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Lipid droplets help anti-TB drug efficacy

Microbiology
Improving chemotherapies against intracellular pathogens requires understanding how antibiotic distribution within infected cells affects efficacy. Greenwood et al. developed an approach to visualize antibiotics in human macrophages infected with the tubercle bacillus (see the Perspective by Smith and Aldridge). They showed that the antitubercular (anti-TB) drug bedaquiline accumulated in host lipid droplets. Lipid droplets seemed to act as an antibiotic reservoir that could be transferred to bacteria during host lipid consumption. Indeed, alterations in host lipid droplet content affected the anti-TB activity of bedaquiline against intracellular bacilli.

Science , this issue p. [1279][1]; see also p. [1234][2]

 [1]: /lookup/doi/10.1126/science.aat9689
 [2]: /lookup/doi/10.1126/science.aay0211