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Cytologic characteristics of oat‐cell carcinoma of the lung in relation to the effect of chemotherapy

The cytologic study of the effect of chemotherapy was performed in oat‐cell carcinoma of the lung. Cellular characteristics of tumor cells obtained by brushing via bronchoscopy were compared between responders (13 patients in complete and partial regressions) and nonresponders (13 patients with no response) treated with cyclophosphamide. The tumor cells in the responders more frequently showed finely granular chromatin evenly distributed throughout the nuclei. The tumor cells in nonresponders showed predominantly either deeply stained nuclei with coarsely granular chromatin distributed evenly or pale nuclei with unevenly distributed chromatin. These findings were also applied in the evaluation of the effect of combination chemotherapy. The nuclear chromatin pattern from oat‐cell carcinoma of the lung may be an indicator to predict the degree of response to chemotherapy.