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Articles of Significant Interest Selected from This Issue by the Editors

Identification of cellular proteins that contribute to viral entry into target cells is an important step toward a thorough understanding of the entry process. Hochdorfer et al. (p. 6430 – 6442) applied a targeted RNA interference strategy to identify host factors that mediate human cytomegalovirus (HCMV) entry. The tetraspanin CD151 was found to promote viral penetration into endothelial cells and fibroblasts, cell types regarded to differ in the HCMV entry mechanism. This study identifies a cellular protein that is commonly used in HCMV entry into different cell types, which provides a basis for further mechanistic investigations.