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Tolerance of granulocyte donors towards granulocyte colony‐stimulating factor stimulation and of patients towards granulocyte transfusions: results of a multicentre study

Data of 507 granulocyte donations from 183 donors were evaluated. No severe granulocyte colony‐stimulating factor (G‐CSF)‐related side‐effects were observed. Three donors complained of severe itching following infusion of hydroxyethyl starch (HES). A high proportion (85%) of the donors stated that they would donate granulocytes again. The mean granulocyte yield was 4·3 × 1010. High‐molecular‐weight HES resulted in a significantly higher yield compared with low‐molecular‐weight HES. Mild, but no severe, adverse transfusion reactions were observed in 16% of the recipients. A leucocyte alloimmunization rate of 24% was found. G‐CSF stimulation and transfusion of G‐CSF‐mobilized granulocytes were well tolerated by donors and recipients, respectively.