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Volumetric Raman chemical imaging of drug delivery systems

: The ability to image drug distribution inside a several hundred-micron thick polymer matrix, en-capsulated by a protective coating, would greatly contribute to the understanding of the performance and short-comings of drug delivery devices. Here, we present an experimental framework for deep volumetric Raman imaging (dVRI), where common challenges such as low Raman cross section, fluorescence and low transparency of samples are overcome. We apply dVRI to a selection of drug delivery forms; tablets with thin protective coatings and drug-loaded microdevices. We demonstrate 3D visualization of the different drug/polymeric materials, constituting a drug delivery device, with imaging depth of 225µm. low Raman cross section, fluorescence and low transparency of samples are overcome. We apply dVRI to a selection of drug delivery forms; tablets with thin protective coatings and drug-loaded microdevices and demonstrate 3D visualization of the different drug/polymeric materials, constituting a drug delivery device, with imaging depth of 225µm.