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Lighting up endosomes

Cell Biology
Endosomes are small, dynamic vesicles that sort and deliver signaling molecules to the correct location in the cell. Gupta et al. describe a new probe comprising a lipid-like small molecule that localizes to late endosomes, which they conjugated to a dye suitable for super-resolution imaging. These high-density, environmentally sensitive probes allowed them to visualize endolysosomes in primary cells for more than 7 minutes without affecting their structure or function. They were able to detect transient interactions between endosomes and identify endosome motility defects related to mutations associated with Niemann-Pick disease, a neurodegenerative endolysosomal storage disorder. These tools could be used to screen for small molecules that alter endosome dynamics.

Nat. Chem. Biol. 16 , 408 (2020).