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The central control of the lumbar sympathetic pathway to the large intestine of the cat.

1. The origin of the lumbar sympathetic inhibitory outflow to the large intestine was studied by recording simultaneously changes in colonic motility and efferent firing in the lumbar colonic nerves (l.c.n.) following lesions at various levels of the neuraxis. 2. Multiunit recordings from the l.c.n. usually consisted of irregular grouped discharges which were unrelated to spontaneous colonic contractions or to respiratory or cardiac cycles. The firing was depressed by the administration of ganglionic blocking agents or by decentralization of the inferior mesenteric ganglion, indicating that it was post‐ganglionic and primarily central in origin. 3. In the majority of experiments colonic motility and l.c.n. firing were not altered by transection of the cervical (C2‐C3) or thoracic (T10‐T13) spinal cord. However, in these acute spinal animals destruction of the lumbar ventral roots or the lumbar spinal cord markedly enhanced colonic motility and depressed l.c.n. firing. These findings indicate supraspinal mechanisms are not essential for the generation of the lumbar inhibitory outflow to the colon. 4. Transection of the l.c.n. enhanced colonic motility in animals with an intact neuraxis, in acute spinal animals and in animals where the thoracolumbar sympathetic outflow was blocked. It is concluded that peripheral ganglionic as well as spinal pathways can sustain an inhibitory input to the colon. 5. L.c.n. firing was enchanced by stretching or pinching the proximal colon or small intestine or by electrical stimulation of intestinal afferent fibres (Adelta and C fibres) in the l.c.m. and mesenteric branches of the splanchnic nerves. The reflexes occurred via spinal pathways and were blocked by transection of the lumbar dorsal roots. Spontaneous firing in the l.c.n. was also generated by isolated segments of the lumbar spinal cord; however, this firing occurred independently of traditional reflex pathways since it was uanffected by transection of the lumbar dorsal roots. It is concluded that the spontaneous firing must be generated via ventral root afferent pathways or via endogenous oscillator circuits in the lumbar spinal cord.