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Cimetidine the H2-receptor blocker: effect on the renal autoregulation in dogs.

Two groups of female mongrel dogs were examined. The renal perfusion pressure (RPP) was decreased to 100 then to 85 and to 75 mmHg. The following parameters were measured: renal blood flow (RBF), glomerular filtration rate (GFR), ultraviolet (UV), UNaV and UPo4V. In the first group the autoregulation was found to be intact as the RBF and the GFR were kept constant in the face of a decreasing RPP. In the second group cimetidine infusion 10(-6) M/min caused 11 per cent reduction in the RBF. Reduction of the RPP to 75 mmHg caused a significant decrease in the RBF by 30 per cent and the UV by 50 per cent, the GFR was stable. This work demonstrates the depressive effect of cimetidine on the total RBF and its autoregulation.