exercise

What is the central question of the study? What are the effects of caffeine on neuromuscular function in a non‐fatigued state and during fatiguing exercise? What is the main finding and its importance? In a non‐fatigued state, caffeine decreased the duration of the silent period evoked by transcranial magnetic stimulation. Caffeine‐induced reduction of inhibitory mechanisms in the central nervous system before exercise was associated with an increased performance. Individuals who benefit from caffeine ingestion may experience lower perception of effort during exercise and an accelerated recovery of M‐wave amplitude postfatigue. This study elucidates the mechanisms of action of caffeine and demonstrates that inter‐individual variability of its effects on neuromuscular function is a fruitful area for further work.