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Medicine and Books

Historically, immunology has always been intimately connected with microbiology, and the first immunologists were primarily concerned with problems of host resistance to infection. When interest in immunology expanded rapidly after the second world war investigators were preoccupied with characterising the mediators of immunological reactions and their cellular basis. Without this basis it would have been impossible to dissect the far more complicated problems of the host response to infections by various micro-organisms. More recently, there has been a resurgence of interest in immune responses to defined infections in man and experimental animals. To some extent this resurgence reflects the recognition that, while experiments including simple immunogens may be essential for dissecting immune mechanisms, these may give an unrealistic view of what happens in immune responses provoked by natural infections.