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Effects of healthy aging on internal brainstem structure

The brainstem is a complex structure and is often affected in the earliest stages of a neurodegenerative diseases. However, internal brainstem structures are not delineated on standard MR sequences complicating the differentiation between healthy aging and an incipient neurodegenerative process in‐vivo. The overall goal of this project was to characterize age‐related atrophy of different brainstem structures using a modification of a previously published multi‐contrast brainstem segmentation approach (1) using standard MR sequences.