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Analysis of a Case of Brugada Syndrome Through Numerical Simulation of Ventricular Action Potential

Brugada syndrome (BrS) is a disorder characterized by cardiac conduction system dysfunctions, which increases the risk of sudden cardiac death, without heart structural alterations. The diagnosis is based on the ECG tracing analysis: BrS patients have common anomalies. The typical ECG pattern, however, can remain latent and patients can be asymptomatic: the first symptom often coincides with death. Recently, a new mutation associated with BrS has been identified and characterized by HEK 293 cells. This study aims to analyse, through numerical simulation of the O ‘Hara-Rudy (ORd) model, the mutation effects on the ventricular action potential (AP). Under normal conditions, the simulation results do not show significant alterations in the mutant AP. For this reason, we hypothesized that the pathological BrS phenotype could be triggered by other factors.