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Desensitization and resensitization are independently regulated in human recombinant GluR subunit coassemblies

AMPA‐type glutamate receptor (GluR) channels are the most abundant excitatory transmitter receptors of the central nervous system. Four subunits with different posttranscriptional modifications and flip/flop splice variants are known. In vivo they occur as tetrameric heteromeric receptors. In the present study we analyzed the time course of desensitization (τD) and resensitization (τrec) kinetics of different homomeric (coassembly of splice or editing variants of one subunit) and heteromeric (coassembly of different subunits) GluR channels. We found that τD had intermediate values depending on the amount of cDNA of the respective subunit at all heteromeric and homomeric GluR channels tested. The same holds true for τrec except GluR2 flip channels were coexpressed with GluR1 channels. In this case, τrec had values close to that of fast resensitizing GluR2 flip channels, even in the case of an abundance of GluR1 cDNA. Synapse 55:176–182, 2005. © 2005 Wiley‐Liss, Inc.