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Fat elimination in acute renal failure: long-chain vs medium-chain triglycerides.

This study compared the metabolism of intravenously infused fat in patients with acute renal failure (ARF) vs that in healthy control subjects, using either a long-chain triglycerides (LCT) emulsion or a 50:50 mixture of LCT and medium-chain triglycerides (MCT). The test subjects consisted of seven medical intensive care unit patients who had developed ARF due to various causes (sepsis in two; postoperative pancreatitis, vascular surgery, acute interstitial nephritis, poststreptococcal nephritis, and drugs in one each). These patients were considered otherwise clinically stable and were all close to ideal body weight (109 ± 3% ideal body weight). Prior to this study, the patients had been on parenteral nutrition, which provided 130% of resting energy expenditure and consisted of amino acids (15%), glucose (55%), and LCT lipids (30%). The control subjects were six healthy volunteers of somewhat younger age (32 ± 7 years vs 51.9 ± 4.4 years in the study group) and similar weight (103 ± 5% ideal body weight)...