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Pathogenesis and managenent of pain in chronic pancreatitis.

INTRODUCTION Of the three cardinal manifestations of chronic pancreatitis-pain, diabetes mel litus and steatorrhea, it is pain that brings the patient to the physician and is the most difficult to manage. The intractabale pain that is quite debilitating disrupts lifestyle and leads to functional incapacity, drug and alcohol dependency, and a drug-see king behavior that occasionally might push the desperate patient to suicidal ten d ency. Painless CP is an exception that has been observed in nearly 5% to 10% of patients with all forms of chronic pancreatitis. Lack of pain is also a feature of the late onset idiopathic CP.