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Interaction of the heme oxygenase system with the renin‐angiotensin system in DOCA‐salt hypertensive rats

Heme analogues are known to lower blood pressure in a variety of hypertensive models, including angiotensin‐II‐infused‐, phenylephrine‐induced‐ and deoxycorticosterone acetate (DOCA)‐salt‐induced hypertensive models. In DOCA‐salt rats, elevated activity of the renin‐angiotensin system (RAS) leads to oxidative stress, inflammation and hypertrophy. Whether the application of a heme oxygenase inducer like hemin will attenuate RAS activity and suppress kidney hypertrophy needs clarification. Moreover, the interaction of the heme oxygenase system with the RAS in DOCA rats is not fully understood.