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The Angelman syndrome in two brothers.

We report two brothers with the Angelman syndrome. With the exception of the reports by Kuroki et al, all previously reported cases were sporadic. Overall sex ratio is M1:F1. Genetic heterogeneity may be present. Further data are required to determine emperic recurrence risks after a first occurrence in a family. A few cases may be due to autosomal or X-linked recessive inheritance. No chromosome abnormality has been found to date.