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Medical applications of laser-induced fluorescence: pharmacokinetics of photosensitizers

Laser-induced fluorescence has been used to measure tissue levels of chloroaluminum phthalocyanine tetrasulfonate versus time in order to determine its pharmacokinetics. A hamster cheek pouch carcinoma model was used in vivo. The data have been modeled using a four compartment pharmacokinetic model, yielding rate constants which describe the transport. A minimum of 13 rate constants was needed to achieve acceptable fits to the tumor and normal tissue as well as plasma data. The model gives insight into the role of binding and unbinding processes that are not otherwise evident.