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Comparison of therapeutic agents for synthetic pyrethroid exposure

Synthetic pyrethroids are highly active insecticides that possess a low mammalian toxicity, are rapidly metabolized, and leave practically no residue in the biosphere (1 ). All pyrethroids are lipophilic compounds that are practically insoluble in water and are recognized as nerve poisons. Increased usage in the past 7 years has established pyrethroids as a major class of pesticide chemicals (2). With increased usage, the number of reports of cutaneous dysesthesia among individuals occupationally exposed to synthetic pyrethroids has also increased (3). The cutaneous sensation that results from exposure typically occurs without erythema, edema, vesiculation or any other sign of dermal irritation. A new assay method, developed in this laboratory, has proven to be extremely sensitive in the detection of this dermal sensation ( 4).