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Effect of acute saline infusion on the cardiovascular deconditioning after 20-days head-down tilt bedrest.

Recent study showed that dehydration induced by prolonged exercise significantly impaired orthostatic tolerance with tachycardia and hypotension, and subsequent rehydration restored it. As physiological changes during exposure to actual or simulated microgravity can be viewed as dehydration process, we hypothesized that rehydration after prolonged bedrest may be a promising candidate to countermeasure not only fluid volume loss but also autonomic nervous deconditioning. Therefore, the purpose of present study was to determine the effect of acute rehydration by saline infusion on orthostatic cardiovascular deconditioning after bedrest.