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Sodium homeostasis in the newborn and low-birth-weight infant.

Sodium homeostatic mechanisms and clinical disturbances in the VLBW infant have been reviewed. Attention has been given to the unique natriuresis experienced to the greatest degree by the smallest and most ill infants reflecting unique differences in renal and neuroendocrine mechanisms. The precise requirement for sodium in relation to protein feeding practices may not yet be fully elucidated and will require further clinical evaluation.