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Changes in osteoporosis therapy in postmenopausal women from the RAC-OST-POL Study: a 10-year follow-up.

INTRODUCTION
The therapeutic regimens for osteoporosis are the key elements in the management of osteoporotic patients.


OBJECTIVE
The aim of the study was to present the data on changes in the therapy for osteoporosis in females during a 10-year follow-up.


PATIENTS AND METHODS
A population-based sample of the RAC-OST-POL Study provided the material for analysis. At baseline, the cohort included 978 women, out of whom, 541 women  remained at the follow-up observation, their mean age being 74.7 (SD 6.6) years.


RESULTS
The number of women without therapy and of those on alendronate decreased, while the number of patients, receiving other forms of the antiresorptive therapy or calcium/vitamin D supplementation increased. The percentage of untreated women in the rural areas and the urban areas was 85% and 74.1%, respectively at baseline and 74.3% and 63.3%, respectively. at the end of the follow-up period. The percentage of untreated women decreased significantly, both in rural and urban cohorts. It was accompanied by a significant increase of calcium/vitamin D supplementation in both subgroups. Regarding the antiresorptive therapy, there was a significant increase in the frequency of its use only in the rural cohort. The frequency of therapy strategies was determined by the level of education. The frequency of calcium and/or vitamin D supplementation increased significantly in all education categories during follow-up.


CONCLUSION
Changes in the therapy of postmenopausal women with osteoporosis, observed in a 10-year follow-up of postmenopausal women, indicated that the level of care of the postmenopausal women with osteoporosis did not improve.