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Stability of Pentobarbital in Water and Oral Pediatric Suspensions

To ensure motionless conditions during computed tomography or magnetic resonance imaging in infants, sedative drugs could be used but with the potential risk of adverse effects such as respiratory depression. Pentobarbital sodium (Nembutal) and chloral hydrate are the more frequently used drugs. Clinical studies reported the effectiveness of pentobarbital sedation and a decreased rate of adverse events as compared with chloral hydrate for imaging sedative procedures. Pentobarbital is usually administered to infants at the dose of 4 to 5 mg/kg, with a maximum of 8 mg/kg. Nembutal is not available in the United States and Europe, and some hospital pharmacy units prepare rectal or oral forms. To facilitate its administration, we chose to study pentobarbital sodium stability in water and compounded in 5 suspensions.