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[Effects of p,p'-DDE on intracellular MAPK pathway of rat Sertoli cells in vitro].

OBJECTIVE
To study effects of p,p'-DDE on intracellular p-ERK of rat Sertoli cells in vitro.


METHODS
We cultured Sertoli cells separated from testicular tissue of rats and examined the changes of intracellular p-ERK, using immunohistochemical SABC method.


RESULTS
It was showed that intracellular p-ERK increased with the dose of p,p'-DDE and had a dose-dependent trend.


CONCLUSION
The results suggested that p,p'-DDE could result in the phosphorylation of ERK and induce the activation of the downstream road and the transcription and expression of genes.