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SERUM URIC ACID, CARDIOVASCULAR DISEASE, AND ALL CAUSE MORTALITY; IMPACT OF GENDER, BLOOD PRESSURE, RENAL FUNCTION AND CARDIOVASCULAR RISK FACTORS. THE TROMSØ STUDY 1994/95: PP.7.268

Objective: There are conflicting data concerning the role of serum uric acid (SUA) as independent predictor of cardiovascular disease (CVD) and death in the general population, possibly because confounding factors such as gender, blood pressure and renal function have been insufficiently accounted for. We examined the associations of SUA with death and CVD, adjusting for glomerular filtration rate (eGFR) and other CVD risk factors. Design and Methods: Population-based prospective cohort study where SUA was measured in 2853 men and 3139 women (age; 60±10 years). Twelve-year all-cause mortality and 10-year occurrence of fatal or non-fatal myocardial infarction (MI) or stroke were examined with genderspecific Cox regression analyses. Results: SUA was 316±88 μmol/L (mean±SD, men; 358±86, women; 278±72 μmol/L). The number of person-years was 76 368 for all-cause mortality, 59 476 for MI and 60 336 for IS. Altogether, 1431 deaths, 673 MI's and 343 strokes occurred during follow-up. Figure 1. No caption available. Significant interaction was seen between gender and the association og SUA with all-.cause mortality (p < 0.001). Conclusion: SUA is associated with stroke in both genders, even after adjustment for blood pressure, renal function and other cardiovascular risk factors. After this adjustment, SUA is associated with MI in men only, and with all-cause mortality only in women.