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THE EFFECT OF CREATINE AS DIETARY SUPPLEMENT ON GENOMIC INSTABILITY OF MONONUCLEAR CELLS OF PERIFERAL BLOOD AND HEPATOCYTES OF RATS IMPACTED BY X-RAY RADIATION

The effect of creatine (Cr) as a dietary supplement (creatine monohydrate in a 0.9% glucose solution per os at the 1g/kg of rat weight dosage, for two weeks prior to and two weeks after the irradiation) on the post-radiation DNA damage of peripheral blood mononuclear cells and the distribution disorders per rats’ hepatocyte ploidy, induced by the total one-time irradiation in the dosage of 4,5 and 6.5 Gy, has been studied. The results have demonstrated that Cr has a protective effect per the parameters observed, which helps reduce the radiation-induced genomic instability of the respective cells, thus testifying to the radioprotective activity of Cr.