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[Activity of angiotensin-converting enzyme in serum and its association with left ventricular mass and blood pressure level in patients with essential hypertension].

Renin-angiotensin-aldosterone system plays an important role in regulation of blood pressure and it is one of causative factors in left ventricular hypertrophy in patients with hypertension. The results of previous studies did not answer the question of the relation between elevated plasma angiotensin-converting enzyme (ACE) activity and presence of essential hypertension or left ventricular hypertrophy in hypertension. The aim of the present study was to compare plasma ACE activity in patients with hypertension and healthy subjects and to explore the relation between the level of blood pressure, left ventricular mass (LVM) and plasma ACE activity in patients with essential hypertension. The investigations were carried out in 21 patients with mild and 29 patients with moderate hypertension. Control group for the evaluation of plasma ACE activity was 28 healthy subjects. Plasma ACE activity was determined by spectrophotometric method. LVM was calculated on the basis of echocardiographic examination and was indexed to height (LVM/HT) and to body surface area (LVM/BSA). No significant differences in plasma ACE activity between patients with mild and moderate hypertension and healthy subjects were found out. Groups of patients with and without left ventricular hypertrophy did not differ significantly in plasma ACE activity. We did not find any relation between plasma ACE activity and left ventricular mass indexes as well as between plasma ACE activity and the level of systolic and diastolic blood pressure.