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Sustained Hypoxic Pulmonary Hypertension and Systemic Vascular Dysfunction in High‐Altitude Dwellers Prone to Re‐Entry High Altitude Pulmonary Edema, Improvement by Anti‐Oxidants

Re‐entry high altitude pulmonary edema (HAPE) is a live‐threatening problem that occurs on return from low altitude in otherwise healthy high‐altitude dwellers. The underlying mechanism is poorly understood. Circumstantial data suggest that pulmonary vascular dysfunction facilitating hypoxic pulmonary vasoconstriction plays a role. There is increasing evidence that at in high altitude dwellers, pulmonary vascular dysfunction is often associated with alterations of the systemic circulation related to altered redox regulation. We speculated that re‐entry HAPE prone subjects display sustained pulmonary and systemic vascular dysfunction related to increased oxidative stress.