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Effect of Aliskiren, a Direct Renin Inhibitor, on Macrophage Accumulation in a Rat Model of Pulmonary Fibrosis Induced by Fat Embolism

In a rat model of fat embolism using triolein (T), we have shown that the histopathological pulmonary effects of inflammation and fibrosis were reduced by administration of captopril and losartan treatment (1) and recently by the renin inhibitor aliskiren (2), underscoring the role of the Renin‐Angiotensin System in the pathogenesis of this condition. Aliskiren treatment also reduced the number of mast cells (MC) (3). In view of the known interactions of MC with macrophages in the inflammatory process leading to fibrosis, we extended our study to the lung macrophages.