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Articles of Significant Interest Selected from This Issue by the Editors

Once thought to have entered the human population, xenotropic murine leukemia virus (XMRV) is a retrovirus that was later found to be a laboratory artifact. XMRV was derived from a unique recombination event between two endogenous murine leukemia viruses (MLVs) that occurred during passaging of a human tumor in nude mice. Cingöz et al. (p. 328 –338) have mapped the genetic loci of these two ancestral MLVs in the mouse genome and analyzed their distribution in different mouse strains. The differences in strain distribution make an independent recombination event in the wild extremely unlikely, lending further support to the idea that XMRV could only have been created in the laboratory.