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Design of melt-recyclable poly(ε-caprolactone)-based supramolecular shape-memory nanocomposites

A novel poly(epsilon-caprolactone) (PCL) supramolecular network exhibiting shape-memory behavior was successfully constructed with pendant UPy units that are highly able to dimerize. The dynamic network was obtained by a simple and versatile strategy consisting of chain-extension reaction between α,ω-dihydroxyoligoPCL and hydroxylated UPy units in the presence of hexamethylene diisocyanate as a coupling agent and further intermolecular dimerization of the UPy along the polyurethane backbone. 1H NMR analyses confirmed the dynamic features of the system, and DMTA in tensile mode was investigated to assess the SMP properties. Recyclability was also assessed by taking advantage of these supramolecular networks. Further addition of cellulose nanocrystals into the polymer network enabled adjustment of the extent of the net-points and therefore the SMP features. As confirmed by dispersion tests in solution and SEM observations, these bio-based nanofillers were homogeneously distributed in the network via supramolecular interaction between the hydroxyl groups present on their surface and UPy moieties along the polyurethane backbone. Thus, the here developed nanomaterials might reveal applicability in areas where a combination of SMP and biocompatibility is needed.

(1) Introduction Shape-Memory Polymers (SMPs) have been gaining great interest as a new class of stimuli-responsive materials for 30 years due to their high elastic deformation, low density, relatively low cost, easy processing, high recoverable strain within a large range of stimuli and chemical stability as well as potential applications ranging from biomedical materials to engineering thermoplastics. 1 These polymeric materials can be xed into a metastable shape and, subjected to an external stimulus such as variation in temperature, light, magnetic eld and water or solvent immersion, will recover their original shape. 2,3 The most common SMPs, i.e., dual-shape heatingresponsive SMPs, are built on a network architecture composed of permanent and switching domains: they combine chemical or physical covalent crosslinks dening the permanent domain, and switching domains associated with a transition temperature T trans (glass temperature (T g ) or melting temperature (T m )). In this case, the deformed temporary shapes are stabilized by a cooling step below the T trans and the polymer chains are quenched in a stressed state. A subsequent heating above the T trans allows for entropic relaxation of the freezed macromolecular chains, leading to permanent shape recovery. Interestingly, some semi-crystalline polymers also display an exciting reversible elongation-induced crystallization in the presence or in the absence of an external stress, 4 resulting in SMPs with reversible properties, i.e., the two-way SMPs. However, in the case of irreversibly cross-linked semicrystalline materials, the crystalline features of the resulting network (T m , crystallinity degree and crystallization rate) are depressed compared to the precursor linear material due to the reduction of the molecular motion and crystal growth. [5][6][7] Over the last years, the use of dynamic (reversible) covalent and supramolecular polymer networks has emerged as an alternative option for the SMP design due to their triggable and reversible nature. 8 Indeed, the ability to form, to break and to subsequently reform a specic bond or interaction upon an external stimulus has appeared as a great opportunity to tune SMP architectures. The presence of reversible binding groups in SMPs ensures the stabilization of the temporary shapes, imparts recyclability properties, enables alternative nonthermal triggers for the switching mechanism or engenders extra functionality like self-healing. 9 Whether these groups are covalent or supramolecular in nature, they can serve as either permanent or temporary net-points. One of the most illustrating dynamic covalent groups used in SMP design are the thermoreversible Diels-Alder (DA) adducts, e.g., the furanmaleimide DA adducts. While the [4+2] cycloaddition proceeds at room temperature, the reverse reaction (retro-DA) becomes generally favorable above 100 C. The shape reprogramming of some SMPs based on biodegradable polymers such as poly(3-caprolactone) (PCL) and poly(lactide) (PLA) as the switching domain was allowed by the presence of such DA adducts as widely reported in the literature. 5,10-16 Simultaneously, relevant non-covalent interactions such as hydrogen bonding, 17-20 metal-ligand coordination, 8,21 ionic interactions [22][23][24] or p-p stacking 25 were integrated into SMP designing. Among this wide variety of supramolecular interactions, the hydrogen bonds have acquired a specic attention to build reversible polymeric materials, being able to display SMP properties. 17,26,27 In 1997, Meijer and co-workers revealed that the self-complementarity hydrogen bonding arrays of 2-ureido-4-pyrimidone (UPy) end groups in linear polymers allowed obtaining thermodynamically controlled self-assembling architectures. 