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Verifying the hypothesis of overwork weakness in Charcot-Marie-Tooth.

J Rehabil Med 2010; 42: 380–381significantly stronger, non-dominant hand for the tripod pinch. We agree with Videler that the latter finding may fit with the hy-pothesis of overwork weakness. However, it should be noted that the difference in strength between both hands for the tripod pinch is relatively small and that the non-dominant hand is also severely weakened. Therefore, it is unclear if this difference is clinically relevant. As suggested by Videler et al., larger prospective cohort studies or interventions studies, preferably using more specific measures of intrinsic hand muscle function (e.g. (7)) would be needed to conclude on the presence of overwork weakness.