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Characteristic Cracking Pattern Generated on Tissue Slice as a Useful Index for Medical Diagnosis

Although biopsy is one of the most important methods for diagnosis in diseases, there exists undesired ambiguity judged through the information obtained from the visual inspection of tissue slices. Here, we report that, with a simple treatment by use of a urethane sheet, characteristic cracking pattern is generated for tissue slices depending on the difference of disease state. We used the tissue slices obtained from mouse liver with different stages of disease: Healthy normal state, Simple steatosis, Non-alcoholic steatohepatitis and Hepatocellular carcinoma. It is suggested that the cracking pattern of a tissue slice caused by absorbing provides useful information for distinguishing among the disease states.