{'fraction_non_alphanumeric': 0.02696629213483146, 'fraction_numerical': 0.011235955056179775, 'mean_word_length': 5.801526717557252, 'pattern_counts': {'":': 0, '<': 2, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Is paracetamol as effective as indomethacin or ibuprofen in closing a hemodynamically significant patent ductus arteriosus in preterm infants?

This study was a prospective, randomized trial comparing paracetamol to indomethacin and ibuprofen for closing a hemodynamically significant patent ductus arteriosus (hs-PDA) in premature neonates (<28 weeks GA or <1500 grams). Currently available treatments to close the PDA include indomethacin and ibuprofen, but these treatments have been associated with transient reduction in kidney function (1,2), and they are contraindicated in patients with active bleeding or renal dysfunction. Surgical ligation of the PDA has been associated with worse neurodevelopmental outcomes and BPD (3), although there may be no difference in outcomes after correcting for perinatal confounders (4). This article is protected by copyright. All rights reserved.