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Continuous basal formation of endothelium-derived relaxing factor and muscle-derived relaxing factor, both of which are nitric oxide

The objective of this study was to ascertain the role of both the vascular endothelium and smooth muscle in the continous regulation of pulmonary vascular smooth muscle tone. Isolated rings of endothelium-intact and endothelium-denuded bovine pulmonary artery and vein were studied. Competitive inhibitors of nitric oxide (NO) synthase activity (N G -amino-L-arginine and N G -nitro-L-arginine) or NO action (hemoglobin) contracted arterial and venous rings in the presence or absence of endothelium, and contractile responses were accompanied by marked decreases in endogenous guanosine-3', 5'-cyclic monophosphate (cyclic GMP) levels.