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Effect of some drugs on clinical laboratory values as determined by the Technicon SMA 12-60.

We examined the quantitative in vitro effects of 45 drugs on 12 automated biochemical laboratory tests done on the Technicon SMA 12/60. Of these, 25 drugs in 1 mmol/liter concentration interfered in one or more of the assays. However, only eight drugs (N-acetyl- p -aminophenol, p -aminosalicylate, isoniazid, L-dopa, α-methyldopa, 6-mercaptopurine, sulfathiazole, and ascorbic acid) reacted positively with the test reagents at concentrations likely to occur in plasma after administration of maximum single therapeutic doses. A slight false elevation of plasma uric acid and a major false increase in urine values occurred in patients after ingestion of N-acetyl- p -aminophenol and phenacetin, corresponding to the greater concentrations of these drugs and their metabolites in urine. The relative importance of various factors affecting the influence of drugs on biochemical test values is discussed.