{'fraction_non_alphanumeric': 0.030020120724346077, 'fraction_numerical': 0.016659959758551307, 'mean_word_length': 5.336562978072412, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Hydrogen-Bonding Activation in Chiral Organocatalysts Hydrogen-Bonding Activation in Chiral Organocatalysts

In a recent decade, various organocatalysts have been developed to be applicable to a wide range of asymmetric reactions. This review briefly summarizes the hydrogen-bonding activation by chiral noncovalent organocatalysts. First, the differences between hydrogen-bonding catalysts and Brønsted acid catalysts are addressed. Next, the effect of hydrogen-bonding interactions on the transition states is discussed. Finally, the hydrogen-bonding activations by the typical noncovalent organocatalysts, such as thiourea, diol, phosphoric acid, acid-assisted chiral Brønsted acid, and N - triflyl phoshoramide, are shown.


Introduction
The hydrogen bond is the interaction between a hydrogen atom and an electronegative atom, which plays a central role in biological systems. Recently, the utility of hydrogen bond in organic synthesis has been widely investigated, leading to the discovery of novel chiral organocatalysts for the asymmetric transformations [1][2][3].

Noncovalent organocatalysts
In general, noncovalent organocatalysts can be classified into hydrogen-bonding catalysts and Brønsted acid catalysts [20], although these catalysts may rely on other additional noncovalent interactions at the same time. First, the differences between hydrogen-bonding catalysts and Brønsted acid catalysts are addressed. The hydrogen-bonding catalysts play as a hydrogen bond donor toward an electronegative hydrogen bond acceptor (Figure 1). The catalysts forming a hydrogen bond complex are called hydrogen-bonding catalysts. The hydrogen bonds are flexible with regard to bond length and angle. The typical bond length of a hydrogen bond is 1.5 to 2.2 Å. The hydrogen bonds are stronger than a van der Waals interaction but weaker than covalent or ionic bonds. In general, the combination of a neutral electrophile (acceptor) and a weak acid catalyst (donor) leads to hydrogen-bonding catalysis. Therefore, the nucleophilic addition to neutral carbonyl compounds, aldehyde or ketone, takes place via a hydrogen bond complex. In the case of the hydrogen bond-catalyzed reactions, a direct proton transfer from the catalyst (donor) to the electrophile (acceptor) will not occur. In other words, the hydrogen bond-catalyzed nucleophilic addition proceeds without the formation of an ion pair.
Brønsted acid catalysts play as a proton donor toward an electronegative acceptor (Figure 2). In general, the catalysts forming an activated ion pair are called Brønsted acid catalysts. When a catalyst (donor) is a stronger acid, the proton transfer to acceptor occurs to give an ion pair via the hydrogen bond complex. In contrast to hydrogen-bonding catalysts, the combination of basic electrophile (acceptor) and stronger acid catalyst (donor) leads to Brønsted acidcatalyzed reactions. Therefore, the nucleophilic addition to basic imine is often assumed to proceed via the formation of ion pair.
These catalysts might be simply distinguished in the point of view of proton transfer from catalysts. However, it is frequently difficult to make a clear distinction between hydrogenbonding catalysts and Brønsted acid catalysts, because there is the equilibrium between a hydrogen bond complex and an ion pair (Figure 2). Moreover, Brønsted acid-catalyzed reactions can be classified into two types based on where proton transfer occurs to the substrate or to the transition state. Particularly, the Brønsted acid-associated proton transfer in the transition state is closely related to the stabilization of the transition states by hydrogenbonding catalysts.  Thioureas, diols, phosphoric acids, N-oxide, phase-transfer onium salts, etc., are well known as noncovalent organocatalysts [11][12][13][14][15][16][17][18][19]. Thioureas and diols are classified into hydrogenbonding catalysts by means of the mode of activation (Figure 3). In contrast, phosphoric acids are generally classified into Brønsted acid catalysts.

