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Successful Hand Replantation in a Case of Total Avulsion without Vein Graft

Summary: Replantation is the reattachment of a severed body part, with attempts to restore neurovascular and musculoskeletal integrity, function, and aesthetics. On September 7, 1964, the first extremity replantation—a completely amputated hand—by vascular anastomosis technique was successfully performed.1 Soon after, the first replantation of a complete thumb amputation using microvascular anastomosis in a human was successfully conducted by Komatsu et al.2 in 1968. The overall success rate of limb replantation surgery is around 83.2%.3 The mechanism of injury plays a role in the outcome; guillotine amputations—for example—carry a better prognosis than crush amputations.4 We present a case report of a 36-year-old male patient who presented with a total avulsion of the right hand with multiple fracture levels at the level of trans-carpal, distal radius extra-articulation fracture, and total avulsion of the hand. The patient was managed by a multidisciplinary team who were able to reattach his hand successfully with good functional outcome.

the tendons avulse from common flexor and extensor origin, and the vessels and nerves suffered at the level of mid-forearm (Fig. 1). The stump was seemed to be physiological degloving injury, contusion wound with skin loss over cubital fossa, contaminated with oil and dust of the machine (Fig. 1).
The patient was booked for urgent replantation surgery. Preoperative laboratory studies including a complete blood count, cross matching, complete metabolic panel, coagulation profile, and an x-ray of the right hand were ordered (Fig. 2). The patient was started on IV infusion Piperacillin/Tazobactam 4.5 g q8/h for 10 days and oral Clindamycin 450 mg bid for 10 days. The surgery was performed under general anesthesia with an axillary nerve block. The total time of the operation was 7 hours.
The procedure began with the plastic surgeons debriding and exploring the ulnar artery, radial artery, median nerve, and ulnar nerve on both the proximal and distal stumps using vessels loops and clamps. The orthopedic surgeons then proceeded with osteosynthesis, which took 1.5 hours to accomplish. An open reduction and internal fixation of the distal radius and styloid process with size 2.0 K-wires was performed. Next, trans-carpal fixation with a total of six 2.0 K-wires was performed (Fig. 3).
Finally, the flexor and extensor tendons were repaired with Prolene 3.0, and the muscles were repaired with Vicryl Rapide 3.0. Summary: Replantation is the reattachment of a severed body part, with attempts to restore neurovascular and musculoskeletal integrity, function, and aesthetics. On September 7, 1964, the first extremity replantation-a completely amputated hand-by vascular anastomosis technique was successfully performed. 1 Soon after, the first replantation of a complete thumb amputation using microvascular anastomosis in a human was successfully conducted by Komatsu et al. 2 in 1968. The overall success rate of limb replantation surgery is around 83.2%. 3 The mechanism of injury plays a role in the outcome; guillotine amputations-for example-carry a better prognosis than crush amputations. 4 We present a case report of a 36-year-old male patient who presented with a total avulsion of the right hand with multiple fracture levels at the level of trans-carpal, distal radius extra-articulation fracture, and total avulsion of the hand. The patient was managed by a multidisciplinary team who were able to reattach his hand successfully with good functional outcome. The microvascular repairs took 1.5 hours. The vessels were examined under microscopy (10×) to role out intimal injury and access length of segment need to debridement, which was 1.5 mm both ulnar and radial arteries and veins. This involved anastomosis by using Prolene 8.0. Dextran, 3,500 units, was administered intravenously to check the integrity of the anastomosis. After that, the median and ulnar nerves were repaired using Prolene 8.0. A fasciotomy of the forearm flexor compartment was performed to avoid compartment syndrome. Finally, the skin was closed with Vicryl Rapid 3.0 and staples. Bactigras and dressing were applied, and a back slab was cast to immobilize the limb. Secondary closure of skin by split-thickness skin graft was done 10 days later.

Disclosure
Following the surgery, the patient was transferred to the intensive care unit for observation. The patient was kept on heparin, 8000 units/h postoperatively for 7 days. No systemic or major wound complications developed, and the patient was shifted to the surgical ward after 3 days. The patient stayed in the ward for 1 month; he was kept well hydrated in a warm room 80˚F. Pain was well controlled by intravenous 5 mg morphine twice per day and 8 mg IV Lornoxicam twice daily for the first 3 days, then shift it to oral Acetaminophen 500 mg every 8 hours with Lornoxicam 8 mg IV twice daily for 6 days.
He was managed with daily regular loose dressing. Skin temperature, venous congestion and capillary refill, and pulse oximetry were closely monitored. Physiotherapy was consulted to arrange for rehabilitation sessions. The patient was discharged after 42 days with instructions to stop smoking and follow-up at the clinic with x-rays every 2 weeks to monitor bone healing. The K-wires were removed 2 months later (Fig. 4). One year after the operation, the range of motion active and passive at the wrist was acceptably preserved 45˚ on flexion, 35˚ on extension and 30˚ radioulnar deviation arc. Total active motion was

Sulaiman et al. • Hand Replantation in a Case of Total Avulsion
possible for the fingers on flexion and extension, and at the metacarpophalangeal, proximal interphalangeal, distal interphalangeal joints. Grip strength was 5 kg. Sensation was fairly recovered, present along the ulnar nerve distribution, but not in the median nerve or radial nerve distributions. The patient is now able to perform activities of daily living, engage in moderate physical activities.

DISCUSSION
Once limb-threatening amputation injuries are identified, appropriate interventions must be performed swiftly to optimize functional outcomes. The most important factors that play a role in outcomes are age, the presence of multiple levels of injury, the mechanism of injury, and the ischemia time. 5 This was a challenging case because the patient presented with multiple levels of injury of trans-carpal, distal radius extra-articulation fracture, and total avulsion of the hand, a crushing mechanism of injury, and a borderline optimal ischemia time, all of which carry a poor prognosis.
Previous studies have shown that in young patients, replantation success was highest with guillotine amputations (94%) and lowest with avulsion injuries (74%). 6 The outcomes were worst when the amputation was at or above the level of the elbow, and when associated with avulsion. 7 One of the strongest indications for replantation surgery in the upper extremity is hand amputation at the level of the wrist. 8 This is the reason our team worked hard to salvage the limb despite the suboptimal presentation.
In 2005, the American College of Surgeons Committee on Trauma concluded that vascular injuries should be treated within 6 hours of injury to maximize the success of limb salvage. Contraindications for surgery are a warm ischemia time of 6 hours and a cold ischemia time of 12 hours. When it comes to the hand, attempting replantation even with a poor prognosis due to prolonged isch-emia time is warranted. A study of 6 patients with a cold ischemia time of < 7 hours showed that they achieved successful replantation; the cases included in the study share a similar ischemia time with our case. 9 The management plan should be tailored to each case, and careful inspection of possible intimal injury of the vessels under proper magnification is crucial to prevent unnecessary debridement of vessels or vein grafts. 10 Our case was unique because rather than opting for the common management of using a long vein graft, we carefully inspected for intimal injury and minimal debridement and direct vessel repair was performed.

CONCLUSIONS
Hand amputation with avulsion injury is one of the challenging presentations in plastic and reconstructive surgery, both from a technical and a recovery standpoint. A coordinated multidisciplinary team approach is key for a successful replantation. Proper postsurgical care and rehabilitation are crucial for an optimal outcome.