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Effect of UV Light on RNA-Directed DNA Polymerase Activity of Murine Oncornaviruses

The UV inactivation of RNA-directed DNA polymerase activity of Rauscher leukemia virus was shown to be due to damage to the protein. The UV dose resulting in 37% survival of viral polymerase activity at 254 nm was 2.4 × 104 to 3.1 × 104 ergs/mm2. The inactivation rate of p30, a major internal viral protein, was much slower.