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Are the mRNA vaccines inducing the Sanarelli-Shwartzman phenomenon?

Adverse events of myocarditis, pericarditis, and thrombosis, temporally associated with mRNA vaccination(s) and/or mRNA vaccine boosters, have been reported during post-marketing safety surveillance in the U.S. CDC VAERS database and 2021 CDC guidance to physicians. An interim report unexpectedly revealed inflammatory biomarker elevations in vaccine recipients. During review of considerable published research on the Sanarelli-Shwartzman phenomenon (SSP) and the use of nucleic acids as vaccine adjuvants, a novel, hypothesis is proposed. Even today, after being studied for over a century, the pathophysiology of the SSP is not fully understood. Motivated by a paper from 1950, titled “General Adaptation Syndrome” by Hans Selye, and recent published research by Korean investigators, a novel, non-conventional hypothesis was generated. Gluten and lectin sensitivity are cited as examples of sensitizing events of the SSP, for which we propose ensemble hydrophobic chiroptical catalysis may have therapeutic benefit. Under the ensemble HCC hypothesis, we propose that inflammatory stress and scurvy promote loss of chirality control, anomeric fidelity, phenotypic stability, and immune function, both humoral and cell-mediated, with the dialyzable transfer factor, L-ascorbic acid, and spin water playing central roles. It is proposed that therapeutic synergy of L-ascorbic acid, bioflavonoids, and corticosteroids in countering the SARS-CoV-2 pathogen arises from memory of chirality which originated during their biosynthesis. It is proposed that ensemble HCC is powered by radiant and or zero-point energy (quantum vacuum fluctuations) which may support a paradigm shift to supramolecular biology. The distinction between supramolecular biology and supramolecular xenobiology is highlighted.