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Four-Component Reaction between Cyclohexyl Isocyanide, Aromatic Aldehydes, Aromatic Amines and Trifluoroacetic Anhydride

Reaction of cyclohexyl isocyanide with aromatic aldehydes, aniline derivatives and trifluoroacetic anhydride in dichloromethane at room temperature afforded N-[cyclohexylcarbamoyl(aryl)methyl]-2,2,2-trifluoro-N-arylacetamide derivatives in nearly quantitative yields after 10 min. The work-up procedure is very easy and the products are precipitated in ether as pure solids. The structure of one of the products was established by X-ray single crystal analysis.