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The intention‐to‐treat principle in clinical trials and meta‐analyses of leukoreduced blood transfusions in surgical patients

BACKGROUND: The scientific method requires that only experiments actually and correctly performed be used to draw conclusions. The intention‐to‐treat principle requires that all patients, even those not or improperly treated, be included. In clinical trials and meta‐analyses investigating leukoreduced blood transfusions to reduce postoperative infections, the intention‐to‐treat principle and the scientific method have been variably applied.