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A convenient approach towards biomimetic synthesis of zonarol and its related analogs

Labdane is a naturally occurring bicyclic diterpene. It forms the skeleton core for a large number of natural products. Several naturally occurring diterpenoids having decalin skeleton i.e, zonarol 1, warburgunal 2, and forskolin 3 show interesting biological activities such as anti-inflammatory properties and antioxidant effects. In view of their biological activities herein we are reporting our approach towards synthesis of the zonarol and its mimic derivatives by using commercially available α-ionone as starting material.