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The Role of Estrogen in Bone Turnover with Aging and Age-related Osteoporosis

In this paper we discuss something about The Role of Estrogen in Bone Turnover with Aging and Age-related Osteoporosis. Osteoporosis is a common disease characterized by reduced bone quality and increased risk of fragility fractures. Age-related osteoporosis happens gradually and spontaneously with aging as the result of bone loss. Women older than 50 years old have higher risk to get osteoporosis resulting from the drop of the estrogen level during the menopause. Every year, nearly 32% of Chinese women older than 50 years old get suffered by the age-related osteoporosis. Osteoporotic patients have higher risk of bone fracture due to the weaker bone quality, the estimated cost of bone fracture treatments keep rising to $20 billion in 2035. Bone health and healthy bone quality maintenance have becoming the most important aspect for ensuring and improving the quality of life for elderly people. This review article aims to explain the cause of age-related osteoporosis from several detailed aspects, from bone components to bone cell functions. The main purpose of this article is to elucidate the relation between estrogen and age-related osteoporosis, explaining how the drop of estrogen level with aging lead to serious bone mass loss. We hope that by reading this brief review, people are able to get ideas about the importance of protecting and strengthening bone quality to protect skeleton from potential future bone mass loss.