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[Optimization of extraction procedure of tongmai granules by orthogonal design with pharmacodynamic index].

OBJECTIVE
To optimize the extraction technology for anti-myocardial ischemia active component group in tongmai granules.


METHOD
The extracting conditions were optimized by using orthogonal experiment and pharmacodynamic index. Employing puerarin, ferulic acid, tanshinone IIA, and salvianolic acid B as indexes, the effects of ethanol concentration, solvent volume, extraction times and extraction time on the extracting process were investigated.


RESULT
The optimum extraction process was adding 8 times amount of 70% alcohol, refluxing and extracting for 3 times, 1.5 h each time.


CONCLUSION
This extraction process shows good stability and is available for extracting anti-myocardial ischemia component group in tongmnai granules.