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[Experimental approaches to research role of genotype in locus TAG 1A of gene receptor dopamine second type in narcotic dependence].

The aim of this study was investigation into influence of genotype in locus TAG 1A of gene receptor dopamine second type on mechanisms forming narcotic dependence. Study of water schedule and behavior in "open field" test before and after compulsory alcoholization was performed on two groups of adult rats with genotypes A1/A1 and A2/A2 in locus TAG 1A. The results obtained suggest the effect that allele A1 (or genotype A1/A1) in locus TAG 1A of gene receptor dopamine second type exerts upon accelerated development of alcohol tolerance and forming of narcotic dependence. These results also confirm previously obtained data on association of allele A1 in locus TAG 1A of gene receptor dopamine second type with hard clinical course of alcoholism and narcotic dependence.