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Multimodal signal amplification by collaborative plasmonic intensification and catalytic multiplication (c-PI/CM)

Sensitive detection of specific chemicals on site can be extremely powerful in many fields. Owing to its molecular fingerprinting capability, surface-enhanced Raman scattering has been one of the technological contenders. In this paper, we describe the novel use of DNA topological nanostructure on nanoporous gold disk array (NPGDA) chip for chemical sensing. NPGDA features large surface area and high-density plasmonic field enhancement known as “hot-spots”. Hence, NPGDA chip has found many applications in nanoplasmonic sensor development. This technique can provide novel label-free molecular sensing capability with high sensitivity and specificity. In this paper, we introduce a new concept of multimodal signal amplification by exploring the synergy of catalytic multiplication and plasmonic intensification.