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Toxicological and pharmacological actions of methacrylate monomers. 3. Effects on respiratory and cardiovascular functions of anesthetized dogs.

Methacrylic acid and 12 methacrylate esters were evaluated for their effects upon blood pressure, heart rate, electrocardiogram, and respiration in anesthetized dogs following intravenous administration. All of these compounds increased respiratory rate, decreased heart rate, and produced electrocardio-graphic changes. The compounds could be divided into three types according to their effects on blood pressure: I, those producing a biphasic response, i.e., an abrupt fall followed by a secondary rise; II, those producing only a hypotensive effect; and III, one producing only a hypertensive response. The compounds comprising Type I were methacrylic acid; methyl, ethyl, n-propyl, n-butyl, isobutyl, and hydroxyethyl methacrylates; and 1,3-butylene dimethacrylate. Type II compounds were 2-ethylhexyl, isodecyl, lauryl, and tert-butylaminoethyl methacrylates. Dimethylaminoethyl methacrylate produced the Type III response.