{'fraction_non_alphanumeric': 0.016502697556331325, 'fraction_numerical': 0.006188511583624246, 'mean_word_length': 5.072254335260116, 'pattern_counts': {'":': 0, '<': 2, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Clinical evaluation of medhya rasayana compound in cases of non-depressive anxiety neurosis.

The data emerging out of the clinical trial indicated significant clinical relief and favourable shift of grades of the clinical components of anxiety namely nervousness, palpitation, insomnia, irritability, lack of concentration etc. Following Medhya Rasayana therapy. The elements of underlying depression as measured by a depression scale were also found reduced. The patients reported an increasing feeling of well being and showed a tendency of gain in body weight besides corrections of pulse rate and blood pressure.


Introduction:
Caraka has described four Classical Medhya Rasayana drugs in Cikitsa Sthana chapter 1 namely Sankhapuspi Mandukaparni, Guduci and Yastimadhu. The Medhya Rasayanas in general are considered as brain tonics besides their anti-anxiety activity as reported by Singh and associates (1977). The Four Medhya Rasayanas of Caraka Samhita have been studied individually by Sinha (1981) clinically as well as experimentally. The present study intends to undertake a clinical evaluation of the combined use of all the Four Medhya Rasayanas. Sinha (1981) reported that when evaluated individually only two of the Four Medhya Rasayana drugs namely Sankhapuspi and Mandukapatni act as significant anti-anxiety agents. The remaining two drugs namely Amrta and Yastimadhu did not show significant antianxiety effect on psychological parameters, However, it was postulated that these latter two drugs may have adjuvant effects of some unknown kind in Medhya Rasayana therapy. Therefore we thought to combine all the Four Medhya Rasayana drugs and use them in the form of a compound in the treatment of anxiety neurosis to assess the efficacy of the compound Medhya Rasayana as an antianxiety drug.

Materials and Methods
A series of 28 cases of Anxiety Neurosis were selected from Kayachikitsa outpatient department, S.S. Hospital, B.H.U. The patients were registered for the present study with the help of a proforma prepared for the purpose. Each case was interviewed individually and his basal condition was assessed on following parameters.

General Clinical Presentation:
The form of clinical presentation and the psycho-social background was worked out in each case.

2.
Clinical Anxiety Scale-was applied to measure the degree of clinical anxiety syndrome in terms of major symptoms produced by anxiety such as nervousness, palpitation insomnia, lack of concentration, irritability, headache, tremors anorexia and certain other features of gastrointestinal neurosis. The scale applied for the purpose gives a semiobjective measurement of the severity of the symptoms (Table 1).

Phychological and Biochemical
Studies: Each of this patients was evaluated for his physiological status in terms of B.P. pulse and body weight. Wherever possible we subjected these patients to biochemical investigations relevant to mental health.

Clinical Trial of Medhya Rasayana
After basal assessment of each case on above parameters the patients were subjected to the following schedule of therapy the efficacy of which was assessed on the following parameters Each patient selected for the trial was prescribed Medhya Rasayana Kasaya in the dose of 50gm in two divided doses 50gm crude dry drug was boiled with 800 ml water reduced to 100ml administered in two divided doses. The same treatment was continued for 6 weeks and the patients were reassessed every fortnight for the effect of treatment given on the following parameters adapting a self control system.

Results and Observations
1. Clinical Anxiety Scale -the subjective relief in these patients was recorded by quantitatively grading the major symptoms present in these patients such as nervousness, palpitation, insomnia, fatigue, dyspepsia, anorexia, lack of concentration, headache and irritability. Most of these symptoms were found quantitatively decreased after one month of treatment worth the trial drug. The grade scores of nervousness and headache showed maximum improvement (p<0.001) while lack of concentration and irritability showed moderate recovery (P<0.05) after 6 weeks of treatment (Table 3, 4).

Clinical Depression Scale -The
effect of the treatment was also assessed in terms of the degree of depression. As can be seen from the

General Health Improvement -
The patients reported a growing feeling of wellbeing and improvement in general health with increase in body weight during the course of Medhya Rasayana therapy. Such a feeling of wellbeing appears to be a secondary attribute to the anti-anxiety and adaptogenic effect of the trial drug besides its general restorative effects.

Discussion
As stated at the outset, the present investigation aims to undertake a clinical evaluation of the combined Medhya Rasayana therapy in Manas Roga. As anxiety forms the major component of almost all Manas Rogas, in the present context we   Vatanulomana always produce beneficial effects. As also observed by some of our colleagues, a regular mild Virecana therapy is an useful adjuvant in the care of mental patients.
Thus there are many benefits of combing four Medhya Rasayana drugs to develop a routine treatment for all forms of mental illness. The Medhya rasayana Kasaya use in the present trial is a simple cheap an safe remedy or all kinds of minor mental diseases. These drugs may be helpful even in major mental diseases if used in higher doses. However, it could be a best treatment as a maintenance therapy for mental patients including the patients of residual psychosis.
The present trial has shown no undesirable side effects in this drug and the treatment appears fairly safe and moderately effective. It is not possible to comment at this stage on the problem of addiction of these drugs because ours is only on a short term trial and we have not studied their withdrawal effects. Moreover, in view of the moderate activity and the general adaptogenic restorative effects the chances of addiction are minor. Thus the present study undertaken for clinical evaluation of Medhya rasayana therapy in Manas Roga has yielded evidence to suggest that the combined Medhya rasayana therapy is safe and moderately effective remedy for the care of a wide range of minor and moderate mental illhealth problem.