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Particle Shape Factors and Their Use in Image Analysis – Part 1 : Theory

INTRODUCTION Fine particle characterization is most effective when accomplished through a methodical process. The first step of this process often involves determining what material needs characterization. In general, the following instances are most often cited: • When a new chemical entity or active pharmaceutical ingredient is identified • When the production of an existing substance is changed (e.g., new salt form established, recrystalization process changed, milling parameters altered, etc.) • When there exists two lots or batches of virtually identical material that behave differently in some manner.