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Remote Ischemic Conditioning: Evolution of the Concept, Mechanisms, and Clinical Application

Abstract  Remote ischemic conditioning is a novel concept of protection against ischemia‐reperfusion injury. Brief controlled episodes of intermittent ischemia of the arm or leg may confer a powerful systemic protection against prolonged ischemia in a distant organ. This conditioning phenomenon is clinically applicable and can be performed before—preconditioning, during—perconditioning, or after—postconditioning prolonged distant organ ischemia. The remote ischemic conditioning may have an immense impact on clinical practice in the near future. (J Card Surg 2010;25:127‐134)