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[Possible ways of modeling latent influenzae infection in mice].

A latent influenza infection was produced experimentally in three ways: after experiencing the disease, after immunization with a live virus, as a result of vertical transmission of the virus persisting in females. In the latent influenza infection forming after the disease the duration of virus persistence was 112 days postinfection. The persisting virus from the animals receiving a single immunization was isolated only up to 35 days postinoculation. Both after the disease and immunization with a live virus the persisting infectious virus was found in the lungs in low titres not exceeding 1 lg EID50/0.2 ml. In contrast, a latent influenza infection in mice born to mothers-virus carriers was characterized by virus persistence in the blood and viscera in titres of 10(1) to 10(2) EID50/0.1 ml. Features of influenza virus persistence and conditions of its formation in mammals by the three ways mentioned are discussed.