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An Appraisal of the Efficacy of the Antiviral R 61837 in Rhinovirus Infections in Human Volunteers

The efficacy of the antiviral R 61837 in experimental colds in three previously reported volunteer trials and one new trial is reviewed here. It was dissolved in a new vehicle, hydroxy-β-cyclodextrin, and used as a nasal spray. A substantial reduction in illness occurred when given prophylactically and during the incubation period but not when used therapeutically.