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Autogenous Mineralized Dentin versus Xenograft granules in Ridge Preservation for Delayed Implantation in Postextraction Sites: A Randomized controlled clinical trial with an 18 months follow-up.

OBJECTIVES
To test primary stability of delayed implants placed in post-extraction ridges preserved with autogenous mineralized dentin matrix (MDM) versus xenograft granules. Clinical, histological and pain experience outcomes were further assessed.


MATERIAL AND METHODS
From March 2018 to July 2020, patients requiring ridge preservation in preparation for delayed implant placement in post-extraction sites were included. Participants were randomly allocated to either the test (MDM) or control group (xenograft granules) prior to ridge preservation. Visual analogue scale and analgesic consumption were measured every day for a week. Six months after preservation trephine cores were harvested for histomorphometry prior to implant placement. Implants were then placed and implant stability was measured immediately as well as two months after placement. Marginal bone loss, and presence of mucositis/peri-implantitis were registered up to 18 months after prosthetic loading.


RESULTS
Fifty-two patients (66 implants) completed the study. MDM and xenograft groups presented similar primary (77.1 ± 6.9 vs. 77.0 vs. 5.9) and secondary (81.8 ± 5.1 vs. 80.1 ± 3.8) implant stabilities. The percentage of newly formed bone in MDM (47.3%) was significantly higher than xenograft (34.9%) (p<0.001), and the proportion of residual graft was significantly lower (12.2% in MDM and 22.1% in xenograft) (p<0.001). No significant differences were found as far as clinical, radiographic and patient-related outcomes.


CONCLUSIONS
Implants placed in sites preserved with MDM had similar primary stability in comparison to xenograft granules. MDM showed a significantly higher quantity of newly formed bone and lower amount of residual graft in histomorphometry results and equal clinical and patient-related outcomes.