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Some endocrinological and anti-fertility properties of an androstane cyanohydrin derivative in the rat.

Bioassays were conducted to determine the effect of 17ocyanoA'�androsten�3a,17a.diol diacetate (A#{176}-diacetate) on pregnancy in the rat and to offer some explanation of its mode of action as an anti-fertility agent in that species. The compound possessed little or no estrogenic potency, was a weak gonadotropin inhibitor, had neither progestational nor anti-progestational activity, was only slightly androgenic and did not reduce levels of circulating progesterone. It interrupted pregnancy in intact rats but had no abortifacient activity if they were ovariectomized and pregnancy was maintained with ovarian steroids. 17n-cyanoestradiol diacetate, the simple ester of a possible aromatic conversion product of A'-diacetate, was found to be a potent uterotropic agent and, presumably, estrogenic. It was concluded that 17o-cyano-A5-androsten-3�3,17j3-diol diacetate is probably converted by the ovary of the intact pregnant rat to estrogen(s) and it is the latter compound or compounds which may be responsible for terminating pregnancy.