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Histamine and the stomach: introduction.

The physiologic role of histamine in the stomach has for many years been a subject of controversy. The introduction of histamine-2-receptor antagonists and, later, of proton pump inhibitors has not only stimulated the interest in the topic but has also made it relevant for the clinician. The main and still unsettled issue is the interrelationship between histamine and gastrin on the parietal cell.