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Investigation of polymorphisms in schizophrenia relevant genes

KEREN LEVIEL: Investigation of Polymorphisms in Schizophrenia Relevant Genes (Under the direction of Patrick F. Sullivan) Schizophrenia is a severe, debilitating, and complex disease. It is characterized by delusions, hallucinations, disorganized speech, and grossly disorganized or catatonic behavior. As a complex disease, schizophrenia is thought to be caused by many genes. In addition the etiology is thought to be heterogeneous across the population of persons suffering from schizophrenia. In an attempt to dissect the heterogeneity of the disease, and investigate the role of candidate genes associated with schizophrenia, several studies were completed. The first was a case only association study of neurocognition and COMT, a candidate gene for schizophrenia. This is the largest study of its kind to date. The second study addresses the possibility of predisposition due to differential expression of candidate genes. In this study expression of another candidate gene PRODH was assessed. Together these studies aimed at investigating the polymorphisms of candidate genes for schizophrenia.