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THE GENETICS OF AN EXPANDED SECRETOR SYSTEM

The genetics of salivary secretion of ABH blood group substance was investigated. Eight secretor phenotypes were determined by Sephadex G‐100 chromatography. Presence or absence of three different fractions were shown to be controlled by three different secretor gene loci. These loci are called Sec1, Sec2 and Sec3. Sec1 controls expression of the traditional secretor status. Sec2 and Sec3 are linked, but distinct, loci controlling the expression of low molecular weight ABH substance in human saliva. A dominant mode of inheritance for the Sec2 and Sec3 systems is described.