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Extracellular matrix fibronectin initiates endothelium‐dependent arteriolar dilatation via the heparin‐binding, matricryptic RWRPK sequence of the first type III repeat of fibrillar fibronectin

The local arteriolar dilatation produced by contraction of skeletal muscle is dependent upon multiple signalling mechanisms. In addition to the many metabolic signals that mediate this vasodilatation, we show here that the extracellular matrix protein fibronectin also contributes to the response. This vasodilatory signal requires the heparin‐binding matricryptic RWRPK sequence in the first type III repeat of fibrillar fibronectin. The fibronectin‐dependent component of the integrated muscle contraction‐dependent arteriolar vasodilatation is coupled through an endothelial cell‐dependent signalling pathway.