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Humoral hypercalcaemia in a patient with renal‐cell carcinoma

Abstract. In a patient with hypercalcaemia secondary to a renal‐cell carcinoma, a concentration gradient of bio‐activity was detected between the tumour effluent vein and the peripheral venous blood that was capable of stimulating adenylate cyclase in bone cells. Immuno‐reactive PTH was undetectable in the tumour effluent and in the peripheral blood. It is concluded that a non‐parathyroid humoral factor whose action involved cyclic AMP stimulation was responsible for the hypercalcaemia.