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Ex-Vivo Evaluation of Eflornithine Hydrochloride Loaded Solid Lipid Microparticles Based Cream

Hirsutism is an unpleasant condition that affects a large number of women. Hirsutism can make females feel exceedingly self-conscious, jeopardizing their sense of femininity as well as their self-esteem. They are employing established treatments without evaluating their negative consequences, necessitating the development of new procedures. EFH loaded solid lipid microparticles (EFH-SLM) were manufactured using the solvent evaporation technique using polymers. Hair regrowth investigations in healthy Swiss albino female mice were carried out ex-vivo. Animals treated with EFH-Cream and EFH-SLM-Cream had the fairest and least dense hair densities on day 21. In comparison to regular EFH-Cream, this revealed that cream loaded with EFH-SLM was more efficient. On day 21, hair weight per cm2 was weighed for all groups of animals, and it was discovered that there was a substantial difference between animals treated with EFH-cream and EFH-SLM-Cream, which could be related to EFH-increased SLM's permeability. In comparison to animals treated with EFH-Cream and marketed EFH cream, animals treated with EFH-SLM-cream had fewer or no skin rashes or inflammation.