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Genetics: Genome‐wide data processing for polygenic risk scores

Comprehensive genomic profiling in Alzheimer’s disease (AD) and other dementias will become pivotal in selecting targeted therapies based on an individual risk profile. The Genetics working group addresses this challenge by bringing together genetic data from over 25 cohorts to establish disease risk profiles using polygenic risk sores. Comparable work in other diseases, such as breast or prostate cancer, have shown enhanced utility for clinicians in predicting the development and progression of these diseases, by integrating polygenic risk scores into risk models. These links are, however, currently underexploited for clinical diagnostic practice in AD and dementia.