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Impact of Vitamin D Status and High‐dose Vitamin D3 Administration on the Plasma Metabolome in Critically Ill Adults

Vitamin D deficiency is common in critical illness but the metabolic effects of vitamin D deficiency or supplementation in critical illness are little understood. Our objective was to use high‐resolution metabolomics of plasma to explore the impact on metabolism of vitamin D status and after high‐dose vitamin D3 treatment in critically ill adults.