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Disposition of Polaprezinc (Zinc l‐Carnosine Complex) in Rat Gastrointestinal Tract and Effect of Cimetidine on its Adhesion to Gastric Tissues

The disposition of polaprezinc in the rat gastrointestinal tract was studied by a double tracer method using [14C]‐ and [65Zn]polaprezinc. At 0·5 h after oral administration of [14C]‐, [65Zn]polaprezinc to rats, the 14C‐radioactivity in the gastric contents was comparable with the 65Zn‐radioactivity. However, a significant difference was observed in the time course of changes in gastric contents between 14C‐ and 65Zn‐radioactivity over 1 h after administration, indicating that polaprezinc existed in complex form at 0·5 h after administration and was dissociated to l‐carnosine and zinc in the gastrointestinal tract as a function of time.