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[Detection and analysis of serum IL-10 and TGF-β1 in the SLE patients with osteoporosis or osteonecrosis].

Objective To detect serum levels of interleukin-10 (IL-10) and transforming growth factor-β1 (TGF-β1) in patients with systemic lupus erythematosus (SLE) with bone damage, and analyze their clinical significance. Methods The study included 56 patients with SLE. Serum IL-10 and TGF-β1 levels were detected by ELISA. The clinical data of 56 patients were retrospectively analyzed, mainly recording the cases of osteoporosis and osteonecrosis. According to different bone mass, they were divided into normal bone mass group (14 cases), reduced bone mass group (26 cases) and osteoporosis group (16 cases). According to whether or not there was osteonecrosis, the patients were divided into: no osteonecrosis group (49 cases) and osteonecrosis group (7 cases). SPSS18.0 software was used for statistical analysis. Kolmogorov-smirnov t test whether the data is normally distributed. The measurement data of normal distribution are analyzed by the two-tailed t test. For the measurement data of non-normal distribution, mann-whitney U test was used to analyze. Results Compared to the SLE patients with normal bone mass, SLE patients complicated with osteoporosis lowly expressed TGF-β1 and highly expressed IL-10. The serum level of IL-10 was higher in SLE patients with osteonecrosis than that in SLE patients without osteonecrosis. No difference was found in the TGF-β1 between two groups. Conclusion TGF-β1 level is reduced but IL-10 level is elevated in SLE patients with osteoporosis. Serum IL-10 levels in SLE patients with osteonecrosis are higher than that in those without osteonecrosis.