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A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin.

A new mast cell degranulating peptide was isolated from the frog skin. The peptide possesses a notable sequence, in which hydrophobic amino acid residues are in the N-terminal, and hydrophilic and basic amino acid residues in the C-terminal region. Granuliberin-R belongs to a new family of the active peptides in the amphibian skin.