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Should molecular testing be required for diagnosing synovial sarcoma?

The t(X;18) translocation is a specific marker of synovial sarcomas (SS). Detection of SYT‐SSX transcripts by polymerase chain reaction (PCR) was tested on preselected specimens of well‐established histologic types, but to our knowledge, the diagnostic utility of molecular assays on a series of potential SS in comparison with conventional tools has never been reported.