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Genetic and Pharmacological Inhibition of OCT2 Protects Rats against Oxaliplatin‐Induced Peripheral Neuropathy

Colorectal cancer (CRC) is the third leading cause of cancer‐related mortalities in the United States. Oxaliplatin (OXPt) is widely used in the treatment of patients with CRC in both an adjuvant and metastatic setting; however, OXPt induces acute and chronic peripheral neuropathy (PN) in up to 90% of patients, characterized by paresthesia or sensory ataxia in the extremities. Previously, we identified organic cation transporter 2 (OCT2) as a contributor initiating OXPt‐induced PN in mice, and that pre‐treatment with the tyrosine kinase inhibitor, dasatinib, ameliorated acute and chronic forms of PN. Since the rat orthologue of OCT2 shares >90% sequence homology, we hypothesized that OCT2 inhibition can also afford protection in rats against OXPt‐induced PN.