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Metabolic fate of mineral oil adjuvants using 14C-labeled tracers. II. Mannide monooleate.

Abstract This investigation was undertaken to determine the metabolic fate of mannide monooleate when employed in a mineral oil emulsion. Female white rats and female squirrel monkeys were injected subcutaneously or intramuscularly with an emulsion made with mineral oil and surfactant and including either 1- 14 C-oleate or UL- 14 C-mannide-labeled mannide monooleate tracer preparations. It was shown that 30-40% of the surfactant mixture is removed from the site of injection after 24 hr. After 1 week, 40-60% of the surfactant is removed from the site of injection; while after 3 months, 10-30% of the surfactant still remains. The 1- 14 C-oleatelabeled mannide monooleate was largely incorporated into the various lipid classes, while the UL- 14 C-mannide-labeled mannide monooleate preparation was largely eliminated in the urine. There was some indication that the inguinal lymph nodes of monkeys may have contained unusually large amounts of radioactivity.