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Multiplexed polymer surface plasmon sensor with integrated optical coupler

In this paper, we describe a novel multiplexed surface plasmon resonance (SPR) sensor which is made of cyclic olefin copolymers (COCs, TOPASTM). This material has excellent chemical resistance, low water uptake (< 0.01%), and high refractive index (nHe-Ne=1.53) suitable to use as an optical coupler (prism) as well as a sensor substrate. We fabricated a standard slide glass sized, prism integrated, and injection molded COC-SPR sensor which are being applied toward the multiplexed detection of DNA single nucleotide polymorphism (SNP). To evaluate the sensitivity of COC-SPR sensor, we first patterned MgF2 on gold-coated COC-SPR sensor and observed the shift of minimum reflectivity (SPR dip) in pixel address. As incident light source we used an expanded, collimated, rectangular shaped He-Ne laser, with a diffuser for beam homogenization. With expanded laser beam we varied incident angle so that the angular shift is expressed as the darkest pixel shift on CCD. For optimized SPR characteristics and sensor configuration, analytical calculations (Fresnel equation) were performed, and the best SPR conditions were found to be dAu~48 nm at wavelength λ=633 nm with respected resonance angle at θSPR =44.2° for COC-SPR sensor.