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Impact of housing temperature on the adaptation of brown adipose tissue to pregnancy in lean and obese rats

Pregnancy has long been considered a physiological condition in which brown adipose tissue function is reduced. This was considered to represent a mechanism to enable energy conservation by the mother, although whether it is influenced by ambient temperature is unknown. It is now recognised that rodent studies examining brown fat function are conducted at a housing temperature well below thermoneutrality and as such are not immediately relevant to the human situation in which a majority of time is spent at thermoneutrality. The aim of our study was to examine the impact of an obesogenic diet on the mother prior to and during pregnancy and whether the housing temperature modulated the adaptations seen within interscapular brown fat through pregnancy.