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Premenstrual Pregnancy Loss

Early pregnancy wastage refers to the loss of a pregnancy at any stage between implantation and the end of the first trimester. Naturally the causes of pregnancy loss occurring over such a relatively wide interval are numerous and will differ with the length of gestation. Furthermore a substantial amount of early pregnancy loss can only be detected by the finding of elevated human chorionic gonadotrophin (hCG) concentrations in maternal plasma or urine. These suspected pregnancies have been termed biochemicald because frequently no alternative confirmation of pregnancy (e.g., fetal heart on ultrasound) is available before the patient experiences vaginal bleeding and occult abortion.’ Following in vitro fertilization and embryo transfer (IVF and ET), many centers have recognized a higher than normal incidence of early pregnancy wastage and in