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Blind attraction: The mechanism of an inherited congenital cataract

Cataract is the leading cause of blindness in the world, and most cataracts are age-related (1). The proteins in the lens degrade with time, and the subsequent aggregation of the modified proteins produces an increase in light scattering, and hence a loss of vision (2). There are cases, however, in which cataract is an inherited single-gene disorder. Currently, around 60 such cataracts have been identified (3). In these cases, the cause of the disease is a mutation in the genes that code for the lens proteins. Unlike age-related cataracts, inherited cataracts occur in children as well as adults (4). In PNAS, Banerjee et al. (5) report a previously undescribed mechanism for an inherited congenital cataract. They carefully examine the delicately balanced interactions among the lens proteins that maintain the proper function of the lens.