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General practitioners’ attitudes towards early diagnosis of dementia: a cross-sectional survey

Background Dementia is often underdiagnosed in general practice, which may be based on general practitioners’ (GPs’) knowledge and emotional factors as well as external problems. This study aimed to describe GPs’ attitudes toward early diagnosis of dementia. Methods Cross-sectional postal survey in Switzerland in 2017. Members of the Swiss Association of General Practitioners (N = 4460) were asked to participate in the survey. The questionnaire assessed attitudes, enablers and barriers to early dementia diagnosis and post-diagnostic intervention strategies. Exploratory factor analysis and linear regression were used. Results The survey response rate was 21%. 85% of GPs agreed with enablers of early dementia recognition (e.g. “Plan for the future, organize support and care”, “Minimize the strain and insecurity of patients and their informal family caregivers”). On the other hand, 15% of respondents perceived barriers towards early dementia recognition (e.g. “Time constraints in carrying out the necessary procedures to diagnose dementia”). GPs who were more likely to agree with barriers would less often counsel family members (β = − 0.05, 95% CI = − 0.09 - -0.02) or test fitness to drive (β = − 0.05, 95% CI = − 0.09 - -0.02), and more often choose a watchful waiting strategy (β = 0.05, 95% CI = 0.02–0.09). Conclusions The attitude of the majority of GPs is not characterized by diagnostic and therapeutic nihilism. However, negative attitudes were associated with sub-optimal management after the diagnosis. Thus, health systems are required to critically examine the use of available resources allowing GPs to look after patients and their relatives in a holistic way. Electronic supplementary material The online version of this article (10.1186/s12875-019-0956-1) contains supplementary material, which is available to authorized users.


Background
A central aim of strategies on dementia is to enable high quality, low-threshold and continuing provision of health-care services for individuals with dementia [1][2][3]. The diagnosis of dementia is an important step for access to care and support, and the prevention of stress or crises for carers; and it is advantageous for individuals and their families in how they cope with the prognosis [4].
General practitioners (GPs) have regular contact with the majority of the elderly population and therefore play a pivotal role in the assessment of incipient cognitive decline and dementia. Nevertheless, a high rate of underdiagnosis of dementia has been reported in primary care [3,[5][6][7][8]. A systematic literature review found important barriers to early diagnosis of dementia in primary care, including lack of support, time and financial constraints, stigma, diagnostic uncertainty, and GP's fear that disclosure could damage the doctor-patient relationship [9]. Evidence also revealed other important themes such as delayed presentation and therapeutic nihilism [9].
In contrast, the benefits of early recognition of dementia include receiving early access to treatment, appropriate information, advice and support to improve the quality of life of patients, caregivers, and relatives [10][11][12]. In particular, patients can be involved in decision-making processes and have the possibility of independent planning for the future (e.g. living will or advanced care plan) [4]. In addition, timely measures can be taken in order to prevent endangering themselves or others (e.g. driving a car, or professional responsibility at work). Early GP interventions have been shown to help caregivers in anticipating and accepting the future care role and transitions, with the increased possibility that caregivers can still involve the patient in the decision making process [12]. Further, dementia care management has been shown to decrease the burden on and associated health impairments of caregivers [13]. Further, people with dementia and their caregivers have recently highlighted the need for GPs to engage in counselling and in signposting of local services [14].
To inform efforts to increase the quality of health-care services for individuals with dementia it is essential to better understand the drivers of GPs' attitudes towards dementia, including underlying enablers and barriers in the early recognition of dementia across GP and practice characteristics. This may help to identify whether there is a need for tailored education, training or support. Prior studies investigating GPs' attitudes towards early dementia recognition have found an association with age [15], location of practice [16], gender, and professional experience [17]. Further, GPs' decisions to diagnose dementia have been shown to be influenced by their own beliefs about dementia and the efficacy of treatment [18]. However, these studies have tended to focus on a limited set of attitudes [15,19,20] and have rarely examined the association with GPs' current management of dementia patients [21,22].
In Switzerland, the primary care system is mostly based on fee for service. Even if a GP provides a treatment the patient does not actually need, the GP will still be compensated for it. In retrospect, it is practically impossible to prove that a medical service would, in fact, have been unnecessary. Currently there are no binding guidelines relating to medical treatment that help determine which measures should be deemed necessary and expedient for a certain medical condition and which ones can no longer be considered appropriate. Consequently, this means that there are no formal restrictions on the comprehensive diagnosis and treatment of people with suspected dementia.
The main question of this study was whether certain attitudes as well as enablers and barriers to dementia recognition are reflected in the way GPs manage patients with confirmed or suspected dementia, i.e. their professional approach. The latter is exemplified by the average stage of dementia at the point at which a patient is first diagnosed, as well as the GP's choice of different treatment options when assessing a case vignette of mild dementia. Building on the existing literature, we sought to investigate a broad range of attitudes as well as enablers and barriers to early recognition of dementia, using factor analysis to group them into underlying themes. We then explored the interrelation between attitude themes towards early recognition of dementia and professional approach to the disease and its management.

