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Vasopressin-Evoked ACTH Release in Rats Following Forebrain Removal 1

Summary The effects of lysine vasopressin on plasma concentrations of corticosterone were determined in adult female rats with hypothalamic (HI), pituitary (PI) or anterior pituitary (API) islands. Twenty-four hr after partial brain removal, blood samples were obtained rapidly from the jugular vein for fluorometric determination of “non-stress,”prevasopressin levels of corticosterone. Immediately following sampling, vasopressin (20 mU/100 g of body wt) or saline was injected intravenously; 15 min later rats were decapitated and trunk blood was collected for postvasopressin or -saline corticosterone levels. Whereas HI and PI rats responded to vasopressin with increased plasma corticosterone levels, API and saline-injected HI and PI rats showed no change in corticosterone concentrations. “Nonstress”corticosterone levels were within the physiologic range in HI and PI, but not API rats. These results suggest that the hypothalamus and other forebrain structure are not essential to vasopressin-induced ACTH secretion and that vasopressin acts, at least in part, directly on the pituitary.