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Methods for Assessing Noninferiority with Censored Data

In this paper we present the existing approaches to the problem of showing noninferiority with randomly right censored data. The main focus is on the choice of the discrepancy measure which is used to define the deviation from the classical null hypothesis, i.e. the noninferiority margin. Most methods are based on certain parametric or semiparametric assumptions. In contrast, a new, completely nonparametric approach is suggested and discussed. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)