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Epileptic low-voltage fast-activity seizure-onset detector

In this paper, we present a seizure detector that is part of an implantable CMOS integrated device intended to identify seizure onsets and trigger focal treatment to disrupt seizure progression. The detector consists of a preamplifier, voltage level detectors, digital demodulators and a high-frequency detector. Variable gain amplification, adjustable threshold voltage identification and tunable recognition of high-frequency activities provide unique detection criteria for a specific patient. Moreover, digitally-controlled low-power CMOS circuits perform accurate seizure detection. A mathematical model of the seizure detection algorithm was validated in Matlab and circuits were implemented in a CMOS 0.18-µm process. Total power consumption of the detector is 6.71 µW. Detection performance was verified using intracerebral electroencephalographic recordings from a patient with epilepsy.