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Initial experience of fecal microbiota transplantation in Belarus in patients with hematologic malignancies as a method for recovery of intestinal microbiocenosis

This article describes the first attempt of fecal microbiota transplantation for correction of gut microbiota in two patients suffering from hematologic malignancies made in the Republic of Belarus. Partial clinical response to the procedure was observed in the both patients. We  detected positive changes in the gastrointestinal tract state and a decrease  in the abundance of multiresistant bacteria. In addition, microorganisms from donor microbiota were observed in intestinal microbiota of the patients. However, the positive effects of fecal microbiota transplantation disappeared after re-initiation of chemotherapy and antibiotics treatment. Further research is required to improve the procedure effectiveness in patients   with hematologic malignancies.