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A human CD4+ T‐cell line expresses functional CD64 (FcγRI), CD32 (FcγRII), and CD16 (FcγRIII) receptors but these do not enhance the infectivity of HIV‐1‐IgG complexes

T cells do not generally express Fc receptors (FcRs). However, we report here that C8166 cells, a human CD4+ T lymphoblastoid cell line, widely used in research into the human immunodeficiency virus type 1 (HIV‐1), expressed CD64 (FcγRI), CD32 (FcγRII), and CD16 (FcγRIII) on the plasma membrane as shown by immunostaining with specific monoclonal antibody fragments. Another human CD4+ T lymphoblastoid cell line, H9, expressed none of these FcRs. C8166 cells bound monomeric normal rat serum IgG in a dose‐dependent manner, and when saturated bound heat‐complexed immunoglobulin G (IgG) also dose dependently. These observations are consistent with the presence on the C8166 T‐cell line of both high‐ and low‐affinity FcγRs. FcγRs are putative receptors for virus–IgG complexes, but in this study did not enhance infectivity of HIV‐1 complexed with a human neutralizing mAb or three rat neutralizing mAbs. Virus complexed with a non‐neutralizing mouse mAb was unable to infect cells using FcγRs as receptors after CD4 was blocked with a specific anti‐CD4 mAb.