28 Thanks to the strong dimerization of the UPy units (dimerization constant greater than 10 6-7 M À1 in chloroform) and a predictable tautomerization, 29-32 polymers displaying a high degree of polymerization could be easily obtained. 33,34 In addition, the UPy functional groups are also present as dimers in the solid state via a donor-donor-acceptor-acceptor (DDAA) array. 32 In this context, the quadruple hydrogen bonding motifs of UPy molecules have been then employed to design SMPs. 9 As the hydrogen bonding is highly-reversible and strongly temperature dependent, 35 UPy groups were rst used as molecular switches 36 exhibiting excellent shape memory effect (SME), related to the temperature dependence of the hydrogen bonding dynamics. Interestingly, the presence of UPy groups as pendant groups in a chemically cross-linked acrylic copolymer afforded the material to change shapes twice and to x two metastable temporary shapes. The triple-shape capability resulted from the polymer T g and the dissociation of selfcomplementarity hydrogen as the two molecular switches. 37 Using novel approaches, it was also demonstrated that UPy moieties could be imparted into SMPs to support the stabilization of the permanent shape. Interestingly, Xiao et al. developed a one-step procedure to create UPy-functionalized poly(3caprolactone)/poly(para-dioxanone) (PPDO) interpenetrated polymer networks (IPNs) with triple shape ability. A covalent cross-linking was established between PPDO and hexamethylene diisocyanate and a supramolecular network was formed through self-complementarity hydrogen bonds between the UPy end-groups of the star-shaped PCL. 38 A PCL-PPDO covalently cross-linked network was prepared for comparison. In the new covalent IPN network, the ability of each polymer segment to achieve crystalline phase was greater compared to this star-shape covalently PCL-PPDO network and the resulting t-SME was excellent. In a further work, a dynamic network was produced via the self-complementarity quadruple hydrogen bonding through the UPy-poly(tetramethylene ether)glycol and 4-UPy star-shaped PCL. 39 Besides the t-SME ensured by the presence of two separated T m and the UPy dimer net-points, the material exhibited a good self-healing feature due to the reversibility of the dynamic network. Recently, supramolecular poly(vinyl alcohol) (PVA) networks were prepared through the dimerization of UPy motifs into the macromolecular chains by Chen et al. 40 In this particular work, the PVA chains acted as thermo-reversible phase, whereas the presence of UPy dimers formed "cross-linked" net-points, ensuring the xation of the permanent shape. In addition to the direct thermally triggered recovery, water-induced recovery was observed when the samples were immersed because of the plasticizing effect of the water molecules decreasing the polymer T g . Thereby, it was proven that conventional chemical covalent cross-linked bonds might be potentially replaced by quadruple hydrogen bonding of UPy arrays to easily obtained functional materials.
In the present work, we herein describe the design of new supramolecular shape-memory polymeric networks made of semi-crystalline PCL oligoester segments, as switching domains, and UPy unit pendant side-groups, as permanent domain. In contrast to Chen et al., 40 we report a exible pathway to readily incorporate UPy units with hydroxyl functionalities (UPy(OH) 2 ) in a,u-dihydroxy PCL-oligomers through coupling reactions. Indeed, due to their biodegradability, biocompatibility and low melting temperature, PCL oligomers indeed represent promising candidates for new bio-applicative SMPs. 41 Practically, the synthesis of UPy(OH) 2 was rst developed and following polyurethanes (PUs) from commercial oligoPCL and UPy(OH) 2 were obtained by chain-extension reaction in dimethylformamide (DMF) at 80 C in the presence of hexamethylene diisocyanate (HMDI) as coupling agent (1.1 equivalents relative to OH) and dibutyltin dilaurate (DBTL) as catalyst. To control the density of supramolecular net-points, and therefore of the xing domain, cellulose nanocrystals (CNCs) were added into the PUs networks. Interestingly, cellulose nanocrystals have been considered as a compatible reinforcing nanomaterial for diverse biopolymers. 42 They are abundantly produced from renewable resources and offer several advantages such as stiffness, biocompatibility, low density, low cost, high aspect ratio. 43 High modulus and interconnected CNCs networks could be formed in polymer matrix containing polar group or hydroxyl end-functionality (e.g., PLA, PEG) via hydrogen bonding due to the presence of abundant hydroxyl groups on their surface. 3 Moreover, UPy-functionalized CNCs are utilized as llers in a UPy-modied telechelic building block for the design of light-healable supramolecular nanocomposites. 44,45 In the present study, the advantage is taken from the presence of free hydroxy groups on the neat (unmod-ied) CNCs surface and their interactions with UPy in order to nely dispersed them into PU materials as to reinforce the supramolecular networks with additional hydrogen bondings.
