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Diagnostic and Prognostic Significance of Complement in Patients With Alcohol‐Associated Hepatitis

Given the lack of effective therapies and high mortality in acute alcohol‐associated hepatitis (AH), it is important to develop rationally designed biomarkers for effective disease management. Complement, a critical component of the innate immune system, contributes to uncontrolled inflammatory responses leading to liver injury, but is also involved in hepatic regeneration. Here, we investigated whether a panel of complement proteins and activation products would provide useful biomarkers for severity of AH and aid in predicting 90‐day mortality.