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PSA and clinical problems relating to prostate cancer

The PSA is the most important tumoral marker for prostate cancer. Not all Authors agree that it plays an important role in screening and diagnosis, classification and prognosis; they agree, instead, about its monitoring the response to therapy. Two personal experiences are presented: in one the PSA values are compared with the prostatic biopsies in 100 patients with suspect rectal exploration; in the other the PSA value, taken at the moment of diagnosis, is compared with the result of the radionuclide bone scan in 43 patients with prostate cancer.