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Stimulation of Insulin Release in Vitro by Non-metabolized Amino Acid Analogues 1

Summary Two nonmetabolized amino acid analogues, α-aminoisobutyric acid (AIB) and 2-aminobicyclo |2,2,1| heptane-2-carboxylic acid (BCH) stimulated immunoreactive insulin (IRI) release from cultured fetal rat pancreas incubated in vitro. AIB was effective in the presence of either caffeine or glucose; whereas BCH was only active in the presence of the methylxanthine. AIB-induced IRI release together with glucose was inhibited by oligomycin or incubation at a low temperature. The uptake of 3H-AIB was demonstrated in this preparation. With changing experimental conditions, IRI release induced by AIB paralleled changes in AIB uptake (i.e., its active transport). The results suggest the existence of a relationship between the two phenomena.