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Expression of bcl -2,p53 and p21 Gene Proteins,and Their Significances in Hepatocellular Carcinoma

Objective:To study the status and significances of bcl 2,p53 and p21 gene expression in hepatocellular carcinoma(HCC).Methods:The samples resected from 55 cases of hepatocellular carcinoma and nodular liver cirrhosis were detected with the antibodies against bcl 2,p53 and p21 in the S P immunohistochemistry study.The relationships between the expression rate and pathological grades and prognosis were analyzed.Results:The positive expression rate of bcl 2 gene protein in HCC and nodular liver cirrhosis were 72.7%(40/55) and 36.4%(20/55) respectively,both present disparity( P 0.05).The positive expression rate of p53 protein in HCC was 54.5%(30/55),the negative expression of all nodular liver cirrhosis tissues was found,both present striking disparity ( P 0.01).The positive expression rate of p21 protein in the HCC and nodular liver cirrhosis were 63.6%(35/55) and 38.2% (21/55) respectively,both not present disparity ( P 0.05).The expression rate and expression intensity of bcl 2、p53 and p21 was not associated with pathological grades in the HCC ( P 0.05). In addition,together expression rate of bcl 2、p53 and p21 in the follow up patients (16 cases) was 50%(8/16).Conclusion:The results suggest that the occurrence of HCC has a close relation with the over expression and mutation of bcl 2、p53 and p21 gene proteins.There may be a joint action among these genes.Because the expression of bcl 2、p53 and p21 can reflect the differential and proliferative degrees of tumour cells,it can be used as the indicators in the diagnosis and prognosis of HCC.