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Serum allotype loss due to a lymphoid tumor in chickens.


 A rapidly growing transplantable lymphoid tumor in chickens caused the disappearance of selected allotype antigens at the a and c loci, which are presumed to control IgA. Two possible explanations are 1) molecules carrying the allotypes bind to the neoplastic cells, thereby enhancing tumor growth, and 2) the tumor virus infiltrates specific stem cells preventing further differentiation.