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Evidence Summary: Super-oxidised solutions for chronic wounds

Super-oxidised solutions are a low cost topical antiseptic option for chronic wounds. Antibacterial, antimicrobial and anti-fungal properties of SOSs have been established in laboratory research1-7 (Level 5). Level 1 evidence from a systematic review8 and a randomised controlled trial (RCT)9 showed SOS was as effective as povidone iodine in reduction microbial bioburden. Level 1 evidence from a systematic review8 and four RCTs9-12 showed SOS was superior to both povidone iodine8,9,12 and saline9-11 for promoting healing, established using different outcome measures (e.g. percent of wounds healed,9 mean reduction in wound surface area,12 rate of healing9 and increase in granulation tissue).10 This evidence, together with additional Level 213 and Level 414-16 evidence, supported a Grade B recommendation (a weak recommendation)17.