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Congenital rubella syndrome in Malaysia.

SUMMARY Of the five diseases generally recognised as causing congenital defects, viz., toxoplasmosis, rubella, cy to m egaloviral infection, herpes simplex and syphilis (TORCHES) studied in Malaysia, rubella was found to be the most important. A total of 574 children with features of congenital rubella syndrome (CRS) were examined for rubella-specific 19M (in infants four months and below), and for rubella HAl antibodies (in children six months to four-years-old), and compared with 374 normal Children of the same age groups. Whereas the prevalence rate of rubella in normal children was only 1.3%, in children with CRS (multiple defects) it was 87.3%; with congenital heart disease 71.0%; with congenital cataract 64.0%; with deafness 60.1%; with rash 30.8%; with hepatomegaly 17.1%; with mental retardation 4.1 %. Congenital rubella was not important as a cause of neonatal jaundice (0.9%) anli CNS defects (0%).