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Expression of the DBA/2J Ren‐2 gene in the adrenal gland of transgenic mice.

To characterize further the tissue‐specific control of the mouse Ren‐2 gene, and in particular its expression in the adrenal gland, we have introduced the DBA/2 Ren‐2 gene into the genome of Ren‐1c/Ren‐1c mice. Here we report our observations on Ren‐2 transgenic mice. Expression was found in the correct spectrum of tissues and included appropriate hormonal control in the submandibular gland. Quantitatively transcript levels varied both positively (adrenal gland and sex‐accessory tissue) and negatively (submandibular gland and kidney) with respect to normal Ren‐2 expression. In the DBA/2 inbred mouse strain expression in the female adrenal gland cycles during oestrus between the X‐zone and the zona fasciculata. Transgene expression within the adrenal gland was restricted to the X‐zone. Therefore this phenotype, which is characteristic of most two‐renin‐gene strains of mice, contrasts with that found in the strain DBA/2 from which the transgene was derived. This suggests that cell‐specific expression in the DBA/2 adrenal gland is mediated in trans by at least one additional locus. We demonstrate that suitable genetic crosses of the transgenic mice can partially restore the cycling phenotype.