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129 ASSOCIATION OF SOCS3 GENE POLYMORPHISMS WITH OVERWEIGHT AND OBESITY IN UYGUR POPULATION IN XINJIANG OF CHINA

Objective: To explore the relationship between suppressor of cytokine signaling 3 (SOCS3) genetic polymorphisms and overweight and obesity in Uygur Chinese general population in Xinjiang. Methods: 1407 Uygur individuals were enrolled (530 males, 876 females), The 3 single nucleotide polymorphisms (rs4949169, rs9914220, rs12953258) in SOCS3 gene were selected, Measure the height, weight, waist and hip circumference, calculate body mass index (BMI). Results: (1) Significant association was found between rs4949168 and the overweight, obesity in males, BMI(GG:AG:AA:(26.44±4.16) kg/m2vs.(27.23±4.34) kg/m2 vs.(27.78±4.48) kg/m2, P=0.042). Rs9914220 was associated with overweight and obesity in Uygur females in Xinjiang HETIAN area. But rs12953258 was not associated with overweight and obesity in Xinjiang HETIAN area. Conclusion: SOCS3 gene was significant associated with overweight and obesity in Uygur population in Xinjiang HETIAN area, and SOCS3 gene associated with overweight and obesity express distinctive in different gender.