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Cell culture media: NMR approaches to evaluating quality and nutrient consumption.

Cell culture media is widely used to provide nutrients for cell growth in research, diagnostic and manufacturing applications. Its use is increasing as a result of the growing focus on the development and production of biologics and biosimilars in the pharmaceutical industry. Typical cell culture media contain a mixture of defined nutrients that are expected to produce the desired product. Precise control of the nutrient composition over time is critical for optimal cell culture performance and the quality of the resulting product. The nutrients are often small molecule components that may be monitored using NMR utilizing a metabolomics approach. NMR spectroscopy was used for monitoring the nutrient mixtures in this study to take advantage of it’s unique characteristics of being quantitative, non-destructive, and requiring only minimal sample preparation.1,2