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In Situ Forming and Reversibly Cross-Linkable Hydrogels Based on Copolypept(o)ides and Polysaccharides

The emerging tide of hydrogels in biomedical fields drives them to possess good biocompatibility, tunable mechanical properties and fast gelation process. Herein, a composite hydrogel containing copolypept(o)ides and functional polysaccharides were constructed through dynamic acylhydrazone linkages. Firstly, a series of peptide-peptoid copolymers were synthesized by ring opening polymerization of sarcosine (Sar) and L-glutamic acid -benzyl ester (BLG) N-carboxyanhydrides (NCAs). The benzyl groups of BLG units were substituted with hydrazide groups through ester-amide exchange aminolysis reaction. The statistical copolymer of poly(sarcosine-co-glutamate-hydrazide) (P(Sar-co-GH)) was chosen as an optimized precursor due to its excellent water-solubility and gel-forming ability with aldehyde modified sodium alginate (OSA). Moreover, cellulose nanocrystals (CNCs) were prepared as nanofillers to reinforce the P(Sar-co-GH)-OSA hydrogel. We demonstrated that the copolymer sequences and composition contents made...