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Intragranular solute migration in a test granulation dried by fluidization and vacuum tumbler drying

School of Pharmacy, City of Leicester Polytechnic, Leicester, U.K. Intragranular solute migration has been studied in large masses of about 1 cm in diameter (Ridgway & Rubenstein, 1971) but little work has been done using granules of a size used in practice. Test granulations were prepared by wet massing heavy kaolin B.P. (200 g) with 50 ml of sodium chloride solution (lO%w/w) equivalent to 26.0 mg of salt per g dry weight. Wet granules from a sieve mesh 2800 pm were dried in a laboratory fluid bed dryer or in an evacuated vessel rocked back and forth in a water bath at 50" to simulate vacuum tumbling drying (Goodhart, Draper & Ninger, 1970). The dry granules and dust from the bag filter were separated into fractions on sieves ranging from 2057 to 45 pm in aperture and the intragranular migration in the two larger sizes examined by prolonged sieving on a 250 pm mesh sieve and determining the salt content of the abraded powder at intervals (Fig. 1A and 1B). D. N. TRAVERS