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Gadolinium selectively blocks a component of calcium current in rodent neuroblastoma x glioma hybrid (NG108‐15) cells.

1. The effect of the lanthanide cation Gd3+ on voltage‐dependent calcium currents in neuroblastoma x glioma (NG108‐15) cells has been studied using a whole‐cell clamp technique. 2. Gd3+ reduced the amplitude of calcium currents. The amount of inhibition produced by Gd3+ was concentration dependent between about 0.5 and 5 microM and reached a maximum at about 10‐20 microM. 3. A proportion of the total calcium current was resistant to blockade by Gd3+. 4. Gd3+‐resistant calcium current consisted of two components: a rapidly inactivating, 'fast' component which was activated at potentials more positive than about ‐45 mV, and a long‐lasting, 'slow' component which was activated at potentials more positive than about ‐10 mV. 5. It was possible to isolate the slow component, in the presence of Gd3+, by selectively inactivating the fast component with a brief depolarizing pre‐pulse. The fast and slow components of current probably reflect the activity of two subpopulations of calcium channels which are resistant to block by Gd3+. 6. In control conditions inactivation of calcium current could be described by the sum of a fast (tau congruent to 40 ms at +10 mV) and a slow (tau congruent to 800 ms at +10 mV) exponential decay plus a constant. Gd3+ selectively blocked the slowly decaying current. 7. The current blocked by Gd3+ was activated at potentials more positive than about ‐35 mV and decayed monoexponentially (tau congruent to 800 ms at +10 mV). 8. It is concluded that under the experimental conditions used in the present study calcium currents recorded in NG108‐15 cells are made up of at least three components which reflect the activity of three distinct subpopulations of calcium channels, one of which is selectively blocked by Gd3+.