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Magnetic Bead Signal Detection by Self-Field of PHR Sensor

We analyzed the magnetic field dependence of VSF signal, which second harmonic signal was generated by self-field of planner Hall resistance (PHR) sensor. The VSF signal was proportional to the product of sensitivity of PHR sensor and self-field. The magnetic field dependence of bead signal detected by VSF signal showed maximum value at H = 0. The bead signal detected by using the Self-field sensor operated at H = 0 showed linear behavior up to 1/100 bead concentration. Thus, the Self-field sensor can be applied to the external field free biosensor.