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Race is not prognostic in unfavorable prostate cancer: an NCDB analysis

Supplemental Digital Content is available in the text. Introduction: It is commonly held that race serves as a significant prognosticator in prostate cancer. We sought to analyze whether race impacted overall survival (OS) of men receiving standard of care treatment. Materials and Methods: All data was obtained from the NCDB (National Cancer Database) and initially contained 1,294,126 cases of prostate cancer diagnosed between 2004 and 2013. Patients were excluded if they had metastatic or nodal disease, received chemotherapy, or had noninvasive disease. Patients were grouped into 2 cohorts as per NCCN (National Comprehensive Cancer Network) criteria: favorable risk and unfavorable risk. All patients received risk-appropriate radiation therapy or surgery, and were subsequently analyzed. Black and white men were also matched 1:1 within each risk cohort using propensity scores, and multivariate analysis was conducted on these matched cohorts. Results: The final cohort 77,448 patients. Median follow-up 58.7 months (range, 48–143.5). In the favorable risk cohort, white men had superior OS compared with black men, 77.63% versus 80.57% at 10 years (hazard ratio, 0.644; 95% confidence interval, 0.536–0.773; P<0.001). In the unfavorable cohort, race was not a significant prognostic factor for OS on unmatched analysis; 10-year survival 73.6% and 71.3% (hazard ratio, 0.941; 95% confidence interval, 0.848–1.044; P=0.249), and significant interaction existed with age. Results were unchanged in propensity score matched cohorts. Conclusion: The prognostic value of race-related biological differences of prostate cancer may hold less value in higher risk disease than is commonly believed.

It is commonly held that race serves as a significant prognosticator in prostate cancer. Several retrospective series have demonstrated that black men with low risk (LR) prostate adenocarcinoma experience more rapid disease progression when placed on active surveillance (AS) and require subsequent definitive therapy in comparison to white men [1][2][3] . These differences have previously been theorized to be due to differences in tumor biology, such as tumor volume/prostate-specific antigen (PSA) ratio, Gleason score (GS) ≤ 6 and expression of several biomarkers [2,3] . Several studies have demonstrated that black men have more aggressive prostate cancer that transforms earlier and presents at a younger age compared with white men [4,5] , and are more often to have adverse features seen on pathology after radical prostatectomy (RP) [6] . Black men are also more likely to present with higher PSA and greater tumor burden than white men, which has been observed in a population of patients with equal access to care and screening [7] . In a matched analysis of a small cohort of T1c patients, black patients demonstrated significantly greater pathologic GS upstaging and tumor volume/ PSA ratio than their white counterparts [8] .
Socioeconomic factors and lack of access may be underlying these perceived differences between races [7,9] . An NCDB (National Cancer Database) analysis demonstrated that white men were more likely to receive definitive therapy for their prostate cancer compared with black men, which remained significant in subgroup analysis based on geographical region and facility type [9] .
Given the increasing evidence of significant differences in the biology and genetics of prostate cancer between black and white men, we sought to analyze whether race impacted survival of patients receiving appropriate standard of care treatment regimens using a large national database. database contains > 70% of new cancer diagnoses made in the United States.
The database initially contains 1,294,126 cases of prostate cancer cases diagnosed between 2004 and 2013. Only black and white men were analyzed in this study. All analyzed patients had a minimum follow-up of 48 months with documented follow up time. Patients were eliminated from the study if they had metastatic or nodal disease, received chemotherapy, or had noninvasive disease (Fig. 1). Patients receiving external beam radiotherapy (EBRT) must have received at least 7560 cGy. Patients were included only if they received risk-appropriate definitive therapy as described below. Those receiving surgery were allowed to receive adjuvant androgen deprivation therapy (ADT) or adjuvant EBRT.
Patients were first risk-stratified according to NCCN (National Comprehensive Cancer Network) criteria using clinical GS, PSA, and clinical T-stage. Patients were subsequently grouped into 2 broad cohorts: favorable and unfavorable risk. The favorable risk cohort included LR and favorable intermediate risk. Treatment modalities included RP with or without pelvic lymph node dissection (PLND), EBRT, or brachytherapy alone (BT).
For the unfavorable risk cohort, which consisted of unfavorable intermediate risk, high risk, and very high risk, treatment modalities included RP with PLND, EBRT + ADT, or EBRT + BT + ADT. Patients receiving surgery (RP alone or RP with PLND) were further classified into those receiving RT, ADT, or both RT and ADT as well.
The endpoint of interest was overall survival (OS) which was measured from the date of diagnosis to date of death; observations that were alive at time of last follow-up were censored. Black and white men were matched 1:1 within each risk category using calculated propensity scores.
Propensity score calculations utilized the following covariates: treatment received, facility type, facility location, time from diagnosis to initiation of treatment, insurance status, income level, comorbidity status based on the Charleson-Deyo score, NCCN risk group, GS, PSA, clinical T-stage, and age. Descriptive statistics were calculated using χ 2 analysis for each race in each risk cohort. Balance of cohorts was assessed using standardized mean differences of each covariate, with values <10% indicating a sufficiently matched cohort [10] . Kaplan-Meier survival curves were constructed and analyzed using the log-rank test on matched cohorts. All Cox proportional hazards models were constructed using variables selected a priori on unmatched cohorts and propensity score-matched cohorts (PS-MVA). Interaction testing was done between covariates and race, and those covariates with significant interactions were subsequently analyzed in stratified multivariate analysis.
A sensitivity analysis was done for both favorable and unfavorable cohorts. The first was done by stratifying those receiving RP by whether the technique was robotic or not, controlling for surgical technique which may have significantly influenced outcomes [11] . A second sensitivity analysis was done in the unfavorable risk cohort stratifying patients that received RP by weather adjuvant ADT and/or RT was used. Treatment groups were as follows: EBRT + ADT, EBRT + BT + ADT, RP with PLND, RP with PLND + ADT, RP with PLND + RT, and RP with PLND + ADT + RT. All P-values were 2-sided using a significance level of 0.05. Statistical analysis was done using R version 3.5.1.

