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Hypofibrinogenemia due to L-asparaginase: studies of fibrinogen survival using autologous 131-I-fibrinogen.

Plasma fibrinogen levels fall, often dramatically, in patients receiving L-asparaginase. Studies of six patients using autologous 131I-fibrinogen showed that at a dose of 1000 I.U./kg./day L-asparaginase had no effect on their rates of fibrinogen disappearance. The fall in their plasma fibrinogen levels, therefore, must have been a result of decreased synthesis since it could not be ascribed to increased utilization or destruction of fibrinogen.