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EFFECT OF TEMPERATURE ON CHANGES, INDUCED BY OESTRUS, in α‐ AND β‐ADRENOCEPTOR ACTIVITIES OF THE RAT UTERUS

The α‐ and β‐adrenoceptor activities of the isolated rat uterus during the oestrous cycle were influenced greatly by temperature changes. During dioestrus, lowering the bath temperature to 25° C from 40° C increased two‐fold the inhibition produced by (–)‐adrenaline, (–)‐noradrenaline, (–)‐phenylephrine and (–)‐isoprenaline. During oestrus adrenaline, noradrenaline and phenylephrine produced biphasic responses of contraction followed by inhibition at 40° C and isoprenaline produced only inhibition. At 25° C the contractile α‐responses either were abolished (phenylephrine) or greatly reduced (adrenaline and noradrenaline), while the inhibitory β‐effects of all four amines were increased.