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1514 PROGNOSTIC SIGNIFICANCE OF NEONATAL INTRAVENTRICULAR HEMORRHAGE: FOLLOW-UP RESULTS FROM DISCORDANT TWINS

During a 3-year period, our newborn service admitted 13 pairs of twins, at least one of whom weighed 1250g or less at birth, and who both survived. All infants were scanned for germinalmatrix hemorrhage (GMH) and intraventricular hemorrhage (IVH). Of the 13 pairs, 11 were discordant for GMH/IVH. Among the 11 pairs, one pair included a child blinded by retinopathy who required special developmental tests; another pair was lost to follow-up after the second visit. The nine remaining discordant pairs received blind administrations of the Bayley Scales of Infant Development at 3, 6, 12, and 18 months corrected age (ie, age calculated from the maternal due date). The mean Bayley Mental Indices were:Thus, cases with a history of GMH/IVH fell progressively further behind their twins with negative scans; the discrepancy at 18 months corrected age was more than half a standard deviation (t = 3.35; p ≃ 0.01, two-tailed paired comparison).