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The pH‐dependence of chloroquine uptake by phosphatidylcholine vesicles

The pH‐dependence of chloroquine uptake by phosphatidylcholine bilayered vesicles was investigated to examine the relative affinity of ionized and un‐ionized chloroquine species to membrane bilayers. The results suggest that the neutral species and monocation are taken up by the bilayers but only the un‐ionized species interacts significantly with the hydrocarbon interior.