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Regio- and Diastereoselective [3 + 2] Annulation of Aliphatic Aldimines with Alkenes by Scandium-Catalyzed β-C(sp3)-H Activation.

Here we report for the first time the regio- and diastereoselective [3 + 2] annulation of a wide range of aliphatic aldimines with alkenes via the activation of an unactivated β-C(sp 3 )-H bond by half-sandwich scandium catalysts. This protocol offers a straightforward and atom-eﬃcient route for the synthesis of a new family of multi-substituted aminocyclopentane derivatives from easily accessible aliphatic aldimines and alkenes. The annulation of aldimines with styrenes exclusively afforded the 5-aryl- trans -substituted 1-aminocyclopentane derivatives with excellent diastereoselectivity through the 2,1-insertion of a styrene unit. The annulation of aldimines with aliphatic alkenes selectively gave the 4-alkyl- trans -substituted 1-aminocyclopentane products in a 1,2-insertion fashion. A catalytic amount of an appropriate amine such as adamantylamine (AdH 2 ) or dibenzylamine (Bn 2 NH) showed significant effects on the catalyst activity and stereoselectivity.