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The human platelet fibrinogen receptor: clinical and therapeutic significance.

Thrombotic disorders are a major cause of morbidity and mortality and the basic mechanisms of thrombus formation have therefore been an important area of therapeutic research for several decades. Thrombi consist largely of platelets and fibrin and the interaction between these two elements comes at the end of a complicated clotting cascade. Platelets are a source of several factors essential for the efficiency of the clotting process including fibrinogen and von Willebrand factor (vWF) as well as providing phospholipid for intermediate stages in the coagulation cascade and the production of prostaglandins which are both platelet stimulants and vasoactive. The pivotal and final role of the platelet in clot formation is related to the interaction of fibrinogen with a specific binding site or 'receptor' on the platelet surface membrane. In this review we will examine the functional significance of the platelet fibrinogen receptor and its clinical and therapeutic relevance.