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Genetics of osteoporosis.

I. Introduction II. Determinants of Bone Mass III. Inherited Predisposition For and Against Osteoporosis IV. Genetic Factors in Bone Phenotype V. Vitamin D Receptor (VDR) Gene Polymorphisms and Bone Phenotype A. VDR gene polymorphisms and bone phenotype B. VDR gene polymorphisms and calcium homeostatic responses C. VDR gene polymorphisms, body size, and development D. Potential mechanisms for VDR allelic associations VI. Collagen Iα1 Gene VII. Other Candidate Genes and Chromosomal Loci VIII. Gene-Environment Interaction IX. Summary