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The acetaldehyde content in rat brain during ethanol metabolism

ACETALDEHYDE, formed in the hepatic oxidation of ethanol, has been postulated to produce many of the effects observed after alcohol consumption (WALSH, 1971). One of these is the interaction between ethanol and the metabolism of biogenic amines in brain (TRUITT & WALSH, 1971). The competitive inhibition of aldehyde dehydrogenase by acetaldehyde may inhibit the oxidation of the aldehydes derived from different biogenic amines (LAHTI & MAJCHROWICZ, 1969; DAVIS, 1971) and cause an accumulation of pharmacologically active aldehydes (TABAKOFF et al., 1972). Condensation products with pharmacological activity formed by a direct reaction between acetaldehyde and biogenic amines have also been reported (COHEN, 1971). Moreover, acetaldehyde itself has a well documented indirect sympathomimetic effect (WALSH, 1971). Despite the importance of acetaldehyde in contributing to the effects of ethanol, there are only a few reports about acetaldehyde levels in the brain following ethanol administration (KIESSLING, 1962; RIDGE, 1963; DURITZ & TRUITT, 1966). The acetaldehyde levels found have been equal to or higher than the corresponding blood concentrations. This study investigates the acetaldehyde content in rat brain after the administration of a single dose of ethanol.