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Immunostaining for thyroid transcription factor‐1 on fine‐needle aspiration specimens of lung tumors

Fine‐needle aspiration (FNA) is used commonly for the diagnosis of pulmonary neoplasms. It has been reported that thyroid transcription factor‐1 (TTF‐1) is a sensitive and specific marker for certain primary lung tumors. To the authors' knowledge, the use of TTF‐1 immunostaining on FNA smears has not been documented in the literature. This study was designed to examine the utility of TTF‐1 immunostaining on FNA specimens from various types of lung tumors by comparing the expression rates on Papanicolaou (Pap)‐stained and Diff‐Quik (DQ)‐stained smears with the expression rates on cell block (CB) sections.