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Sex differences in global and regional cardiac function in response to acute hypoxia

It is widely known that physiological differences between males and females result in differences in cardiac mass and volumes. There are conflicting results on whether differences in cardiac mass and volumes result in functional differences between males and females, with some reports suggesting increased or no difference in contractile function in females as compared to males. Moreover, very little information exists on whether cardiac sex differences exist under conditions of stress, such as hypoxia. Therefore, we hypothesized that females would demonstrate greater systolic and diastolic function during acute hypoxia. Using cardiac magnetic resonance imaging (MRI) we assessed global and regional cardiac functional response of males and females exposed to acute hypoxia.