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Antenatal fetal heart rate variation in relation to the respiratory and metabolic status of the compromised human fetus

Summary. Three groups of women were delivered by caesarean section before labour: for an abnormal fetal heart rate (FHR) trace (21 cases, group 1), or for maternal deterioration in severe pre‐eclampsia without gross fetal heart rate abnormalities (20 cases, group 2), or to avoid mechanical difficulties in labour at term (30 cases, group 3). The mean gestational ages of the first two groups were 32 weeks with a high proportion of infants small‐for‐gestational‐age. In group 1, FHR variation (mean range of pulse intervals) was less than half (20·6 SE 1·2 ms) of the normal value at the same age (44·4 SE 1·5 ms). This was associated with hypoxaemia (mean umbilical artery Po2 of 6 mmHg at delivery), with evidence of compensation shown by an elevated amniotic fluid erythropoietin. The fetuses were hypoglycaemic and had greater umbilical artery blood alanine concentrations, but no large changes in adenine nucleotide or endorphin plasma concentrations. Although there was a minor degree of respiratory acidaemia at birth, there was not significant metabolic acidaemia. The results demonstrate that the reduced variation of ‘suboptimal’ and ‘decelerative’ fetal heart rate records is associated with fetal hypoxaemia and evidence of nutritional deprivation, but not with asphyxia.