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Proteomic similarities in Alzheimer’s disease and epilepsy brains highlight the important role of tau

Alzheimer's Disease (AD) patients are more likely to experience epileptic seizures, and cognitive impairment is a frequent comorbidity in patients with epilepsy. Emerging findings indicate a common link between epilepsy and AD, however our understanding of the pathological changes shared between these two diseases is limited. Therefore, our aim was to determine whether there are common protein changes associated with both epilepsy and AD using an unbiased proteomics approach.