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Angiotensin receptor type 1 antagonists protect against neuronal injury induced by oxygen–glucose depletion

BACKGROUND AND PURPOSE Several clinical trials and in vivo animal experiments have suggested that blockade of angiotensin receptor type 1 (AT1) improves ischaemic outcomes. However, the mechanism(s) underlying these effects has not been elucidated. Here, we have investigated the protective effects of pretreatment with AT1 receptor antagonists, losartan or telmisartan, against ischaemic insult to neurons in vitro.