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Neuroendocrinological approach for examining the mechanisms of action of Toki‐Shakuyaku‐San (TJ‐23) on the activity of tyrosine hydroxylase in the brain

Administration of the Kampo medicine, TJ‐23, to ovariectomized rats resulted in decreased tyrosis hydroxylase (TH) activity in the dorsal hippocampus but an increased activity in the ventral tegmental area. A decrease of TH activity in the hypothalamus was not statistically significant. The effect of TJ‐23 was compared to oestrogen in a similar group of rats and it was concluded that the standard drug and TJ‐23 induced similar effects.