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The effect of adenosine and B2-tetrabutyrate on high lipid blood animals.

When a study was made on the change of B2 quantity in organs by the joint administering of Adenosine and B2-tetrabutyrate, increase of B2 quantity was observed in liver, kidney and heart in drug administered group than in control group. Fractional quantitative analysis by paper chromatography was carried out, by which the FAD fraction in liver, kidney and heart was registered as increasing, and it is considered that total B2 quantity increased in each organ has increased as the result. Considerable increase is also registered in group administered with B2-tetrabutyrate alone as compared with control group, but the group jointly administered with Adenosine showed tendency of growing FAD at higher ratio. It was considered that the fact is substantiated that Adenosine is fully participating as the necessary material in the process of B2-tetrabutyrate becoming FR in the body, and still further to become FAD. As regards the inhibiting effect by B2-tetrabutyrate against test rabbit of high lipid blood, there are tests, et., by Kishikawa et al, but also in the case of author et al, considerable inhibiting effect was observed in cholesterol and triglyceride etc., as compared with control group. Besides, the result was obtained that this effect gets stronger by the joint use of Adenosine. Still more detailed experiment will be necessary in order to ascertain that this is the activity of Adenosine itself, indirect activity of Adenosine becoming nucleotide, or in the relationship with FAD. This time, inhibiting effect against rabbit of high lipid blood by single administering of Adenosine was studied, and remarkable inhibiting effect was observed by Adenosine in cholesterol value, triglyceride and phospholipide etc. As stated already, when it is considered that Lentinacin having Adenine skeleton possesses de-cholesterol activity, it is considered that these series of compounds may have de-cholesterol activity. On the basis of general classification, as mechanism of serum cholesterol lowering, which are (1) hindrance to absorption from digestive canal, (2) hindrance to biosynthesis, (3) promotion of metabolic evacuation, (4) change of bodily distribution, the case of Adenosine is supposed due to promotion activity of metabolic evacuation as in the case of Lentinacin, but as it is only in a stage of presumption, further study is desired to be made. On the basis of above animal tests, the therapy of joint use of Adenosine and Adenosine as well as B2-tetrabutyrate for abnormal metabolism of lipid should be attempted hereafter.