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VASCULAR COMPONENT OF AIRWAY REMODELING IN ASTHMA IS REDUCED BY HIGH DOSE OF FLUTICASONE

Chetta A, Zanini A, Foresi A, et al. Am J Respir Crit Care Med . 2003;167:751–757 

To assess the effect of short-term treatment with high-dose (500 μg, twice daily) and low-dose (100 μg, twice daily) inhaled fluticasone propionate (FP) on the vascular component of airway remodeling among asthmatic patients.

Thirty nonsmoking patients with mild/moderate asthma and baseline forced expiratory volume in 1 second values of ≥70% of predicted values. All patients had experienced no asthma attacks in the previous 2 months and controlled their symptoms with inhaled salbutamol …