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Granulosa cell tumor arising in the ovary irradiated 22 years earlier for endometrial stromal sarcoma.

We encountered a rare case of metachronous tumors in a 57-year-old Japanese housewife who presented with an ovarian granulosa cell tumor 22 years after receiving treatment for endometrial stromal sarcoma. Treatment consisted of a total abdominal hysterectomy and left salpingo-oophorectomy followed by 40 Gy whole abdominal irradiation. Since the second tumor occurred in the ovary that had been previously irradiated to treat the first metachtonous neoplasm, the present case can help to improve our understanding of the histogenesis of granulosa cell tumors.