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Effect of a Low–Fluoride–Content, Two–Component Rinse on Fluoride Uptake and on De– and Remineralization of Enamel Lesions: An in vitro Study

The effect of calcium (Ca) concentrations and added ethanol on fluoride (F) depositions by experimental two–component rinses, each consisting of a Ca–containing and an F–containing component, was evaluated in an in vitro system. Among the tested rinses, a 3 mmol/l F two–component rinse with 200 mmol/l Ca and 10% v/v ethanol was found to produce the greatest F deposition relative to the F concentration in the rinse. Specifically, this rinse produced an F deposition that was about 7 times greater than a conventional 13.2–mmol/l sodium fluoride (NaF) rinse. In a second experiment, an in vitro pH cycling model was used to evaluate the potential anti–caries effects of 4 rinses: (1) placebo rinse (no F), (2) 13.2–mmol/l NaF rinse, (3) 52.6–mmol/l NaF rinse, and (4) the 3–mmol/l F two–component rinse in a 7–day in vitro pH cycling model. The changes in lesion mineral contents, delta(ΔZ), as assessed by quantitative microradiographic measurements, were as follows [mean ± standard deviation, n = 10]: (1) 72.5±10.2 µm, (2) 43.4±5.6 µm, (3) 17.3±10.2 µm and (4) 45.3±5.2 µm. These results showed that the 3–mmol/l F two–component rinse produced the same (p>0.05) protection against demineralization as did the 13.2–mmol/l NaF rinse which had 4 times the fluoride content. The results suggest that it is possible to formulate an effective low–F two–component rinse.