UPy(OH) 2 was obtained aer three successive reaction steps. The two rst intermediate products were obtained as reported earlier. 39 First, a suspension of guanidine carbonate (25.48 g, 0.198 mol) and EAA (16.2 g, 0.18 mol) in ethanol (200 mL) was reuxed for 8 h. The resulting white mixture was ltered on a Buchner funnel and then washed in ethanol, deionized water and acetone, successively. 6-Methylisocytosine (MIC) was nally obtained aer further drying in vacuum oven overnight (yield ¼ 74%). In the second step, MIC (15.0 g, 0.12 mol) was dissolved in HMDI (143 mL, 0.888 mol) under nitrogen ow and the reaction was conducted at 100 C for 12 h. Aer cooling, the mixture got precipitated and washed with petroleum ether and then dried under vacuum. 1-(6-Isocyanate)-3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)urea (UPy-NCO) was recovered with high yield (98%). Finally, UPy-NCO (15.0 g, 51.2 mmol), AMPD (8.06 g, 76.8 mmol) and 450 mL of dry chloroform were added into a round-bottom ask under nitrogen atmosphere and heated at 60 C for 6 h. Aer ltration of the mixture on a Buchner funnel, the recovered white powder was then dissolved into 240 mL of DMF. A following centrifugation step eliminated the by-products and the supernatant was poured into 1.5 L of ether absolute. The precipitate was recovered by ltration under vacuum. Aer washing with acetone, UPy(OH) 2 was dried overnight at 40 C with a yield of 86%. 1 H NMR spectra in DMSO-d 6 of MIC, UPy-NCO and UPy(OH) 2 are showed in ESI (see Fig. S1, S2 and S3, † respectively).

(2.3) Synthesis of PUs
PCL(OH) 2 and UPy(OH) 2 were rst introduced in a previously ame-dried round-bottom ask and dried 1 h under vacuum. Then, between 20 and 25 mL of anhydrous DMF were added under nitrogen ow. The solution was heated up to 60 C until its complete dissolution. HMDI and DTBL were successively introduced under nitrogen ow. All syntheses were conducted at 90 C under nitrogen ow for 6 h. Aer reaction, mixtures were injected into a horizontal Teon mold in a glass autoclave to evaporate the solvent for 24 h. The resultant lms were rst transferred into a drying oven overnight at 60 C and put under vacuum for 24 h at 40 C. CNCs were prepared from ramie bers as reported in the literature. 46 Briey, 60 g of puried ramie bers were cut into small pieces and treated with 1000 mL of a 4% NaOH solution at 80 C for 2 h to remove residual contaminants. The bers were then submitted to acid-hydrolysis with 800 mL of sulfuric acid solution (65% wt) at 55 C for 30 min and under continuous mechanical stirring. The obtained suspension was ltered through a sintered glass no. 1 to remove macroscopic fragments from unhydrolyzed bers. The suspension was thoroughly washed with water by centrifugation and dialyzed against deionized water until neutrality. The suspension was concentrated to 4% wt and constituted the stock suspension. The resulting CNCs display an average length around 200 nm and an average width of 7-10 nm according to TEM analyses.
Dispersion of CNC in DMF. An aqueous suspension of CNCs was solvent-exchanged from water to DMF. 10 g of DMF was added to 10 g of the aqueous dispersion of CNCs, then the mixture was transferred to a 100 mL ask and water was evaporated using rotavapor. Finally, the suspension was ultrasonicated for 5 min to re-disperse the CNCs. The concentration of the nal suspension was determined gravimetrically to be 3.7% wt.

(2.5) Preparation of nanocomposites
First, the suspension of CNCs in DMF was ultrasonicated for 10 minutes. Meanwhile, a specied amount of PU was solubilized in 10 mL of DMF. Then, both mixtures were put together and mixed overnight. Solution was ultrasonicated for 15 minutes. Films containing 2.5, 5, 10 and 15 wt% of nanoparticles were obtained by casting the mixtures in a Teon mold and drying in a glass autoclave at 80 C for 24 h. Resulting lms were placed in a vacuum oven at 40 C for a few hours. To carry out DMTA analyses and to homogenize the thickness, lms were hotpressed at 110 C.
