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Herpes Vegetans and Review of Verrucous Lesions of the Anogenital Region

Abstract Herpes vegetans is one of the rare atypical presentations of herpes simplex virus in immunocompromised patients such as those with human immunodeficiency virus (HIV) infection, which presents as an exophytic, proliferative lesion that resembles either a verrucous or a malignant growth. Patients with immunosuppression as in HIV infection may experience more frequent and more severe recurrences of genital herpes. They are also more likely to be resistant to standard antiherpetic agents such as acyclovir. Herpes simplex virus infection in patients with immune suppression such as HIV can also be atypical in morphology and present a diagnostic and therapeutic challenge. The verrucous lesions of the anogenital region can be similar in many causes of, and it is important to look for subtle differences in appearance and use a variety of diagnostic methods to arrive at a correct diagnosis. We performed a literature review of the verrucous lesions in the anogenital region and also report a case of herpes vegetans.