{'fraction_non_alphanumeric': 0.05534204458109147, 'fraction_numerical': 0.04073789392774789, 'mean_word_length': 4.540425531914893, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
17: The effect of hyperparathyroidism on tubular reabsorption of amino acids in vitamin D resistant rickets (VDRR)

The tubular reabsorption of amino acids was investiqated in 15 children with VDRR before treatment, following an acute injection of PTH, and after development of secondary hyperparathyroidism Induced by continous oral phosphate substitution. Before treatment 5 of 6 children had normal serum values of iPTH ( 22,5 U/ml ). None of 15 patients showed a generalized defect in amino acid reabsorption, however tubular reabsorption of glycine was significantly reduced in 10 patients ( %T-gly = 90,7 % vs. 96,5 % in normals ). After an acute i.v.application of 200 IU PTH there was no change in reabsorption of total amino acids ( %T-AA = 98,0 %) nor in glycine ( %T-gly =91,0% ). Under treatment with oral phosphate and vitamin D 5 out of 10 children developed secondary hyperparathyroidism within 12 months (iPTH= 100,7 U/ML) while 5 patients had normal values ( iPTH = 12,4 U/ml ) In both groups the %T-AA ( 97,6% and 98,4% resp.) and %T-gly ( 91,3 % and 92,3 % resp. ) were unchanged compared to the values before treatment. The results indicate, that acute and chronic hyperparathyroidism is not followed by hyperaminoaciduria In VDRR, as is postulated in vitamin D deficiency rickets.