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Monitoring in Clozapine Rechallenge After Myocarditis

On day 26 post-rechallenge, while the patient was on a daily clozapine dose of 137.5 mg, a troponin rise to 0.04 μ g/L was noted. The troponin level peaked at 0.17 μ g/L and returned to normal within one week. This coincided with mild elevation in CRP that peaked at 16.2 mg/L. During this time, three echocardiography studies were performed, all of which showed normal systolic function and the dose of clozapine was maintained at 137.5 mg daily. The patient did not complain of any cardiac symptoms and no remarkable fi ndings were noted on physical examination or ECG.