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Pharmacological retraining for T cells

Immune Regulation
Regulatory T cells (Tregs) expressing the Foxp3 transcription factor play a critical role in dampening overactive immune responses, including autoimmune diseases. Akamatsu et al. screened a library of small molecules and identified a compound that promotes Treg differentiation by inhibiting the cyclin-dependent kinases CDK8 and CDK19. The Treg-promoting activity of the CDK8/19 inhibitor reduced disease activity in mouse models of autoimmune diabetes and encephalomyelitis. CDK8/19 inhibitors are thus a new class of immunomodulatory drugs capable of generating Tregs with potential clinical applications in promoting tolerance and reducing autoimmunity.

Sci. Immunol. 4 , eaaw2707 (2019).