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Natural history of untreated squamous cell carcinoma of the head and neck

The natural history of untreated head and neck squamous cell carcinoma (SCC) was not well defined. A total of 206 patients with untreated head and neck SCC were retrospectively enrolled. The 1-year survival rate for cancers arising in oral cavity, oropharynx, throat, and hypopharynx was 31%, 20%, 0%, and 3%, respectively, the difference was significant (p<0.001). 57.2% of the patients died within 12 months, median survival time was 11 months. The prognosis of untreated head and neck SCC patients is extremely unfavorable. T stage is the strongest predictors for the survival time. This article is protected by copyright. All rights reserved.