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ECMO and Sepsis. If Differences Could Be Due to Chance Alone, Are Trends Worth Discussing?

In Reply.—
 We agree with Dr Weiss that from a purely statistical standpoint, our retrospective data do not offer proof that ECMO is superior to conventional medical therapy in improving the survival of neonates with overwhelming group B streptococcal sepsis. If this study had more power (ie, more patients), a statistically significant difference may have been noted. Of course, with this particular study design, we had no control over sample size. It is up to the reader to decide if there is a clinically significant difference between the two therapeutic strategies.