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PHOTODEGRADATION OF NIFEDIPINE UNDER in vivo‐RELATED CIRCUMSTANCES

In view of light‐induced side effects of the drug nifedipine (NIF), its photodegradation was studied under in Wvo‐related conditions. There proved to be no difference between UVA and daylight. In phosphate buffer, the nitroso derivative of NIF was the only photoproduct. In the presence of glutathione (GSH), in plasma and in blood, the nitroso derivative is a short‐lived intermediate, which proved to be very reactive. With GSH, both the photodegradation of NIF and the incubation of the nitroso derivative in the dark quantitatively produced a lactam. The implications of the photodegradation under in vivo‐related conditions for light‐induced side effects of NIF are discussed.