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Bacterial uptake of aminoglycoside antibiotics.

The uptake or accumulation of aminoglycoside antibiotics by bacterial cells is a research area that is now more than 25 years old, yet the fundamental mechanisms by which these compounds find their way across the procaryotic cell envelope to their ribosomal targets are still obscure. In this manuscript, we try to present a critical overview of the subject and address a number of unresolved issues about the overall process of aminoglycoside uptake to suggest directions for future research. While not attempting to be comprehensive, we hope to cite the most critical papers and