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Optimal medical therapy vs CT angiography screening for patients with diabetes.

discretion of the clinician. The primary end point was the composite outcome of all-cause mortality, nonfatal myocardial infarction, and hospitalization for unstable angina. At a mean follow-up of 4 years, the primary end point occurred in 6.2% of patients (28 events) in the CCTA group and in 7.6% patients (34 events) in the control group (HR, 0.80 [95% CI, 0.49-1.32]; P = .38). Follow-up was 99% complete. Abnormal findings on CCTA in the patients randomized to imaging was associated with subsequent cardiac events, consistent with previous literature. The negative results of this trial will be disappointing to