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Differential expression of apoptosis receptors on diffuse and intestinal type stomach carcinoma

Intestinal and diffuse adenocarcinomas of the stomach differ in phenotypic properties, morphology, and growth behavior. Apoptosis (programmed cell death) is induced via specific cell‐surface receptors (SC‐1, Fas/APO‐1/CD95) and coregulated by intracellular molecules (bcl‐2, p53, etc.); the success of apoptotic processes is dependent on the expression of these signals. Differences in the expression of specific apoptosis receptors and intracellular‐related signals might help to explain the molecular pathogenesis of these two types of stomach adenocarcinoma.