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1411 Breast cancer immunopeptidomes contain numerous shared tumor antigens

Background Hormone-receptor-positive breast cancer (HR+) is an immunologically cold cancer that has not benefited from advances in immunotherapy. In contrast, triple-negative breast cancer (TNBC) displays high levels of leukocytic infiltration and responds to immune checkpoint inhibitors. CD8 T cells, the main effectors of anti-cancer responses, recognize MHC I-associated peptides (MAPs). Our work aimed to characterize the repertoire of MAPs presented by HR+ and TNBC tumors. were identified in both subtypes of breast cancer and represent attractive targets for cancer immunotherapy. The higher prevalence and immunogenicity of TSAs in TNBC tumors provide a molecular rationale for the responsiveness of TNBC to immune checkpoint inhibitors.