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Issue highlights—Clinical Cytometry (Cytometry Part B) January 2012

FUNCTIONAL EFFECTS OF IVIG ON MONOCYTES The authors of this report have previously established their methodology to measure phagocytosis and postphagocytic reaction of cord blood and adult blood monocytes (1). Here Gille et al. provide data on the effect of IVIG on phagocytosis, T-cell proliferation, and apoptosis as assessed by flow-cytometry. They identified important differences in apoptosis rate when monocytes from peripheral blood were compared to that derived from cord blood, since this latter cell type responded more intensely to IVIG regarding apoptosis as detected by functional tests. These findings may be beneficial when assessing the effects of IVIG in neonatal sepsis. This issue of Cytometry B provides three papers related to T-cell analysis in HIV infected patients from different perspectives.