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[GLA-protein of bone. Physiologic factor and new biological marker in bone pathology].

The gamma-carboxyglutamic acid-containing protein (GLA-protein) present in bone has strong affinity for hydroxyapatite crystals and its synthesis is vitamin D-dependent, which suggests that it might play a major role in bone physiology. It is also the first sensitive and specific marker of bone tissue remodelling. Usefulness of GLA-protein determinations in the diagnosis and therapeutic monitoring of bone diseases remains to be demonstrated by further studies.