{'fraction_non_alphanumeric': 0.039761431411530816, 'fraction_numerical': 0.014910536779324055, 'mean_word_length': 5.177914110429448, 'pattern_counts': {'":': 0, '<': 4, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Improved diastolic LV filling after acute application of ajmaline in patients with coronary artery disease and normal systolic LV function

To determine whether ajmaline (A) can be safely applied in coronary artery disease (CAD), changes of left ventricular (LV) function after acute ajmaline application were analyzed by pulsed Doppler echocardiography in 10 CAD patients. LV pressures in systole and end‐diastole and LVEF remained normal and comparable. Doppler normalized peak filling rate (p < 0.02), peak early/atrial filling velocity (E/A) ratio (p < 0.01) and E‐deceleration (p<0.05) increased. The increase in E/A and in E‐deceleration relative to base values was directly correlated (p < 0.001). PEP increased, LVET remained unchanged. LV diastolic filling is improved after acute application of ajmaline in patients with CAD and normal systolic function; its application may be advised not only for therapy of arrhythmia but also to improve left ventricular diastolic mechanics in these patients.