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Inhibition of prostaglandin-mediated ocular inflammatory responses by 4-biphenylacetic acid.

4-Biphenylacetic acid (BPAA),a prostaglandin-synthesis inhibitor, was tested for its effects on prostaglandin-related, laboratory models of ocular inflammation. Topically applied, BPAA inhibited arachidonic acid, but not prostaglandin E-induced increases in rabbit intraocular pressure (IOP). BPAA inhibited the IOP response to alkali burn and altered IOP changes following paracentesis. In vitro, BPAA inhibited prostaglandin production from arachidonic acid in cell-free preparations of rabbit uvea. It is suggested that BPAA may be useful for the therapy of ocular inflammatory disease.