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Proceedings: Influence of tetrodotoxin on the contractile response of the small intestine of guinea-pig produced by picric acid and acetylcholine.

Contraction of the small intestine of guinea-pig by PA (2×10-4M) was completely inhibited after administration of TTX (10-7M), whereas higher concentration of MP or PP was required to produce a comparable inhibition of the effect of PA. After treatment with TTX or MP (both 5×10-7M), there was a slight enhancement of contraction by Ach (10-7M), while the same concentration of PP failed to produce any appreciable effect for Achinduced contraction. Pretreatment of 10-4M of PP resulted a certain degree of inhibition of Ach-induced contraction, whereas no effect was exerted at all after comparable doses of TTX or MP. When the tissue was pretreated with TTX (5×10-7M), there were a suppression of the Ach liberation by PA (2×10-4M) and a slight reduction of the Ach uptake by tissue. These results seem to indicate that TTX, like MP, having affinity for the terminal cell of cholinergic nerve but being devoid of effect on the effector-cell, inhibits the release and uptake of Ach.