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Advances in understanding the biology and function of the G‐CSF receptor

G‐CSF is the major growth factor involved in the production of neutrophilic granulocytes. G‐CSF exerts its function via the activation of a membrane receptor that belongs to the superfamily of hematopoietin receptors, also referred to as class I cytokine receptors. In this review we summarize the current knowledge of the function of the G‐CSF receptor in normal granulopoiesis, as well as in some patients with severe congenital neutropenia and acute myeloblastic leukemia, diseases characterized by disturbed myeloid maturation.