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Visceral Organ Cross‐Sensitization in a Rodent Model of Early Life Stress

Bladder pain syndrome (BPS) and irritable bowel syndrome (IBS) exhibit a high comorbidity, show a female predominance, and patients often report a history of early life stress (ELS). However, whether ELS serves as a risk factor for visceral organ cross‐sensitization remains to be determined. Our previous work suggests that multi‐organ visceral hypersensitivity results from visceral organ crosstalk. In this study, we test the novel hypothesis that ELS induces chronic visceral pain in adults through bladder‐colon crosstalk.