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GENETIC DIVERSITY OF BALB/c, CBA, C57BL/6 INBRED MICE LINES USED IN MEDICAL AND BIOLOGICAL RESEARCH IN THE REPUBLIC OF BELARUS

Genetic polymorphism of the representatives of inbred BALB/c, C57BL/6, and CBA mice lines was studied using 10 STR markers. Among 30 individuals, 36 various alleles were identified. Using the algorithm of the Structure program, it was found that each line of mice is genetically differentiated from other lines and has its own allelic profile of microsatellite sequence loci. The study results may be used to monitor the purity of inbred mice lines in a number of generations.