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Contribution of PARP to endothelial dysfunction and hypertension in a rat model of pre‐eclampsia

BACKGROUND AND PURPOSE Under conditions of increased oxidative stress, such as pre‐eclampsia and diabetes, overstimulation of PARP leads to endothelial dysfunction. Inhibition of PARP has been demonstrated to reverse the vascular dysfunction associated with diabetes in vivo. The present study was carried out to investigate the role of PARP in mediating the endothelial dysfunction associated with pre‐eclampsia.