{'fraction_non_alphanumeric': 0.025438100621820236, 'fraction_numerical': 0.01950254381006218, 'mean_word_length': 5.47483989021043, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Intensive care admission for Coronavirus OC43 respiratory tract infections.

Background Coronavirus OC43 infection causes severe pneumonia in patients presenting with comorbidities, but clinical signs alone do not allow for viral identification. Objectives To analyze acute manifestations of Coronavirus OC43 infections and outcomes of patients admitted to an intensive care unit (ICU). Patients and methods Retrospective and monocentric study performed during a Coronavirus OC43 outbreak. We used multiplex PCR to detect an OC43 outbreak in Reunion Island during the 2016 Southern Hemisphere's winter: seven admissions to the ICU. Results Mean age of patients was 71 [67;76] years, SAPS II was 42 [28;53], pneumonia severity index 159 [139;182] vs 73 [40.5;107] for patients in medical wards, and 43% required mechanical ventilation. Comorbidities were diabetes mellitus (87%), chronic respiratory failure (57%), and chronic renal failure (29%). One patient died from Haemophilus influenzae co-infection. Conclusion As for MERS Co-V infections, underlying comorbidities impacted the clinical outcomes of OC43 infections.


Background
Human Coronavirus infections, including Coronavirus OC43, usually result in upper respiratory tract infections such as common cold. However, these viruses are responsible for severe lower respiratory tract illness in patients presenting with comorbidities, and may be associated with the development of neurological diseases such as encephalitis [1]. Coronaviruses are enveloped viruses with a large positive-sense, single-stranded RNA genome and a helical nucleocapsid. The epidemiological surveillance of Coronavirus infections is facilitated by real-time polymerase chain reaction (RT-PCR) techniques used for routine diagnosis. In the Northern Hemisphere, Coronavirus infections have a seasonal distribution and seem to be uncommon outside the cold season running from December to May [2].
Reunion Island is a Southern Hemisphere French overseas territory with 843,529 inhabitants located in the Indian Ocean between Madagascar and Mauritius islands. The climate is tropical with moderate temperatures and the cold and dry season runs from May to November concomitantly with the influenza season [3]. In 2016, no Coronavirus OC43 strain was detected before June in the hospital. As of July, a Coronavirus OC43 strain was detected in 26 samples by Fast-Track Diagnostics ® respiratory pathogens assay: seven from the sentinel practitioner network and 19 from hospital settings. Seven of these hospital strains were detected in patients admitted to the intensive care unit (ICU). A flowchart describing admissions to the ICU during this period is presented in Fig. 1.

Patients and methods
We carried out a retrospective review of the medical records to describe the clinical features of seven patients presenting with Coronavirus infection and the impact on the ICU. We collected demographic data, reason for admission, concomitant medical conditions, history of illness, clinical characteristics, results of laboratory investigations, disease assessment score including Simplified Acute Physiology Score II (SAPS II) and pneumonia severity index (PSI) of FINE [4], management, and outcome. SAPS II score is used to assess disease severity and is calculated using the worst 12 physiological indicators during the first 24 hours in the ICU. Continuous variables are presented as median and interquartile range, and categorical variables are reported as number or frequency. As per French law (L.1121-1 paragraph 1 and R1121-2 Public Health Code), neither informed consent nor approval from an ethics committee were necessary for anonymous data extraction from an analysis of patients' medical charts.

Results
The study population characteristics are provided in Table 1. A comparison between our cohort of patients and patients hospitalized in the medical ward is shown in Table 2. All patients were residents of Reunion Island and none had traveled recently. All patients were admitted for respiratory failure caused by viral pneumonia, but three patients also presented with pulmonary edema and one with septic shock. The median age of patients was 71 [67;76] years. Infections occurred in elderly patients presenting with several comorbidities who were admitted for serious conditions as evidenced by a high SAPS II and PSI scores. Time between onset of clinical signs and ICU admission was short for two patients presenting with chronic disease failure. The other patients presented with influenza-like illness several days before hospitalization. Chest radiographic findings were abnormal for all patients. Biological results revealed that all patients had leukocytosis with lymphopenia. Three patients required mechanical ventilation for 4, 6, and 7 days. No patient needed a respiratory assistance with extracorporeal membrane oxygenation. All patients but one were treated with empirical antibacterial drugs: spiramycin and cefotaxime or piperacillin/tazobactam. One (14%) patient died: a 79-yearold woman presenting with type 2 diabetes, severe chronic obstructive pulmonary disease, and prior exposure to traditional firewood for cooking. She was admitted for acute exacerbation

Discussion
The small number of patients, not necessarily requiring mechanical ventilation, and the duration of stay seem to indicate a low epidemic impact. However, Coronavirus epidemics may be contemporaneous with an influenza outbreak.
Clinical aspects of Coronavirus infection cannot be recognized in the absence of laboratory investigations as coronaviruses are usually responsible for illness that cannot be distinguished from that caused by many other viruses. A cross reactivity between Coronavirus (in particular SARS-CoV and OC43) must be considered when interpreting serological tests for Coronavirus [5]. Since the emergence in the 1990s of nucleic acid amplification-based techniques, especially PCR, the diagnosis of several viral agents causing pulmonary infections has greatly improved. The use of a multiplex PCR test for respiratory tract infection allows for a high rate of detection of etiological agents, and enables the detection of Coronavirus outbreaks [6]. Antiviral drugs are yet to be developed in the treatment of Coronavirus infections, but characterization of such severe infections in patients presenting with comorbidities or in immunocompromised patients could enhance the medical research. These outbreaks mainly occur when the temperature is low. However, Coronavirus OC43 outbreaks have been reported in tropical climates: Malaysia [7] and Brazil [8] in 2012-2013. The 2016 Southern Hemisphere's winter in Reunion Island was among the coldest of the last decade [9]. This could have induced a small increase in ICU admissions of elderly and frail patients.

Conclusion
OC43 infection cannot be detected on the sole basis of clinical signs. The presence of underlying comorbidities impacted the clinical outcomes of OC43 infections, similar to what is observed in the ongoing MERS-CoV infection in the Middle East.