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Tracking inner retinal changes associated with glaucoma progression with AO-OCT

Glaucoma causes progressive loss and degeneration of retinal ganglion cell (RGC) axons and their somas. Until recently, cellular-level RGC imaging in live human subjects was not possible. Our initial cross-sectional study revealed differences in morphological parameters in ganglion cell layer (GCL) soma with glaucoma. The manner in which cellular-level morphology is altered during glaucoma progression has yet to be discovered. In this study, we used AO-OCT to track RGC morphology in one glaucoma patient with a hemifield defect. We found dynamic tissue remodeling in the GCL, resulting in a decrease in soma density and an increase in soma size.