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[Cell interactions in the extracellular matrix in tumoral invasion in mammary pathology].

Tumoral invasion in breast lesions is associated with a progressive loss of the basement membrane (BM) components. In situ hybridization reveals a loss of synthetic ability of type IV collagen by invasive cells in a murine model. The loss of BM components does not seem related to the expression of the plasmin system by cancer cells. By contrast, there is a cooperation between fibroblasts and cancer cells for the expression of matrix metallo-proteinases involved in BM degradation in breast carcinomas in vivo.