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Radiotherapy for in situ extramammary Paget disease of the vulva.

BACKGROUND
Radiotherapy as a first-choice treatment for in situ extramammary Paget disease has been successfully used.


OBJECTIVES
To review the most relevant aspects of radiotherapy as first-choice treatment in selected cases of in situ extramammary Paget disease of the vulva.


PATIENTS AND METHODS
Two Caucasian females aged 76 and 92 years with in situ extramammary Paget disease localized in the genital region were treated by means of ortovoltage X-rays: 100 kV, 8 mA, 1.7 mm Al filter, field size of 12-cm cone, and source skin distance of 30 cm. Both patients received 40 Gy, 200 cGy per fraction, five fractions per week.


RESULTS
Complete regression of in situ extramammary Paget disease was observed in both patients after radical radiation therapy and neither local recurrences nor internal malignancies were detected.


CONCLUSIONS
Radiotherapy is a curative treatment in selected cases of in situ extramammary Paget disease affecting the vulva.