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Early- and long-term outcomes after surgery for acute type a aortic dissection in patients aged 45 years and younger.

BACKGROUND
Acute type A aortic dissection (AAAD) is rare in young people. The early- and long-term outcomes after surgery for AAAD in patients aged ≤ 45 years was investigated.


METHODS AND RESULTS
Subjects were 355 patients who had undergone emergency surgery for AAAD. The patients were grouped as those aged ≤ 45 years (n=30; mean age, 38.3 years; younger group) and those aged > 45 years (n = 325; mean age, 65.3 years; older group). Clinical and prognostic variables were compared between the groups. Male sex, Marfan syndrome, and severe aortic regurgitation were more prevalent in the younger group. In-hospital mortality (16.7% vs. 8.6%, P = 0.15) and postoperative patency of the distal aorta (90.8% vs. 59.1%, P < 0.01) were more frequent in the younger group. The leading causes of late death were aortic rupture in the younger group (75.0%) and malignancy in the older group (27.5%). Although actuarial survival at 10 years was similar (64.5% vs. 62.5%), freedom from aortic reoperation at 10 years was decreased in the younger group (49.4% vs. 85.0%, P = 0.012). A distal aorta > 45 mm (P<0.001), Marfan syndrome (P < 0.01), and age ≤ 45 years (P = 0.045) were shown to be independent risk factors for reoperation.


CONCLUSIONS
Early- and long-term surgical outcomes are not better for patients ≤ 45 years, and the risk for reoperation is high in this group. Careful follow up is important in young patients with AAAD.