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Structure factor model-based approach for analyzing two-dimensional impedance map and studying scattering from polydisperse dense media

A two-dimensional (2D) computational model of acoustic impedance (Z) constructed from histological tissue images, termed 2D Z map (2DZM), was recently proposed to obtain quantitative information about tissue scattering (Luchies & Oelze 2016). However, this 2DZM approach was limited to isotropic and sparse media. The present study investigates the 2D structure factor model (SFM) in 2DZM approaches to take into account coherent scattering occurring in dense media. Studies of 2DZMs obtained from simulations of quantitative acoustic microscopy (QAM) experiments were performed to evaluate the ability of 2D SFM-based approach to accurately quantify scattering.