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Toward Facile Automated Glycan Synthesis: Current Progress and Remaining Challenges

Structure/function studies related to the biochemistry and molecular biology of carbohydrates has lagged those of proteins and nucleic acids in part due to the challenges in obtaining structurally well‐defined glycans. Fortunately, a 2012 report by the National Academy of Sciences1 outlining the specific problems has spurred investment by the U.S. National Institutes of Health through its Common Fund2 in developing the chemical methods and overcoming the building block limitations to make automated oligosaccharide synthesis widely available. Interestingly, individual investigators funded through this synthesis program are expected to coordinate and synergize efforts rather than work in isolation and to develop standardized, vetted protocols. This talk will discuss progress to date3 and the challenges still ahead in making a wide variety of discrete oligosaccharide structures readily available through automated methods.