{'fraction_non_alphanumeric': 0.0171990171990172, 'fraction_numerical': 0.022113022113022112, 'mean_word_length': 5.12781954887218, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
miR-495 Mediates Metabolic Shift in Glioma Cells via Targeting Glut1

AbstractCancer cell metabolism is often characterized by a shift from an oxidative to a glycolytic bioenergetics pathway, a phenomenon known as the Warburg effect. Whether the deregulation of microRNAs contributes to the Warburg effect remains largely unknown. Here, we show that miR-495 expression is decreased and thus induces a metabolic shift in glioma cells. miR-495 performs this function by increasing the expression of Glut1, leading to the increase of glucose uptake and lactate production. The altered metabolism induced by miR-495 results in the rapid growth of cancer cells. These results identify miR-495 as a molecular switch involved in the orchestrationofthe Warburg effect in glioma cells via targeting the expression of Glut1.