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[Interactions between rheumatoid factors and antinuclear autoantibodies: their occurrence in a concealed state in rheumatoid disease (arthritis); effect of D-penicillamine].

In this paper it is demonstrated that IgM rheumatoid factor (RF) can inhibit the detection of antinuclear antibodies (ANA) by the classical rat liver cryostat section method. This "inhibition" of IgG-ANA by IgM-RF may be due to the formation of high molecular weight complexes. It would be the same in vivo. This masking effect can explain interesting similarities and dissimilarities observed in the clinico-immunological profiles of rheumatoid arthritis and systemic lupus erythematosus. D-Penicillamine can restore ANA activity by dissociating ANA-RF complexes. A new technique is described for the detection of these masked ANA.