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The effects of an oral contraceptive, ascorbic acid and iron on glucose and copper metabolism in the rat.


 The effects of norethynodrel-mestranol, administered alone or by gavage in a diet high in ascorbic acid and/or iron, on glucose and copper metabolism were studied in the rat. After oral administration of glucose, serum glucose levels were significantly lower in animals receiving the high ascorbic acid diet (p less than .05) and in rats receiving norethynodrel-mestranol (p less than .01) than in controls. None of the dietary regimens had any effect on pancreatic histology. Norethynodrel-mestranol significantly increased serum levels of copper (p less than .05) and ceruloplasmin (p less than .01), and significantly reduced liver copper storage (p less than .01). 250 mg/kg diet of iron significantly increased copper and ceruloplasmin levels over those induced by 25 mg/kg diet of iron (p less than .05). The combination of norethynodrel-mestranol with high dietary iron and ascorbic acid intake did not adversely affect glucose tolerance and pancreatic histology.