Stabilization of transition states by hydrogen bond
The strength of hydrogen bond becomes larger in the charged interaction than the uncharged interaction (Figure 4) [21][22][23]. The hydrogen bond of a water molecule with a hydroxyl anion (negatively charged acceptor) is almost three times stronger than that with another water molecule (neutral acceptor) in gas phase. The hydrogen bond between a water molecule and a positively charged donor is also strong.  In a hydrogen bond-mediated catalysis, the functions of catalysts are both the activation of substrates and the stabilization of transition states or intermediates. Particularly, the hydrogen bonds effectively stabilize the negative charges in transition states or intermediates [24,25], because the catalysts are bound more strongly to the charged transition states or intermediates than neutral substrates ( Figure 5). Therefore, the study on the transition states or the charged intermediates stabilized by hydrogen-bonding interactions is of importance [26,27], although the catalysts also affect the reaction rates by decreasing the LUMO level of neutral substrates such as carbonyl compounds and imines.

Hydrogen-bonding catalysts
Thioureas and diols are recognized as the typical hydrogen-bonding organocatalysts. This section highlights the hydrogen-bonding activation models and the mechanical investigations using hydrogen-bonding catalysts.

Thiourea derivatives
In 1990, the formation of crystals of diaryl ureas with carbonyl compounds as a hydrogen bond acceptor was reported by Etter's group [28]. Later, this study inspired the impressive development of thiourea catalysts. The chiral bifunctional thiourea catalyst 1 was developed by Takemoto's group (Figure 6) [29,30]. Thiourea catalyst 1 catalyzed the enantioselective Michael addition of 1,3-dicarbonyl compound 2 to nitroolefin 3. The mechanism of this reaction was investigated through density functional theory (DFT) calculations by Pápai's group [31]. Between two transition states A and B, the reaction would proceed predominantly via transition state B due to the lower activation barrier.
Takemoto's group developed the new chiral bifunctional thiourea 5 for catalyzing the enantioselective Petasis-type reaction using organoboronic acids (Figure 7) [32]. In the presence of catalyst 5 and PhOCOCl, the reaction of quinoline 6 with vinyl boronic acid gave the adduct 7 in 96% ee. In this reaction, electrophilic quinoline 6 is activated as a reactive Nphenoxycarbonyl quinolinium salt C. Moreover, the chiral chelating aminoalcohol group of catalyst 5 activates the vinyl boronic acid by coordinating with the boron atom and directs the stereochemical outcome of the reaction as shown in transition state D.   Thiourea catalyst can recognize the in situ generated counteranion by hydrogen bond to give the ion pair. Jacobsen's group studied the thiourea-catalyzed Pictet-Spengler-type cyclization reaction (Figure 8) [33,34]. In the presence of thiourea 8, the cyclization of indolylethyl hydroxylactam 9 gave the cyclic product 10 with good enantioselectivity. In this process, electrophile is activated as an iminium ion [35]. The thiourea catalyst 8 would promote the cyclization of 9 by abstracting a chloride on the in situ-generated intermediate 11. In this proposal mechanism, thiourea 8 works as an anion receptor to form the chiral ion pair E involving the activated N-acyliminium.
The study on pK a values of TADDOL analogues show that the intramolecular hydrogen bond in TADDOL analogues enhances the polarity of the second hydroxyl group and stabilizes the anion resulting from deprotonation [37]. In other words, the formation of the single hydrogenbond complexes such as complex F is favored, because the increase in acidity of the second hydroxyl group on TADDOL is induced by an intramolecular hydrogen bond.   Rawal's group studied the Mukaiyama aldol reaction using TADDOL derivatives (Figure 10) [38]. In the presence of chiral TADDOL 12, the reaction of benzaldehyde 13 with O-silyl-N,Oacetal 16 gave the product 17 in 96% ee. In this study, they succeeded the X-ray analysis of the complex H forming between racemic TADDOL 12 and p-anisaldehyde. The X-ray structure clearly supports the formation of the single hydrogen bond on the oxygen atom of p-anisaldehyde and the intramolecular hydrogen bond in TADDOL 12.

