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GENETIC INTERACTIONS PROVIDE EVIDENCE FOR THE ROLE OF INTEGRINS IN SPECIFYING NORMAL OLFACTORY BEHAVIOR IN DROSOPHILA MELANOGASTER

In a previous paper, we showed that weak hypomorphic alleles at the myospheroid ( mys ) locus, which encodes the β-subunit of integrin, possess defects in olfactory behavior in both adult and larva. In this paper, we show that another olfactory gene, olfE , exhibits haploinsufficient interactions with recessive alleles at the mys locus. olfE has recently been shown to be an allele of swisscheese and is now designated as sws olfE . Our findings suggest an interaction between the sws protein and β-integrin in the development and/or functioning of the olfactory system. Similar interactions were also observed between sws and inflated , a gene encoding the α2-subunit of integrin, as well as mys and multiple edematous wing ( mew ), a gene coding for α1 subunit of integrin. This study provides evidence for the roles of different integrin subunits and the sws product in regulating normal olfactory behavior in Drosophila .