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Ebola Species and Strain Number of Known Human Infections Percentage of Deaths Among Cases Zaire Mayinga

Ebola virus is one of only two known members of a family of RNA viruses, the Filoviridae. (The other member is the Marburg virus.) The Filoviridae consists of enveloped viruses containing a non-segmented negative-stranded RNA genome. The Ebola genome shows a linear gene arrangement in the order 3' untranslated region -nucleoprotein (NP) -viral structural protein -(VP) 35 -VP40 -glycoprotein (GP) -VP30 -VP24 -polymerase (L) -5' untranslated region. Genes are flanked at their 3' and 5' ends by highly conserved transcriptional start and termination signal sequences, respectively, which all contain the pentamer 3'-UAAUU-5'. The genes show three overlaps that alternate with intergenetic sequences (Klenk et al, 2000).