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Alterations of regional spontaneous neuronal activity and corresponding brain circuit changes during resting state in migraine without aura

Although previous resting‐state studies have reported abnormal functional cerebral changes in patients with migraine without aura (MwoA), few have focused on alterations in both regional spontaneous neuronal activity and corresponding brain circuits in MwoA patients during rest. Eighteen MwoA patients and 18 age‐ and gender‐matched healthy controls (HC) were recruited in the current study. Baseline cerebral alterations were investigated using amplitude of low‐frequency fluctuation (ALFF) and region of interest (ROI)‐based functional connectivity (FC) analyses. Compared with HC, MwoA patients showed decreased ALFF values in the left rostral anterior cingulate cortex (rACC) and bilateral prefrontal cortex (PFC) as well as increased ALFF values in the right thalamus. FC analysis also revealed abnormal FCs associated with these ROIs. In addition, ALFF values of the left rACC correlated with duration of disease in MwoA. Our findings could lead to a better understanding of intrinsic functional architecture of baseline brain activity in MwoA, providing both regional and brain circuit spontaneous neuronal activity properties. Copyright © 2013 John Wiley & Sons, Ltd.