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Baroreflex response to orthostatic challenge: Effect of aging

Aging causes changes in cardiovascular control. The aim of the study was to analyze the effects of age on baroreflex sensitivity of healthy individuals of different ages, through cross-spectral analysis. One hundred and ten individuals divided into 5 age groups were evaluated. Heart period (HP) and systolic blood pressure (SBP) were derived from ECG and blood pressure signals recorded simultaneously for 15 minutes in the supine and orthostatic position. The gain of the transfer function from SBP to HP was taken as an index of baroreflex sensitivity (BRSgain) and computed in low (LF) and high frequency (HF). In both positions and in both bands, BRSgain fell with age, thus suggesting a decrease magnitude of the HP response to SAP changes with age.