Methods
The project was conducted by the Centre for Primary Health Care at the University of Basel, and was supported by all academic institutes of general practice at Swiss universities.
The present cross-sectional postal survey was designed to test attitudes to the early recognition of dementia and dementia care [15,16,19,[23][24][25] as well as barriers and enablers [9,[26][27][28][29]. GP's were also asked to indicate at which stage most of their patients received the first diagnosis. The stage of dementia at the point of first diagnosis [3] comprised MCI, mild, moderate and severe dementia. The definitions of the stages were explained in the questionnaire and were based on a classification from a national consensus [30] (see Supplementary Information S 1).. The attitude items were based on two previous questionnaires about GPs' attitudes on dementia [15,19] and comprised statements such as "The early recognition of dementia usually serves the welfare of the patient/patient's relative" or "Managing dementia is more often frustrating than rewarding". Barriers and enablers of early dementia were also based on previous findings from literature [9,[24][25][26][27] and contained statements such as "With a timely diagnosis GPs/patients may take actions to improve disease outcome, delay institutionalization, reduce dangerous and difficult situations etc.). For all questionnaire items see Supplementary Information S 3. The questionnaire further assessed the management approach after diagnosis of a hypothetical case of mild dementia. The vignette comprised the question "What measures would you take if a patient was diagnosed with an early stage Alzheimer's disease? (MMSE of 24 and the need of some assistance in activities of daily living)". The items of these post-diagnostic intervention strategies have been presented in detail elsewhere [31]. All items were assessed using a five-point Likert scale, except the stage of dementia at the point of first diagnosis (MCI, mild, moderate or late stage), and the demographic characteristics of the GP. Content validity was pre-tested among a small group (n = 7) of GPs for readability and acceptability. The initial questionnaire was developed in German and two independent translations in French and Italian were made by professional translators. The meaning and the appropriateness of the translated items were assessed by the study team.
The survey was sent by mail to all GP members of the Swiss Association of General Practitioners and Paediatricians (n = 4460) in August 2017. A reminder was sent to all members by e-mail 1 month later. Responses were collected anonymously.
We used descriptive statistics to summarize physician and practice characteristics. To identify underlying themes among GP attitudes for or against early dementia recognition, we performed exploratory factor analysis (EFA) with n = 2 factors [32] (see Supplementary Information S 6, S 7, S 8). A summary score was created for each factor, ranging from 1 to 5 (see S 6). We determined the association between the summary scores and the following predictors; respondents' demographic and practice characteristics, average stage of dementia diagnosis, and management approach, using univariable and multivariable linear regression models (for each summary score separately). Multivariable models were adjusted for age, workload, practice location and the estimate of the percentage of patients over the age of 70. Missing data were not imputed and regression analyses were performed on complete cases. P values of < 0.05 were considered statistically significant. All data analyses were conducted using R version 3.4.3 [33].

Sample
Of the 4460 GPs initially contacted, 306 were either no longer practising as a GP, or the letter was undeliverable; this left a sample of 4154 GPs. A total of 882 (21%) returned the questionnaire. The respondent GPs were 55.8 (SD = 8.86) years old on average, and 70% were male (see Additional file 1: Table S2 for summary statistics of demographic characteristics). The responding GPs did not differ from the contacted GPs in terms of gender (χ 2 = 0.25, df = 1, p-value = 0.617). However, responding GPs did differ from the contacted GPs in terms of language region (χ 2 = 6.1, df = 2, p = 0.046) as there were more German-speaking (78%) respondents compared to the contacted sample (75%). Further, on average the respondents were 1 year younger than the whole contacted sample (55.8 vs. 56.7 years, t = − 2.77, p = 0.006).
General attitude towards early recognition of dementia and care for patients with dementia  Table S3 show a general attitude that is positive, characterized by the feeling that early diagnosis was beneficial. In particular, more than half of responding GPs perceived a benefit for the welfare of the patient's relatives (61% agreed/strongly agreed), while half of them saw a benefit to the patients themselves, and did not think the management of dementia was frustrating. Negative or nihilistic attitudes were less prevalent; 18% stated the management of dementia to be frustrating, 33% agreed that providing a patient with a dementia diagnosis is providing a diagnosis that is not clinically actionable, and 45% did not feel that current treatment options (e.g. anti-dementia drugs) had a positive effect on the course of the disease. The majority of GPs agreed with most enablers to timely diagnosis (except "With a timely diagnosis GPs/patients may take action to improve disease outcome") and disagreed with most barriers (except "Inadequate financial remuneration hinders diagnosis"). Most GPs (62.5%) reported an average stage of "mild dementia" at the point of first Fig. 1 Ranked attitudes towards early dementia diagnosis. Attitudes were ranked according to their agreement (strongly agree and agree) diagnosis, 31.2% of respondents reported average stage of "mild cognitive impairment" at the point of first diagnosis, and 6.2% of GPs reported "moderate stage of dementia" at the point of diagnosis. The frequencies of Likert Scale answers of post-diagnostic intervention strategies are described in Additional file 1: Table S4.

