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Nucleotide inhibition of post-orotate pyrimidine synthesis pathway enzymes of bovine mammary tissue.

Abstract Effects of various nucleotides are evaluated on enzymes of the post-orotate portion of the pyrimidine synthesis pathway from lactating bovine mammary tissue. Orotate phosphoribosyltransferase shows minimal activation by most nucleotides tested, but orotidine-5′-phosphate decarboxylase is highly inhibited by several nucleotides with xanthosine, cytidine, and uridine 5′-phosphates being the most effective. It is possible that product inhibition by uridine Diphosphate of orotidine 5′-phosphate decarboxylase is an important factor in the accumulation of orotate in bovine milk.