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[Indicators of risk of reagin allergy. IV. HLA markers].

The concept of a genetic score was described in a previous publication by our group. It indicated that patient groups separated by this score may help to identify a possible genetic factor of allergic risk. In the present study, 1,800 children under the age of 13 were reviewed. Groups were classified by genetic score. The determination of loci A and B of HLA system was performed in 93 allergic children and revealed a highly significant correlation between HLA B12 and genetic score. On the other hand, the frequency of HLA A2 decreased with age. This fact can be interpreted as a prognostic indicator of allergic disease in children.