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Transmission of HIV-2 in a west African family household.

HIV-2 has been isolated from AIDS patients in Guinea-Bissau and the Cape Verde Islands. It is closely related to the simian T-lymphotropic virus III and to the human T-lymphotropic virus IV. It is more distantly related to HIV-1 which causes AIDS. HIV-1 is spread by sexual intercourse blood and transplacentally. HIV-2 is presumably spread the same way. The matriarch of a family in Guinea-Bissau died of slim disease and was found to be seropositive for HIV-2. Her husband was also seropositive but her 7 children and 2 grandchildren were negative indicating that sexual intercourse but not other close family contact transmits HIV-2.