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A technique for detecting rejection episodes in human transplant recipients using radioactive fibrinogen

Radioactive 125I‐labelled human fibrinogen was given to 32 patients who had received renal transplants. In each case radioactivity was measured over the transplant and expressed as a percentage of the value recorded over the heart. Recipients that were experiencing rejection episodes had higher levels of radioactivity over their transplants when compared with patients who were free of rejection at the time. It is suggested that this technique could be of value in the diagnosis of rejection episodes, particularly in those recipients who remain oliguric after transplantation.