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Fy phenotype and gender determine plasma levels of monocyte chemotactic protein

BACKGROUND: In vitro studies indicate that the Fy blood group system antigens serve as receptors for chemokines such as monocyte chemotactic protein‐1 (MCP‐1) and RANTES. However, it is unclear whether subjects with the Fy(a−b−) phenotype exhibit altered clearance and hence altered plasma levels of chemo‐kines, because they still express Fy on endothelial cells.