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Optimum management of invasive cervical cancer in HIV/AIDS patients and impact on survival: Case series from a resource-limited setting and literature review

With the lengthening of life expectancy among HIV-positive subjects related to the use of highly active antiretroviral (HAART) treatments, an increased risk of cancer has been reported in this group of patients. The clinical management of cancers, including cervical cancer in HIV-positive patients has challenges mainly due to the concerns on immune status. At present, their mode of management is similar to HIV-seronegative patients and involves the use of chemotherapy and radiotherapy concurrently, as indicated. This becomes more challenging because HIV infection, cancer, radiotherapy, and chemotherapy lower immunity through reduction in CD4 cell counts, which is further complicated with low-resource setting of late presentation, poor access to HAART, lack of accessible radiotherapy facilities, and poverty.