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[Kinetics of T- and B-lymphocytes in the lymph nodes of human fetuses].

Investigations of the lymph nodes embryogenesis had mainly an anatomo-histological character. At the present time a new approach is necessary: elucidation of main immunological characteristics of lymphoid elements, occupying lymph nodes already at early stages of ontogenesis. The aim of the investigation was to study marker composition of lymphocytes, occupying the lymph nodes of various regional groups, that are in anatomical and functional connection with the thymus, Waldeyer-Pirogov lympho-epithelial pharyngeal ring, appendix and Peyer's patches. The anterior, mediastinal, ileocecal and deep cervical lymph nodes have been studied in 23 human fetuses 17-28-week-old. Immunological and morphological peculiarities of development have been followed in the groups of the lymph nodes mentioned. According to the expression of superficial markers the character of heterogeneity in T- and B-cell systems and their kinetics during embryogenesis has been stated to be characteristic for each regional group. In all lymph nodes the number of T-lymphocytes predominate, their greatest content is noted in the ileocecal lymph nodes. The B-lymphatic system in the lymph nodes is presented poorly with its predominance among immunoglobulin-positive lymphocytes of Ig M(+)-cells.