(2.6) Characterization techniques 1 H NMR spectra were recorded with Bruker AV400 spectrometers (Bruker, Germany) at 400 MHz in DMSO-d 6 and CDCl 3 using TMS as an internal reference. Size-exclusion chromatography was performed on a Waters apparatus equipped with a model 1515 pump, a Waters model 717 autosampler and a 2414 refractive index detector, using monodispersed polystyrene standards to get a calibration curve. The elution solvent was chloroform at a ow rate of 1.0 mL min À1 at 30 C. The sample concentration was about 2.5 mg mL À1 . ATR Fouriertransform infrared (FTIR) spectra were recorded using Bruker Tensor 17 spectrometer. Thermal properties of precursors and PUs were determined by DSC measurements using a DSC Q200 from TA Instruments under an ultra-high purity nitrogen ow. The following "heat/cool/heat" procedure was applied to all samples: rst heating to 200 C (10 C min À1 ) in order to erase the thermal history of samples, cooling to À80 C (10 C min À1 ), followed by a second heating to 200 C (10 C min À1 ). Sample weights were generally in the range of 5-10 mg. The thermomechanical properties of the PUs and their nanocomposites were tested with a DMA Q800 apparatus from TA Instruments in a multi-frequency strain mode (tension mode). Samples were heated at 3 C min À1 from À80 to 70 C at a frequency of 1 Hz with an oscillation amplitude of 10 mm and a force track of 125%. The morphology of the samples was observed using a scanning electron microscope (SEM) (JSM-5900LV, Jeol Co., JP). The observed cross-section was prepared by fracturing the samples in liquid nitrogen. The accelerating voltage was 20.0 kV and magnication level was comprised between 2000 and 80 000Â. Rheological measurements were performed using a ARES Rheometer from Rheometrics. Cone and plate geometry (diameter 25 mm) was used to register the viscoelastic response. Strain sweep measurements were rst performed at 110 C with a frequency of 1 Hz. Then, frequency sweep measurements were recorded in linear regime conditions at a temperature of 110 C with a strain of 10%. One-way shapememory properties were determined using the Q800 apparatus in stress-controlled mode on rectangular specimens of approximately 15 mm Â 5 mm Â 0.30 mm cut from hot-pressed lms. Note that for each sample, a heating ramp (5 C min À1 ) and a cooling ramp (3 C min À1 ) were successively applied in order to limit the variation of strain at high temperature. The typical four-step program was applied to determine the one-way behavior: (a) apply of a given load at a temperature higher than the second T m of PU system (T ¼ 100 C) to stretch the sample; (b) cooling in two steps to 60 C and then to 0 C (10 min-isotherm) at 2 C min À1 to x the temporary shape; (c) quick unloading; (d) nal heating to 95 C at 3 C min À1 followed by a 10 min isotherm to let the sample recovered to its initial shape. The one-way SME was characterized by the shape xity ratio R f , representing the ability to maintain temporary shape and by shape recovery ratio R r which shows the extent of the recovery, dened as followed: where 3 un is the strain aer cooling and unloading, 3 max is the strain obtained before the constant loading was released and 3 n is the strain obtained aer heating in the step of recovery.

3.1) Synthesis and characterization of PCL-UPy polyurethanes
Three PCL-based PUs with different UPy pendant motifs (30, 50 and 70 mol% according to Table 1) were obtained via a chainextension reaction between commercial a,u-diol PCL oligomer, UPy-diol monomer and 1,6-hexamethylene diisocyanate (HMDI) as coupling agent performed in dry DMF (Scheme 1(A)). Solution version of the coupling reaction was here preferred to reactive extrusion in order to maintain linearity of the polyurethane chains and avoid undesirable side reactions such as any crosslinking. FTIR analysis of the products (Fig. 1) presented barely visible band around 2200-2300 cm À1 assigned to unreacted isocyanate (-N]C]O) functionality and a large band around 3300 cm À1 ascribed to the presence of hydrogen bonds, mainly originating from dimerization of UPy moieties (i.e., four hydrogen bonds per dimer, Scheme 1(B)). 47 However, hydrogen bonding between PUs chains or PUs and UPy (carbonyl group of urethane bond or the ester moieties along the PCL backbone and -NH moieties) cannot be neglected. These hydrogen bonds usually trigger a poor solubility of PUs materials in common solvents 48 Interestingly, the UPy enriched PUs synthesized herein were readily soluble in chloroform upon a vigorous stirring for one hour, thus allowing to monitor the chain-extension reaction by SEC and 1 H NMR. Though the molecular parameters recorded by SEC must be considered with precaution, it comes out that M n of the different PUs increases with PCL content ( Table 1), proving that chain-extension is taking place. In addition, the 1 H NMR spectrum of PU (1) as illustrating example reveals the absence of the peak at 3.65 ppm respective to end-chain group of PCL (-CH 2 -OH), and shows down eld signals at d ¼ 13.14, 11.77 and 9.95 ppm (Fig. 2(A)), assigned to UPy-based intermolecular hydrogen bonds. 30 In comparison, chemical shis for polyester-polyurethane H-bonds, expected to occur at d ¼ 9.95, 9.76, 9.68 and 8.66 ppm (ref. 45) are not observed.
