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Changes in hypothalamic catecholamine neurotransmitters and pituitary gonadotropins in the immature female rat: relationships to the gonadostat theory of puberty onset.

The distribution of hypothalamic norepinephrine and dopamine tissue concentrations and the relative differences in norepinephrine turnover rate were studied in sexually maturing female rats. A modified radioenzymatic assay was used to measure norepinephrine and dopamine concentrations. Norepinephrine turnover was estimated by calculating the disappearance rate of intraventricularly injected [3H]norepinephrine over 24 h, with a correction for dilution of specific activity by endogenous norepinephrine tissue stores. Hypothalamic catecholamine content and norepinephrine turnover values were determined for the median eminence, anterior hypothalamus, and residual hypothalamus in 21-, 24-, 28-, and 31-day-old intact and 1-week postcastration animals. In addition, basal, postcastration, and post-LHRH serum LH and FSH levels were measured. In the intact rats, basal and post-LHRH LH and FSH levels did not change with age. Norepinephrine content in the anterior hypothalamus and residual hypothalamus of the intact r...