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Advanced glycation end products downregulate glucokinase in mice

Glucokinase, the enzyme that catalyses the conversion of glucose to G‐6‐P, plays a key role in glucose metabolism. AGEs are implicated in diabetic complications. A previous study reported that AGEs decreased β‐cell function through inhibition of cytochrome c oxidase and adenosine triphosphate synthesis. This study investigated the effects of AGEs on glucokinase and islet function.