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Possible correlation between tumor invasiveness and low serum cholesterol.

The predisposition to solid tumor of individuals with low serum cholesterol may correlate with membrane properties of the emerging neoplastic cells. Evidence is presented to indicate that cholesterol content in the membrane of tumor cells is adjusted with respect to the serum cholesterol. Upon incorporation of cholesterol, tumor cells, which are exemplified here by colon and gastric carcinoma cells, become substantially more immunogenic and therefore more susceptible to clearance by the immune system.