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How Low Can I Go? The Impact of Hypoglycemia on the Immature Brain

To the Editor .—

In a recent commentary in Pediatrics ,1 Inder discussed neonatal hypoglycemia and commented on an article by Burns et al2 that presented a diverse picture of hypoglycemia-related cerebral abnormalities found on neuroimaging in neonates. Dr Inder's review and cautions in extrapolation were sensible, but she concluded with a statement with which we strongly disagree: “… the experimental and human clinical data are clear that hypoglycemia (blood glucose level < 45 mg/dL), isolated or combined with …