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New insights into germ cell tumor genomics

Testicular germ cell tumors (GCTs) represent the most common malignancy in young men. While GCTs represent a model for curable solid tumors due to exquisite chemosensitivity, mortality for patients with GCT comprises the most life years lost for non‐pediatric malignancies. Given limited options for patients with platinum‐resistant disease, improved insight into GCT biology could identify novel therapeutic options for patients with platinum‐resistant disease. Recent studies into molecular characteristics of both early stage and advanced germ cell tumors suggest a role for rationally targeted agents and potentially immunotherapy.