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Imaging in the single-scattering, few-scattering, and light diffusion regimes with low-coherent light

Optical coherence tomography (OCT) affords diffraction- limited resolution to a depth of several hundred micrometers is tissue while diffuse optical tomography (DOT) offers few millimeter resolution through several centimeters of tissue. OCT typically works with singly scattered light while DOT uses diffuse light. To the best of our knowledge, no imaging technique uses light that has scattered multiple times, but is not yet diffuse. We believe that such a technique can offer hundred micron resolution for image depths up to a centimeter in tissue, thus filling the void between OCT and DOT. We demonstrate how OCT and DOT can be extended to the few scattering regime. We present experimental measurements of the broadening of the OCT point spread function as the imaging volume is moved to greater optical depth sin a highly scattering medium. Comparisons to Monte Carlo simulations are made in our other manuscript in this proceedings.