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Irregular Expression of the Intermediate Filament Protein in the Spinal Cord of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by an irreversible degeneration of motor neurons in the spinal cord, brain stem and cortex. The mechanism for the cause remains largely unknown. The goal of this study is to compare the protein expression in the spinal cord of the postmortem brains w/o ALS to understand the pathogenesis and mechanism of the disease.