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Modulation of Mononuclear Phagocyte Cytotoxicity by Alpha‐Tocopherol (Vitamin E)

The in vitro effect of colloidal suspensions of alpha‐tocopherol (α‐T) on phorbol‐ myristate‐acetate (PMA)‐induced monocyte cytotoxicity and on antibody‐dependent monocyte cytotoxicity (ADCC) was studied. We observed that 1) in the presence of α‐T, the inhibition was twice as high in the PMA‐induced assay than in ADCC; 2) monocytes preincubated with α‐T were inhibitory in both assays but much less in ADCC, and 3) target erythrocytes preincubated with a‐T decreased the cytotoxicity in the PMA‐induced assay only. Since α‐T preincubated monocytes showed a decreased release of H2O2 but not of O2″, we concluded that one of the mechanisms by which α‐T decreased cytotoxicity could be decreased release of H2O2. Whereas the role of H2O2 was documented in the PMA‐induced cytotoxicity, in ADCC non‐oxidative injury seems more important. This is supported by 1) lesser inhibition of the assay with α‐T preincubated monocytes; 2) lack of protection with α‐T preincubated erythrocytes, and 3) mild inhibition with protease inhibitor.