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Sodium bicarbonate cotransporter NBCe1 affects the growth and motility of prostate cancer cell lines LNCaP and PC3

Prostate cancer is the most common cancer in men. Prostate cancer develops mainly in older men: 6 cases in 10 are diagnosed in men aged 65 or older while it is rare before age 40, according to the report by the American Cancer Society. The average age at the time of diagnosis is ~66. Similar to other cancers, prostate cancer is developed from genetic and epigenetic changes in normal cells, and environmental and systemic stresses also make significant contributions to cancer aggravation. One of such stresses is acidic tumor microenvironments, which is caused by excessive glycolytic cancer cell metabolism, hypoxia, and inefficient blood perfusion. Acidic pH has pleiotropic effects on cancer cell proliferation, clonal evolution/selection and metastasis, and also modulates immune cell functions. The processes of the pH gradient in cancer cells have recently become targets for anti‐cancer therapies.