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BIOFILM AND RELATED ANTIMICROBIAL
RESISTANCE

In recent decades, fungal pathogens have become a serious hazard to humanity due to their rising association with high rates of morbidity and mortality rate. Concerningly, limited availability and developing antimicrobial resistance to antimycotics available have increased the frequency of illness. The pathogen requires essential virulence traits, such as biofilm formation, in order to survive and flourish in the surrounding environment. Fungal biofilm is a complex architecture where cells breed, multiply and flourish in extracellular matrix (ECM). Fungal cells get adhered to biotic and abiotic surface and form biofilm which not only provide suitable microenvironment for their survival but also protect the cells from harsh environment insults. Considering the significant significance of biofilm, this review focus on the fundamental idea of biofilm, its composition and formation majorly of Aspergillus and Candida. Further it also elaborates the role of extracellular matrix in pathogenesis and ECM related antimicrobial resistance mechanisms.