{'fraction_non_alphanumeric': 0.05027322404371585, 'fraction_numerical': 0.024043715846994537, 'mean_word_length': 5.083056478405315, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Systemic and Regional Hemodynamic Effects of the 5‐Hydroxytryptamine1A Receptor Agonists Flesinoxan and 8‐Hydroxy-2(Di-N-Propylamino)Tetralin in the Conscious Rat

The systemic and regional hemodynamic effects of the centrally acting 5-Hydroxytryptamine1A (5-HT1A) receptor agonist flesinoxan (0.5 and 2.5 mg kg1. intraarterially, i.a.) were investigated in conscious freely moving spontaneously hypertensive rats (SHR) and compared with those of 8-hydroxy-2(di-N-propylamino)-tetralin (8-OH-DPAT) (0.1 and 0.5 mg kg 1, i.a.). In one group of animals, cardiac output (CO) was measured with a precalibrated electromagnetic flow probe around the ascending aorta. In another group, regional vascular conductances were measured using radioactive microspheres. Flesinoxan and 8-OH-DPAT dose dependently decreased blood pressure (BP) (22 ± 5 and 13 ± 4%, respectively, at the highest dose) mainly resulting from an increase in total peripheral vascular conductance (TPC) (34 ± 12 and 16 ± 3%, respectively) since there was no effect on CO. Both drugs reduced heart rate (HR) (17 ± 4 and 20 ± 4% for flesinoxan and 8-OH-DPAT, respectively, at the highest dose). Flesinoxan and B-OH-DPAT showed a qualitatively similar pattern with regard to their effects on vascular conductances, causing increases in vascular conductances in the heart and skeletal muscles in contrast to results in a saline-treated group. Vascular conductances in the lungs were markedly increased by both tlesinoxan and 8-OH-DPAT, which may indicate that the conductance in the arteriovenous shunt vessels was enhanced. These results demonstrate that tlesinoxan and 5-OH-DPAT elicit a qualitatively similar systemic and regional hemodynamic profile in conscious SHR. Furthermore, the increase in TPC appears to be due mainly to vasodilatation in the skeletal muscles.