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Hallucinations after a therapeutic dose of benzodiazepine hypnotics with co‐administration of erythromycin

Abstract A case of repetitive hallucinations during treatment with a therapeutic dosage of triazolam (0.25 mg/day) and nitrazepam (5 mg/day) is presented. The patient suffered from acute pneumonia and chronic renal failure. Such non‐psychotic symptoms as anxiety, tremor and depressed feeling were observed initially. However, after co‐administration of erythromycin (600 mg/day), visual hallucinations and abnormal bodily sensations developed repeatedly after each administration of triazolam or nitrazepam. This report suggests that benzodiazepine hypnotics even at a therapeutic dosage with co‐administration of erythromycin causes serious psychotic symptoms in vulnerable patients with physical complications.