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Comparison of Bungarus caeruleus venom with the venom from which a putative cholinergic ionophore marker was isolated.

Comparisons are described between Bungarus caeruleus venom and the actual venom from which a putative marker for the cholinergic ionophore, called ceruleotoxin, was isolated. The venoms are shown to be different by two procedures for ion exchange chromatography and by isoelectric focusing on polyacrylamide gel. The activities of the purified "ceruleotoxin" as an inhibitor of acetylcholine receptor-mediated ion flux and as a phospholipase have been reported (Bon & Changeux, 1977b). The results reported herein suggest that this toxin is from an unknown origin.