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Effects of Anticonvulsants on Human P450c17 (17α‐Hydroxylase/17,20 Lyase) and 3β‐Hydroxysteroid Dehydrogenase Type 2

Summary:  Purpose: Women with epilepsy apparently have a higher incidence of polycystic ovary syndrome (PCOS) than do women without epilepsy. Whether the underlying disease or the antiepileptic drug (AED) treatment is responsible for this increased risk is unknown, although clinical reports implicate valproic acid (VPA) as a potential cause. The steroidogenic enzymes 3βHSDII (3β‐hydroxysteroid dehydrogenase) and P450c17 (17α‐hydroxylase/17,20 lyase) are essential for C19 steroid biosynthesis, which is enhanced during adrenarche and in PCOS.