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Preservation of endothelial cell/pericyte adhesion by cilostazol in ischemic limb of diabetic mouse

Purpose: Degeneration of pericytes and acellular capillaries are increased in the feet of human diabetic patients. Selective loss of adhesion of pericyte to endothelial cell is known to early event in diabetic microangiopathy. In diabetes, inflammation due to endothelial dysfunction is augmented. Cilostazol, a PDE III inhibitor, is reported to reduce inflammation and oxidative stress in diabetic patients. Based on these findings, we investigated the effect of cilostazol on endothelial/pericyte adhesion in ischemic hindlimb of diabetic mice.