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Tissue‐Engineered Calcium Alginate Patches in the Repair of Chronic Chinchilla Tympanic Membrane Perforations

Objective: Chronic tympanic membrane perforations are a common problem in the United States. A high number of these cases results from placement of pressure equalization tubes. These perforations may initially be treated with paper patch techniques and although safe and well tolerated, the procedure demonstrates poor efficacy. The ideal treatment for small perforations should be rapid, minimally invasive, and efficacious. Calcium alginate‐based tissue engineered tympanic membrane patches represent an attractive option, but in vivo data are required.