{'fraction_non_alphanumeric': 0.040070713022981735, 'fraction_numerical': 0.027106658809664112, 'mean_word_length': 5.0, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Analysis of Clinical Characteristics and Prognosis of Patients With Stages I-III Colon Cancer Based on Seer Data


 Objective: This study analyzes the clinical features and prognosis of stages Ⅰ-Ⅲ colon cancer, and constructs a nomogram to predict the prognosis of patients. Methods: We included data from patients with stages Ⅰ-Ⅲ colon cancer confirmed by pathology after surgical treatment in the United States SEER (Surveillance, Epidemiology, and End Results) database from 2010-2015. The included patients are randomly divided into training cohorts and validation cohorts (ratio 1:1).The independent related factors of the prognosis of colon cancer patients were used to construct the nomogram and the web-based probability calculator.Concordance index (C-index) and calibration curve are used to evaluate the accuracy of the model. Results: After univariate and multivariate analysis, it was indicated that age, marital status, tumor grade, t-stage and n-stage were independent factors affecting prognosis of patients with stages Ⅰ-Ⅲ colon cancer. We built a nomogram and the web-based probability calculator based on this, and its C-index was 0.781 (95% CI: 0.77414–0.78786), and were superior to that of AJCC TNM Stage (C-index: 0.734, 95%CI: 0.72616–0.74184). The consistency test showed that the nomogram can effectively predict the prognosis of patients. The validation cohort confirms the reliability of the model. Conclusion: Age, marital status, tumor grade, t-stage and n-stage are independent factors affecting the prognosis of patients with stages Ⅰ-Ⅲ colon cancer. The nomogram we constructed in this way can better predict the prognosis of patients with stages Ⅰ-Ⅲ colon cancer.