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Sudden blast phase in pediatric chronic myeloid leukemia‐chronic phase with abnormal lymphoid blasts detected by flow cytometry at diagnosis: Can it be considered a warning sign?

Inconclusive knowledge persists regarding the course of chronic myeloid leukemia‐chronic phase (CML‐CP) patients with detectable abnormal blasts by flow‐cytometry at diagnosis. The 2016 WHO classification is not specific regarding sub‐classification of CML with <10% abnormal B‐lymphoid blasts (ABLB), and suggests these patients often show rapid progression. We report the clinical course of pediatric CML‐CP patients who had detectable abnormal blasts by flow‐cytometry at baseline.