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Reduced‐intensity conditioning–based hematopoietic cell transplantation for dyskeratosis congenita: Single‐center experience and literature review

Bone marrow failure in dyskeratosis congenita (DKC) is progressive, and allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment. However, outcomes after HCT are suboptimal because of mucosal, vascular, pulmonary, and hepatic fragility, which can be exacerbated by chemotherapy conditioning and graft‐versus‐host disease (GVHD). These toxicities can be mitigated by reducing the intensity of the conditioning regimen.