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Biochemical studies on RNA tumor virus information and its transmission in B16 murine melanoma

The mouse melanoma B16 contains particles encapsulating a high molecular weight RNA of 60–70S size associated with a reverse transcriptase. The particles possess a density of 1.14–1.18 g/cm3. The RNA shares sequences with the 70S RNAs of several mammalian C‐type RNA tumor viruses. The nuclear DNA of the mouse melanoma B16 possesses particle‐related sequences not present in the genome of normal C57BI mice.