Exploratory factor analysis
The EFA yielded an 18-item scale with 2 factors explaining 34% of the variance (see Table 1 and Additional file  1: Tables S5, S6, S7 and S8 for more details on factor analysis). The first factor comprised GPs' enablers to providing early dementia diagnosis, which was supported Most variables of the first factor loaded substantially onto only one factor. From the variables loading positively onto the second factor, 3 variables also loaded negatively onto the first factor. Further, there were two items that did not fit well in the solution ("Managing dementia is more often frustrating than rewarding" and "Providing a patient with a dementia diagnosis is providing a diagnosis that is not clinically actionable"). Mean scores represent the mean agreement in responses for each scale, with 1 indicating a low agreement and 5 the highest possible agreement. Agreement is represented by the percentage of mean scores higher than 3 across responding GPs by 85% of GPs. The second factor comprised barriers to providing early dementia diagnosis, and was supported by 15% of GPs (see Table 1 for details on agreement with a factor). The majority of GPs (73%) exclusively agreed with enablers of early dementia diagnosis, 12% agreed with both enablers and barriers, and 3% exclusively agreed with barriers to early dementia diagnosis.
Association between GPs' attitudes and demographic characteristics or professional approach The regression results are presented in Table 2. Younger GPs were more likely than older GPs to agree with enablers but also with barriers to early dementia diagnosis. Compared to men, women were more likely to agree with barriers to early dementia diagnosis. GPs who reported a later average stage at first diagnosis (one point increase e.g. from "MCI" to "mild dementia") also agreed less with enablers of early dementia diagnosis. GPs with higher agreement of enablers of early dementia diagnosis were significantly more likely to take all the proposed measures after a hypothetical case of mild dementia diagnosis, except watchful waiting. GPs who agreed more with barriers to early dementia recognition would counsel family members less often after a diagnosis of mild dementia and would more often adopt a watchful waiting strategy. Further, GPs who agreed more with barriers to early dementia recognition would more often prescribe Ginkgo biloba after a diagnosis of mild dementia, and would test fitness to drive less often after a diagnosis of mild dementia. Table 2 about here.

