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Characterization of Phenytoin‐Resistant Kindled Rats, a New Model of Drug‐Resistant Partial Epilepsy: Comparison of Inbred Strains

Summary: Purpose: Previous work from our laboratory showed that amygdala‐kindled Wistar outbred rats can be selected according to the increase of afterdischarge threshold (ADT) after phenytoin application. Animals that consistently do not respond to phenytoin (PHT) with an ADT increase (non‐responders) are the first animal model of pharmacoresistant complex partial seizures. In this study, we determined the ability to respond to PHT in male kindled rats of different inbred strains.