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AB0153 CLINICAL SIGNIFICANCE OF MONOCYTE TO HEMOGLOBIN RATIO AND PLATELET TO ALBUMIN RATIO IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS

Background: Axial spondyloarthritis (axSpA) is a progressive, chronic, inflammatory skeletal disorder. Platelet to hemoglobin ratio (PHR) and platelet to albumin ratio (PAR) have been recommended as prognostic factor of cancer. However, none of study has focused on the clinical significance of PHR, PAR, neutrophil to hemoglobin ratio (NHR), neutrophil to albumin ratio (NAR), monocyte to hemoglobin ratio(MHR), monocyte to albumin ratio(MAR) for axSpA. Objectives: The study aims to determine the clinical significance of NHR, NAR, MHR, MAR, PHR, PAR for axSpA. Methods: A total of 198 axSpA patients and 48 healthy subjects were enrolled in the study retrospectively. Neutrophil, monocyte, platelet, hemoglobin, albumin, NHR, NAR, MHR, MAR, PHR, PAR, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were collected. AxSpA patients were divided into remission group (BASDAI<4) and active group(BASDAI≥4). Relationships between the parameters and BASDAI were assessed by the Sperman’ s correlations analysis. Receiver operation characteristic (ROC) curves were used to discriminate axSpA patients from healthy subjects and active group from remission group. Results: Neutrophil, monocyte, platelet, NHR, NAR, MHR, MAR, PHR, PAR, CRP, ESR in axSpA group were higher than those of control group, while albumin and hemoglobin were lower (P<0.05). ROC curve results showed that the AUC value of MHR for axSpA were 0.808 (CI95%: 0.738-0.878), yielding a highest AUC value than other parameters. The optimal cutoff value of MHR for axSpA was 0.002447, with the Youden index of 0.498, sensitivity of 87.4% and specificity of 62.5%. The closely positive correlations were found between PAR and BASDAI (r=0.379, P<0.001). Besides, platelet, NAR, MAR, PHR, PAR, CRP, ESR in active group were higher than those of remission group, while albumin were lower (P<0.05). ROC curve results showed that the AUC value of PAR for active group were 0.693 (CI95%: 0.610-0.775), yielding a highest AUC value than other parameters. The optimal cutoff value of PAR for active group was 5.967, with the Youden index of 0.354, sensitivity of 83.3% and specificity of 52.1%. Conclusion: MHR was elevated in axSpA patients with a highest diagnostic value. PAR was elevated in active axSpA patients, showing a significant correlation to the disease activity. References [1]Li Xing, Lin Zhi-Huan, Hong Ying-fen, et al. Platelet-to-hemoglobin ratio as a prognostic factor for hepatocellular carcinoma patients receiving transcatheter arterial chemoembolization.JOURNAL OF CLINICAL ONCOLOGY, 2016, 34(15): suppl. e15591 Acknowledgement: This study was supported by Medical Scientific Research Foundation of Guangdong Province (No. A2017551), Natural Science Foundation of Guangdong Province (No.2017A030313526) and Science and Technology Project of Guangzhou Haizhu District (Haike Business Infox 2018-89) Disclosure of Interests: None declared