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The Kidney in Gout and Hyperuricemia

This is a concise collection of articles from world-famous authors who have in common an interest in uric acid metabolism and a previous association with Dr Alexander B. Gutman. Consequently, the views represented may seem a little parochial, but the presentation of data is complete, and areas of controversy are acknowledged. An initial chapter chronicles some of the personal experiences and views of Dr John H. Talbott in the field of hyperuricemia. It is a well-written historical overview that places much of our current understanding in interesting perspective. Of note is Dr Talbott's sense that long-standing hyperuricemia has a toxic effect on the kidney, a viewpoint contested in later chapters. Dr Irwin M. Weiner has contributed a scholarly and comprehensive review of current information on the renal handling of urate, which is lucid and well organized. A chapter on renal function in gout by Dr Berger is of importance primarily