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Cryptococcal meningitis successfully treated with voriconazole and low‐dose amphotericin B

A 79‐year‐old patient with diabetes mellitus was diagnosed with cryptococcal meningitis based on detection of Cryptococcus neoformans from cerebrospinal fluid culture. After administration of liposomal amphotericin B, the patient promptly developed acute renal failure as a side‐effect. We therefore switched treatment to voriconazole with low‐dose liposomal amphotericin B. Cerebrospinal fluid cultures and antigen titer for Cryptococcus became negative 266 days after initiating voriconazole. The present case suggests that voriconazole might be useful as induction therapy to reduce the risk of renal insufficiency and achieve successful outcomes.