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Meningeal inflammation in multiple sclerosis

Cortical demyelinating lesions are a common pathologic feature of multiple sclerosis (MS), an immune-mediated inflammatory and degenerative disorder of the CNS. Most knowledge on cortical demyelinating lesions in MS derives from neuropathology, which demonstrated that cortical lesions, though more commonly observed in progressive MS, may occur from the earliest stages of the disease, seemingly independent of lesions in white matter (WM).1–4