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Blood pressure and heart rate in parkinsonian patients with and without wearing‐off

Our study aimed to investigate the cardiovascular autonomic regulation related to the wearing‐off phenomenon in Parkinson's disease (PD). We measured blood pressure (BP) and heart rate (HR) at rest and during orthostatic test in 16 patients with PD with wearing‐off and in 15 patients with PD without wearing‐off both before (baseline) and repetitively at 1‐h intervals for up to 4 h after the morning PD medication dose.