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Blockers of KV1.3 channel suppress smooth muscle response to injury and neointimal hyperplasia

In vascular injury, the mechanisms responsible for contractile smooth muscle phenotype is altered, leading to vascular smooth muscle cell (VSMC) proliferation and vascular diseases such as neointimal hyperplasia. Analysis of mouse VSMC mRNA revealed the selective upregulation of KCNA3 gene (encoding KV1.3) when the cells switch phenotype. We here provide evidence for its role in vascular proliferation.