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Acute febrile neutrophilic dermatosis (Sweet's syndrome) and adenocarcinoma of the rectum

Sweet's syndrome is a distinctive dermatosis that usually occurs as an idiopathic disorder. About 10% of cases have occurred in patients with myeloproliferative disease. Seven cases have been described with Sweet's syndrome in conjunction with a solid malignancy. We report a patient with Sweet's syndrome in association with an adenocarcinoma of the rectum. We believe that this syndrome may reflect a clinical manifestation of underlying myeloproliferative or solid malignancy.