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Relapsing polychondritis complicated with Sweet’s syndrome and normolipemic neutrophilic xanthomatosis successfully treated by dapsone

Relapsing polychondritis is a rare disorder characterized by recurrent episodes of inflammation and degeneration of cartilaginous tissues. Sweet’s syndrome is characterized by recurrent painful inflammatory papules, fever, leukocytosis, diffuse neutrophilic infiltrate, and good response to systemic glucocorticoids. Normolipemic xanthoma is defined by xanthoma identified in a normolipemic patient. We report a patient with normolipemic neutrophilic xanthomatosis, Sweet’s syndrome, and relapsing polychondritis that improved rapidly with dapsone. A 70-year-old man had yellowish papules on his chest and abdomen two years after the onset of relapsing polychondritis (Fig. 1a). Histopathologic examination of a skin biopsy specimen demonstrated foamy cells in the