{'fraction_non_alphanumeric': 0.03234802007808143, 'fraction_numerical': 0.014500836586726157, 'mean_word_length': 4.787096774193548, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Complete response to pixantrone as a salvage therapy in a relapsed/refractory diffuse large B-cell lymphoma

DOI: 10.24292/01.OR.220300620.5 Copyright © Medical Education. All rights reserved. ABSTRACT Diffuse large B-cell lymphoma (DlBCl) is an aggressive form of non-Hodgkin lymphoma (nHl). It is one of the most common form of the disease. A combination of chemotherapy with anthracycline and a monoclonal antibody targeting CD20 is used as a I line therapy. About two out of three people with DlBCl achieve and maintain complete remission after this treatment. In case of relapse or refractory disease a salvage high-dose chemotherapy followed by autologous stem cell transplantation (HD-ASCT) is the standard of care. Patientrs who relapse after HD-ASCT have a very poor prognosis. Pixantrone is a new anthracycline derivative registered to treat relapsed/refractory DlBCl in adult patients. It is a cytostatic agent with a reduced cardiotoxicity comparing to classic anthracyclines. Herein, we report two cases of relapsed/refractory DlBCl treated with pixantrone as a salvage therapy. The first case concernes a 58-year-old female patient with a diagnose of DlBCl, who relapsed after four prior lines of therapy (r-CHOP, ICE, HD-Mtx, CSn radiation) and achieved complete remission after pixantrone therapy, but died of acute myeloid leukemia 3 months after the end of treatment. Second case is a story of a 75-year-old female patient treated with two prior lines of treatment (r-CHOP, r-IvE), who achieved complete remission after a III line of therapy with pixantrone. Pixantrone monotherapy proves to be effective in relapsed/refractory DlBCl. This treatment is well tolerated in a group of elderly patients and can be also used in a group of patients with a limited cardiac function.