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Editorial comment: life after transplantation.

Solid organ transplantation has come of age. The articles in this review highlight many of the advances in this challenging field and demonstrate how the successful development of this technique has transformed outcomes for many children dying of liver, bowel, renal, and heart disease. We are now confident that more than 80% of these children will survive to become teenagers and adults who will lead economically viable lives. Many issues remain related to early identification of rejection, ensuring long-term quality of life, reducing the adverse effects of immunosuppression, preventing chronic infection and rejection, and managing a smooth transition from childhood to adolescence and adult life.