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Long‐term antinociception by electroacupuncture is mediated via peripheral opioid receptors in free‐moving rats with inflammatory hyperalgesia

Electroacupuncture (EA) has been widely accepted and applied as an important acupuncture‐related technique for acupuncture analgesia (AA) research. The involvement of opioid peptides and receptors in acute AA has been shown via pre‐EA application of opioid receptor/peptide antagonists. In this study, we intended to reproducibly institute acupoint position and needling excluding influences from anaesthesia or restrainers on rats with complete Freund's adjuvant (CFA) hind paw inflammatory pain, as well as to explore opioid‐dependency and anti‐inflammatory effects in sustained acupuncture analgesia.