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Three-Dimensional Reconstruction and Quantification of PGP9.5-Immunoreactive, Sensory Intra-Epidermal Nerve Fibers

Intra-epidermal nerve fibers (IENFs) are the peripheral component of primary sensory neurons and are the anatomical attributes for an organism’s ability to sense the environment, i.e., tactile, temperature stimuli. These small, unmyelinated, IENFs also transmit protective noxious information critically important to the survival of an organism. Decrease of IENFs within peripheral tissue may indicate potential disease. Several life-threatening peripheral neuropathies, such as autoimmune diseases and diabetes, can be assessed with a skin biopsy. Modern skin biopsy techniques involve removing a small portion of skin to evaluate IENF density and branching. It has been reported that IENF swelling, decrease in IENF density, increased branching, and morphological fragmentation of intra-epidermal nerves may indicate potential disease [1].