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Contraceptive treatment with chlormadinone and its effect on the endometrium. A histological investigation.


 To study the effectiveness of chlormadinone acetate as an oral contraceptive and its effect on the endometrium, 42 women took .5 mg of chlormadinone acetate daily for a total of 424 cycles. 19 patients became pregnant and represent Group 1, while 18 patients with constant cycles were identified as Group 2. Histological investigations of Group 1 revealed abnormal decidual and placental structures in 17 of the 19 women in this group. Group 2 was studied for the effect of luteal supplementation on the endometrium. Mucosa patterns showed numerous deviations from the normal pattern. Investigations into the endometrium showed chlormadinone to be a cause of disturbance in the endometrium, whereby normal placentation is checked to a greater extent than nidation. This would appear to be supported by a number of pathological findings in the fetal membranes of Group 1.
