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Successful Treatment of a Primary Cardiac Leiomyosarcoma with Ifosfamide and Etoposide

Purpose: Primary cardiac leiomyosarcoma is a rare malignant tumor in childhood. Patients with unresectable or partially resected cardiac leiomyosarcoma typically have a poor prognosis. The role of chemotherapy in the treatment of these patients has not been well defined. Patient and Methods: A 6-week-old infant with an incompletely resected cardiac leiomyosarcoma was treated postoperatively with ifosfamide and etoposide. Results: The patient is disease-free and without apparent late effects 5 years following the completion of therapy. Conclusion: The combination of ifosfamide and etoposide warrants further evaluation in patients with leiomyosarcoma.