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ATP‐ase activity of lymphocytes from normal individuals and patients with cancer

The lymphocyte ATP‐ase activity was significantly elevated in three groups of cancer patients compared to the activity of lymphocytes from normal individuals and patients with various nonmalignant diseases. Oligomycin inhibited and 2, 4 dinitrophenol stimulated the ATP‐ase activity of the lymphocytes from both groups, indicating a contribution of the mitochondrial ATP‐ase. Incubation of normal lymphocytes with phytohemagglutinin in vitro increased the oligomycin‐sensitive ATP‐ase activity of the cells considerably. It is suggested that the significantly elevated ATP‐ase activity of lymphocytes from cancer patients is probably due to an in vivo stimulation following a reaction between lymphocytes and tumor antigens.