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Predictive value of estrogen and progesterone receptors in endometrial hyperplasia and cancer

With great interest, we read the article by Raffone et al. published in AOGS 1 . In this systematic review and meta-analysis, the predictive value of estrogen receptor (ER) and progesterone receptor (PR) expression was evaluated for the response to conservative treatment in endometrial hyperplasia and endometrial cancer. Interestingly, the authors found that PR expression was predictive for response to progestin therapy in women treated with levonorgestrel-intra uterine device, but not in women treated with oral progestins.