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CYCLOPHOSPHAMIDE-INDUCED TOLERANCE TO EQUINE γ-GLOBULIN AND TO EQUINE ANTIMOUSE THYMOCYTE GLOBULIN IN ADULT MICE: II. Resulting Prolongation of Cardiac Allografts in ATG-Treated Animals

SUMMARY Cyclophosphamide (CY)-induced tolerance to equine γ-globulin (EqGG) prior to initiation of antithymocyte globulin (ATG) treatment in cardiac allografted adult mice was found to result in a striking increase in cardiac allograft survival. Even though chronic ATG administration led to a gradual decrease in the circulatory half-life of ATG, cardiac allografts remained viable.