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The Mimic of Type II Aldolases Chemistry: Asymmetric Synthesis of β‐Hydroxy Ketones by Direct Aldol Reaction

An efficient direct aldol reaction has been developed for the synthesis of chiral β‐hydroxy ketone using a combination of C1‐symmetric chiral prolinamides based on o‐phenylenediamine and zinc triflate as catalyst. The reaction was convenient to carry out in aqueous media with up to 98% chemical yields and up to 94% ee values. The current strategy can be regarded as the analogue of aldolase type II, which suggests a new pathway for the designing of new organocatalysts.