{'fraction_non_alphanumeric': 0.02956989247311828, 'fraction_numerical': 0.008736559139784945, 'mean_word_length': 5.390557939914163, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Establishment and evaluation of physical and psychological stress‐induced PTSD animal model (1144.7)

It is well known that not only direct recipients but also the witnesses of traumatic events could suffer PTSD. However, there are no recognized animal models to mimic psychological stress induced PTSD. So we tried to establish psychological stress induced PTSD by communication box. Physical stress (foot‐shock, FS) was generated by receiving foot‐shock directly which mimicked the direct recipients of trauma, while psychological stress (non‐foot shock, PS) was generated by exposure to emotional responses without direct physical stress, for example, the visual and auditory stimuli that arose from foot shock stress rats, to mimic the witnesses of trauma. Serum corticosterone levels were increased three times 30 minutes after stress in both FS and PS rats, this result suggested that the modeling process was intense threat for both FS and PS rats. 21 days after trauma, we evaluated whether rats presented PTSD symptoms, like anxiety, high vigilance, avoiding trauma‐related cues and strong memory of trauma, by using elevated plus maze/ open field test, acoustic startle response test, ball (trauma related cue) burying test, and freezing time (re‐exposed to communication box) test. The results showed that about 40% FS rats and 30% PS rats could simulate PTSD clinical symptoms, and this animal model could be helpful to explore PTSD mechanism specifically and comprehensively.