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Transcriptome profiling of 6-OHDA model of Parkinson’s disease

Analysis 
of monogenic forms and candidate genes of Parkinson’s disease (PD) does not 
allow to describe completely the contribution of genetic factors to the 
etiopathogenesis of the disorder. An approach associated with an analysis of 
changes in a transcriptome pattern during the development of the disease in 
model objects can be used to identify new candidate genes that are involved in 
the pathogenesis of PD. In this work, we performed a transcriptome analysis of 
a PD model, created via stereotaxic unilateral introduction of the 
6-hydroxidopamine (6-OHDA) into the substantia nigra pars compacta (SNpc) of a 
rat brain, to identify new candidate genes for PD. We studied transcriptome alterations 
in the substantia nigra of the rat brains 2 weeks after toxin administration, 
when the rats developed the Parkinson-like phenotype, and 4 weeks after toxin 
administration, when maximal changes in the behavior of animals were observed. 
The transcriptome analysis of the substantia nigra of the rat brains at the 
first time point (2 weeks) revealed changes in expression of genes that were 
clustered with high significance (p