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Cine-MR Fourier Phase Imaging for Quantification of Regional Wall Asynergy in Patients With Anterior Myocardial Infarction

Purpose The aim of this study was to evaluate whether Fourier analysis of cine-MR could detect wall motion abnormalities in patients with myocardial infarction. Methods Ten patients with anterior myocardial infarction (seven men and three women; mean age, 58 ± 16 years) were compared with six control subjects (four men and two women; mean age, 49 ± 24 years). Gradient echo cardiac cine-MR slices were transformed using a commercially available Fourier algorithm to obtain phase angles of endocardial segments. Mean phase angle and phase dispersion (i.e., SD around the mean) were calculated. Segmental wall motion was evaluated using a 16-segment model and correlated to Fourier phase analysis. Results Mean phase angle and phase dispersion were increased in patients compared with control subjects (respectively, 191° ± 23° vs. 161° ± 25°, P < 0.0001 and 21° ± 10° vs. 11° ± 8°, P = 0.0007). Analysis of variance showed a significant increased dispersion on basal slices (P = 0.002) mostly due to flow-void and entry slice phenomenon. Conclusions Fourier phase analysis of cardiac cine-MR is feasible and allows the evaluation of ventricular asynergy on the basis of endocardial wall motion.