The presence of a pyrimidyl resonance peak at 5.84 ppm (proton "h") showed that the UPy dimers adopted ketotautomeric form within the PU structure. 30 1 H NMR of PU (1) was also recorded in DMSO-d 6 . This strong hydrogen bond  Paper acceptor solvent disrupted the dimerization of the UPy groups and the NH signals shied to d ¼ 11.7, 10.2 and 7.7 ppm (blue spectrum in Fig. 2(B)). Thus, combining FTIR and 1 H NMR measurements tends to conrm the presence of UPy inter-chain hydrogen bonds both in solvent like CHCl 3 and in bulk state.
Thermal, mechanical, SME and recyclability investigations. Once the molecular structure of the PUs had been conrmed, their thermal behavior was studied by DSC and the thermal characteristics (melting temperature and melting enthalpy) are reported in the Table 1. As might be seen, a T m ranging from 44 C to 51 C was recorded, indicating that the crystalline properties of the neat PCL were maintained in the design of supramolecular networks. The melting enthalpies (DH m ) of PCL in PUs decreased with UPy molar content (from 53.50 J g À1 to 33.69 J g À1 for PU (2) and PU (3), respectively), suggesting that chain extension slows the crystallization of PUs, most probably due to hydrogen bonds formation, as shown earlier for poly(tetramethylene ether glycol)-UPy systems. 47 Indeed, the dimerization of the pendant UPy groups might be expected to form a supramolecular network that would decrease the PCL chains mobility, restrict their arrangement at the juncture and thus lower the crystallization. This hypothesis was somehow supported by the thermo-mechanical properties and rheology evaluations (see ESI †).
With this respect, relatively poor PU (3) and PU (2) mechanical resistance was clearly evidenced and ascribed to the lack of sufficient supramolecular network formation, related to the low amount of UPy functions present within these materials. Thus, only PU (1) was considered as a potential candidate for SMP (Fig. 3 le). As shown on the strain-stress-temperature curve, PU (1) was deformed to 110% of elongation by a constant load (s app ) of 0.18 MPa maintained during the cooling to 0 C.   Aer stress release, the temporary shape was xed with a R f value of 100%. Aer a second heating to 60 C, the nal shape was recovered to a residual elongation of 30% corresponding to a R r of 73%. Like the PVA-based supramolecular network developed by Chen et al., 40 our PCL-based supramolecular network exhibits a good heating-responsive SME with an excellent R f and suitable R r . However, chemically cross-linked SMPs, even though displaying excellent SME, generally suffer from a lack of recyclability and/or processability. As in the case of PU (1) the SMP was crosslinked by hydrogen bonding with dynamics depending on temperature, recyclability of the material was expected. For  conrming this hypothesis, PU (1) was chunked into pieces, and regenerated into a new lm by compression molding at 110 C for 10 minutes and SME was evaluated. Indeed, as shown in Fig. 3 (right), the new specimen also exhibited excellent shapememory properties with a complete shape xation (R f ¼ 100%) and a R r value of 67%. Moreover, this behavior is repeatable, meaning that our supramolecular networks are easily reprocessable and maintain SME properties.

