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Lipogranulomas in human liver biopsies with fatty change. A morphological, biochemical and clinical investigation.

The material comprises 67 percutaneous liver biopsies all with fatty change as the chief morphological diagnosis. Among others biopsies with cirrhosis and Mallory bodies have been excluded. Lipogranulomas have been found in 43 out of 67 biopsies. A description of lipogranulomas is given, and three types are described according to size and age. Steatosis is a conditio sine qua non for the development of lipogranulomas. Biopsies with lipogranulomas show higher histologic activity (lytic liver cell necrosis, acidophilic bodies and rnesenchymal reaction) and more parenchymal fibrosis than biopsies without. The patients with lipogranulomas have higher S. G. O. T. values. Whereas lipogranulomas type 1 and 2 can disappear without sequelae there is good reason to believe that lipogranulomas type 3 may give rise to development of connective tissue in the parenchyma.