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Dexamethasone as an Antiemetic in Children Receiving cis-Platinum

Nine children with malignant neural crest tumors and two with hepatoblastoma receiving cis-platinum were randomized to receive intravenous dexamethasone or no other antiemetic drug. Patients were given cis-platinum 45 mg/m2 of body surface area/day for 2 days, every 2 weeks and dexamethasone was given on every other cis-platinum course at a dose of 1 mg/m2 of body surface area, every 4 h for a total of 10 doses. When these 11 patients were used as their own control, the number of vomiting episodes was significantly less during the cis-platinum courses with dexamethasone. Dexamethasone appears to be an effective and safe antiemetic in children receiving cis-platinum.