{'fraction_non_alphanumeric': 0.0696774193548387, 'fraction_numerical': 0.06322580645161291, 'mean_word_length': 4.5, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 1, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
PULMONARY FUNCTION STUDIES FOLLOWING BILATERAL LUNG LAVAGE IN PREMATURE LAMBS

The effect of bilateral lung lavage with FC-80 fluorocarbon on pulmonary function was studied in 7 premature lambs, 134 days gestation. The lambs were mechanically ventilated (FIO2 = 1.0)and had arterial and venous catheters. Measurements of transpulmonary pressure, air flow, tidal volume, and functional residual capacity (FRC) enabled calculations of lung compliance (CL,), specific compliance (CS), inspiratory (RI) and expiratory (RE) resistance, and work of breathing (W). Following baseline measurements the lambs were lavaged with warm (39°C) FC-80 liquid (PO2>500 mm Hg). The liquid was removed by postural draining, and pulmonary function was monitored for 1 hour. Mean control measurements were as follows: CL - 0.89±0.18 SE ml/cm H2O/Kg; CS = 0.044±0.009 SE ml/ cm H2O/FRC; FRC = 23.0±4.3 SE ml/Kg; RI = 44.5±8.3 SE cm H2O/1/sec; RE = 105.1±17.4 SE cm H2O/l/sec; W = 78,000±32,000 SE erg/%; PaO2 = 317±45 SE mm Hg; PaCO2 = 26±7 SE mm Hg; pH - 7.46±0.07 SE. Immediately post-lavage, CL, decreased significantly by 43% from control values and RI, RE, W, PaCO2 and pH did not change significantly from pre-lavage values. These data indicate that adequate PaO2 levels can be maintained in premature lambs during and after bilateral FC-80 lavage with relatively small changes in lung mechanics. Pulmonary lavage with FC-80 may prove feasible as a method for alveolar debridements such as in aspiration syndromes. (Supported by USPHS Grants #HL 19402 and #HL 15061)