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The Comorbidity of Fibromyalgia Syndrome and Attention Deficit and Hyperactivity Disorder from a Pathogenic Perspective

Fibromyalgia (FM) is a central pain sensitivity syndrome manifesting as widespread chronic pain and tenderness with no evidence of soft tissue inflammation. Central sensitization corresponds to heightened and long-lasting sensitivity to peripheral, sometimes subthreshold, noxious stimuli due to long-term potentiation of synapses and altered activity of monoaminergic neurotransmission systems within central pain pathways [1]. Clinical manifestations include widespread chronic pain, muscle tenderness, joint stiffness, fatigue, sleep disturbance, mood disturbance, and cognitive symptoms [1].