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A Novel Synthesis of 5(E)-Isomer-Free Carboprost Methyl Ester

A macrocyclic lactone strategy to synthesis of 5(E)-isomer-free carboprost methyl ester had been developed firstly. The macrocyclic lactone was prepared from modified Corey lactone, which was free of 5(E)-isomer. The key intermediate could be applied to preparation of carboprost methyl ester, even to synthesis of other PGs as scaffold effectively.