{'fraction_non_alphanumeric': 0.030100334448160536, 'fraction_numerical': 0.010869565217391304, 'mean_word_length': 5.3, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Pineal parenchymal tumors: case series and review

Background: Pineal parenchymal tumors (PPTs) are uncommon tumors comprising of pineocytoma (PC), pineal parenchymal tumor of intermediate differentiation (PPTID) and pineoblastoma (PB). Morphological sub typing and histological grading based on mitotic index and neurofilament (NF) immunostaining, are the factors affecting the survival of these patients. Treatment strategy and prognosis of PPTIDs remain controversial with limited data available on pathological features and biological behavior of PPTID. Case series: A series of 8 pineal parenchymal tumors over a period of 5 years are reported here with special reference to PPTIDs. The series includes 3 cases of PC, 2 of PPTID and 3 of PB. Patients underwent decompression, microsurgical/ stereotactic/ endoscopic biopsy. Histological features with MIB1 LI (labelling index) and NF immunostaining were studied and showed varied presentation. One case in each group of PC and PPTID showed ganglion like cells. Both PPTIDs showed 8% and 20% MIB1 LI. All PBs showed brisk mitosis hemorrhage and necrosis except for one case where mitosis was not clearly evident but showed high MIB1 LI (50%).