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Effect of Malathion on Testicular Histology in Albino Mice and the Protective Effect of Vitamin E Melebary,

The present study shed the light on the possible preventive effect of Vitamin E against the toxicity of malathion (MP), an organophosphate pesticide, on body and testes weight, morphometry of the testes and epididymis as well as histological structure of testes in albino mice. Mice were divided into six groups: control (C), Vitamin E-treated group (VE), Low dose malathion-treated group (LD), High dose malathion-treated group (HD), Low dose malathion plus Vitamin E-treated group (LD+VE), and High dose malathion plus Vitamin E-treated group (HD+VE). The obtained results showed that the treatments with LD and HD have caused highly significant decreases in the average body weight and both right and left testes ratio weights. Furthermore, light microscopic examination disclose that a month of malathion exposure was linked with necrosis and edema in seminiferous tubules and interstitial tissues. Decaying changes in the seminiferous tubules were also noted in mice that were treated with malathion and vitamin E but histopathological alteration were clement in interstitial tissues. Based on the observation it seems that vitamins E enhance malathion testicular toxicity but still remains un-preventive to a degree. [Melebary, S.J.; Elnaggar, M.H.; Abu-Zinadah, O.A.; Kurdi, L.A. and Algamdi, M.S. Effect of Malathion on Testicular Histology in Albino Mice and the Protective Effect of Vitamin E. N Y Sci J 2017;10(5):97-105]. ISSN 1554-0200 (print); ISSN 2375-723X (online). http://www.sciencepub.net/newyork. 14. doi:10.7537/marsnys100517.14.