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OC175: Comparison of endovaginal sonography (2D, 3D and Doppler) and MRI in the analysis of the myometrial involvement of endometrial carcinomas

Objective: To evaluate the ability of maternal characteristics, cervical length and uterine artery Doppler, performed during the second trimester, as screening test for spontaneous preterm delivery (SPD) in an unselected Chilean population. Methods: This is an ongoing prospective study involving 3401 asymptomatic women with a singleton pregnancies attending for routine antenatal care at the Hospital of University of Chile, who underwent standardized transvaginal scan at 22–25 weeks. Several variables, such as maternal characteristics, mean cervical length and uterine artery mean pulsatility index (PI), were studied using a logistic regression analysis as predictor of spontaneous delivery before 34 weeks. Results: The rate of SPD before 34 weeks gestation was 1.4%. Patients with SPD had significantly higher previous history of preterm delivery, shorter cervical length (31.6 ± 10.9 vs. 37.5 ± 5.7 mm) and higher mean PI of index in the uterine arteries (1.14 ± 0.41 vs. 0.98 ± 0.24) than controls. The detection rate at a fixed false-positive rate of 5%, was 28% for previous history of SPD alone, 41.2% for combined cervical length and previous SPD, and 52.9% when uterine artery Doppler was included in the model. Conclusion: Spontaneous preterm delivery is a complex syndrome but this study showed that a combined screening test can detect more than half of those patients destined to deliver earlier than 34 weeks of gestation. Supported by Fondecyt #1050482.