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Application of an assessment of inotropic changes in intact heart: responses to infusions of catecholamines and stimulation of nerves.

After a consideration of published work and an examination of isolated muscle preparations we concluded that we could not measure directly the inotropic effect but could use an index which would give a quantitative means of assessing relative quantitative effects (Furnival et al. 1970). Briefly, using the peak rate of change of pressure in the left ventricle (dP/dt (max)) as the index of the inotropic state we infused isoprenaline at increasing rates and measured the changes in dP/dt (max). Because isoprenaline is said to have a greater chronotropic than inotropic effect it was possible to use this drug to examine the relative sensitivity of dP/dt (max) as an index of the change in inotropic state. Fig 1 shows that in the