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Advances in ultrasound technology.

The International Registry of the Onset of Fetal Anomalies (IRONFAN) was inaugurated in 1991 through the efforts of scientists with personal experience in this field, and the registry was officially founded in 1993 at the third International Society for Ultrasound in Obstetrics and Gynecology (ISUOG) meeting in Las Vegas. IRONFAN was designed to acquire precise knowledge of the natural history of fetal anomalies and convert the ambiguous "somewhere" for identification of abnormalities to specific weeks of gestation. Forty-two centers participated in the creation of a network with a database on the natural history of over 200 different anomalies. In this special issue, several distinguished scientists from this network present papers on selected topics that make up only the tip of the iceberg that IRONFAN represents. They did a fine job. This special issue was made possible thanks to the good advice and encouragement from Dr. George Leopold.