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Manganese Superoxide Dismutase Expression as a Function of Genotype and Lung Cancer Pathology

ABSTRACT Introduction: The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue. Methods: One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression. Results: The median normal MnSOD expression was 42% with a range of 10 to 70%, which was significantly greater (p = .001) than the median MnSOD expression in the tumor samples that was 18.8% and ranged from 1.1 to 50%. Conclusion: MnSOD expression is significantly reduced in lung adenocarcinoma and squamous cell carcinoma compared to the matched normal lung tissue.