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External validation of the OPALS prediction model for in-hospital mortality in patients with acute decompensated pulmonary hypertension

We were very pleased to read the article “Critical care outcomes in patients with pre-existing pulmonary hypertension: insights from the ASPIRE registry”, recently published in ERJ Open Research [1].

Predicting outcomes early at ICU admission may be useful for decision-making in terms of interventions and to understand the clinical course of acute decompensated PH [3,4]. We aimed to test and externally validate the OPALS score in our cohort according to the TRIPOD checklist for transparent reporting of a multivariable prediction model for individual prognosis [5].
To test the hypothesis that the OPALS score was associated with in-hospital mortality in our cohort, we employed multivariate logistic regression. We evaluated the predictive performance of the OPALS score, examining the calibration and discrimination of the regression model. Calibration was evaluated by plotting observed proportions versus predicted probabilities, and by calculating the calibration slope and intercept. Discrimination was assessed with the area under the receiver operating characteristic curve (AUC-ROC). Statistical analyses were performed using SPSS software (version 23.0: IBM, Armonk, NY, USA). A p-value ⩽0.05 was considered significant.
Our cohort had fewer patients (73 medical patients) than the original OPALS cohort (242 total patients, 147 medical patients) but was similar regarding demographics, PH severity and in-hospital mortality. Compared to the OPALS cohort, our patients were of similar age (median age 48 versus 52 years), sex (females 75% versus 68.2%), type of PH (group 1 64% versus 67%). Severity of PH based on the number of patients in New York Heart Association functional class III-IV was similar (76.3% versus 83.5%). Variables used in the OPALS score, such as sodium and platelets, were also similar between both cohorts (median sodium 136 versus 135 mEq·L −1 and median platelets 179 versus 194×10 9 L −1 ). In our cohort, lactate and S pO 2 /F IO 2 ratio were higher than in the OPALS cohort (lactate 2.0 versus 1.2 mmol·L −1 and S pO 2 /F IO 2 267 versus 168). In-hospital mortality in our cohort was quite similar (41.1% in our cohort versus 40.7% in medical patients of the OPALS cohort). The OPALS score model calibration plot and discrimination receiver operating characteristic curve are shown in figure 1. The intercept was −0.07 (95% CI −0.17-−0.03) with a slope of 1.05 (95% CI 0.90-1.19). R 2 was 0.97, indicating a high calibration between model performance and actual outcome. The OPALS score had an AUC-ROC of 0.77 (95% CI 0.66-0.88) to predict in-hospital mortality, similar to the AUC-ROC described in the original study (0.78). On our cohort, OPALS showed sensitivity of 0.60 (95% CI 0.40-0.77%), specificity of 0.76 (95% CI 0.61-0.88%), positive predictive value of 0.64 (95% CI 0.49-0.76%) and negative predictive value of 0.73 (95% CI 0.63-0.81%). Using the cut-off of OPALS ⩾2.5, as proposed in the original cohort, to predict in-hospital mortality, the unadjusted odds ratio for in-hospital mortality was 3.19 (95% CI 1.54-6.70).
In conclusion, the performance of the OPALS score in our cohort was similar to that in the derivation cohort, with very good calibration and similar discrimination. The main limitations in the present study are the small sample and the retrospective design. However, the lack of missing data and the robust methodological approach used for this external validation adds important information for physicians involved in the care of critical patients with PH.
Further studies are needed to evaluate the OPALS model in larger cohorts. Acute decompensation of PH remains a challenging complication of advanced PH. Multicentre collaboration is necessary to develop robust clinical models that can support clinical decisions.  19). b) The receiver operating characteristic curve of the OPALS score for predicting in-hospital mortality among patients admitted due to acute decompensated pulmonary hypertension in out cohort.