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Effect of Trigona honey on Blood glucose levels Diabetes Mellitus In Balb/c Mice

Introduction Diabetes Mellitus (DM) is a multicultural metabolic disease characterized by hyperglycemia due to abnormalities in insulin secretion, insulin action, or both. Abnormalities in insulin secretion or action cause problems in the metabolism of carbohydrates, fats, and proteins. DM Type II is characterized by the occurrence of insulin resistance in body tissues. Trigona honey is rich in phenolic compounds because it is food collected by bees from plants. The total phenolic content in honey is highly correlated with antioxidant activity. In this study, we aimed to see the different effects of trigona honey (Tetragonula sp) on plasma insulin and blood glucose levels in mice with diabetes mellitus. Methods. Balb/c mice (n= 28) were randomly assigned into the control group (n=7), negative control, positive control, and intervention group which received a daily intake of trigona honey (n= 14). Results. showed that administration of trigona honey can increase administration of the metformin. This is caused because honey contains high antioxidants and contains bioactive compounds such as alkaloids, flavonoids, triterpenoids, and phenol compounds. Conclusion. Daily consumption of trigona honey has a remarkable potential to decrease the blood glucose, thus it can contribute to the prevention of the diabetes mellitus development.