Discussion
The main findings of this research are that 85% of respondents revealed a positive attitude towards early dementia recognition while 15% agreed that there are barriers to early dementia recognition. A minority showed nihilistic attitudes, believing that providing a patient with a dementia diagnosis is providing a diagnosis that is not clinically actionable (33%), or feeling that the present treatment options with anti-dementia drugs had no positive influence on the course of the disease (45%). GPs' self-reported positive attitudes towards enablers of early dementia recognition were associated with an increase in the number of measures taken after mild dementia diagnosis, and an earlier average point of first diagnosis. GPs reporting more often that there are barriers to early recognition of dementia would less often counsel family members or test fitness to drive. Instead they would more often use the wait and see strategy, or prescribe Ginkgo biloba. The generally positive attitude towards early dementia recognition and dementia care is consistent with recent literature findings indicating that GPs are dedicated to and concerned with caring for their patients with dementia, and that they acknowledge the benefits to patients and their carers of a timely dementia diagnosis at an early stage of the disease [20,[34][35][36][37]. Notably, this positive attitude was present although 45% of the respondents held the view that anti-dementia drugs had no positive influence on the clinical course of the disease. Variables loading most on the first factor were associated with long-term planning, taking into account not only physical and mental well-being, but also social aspects. GPs with this understanding are rooted in the thinking of advance care planning [38] and palliative care [39,40]. All these aspects are crucial in order to educate newly diagnosed patients and their family members about coping strategies and about maintaining independence [41].
The current results are in line with findings from other literature showing the significance of time and financial constraints for diagnostic assessments and post-diagnostic dementia management [9,20]. The current study showed that GPs agreeing more that there are barriers would more often choose the "wait and see" approach to diagnosis and management, less often test fitness to drive or counsel relatives. Thus, GPs negative attitude may threaten optimal management of persons with dementia increasing the likelihood that dangerous situations, stress or crisis for the patient and relatives would occur. Attitudes based on a "therapeutic nihilism" were not prevalent among current respondents. In fact, only 18% agreed that managing dementia is more often frustrating than rewarding, which is in accordance with recent findings [42]. Nevertheless, 36% of current respondents agreed that providing a patient with a dementia diagnosis is providing a diagnosis that is not clinically actionable, which seems to be more frequent compared with findings from literature (5%) [37]. Time of diagnosis does not solely depend on GP's, but also is a patient and patients' caregiver issue. Findings of a focus group study with people with dementia, informal carers and health and social care professionals in eight European countries has shown that the attitudes and beliefs of people with dementia and their carers may have a major impact on the access to formal care, and they often serve as barriers [43]. Formal care was perceived as a threat to the individual independence of people with dementia and was thus avoided as long as possible. Thus, if patients generally present later to GPs, this may compound with GPs therapeutic nihilism.
We have seen that most GPs agreeing that there are barriers to early dementia recognition at the same time agree with the enablers of early dementia recognition. Thus, it is important to motivate and empower those GPs. Political measures involving e.g. monetary incentives appeared to have been effective in closing the gap between recorded and expected prevalence of dementia in primary care [44][45][46]. Since there are no signs of significant progress in dementia therapy in the foreseeable future, we suggest that GP training should combine positive attitudes towards dementia care with a special focus on a holistic advance care planning approach to care for patients with dementia. This should include their caregivers in order to prevent crises, and should involve the patient in the decision-making process [38,47]. Hopefully, the proposed approach will provide GPs who will lose or have lost their belief in the efficacy of anti-dementia drugs with a viable alternative. Recent surveys in Europe indicate that positive attitudes towards early dementia recognition and care are becoming more prevalent [37,45]. The limited response rate of 21% may compromise the generalisability of the results, although a 20-30% participation rate is very common in population-based surveys in primary care [48][49][50]. In particular in view of the low priority with which dementia is regarded by GPs [51], we anticipated a low participation rate. The low response rate might lead to selection bias, e.g. an over-representation of GPs who were interested in the topic of dementia, thereby overestimating the positive attitude to early dementia recognition. Considering demographic characteristics, the respondents differed minimally from the total sample in terms of gender (70% vs 69% males), age and language region. Respondents were in average 1 year younger than in the total sample (55.8 vs 56.7 years) and there were more German-speaking respondents than in the total sample (79% vs 75%) (see Supplementary Information S 2). Another limitation is that the ratings represent the GPs' perceptions, and their judgements may lack objectivity.

Conclusions
In the light of recent disappointing results of both systematic reviews of existing anti-dementia drugs [52] and clinical trials with newer anti-dementia drugs [53,54], GPs estimate the effectiveness of available anti-dementia drugs on the course of the disease to be low. However, the attitude of the majority of GPs is not characterized by diagnostic or therapeutic nihilism. In particular, young GPs favour early diagnosis of dementia for timely advance care planning, prevention of dangerous situations, and timely counsel and support for relatives and patients with the aim of influencing disease outcome and delaying institutionalization. These measures are time consuming and costly, which could jeopardize the success of this desirable approach. Health systems are therefore required to critically scrutinize the use of available resources. It is essential to support training, care and research that will allow GPs to look after patients and their relatives in a holistic way, so that they can manage and live with the diagnosis of dementia.

Additional file
Additional file 1: Table S1. Stages of dementia at the point of first diagnosis used in the questionnaire. Table S2. Demographic, regional and professional characteristics of the respondent GPs. Table S3. Frequency of agreement with attitudes towards timely diagnosis (N = 882). Table S4. Frequency and summary statistics of measures taken after the diagnosis of mild dementia. Table S5. Supplementary information on exploratory factor analysis. Table S6. Figure: Ranked attitudes regarding dementia recognition and care. Attitudes were ranked according to GPs' agreement.  Est beta coefficient of linear regression, CI confidence interval For each unit increment of the independent variables (e.g. in the frequency of an intervention from 0 to 25% of cases or for each increment in the average moment of first diagnosis from MCI to mild dementia), the attitude of GPs changed by the indicated estimate on a scale ranging from 1 to 5. The multivariable models were adjusted for age, work (hours per week), practice location (city, agglomeration of the city, countryside), and the estimate of the percentage of patients over the age of 70