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Automation of the tear film break-up time test

The Break-Up Time test (BUT) evaluates the quality and stability of the tear film. It is used for the diagnosis of the dry eye syndrome, a widespread disease in the developed world. This paper describes an automatic methodology to evaluate the BUT test. This methodology locates the different measurement areas from a video of the tear film, extracts the region of interest and performs the BUT test in each measurement area. We have tested our methodology on a dataset composed of 18 videos annotated by 4 different experts. The difference between the automatic measurement and the value provided by the experts is in the same range as between the experts themselves.