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Enzymatic Synthesis of Peptides with Hydrophilic Amino Acid in Water‐Miscible Organic Solvent

An enzymatic synthesis of peptides catalyzed by proteinases has been extensively investigated in some solvent systems. We have successfully synthesized some peptides containing hydrophobic amino acids in high yields using an aqueous-organic biphasic system.’,, It is, however, not easy to synthesize peptides consisting of hydrophilic amino acids without protective groups of their side chains. Hydrophilic peptides are excellent in solubility to water and favorably improve the taste of food.3 In this context, we have attempted to synthesize peptides including a hydrophilic and basic amino acid lysine, which is one of the essential amino acids, through transesterification catalyzed by trypsin. The overall reaction scheme is as follows: