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Absence of Antidiuresis during Administration of Prostaglandin F2α

Water diuresis was induced in six patients in mid-pregnancy. Three were then given oxytocin and the remainder prostaglandin F2α (PGF2α), both drugs being infused intravenously in doses used to induce labour at term. Pronounced antidiuresis occurred with oxytocin, whereas PGF2α showed no such effect. The probable absence of any risk of water intoxication when using PGF2α in inducing labour may be of particular value when maternal pre-eclampsia or renal disease is present.