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Regulation of adiponectin in adipocytes upon exposure to HIV‐1

Adipose dysregulation, dyslipidemia, and insulin resistance are hallmarks of HIV‐related lipodystrophy. The precise mechanisms behind these disturbances are unknown. In HIV‐infected patients, we previously demonstrated a strong relationship between lipodystrophy and levels of adiponectin, an adipose peptide implicated in regulation of glucose and lipid metabolisms. In this study we investigated the effect of HIV on adipocytes, to determine whether HIV can directly infect adipocytes and/or alter the regulation and secretion of the adipocyte‐derived hormone adiponectin.