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Cohort study of relation between donating blood and risk of myocardial infarction in 2682 men in eastern finland

Mild iron deficiency has been hypothesised to reduce risk of heart disease risk,1 while a high concentration of body iron has been suggested as a risk factor for myocardial infarction.1 2 Menstruation in women and voluntary blood donations are the most important causes of blood loss and thus modulators of stores of body iron. We prospectively investigated the association of donating blood with the risk of acute myocardial infarction in a random population sample of middle aged men.

We investigated the incidence of acute myocardial infarctions in participants in the Kuopio ischaemic heart disease risk factor study.3 During 1984-9 we carried out baseline examinations of 2682 (83%) of the 3235 men aged 42, 48, 54, or 60 whom …