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Antitumor properties of thiazolo[4,5-b]pyridin-2-one derivatives

In this paper we present synthesis and antitumor activity determination of some thiazolo[4,5-b]pyridine-2-ones. In reactions conditions [3 +3]cyclocondensation, acylation and alkylation were synthesized the compounds 1-13. The study of the antitumor activity of the obtained substances was carried out within international cooperation whith the National Cancer Institute's (Developmental Therapeutic Program). For test compounds established moderate activity against most malignant tumor cells.