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Importance of C16 ceramide accumulation during apoptosis in prostate cancer cells

Aim:  Adenocarcinoma of the prostate is one of the most frequently diagnosed non‐cutaneous cancers and the second leading cause of cancer‐related deaths among men in the United States. To fully understand the role of ceramide during apoptosis induced by androgen ablation, we modified the levels of intracellular ceramide by pharmacological agents as well as through serum deprivation in androgen‐dependent and independent cell lines.