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Does pharmacotherapy reduce the rate of decline of lung function in COPD?

The first area is the effect size. There are four previous landmark studies on the effects of inhaled steroids on rate of lung function decline. None of these studies showed a statistically significant reduction in rate of decline. Admittedly, none of them was sufficiently powered. The number of patients involved ranged from 145 to 643 per group, which falls short by a factor of two at least. However, the effect size was considerably smaller than observed in the present analysis, ranging from -4 to 12 mL/year. Hence, it would be interesting if the authors would present their views on why in the current study the effect size seems disproportionately larger.