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Assessment of renal function from plasma creatinine in adult patients.

The diagnostic value of four different delimitations of plasma creatinine concentrations to assess whether—and to what extent—the combined function of the two kidneys is affected by disease was evaluated from simultaneous determination of plasma creatinine and glomerular filtration rate (GFR) in 380 adult patients (200 females and 180 males aged 20-79 years) and from the prevalence of four different degrees of relative renal function in a consecutive series of 578 patients with different nephro-urological disorders. The four degrees of relative renal function (with the delimitations expressed as per cent of corresponding age- and sex-dependent normal mean GFR) were as follows: normal (>75%); moderately decreased (75-52%); considerably decreased (51-28%); and severely decreased ( 250 in females, and <128; 128-1...