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Evaluation of Coagulation with TEG in Patients Diagnosed COVID-19.

BACKGROUND AND AIM
A high D-dimer level may indicate the risk of coagulopathy and mortality in COVID-19 patients. Thromboelastography (TEG) is a test that evaluates clot formation and fibrinolysis in real-time, unlike routine coagulation tests. The study aimed to investigate the coagulation process with TEG in patients diagnosed with COVID-19.


MATERIALS AND METHODS
The study was performed at our university hospital, chest diseases outpatient clinic as a cross-section study. A total of 51 patients with 23 high D-dimer levels group (HDG) and 28 low D-dimers group (LDG) were included in the study. TEG analysis was performed at the pre-treatment evaluation in these two groups.


RESULTS
D-dimer and fibrinogen levels of the HDG were higher than those of the LDG (550 vs. 90 ng/mL, p<0.001; 521 vs. 269 mg/dL, p<0.001, respectively). In TEG analysis; HDG's R and K values were lower than LDG, and HDG's Angle, MA, and CI values were higher than LDG (respectively; p=0.037; p<0.001; p<0.001; p<0.001; p<0.001). ROC curve analysis suggested that the optimum TEG parameters cut-off points for thrombosis risk were as below: for K was ?2.1 min, for R was ?6.1 min, for Angle was >62°, MA was 60.4 mm.


CONCLUSION
Our study showed that the risk of thrombosis might increase in COVID-19 patients who are not hospitalized in the intensive care unit. Thrombosis risk should be investigated with TEG analysis and laboratory tests in every patient diagnosed with COVID-19, and treatment should be started for risky patients.