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The Reliability of a Cytological Prediction of Cervical Adenocarcinoma In Situ

EDITORIAL COMMENT: The entity of cervical adenocarcinoma in situ will be new to many readers. This careful large study established that cytological prediction of adenocarcinoma in situ of the cervix is a very meaningful finding, with a false positive rate of only 2% i.e. 1 of 47 patients having adequate investigation; the other 46 patients having in situ (28) or invasive (18) carcinomas. The authors have justified their conclusion that a cytological report of adenocarcinoma in situ of the cervix merits further investigation by cone biopsy. The appropriate management of very early or minimal microinvasive adenocarcinoma discovered at conization performed following a cytological prediction of adenocarcinoma in situ remains controversial, until such time as long term follow‐up of a series of such patients is reported.