{'fraction_non_alphanumeric': 0.03002309468822171, 'fraction_numerical': 0.006158583525789068, 'mean_word_length': 4.990783410138249, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
A case of severe type of cerebro-costo-mandibular syndrome.

Introduction
Cerebro-costo-mandibular syndrome (CCMS) is a rare disorder, with only 75 cases described
in the literature to date. CCMS is characterized by association of micrognathia and specific multiple rib
defects. It is accompanied by mental deficiency in considerable number of cases. Sometimes, there are
associated anomalies and problems, such as spine deformities, brain, heart, kidney or ear anomalies,
feeding difficulties, delayed psychomotor development, and growth impairment. Depending on severity
of deformities and consecutive respiratory insufficiency, in about 35–50% of CCMS cases, death occurs
during the first year of life. These cases are referred to as severe types of CCMS.


Case Outline
In this paper we present a female infant with severe type of CCMS. Diagnosis was established
in the first day of life, based on micrognathia and findings of posterior rib-gap defects on the
chest X-ray, accompanied by dyspnea. Progressive severe respiratory insufficiency caused by chest and
air-way deformities and exacerbated by episodes of pneumonia, led to respiratory failure and death at
the age of 7.5 months.


Conclusion
CCMS should be considered in every infant with micrognathia and rib-gap defects on chest X-ray.