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Plasma concentrations of five proteinase inhibitors in healthy school-age children and in children with familial risk of ischaemic heart disease.

The plasma concentrations of five proteinase inhibitors (alpha 2-plasmin inhibitor, alpha 2-antitrypsin, antithrombin III, C1-inactivator, alpha 2-macroglobulin) in healthy school-age children were determined by electroimmunoassay. The concentrations of the same proteins were further determined in children with a familial risk of developing ischaemic heart disease. A significantly lower concentration of antithrombin III and a higher concentration of fibrinogen was found in this group.