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High Throughput Assay for Bacterial Biofilm Formation on Biomaterials

INTRODUCTION: There has been increasing use of various synthetic and biologically derived materials in surgery. Biomaterials are used in many plastic surgery procedures, from hernia repairs to breast reconstruction. In particular, accelular dermal matrix material has gained popularity in various applications. There is a paucity of data on how acellular dermal matrix compares to other biomaterials as substrate for bacterial biofilm formation. Bacterial biofilm have been implicated in prosthetic wound infections. We have designed a high-throughput assay to evaluate Staphylococcus aureus biofilm formation on various biomaterials.