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[Slow influenzal infection developing in the progeny of mice as a result of infection of the females during pregnancy].

Transplacental transmission of influenza virus from female mice infected during pregnancy may be detected as early as one day after virus inoculation, and the concentration of the infectious virus in fetal tissues is proportional to the infective dose. The intrauterine infection of fetuses leads to the development in a portion of progeny of slow influenza infection the frequency of which depends on the size of the dose used for inoculation of pregnant females. The slow influenza infection developed with similar effectiveness in the progeny of SHK colony mice and C57BL/6 line. As a result of influenza virus infection of pregnant C57BL/6 mice, there were specimens among their progeny devoid of body fur resembling the line of athymic nude mice. It is suggested that the birth of such nude mice is due to reversible changes in the thymus occurring under the influence of influenza virus.