{'fraction_non_alphanumeric': 0.01889763779527559, 'fraction_numerical': 0.015748031496062992, 'mean_word_length': 5.050793650793651, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Supralox: a novel aluminium containing antacid with gastroprotective and ulcer healing activity

Objective: To examine the gastroprotective and ulcer healing properties of Supralox, a novel antacid which resembles Maalox 70 but contains about three times less aluminium per dose. Design: The protective effects of Supralox were determined using acute gastric lesions induced by 100% ethanol or acidified aspirin (ASA) while the healing action of this agent was tested using chronic gastric ulcers induced by acetic acid. Methods: Supralox was given intragastrically in graded doses 30 min before 100% ethanol or acidified ASA, or administered intragastrically after induction of acute lesions with acidified ASA and chronic gastric ulcers with acetic acid. Results: Supralox reduced the formation of acute gastric lesions induced by 100% ethanol and acidified ASA in a dose dependent manner. The ED50 was 53 and 90 mg/kg, respectively. The protective efficacy of Supralox was similar to that of Maalox 70 and 16, 16-dimethyl prostaglandin E2. The protection against ethanol- and ASA-induced mucosal lesions obtained with Supralox was enhanced when it was acidified to a pH value of 2.0. Supralox given alone at its native or acidic pH caused an increase in the gastric blood flow (GBF) in the intact stomach and partly prevented the fall in GBF caused by ethanol and ASA. Supralox accelerated the recovery of the gastric mucosa from ASA-induced damage and this was also accompanied by an increase in the GBF. Supralox increased the rate of healing of chronic gastric ulcers in rats with or without administration of indomethacin. This was accompanied by an increase in GBF at the ulcer margin. Similar ulcer healing effects were obtained with Maalox and omeprazole. Conclusion: Supralox is a novel aluminium containing antacid with gastroprotective and ulcer healing efficacy similar to that of Maalox 70.