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Genetics of Stimulation of in Vitro Hemolytic Plaque-Forming Cell Responses by Irradiated Allogeneic Spleen Cells


 The addition of heavily irradiated spleen cells to cultures containing syngeneic spleen cells and foreign erythrocytes may stimulate to some extent the hemolytic plaque-forming cell responses of those cultures, but the addition of allogeneic irradiated spleen cells may cause much greater stimulation. Irradiated spleen cells from mice of various inbred strains were tested for their ability to produce such stimulation in cultures containing spleen cells from an allogeneic or congenic resistant partner. It was found that a genetic difference in the region of the K end of the H-2 locus was sufficient to cause strong reciprocal stimulation, while a difference in the region of the D end was not. Multiple non-H-2 histocompatibility differences were ineffective, with two interesting exceptions. It is suggested that reciprocal allogeneic stimulation of in vitro hemolytic plaque-forming cell responses may be a useful means of detecting major histocompatibility differences. A model for allogeneic stimulation is proposed.