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Markers of thrombosis in patient with thrombophilia

Introduction: thrombophilia is a clinical condition characterized by an excessive tendency to arterial or venous thromboembolism due to diverse reasons, included genetic and acquired causes, as well as their interactions. It produces high morbidity and mortality. Objective: to characterize the behavior of thrombogenesis markers in patients diagnosed with thrombophilia, to determine the association of these with the occurrence of thrombotic complications and to determine the association between genetic markers and genetic-acquired recurrence of these complications. Method: 107 patients fromed the sample (males and females, ages younger than 45). They were assisted in the thrombophilia consultation at Hermanos Ameijeiras Hospital, from February 2011 to September 2012. As part of the thrombophilic profile, antithrombin (AT), proteins C and S (PC, PS), and lupus anticoagulant (LA) were assessed by chromogenic and coagulometric studies. The genetic disorders such as Factor V Leiden (FVL) and and Factor II G20210 A (PG20210A) were studied by polymerase chain reaction. Results: a prevalence of white race was seen for developing thrombotic events, with a higher number of patients with thrombogenic markers and combinations for this ethnic group (x=19.52 and a p=0.001). Both genders had equal probability to develop thrombotic events (x=0.512 and a p=0.4750). The appearance of vein occlusive events and their recurrence was more frequent in the studied patients (x=59.16 and a p=0.000 and an x=8.7 and a p=0.003 respectively) and this frequency increased, when associated to acquired risks (x=18.13 and a p=0.000). The prevalent genetic marker in patients with thrombosis was FLV x=16.2 and a p=0.000 for an OR=11.9; IC=2.72-52.5. Conclusions: these results are very important in predicting the recurrence of thrombotic events so as to take the prophylactic and therapeutic measures needed in patients with thrombophilia.