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Anti‐atherosclerotic property of emu oil in diet induced obese rats

The present study was aimed to test the oil obtained from Emu bird Dromaius novaehollandiae for its anti‐atherosclerotic activity in diet induced obese (DIO) rat. Animals were divided into five groups randomly, normal diet group (ND), high fat diet group (CD), high fat diet plus emu oil 2.0 ml/kg BW (ED1), high fat diet plus emu oil 4.0 ml/kg BW (ED2), high fat diet plus emu oil 8.0 ml/kg BW (ED3). Oral treatment for 12 weeks was carried out. Body weight, liver and adipose tissue weight were measured, lipid profiles, C‐reactive proteins (CRP) followed by histopathology of thoracic aorta were carried out to confirm the anti‐atherosclerotic effect of emu oil. Sex hormones such as testosterone and luteinizing hormone were also measured. Results obtained revealed that emu oil supplementation reduced the lipid profiles and modulated the hormonal profiles, followed by reduced formation of atheromatous plaque or thickening of thoracic aorta, also there was a significant decrease in the body weight along with liver and adipose tissue weight indicating the significant anti‐atherosclerotic activity of emu oil. To conclude, we believe that high content of oleic acid could have orchestrated either solely or in combinations with other fatty acids such as linoleic and linolenic acids present in the emu oil towards up regulating testosterone biosynthesis and averting the atherosclerosis formation in diet induced obese animals.