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Vision‐Related and Health‐Related Quality of Life in Patients with Giant Cell Arteritis

visual acuity (BCVA), low-contrast sensitivity (LCS), color vision and 30° automated perimetry (30°AP). RGC structure was assessed by macular GCL thickness on OCT. Results: PIPR and PhNR were significantly reduced in the diabetic compared to control group (p < 0.0001 and p = 0.0046), as were the visual tests: BCVA (p = 0.0466), LCS (p < 0.0001), color vision (p = 0.01), 30°AP mean sensitivity (p = 0.0004). PIPR and PhNR both correlated with GCL thickness (p = 0.05 and p = 0.015). There was a correlation between the DR grade and PFD on OCTA (p = 0.046). Both PIPR and PhNR correlated with PFD (p = 0.028 and p = 0.006). Conclusions: PIPR and PhNR are reduced in patients with nonproliferative DR. These parameters correlate with decreased visual function and with a thinning of macular GCL as well as vascular rarefaction of the inner plexus. Portable pupillometry and electrophysiology may provide useful biomarkers that quantitatively assess and monitor DR based on neurodegenerative dysfunction in a process that parallels progressive vasculopathy.