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A comparative study of carrier detection in haemophilia A by linear discriminant function

Summary. Blood samples collected from 37 definite carriers, 31 normal women and 64 possible carriers were examined for factor VIII‐related activities. Five variables: factor VIII coagulant activity (VIII:C) (X1), factor VIII‐related antigen (VIIIR:Ag) (X2), ristocetin co‐factor (VIIIR:RC) (X3), ratio of VIIIR: Ag to VIII:C (A/C) (X4) and ratio of VIIIR: RC to VIII:C (R/C) (X5), and 28 combinations of one to five variables were used to derive 28 linear discriminant functions. The calculation of discriminant function coefficient, individual discriminant score and cut‐off point, and the identification of normals or carriers were processed by the computer package of a biomedical computer program used at University of California at Los Angeles.