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Patients with ovarian cancer have elevated 51Cr-EDTA plasma clearance early post-operatively

Plasma clearance of 51Cr-EDTA (ClpEDTA) is widely used to determine glomerular filtration rate prior to carboplatin based chemotherapy. We have observed that many patients with ovarian cancer have elevated ClpEDTA in the early post-operative phase compared to later phases. The purpose of this study was to examine whether this observation reflects a systematic difference. We retrospectively analysed data from 53 patients who had undergone surgery for ovarian cancer. Twenty-six patients had ClpEDTA measured early after the operation (mean, 8 days (range, 3-16 days)) (early group), and 27 patients had ClpEDTA measured late post-operatively (mean, 32 days (range, 19-48 days)) (late group). ClpEDTA values was measured before the first, third and fifth course of chemotherapy. Additionally, age, height, weight, cancer stage, ascites and tumour histology were noted. Mean ClpEDTA in the early group was significantly higher than in the late group (104±4.4 vs 89±3.5 ml·min−1 per 1.73 m2; P = 0.005). ClpEDTA declined significantly in the early group from the first measurement after the operation until measurement before the third course of chemotherapy but remained constant in the late group. ClpEDTA was not correlated to ascites, cancer stage or tumour histology. It is concluded that patients with ovarian cancer have significantly higher ClpEDTA in the early post-operative phase than similar patients with ClpEDTA measured late post-operatively.