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Articles of Significant Interest Selected from This Issue by the Editors

Oenococcus oeni is a wine-associated lactic acid bacterium mostly responsible for malolactic fermentation of wine. Due to the obvious lack of genetic tools for this bacterium, gene disruption is not presently practicable, causing difficulty in understanding the adaptability of O. oeni in hostile environments like wine. Darsonval et al. (p. 18 –26) describe a new genetic tool to develop an innovative antisense RNA approach for modulating gene expression. Focusing on expression of the hsp18 gene, encoding the small heat stress protein Lo18, this work demonstrates the tool’s effectiveness and the in vivo involvement of Lo18 in the thermotolerance and acid tolerance of O. oeni.