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Granulocyte‐colony stimulating factor enhances the expression of transforming growth factor‐β mRNA in CD4‐positive peripheral blood lymphocytes in the donors for allogeneic peripheral blood stem cell transplantation

The degree of acute graft‐versus‐host disease (GVHD) after allogeneic peripheral blood stem cell transplantation (allo‐PBSCT) has been observed to be, unexpectedly, of an equal level to that after bone marrow transplantation. To explain this phenomenon, we hypothesized that granulocyte‐colony stimulating factor (G‐CSF) administration may induce transforming growth factor (TGF)‐β producing T cells in the donors. Five donors received 10 μg/kg G‐CSF subcutaneously for 4 days. The TGF‐β mRNA expression in CD4+ cells as measured by real time reverse transcription‐polymerase chain reaction increased after G‐CSF administration. This elevation is considered to be one additive mechanism of repression of acute GVHD after allo‐PBSCT. Am. J. Hematol. 69:138–140, 2002. © 2002 Wiley‐Liss, Inc.