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Chronic Alcohol Administration Induces Inflammasome Activation in Mouse Lungs

Excessive alcohol misusers are 2–4 times more likely to develop respiratory infections and acute respiratory distress syndrome as compared to non‐alcoholics. Alcohol misuse enhances oxidative stress in the lung, leading to impaired lung immunity. The molecular mechanisms by which this lung immune dysfunction occurs remain poorly defined. Inflammasome activation occurs in alcoholic steatohepatitis and functions in oxidative stress and host defense. Autophagy is critical for the engulfment and degradation of intracellular pathogens and regulates inflammasome activation. Thus, we hypothesized that autophagy prevents oxidative stress and inflammasome activation in the lung induced by alcohol.