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THE DYNAMICS OF ANTIOXIDANT ACTIVITY OF BLOOD SERUM AND INTESTINAL CONTENT IN EXPERIMENTAL ANIMALS IN SIMULATED ACUTE INTESTINAL OBSTRUCTION

The article studies the changes of antioxidant activity of blood serum and intestinal content in experimental animals 12, 24, 36 hours after simulated acute intestinal obstruction (AIO). The experiment included 77 adult male inbred albino rats, which were included into trial (n = 27) and control (n = 50) groups. AIO in the rats is accompanied by inhibition of antioxidant properties of the serum and intestinal content, the development of endotoxemia already within the first day of AIO. The animals with AIO have unidirectional changes of the antioxidant status in the serum and intestinal content, but later occurring with greater intensity. These data show the need for application of antihypoxic oriented drugs in the comprehensive therapy program of AIO treatment.