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Prospects for modifying the allergic response by fish oil diets

Introduction The mediators which are generated and released in allergic reactions following activation of mast cells, and other mediator-containing cells, by IgE dependent or independent mechanisms may lead to immediate and persistent inflammatory responses. Mediators of hypersensitivity are pre-fonned and granule-associated or newly synthesized from membrane phospholipids. Granule associated mediators include histamine, eosinophil and neutrophil chemotactic factors, proteases, glycosidases and heparin proteoglycan. The newly generated mediators include those derived from the oxidative metabolism of arachidonic acid, namely leukotrienes and prostaglandins.