{'fraction_non_alphanumeric': 0.035515320334261836, 'fraction_numerical': 0.018802228412256268, 'mean_word_length': 4.889344262295082, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
[Effect of photodynamic therapy on interleukin in gingival crevicular fluid from patients receiving oral implantation].

PURPOSE
Photodynamic therapy (PDT) has been applied in treatment of peri-implantitis for its antimicrobial effects. The aim of the study was to evaluate the effects of a Denfotex PAD Light System's photodynamic therapy on prevention of peri-implantitis.


METHODS
Twenty patients with implants in molar area were treated with photoactivated disinfection right after completion of suprastructures. The irradiation time was 30 seconds for mesial, distal, buccal and lingual/palatal sites respectively at a power output of 100mW. Gingival crevicular fluid (GCF) samples from these patients were obtained before photodynamic treatment, 2 weeks and 3 months after treatment. GCF was collected using paper points, and enzyme-linked immunosorbent assay (ELISA) was performed to determine the cytokine (IL-1β, ΤΝF-α, IL-6 and ΙL-17) levels. The data were analyzed with SPSS 23.0 software package.


RESULTS
ELISA showed IL-1β and ΤΝF-α levels of all patients were decreased 2 weeks and 3 months after treatment. Reduction of IL-1β, ΤΝF-α, IL-6 and IL-17 from 2 weeks to 3 months and from baseline to 3 months all showed a significant difference (P＜0.05).


CONCLUSIONS
Denfotex PAD light system is effective in reducing peri-implant inflammatory mediators and can work as an effective treatment to prevent peri-implantitis.