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Impact of Mitochondrial DNA Haplogroups on Cancer Gene Expression

The objective of this study is to investigate the effects of mitochondrial (mt) DNA haplogroups on expression of cancer genes, and the role that mtDNA plays in retrograde signaling between the mitochondria and nucleus. The present study tests the hypothesis that mtDNA haplogroups (H versus K) can differentially modulate cancer gene expression through the STING (Stimulator of Interferon Genes) pathway in response to unique DNA fragments.