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Patient-reported outcomes following preoperative chemoradiotherapy for rectal cancer: A prospective multicenter observational study

4099 Background: Little evidence is available on patient reported outcomes (PROs) following preoperative chemoradiotherapy (CRT) for rectal cancer. Methods: 151 patients with mid-low rectal cancer were enrolled in this study. PROs were evaluated with methodologically sound robust measures. Quality of life was measured with the EORTC QLQ-C30 and its colorectal cancer module (QLQ-CR38). Psychological aspects, fecal incontinence and functional outcomes were measured respectively with the Psychological Well-Being Index (PGWBI) and the Fecal Incontinence Score (FIS) questionnaires. All self-reported questionnaires were completed before CRT (baseline, t0), 3 weeks after the completion of CRT (t1), and then at 6 (t2) and 12 months (t3) after surgery. Socio-demographic and clinical data were also collected. Comparisons were made by repeated measures analysis of variance for each PRO domain. Analysis was planned a priori on most relevant outcomes. A p-value <.01 was considered statistically significant. Results: C...