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Studies on absorption, biotransformation and excretion of drug. II. Metabolism of 2-indanamine.

The metabolites of IA (2-indanamine hydrochloride) have been investigated in rats and rabbits. When IA (100mg/kg) was administered to rats, following metabolites were found together with unchanged IA:cis-, trans-1-hydroxy-2-indanamine, cis-, trans-1, 2-indandiol, 5-hydroxy-2-indanamine. In the urine of rabbits dosed 100mg/kg of IA, the presence of 2-indanol precursors of 2-indanone and was recognized together with the above metabolites. From the investigation about the sequence of metabolites of IA, it became evident that the oxidative deamination of IA was only occurred in rabbits, but not in rats.