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Localization of hematopoietic progenitor cells in tissue with the anti-My-10 monoclonal antibody.

Putative hematopoietic progenitor cells were localized in human lymphoid and nonlymphoid tissues with the use of the anti-My-10 antibody and avidin-biotin immunoperoxidase. Groups of My-10+ round mononuclear cells were evident in the splenic marginal zone near the follicular mantle. My-10+ cells were also evident in the hepatic portal triads and rare cells were seen near Peyer's patches. Except for My-10+ endothelial cells, there was no staining of the thymus, lymph node, skin, or kidney specimens.