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Knockdown of ANGPTL2 promotes cardiac left ventricular dysfunction in mice via up‐regulation of NOX4

Angiopoietin‐like 2 (ANGPTL2) is a pro‐inflammatory and pro‐oxidative glycoprotein that induces vascular endothelial dysfunction in mice and promotes atherosclerosis. Higher circulating levels of ANGPTL2 have been reported in patients with heart failure, but the potentially deleterious effect of ANGPTL2 on cardiac function is ill defined. Our aim was to investigate the cardiac function of adult mice knockdown for angptl2 (KD mice).