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Possible role of dopamine in changes in LH and prolactin concentrations after experimentally induced hyperprolactinaemia in rats.

Nine-month-old female rats bearing an ectopic pituitary gland (from a litter-mate) under the right kidney capsule since day 30 of life and their sham-operated controls, were treated with a dopamine agonist (lysuride) or antagonist (metoclopramide). Plasma prolactin and LH levels were measured by double-antibody radioimmunoassays. Vaginal smears were taken before and during the treatment periods. Eight months after the operation, a significant (P less than 0.01) increase in basal prolactin levels together with a significant (P less than 0.05) reduction in LH values and permanent dioestrus occurred in the grafted animals when compared with controls. Lysuride treatment resulted in a marked reduction in plasma prolactin levels both in control and grafted rats over the whole 12 days of treatment, together with a partial restoration of plasma LH levels on day 1. From day 7 onwards a depression in LH values was again observed. Oestrous cycles were partially restored at the beginning of the treatment, but after 7 days dioestrus returned. Metoclopramide administration induced a significant (P less than 0.001) increase in basal prolactin levels in both grafted and control rats. Basal plasma LH values were unaffected in controls when compared with vehicle-treated animals. An increase could be seen in hyperprolactinaemic rats after 7 or 12 days of treatment however. The LH response to the administration of LH releasing hormone (LHRH) was greater in the experimental and control metoclopramide-treated rats when compared with vehicle-treated rats.(ABSTRACT TRUNCATED AT 250 WORDS)