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Aceruloplasminemia: Neurodegeneration with brain iron accumulation associated with psychosis

Inborn errors of metabolism (IEM) are associated with various psychiatric manifestations. As reported by Trakadis et al., psychosis can be a predominant feature or even isolated presenting manifestation of IEM (Trakadis et al 2018). We read with great interest the authors' overview of IEM that may be phenotypically difficult to distinguish from psychiatric illness. Within the group of metal storage disorders, pantothenate kinase-associated neurodegeneration (PKAN) and neuroferritinopathy represent two forms of neurodegeneration with brain iron accumulation (NBIA) that have been associated with psychosis. However, aceruloplasminemia should also be included in the list of NBIA diseases that merits consideration in the differential diagnosis of unexplained psychosis. This article is protected by copyright. All rights reserved.