{'fraction_non_alphanumeric': 0.037552155771905425, 'fraction_numerical': 0.005563282336578581, 'mean_word_length': 5.728971962616822, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Substance P inhibits the M‐current in bullfrog sympathetic neurones

Substance P (SP, 2.5–10 μm) was applied by rapid bath perfusion to bullfrog lumbar sympathetic neurones in vitro, voltage‐clamped through a single micro‐electrode. In unclamped cells, SP produced a depolarization accompanied by an increase in apparent input resistance. Under voltage‐clamp a voltage‐dependent inward current was induced by SP, during which the time‐dependent relaxations induced by square voltage commands were inhibited. It is concluded that SP inhibits the M‐current (IM), a species of voltage‐dependent K+‐current, and that IM‐inhibition was the primary cause of the inward current and membrane depolarization in the cells tested.