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Meta-analysis and narrative review confirm the benefit of essential phospholipids in non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD), also known as metabolic associated fatty liver disease or MAFLD, is one of the most common liver diseases worldwide. Although NAFLD is associated with metabolic risk factors, up to 40% of patients with NAFLD are not obese but can still be considered metabolically unhealthy. Current treatment recommendations for NAFLD focus on lifestyle interventions (weight loss, diet, exercise) since there are few if any accepted pharmacologic therapies. Essential phospholipids (EPLs) are recommended by some therapy guidelines as supportive treatment. A meta-analysis has now provided evidence to support this recommendation.