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[Changes to IFN-γ and IP-10 in the arterial blood of premature infants before and after mechanical ventilation].

OBJECTIVE
This study examined changes to pro-inflammatory cytokine IFN-γ and chemokine IP-10 in the arterial blood of premature infants before and after mechanical ventilation, with the aim of exploring possible mechanisms of ventilation-induced lung injury.


METHODS
Twenty-three neonates requiring mechanical ventilation were enrolled in this study. Arterial blood samples were collected for measuring IFN-γ and IP-10 levels using ELISA before and 4 hours after mechanical ventilation.


RESULTS
Blood IFN-γ and IP-10 increased significantly from 59 ± 40 pg/mL and 130 ± 67 pg/mL respectively before mechanical ventilation to 105 ± 54 pg/mL and 220 ± 80 pg/mL respectively after 4 hours of mechanical ventilation (P<0.01).


CONCLUSIONS
Serum IFN-γ and IP-10 levels increase after mechanical ventilation, suggesting that both may participate in the immune-inflammatory process of ventilation-induced lung injury.