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Unsupervised clustering for phenotypic stratification of clinical, demographic, and stress attributes of cardiac risk in patients with nonischemic exercise stress echocardiography

Patients undergoing exercise echocardiography with no evidence of myocardial ischemia are considered a low‐risk group; however, this group is likely heterogeneous in terms of short‐term adverse events and subsequent cardiac testing. We hypothesized that unsupervised cluster modeling using clinical and stress characteristics can detect heterogeneity in cardiovascular risk and need for subsequent cardiac testing among these patients.