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Blood-group gene frequencies in West Virginia.

The population of West Virginia, exclusive of the several metropolitan industrial areas, is probably more homogeneous than the population of most states in this country. The majority of residents in the rural areas and the small communities in the hollows trace their ancestry to Anglo-Saxon immigrants forced to venture west when there was no land available in the eastern regions. In contrast with most of the states in recent years, the population of West Virginia has been slowly declining (Metropolitan Life 1969). The loss has resulted both because people have left the areas where the declining coal-mining industry is the principal employer and because no new residents have come into these areas. The stability of the population may be appreciated by the findings in a survey of three semiisolated, rural, nonfarm, nonmine communities of central West Virginia; of the 136 households studied, the inhabitants of 47% had lived continuously in the area for more than 20 years and 65% had been there for 10 or more years (Chick et al. 1969). Gene frequencies of the blood groups have not previously been determined for a West Virginia population. The purpose of this report is to present the frequencies of the ABO, MNSs, Rhesus, Kell, Lutheran, Duffy, Lewis, P, and Kidd systems determined on 1,545 residents of the central and southern regions of the state.