{'fraction_non_alphanumeric': 0.03747072599531616, 'fraction_numerical': 0.00702576112412178, 'mean_word_length': 5.380597014925373, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Urinary α- and π-glutathione s-transferases for early detection of acute kidney injury following cardiopulmonary bypass

Abstract Context: Urinary α-GST and π-GST are renal tubular leakage markers. Objective: To evaluate the performance characteristics of these markers for the early detection of acute kidney injury (AKI). Materials and methods: Multicenter prospective cohort study of 252 adults undergoing cardiopulmonary bypass (CPB). Results: AKI developed in 72 patients. The 2 h post-CPB π-GST level modestly predicted the development of AKI, including higher stages of severity, whereas α-GST did not. Discussion: Small number of events and absence of subsequent post-operative biomarker measurements. Conclusions: Among adults undergoing CPB, urinary π-GST outperformed α-GST for predicting AKI, but neither marker displayed good discrimination.