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PP.LB03.17: CORRELATION AND MODIFICATION OF ARTERIAL BLOOD PRESSURE AND FLOW MEDIATED DILATATION (FMD) VALUES AFTER THE IMPLEMENTATION OF CPAP DEVICES IN PATIENTS SUFFERING FROM SLEEP APNEA

Objective: This study evaluates: 1) The presence of inflammation and vascular dysfunction in newly diagnosed patients with SAS without history of cardiovascular disease and 2) the effect of CPAP therapy on these disorders. Figure. No caption available. Design and method: 60 patients with clinical characteristics of possible SAS without history of cardiovascular disease were studied. All study subjects underwent sleep polysomnography. Evaluation of endothelial function was performed by measuring Flow Mediated Dilatation (FMD) in the brachial artery. Twenty three subjects had AHI below 5 and did not have SAS. Ten subjects with AHI between 5 and15 had mild SAS and received life style and dietary modification advice. Twenty seven subjects with AHI over 15 had moderate/severe SAS. These patients received CPAP therapy for 3 months and underwent follow up evaluation of FMD, and arterial blood pressure. Results: Patients suffering from mild or severe SAS had lower values of FMD in comparison with the values of the control group. With the use of CPAP the endothelial dysfunction improved (p < 0.01). On the contrary, CPAP therapy in normotensive patients did not significantly affect blood pressure levels (blood pressure levels were reduced by 2.5 mmHg in absolute values). Conclusions: According to the results of the study, endothelial dysfunction and systemic inflammation are present in newly diagnosed patients with moderate, or severe SAS without cardiovascular disease. Through the usage of CPAP, the endothelial dysfunction improved, having a positive impact on patients who are faced with an increased risk of cardiovascular disease. On the contrary, CPAP therapy in normotensive patients with SAS did not influence blood pressure levels statistically.