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Multiple diclofenac-induced adverse effects

increased risk forH. pylori infection. One possible explanation for this increased risk for H. pylori infection in persons with a family history of gastric cancers may be the difference in the infectivity of H. pylori that causes gastric cancers and that which causes gastroduodenal ulcers. Indeed, there are many reports showing familial clustering of H. pylori infection in persons with gastric cancers, whereas reports of familial clustering of H. pylori infection in persons with gastroduodenal ulcers are scanty (10). This suggests the necessity of future studies concerning the difference in the infectivity of H. pylori as well as H. pylori virulence in variousH. pylori–related diseases.