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Marijuana receptor caught in the act

Marijuana has been used both recreationally and as a drug for centuries, has been banned in many countries for decades, and has recently been legalized in some U.S. states. But researchers haven’t been able to get a high-resolution look at the way its active component, Δ9-tetrahydrocannabinol (Δ9-THC), interacts with its principal protein receptor in the body, cannabinoid receptor 1 (CB1). CB1 is a G protein-coupled receptor found mostly in central nervous system cell membranes. Last year, two groups managed to capture structures of CB1 bound to inhibitors and in a “switched off” state. Activated receptors break down more easily when manipulated, so they are harder to crystallize and analyze structurally. Now, one of the same groups—including Zhi-Jie Liu and Suwen Zhao of ShanghaiTech University, Laura M. Bohn of Scripps Research Institute Florida, and Alexandros Makriyannis of Northeastern University—has obtained high-resolution X-ray crystal structures of the receptor bound to two hydrocannabinol