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Brain energetics and neurosurgery. A review of recent studies done at Duke University.

✓ Consecutive studies of brain energetics undertaken at Duke University during a period of 5 years are described. Various forms of stress such as hypoxia, hyperbaric oxygenation, and selected drugs were used to depict quantitative adverse effects upon the brain's basic energy system, and protectant measures evaluated including hypothermia and appropriate substrates. A systematic survey of substrate protectants was carried out in laboratory animals, and the theory and practice of preserving brain energy levels explored. A foundation for clinical application has been established.