(3.2) PCL-UPy-CNC nanocomposites
In an attempt to further improve thermal and mechanical properties of the supramolecular PU (1) network, CNCs were selected as suitable biocompatible nanollers able to complement the network due the hydroxyl groups present on their surface (Fig. 4). Indeed, CNCs are known to promote microphase separation between so and hard segments in PCL-based water borne polyurethanes and inuence both glass transition temperature (T g ) and crystallinity of the polyester. 49 Moreover, the Young's modulus and the tensile strength increased with the CNC content due to the formation of three-dimensional network of hydrogen-bonding inter-actions between CNC particles and between CNC and WPU matrix.
Here below, PCL-UPy-CNCs nanocomposites were prepared by mixing in DMF solution the CNCs suspension and the previously solubilized PU (1), followed by a subsequent sonication. Nanocomposite lms containing 2.5, 5, 10 and 15 wt% CNCs were then obtained by solvent casting.
CNC dispersability and PCL-UPy-CNC microstructure. In order to highlight the CNCs dispersion ability into the PCL hydrophobic matrix and the hydrogen bonding, a rst visual dispersion test was carried out in CHCl 3 as a bad dispersant for CNCs. 50 For this, PCL-UPy-CNCs nanocomposites strips of approximatively 50 mg were swollen in 10 mL of CHCl 3 at room temperature and upon a long-time vigorous mixing the stripes completely dissolved and the mixture became hazy (Fig. 5(A)). The resulting dispersions remained stable over a week, with no macroscopic CNCs aggregation and/or sedimentation. In comparison, a PU made only of PCL and HMDI and containing 15 wt% CNCs showed a dramatic aggregation of CNCs dispersion with complete CNCs sedimentation in just a few minutes ( Fig. 5(B)), meaning that there were weak (or lacking) interactions between the CNCs hydroxyl groups and the urethane groups. Thereby, the presence of UPy side-groups enabled a ne dispersion of the nanollers into hydrophobic PCL matrix as well as in chloroform, actually a very poor dispersant solvent for CNCs.
The microstructure of the PCL-UPy-CNCs nanocomposites and PU (1) was then observed by SEM. Before, the samples were immersed into liquid nitrogen and cut off vertically to the fracture surface. Fig. 6 shows cross-sectional SEM images of the neat PU (1) (Fig. 6(A)) and nanocomposite lms containing 2.5, 5, 10 and 15 wt% CNCs (Fig. 6(B)-(E)). As compared to the neat PU (1) lm, CNCs were clearly identied in the matrix as white dots and proved located in the perpendicular plane of the lm, as already reported in the literature. [51][52][53][54] As the CNCs content increased, numerous white dots at the surface extended as well. At low nanollers content, i.e. 2.5 and 5 wt%, a uniform distribution of the nanocrystals in the matrix with no large aggregates was observed, implying a good interaction between the CNCs and the UPy moieties. At 10 and 15 wt% of CNCs content, some voids appeared, suggesting CNCs aggregation. Nevertheless, together with the dispersion tests in chloroform, these images conrm the good dispersion ability of the CNCs into the PU (1) matrix.
Thermal, mechanical and SME investigations. The thermal properties of PCL-UPy-CNCs nanocomposites are listed in Table 2. Although T m insignicantly varied with composition (for neat PU (1) see Table 1), DH m increased with CNCs loading, and reached a maximum for PU (1) + 15 wt% CNCs suggesting a nucleation effect of well-dispersed CNC. However, these data are somehow deviating from the literature, where a maximum Paper in enthalpy is oen reported at 5 wt% nanoller loading due to the formation of a well-developed cellulosic network and hindering of the polymer crystallites growth. 52 One might suppose that CNC incorporation competes the UPy-UPy supramolecular network and allows UPy-CNC interactions, that preserve ne nanocrystals dispersion even at higher ller loadings of 15 wt% and allow their nucleation effect to be further expressed.
The results are somehow conrmed by the thermomechanical properties of the composites (Fig. 7). Indeed, T a (about À60 C) and T m (between 40 and 50 C) revealed in good agreement with DSC data. Interestingly, a second rubbery plateau occurred above T m at 70 C. This phenomenon was already reported for other PU-systems and ascribed to the formation of supramolecular structures by the aggregation of dimerized groups. 47 Only aer, complete owing of the system occurred and the temperature at which this last phenomenon occurs is called "owing temperature" (T f ). In the case of PU (1) + CNC nanocomposites, the T f (dened as the end of the second rubbery plateau) as recorded from the DMTA curves was situated at about 70 C, thus identifying it as an upper service temperature (Fig. 7). The value of the storage modulus at this point increased upon increasing the CNC loading and reached 1, 3, 5 and 10 MPa, for CNC content of 0, 5, 10 and 15 wt%, respectively, thus conrming that CNCs act as reinforcing agents in the supramolecular network of PCL-UPy polyurethane chains.
