{'fraction_non_alphanumeric': 0.01932367149758454, 'fraction_numerical': 0.007905138339920948, 'mean_word_length': 5.508571428571429, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Postprandial lipemia in coronary artery disease: effects of acipimox

BackgroundTriglyceride-rich lipoproteins circulating in the postprandial state have been postulated to play a role in the development of coronary atherosclerosis. We studied lipoproteins in healthy subjects who received an oral fat load and in patients with coronary artery disease receiving a similar meal and assessed the effects of acipimox. MethodsNine healthy subjects were compared with 15 patients with severe coronary artery disease. Triglycerides and cholesterol were estimated enzymatically in serum and lipoproteins before and 6 hours after a dietary fat load containing 100 g of fat with or without phor acipimox treatment. Lipoprotein fractions chylomicrons, very low density lipoproteins (VLDL), low-density lipoproteins (LDL), lipoprotein (a), and high-density lipoproteins (HDL) were isolated using a tabletop ultracentrifuge. Acipimox was given for 1 week (250 mg twice daily), the last dose being administered 12 hours before the study ResultsWe observed a characteristic lipoprotein profile in serum of patients with coronary artery disease. The concentration of triglycerides in serum, VLDL, and HDL and that of cholesterol in VLDL was higher than in healthy subjects, but cholesterol in HDL was less. After ingestion of 100 g of fat, a hypertriglyceridemic response was observed in all subjects. Triglycerides in serum, in VLDL, and in HDL and cholesterol in VLDL were still increased in all patients with coronary artery disease at 6 hours, and cholesterol in HDL was reduced at 6 hours compared with controls or the patient's own initial values. Following treatment with the antilipolytic drug acipimox, postprandial changes in lipids and lipoproteins were attenuated in patients with coronary artery disease. The triglyceride response in the serum, VLDL, and HDL fractions was much less pronounced. The cholesterol in VLDL was less at 6 hours and the decrease in HDL cholesterol was no longer significant. ConclusionsThese results suggest that there is a disturbed metabolism of postprandial lipoprotein metabolism with a prolongation of the hypertriglyceridemic phase in patients with coronary artery disease. This disturbance is partially reversible during treatment with acipimox.