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Cytotoxic T‐Lymphocytes How Do They Function?

The central theme of this work has been the roles of the CTL receptor and of MHC-proteins in CTL recognition and lysis. A major conclusion that may be deduced from the work presented here is that one CTL receptor is responsible for both target cell recognition and lysis. Although their function as recognitive structures is well established, involvement of MHC-proteins in the events that follow recognition has not been investigated in detail. We have proposed that MHC-proteins are molecular mediators whereby CTL receptors transmit signals ultimately leading to lysis of the target cell. I see future work on CTL-mediated lysis proceeding in the following directions: 1. Verification and analysis of the precise role of MHC proteins in CTL recognition and lysis by use of cell and vesicle systems of defined composition and structure. 2. Study of CTL-mediated 'lethal hit' in systems enabling analysis of early events (millisecond level) preceding lysis. 3. Grafting of CTL receptor(s) activity onto naive cells, using liposomes or other vehicles, and 4. Production of idiotypic reagents such as monoclonal antibodies specific for the combining site/effector mechanism of CTL.