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Spectroscopic Studies Of The Stratum Corneum

Current spectroscopic investigations of thermally induced changes in the lipophilic pathway of the stratum corneum are beginning to provide insight into the molecular structure and barrier function of the stratum corneum. Enhanced permeability of lipophilic compounds has been noted between 37 and 70°C. Reversible solid to liquid transitions occur in the lipophilic pathway of the stratum corneum in the temperature region associated with enhanced permeability.