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Detection of SERPINB7 mutation can distinguish Nagashima‐type palmoplantar keratoderma from other keratodermas with palmoplantar lesions

cell transformation. To our knowledge, ours is the first reported case of successful alitretinoin response in MF with CD30-positive large cell transformation. In conclusion, we report a patient with MF with CD30positive large cell transformation, successfully treated with alitretinoin. The drug appears to be a sound alternative in treating intractable MF with large cell transformations. However, further clinical studies are required to confirm the validity of alitretinoin in treating this condition.