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Evaluation of Daytime Growth Hormone Secretory Dynamics for the Diagnosis of GH Deficiency

Night-time (1,2) and/or 24-hour profiles of growth hormone (GH) secretion (3-5) have been evaluated as investigative tools for the assessment of endogenous G H secretion. From the study of 24-hour profiles of G H secretion, it appears that there are spontaneous G H secretory patterns even during the daytime. Therefore, daytime G H secretory dynamics were investigated in growth retarded children, to determine whether such an analysis could become a useful tool in the same way as night-time GH secretory dynamics.