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Endogenous corticosteroid biosynthesis in subjects after bilateral adrenalectomy

Objective  Corticosteroids can be synthesized in extra‐adrenal tissues but the contribution of this to circulating levels in humans is not known. Previous in vitro studies suggest that the ‘hybrid’ corticosteroid 18‐oxocortisol (18‐oxoF) is produced from cortisol by aldosterone synthase. We looked for evidence of extra‐adrenal production of this and other corticosteroids in 10 subjects stable on long‐term glucocorticoid replacement following bilateral adrenalectomy.