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Hereditary angioedema with a mutation in the plasminogen gene

Hereditary angioedema (HAE) with normal C1‐INH (HAEnCI) may be linked to specific mutations in the coagulation factor 12 (FXII) gene (HAE‐FXII) or functional mutations in other genes that are still unknown. We sought to identify and characterize a hitherto unknown type of HAE with normal C1‐INH and without mutation in the F12 gene.