{'fraction_non_alphanumeric': 0.029114645391907994, 'fraction_numerical': 0.00828886701548982, 'mean_word_length': 5.294098467557874, 'pattern_counts': {'":': 0, '<': 3, '<?xml version=': 0, '>': 1, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
PRINCIPI LEČENJA PRELOMA KARLICE KOD POLITRAUMATIZOVANIH PACIJENATA PRINCIPLES OF PELVIC FRACTURE TREATMENT IN POLYTRAUMA PATIENTS

Introduction: The treatment of pelvic fractures is one of the biggest challenges in orthopedic surgery and traumatology. Mortality from these injuries can be as high as 21%, which is why recognizing them and providing adequate treatment is of great importance. The most common cause of death in the first 24 hours following injury is bleeding. Pelvic fractures range from simple to complex fractures with consequent hemodynamic instability. The aim of this study is to assess current standards of pelvic fracture care, as well as to indicate a possible strategy to improve the final outcome of treatment. Results: When there is no established protocol, the on-duty team of doctors is guided by the guidelines available to them. More recently, DCR has been considered a guiding principle in the care of polytraumatized patients. It is of primary importance to establish bleeding control – using PPP, angiographic embolization or the REBOA method. The use of pelvic bandages is recommended in literature as the primary form of care for pelvic injuries by the emergency service or by a trained person in pre-hospital conditions. External fixation of unstable pelvic fractures is one of the key steps in the DCR protocol. ORIF of pelvic fracture is a definite type of fracture fixation, but it is performed only in hemodynamically stable patients. Conclusion: Due to the anatomical characteristics of the pelvic cavity, pelvic ring injuries represent only a part of the spectrum of polytrauma, therefore the treatment is initially based on the hemodynamic stabilization of the patient (DCR protocol). The treatment of such patients requires a multidisciplinary approach. Placement of an external fixator as part of the DCO protocol has a role in bleeding control and is the method of choice in hemodynamically unstable patients. Definitive pelvic fracture fixation (ORIF) is performed in hemodynamically stable patients, who are not in life-threatening condition.


INTRODUCTION
Treating pelvic fracture is one of the greatest challenges in orthopedic surgery and traumatology. Pelvic fractures occur as the result of powerful force, primarily in traffic accidents (60%), in falls from height (30%), as well as in shooting and industrial accidents [1]. In a small number of elderly patients, pelvic fracture may occur as the result of the patient falling from standing height, due to osteodystrophic changes in the bone joint system. Bearing in mind that mortality in these injuries can be as high as 21% [2], it is of great importance that they should be recognized and treated adequately and on time. Bleeding is the most common cause of death in the first 24 hours following injury.
Pelvic fractures vary from simple fractures to complex multiple fractures with consequent hemodynamic instability. In polytraumatized patients, pelvic fractures are present in as many as 20% of cases [3]. In treating these patients, a multidisciplinary approach is necessary -a team made up of experienced orthopedic and general surgeons, including also an interventional radiologist and anesthesiologist.
In several studies published so far, it has been noted that, in those centers where an algorithm for treating pelvic fracture in hemodynamically unstable patients has been designed and put into use, a significant drop in mortality has occurred [4][5][6][7].
The aim of this study is to assess the current standards of pelvic fracture treatment, as well as to indicate the possible strategy for improving the final outcome of treatment.

POLYTRAUMA
According to the new Berlin Definition, polytrauma indicates cases with an Abbreviated Injury Scale (AIS) score ≥ 3, for at least two anatomical regions of the body, and with one of the following five physiological parameters, or with a combination of two or more of these parameters: 1. Hypotension (systolic blood pressure ≤ 90 mmHg) 2. Loss of consciousness (Glasgow Coma Scale ≤ 8) 3. Acidosis 4. Coagulopathy (partial thromboplastin time ≥ 40 s) 5. Patient age (≥ 70 years) [8].
In a polytraumatized patient, at least one of two or more injuries is life-threatening.

