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Childhood kidney disease is associated with increased risk of end-stage renal failure in adulthood

Setting: Israel.

Patients: 1.5 million young people (aged 16–25) examined prior to military service between 1967 and 1997.

Exposure: Any history of childhood kidney disease, including structural anomalies and pyelonephritis.

Outcomes: Development of end-stage renal failure in adulthood.

Patient follow-up: Inclusion on the Israeli end-stage renal failure disease registry.

The study results are summarised in table 1.

View this table:

Table 1 
Risks of adult end-stage renal disease based on history of childhood renal disease



A history of childhood renal disease, even if there is no evidence of renal impairment in adolescence, is associated with significantly increased risk of end-stage renal failure in adulthood.

Abstracted from: Calderon-Margalit R, …