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Salt dependence on vancomycin‐herbicide enantiomer binding: Capillary electrophoresis study and theoretical approach

In a previous paper, a mathematical model was developed for the estimation of binding constants by capillary electrophoresis (Guillaume and Peyrin, Anal. Chem. 1999, 71, 2046–2052). This model was applied to determinate the binding constant of the guest‐vancomycin complex as well as the degree of complexation nc (percent of complexed guest). In this work, the guest molecule were a series of acid herbicide enantiomers (aryloxypropionic, aryloxyphenoxypropionic, and aminopropionic acid). The effects of the run buffer salt concentration on the herbicide‐vancomycin binding was clearly described by the determination of specific physicochemical parameters as well as thermodynamic data. These results demonstrate that a better understanding of the interactions involved in the guest molecule‐vancomycin binding allows to optimize the enantiomeric separation of this chiral guest molecule.