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Clinical efficacy of an endodontic antiseptic in a controlled release delivery system.

The purpose of this clinical study was to assess the bacteriological status of the root canal after disinfection with a quaternary ammonium compound in a controlled release delivery system. Fifty-three teeth with apical periodontitis as evidenced by periapical radiolucencies were used. Under aseptic conditions the root canals were completely instrumented and irrigated with sodium hypochlorite. After the instrumentation, 38 teeth were treated with the quaternary ammonium compound in the controlled release dispenser; 15 teeth were treated with formocresol. Bacteriological samples from the root canals were taken after 7 days using an anaerobic technique. The results indicated that the quaternary ammonium compound in controlled release was as effective as formocresol in obtaining bacteria-free root canals. The advantages of an antiseptic with a long lasting effect for the elimination of bacteria from the root canal and for the prevention of reinfection were emphasized.