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Prevalence of ocular surface disorder and its effect on quality of life in patients with glaucoma using topical antiglaucoma medications

Purpose: The objective of this study was to check for the presence of dry eye syndrome in patients using either a single or a combination of antiglaucoma medications and to analyze the symptoms of such patients versus controls with the help of Glaucoma Symptom Scale (GSS) and Ocular Surface Disease Index (OSDI) questionnaire. Materials and Methods: A cross-sectional prospective nonrandomized study was undertaken in 132 eyes of 66 patients (38 patients [G1] using a single drug and 28 patients [G2] using a combination of drugs) and a control group of 64 eyes of 32 participants (G0). Both the cases and the control group participants were evaluated for the presence of dry eye symptoms by statistically comparing the values obtained from tear break-up test (TBUT) and Schirmer's test. All the participants had to complete the self-administered versions of GSS questionnaire and also had to answer the OSDI questions. Results: The mean values of TBUT measured in seconds and of Schirmer's test measured in millimeters were lower while the mean values obtained by OSDI were higher in patients with glaucoma on more than a single drug and in those on treatment for more than 1 year. Conclusion: The rate of dry eye was higher in patients with glaucoma than in controls. Clinical features were directly proportional to the duration of therapy and amount of drugs prescribed.