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Involvement of VDAC1 and Bcl‐2 family of proteins in VacA‐induced cytochrome c release and apoptosis of gastric epithelial carcinoma cells

OBJECTIVE:  It is known that the vacuolating cytotoxin (VacA) could induce apoptosis. However, the mechanism remained to be elucidated. The aim of this study is to investigate the role of Bcl family of proteins (Bcl‐2 and Bax) and the mitochondrial voltage‐dependent anion channel (VDAC) in VacA‐induced apoptosis of AGS cells.