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Acute Toxicologic Evaluation of Polyphosphonate

Oral Lethalitv Protocol: Two groups of5 male and 5 female young adult rats (I 72!176g) were dosed at 3100 and 5000 mg/kg. The animals were observed for mortality, body weights, clinical signs and gross pathological changes through day 14. Results: Corresponding mortality was 0 and 20% respectively. Clinical signs at 5000 mg/kg included poor general condition and piloerection. Onset of symptoms was ca. 8 h p.a .. On day 4 all survivors were free of signs. Deaths occurred from day 2 to day 4. Dead animals showed loss of mucosa relief of the stomach. Necropsy at day 14 revealed no abnormalities. The acute oral LDso for male and female rats is > 5000 mg/kg.