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Comparative evaluation of oral microflora adherence on modified tissue conditioners -- An in vitro study.

Aims: To evaluate the effect of silver nanoparticle, itraconazole and a
combination of the two agents on the adherence of Candia albicans,
Streptococcus mutans and Enterococcus faecalis on acrylic and silicone
tissue conditioners. Materials and Methods: 40 pellets of Group 1 ( GC
Soft Liner) and 40 of Group 2 (Sofreliner) were fabricated. The pellets
were immersed in a solution of silver nanoparticles or itraconazole or a
1:1 ratio of the combination of the two medicaments. The amount of
biofilm formed was assessed by the ELISA reader. Results: A decrease in
adherence of Candida albicans was seen in acrylic and silicone-based
tissue conditioners when compared to the untreated control samples.
Silicone based tissue conditioner showed the least adherence of Candida
albicans when treated with 1:1 ratio of silver nanoparticles and
itraconazole. There was a statistically significant difference in
microbial adhesion between acrylic and silicone tissue conditioner
(p<0.001).Pellets treated with silver nanoparticles were
studied for adherence of Streptococcus mutans , Candida albicans and
Enterococcus faecalis. A statistically significant decrease in all three
microbial adherences was observed with this group. (p<0.001)
Conclusion: Silver nanoparticles and itraconazole are effective
antifungal and antibacterial agents that can potentially decrease
microbial colonization of Candia albicans , Streptococcus mutans and
Enterococcus faecalis on tissue conditioners. Clinical implications:
Silver nanoparticles and itraconazole when used will decrease biofilm
formation that will not only improve the overall health of the oral
cavity but also prevent denture stomatitis and diseases associated with
poor oral hygiene protocols. Keywords: Silver nanoparticles, tissue
conditioners, itraconazole, antimicrobial.