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Bisphosphonates Incorporated on a Ca-P Biomimetic Coating Produced by a Sodium Silicate Based Methodology Stimulate Osteoblastic Activity

In the present study sodium clodronate, a well known therapeutic agent from the family of bisphosphonates (BP) was incorporated in an apatite coating, previously formed on the surface of a starch based biomaterial by a sodium silicate methodology, as a strategy to develop a site-specific drug delivery system for bone tissue regeneration. The effects on the resulting apatite coatings were evaluated in terms of morphology, chemistry and structure. As a preliminary approach, this first study aimed at evaluating also the effects of this BP on the viability, growth and function of a human osteoblast cell line, since there is still little information available on the interaction between BPs and this type of cells.