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Impaired estrogen‐induced negative feedback on gonadotropin secretion in patients with gonadotropin‐secreting and nonfunctioning pituitary adenomas

Background Several in vitro studies suggest that gonadotropin‐secreting pituitary adenomas (Gn‐omas) and non functioning pituitary adenomas (NFPA) originate from gonadotroph cells. Patients with Gn‐oma and NFPA frequently show abnormal gonadotropin response to TRH. The aim of the study was to investigate whether the estrogen‐induced negative feedback is operating in either patients with Gn‐oma or NFPA.