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Direct Detection of 8‐Oxo‐Deoxyguanosine Using UV Resonance Raman Spectroscopy †

8‐oxo‐deoxyguanosine (8‐oxo‐dG) is a major oxidative lesion in DNA and is responsible for mutation and cancer. Current techniques for detecting 8‐oxo‐dG are indirect methods. Thus, development of new methodologies is needed to directly detect such oxidative lesions. In this article, we have used ultraviolet resonance Raman (UVRR) spectroscopy as a novel analytical technique for the detection of 8‐oxo‐dG. Here, the UVRR spectrum of 8‐oxo‐dG was acquired and compared to that of deoxyguanosine (dG) and deoxyadenosine (dA). Data analysis shows a distinct UVRR spectrum of 8‐oxo‐dG with characteristic peaks. Detection of 8‐oxo‐dG was easily achieved from a mixture with dG. These results reveal that UVRR spectroscopy shows promise as a direct method for detecting 8‐oxo‐dG.