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Cationic Derivatives of Polyisoprenoids and Commercial Lipid‐Based DNA Carriers for Transfection in vivo in Spontaneously Hypertensive Rats

Development of efficient vectors for transfection constitutes a major challenge in modern gene therapy. Viral vectors are considered more effective, but plagued by safety concerns. Research shows that derivatives of polyisoprenoid alcohols (trimethylpolyprenylammonium iodides, called PTAI), may serve as lipofectants. In previous research PTAI were proved to be effective as DNA carriers in vitro and in vivo as carriers of DNA vaccines against influenza virus.