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Channel multiplexing recording system for Microelectrode Array

Microelectrode Array (MEA) have been used for electrophysiological signal recording of the activity of neuron cells. These signals are used to the study of the neuronal network dynamics in neuroscience; as well as for the drug tests in pharmacological applications, between others. The majority of MEA recording systems in the world, needs several amplifier blocks (one per channel). These amplifier blocks, always in a great number, result in a very complex and high cost implementation. It is proposed a novel data acquisition system for a MEA of 60 microelectrodes, in this paper. The prototype tests showed that the recording of microelectrode signals at mV level, using a single headstage pre-amplifier, filter, amplifier, analog-to-digital converter, and USB converter, are feasible.