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Decreased calcium mobilisation and the lack of secretion in equine sweat gland cells

Sweat secretion helps maintain skin surface ecosystems and allows humans and the Equidae to thermoregulate. A key component in sweat secretion is an increase in intracellular Ca2+ ([Ca2+])i from internal and external sources. Regulation of Ca2+ entry across the plasma membrane is initiated by emptying of the intracellular Ca2+stores and through a process known as store–operated Ca2+ entry (SOCE) via STIM and Orai proteins.