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Expression of HIF-1α, iNOS and COX-2 and its significance in gastric cancer

A I M : T o e x a m i n e a s s o c i a t i o n o f H I F - 1 α w i t h i N O S , C O X - 2 i n g a s t r i c c a n c e r a n d their relationship with tumor angiogenesis, clinicopathological feature and prognosis. METHODS: Immunohistochemical technique was used to detect expressions of HIF-1α and iNOS, COX-2 in 54 cases with gastric cancer. The association between HIF-1α expression with iNOS, COX-2 in tumor angiogenesis was analyzed, and clinicopathological features and prognosis of patients were investigated. RESULTS: The percentage of HIF-1α, iNOS and COX-2 protein positive expression was 74.07%, 66.67% and 62.9% in gastric cancer, respectively. The expressions of HIF-1α, iNOS and COX-2 were significantly higher in gastric cancer than in normal gastric tissue (P < 0.05). The expressions of HIF-1α, iNOS and COX-2 in gastric cancer were significantly associated with TNM stage, invasive depth and lymph node metastasis (P < 0.05) except for tumor grading. There were positive correlation among HIF-1α expression with iNOS, COX-2 (r = 0.596, r = 0.875, r = 0.502; all P < 0.05). CONCLUSION: HIF-1α and iNOS, COX-2 play very important roles in the development of gastric cancer. The over expression of HIF-1α induces tumor angiogenesis and invasion by activating the transcription of iNOS gene and COX-2 gene, thus joint detection is recommended for diagnosis of gastric cancer and estimation of prognosis.