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Seroreactivity to Microbial Antigens and Gut‐Homing Immune Responses in Functional Dyspepsia Patients with Postprandial Distress Syndrome

Functional dyspepsia (FD) is characterised by recurrent upper gastrointestinal symptoms with no explainable structural changes seen at endoscopy. FD can be classed by two symptom‐based subtypes: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). Although FD is associated with an altered microbiome, the nature and consequence of the host‐microbiota interactions and how they relate to FD symptom subtypes is not well understood. We have previously identified an increase in the abundance of Streptococcus spp. in the duodenal microbiota of FD patients compared to controls (Zhong et al. 2017 Gut). We hypothesised that the microbiota of FD patients influenced immune homeostasis and aimed to investigate whether specific species provoked immune responses in patients with FD.