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Radiotherapy enhances the toxicity of aminoglutethimide.

We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer. This patient was started on aminoglutethimide 6 days prior to radiation therapy, for painful bone metastasis. On day 7 of radiation therapy, she developed an extensive erythematous maculopapular rash over her face, trunk, and extremities. The rash was confluent over the radiation ports, both anteriorly and posteriorly. Aminoglutethimide was discontinued until completion of radiotherapy, and the rash resolved. Concomitant irradiation apparently enhanced the skin toxicity of aminoglutethimide or possibly aminoglutethimide had a radiosensitizing role in this patient.