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Knockdown of vitamin D receptor genes impairs touch-evoked escape behavior in zebrafish

Abstract Vitamin D is a steroid hormone well-known for its role in calcium homeostasis and bone health. Biological actions of vitamin D are mediated through the vitamin D receptor (VDR) present in various cells and tissues. Vitamin D has been implicated in multiple aspects of neuromuscular functions. This study aimed to investigate the role of VDR signaling during early stage of locomotor development utilizing a gene knockdown approach. Zebrafish larvae deficient in VDR showed severe motor impairment and no obvious response to touch. These results indicate that VDR signaling is indispensable for the correct neuromuscular development and touch-evoked escape swimming behavior in zebrafish.