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"Activated Protein C (APC) Promotes A Healing Phenotype in Cultured Murine Tenocytes Via Protease- Activated Receptor (PAR)-2, but not PAR-1"

Xue. Activated Protein C (APC) Promotes A Healing Phenotype in Cultured Murine Tenocytes Via Protease-Ac-tivated Receptor (PAR)-2, but not PAR-1. Tendinopathy is a tendon pathology often resulting from a failed healing response to tendon injury. Activated protein C (APC) is a natural anti-coagulant with anti-inflammatory and wound healing promoting functions, which are mainly mediated by its receptors, endothelial protein C receptor (EPCR) and protease activated receptors (PARs). This study aimed to determine whether APC stimulates tenocyte healing and if so, to assess the involvement of the receptors. Methods: Mouse-tail tenocytes were isolated from 3-week-old wild type (WT), PAR1 knockout (KO) and PAR-2 KO mice. The expression of EPCR, PAR-1 -2 the of APC on tenocytes tendon healing underlying were by Reverse transcription real time PCR, western blot, 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, zymography, and scratch wound healing/ migration assay.