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Renal crisis in asclerodermic scleroderma—lupus overlap syndrome

A 24-year-old woman with overlappingfeatures of sclerodermia sine scleroderma and systemic lupus erythematosus (SLE) presented with rapidly acceleratinghypertension accompanied by neuropsychological deficits and tonic—clonic seizures. Kidney biopsy showed severe intimal hyperplasia of small renal arteries but no glomerulonephritis. Following treatment with ACE inhibitor, prednisolone and cyclophosphamide complete remission was achieved with minimal brain damage and normal kidney function. Anti-RNA polymerase I, II and III antibodies have remained positive during follow-up for 2 years, suggesting a linkage with the underlying pathogenetic pathway.