{'fraction_non_alphanumeric': 0.02751196172248804, 'fraction_numerical': 0.016148325358851676, 'mean_word_length': 5.828571428571428, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Pre-treatment serum testosterone level can be a useful factor to predict the improvement in bladder outlet obstruction by tadalafil for male patients with lower urinary tract symptoms induced by benign prostatic obstruction

ABSTRACTIntroduction: To investigate possible pre-treatment factors related to the therapeutic effect oftadalafil on bladder outlet obstruction (BOO).Materials and methods: Eighty untreated outpatients with lower urinary tract symptoms (LUTS)due to BOO received 5mg tadalafil daily for 12months. Subjective symptoms and objective findingswere evaluated before and 12months after treatment. At 12months, the patients were dividedinto two groups according to an improvement grade in BOO index (BOOI). Patientcharacteristics including age, serum total testosterone level (TT), PSA, and prostate volume, andsubjective and objective parameters on LUTS were set as candidates of pre-treatment factors,and the parameters that influenced the improvement of BOO were statistically analysed.Results: A total of 69 patients with mean age of 69.8 years and mean prostate volume of48.8mL were included. Subjective symptoms and BOOI were significantly ameliorated after12months. In terms of an improvement of BOOI, 30 patients (43.5%) showed insignificantimprovement in BOO, whereas 39 patients (56.5%) exhibited excellent improvement.Comparison of pre-treatment factors between the groups showed that TT was the only independentpredictor related to the improvement in BOO. The improvement of BOO was significantlybetter in patients with higher TT.Conclusions: Pre-treatment TT was considered to be a useful predictor of therapeutic effects oftadalafil for BOO.