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α, β and γ T‐cell receptor genes: rearrangements correlate with haematological phenotype in T cell leukaemias

We have studied the arrangement of the α, β and γT cell receptor (TCR) genes in 27 patients with T cell lymphoproliferative disorders. Nine patients had acute lymphoblastic leukaemia (T‐ALL), nine patients had prolympho‐cytic leukaemia (PLL), six patients presented with a T‐CLL/T‐lymphocytosis syndrome, two patients had Sezary syndrome (SS) and one patient had HTLV‐I positive T‐cell leukaemia/ lymphoma (ATLL). α TCR gene rearrangement could be demonstrated by the use of three available probes in only one case. By contrast, both β and γ TCR gene rearrangement could be demonstrated by Southern blot analysis of DNA samples digested with appropriate restriction enzymes in the majority of cases. In general, when rearrangements were present they involved both alleles. The proportion of rearranged chromosomes was lower in T‐ALL than in other forms of T‐cell leukaemia and it was lower in cases with the CD4 —/ CD8+ phenotype than in those with a CD4 +/CD8—phenotype. In three out of 34 cases of B‐cell leukaemia the TCR β‐gene but not the TCR γ‐gene was rearranged, just as in two out of 26 cases of T‐cell leukaemia the immunoglobulin (Ig) heavy chain but not the light chain genes were rearranged.