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Methodological Considerations on EEG Electrical Reference: A Functional Brain-Heart Interplay Study

The growing interest in the study of functional brain-heart interplay (BHI) has motivated the development of novel methodological frameworks for its quantification. While a combination of electroencephalography (EEG) and heartbeat-derived series has been widely used, the role of EEG preprocessing on a BHI quantification is yet unknown. To this extent, here we investigate on four different EEG electrical referencing techniques associated with BHI quantifications over 4-minute resting-state in 15 healthy subjects. BHI methods include the synthetic data generation model, heartbeat-evoked potentials, heartbeat-evoked oscillations, and maximal information coefficient (MIC). EEG signals were offline referenced under the Cz channel, common average, mastoids average, and Laplacian method, and statistical comparisons were performed to assess similarities between references and between BHI techniques. Results show a topographical agreement between BHI estimation methods depending on the specific EEG reference. Major differences between BHI methods occur with the Laplacian reference, while major differences between EEG references are with the MIC analysis. We conclude that the choice of EEG electrical reference may significantly affect a functional BHI quantification.