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The study of biogenic iron oxide nanoparticles effects on iron status in male rabbits infected with T. evansi

Article history: Received October 31, 2021 Accepted December 17, 2021 Available online December 11, 2021 The present study aimed to evaluate the effects of propolis-iron oxide nanoparticles in eliminating the T. evansi parasite and rehome stasis of deleterious iron status in experimentally infected rabbits. Twenty male rabbits were divided into equal four groups (n=5). the 1 group as Control negative, 2 control positive, 3 trypanosomiasis and treated with propolis iron oxide nanoparticles, and 4 trypanosomiasis and treated with diminazene,2 ,3, and 4 groups were inoculated with T. evansi, and were checked for the onset of parasitemia. After 15 of the onset of parasitemia 3 group was treated with propolisiron-oxide nanoparticles 30 mg iron /kg BW, and 4 group was treated with diminazene drug with a single dose 3.5 mg/kg BW. The result showed that experimentally infection with T. evansi caused a significant decrease of serum iron and ferritin and a significant increase in total iron-binding capacity and unsaturation iron-binding capacity, as well erythrocytes fragility, bilirubin totally and partially. Treatment with propolis-iron oxide nanoparticles improved iron status parameters to semi-normal values much better than diminazene drug, in addition, reduced the total bilirubin concentration and osmotic fragility of erythrocytes toward a normal state. It can be concluded that the propolis-iron oxide nanoparticles proved successfully rebalancing iron status and eliminating the parasite and making iron available.