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Thrombocytes in fibrinogen-induced arthritis in rabbits.

A study has been made of the relationship between platelet counts and immunologically active arthritis. Arthritis was induced by infra-articular injections of human fibrinogen into rabbits that had previously been immunized. Transient thrombocytosis was noted in some animals after the first intra-articular injection. A second injection gave rise to a persisting elevation of the platelet levels. The local synovial process seems to represent an Arthus type of reaction. In all probability, thrombocytosis is a compensatory phenomenon secondary to the initial consumption of platelets in the damaged tissues. The resemblance between rheumatoid arthritis in man, and that noted in this experimental model, is discussed.