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Basal Ganglia and Prefrontal Regions Influence Postural Control and Cognitive Impairment in Parkinson's Disease

Postural instability is one of clinical manifestations caused by the deterioration of basal ganglia (BG) in Parkinson's disease (PD). It has frequently been found in moderate and advanced stages of the disease, simultaneously, impairments of cognition and executive function are also commonly present. Several studies reported interferences between postural control and cognitive tasks passing the prefrontal regions. We aimed to reveal the roles of BG and prefrontal regions in postural control and cognitive impairment in PD patients who exhibit freezing of gait (FOG).