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Genetic susceptibility to colorectal cancer in patients under 45 years of age

on report. The incidence of bacteraemia following lower GI endoscopy has been reported as ranging from 1-27 per cent in a recent review’. Bacteria entering the portal blood during large bowel endoscopy are filtered out by the liver, hence the low reported incidence as they are not detected so readily in the systemic circulation’. As described in the report, the patient presented with pneumaturia; this constitutes a ‘high risk‘ in our opinion, because there is an appreciable ‘septic’ complication rate in such patients. There have been no ‘sporadic’ cases of portal pyaemia reported in the literature following flexible sigmoidoscopy, and we believe routine antibiotic prophylaxis in such cases is reasonable.