{'fraction_non_alphanumeric': 0.03820816864295125, 'fraction_numerical': 0.021080368906455864, 'mean_word_length': 5.2, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 1, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
FOOD MANIPULATION AND MINIMAL CHANGE NEPHROTIC SYNDROME (MCNS)

It has been proposed that MC NS is due to a variety of causes including hypersensitivity to inhalants, drugs, insects' sting, and/or foods. To test the latter, a study was undertaken in patients with MC NS (defined clinically and/or by biopsy) resistant to or dependent on corticosteroids or with frequent relapses (as defined by ISKDC). A response to dietary manipulation (improvement or worsening) was defined as the presence of acute and marked changes in 24 hr proteinuria (within 5 days, lasting>48 hr, increased≥4 fold or decreased to≤1/4). Most patients had simultaneous changes in weight, edema, urine output and serum albumin. Prior to the study period, all medications were discontinued; subsequently, no corticosteroids or immunesuppressors were administered until discharge from the protocol. 24 patients (age range 2-13 years) were studied over a 5 year period (1974-1979). 12 patients (50%) completed the study and had a response most likely as the result of dietary manipulation. 8 patients had no significant changes and 4 had incomplete studies. In conclusion: (1) observed changes probably were not due to spontaneous remission or relapse; (2) some patients did improve with dietary manipulation and no medications; (3) results obtained suggest need for further study to identify MC NS patients who would improve with dietary manipulation; (4) further study also is required to attempt quantitation of changes and objective conclusions.