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A1635 Relationship among adiponectin, insulin resistance and atherosclerosis in non-diabetic hypertensive patients and healthy adults

Objectives: Adiponectin, which is secreted specifically by adipose tissue, has been shown to have anti-atherogenic and anti-inflammatory effects and to improve insulin resistance (IR). The aim of this study was to determine the correlations among adiponectin, IR and atherosclerosis in non-diabetic hypertensive patients and healthy volunteers. Methods: In this case control study, we collected complete demographic data from and measured several laboratory parameters in all enrolled subjects. HOMA-IR was calculated as an insulin sensitivity index. AIP, which is calculated as log (TG/ HDL-C), was a significant predictor of atherosclerosis and was a better predictor of atherosclerosis than LDL-C. Plasma adiponectin, IL-6, MCP-1 and MMP-9 concentrations were determined using ELISA. Results: A total of 309 participants were enrolled in the study. Hypertensive patients with IR (n = 93) displayed significantly higher HOMA-IR values and AIPs and lower adiponectin levels than hypertensive patients without IR (n = 121) and healthy adults (n = 95) (P < 0.05). Furthermore, circulating IL-6, MCP-1 and MMP-9 concentrations differed significantly between hypertensive patients and healthy adults (P < 0.05). Additionally, adiponectin levels were found to be inversely correlated with IL-6, MCP-1, and MMP-9 levels; HOMA-IR values; and AIPs in the clinical study. HOMA-IR values and adiponectin and creatinine concentrations remained independently associated with AIPs in all participants after adjustment for confounders via multivariate linear regression. Conclusion: Low adiponectin levels are positively correlated with decreased insulin sensitivity, increased pro-inflammatory cytokine production and worsening atherosclerosis in hypertensive patients and healthy adults.