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Uncertainty analysis of thermal damage to living biological tissues by laser irradiation based on a generalized duel-phase lag model

ABSTRACT The effects of uncertainties of laser exposure time, phase lag times, blood perfusion coefficient, scattering coefficient, and diffuse reflectance of light on the thermal damage of living biological tissue by laser irradiation are investigated using a sample-based stochastic model. The variabilities of input and output parameters are quantified using the coefficient of variance (COV) and interquartile range (IQR), respectively. The IQR analysis concluded that phase lag times for temperature gradient and heat flux, laser exposure time, and blood perfusion rate have more significant influences on the maximum temperature and maximum thermal damage of the living biological tissue induced by laser irradiation than the diffuse reflectance of light and scattering coefficient.