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Practical Use of Adjuvant rhBMP-2 to Augment Bone Healing in Foot and Ankle Surgery

The use of adjuvant osteobiological agents has begun to revolutionize musculoskeletal surgery, by providing reliable, safe osteobiological augmentation, with robust bone healing in patients who in the past were considered to be nonoperative candidates. Among the current osteobiological adjuvant agents, recombinant bone morphogenetic protein-2 has emerged as the most reliable for patients with high-risk foot and ankle surgery. The basic science, practical clinical applications, and techniques of recombinant bone morphogenetic protein-2 are presented.