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Non-Hodgkin's lymphoma of bone marrow--an unusual presentation.

A clinico-morphological study of twelve patients of non-Hodgkin's lymphomas, diagnosed on bone marrow biopsy, is presented. They manifested with pyrexia of uncertain origin and/or unexplainable anaemia. These patients did not show any superficial lymphadenopa-thy, mediastinal lymph node enlargement or a specific mass in the abdomen. Eleven patients showed enlargement of the liver, whereas, eleven manifested with splenomegaly. Bone marrow aspirate and trephine biopsy performed as an investigational procedure, lead to a diagnosis of non-Hodgkin's lymphoma. According to the classification by W.H.O. (I978), six of them showed diffuse lymphoblastic lymphosarcoma, whereas, in the remaining six patients, the histological type was diffuse lymphocytic lymphosarcoma (JPMA 32:230, 1982).