{'fraction_non_alphanumeric': 0.016101694915254237, 'fraction_numerical': 0.002542372881355932, 'mean_word_length': 5.748571428571428, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Stepwise evolution of molecular nanoaggregates inside the pores of a highly flexible metal-organic framework.

The crystalline sponge method (CSM) primary application has been the unambiguous structural determination via Single Crystal X-ray Diffraction (SCXRD) of a single analyte encapsulated inside a porous MOF. As the host-guest systems often show severe disorder, their reliable crystallographic determination is very demanding thus the dynamics of the guest entering and the formation of nanoconfined molecular aggregates has not been in the spotlight yet. We extended the concept of the CSM stepwisely monitoring the structural evolution of nanoconfined supramolecular aggregates of eugenol with the concomitant displacement of DMF inside the cavities of a novel flexible MOF, PUM168, which exhibited nets dislocations as a result of the guest exchange and organization. The accurate interpretation of the whole electron density provides a series of unique detailed snapshots depicting the supramolecular guest aggregation, thus elucidating the tight interplay between the host flexible skeleton and the molecular guests, through the whole DMF-to-eugenol exchange process.