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Effect of Bisdiamine Given to Pregnant Rats on Hemodynamics of Their Embryos

Developmental abnormalities of neural crest cells (NCC) produce congenital heart defects as well as an abnormal autonomic nervous system in chick embryos.',' Ablation or excision of NCC in the chick embryo is also associated with hemodynamic changes3 or altered response to cholinergic stimulation." Bisdiamine may affect the NCC system in the rat, producing conotruncal anomalies. Thus, we hypothesized that hemodynamic alteration may be produced in embryos of bisdiamine-treated mother rats. The specific aim of the present study was to clarify the effect of bisdiamine given to mother rats on baseline hemodynamics in their embryos and on hemodynamic responses to acetylcholine.