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[Influence of ginsenoside Rb1 and Rg1 on some central neurotransmitter receptors and protein biosynthesis in the mouse brain].

Effects of ginsenoside Rb_1 and Rg_1 on seven kinds of central neurotransmitter receptors, α_1, α_2 and β-adrenoceptors, 5-HT, DA, GABA and M-cholinergic receptors, were measured. Results showed that no specific binding of Rb_1 and Rg_1 to any of these kinds of recptors was observed. However, 5 days after i. p. injection of Rb_1 and Rg_1 higher Bmax values were observed for the brain membranes from treated mice than those from control mice. Rb_1 and Rg_1 were also shown to increase protein biosynthesis in mouse brain. The findings may be helpful to elucidate ginseng's mechanism of central actions.