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Noninvasive brain function measurement system: optical topography

Authors proposed optical topography to visualize the blood- volume change in the cortex associated with brain activation. The diffusion equation was used to obtain the sensitivity distribution of the blood-volume change. We show that the sensitivity distribution agrees with that obtained by the Monte-Carlo simulation. We then developed a phantom that simulates the light scattering property and brain activation in the cortex. Topographic images of the absorber in the phantom are obtained, and high location accuracy but spatial resolution of the topographic image were found. In addition, we derived a methodology to arrange optodes at high density in order to improve the spatial resolution of the topographic image.