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Ropinirole in Bipolar Disorder: Rate of Manic Switching and Change in Disease Severity

PURPOSE
To determine the effects of ropinirole on manic switching and disease severity in bipolar disorder.


DESIGN AND METHODS
A cross-sectional survey was conducted in 23 bipolar depressed patients using ropinirole combination therapy (Young Mania Rating Scale [YMRS], Bipolar Inventory of Symptoms Scale [BISS]). Retrospective Clinical Global Impression of Change (CGI-C) and CGI-S (Severity) were captured via chart review.


FINDINGS
One patient (4.3%) experienced induction of mania (YMRS). All patients responded or partially responded to ropinirole (CGIs). YMRS and BISS mania scores were correlated.


PRACTICE IMPLICATIONS
Ropinirole has a low rate of manic switching and significantly reduces bipolar depression severity.