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Assessments of Onset and Duration of Drug Effects and Pharmacokinetics by Dose Level of HSK3486, a New Sedative-Hypnotic Agent, in Healthy Female/Male Subjects: A Phase I Multiarm Randomized Controlled Clinical Trial: Retraction.

The manuscript “Assessments of onset and duration of drug effects and pharmacokinetics by dose level of HSK3486, a new sedative-hypnotic agent, in healthy female/male subjects: A phase I multi-arm randomized controlled clinical trial” 1 There is evidence that the results are invalid as a result of a major error in the pharmacokinetic analysis. Specifically, the authors present two approaches to their pharmacokinetic analysis: a non-compartment and a compartmental approach. Although the title and abstract suggest this paper focuses on the pharmacokinetics of HSK3486, its hypothesis, primary outcomes, and secondary outcomes do not include a pharmacokinetic analysis. The pharmacokinetic analyses are presented in a supplement. The non-com-partmental analysis is reasonable; however, the non-compartmental analysis is not. The methods and results are inadequately described. The results report several elements that were either not mentioned or poorly described in the methods supplement.