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In vitro and In vivo Anti‐hyperglycemia Effect of Novel Amadori Rearrangement Compound, Arginyl‐fructosyl‐galactose

Amino acid derivatives such as arginyl‐fructosyl‐galactose (AFL) are formed through Amadori rearrangement, the early step of Maillard reaction from arginine and lactose in daily foods. However, very limited information is available about the effect of AFL on various biological activities. This is the first report of the mode of action and effect of AFL on the type 2 diabetes management related inhibition of postprandial hyperglycemia in vitro and in animal model. The inhibitory activities against a‐glucosidase and porcine pancreatic a‐amylase were investigated in vitro and in vivo animal model. In in vitro study, AFL had a significant inhibition against rat intestinal a‐glucosidase but showed mild inhibitory activity on porcine pancreatic alpha‐amylase. In rat fed on starch or sucrose meals, AFL significantly reduced the postprandial blood glucose increment after starch or sucrose loading in a dose dependent manner. These results indicate that AFL has an anti‐diabetic effect by suppressing carbohydrate absorption from intestine, and thereby reducing the postprandial increase of blood glucose.