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Lubricant Susceptibility of Cellactose and Avicel PH-200: A Quantitative Relationship

The lubricant susceptibility of two direct compression excipients, Avicel PH-200 and Cellactose, was determined using a model mix with metamizol sodium (dipyrone) and designed experiments to obtain a quantitative relationship by multiple regression. As a result, a new constant called specific lubricant sensibility Ls, is proposed for the comparison of lubricant susceptibility in other drug-excipient systems.