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Age-associated inclusions in normal and transgenic mouse brain.

Fig. 4. Age-related increase in number of inclusions in brains of male C57BL/6 mice. LBP-like immunoreactive clusters were quantified in 25-pim coronal sections through the dorsal hippocampus. For each animal, the number of clusters per unilateral hippocampus was determined in several sections and subsequently averaged. Numbers of mice were 6, 5, 4, 9, 9, and 17 at ages 0 to 2, 6, 9 to 10, 12 to 13, 18, and 24 to 31 months, respectively. Error bars represent SEM; ANOVA for age effect, F(5,44) = 5.26, P <0.001.