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Nigella sativa Extract and Thymoquinone Regulate Inflammatory Cytokine and TET-2 Expression in Endothelial Cells

Many natural compounds in particular flavonoids and polyphenols have been studied for their potential antiinflammatory actions. Nigella sativa (N. sativa) commonly known as black cumin is a spice, demonstrating anti-inflammatory, antidiabetic, antimicrobial and anticancer properties [1–3]. The spice is from the botanical Ranunculacea family and is found in North Africa, Southern Europe, India and the Middle East and has been used as herbal medicine in the treatment of several diseases including asthma, chronic headaches and skin disorders. Several compounds are present in Nigella seeds including Thymoquinone (TQ), thought to be its main active compound, as well as nigellicine, thymol and carvacol [4,5].