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Combination of Saponins of Glycyrrhiza Uralensis Fisch(GS) and Platycodon grandiflorum A.DC(PS) for Duration of Effect

Objective:To evaluate the combination of saponins of Glycyrrhiza uralensis Fisch(GS) and Platycodon grandiflorum A.DC(PS) for duration of expectorant and anti-inflammatory effects.Methods:The duration of effects was observed directly in phenol drain model,xylene-induced mouse ear edema model and PLA_2-induced mouse paw edema model,and the combinative effects of two agents was evaluated quantitatively by Jin's Q formula.Results:Co-administration of GS and PS in 8∶1 can extend the duration of expectorant and anti-inflammatory effects,when compared to any agent alone.By the method of Jin's Q formula,additivity,synergism or antagonism was obtained in different models.Conclusions:GS and PS combined have characteristic of synergism in duration of expectorant and anti-inflammatory effects.The combinative ratio and total dose are two factors that can affect the combinative effects.