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The role of CaMK4 in immune responses

Abstract Calcium/calmodulin-dependent protein kinase IV (CaMK4) is a multifunctional serine/threonine kinase that regulates gene expression by activating transcription factors in a wide range of immune cells including T cells and antigen-presenting cells. The function of CaMK4 is suggested to be abnormal mainly in systemic lupus erythematosus (SLE), which is characterized by autoantibody production, immune complex formation, and immune dysregulation. Although accumulating evidence indicates that CaMK4 plays important roles in the immune responses, the precise molecular mechanisms underlying the development of autoimmune diseases and inflammatory disorders have not been established. In this review, we briefly summarize the role of CaMK4 in immune responses. We also discuss T-cell signaling pathways that control interleukin (IL)-17 production in patients with lupus nephritis and in glomerulonephritis in lupus-prone mice. A better understanding of the signaling and gene regulation of CaMK4 will lead to the identification of novel therapeutic targets in Th17 driven-autoimmune diseases.