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Prospective Assessment of Diagnostic Tests for Pediatric Penicillin Allergy: From Clinical History to Challenge Tests

MD Ibanez, P Rodriguez Del Rio, EM Lasa; Penicillin Allergy in Children (APENIN) Task Force; Pediatric Allergy Committee, Spanish Society of Allergy and Clinical Immunology (SEAIC). Ann Allergy Asthma Immunol. 2018;121(2):235–244.e3

To determine the efficacy of available diagnostic tools in penicillin allergy relative to the results of drug provocation tests (DPTs).

The population included 732 children ≤14 years of age presenting to participating allergy departments who reported an adverse drug reaction with benzylpenicillin (penicillin G), phenoxymethyl penicillin (penicillin V), amoxicillin-clavulanic acid, or cloxacillin. Patients with a history of severe skin conditions during the index reaction (IR), presence of skin disease not allowing skin testing, and/or any condition for which epinephrine use was contraindicated were excluded.

This was a multicenter study (38 allergists from 23 centers) across Spanish allergy departments (from the Spanish Society of Allergy …