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Negative feedback control of gonadotropin secretion by chronically administered estradiol and porcine follicular fluid (gonadostatin) in ovariectomized rats.

This study examines the roles of 17β-estradiol, progesterone, and gonadostatin in the negative feedback control of FSH and LH secretion. Four groups of long term ovariectomized rats were injected daily with 1.0 ml porcine follicular fluid (pFF) on days 15–21 post ovariectomy. Group one was implanted with a blank Silastic capsule from days 8–28 to study the effect of chronic exposure to pFF alone. Group 2 was implanted with an estradiol capsule from days 8–15 to examine any priming action that estradiol might have on the suppression of serum FSH by gonadostatin. Group 3 was implanted from days 15–28 with an estradiol capsule (i.e. simultaneous initiation of estradiol and pFF treatment). Group 4 was implanted with an estradiol capsule from days 8–28 to study the effect of chronic exposure to the combination of estradiol and pFF. Blood samples were collected at 1400 h on days 14, 15, 16, 18, 21, and 28 by cardiac puncture and assayed for FSH, LH, and estradiol. There were five main findings: 1) neither estra...