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In the Clinic-Tourette Syndrome: Deep Brain Stimulation Found to Improve Symptoms in Tourette Syndrome

In patients with Tourette syndrome, deep brain stimulation was found to improve symptoms, but also to have unfavorable side effects, a new study reported. Results of the prospective analysis involving a multinational cohort of patients were published online in the January 16 issue of JAMA Neurology. The International Deep Brain Stimulation Database and Registry, composed of 185 patients from 31 different institutions in 10 countries, found that the mean Yale Global Tic Severity Scale score improved 45.1 percent at one year after deep brain stimulation. The most common adverse events were dysarthria (6.3 percent) and paresthesias (8.2 percent). [For more data from the study, see “By the Numbers: Study Design, Results.”] “We’re logging all the cases as they come in from all over the world,” said Michael S. Okun, MD, FAAN, the report’s senior author and the Adelaide Lackner Professor and chair of neurology in the Fixel Center for Neurological Diseases at the University of Florida in Gainesville.