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Mechanism of Phenytoin Action at the Cellular Level

The mechanism of phenytoin (PHT) action has been studied extensively by various investigators. Most of their conclusions can be summarized by 1) inhibition of the sodium channel in the excitable membrane, 2) inhibition of the calcium action related to neuronal excitation and 3) inhibition of cellular phosphorylation. They are all based on the inhibitory action on excitability of the normally functioning neurons.I* The mechanism of action of PHT has seldom been studied with respect to intracellular events. We described our experiments at the cellular level, and discuss the mechanism of PHT action.