Brønsted acid catalysts
The stronger acids are suitable for catalyzing the nucleophilic addition to basic imines as a Brønsted acid catalyst. This section highlights the activation by Brønsted acid catalyst and the investigations into Brønsted acid-associated proton transfers.

Phosphoric acid derivatives
In general, phosphoric acid derivatives are classified into Brønsted acid catalysts. The chiral BINOL-based phosphoric acid catalysts, independently developed by Akiyama's group and Terada's group, are bearing both Brønsted acidic site and Lewis basic site [39,40]. In some cases, the bifunctional interaction of electrophilic and nucleophilic components plays a crucial role in the transition state of a rate-determining step. Akiyama's group reported the enantioselective Mannich-type reaction using chiral phosphoric acids (Figure 11) [39]. In the presence of phosphoric acid 18, the reaction of aldimine 19 with ketene silyl acetal 20 gave the adduct 21 in 96% ee. The theoretical investigation was performed using an analogous simple phosphoric acid [41]. The computational analysis supports that a double hydrogen-bonding complex I is the favored starting complex over a single hydrogenbonding complex. Moreover, the calculation supports that the proton transfer from phosphoric acid to the nitrogen atom of aldimine 19 occurs to give the iminium complex J as a stable ion pair.
The reductions of imines with Hantzsch ester 23 have been widely investigated by the use of various chiral phosphoric acids. MacMillan's group reported that the phosphoric acid 22catalyzed reduction of imine, generated from ketone 24 and aniline 25, proceeded with a good enantioselectivity [42]. In his paper, the single bonding complex between imine and Brønsted acid catalyst 22 was proposed. More recently, Goodman's group performed the DFT calculation study, which indicates that the ternary complex between imine, catalyst 22, and Hantzsch ester 23 is important to stereochemical course [43]. The Z-imine transition state K is on the lowest energy route to the product (Figure 12).

Brønsted acid-assisted chiral Brønsted acid
Ishihara's group developed Brønsted acid-assisted chiral Brønsted acid catalyst 27 (Figure 13) [44]. In the presence of catalyst 22, Mannich-type reaction of aldimine 28 with ketene silyl acetal 29 enantioselectively proceeded to give the adduct 30 in 77% ee. The X-ray analysis of catalyst 27 indicates the acidity of bis(triflyl)methyl proton of 27 increases by intramolec-ular hydrogen bond between phenolic hydroxy group and oxygen atom of triflyl group, which is 2.305 Å. Therefore, the activation of aldimine 28 by the acidic bis(triflyl)methyl proton of 27 should be important.

N-triflyl phoshoramide
Yamamoto's group studied the Diels-Alder reaction using chiral N-triflyl phoshoramides ( Figure 14) [45]. N-triflyl phoshoramides are strong Brønsted acids due to a strong electronwithdrawing triflyl group. In the presence of N-triflyl phoshoramide 31, the reaction of ethyl vinyl ketone 32 with diene 33 effectively proceeded to give the cyclic adduct 34 in 92% ee, accompanied by the isomeric adduct 35. The bulky 1,3,5-(i-Pr) 3 C 6 H 2 groups on catalyst 31 are essential to achieve the reaction with good chemical efficiencies.

Concluding remarks
The utilization of organocatalysts in organic synthesis has become a subject of recent research. Particularly, chiral hydrogen-bonding catalysts and chiral Brønsted acid catalysts have developed as the highly efficient noncovalent organocatalysts for a broad spectrum of asymmetric transformations. One of the most important features of noncovalent organocatalysts is that we can use the hydrogen bond for the stabilization of transition states or intermediates as well as the activation of C=O bond in carbonyl compounds or C=N bond in imines.
Because the use of organocatalysts has many advantages in organic synthesis form both economical and environmental points of view, the research into organocatalysts continues to blossom and grow.