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In-vitro cell migration enhancing and pro-angiogenic active secondary metabolites from Jeffreycia zeylanica (L.) H. Rob., S.C. Keeley & Skvarla (Asteraceae).

Jeffreycia zeylanica (L.) H. Rob., S. C. Keeley & Skvarla is used for the treatment of wounds in indigenous medicine practiced in Sri Lanka. The scratch wound assay (SWA) guided fractionation of hexanes extract of J. zeylanica led to the isolation of ethuliacoumarin (1), stigmasterol (2), β-amyrin (3) and lupeol (4) and a non-resolved triterpene alcohol mixture HF5D1, all of which showed enhanced cell migration. The mixture HF5D1 contained glut-5-en-3β-ol (5) and friedelin-3β-ol (6). The identities of compounds 1-6 were established by the analysis of spectroscopic data and comparison of them with those reported. The compounds 1-4 and the non-resolved triterpene alcohol mixture, HF5D1 also exhibited significant proangiogenic response in chorioallantoic membrane (CAM) assay in addition to the enhanced cell migration. This is the first report of the occurrence of the compounds 1, 2, 4 and 5 in this plant.