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In vitro diagnostic assays are effective during the acute phase of delayed‐type drug hypersensitivity reactions

Background  Previous reports have suggested that drug‐specific lymphocyte proliferation assays (LPA) can be used retrospectively to confirm the culprit drug following delayed‐type drug hypersensitivity reactions (DHR). However, only limited evidence supports their use in aiding acute clinical management. The aim of this study was to compare the LPA against combination cytokine assays for potential use in the acute setting.