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[Vascular endothelial system--from the pathological aspects].

Endothelial functions have been paid much attention in the interaction between blood and vascular wall and their functional aterations play an important role in the development and progression of thrombosis and atherosclerosis. In this paper two topics in these fields, namely, the in vivo expression of tissue factor by endothelial cells as well as macrophages in hepatic sinusoids of rats and rabbits with endotoxemia, and the angiogenic mechanism in atherosclerotic intima of human coronary arteries and its pathophysiological significance, would be reviewed mainly based on our data obtained by immunohistochemical and biochemical examinations and molecular analyses.