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Correlation between the characteristics of ultrasonic contrast and the regional distribution of tumor vascular heterogeneity in breast cancer

Breast cancer (BC), one of the most common malignant tumors in women, is characterized by breast mass and the abnormal changes of nipple and areola in clinical (Lambertini et al., 2018). The occurrence and development of BC are a progressive process of multi-factor, multi-stage, multi-gene changes (Liu et al., 2009). BC is highly heterogeneous, and the prognosis of patients with the same clinical manifestations is very different. The prognostic factors determine the biological behavior of breast cancer, which further determine the histopathological changes (Zheng et al., 2019). The tumor microenvironment of breast cancer is composed of a variety of stromal cells, cytokines, chemokines and tumor stromal neovascularization, which is mainly manifested by malignant stroma and tumor vascular heterogeneity (Soysal et al., 2015).