The rheological characterization of the nanocomposites (Fig. 8) shows their elastic modulus and the complex viscosity evolution in function of the frequency. As one can observe, samples with low CNCs content, i.e., 2.5 and 5 wt%, displayed a slightly reduced viscosity with respect to the neat PU (1), most probably due to the involvement of some UPy groups in hydrogen bonding with CNCs. However, composites containing 10 and 15 wt% CNC presented higher G 0 and viscosity in the low frequency range as expected from reinforcement. Interestingly, storage and loss modulus indicated a liquid-like behavior (G 00 > G 0 ) in the low frequency range (Fig. 8(B)-(E)), independently on CNC loading. A clearly marked cross-over of G 0 with G 00 appeared at 32 rad s À1 for the PU (1) + 2.5 wt% CNC which was twice higher the value recorded for the neat PU (1) (Fig. SI2 †). Thus, disrupted UPy-UPy interactions and formation of new UPy-CNC network are conrmed. It might be assumed, that the CNC loading is yet too low for sufficient network stabilization. Indeed, upon increasing the CNC content, this cross-over shifted to 19 rad s À1 (PU (1) + 5 wt% CNC) and reached 12.6 rad s À1 for PU (1) + 15 wt% CNC, conrming the stabilization of UPy-CNC network and xing the percolation at about 5 wt% nano-ller loading. As this behavior certainly originates from the different affinity between CNCs-CNCs, CNCs-UPy and UPy-UPy groups, it might be suggested that dimerization between UPy groups is enthalpically less favorable than the formation of clusters CNC-UPy or CNC-CNC in the supramolecular network.
Concerning the SME of the PU (1) + CNC nanocomposites (Table 2), a R f value of 100% and a R r value of 96% were obtained for 5 wt% CNCs sample, while both R f and R r values were close to 100% at 2.5 wt% CNCs content. This suggests that at low CNC loading (best illustrated with the case of PU (1) + 2.5 wt% CNC) some involvement of the UPy groups in hydrogen bonds with CNCs occurs, although their amount is yet not sufficient for a stable percolated network with restricted mobility to be formed. Instead, stabilization and higher mobility of the chains in the supramolecular network are ensured and best shapememory effect is observed. On the contrary, nanocomposites with higher CNCs contents (10 and 15 wt%) did not exhibit improved shape-memory features, keeping recovery behavior similar to the neat PU (1). For these samples, the percolation threshold between CNCs was quickly reached, thus modifying the SME properties of the materials. Accordingly, nanocomposites containing 2.5 and 5 wt% CNCs seemed to propose a good compromise in terms of shape-memory properties.

Conclusions
PCL-UPy linear polyurethanes with UPy content from 30 to 70 mol% were successfully obtained via chain-extension reaction with diisocyanates. For this purpose, the synthesis of UPydiol was rst developed. FTIR and 1 H NMR were used to conrm chemical structure and composition of all molecules, and SEC in chloroform attested the targeted increase in molar mass for the PUs. Thermal properties evaluation showed decreased melting enthalpy upon increasing UPy content and suggested that UPy dimerization forms a supramolecular network that might restricts the mobility of the PCL chains and thus reduce polyester crystallinity. The hypothesis was further conrmed by mechanical and rheology tests drawing PU (1) as most appropriate candidate for SMP.
The formation of a reversible supramolecular network based on hydrogen bonding was conrmed to be a good prerequisite for SMP recycling together with SME preservation.
Further improvement in PU (1) properties was achieved by nely dispersing CNCs as biobased nanollers able to form hydrogen bonds. The presence of interactions between UPy moieties and CNCs in the nanocomposites was demonstrated by dispersion tests and SEM. Evaluations of the inuence of CNCs loading by DSC, DMTA and rheology attested the presence of CNC-UPy interactions competing UPy-UPy dimerization; and tests on SME revealed improved R r values for PU (1) nanocomposites of low CNC loading (2.5 and 5 wt%).
The here obtained nanomaterials, combining PCL biocompatibility with CNCs bio-based origin and biocompatibility might nd possible applications in areas where both SMP and biocompatibility are needed for biomedical applications.

Conflicts of interest
There are no conicts to declare.