{'fraction_non_alphanumeric': 0.032917139614074914, 'fraction_numerical': 0.0022701475595913734, 'mean_word_length': 6.35, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Nerve Growth Factor and its Functional Receptor TrkA are Up‐regulated in Murine Decidual Tissue of Stress‐triggered and Substance P‐mediated Abortion

Problem:  Stress, elicited by environmental and social conditions, is known to affect the homeostasis of the nervous, endocrine and immune systems. In pregnancy, perceived stress results in a predomination of inflammatory abortion‐associated Th1 cytokines over immunosuppressive, pregnancy‐protective‐associated Th2 cytokines, putatively via neuropeptide substance P (SP). Nerve growth factor (NGF), an important trophic factor for sympathetic neurons, has been implicated in the responsiveness of immune‐competent cells through its functional receptor, tropomyosin receptor kinase (TrkA). Thus, the aim of the present study was to identify a cross‐talk between distinct neurotrophic and immune mediators in pregnancy maintenance.