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Granulosa cell desensitization: effects of gonadotropin on antral and preantral follicles.

The present studies examine the time course, hormonal specificity, and reversibility of gonadotropin-induced desensitization in rat granulosa cells in vivo and relate these events to changes in FSH and LH/hCG receptor availability. To these ends, desensitization to gonadotropins was compared in granulosa cells of preantral and antral follicles. Granulosa cells from antral follicles of estradiol- and FSH-primed hypophysectomized rats possess receptors for both FSH and LH/hCG. These cells appeared to exhibit heterologous desensitization of gonadotropin-stimulated cAMP accumulation in vivo; refractoriness initiated by either gonadotropin (5 μg human FSH or 5–50 IU hCG, administered iv) was communicated to both gonadotropin/adenylate cyclase response systems and prevented a secondary hormone-stimulated increase in cAMP accumulation. Heterologous desensitization was demonstrable within 120 min and occurred in the absence of detectable changes in the binding of 125I-labeled heterologous hormone to isolated gran...