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Enhancement of Antimicrobial Activity of Neuropeptide Y by N-Terminal Truncation

ABSTRACT The activity of neuropeptide Y (NPY) against Candida albicans, which was revealed to be fungicidal, was enhanced significantly by the truncation of amino acid residues at the N terminus. The most active peptides (MICs, approximately 1 μM) were about 10-fold more potent than the intact NPY (MIC, approximately 10 μM). The enhancement was weakened by the replacement of the N terminus by negatively charged residues and/or acylation of the α-amino group. These results suggest that only the α-helical region of NPY is necessary for the antimicrobial activity and that the net charge of the peptide is important for the activity.