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Restoration of ion channel function in deafness‐causing KCNQ4 mutants by synthetic channel openers

BACKGROUND AND PURPOSE DFNA2 is a frequent hereditary hearing disorder caused by loss‐of‐function mutations in the voltage‐gated potassium channel KCNQ4 (Kv7.4). KCNQ4 mediates the predominant K+ conductance, IK,n, of auditory outer hair cells (OHCs), and loss of KCNQ4 function leads to degeneration of OHCs resulting in progressive hearing loss. Here we explore the possible recovery of channel activity of mutant KCNQ4 induced by synthetic KCNQ channel openers.