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Assessment of factors related to carbohydrate intolerance I: OGTT glucose AUC (LB299)

The OGTT is a gold standard in assessing carbohydrate intolerance (CI) and insulin resistance. However, the test is costly and time consuming. This study examined whether a CI survey could predict response to an OGTT. 108 women (31.6±13 yr, 34.7±7% body fat, 25.3±4 kg/m2) donated fasting blood samples, completed a CI inventory, had body composition and health measures determined, and underwent a 75 g OGTT in which glucose samples and perceptions of CI symptoms were obtained at 0, 30, 60, 90, and 120 minutes. Pearson product correlations were performed to determine which factors correlated with OGTT glucose AUC. Results revealed significant correlations (p<0.05) in GAUC (264±46 mg/hr/dL) to G120 AUC (r=0.43), glucose AUMC (r=0.97), Cmax (r=0.91), fasting insulin (r=0.26), HOMA (r=0.30), height (r=‐0.28), resting HR (r=0.19), BMC (r=‐0.36), BMD (r=‐0.32), FFM (r=‐0.28), being overweight since very young (r=0.27), and slowly gaining weight after age 30. These findings indicate that OGTT GAUC is positively correlated with G120, insulin, and HOMA. Further, shorter women who gained weight as they got older with a higher resting HR and lower FFM, BMC, and BMD were more related to GAUC during a OGTT.