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Successful treatment of acquired cutis laxa with urticarial eruption by diphenyl sulfone

Cutis laxa (CL) is a rare disease, characterized by a progressive skin loosening and defects in other organs that contain elastic tissue. Patients with CL present with wrinkled, sagging and inelastic skin. The disease is classified into congenital and acquired CL (including Types 1 and 2).Type 1 acquired CL commonly begins in adulthood, and is characterized by skin laxity preceded by an inflammatory phase of erythematous plaques.We report a case of generalized acquired CL presenting with pruritic urticarial plaques. A 29-year-old woman presented with a 2-year history of gradually developing, severe, cosmetically disabling, wrinkling of the skin all over her body. At onset, she had also experienced recurrent urticaria of unknown causes all over her body, and later, multiple, asymptomatic, urticaria-like papules and plaques