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Vasopressin in the Elimination of Intestinal Gas

Patients with intestinal paresis were treated with a pituitary lobe extract by SCHAFER & HERRING (1906). BELL (1909) reported 'excellent results' with the same drug under similar conditions. MELVILLE (1936) observed constriction of the small bowel and rapid propulsion of barium emulsion into the colon after the administration of pitressin. Vasopressin is one of the hormones secreted from the posterior lobe of the hypophysis. Apart from its antidiuretic effect, it causes smooth musculature to contract. Pitressin in doses of 5 to 20 units once to three times before abdominal roentgenologic examination was reported upon favourably by COLLINS & ROOT, JUTRAS & CANTERO and by SCHEIBEL at about this time. Several investigations have since been published in which vasopressin, more or less contaminated with oxytocin, has been used. As a synthetic vasopressin is now commercially available and as the criteria for the classifications of the results have not been performed in earlier reports the present work was undertaken.