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Profiles of PD-1 expression on CD8~+T cells in human immunodeficiency virus-1 infected individuals

Objective To investigate the expression level and clinical significance of PD-1 on CD8+T cells in HIV-1 infected individuals with different disease status.Methods Seventy-two HIV-1 infected individuals and twenty-nine healthy controls were enrolled in this study.The expression level of PD-1 on CD8+T cells were measured by flow cytometry assay.Correlations between PD-1 expression level and CD4 counts and plasma viral loads were analyzed.Results The expression level of PD-1 on CD8+T lymphocytes in HIV-1 infected individuals was significantly higher than that of healthy controls(30.395% vs 18.450%,P=0.001).The PD-1 expression level in HIV-1 infection correlated negatively with CD4+T cell counts(r=-0.401,P0.001)while positively with viral loads(r=0.247,P=0.0368).Upregulation of PD-1 in individuals with CD4 count below 200 cells/μl was significantly higher than that of subjects with CD4 count above 500 cells/μ(l P=0.002).Two remarkable iinfection peaks of PD-1 expression in primary infectionrs and AIDS patients were observed,but no significant difference was observed between long-term nonprogressors and healthy controls.Conclusions The expression level of PD-1 on CD8+T cells in HIV-1 infected individuals is up-regulateed and this expression level is correlated with disease progress.