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Paraoxonasel phenotype distribution in Thais.

OBJECTIVE
To determine the PON1 activity and phenotype distribution in a Thai population.


STUDY DESIGN
Prospective Descriptive study.


MATERIAL AND METHOD
Between October 2001 and April 2002, 160 healthy Thai individuals aged 20-74 years were assessed for PON1 activity and the phenotype distribution by using dual substrate method.


RESULTS
The means +/- SD of basal, salt-stimulated paraoxonase and arylesterase activities were 239.7 +/- 83.9 nmol/min/mL 555.2 +/- 222.2 nmol/min/mL and 147.6 +/- 33.8 micromol/min/mL respectively. The authors observed a wide interindividual variability up to 6.9-fold for paraoxonase activity and 4.6-fold for arylesterase activity. The authors found a range of ssPON/ARE ratio from 1.04 to 7.05 and three distinctive phenotype modals of AA (1.04-2.25), AB (2.44-4.29), and BB (4.53-7.05) with frequencies of 14.4% (AA), 51.9% (AB), and 33.7% (BB). The authors also observed the association of sex with lipid parameters and PON1 activity.


CONCLUSION
The distribution of PON1 phenotype in Thais is clearly trimodal with high frequency in BB phenotype.