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On the Difficulties of Studying Pain Management in Individuals with Developmental Delay-Response.

Czarnecki et al. [1] are to be congratulated on attempting this prospective randomized controlled trial (RCT) to investigate what is undoubtedly a difficult medical problem and a difficult topic to study. RCT is frequently viewed as one of the most reliable methodologies and therefore among the highest levels of evidence when correctly conducted and interpreted. Although it is always disappointing when minimum recruitment targets are not met, the publication and careful interpretation of such data still adds to the contemporary knowledge base and may contribute to future analyses. Czarnecki et al. [1] found “no difference” in side effects, including RD, between their three groups, which might well have been expected given the small sample size and (thankfully) low incidence of this problem. Nevertheless, this is in accordance with our data.