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Long‐term follow‐up of bone mineral density and bone metabolism in transsexuals treated with cross‐sex hormones

It is unknown whether long term cross‐sex hormone treatment affects the human skeleton. We monitored bone mineral density and biochemical markers of bone turnover for 28–63 months in 20 male‐to‐female transsexuals (M → F) treated with anti‐androgens and oestrogens, and 19 female‐to‐male transsexuals (F → M) treated with androgens. They underwent gonadectomy 13–35 months after the start of cross‐sex hormone administration.