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Effects of Sodium Poly(styrene sulfonate) on Antibody Production and Cell Growth of HB4C5 Hybridoma Cells

The effects of sodium poly(styrene sulfonate) on an antibody production and cell growth of a hybridoma cell were studied. Although sodium poly(styrene sulfonate) inhibited the antibody production and cell growth at lower concentration with increasing molecular weight in serum-free cultures, sodium poly(styrene sulfonate)s with medium weight-average molecular weights (Mw) such as 35000 and 18000 suppressed antibody production without inhibiting cell growth at appropriate concentrations. Sodium poly(styrene sulfonate) (Mw=35000) decreased the extracellular concentration of a μ heavy chain forming an antibody, while it had no effect on an intracellular antibody or μ heavy chain concentration. This suggests that the sodium poly(styrene sulfonate) suppresses secreting the antibody assembled by μ heavy chains and λ light chains out of the cell without inhibiting the synthesis and association of both chains in the cell.