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PILOCARPINE‐INDUCED SUBSENSITIVITY TO CARBACHOL AND PILOCARPINE OF CILIARY MUSCLE IN VERVET AND CYNOMOLGUS MONKEYS

Vervet monkeys were given unilateral treatment for two weeks with one 2% pilocarpine eye drop three times daily between 8 a. m. and 6 p. m. (night interval 14 h) and were then subjected to anterior chamber perfusion. 20 μg pilocarpine intracamerally caused similar and substantial increases in outflow facility in both eyes. Cynomolgus monkeys were unilaterally treated with continuous release of 33 μg/h of pilocarpine for 5–6 days. The facility response to 1 mg/kg pilocarpine iv was small or absent on the treated side.