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A comparison of Fc-receptor-bearing lymphocytes in normal individuals and in patients with lymphoproliferative diseases, using EA tests with rabbit and human-sensitizing antibodies.

A comparison between the percentage of rosettes in EA tests, using rabbit and human-sensitizing antibodies and the depletion experiments of rosette-forming lymphocytes, showed that both systems can be used equally well to detect Fc-receptors on mature peripheral blood lymphocytes. The observations made in B-chronic lymphocytic leukaemia and immunocytoma patients suggested, however, that both EA tests determine lymphocytes that differ in Fc-receptors from normal lymphocytes. The possibility that the differences in Fc-receptors are connected with the stage of maturation of lymphocytes is discussed.