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Response Entropy™ is not more sensitive than State Entropy™ in distinguishing the use of esmolol instead of remifentanil in patients undergoing gynaecological laparoscopy

Background:  Monitoring of analgesia remains a challenge during general anaesthesia. Activation of Response Entropy™ (RE) to painful stimuli has been suggested to be a sign of inadequate analgesia. We evaluated the ability of RE to be more sensitive than State Entropy™ (SE) in measuring nociception in patients undergoing gynaecological laparoscopy. Our hypothesis was that while keeping SE at a predetermined level, RE would be higher in patients receiving a beta‐blocking agent (esmolol) instead of an opioid (remifentanil) during a propofol/nitrous oxide anaesthesia.