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Xenon clearance in the diagnosis of arterial occlusive disease.

ARTERIOGRAPHY IS THE MOST RELIABLE METHOD currently available for the diagnosis of obliterative arterial disease of the lower extremity. Nevertheless, a number of significant problems and complications associated with this method make its routine use both impractical and potentially hazardous. Although plethysmographic flow measurement has been felt by some to be the best noninvasive method available for the diagnosis of arterial occlusive disease, it too has certain drawbacks. The procedure itself is rather cumbersome and requires calibration each time it is used. In addition, it is best suited for the measurement of resting blood flow which cannot always distinguish the normal from the ischemic limb. The measurement of reactive hyperemic blood flow after a period of exercise or ischemia is particularly difficult to accomplish with this method. Plethysmographic pressure measurements, while simple to perform, provide a minimal amount of information and are not very accurate. Thus, it is apparent that there is a need for a simple, noninrasive procedure to measure blood flow in the ischemic limb. In 1949, Kety [4] first demonstrated that the blood flow to a given tissue could be readily calculated by measuring the rate