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Differing effects of azathioprine and cyclophosphamide on immune responses to flagellin in man.

Azathioprine and cyclophosphamide in doses of 3 mg/kg were assessed in humans with immunopathic diseases in respect to effects on humoral antibody production and counts of antigen-binding lymphocytes in blood, using flagellin as test antigen. The results for azathioprine-treated patients did not differ significantly from those for nontreated control patients, whereas for cyclophosphamide-treated patients there was significant suppression of humoral antibody to flagellin, especially IgG, and no increase in antigen-binding lymphocytes in blood after immunization. These and other observations, relating to inhibitory effects of azathioprine on T cells and antiproliferative effects of cyclophosphamide on B cells, could have implications for therapy of immunopathic diseases.