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Inhibition by Neurotoxic Phospholipases A2 of Synaptosomal Uptake of γ‐Aminobutyric Acid

A comparison has been made of the abilities of several neurotoxic and nontoxic phospholipases A2 from snake venoms to inhibit the intake of γ‐aminobutyric acid into synaptosomes from rat cerebral cortex. The neurotoxic phospholipases A2 inhibited GABA uptake more than the nontoxic enzymes did. However, there was a poor correlation between the measured specific enzyme activity of a phospholipase A2 and its ability to inhibit the uptake of GABA.