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[Molecular biology and serology in the ABO system].

Using high-affinity monoclonal anti-A und anti-B antibodies the B(A) and A1(B) phenomena were detected. This is due to the high similarity of the final transferases adding the A- and B-specific sugars. In the meantime these proteins have been cloned and the biochemistry explains the serological findings. In addition, also for the AB0 subgroups transferases of different activities have been found and cloned, giving also here the answer to the differences between A1 and A2.