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Live Animal Imaging of Calcium Signaling During Transendothelial Migration Demonstrates Tight Temporospatial Regulation Coordinated by Endothelial Cell TRPC6, IQGAP1, and CaMKIIδ

Proper regulation of inflammatory cell recruitment is critical to fighting infection and maintaining organism homeostasis. Misdirected inflammation can exacerbate pathology and underlies the pathology of virtually all diseases including arthritis, atherosclerosis, and multiple sclerosis. The transendothelial migration (TEM) of leukocytes out of the bloodstream and into tissue is the rate‐limiting and putative committed step of the inflammatory process. As such, the regulation of TEM represents a key target for potential therapeutic intervention.