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Intracellular accumulation and permeability effects of some weak acids in the isolated frog gastric mucosa.

Acetate, propionate and L-lactate (10 meq/l) stimulated hydrogen ion secretion in the isolated frog (Rana temporaria) gastric mucosa. By use of this stimulatory effect it was shown that these acids accumulate in the gastric mucosal cells when present in the undissociated form on the mucosal (secretory) side. From determinations of the impedance locus diagram and the resistance of the mucosa it was shown that undissociated propionic acid (100 meq/l) increased the ionic permeability of the frog gastric mucosa. A similar effect was obtained with acetic acid. It is probable that intracellular accumulation of undissociated weak acids is the mechanism underlying their permeability increasing effects on the gastric mucosa.