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Fas gene expression and apoptosis during acute rejection in rat kidney allograft

Aim:To investigate the relationship between Fas gene expression and cell apoptosis during acute rejection in rat kidney allograft. Methods: Rat renal allograft model was contructed. Immunohistochemistry was used to detect the expression of Fas gene. In situ labeling apoptotic DNA fragment detection(TUNEL) was used to detect renal allograft tubule cell apoptosis.Results: Fas protein was negative or weakly expressed in normal rat kidney, whereas Fas protein expression was significantly increased in renal allografts during acute rejection. There was a positive correlation between Fas gene expression and renal allograft tubule cell apoptosis( r s=0.512, P 0.001).Conclusion: Overexpression of Fas gene may lead to renal allograft tubule cell apoptosis, renal structure injury and loss of function.