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Article of Significant Interest Selected from This Issue by the Editors

The relationship between osteoporosis and obesity remains an important clinical question. Osteoblasts and adipocytes share a common mesenchymal precursor, but the transcriptional events leading to lineage commitment in bone versus fat cell fate decisions are not entirely understood. Addison et al. (p. 3076 –3085) report that Zfp521 favors the osteogenic versus adipogenic potential of mesenchymal precursors during bone morphogenic protein (BMP)-induced differentiation. Zfp521 occupies the promoter and intronic enhancer of Zfp423, a key driver of adipogenesis, leading to epigenetic silencing of Zfp423 expression. Furthermore, Zfp521 synergizes with Smads to mediate the proosteogenic effects of BMP. Loss of Zfp521 thus predisposes the fate of mesenchymal precursors towards adipogenesis.