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Flow cytometric osmotic fragility—An effective screening approach for red cell membranopathies

Among the red cell membrane disorders, hereditary spherocytosis (HS) is one of the most common causes of inherited hemolytic anemia. The aim of this study was to compare the flow‐cytometric approach for screening of red cell membrane disorders based on osmotic fragility with the eosin‐5‐maleimide (E5′M) dye test. A group of β‐thalassemia heterozygotes were also studied.