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Preliminary Fluid Dynamic Studies of Accelerated Wear Testing on Bioprosthetic Heart Valves

Objective: For testing the fatigue of bioprosthetic heart valves (BHVs) in a timely manner, the U.S. Food and Drug Administration mandates that BHVs be tested with an accelerated wear tester (AWT), in accordance with ISO:5840. Due to the high frequency testing and the non-physiological conditions observed in AWTs, the mechanism of in vitro valve fatigue may not accurately predict the fatigue mechanisms experienced in vivo. Therefore, this study aims to quantify the fluid dynamics of AWTs with BHVs using high speed particle image velocimetry (HSPIV).