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Alzheimer’s disease genetic risk variants show brain cell type‐specific associations with protein levels in cerebrospinal fluid

Neuronal dysfunction is central to the clinical manifestation of Alzheimer’s disease (AD). However, genome‐wide studies also suggest important roles for non‐neuronal brain cell‐types such as microglia and astrocytes. Our objective was to study whether brain cell type‐specific polygenic risk scores (PGRS) for AD, including single nucleotide polymorphisms (SNPs) of genes expressed in one brain cell type, showed relationships with levels of cerebrospinal fluid (CSF) AD markers in individuals across the clinical spectrum of AD.