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Maternal Rhabdomyolysis and Twin Fetal Death Associated With Gestational Diabetes Insipidus

BACKGROUND: Gestational diabetes insipidus is a rare, transient complication of pregnancy typically characterized by polyuria and polydipsia that may lead to mild electrolyte abnormalities. More severe sequelae of gestational diabetes insipidus are uncommon. CASE: We present a case of a 25-year-old woman at 23 weeks of gestation in a dichorionic–diamniotic twin pregnancy who developed severe symptomatic gestational diabetes insipidus complicated by rhabdomyolysis and death of both fetuses. CONCLUSION: Maternal rhabdomyolysis caused by gestational diabetes insipidus is extremely rare. Early recognition and treatment of gestational diabetes insipidus is necessary to prevent maternal and fetal morbidity and mortality.