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DEVELOPMENT OF THE TECHNOLOGY OF GRANULES WITH THE POLYFRACTION EXTRACT ALFREDIA DROOPING (ALFREDIA CERNUA L.)

Abstract: Alfredia drooping is a source of vegetable raw materials with cerebroprotective, antioxidant and antiradical effects. We obtained a dry polyfraction extract from the lower, petiolate leaves of Alfredia. The purpose of the research is to develop a technology of water-soluble granules based on a polyfraction extract of Alfredia drooping dry for the preparation of a drink. We used polyextract from the leaves of alfredia drooping and water-soluble excipients: maltodextrin DE 12-19, starch sodium glycolate, sodium chloride and sucrose, ethyl alcohol 95% as objects of research. The wet granulation method was used to produce pellets. The technology of the granules consisted in the fact that all the components of the granules (humidity no more than 2%) were mixed, moistened with 95% ethyl alcohol and granulated by pressing through the mesh (holes 2 mm). The granules was dried at a temperature no higher than 30°C to a residual humidity of no more than 2%. The granules were then re-granulated and sieved through a sieve (2 mm holes).In the course of research, the product was evaluated according to the indicators "granulation ability", "disintegration", "uniformity of dosing", "dissolution", "taste". The composition of granules with alfredia polyextract was determined as a result of experiments: polyextract: maltodextrin: sugar: calcium glycerophosphate: starch sodium glycolate: sodium chloride in the ratio 1,41:0,8:1,2:0,16:0,16:0,13 g, respectively. The obtained granules have withstood all tests according to the indicators provided for by GF 14 of the edition: "description", "size of granules", "loss in mass during drying", "disintegration", "uniformity of mass", "microbiological purity". The shelf life for granules with Alfredia extract can be set for a duration of 18 months.