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GNA/aegPNA chimera loaded with RNA binding preference.

Peptide nucleic acid (PNA) is an oligonucleotide mimic, in which the sugar-phosphate backbone is replaced by a pseudo-peptide skeleton, composed of N-(2-aminoethyl)-glycine (aeg) units carrying nucleobases via methylene carbonyl linkages (Figure 1 a). Owing to its neutral amide backbone, aegPNA has outstanding chemical and enzymatic stability as well as high binding affinities to DNA and RNA, which gives it great potential for development as an antisense agent or diagnostic tools in a chip-based assay.