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Cardiovascular Susceptibility in Offspring After Maternal Engineered Nanomaterial Exposure

Cardiovascular disease (CVD) is the leading cause of death worldwide and associated with many genetic and lifestyle risk factors. The maternal health and fetal milieu during gestation has been explored as a contributing factor to progeny health. Engineered nanomaterials (ENM) are manufactured within the nanoscale (<100 nm in one dimension) to take advantage of specific physiochemical properties. Exposure to these materials has become more prolific given their pervasiveness in domestic applications, yet the outcomes during pregnancy and for developing young are currently unknown. Gestational ENM exposure led to impairments in uterine microvascular reactivity in early studies, indicative of the development of a hostile gestational environment. The Barker Hypothesis theorizes that development is such an environment will influence cardiovascular health later in life.