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[Studies of citrate metabolism in urolithiasis. 2--Influences of citrate compound administration on sequential excretion of urinary citrate and other substances related to stone formation in healthy controls].

In five healthy men, the effect of two doses (3g/day and 4g/day) of orally ingested citrate compound, on urine volume, urinary pH, the excretion of citrate, calcium, magnesium, oxalate and creatinine were studied and compared with the corresponding values in a pre-loading day. Collections of every two hour urine (6 hours in night) were carried out to evaluate the influences of these administrations on circadian rhythms of them on consecutive three days. Following administrations of citrate compound, the urinary excretion of cirtate increased, and the rise of it was directly proportional to the dose. A rise in urinary pH was observed in the evening or early night. Although the urinary calcium decreased silightly, there were no changes in other substances, In addition, an ion activity product index of calcium oxalate was calculated using the formula which was described by Ahlstrand and associates (1984). The highest level of supersaturation of calcium oxalate was recorded after the ingestion of dinner on pre-treatment day. However, the level was reduced to an almost metastable range by administrations of citrate compound. In conclusion, the administration on citrate compound increased the urinary citrate, and decrteased the saturation level of calcium oxalate. It was thus suggested that the citrate therapy was effective in preventing new calcium stone formation, especially, calcium oxalate stones.