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A new antigen identified by the monoclonal antibody UCHB1 delivers a costimulatory signal to a subset of human B cells

A novel anti‐B cell monoclonal antibody UCHB1 is described which detects an antigen present on a selected subpopulation of both normal and leukemic B cells. Approximately 20% of normal tonsil and peripheral blood (PB) B cells are UCHB 1+ and the majority of B cells from all cases of prolymphocytic leukemia (PLL) tested, together with a low, variable percentage of PB B cells from non‐Hodgkin's lymphoma patients with centroblastic centrocytic leukemia also express this antigen.