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Stability-Indicating HPTLC Analysis of Flurbiprofen in Pharmaceutical Dosage Forms

A sensitive, selective, precise, and stability-indicating high-performance thin-layer chromatographic (HPTLC) method has been established for densitometric analysis of flurbiprofen in pharmaceutical tablets. Chloroform-acetone-xylene 5.0:2.0:1.0 (v/v) was used as mobile phase. Regression analysis of the calibration data revealed a good linear relationship between peak-area response and amount of flurbiprofen in the range 50-600 ng per band (r2 = 0.9993 ± 0.0004). The limits of detection (LOD) and quantification (LOQ) were 10 and 32 ng per band, respectively. Flurbiprofen was subjected to different stress conditions. An Arrhenius plot was constructed for degradation under acidic conditions and the activation energy was calculated.