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CYROMAZINE‐SENSITIVE STAGES OF HOUSEFLY DEVELOPMENT: INFLUENCE OF PENETRATION, METABOLISM AND PERSISTENCE ON POTENCY

Cyromazine is a potent inhibitor of housefly (Musca domestica L.) larval development when administered orally to adults or incorporated into larval media, and of pupal metamorphosis on topical application shortly before or after pupariation. Pupae are most sensitive to cyromazine within 1 hr after pupariation and with tetrahydrofuran as the carrier solvent, giving topical LD50 values of 3 μg/g for the total puparium plus pupa and 0.2 μg/g calculated for the pupa only. Tetrahydrofuran is more effective than methanol in facilitating rapid cyromazine penetration during this critical pupal stage. The rate of cyromazine penetration or accumulation at sensitive stages appears to be more critical than the extent of metabolism in limiting cyromazine toxicity. Houseflies shortly after pupariation provide a sensitive and convenient organism for studies on cyromazine mode of action.