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Treatment choice for diabetic macular edema.

Macular edema is a common cause of vision loss in patients with diabetes. Chronic elevation of serum glucose levels leads to capillary damage that results in microaneurysm formation in the retina. Leakage from these microaneurysms leads to vision loss if the fluid involves the center of the fovea. The mainstay of therapy for more than 25 years was focal laser photocoagulation applied to or near the microaneurysms.1 However, results from clinical trials of drugs that block vascular endothelial growth factor (VEGF) for the treatment of diabetic macular edema have led to a dramatic shift away from laser therapy to primary . . .