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Effects of Infrasound on the Proliferation and the Expression of BDNF in the Hippocampus

To explore the effects of infrasound on the memory function and neurogenesis in the rat hippocampus, BDNF and BrdU-labled neurons were investigated by the immunohistochemical method. After exposure to infrasound of 8Hz, 130dB for 14 days, the Morris water maze test was performed to assess spatial learning and memory. The rats were sacrificed and sections of hippocampus were stained for BrdU and BDNF. The infrasound exposure obviously extended the latency to find the platform, and decreased the number of BrdU-labled cells and BDNF -like neurons in the hippocampus. These results indicated that infrasound may interfere the memory function which the decrease of BDNF and neurogenesis cells in hippocampus might be involved in.