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Post‐ or Pre‐Injury Concentric Contractions Do Not Reduce Eccentric‐Contraction‐Induced Myofiber Damage in a Murine Model of Dysferlin‐linked Muscular Dystrophy

Concentric contractions have been shown to reduce delayed onset muscle soreness following eccentric contractions in healthy human subjects. Dysferlin‐deficient muscle undergoes severe delayed onset myofiber damage over several days after eccentric contractions. The goal of our study was to test the hypothesis that concentric contractions reduce eccentric‐contraction‐induced myofiber damage in dysferlin‐deficient muscle.