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Isolation and Identification of C‐Mannosylated Hsc70 Conjugates in RAW 264.7 Macrophage‐Like Cells

Post‐translational addition of carbohydrate molecules is often necessary for proteins to be fully active. This process, known as glycosylation, usually involves a carbon‐nitrogen or carbon‐oxygen bond. There is, however, a form of glycosylation that involves formation of a carbon‐carbon bond. C‐linked glycosylation in higher organisms consists of the addition of α‐mannopyranoside from dolichyl‐phosphate mannose onto the C‐2 carbon of tryptophan's indole functional group, generating a residue known as C‐mannosyltryptophan. Though the function of this modification is not well characterized, the addition of α‐mannopyranoside to tryptophan residues is thought to play an important role in the innate immune response. (Muroi et al.; Hartmann and Hofsteenge; Hofsteenge et al.)