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Optical clearing of skin using flashlamp‐induced enhancement of epidermal permeability

Strong light scattering in skin prevents precise targeting of optical energy in therapeutic and diagnostic applic ations. Optical immersion based on matching refractive index of scattering centers with that of surrounding matter through introduction of an exogenous index‐matching agent can alleviate the problem. However, slow diffusion of the index‐matching agent through skin barrier makes practical implementation of this approach difficult. We propose a method of accelerating penetration of the index‐matching compounds by enhancing skin permeability through creating a lattice of micro‐zones (islets) of limited thermal damage in the stratum corneum (SC).