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Treatment of advanced squamous‐cell carcinoma of the head and neck with a combination of cisplatin, vinblastine, and bleomycin

Fifty patients with advanced, measurable, squamous‐cell cancers of the head and neck received treatment with a combination of cisplatin, vinblastine, and bleomycin (PVB). The tumours in 25 patients (50%) responded to treatment (partially in 17 and completely in eight). The median duration of response was 18 weeks, and that of survival was 31 weeks. Toxicity was moderately severe; myelotoxicity occurred in 13 patients, and nausea and vomiting in 22 patients.