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Electroporation‐mediated interleukin‐10 overexpression in skeletal muscle reduces acute rejection in rat cardiac allografts

Human interleukin 10 (hIL‐10) may reduce acute rejection after organ transplantation. Our previous data shows that electroporation‐mediated transfer of plasmid DNA to peripheral muscle enhances gene transduction dramatically. This study was designed to investigate the effect of electroporation‐mediated overexpression of hIL‐10 on acute rejection of cardiac allografts in the rat.