FIRST STEP IN TREATING PELVIC FRACTURE
The protocol for treating pelvic fracture varies from hospital to hospital. When there is no established protocol, the on-duty team of doctors are guided by available guidelines. As of late, damage control resuscitation principi lečenja preloma karlice kod politraumatizovanih pacijenata principles of pelvic fracture treatment in polytrauma patients (DCR) has been considered the leading principle in treating polytraumatized patients. DCR is a strategy whose aim is to stop bleeding, as well as to prevent or reverse the development of the components of the trauma triad of death -hypothermia, acidosis, and coagulopathy, through a series of combined therapeutic protocols [9].
However, the implementation of this strategy depends on a number of factors -the capacities of the hospital, equipment, the capability of the surgical team to perform damage control surgery, as well as the possibility of performing urgent angiography (blood vessel embolization).
Regardless of the choice of strategy, it is necessary to perform the following: requisite diagnostics (clinical examination, laboratory analyses, X-ray, ECHO, MSCT), assessment of the severity of the injuries, assessment of the need for noninvasive/invasive pelvic stabilization, assessment of possible abdominal injuries, and then reach a decision on the need for surgical treatment and angiography [10].

SOURCES OF BLEEDING
The possible sources of bleeding are arteries, veins, and cancellous bones [11]. It is necessary to determine the source and establish control of the bleeding. In their study, Wijffels et al. stated that in 70 % of cases of hemodynamically unstable patients with pelvic injury and hypotension resistant to resuscitation, arterial bleeding was present [12].
Also, certain types of fractures correlate with injury of certain blood vessels -pubic bone fractures correlate with injury to obturator blood vessels; dislocation of the sacroiliac joint (shear injury) correlates with venous bleeding, primarily from gluteal and hypogastric branches.

ABDOMINAL-PELVIC TOURNIQUETS
The application of abdominal-pelvic tourniquets is recommended in literature as the primary method of taking care of pelvic injuries by the emergency services or by a trained person, in prehospital care. Abdominal-pelvic tourniquets are a noninvasive form of external compression, which has proven useful in the control of bleeding and for temporarily stabilizing the pelvic ring [10].
Abdominal-pelvic tourniquets should be positioned around the great trochanters and the pubic symphysis, so that the pressure applied would lead to temporary stabilization of pelvic fracture, leg adduction, and a decrease of the internal volume of the pelvic cavity.

SPOLJAŠNJA FIKSACIJA PRELOMA KARLICE
Spoljašnja perkutana fiksacija mehanički nestabilne karlice predstavlja jedan od ključnih koraka u sklopu DCR protokola politraumatizovanih pacijenata sa principi lečenja preloma karlice kod politraumatizovanih pacijenata principles of pelvic fracture treatment in polytrauma patients for polytraumatized patients with pelvic fracture. In addition to stabilizing the pelvic ring, the goal in applying this method is also to decrease the volume of the pelvic cavity, in order to bring about the tamponade of venous hemorrhage [13].
Two main principles of external fixation, depending on the type of pelvic fracture, have been described in literature. For rotationally unstable, anteroposterior compression fractures and lateral compression fractures, the method of choice is anterior external fixation. Posterior external fixation (C clamp) is the approach recommended in vertically unstable pelvic fractures, in order to achieve stability of posterior pelvic segments [10,14].
In most cases, external fixation is carried out within the DCR protocol and represents a temporary method for stabilizing the fracture and establishing control of the bleeding, which, however, in a certain number of cases, may be the definitive method of fixation [15]. In such cases, immobilization of the fracture with an external fixator lasts 6 -12 weeks, until clinical and radiographic signs of fracture healing are registered.
In the application of this method, it is necessary that the surgeon is experienced and familiar with the principles of external pelvic fixation, due to the possibility of the development of complications, such as injury to the neurovascular structures caused by inappropriate positioning of the pins, loosening of the fixation and renewed instability, as well as the development of infection at the placement site of the pins.

