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Passive vectoring of a colloidal carrier system for sodium stibogluconate: preparation, characterization and performance evaluation.

The intracellular residence of the Leishmania parasite in the cells of the reticuloendothelial system--predominantly the liver and spleen--prompted the development of a polymeric, particulate, colloidal carrier system for the antileishmanial drug sodium stibogluconate. The system was pharmaceutically characterized for shape, size, structural integrity, electrokinetic properties and in vitro drug release. The relationship between such physical parameters as size, electrophoretic mobility and surface charge and the effectiveness of the system is discussed. Subsequent in vivo studies in rats revealed that the carrier system successfully vectored the drug to the site of infection.