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Protective action of alkylglycerols under stress

Abstract The adaptogenic properties of alkylglycerols (AGs) after 1 month’s treatment were investigated in a rat model of acute immobilization stress (AIS). The animals receiving AGs 157 mg/kg showed a body weight (BW) decrease in addition to a more pronounced increase in the adrenal glands index under stress conditions. Also, AGs at this dose prevented AIS-induced catalase inhibition. In addition, antiulcerative AG effects were already detected at a dose of 15 mg/kg. The data indicate that AGs promote adrenal gland activation in AIS. At the same time, AGs neutralize some of negative effects of stressful conditions, which include restoration of the oxidation–reduction balance, reduction of gastric mucosal stress lesion formation. LAY SUMMARY The effect of alkylglycerols, ether lipids from marine organisms, was studied in stressed animals. AGs have antioxidant activity and can be useful in the complex therapy of stomach lesions.