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Progress in astrocytes potassium channels and related diseases

Astrocytes are the largest number of glial cells in the central nervous system. In recent years,more attention has been paid to their role in the central nervous system. They not only serve as the ″soil″ for the survival of neurons by providing nutritional support,but also help clear glutamate,buffer potassium levels,and enhance immunity. The maintenance of astrocyte functions mainly depends on a variety of potassium ion channels,including the inward rectifier potassium channel( K ir),voltagedependent potassium channel( K v),ATP-sensitive potassium channels( K ATP) and two pore potassium channels. Potassium channels under physiological conditions are involved in regulating astrocytes.However,changes in the expression and functions of these channels under pathological conditions are closely related to pathogenesis of cerebral ischemia,epilepsy,Alzheimer disease and other diseases of the nervous system. This paper aims to review the research development on relationships between potassium channels in astrocytes and related diseases.