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Relation of Vitamin D Deficiency with Breast Cancer Staging in Patients from INMOL Cancer Hospital

Introduction: Vitamin D deficiency can be critical and is reported to be as one of the factors for development and progression of breast carcinoma.

Aims & Objectives: To measure and compare 25(OH)D (calcidiol) levels in healthy females and in breast carcinoma patients in four different stages. Place and

duration of study: This cross sectional study and research was conducted in Shaikh Zayed Medical Complex in the Department of Biochemistry and Chemical Pathology from Jan 2018 to Jan 2019. The patients were selected from INMOL Cancer Hospital, Lahore.

Material & Methods: The study was carried out on 39 healthy females (controls) and 156 newly diagnosed cases of carcinoma breast from stage I to IV, 39 patients of each stage. 25(OH)D was determined in blood samples of patients by ADVIA Centaur (XP) immunoassay system.

Results: In this study the mean 25(OH)D level of healthy females with mean age of 41.7 ± 15.8 years, was 25.1 ± 5.5ng/ml. 25(OH) D level of breast cancer patients was found to be decreasing with stage progression. For the stage I the average 25(OH)D level was 12.31ng/ml, stage II was 9 ng/ml, stage III was 8.3 ng/ml and stage IV was 8.4 ng/ml.

Conclusion: It was found that healthy group of females had higher values of serum vitamin D levels as compared to breast carcinoma patients. Low concentration of serum vitamin D may contribute to the progression of stage of breast carcinoma.