PREPERITONEAL PELVIC PACKING (PPP)
The primary source of acute retroperitoneal bleeding in hemodynamically unstable patients with pelvic ring injury is attributed to venous bleeding, in 80% -90% of all cases, and it originates from the presacral and paravesical venous plexus, as well as from bleeding from the cancellous bones, due to iliac and sacral fractures and the disruption of the sacroiliac joint, while in 10% -20% of cases the bleeding is of arterial origin [16].
The concept of 'direct' preperitoneal pelvic packing (PPP), as described in Denver, is a special surgical method, wherein a suprapubic incision is made, enabling direct retroperitoneal access, upon which packing is performed [17].
The modified PPP method enables more efficient packing within the hidden retroperitoneal space, wherein three laparotomy pads are placed on each side of the urinary bladder, in such a way as to be packed below the rim of the pelvis and towards the iliac blood vessels, without there being any need to expose the retroperitoneal space [10]. Using this technique, midline laparotomy can be executed through a separate incision, proximally to the suprapubic access, if there are prelomom karlice. Osim što se stabilizuje karlični prsten, cilj primene ove metode je i smanjenje volumena karlične duplje, kako bi došlo do tamponade venskog krvarenja [13].

ANGIOGRAPHIC EMBOLIZATION
Angiographic embolization is a technique whereby synthetic materials, called embolic agents, are injected into an artery via catheter, which results in blood flow blocking in the given region of the body. Arterial bleeding occurs in approximately 10% -15% of all hemorrhages in hemodynamically unstable pelvic injuries, which is usually accompanied by hypotension, resistant to resuscitation or mechanical stabilization [19]. Arterial injuries have an unfavorable prognosis, especially when larger blood vessels are involved. The internal iliac artery is the main source of arterial bleeding in the pelvis (86%), with the greatest number of lesions occurring on its main branch [11]. Indications for angiography are as follows: hemodynamic instability resistant to reanimation, partially responsive patients with CT contrast extravasation, as well as a progressive fall of the hemoglobin level, requiring the transfusion of four or more units of blood [11].

RESUSCITATIVE ENDOVASCULAR BALLOON OCCLUSION OF THE AORTA (REBOA)
Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a percutaneous transfemoral procedure, which includes the placement of an endovascular balloon into the aorta, for the purpose of controlling arterial bleeding and temporarily maintaining blood pressure in traumatic hemorrhagic shock [11,20]. This procedure is highly dependent on a functional approach to the femoral artery, and early implementation of this approach is of the utmost importance. This method has become the alternative for emergency thoracotomy in hemodynamically unstable polytraumatized patients.
REBOA can be performed in Zone 1 (supraceliac aorta or descendant aorta), Zone 2 (pararenal aorta), or Zone 3 (infrarenal aorta). Zone 2 is usually avoided, due to possible visceral organ ischemia. Zone 3 is the optimal approach in pelvic hemorrhage, as it prevents visceral organ ischemia, at the same time enabling a long occlusion time (4 -6 h) [21].

DCO AS A PART OF DCR
After severe trauma, the following three major factors determine the development of clinical presentation: 1. Initial degree of injury ("first hit" -burden of trauma) 2. Individual biological response of the injured patient's body 3. Type of treatment ("second hit" -burden of surgery) [24]. Within the DCR protocol, damage control orthopedics (DCO) also has its place.
DCO is a surgical strategy focused on the following: 1. establishing control of the bleeding -the ABCDE (airway, breathing, circulation, disability, exposure) approach, except in conditions of catastrophic bleeding, when component C is primarily focused on; 2. prevention of soft tissue contamination -wound debridement; 3. early temporary stabilization of the fracture -primarily with external fixation, which is the method of choice as it is expedient and minimally invasive, but also with simpler procedures, such as traction and plaster; 4. stabilization of the patient -requires good communication between the surgical team and the anesthesiologist, as it is the anesthesiologist who has the best understanding of the general status of the patient; all treatment procedures are aimed at achieving the desired values -median arterial pressure > 60 mmHg, pulse < 100, urine output = 0.5 -1.0 ml/kg/h, serum lactates < 2.5, and normal base deficit ( -2 to +2); 5. avoiding 'second hit' and the trauma triad of death [9].
Such an approach minimalizes the duration of the procedure and blood loss; at the same time, it makes patient care easier and provides earlier and better mobility of the patient [25]. It is believed to be the most useful approach for patients with associated head and chest trauma, patients with a high injury severity score (ISS), patients with a predisposition for the development of postoperative complications, as well as for 'borderline' patients [16]. In such polytraumatized patients, undergoing surgery increases the risk of postoperative complications [26]. This approach stems from examples of patient care in cases with abdominal and pelvic trauma, where it has transpired that the strategy of primary bleeding control and secondary revision surgery, with the aim of definitive patient treatment, improves the course of postoperative recovery [27]. syndrome -MODS) usled ishemijsko -reperfuzijske reakcije. Ovaj problem se prevenira kratkotrajnom REBOA procedurom, intermitentnom REBOA procedurom (iREBOA), Zona 3 REBOA procedurom i parcijalnom REBOA procedurom [22,23].
When treatment is carried out according to the principles of DCO, an important issue to consider is the optimal moment for carrying out the secondary procedure.
It is believed that the period of 2 -4 days following injury is not favorable for the second procedure. In this period, immunological changes are still ongoing [29] and generalized edema has as yet not subsided [30]. The results of a large study, which included 4,314 patients, showed that the timing of the secondary operation, which normally lasts more than three hours, may be associated with the development of organ dysfunction. Patients were divided according to the presence or absence of MODS. In patients surgically treated 2 -4 days following trauma, organ failure did occur, while in patients which had a secondary operation between day 6 and day 8, organ dysfunction did not develop (p < 0,0001) [31]. Also, the study showed that, in patients who were operated on earlier, more severe inflammation developed, as compared to patients who were operated on later. Therefore, after DCO, there should be a waiting period of several days before secondary definitive surgery.

