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High Fat Diet Blunts the Activation of Canonical Wnt Signaling Pathway Induced by Radiation Therapy in Mouse Colon Epithelia

Radiation stimulates multiple metabolic pathways in colon epithelial cells in mice, including the Wnt signaling pathway. Activation of Wnt/β‐catenin pathway was indicated to increase resistance to radiation therapy. On the other hand, we have shown that long‐term consumption of high fat diet inhibits Wnt signaling through the down‐regulation of β‐catenin expression in colon.