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27 PLASMA MOTILIN (Mo), PANCREATIC POLYPEPTIDE (PP) AND SOMATOSTATIN (So) LEVELS VARIATIONS DURING INTESTINAL CYCLIC MOTOR ACTIVITY (ICMA) IN CHRONIC INTESTINAL PSEUDO-OBSTRUCTION SYNDROME (CIPS) IN CHILDREN

In healthy adults, plasma Mo and PP levels increase significantly during ICMA at the end of phase 2 (P2) and the onset of phase 3 (P3) as compared to phase 1 (P1).Our aim was to study the correlation between plasma Mo, PP and So levels variations and the ICMA 3 phases in children with CIPS (visceral neuropathies).6 children (4 boys, 2 girls; mean age : 22.6 months)were studied. Intestinal manometry was recorded in each child during 6 hours and blood samples were taken at P1, at the end or P2 and the onset of P3 for Mo, PP and So radio-immunoassay.In 5 children, ICMA P1, P2 and P3 appeared spontaneously and in one case a P3-like after trimebutine intravenous injection. Plasma levels (pg/ml) of Mo (274±137) and PP (45±17) at the end of P2 and at the onset of P3 : Mo (230±61) and PP (39±13) did not increase as compared to P1 values (Mo−: 321±188 and PP : 49±31). Moreover, plasma Mo P1 levels were statistically higher and PP levels lower as compared to healthy adults values (n = 12, Mo : 157±46; PP 132±45). Plasma So levels did not vary significantly during the ICMA phases.These results suggest that in CIPS, a dysregulation of hormonal control (Mo, PP) of ICMA exists. Plasma Mo and PP determination could be of interest for CIPS diagnosis.