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Identification of a Critical Amino Acid Position Conferring G‐protein Bias to Delta Opioid Receptor Peptides

The delta opioid receptor (δOR) is a G‐protein coupled receptor that presents as a promising target in the potential treatment of mood, anxiety and alcohol use disorders. Thus far, attempts at the clinical development of δOR agonists have not met desired end‐points, which may be related to the risk of seizures associated with some δOR agonists. Previous studies have associated δOR agonist induced seizures to an agonist's efficacy in recruiting β‐arrestin proteins. Thus, it has been hypothesized that δOR agonists that display minimal β‐arrestin recruitment may show greater promise in developing into successful clinical therapies. A big current limitation in readily producing such signal biased drugs is a lack of conformational insight into such biased signaling. Recently, we determined that the naturally derived rubiscolin peptides YPLDL and YPLDLF possess a preference or signaling bias towards Gi protein over β‐arrestin recruitment. Here we hypothesize that the conformationally restricted nature of proline may be contributing to the G‐protein bias of these peptides.