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Evaluation of the combination of tryptophan and ECT in the treatment of depression

A double‐blind evaluation of the antidepressant efficacy of treatment with a combination of orally administered L‐tryptophan (L‐TP) and electroconvulsive therapy (ECT) was made in patients suffering from endogenous depression. The patients were randomly assigned to two groups, one treated with L‐TP (6 g daily) and unilateral ECT, the other with placebo and unilateral ECT. L‐TP treatment was initiated at least 1 day before the first ECT and terminated 4 days after the last ECT.