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Abstract 14938: Impact of Cerebrovascular Comorbidity on Prognosis in Patients Undergoing Percutaneous Coronary Intervention: 1-year Data From Japanese Multi-center Registry


 Background:
 Cardiovascular and cerebrovascular diseases are considered the principal cause of morbidity and mortality worldwide; the effect of stroke-induced cardiac manifestations is well recognized; however, not enough clinical data has been found about the impact of stroke with underlying cardiac disease. This study’s objective is to assess the impact of stroke on the prognosis of patients with underlying IHD, who underwent PCI treatment.
 
 
 Methods and Results:
 This was a multicenter, 1-year observational study in patients undergoing PCI in one of the 17 participating centers across japan. 18,495 patients were registered on the PCI list; 2481 patients had a prior stroke experience, whereas 15979 were stroke-free. Our study revealed that stroke patients were significantly older (mean age73.5±9.6, 69.7(±11.5) respectively), and suffered from more comorbidities (diabetes, hypertension, and chronic kidney disease, p<0.0001). During the one-year period, subjects with stroke showed higher incidence of clinical events compared to those without stroke; to illustrate, all-cause death accounted for 6.2% in patients with stroke, in contrast to only 2.8% in stroke-free patients (p<0.0001),cardiac death amounted for 2.2% and 1.2% respectively (P<0.0001), recurrent stroke for 3.1% and 1.2% (P<0.0001), non-cardiac death for 3.6% and 1.54% (P<0.0001),and finally, hemorrhagic complications with 2.6% and 1.3% (p<0.0001).Kaplan-Meier analysis revealed that stroke patients had a higher probability of all-cause mortality, cardiac death, and recurrent stroke (log-rank p<0.0001). Cox hazard analysis also revealed that the presence of stroke is a significant indicator in determining the outcome of cardiac death (HR=1.457, 95%CI=1.036–2.051, p=0.031), thus proving it to be a crucial predictor on cardiac prognosis.
 
 
 Conclusion:
 History of prior stroke was common in PCI patients, and independently associated with a higher rate of subsequent cardiovascular and cerebrovascular events recurrence, thus highlighting urgent need for comprehensive prevention of cardiac and cerebrovascular diseases
