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Bioavailability of selenium from selenium‐enriched milk assessed in the artificially‐reared neonatal pig

There is interest in pre‐farm gate enhancement of selenium (Se) content in animal products to improve public health, particularly if the Se is highly bioavailable. Milk enriched with Se (1070 μg Se/kg DM; HSeM) was obtained from cows fed a supplemental diet containing Sel‐Plex® (Alltech Biotechnology P/L) while the control diet (135 μg Se/kg DM; LSeM) was made using milk powder from non‐supplemented cows. Additional diets were formulated by adding Sel‐Plex® (HSP) or selenate (HSN) to the LSeM diet to give Se concentrations of 1070 μg Se/kg DM. Neonatal pigs (n=54) at 2d of age were trained to drink milk and after a further 3d, were randomly allocated to their 4 respective diets (1.7 MJ/kg BW) and slaughter times (0, 7, 14, 28 and 42d of feeding). For pigs receiving HSeM there was a rapid increase in plasma Se over the first 7d after which there was a gradual increase for a further 14 d and then plasma Se was maintained 3x higher than the LSeM pigs. Plasma Se concentrations in the HSP and HSN pigs increased by 20–25% over the first 14d and then plateaued. Between 14 and 42d plasma Se levels were 45, 125, 122 and 170 μg/L for LSeM, HSN, HSP and HSeM pigs, respectively (P<0.001). Muscle Se reached a plateau after 28 d of feeding. Between 28 and 42d muscle Se levels were 47, 106, 237 and 486 μg/kg for LSeM, HSN, HSP and HSeM pigs, respectively (P<0.001). These data suggest that Se in milk from cows fed Sel‐Plex® is highly bioavailable and may offer a means of delivering supplemental Se to humans.