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AB0228 Evaluation of TP-E Interval and TP-E/QT Ratio as a Predictor of Cardiac Arrhythmias in Autoimmune Rheumatic Disease

Background Cardiac rhythm disorders in rheumetic diseases are common problems as it is known. Objectives In this study it was aimed at investigating whether Tp-e/QT ratio could be an indicator in depicting this risk, in autoimmune rheumatic disease (ARDs) which the ventricular arrythmia frequency increases. Methods We enrolled 201 patients with ARDs (48 with ankylosing spondylitis, 21with systemic lupus erythematosus, 64 with rheumatoid arthritis, and 54 healthy controls. Blood samples were taken from all patients for CBC, ESR, CRP, and Anti-SSA/Ro, and Anti-SSB/La. All standart 12-lead ECGs were obtained at rest. The measurements of QT and Tp-e intervals were done. The Tp-e/QT ratio was calculated by using these measurements. Results There were no statistically difference between the patients with ARDs and the control group in terms of age, gender, body mass index (BMI), systolic and diastolic blood pressure and heart rate. In patients with ARDs, Tp-e interval and Tp-e/QT ratio were found to be higher when compared to control groups. Moreover, when we analyzed subgroups, Tp-e interval and Tp-e/QT ratio were found to be higher than control group in AS and RA patients (Table). Additionally, there was a correlation between Tp-e interval and Tp-e/QT ratio and inflammatory activity. Conclusions Our results demonstrated a higher value of Tp-e interval and Tp-e/QT ratio in patients with ARDs. These electrocardiographic ventricular repolarization indexes were significantly correlated with level of CRP and ESR. Large-scale prospective controlled studies are needed in this area. References Lehtinen K. Mortality and causes of death in 398 patients admitted to hospital with ankylosing spondylitis. Ann Rheum Dis. 1993;52:174 –6. Mathieu S, Gossec L, Dougados M, Soubrier M. Cardiovascular profile in ankylosing spondylitis: a systematic review and meta-analysis. Arthritis Care Res. 2011;63:557–63. Yildirir A, Aksoyek S, Calguneri M, Aytemir K, Kabakci G, Ovunc K, et al. QT dispersion as a predictor of arrhythmic events in patients with ankylosing spondylitis. Rheumatology. 2000;39:875–9. Disclosure of Interest None declared