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Apoptosis is associated with atypical or malignant change in meningiomas. An in situ labelling and immunohistochemical study

Aims: Although necrosis is an important phenomenon with implications for grading and prognostication in meningiomas, the alternate form of cell death, apoptosis, has not been extensively studied. In this series, we aimed to determine whether apoptosis in meningiomas correlated with histological types and grading. We also looked for a relationship between expression of apoptosis‐related genes bcl‐2, p53, c‐myc and apoptosis in meningiomas.