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Human papillomavirus and gene mutations in head and neck squamous carcinomas

Background:  Human papillomavirus (HPV) infection is implicated as an aetiological factor in head and neck squamous carcinomas (HNSCC), especially in the tonsils of the oropharyngeal region. This study investigates the frequency of HPV infection, p16 and p53 tumour profile and mutations in epidermal growth factor receptor (EGFR), Kirsten RNA Associated Rat Sarcoma 2 Virus (KRAS) and B‐Raf proto‐oncogene serine/threonine protein kinase (BRAF) genes in tonsillar and non‐tonsillar HNSCCs and correlates with clinical outcome and histopathological parameters in previously unstudied cohort of patients.