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Breath methane in functional constipation: response to treatment with Ispaghula husk

Colonic fermentation produces hydrogen (H2), and also produces methane (CH4) in subjects with methanogenic flora (M+). Methane production has been associated with chronic constipation (CC) and with changes in gut motility. To determine CH4 production in CC compared to controls, and to assess whether the therapeutic response to Ispaghula husk in CC differs between CH4‐producers and non‐producers.