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Quantitative bioluminescence tomography from single view measurement with decay correction strategy

This paper presents a quantitative reconstruction scheme for bioluminescence tomography from single view measurement. With a priori information of sources sparsity, sparse regularization method is employed to act as an algebraic stabilizer to tackle the highly ill-posedness of BLT inverse problem. In the reconstruction process, the decay of bioluminescence light is also taken into account, and an attenuation correction strategy combines with 11-norm minimization is used to recovery the source distribution from limited measurements. Phantom experiments demonstrate that the proposed scheme can accurately localize and quantify source distribution while maintaining solution stability.