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Contrast and quantitative ultrasound mapping of heterogeneous Tumor function and structure

Tumor heterogeneity is associated with increased risk of therapeutic resistance and challenges evaluation of therapeutic response based on whole-tumor microvascular function or volume. To better interpret and relate ultrasonic maps of functional and structural properties in heterogeneous tumor, we compared matched regions of CEUS (Contrast-enhanced ultrasound) and QUS (Quantitative Ultrasound) maps with whole-slice, virtual histology sections stained for vascular and microstructural features.