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Transplants of immature astrocytes promote axonal regeneration in the adult rat brain

To study beneficial effects of immature astrocytes on axonal regeneration in the injured adult mammalian brain, we have stereotactically implanted cultured astrocytes from embryonic (E 14–16) rat cerebral cortex into the lesion site following transection of the postcommissural fornix. The spatio‐temporal pattern of axonal degeneration and regrowth in the proximal fornix stump was investigated using wheat germ agglutinin‐horseradish peroxidase tracing techniques and quantitative analysis of myelinated axon profiles.