{'fraction_non_alphanumeric': 0.02545968882602546, 'fraction_numerical': 0.009900990099009901, 'mean_word_length': 5.616822429906542, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Suppression of Skeletal Muscle Interleukin‐6 Alters Circulatory Cytokine and Leukocyte Trafficking in Septic Female Mice

Interleukin‐6 (IL‐6) is one of the major cytokines released by skeletal muscle in response to blood pathogens. Nevertheless, the contribution of IL‐6 secreted by skeletal muscle (skmIL‐6) to innate immunity is not well understood. We utilized a floxed IL‐6 knockout mouse crossed with a skeletal muscle inducible CRE mouse to evaluate the contribution of skeletal muscle IL‐6 secretion to the circulatory cytokine profile and leukocyte trafficking in septic mice. Sepsis was induced using intraperitoneal injection of a standardized dose of cecal slurry (CS) collected from donor mice.