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HISTAMINE INDUCES THE ACTIVITY OF METALLOPROTEINASES IN TISSUE OF PATIENTS WITH CERVIX UTERINE CANCER

It is well known that the proteases, as metalloproteinases and urokinase, are involved in the process of degradation of basement membrane and extracellular matrix in tumoral tissue. Histamine is a chemical messenger that acts as a growth factor or chemio‐attracting. At present the role of histamine in cancer is not clear.