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On the issue of accelerated hygienic assessment of environmental genotoxic carcinogens.

OBJECTIVE
The aim of the work was assessment of the criterial significance of the complex of early immunological reactions of the organism, pathomorphological and genotoxic changes in the organs for the acceleration of testing and hygienic assessment of carcinogenic danger of chemical substances.


PATIENTS AND METHODS
Materials and methods: Investigations were carried out in the chronic experiment on white random-bred male mice and included 2 series of the investigations: 1 - application of benz(a)pyrene on skin in different doses (10.5µg; 2.1µg; 0.21µg); 2 - peroral administration of benz(a)pyrene and phenol (single dose - 0.1 mg). Genotoxic changes in skin and forestomach were assessed with the help of micronuclear test.


RESULTS
Results: Under carcinogen exposure, regardless of routes of administration we determined an increase frequency of the cells with micronuclei and suppression of T-link ofimmune system during the first month which were characterized by a parallelism of development, unidirectional relative to carcinogenesis and presence of reliable reverse correlative connection between them. In the period between the 1t and the 3d months we observed a stabilization of the number of cells with micronuclei and deepening of immunosuppression at the expense of the suppression of humoral chain of the immunity.


CONCLUSION
Conclusions: The obtained data became a basis for the development of methodic scheme of accelerated testing of the chemical substances under investigations for carcinogenicity and hygienic setting of genotoxic carcinogens.