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Albumin Excretion by the Kidney: The Effects of Furosemide Diuresis 1

Summary UalhV in the female Sprague-Dawley rat was measured during a stable period of normal hydration and following furosemide-induced diuresis with the simultaneous replacement of diuretic fluid losses. Furosemide administration resulted in a significant increase in V and FENa, but GFR, UalbV, and the sieving coefficient for albumin remained stable. The results suggest that, under physiological conditions, changes in albumin excretion are dependent upon changes in glomerular filtration rather than urine flow.