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Role Of Free / Total Psa Ratio To Differentiate Bph And Prostate Cancer

This study was undertaken to determine Free to Total PSA ratio to differentiate between Benign Prostate Hyperplasia (BPH) and Prostate Cancer (PCa) and to improve the accuracy of the PSA test and the specificity of PCa detection particularly when PSA levels fall between 4-10ng/ml levels. The study group consisted of a total of 124 subjects. Free PSA and Total PSA were determined using assay, which is based on Chemiluminescent Microparticle Immunoassay (CMIA) technology. The Statistical test used were Students’ t test for difference of Mean and Pearson Correlation test, using SPSS and MS Excel Statistical packages. Free/Total PSA ratios in the prostate cancer group were significantly lower than those in the BPH group. A cut-off of F/T PSA ratio% at 18% improves diagnostic sensitivity and specificity for prostate cancer.