OS and effect of race
In the favorable cohort, white men had superior OS compared with black men, 77.63% (74.31-81.10) versus 80.57% [95% confidence interval (CI), 74.21-87.47] at 10 years [hazard ratio (HR), 0.644; 95% CI, 0.536-0.773; P < 0.001, Table 1], which was also observed on PS-MVA (HR, 0.665; 95% CI, 0.498-0.887; P < 0.006, Table 1). The other significant predictors for improved OS in the favorable cohort was being treated at an academic/research facility, Charleson-Deyo comorbidity score score of 0 compared with 1 or 2 + , or younger age (  Table 4). Similarly, when controlling for surgical approach, no significant difference was seen between black and white men (HR, 0.942; 95% CI, 0.849-1.040; P = 0.256, Table 5). Significant interaction was seen between age and race on survival, and stratified analysis demonstrated black race was a more negative prognosticator in age younger than 60 compared with age older than 60 (

Discussion
Despite the abundance of previous evidence suggesting black men have a more aggressive prostate cancer compared with white men, our data introduces significant areas of research still to be explored.
In our cohort, race was a significant variable among LR patients, with superior survival observed in white men. Notably, this cohort did not include patients that remained on AS for the entire duration of the study as all patients in this study received definitive therapy, and our PS-MVA controlled for whether patients received treatment within 90 days of diagnosis, so delay of treatment is unlikely to explain this difference in survival. In addition, our PS-MVA controlled for socioeconomic factors including income, geography, and treatment facility, thus we    posit that the observed survival difference may be attributed to differences in disease biology between white and black men. Our current risk stratification may be failing to appropriately stage early prostate cancer in black men who may not actually have favorable risk disease. Such a difference in biology is consistent with several retrospective analyses, demonstrating that black men are at increased risk of upstaging which reflects a more aggressive disease process. In the Johns Hopkins active surveillance registry, black men clinically categorized as very LR had an increased risk of upstaging after RP compared with other races [1] . The group also found black men were more likely to be upstaged in serial biopsy based on grade rather than volume of disease, suggesting the need for a different criteria for selecting appropriate black men for active surveillance [12] . Another series of 272 patients on active surveillance found black race to be a significant predictor for upstaging on active surveillance after a median follow-up time of 2.9 years with a mean of 2.3 surveillance biopsies [13] . Similarly, a series from the University of Miami found black race to be a significant predictor for upstaging risk on AS [13] , while a series from Duke showed that black race significantly predicted for discontinuation of AS, reflecting disease progression [14] .
Current guidelines recommend that very low risk, LR, and favorable intermediate risk prostate cancer patients be considered for AS consisting of PSA testing every 6 months, digital rectal exam and biopsy annually [15] . Although AS prevents overtreatment of patients at LR of disease progression, many of the studies establishing the basis of this treatment paradigm were based on prior studies that underrepresented minorities [16] , particularly black men who are known to have significantly lower prostate cancer-specific survival rates compared with all other races.
It is important to note however that our study found that income bracket was the only socioeconomic variable to significantly interact with race on survival in the favorable cohort, which was further confirmed in the subgroup analysis. The significant interaction suggests there may be underlying socioeconomic variables not adequately captured in the NCDB which may contribute to the survival difference noted, and an exclusively biological explanation for the noted differences may not be completely accurate either.