OPEN REDUCTION AND INTERNAL FIXATION (ORIF)
Open reduction and internal fixation (ORIF) of pelvic fracture is one of the most complex orthopedic surgical procedures and represents a definitive type of fracture fixation. In polytraumatized patients, open reduction and internal fracture fixation is most often carried out as a second step, after the patient has been completely stabilized, with the aim of providing the best possible functional recovery and minimizing the disruption in the quality of life, as well as minimizing potential invalidity, in case of untreated pelvic fracture [32,33]. While the patient is being stabilized in intensive care, the pelvic fracture remains stabilized with an external fixator.
Depending on the type of fracture, the site of the fracture is accessed using the appropriate approach, open reduction of the fractured fragments is performed, and the fractures are then fixed with the appropriate implantation material -in most cases, with lag screws and with plates. As compared to external fixation, ORIF provides anatomical reduction of fractured fragments and more superior biomechanical stability, as well as faster recovery.
principi lečenja preloma karlice kod politraumatizovanih pacijenata principles of pelvic fracture treatment in polytrauma patients CONCLUSION Pelvic ring injuries mainly occur as the result of powerful force, resulting in injury, not only to the skeletal, but to other body systems as well. These are rarely isolated injuries (in elderly patients, low-energy injuries), and, in most cases, associated injuries of the bone joint system, thorax, abdomen, and/or head are also present. This means that timely and appropriate treatment of these injuries is of vital importance, both at the site of first aid and at trauma centers. Bearing in mind the anatomical features of the pelvic cavity, injuries to the pelvic ring are only one segment of polytrauma, which is why treatment is initially focused on hemodynamic stabilization of the patient (DCR protocol). The treatment of such patients requires a multidisciplinary approach (hemodynamic stabilization, PPP, REBOA). Only when vital functions are stabilized, can doctors proceed to treat other medical issues, which do not primarily threaten the life of the patient.
Placement of an external fixator, within the DCO protocol, has a role in bleeding control, which makes it the method of choice in hemodynamically unstable patients.
Definitive fixation of pelvic fracture (ORIF) is carried out initially in stable patients, whose life is not in danger, or in polytraumatized patients, upon their stabilization. It is an indispensable method of treatment with respect to functional recovery and decreasing the rate of invalidity.
Although the mortality rate in these patients is still high, timely medical assistance and the correct choice and application of treatment methods, reduce the said rate effectively.

LIST OF ABBREVIATIONS AND ACRONYMS
ABCDE -airway, breathing, circulation, disability, exposure -ABCDE approach; approach used in bleeding control DCO -damage control orthopedics DCR -damage control resuscitation; protocol used for hemodynamic stabilization of the patient ISS -injury severity score MODS -multiple organ dysfunction syndrome ORIF -open reduction and internal fixation PPP -preperitoneal pelvic packing REBOA -resuscitative endovascular balloon occlusion of the aorta Conflict of interest: None declared.