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Hesperidin‐mediated expression of Nrf2 and upregulation of antioxidant status in senescent rat heart

Objectives  Oxidative stress is recognized as a key element responsible for the development of age‐related pathologies. A declining endogenous defence system during senescence dictates the need for supplementation with exogenous antioxidants through diet. Hesperidin is a naturally occurring flavonone present in citrus fruits and has been shown to have many biological properties, including antioxidant activity. We investigated whether hesperidin supplementation could be valuable in protecting cardiac tissue of aged rats against age‐related increase in oxidative stress, as well as the mechanism by which it can boost the antioxidant status of the cell.