Given that we found significant interaction between age and race on survival in the unfavorable risk cohort, we conducted a subgroup analysis using the age cut off of 60 as used in prior studies [17,18] to distinguish between "young" and "old" patients, in order to investigate weather race influenced outcomes differently in younger versus older cohorts receiving risk-appropriate definitive surgical resection or radiation therapy. Our analysis showed that race had no significant prognostic role in unfavorable risk patients, regardless of age.
A recent pooled retrospective study compared prostate cancerspecific mortality (PCSM) in patients with nonmetastatic prostate adenocarcinoma (cT1-4N0-1M0) using cases from SEER, the Veterans Affairs health system and four randomized clinical trial cohorts. Similar to our findings, the study demonstrated a stepwise reduction in a survival difference between black and white men after controlling for age, stage and socioeconomic variables, and demonstrated a lack of survival difference between the 2 races among the high risk subgroup. Interestingly however, black men had improved PCSM compared with white men in the cohort originating from the 4 randomized trials among all patients and in the high risk subgroup [19] . While our study did not demonstrate a survival advantage in black men, a significant interaction was found with age and race in the unfavorable risk cohort, with an increase in the HR for white race (reference black race) from age younger than 60 (HR, 0.862) to age older than 60 (HR, 1.070), which suggests that young black men with prostate cancer may have a more aggressive prostate cancer that is biologically distinct entity from that of young white men.
Notably, our study only included patients who received NCCN recommended standard of care treatments and could be adequately risk stratified. In particular, patients receiving radiation must have received adequate radiation doses (at least 7560 cGy), and unfavorable risk patients receiving EBRT must have received ADT as well. In addition, unfavorable risk patients receiving RP must have received a PLND. Our models also controlled for the interval between diagnosis to treatment initiation, and propensity matching ensured well-balanced cohorts to eliminate any treatment-related or socioeconomic imbalances between black and white men. Finally, our study is the first to observe the role of race on survival in different risk cohorts using the NCDB.
Unfortunately, the NCDB only records OS and not PCSM or biochemical recurrence-free survival, which are more meaningful endpoints in prostate cancer research. In addition, because of the nature of retrospective studies, our analysis is limited by a lack of randomization which could account for both known and unknown confounders. By carrying out a propensity-matched analysis, we were able to mimic the randomization process as closely as possible, but our model remains limited to the known variables available in the database. Although we created homogenized cohorts for comparisons in all our models, we inevitably lost observations by doing so, which may inadvertently introduce a selection bias. Therefore, our conclusions are only meant to be hypothesis generating.

Conclusions
Black men, while shown to be a negative prognosticator in patients with favorable risk prostate cancer, did not predict for worse OS in unfavorable risk disease, an observation made independent of socioeconomic and demographic factors. This suggests that the biology of disease plays a significant role in favorable risk cohorts, but in those with more advanced higher risk disease, these race-related biological differences carry no significant influence.

Ethical approval
NewYork-Presbyterian Brooklyn Methodist Hospital IRB.