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Circadian Rhythms in Cardiovascular Disease

Circadian (circa about, dies a day) rhythms relate to the rhythmic repetition of certain phenomena in living organisms at about the same time each day. In recent years the existence of circadian rhythms in the time of onset of acute cardiovascular events has been described in several epidemiological studies. These observations are important because they may help to clarify the involvement of several pathological processes in the onset of acute cardiovascular events. The recognition of the role of various factors in this process may result in the development of preventative strategies and/or advances in therapeutic management. This article reviews the epidemiological evidence for circadian rhythms in cardiovascular disease and the underlying mechanisms which may be responsible for these.