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Recent Advances in Solid Phase Organic Synthesis (SPOS)

Owing to its automatability, solid phase organic synthesis (SPOS) continues to evolve as a means to create and modify compound libraries via combinatorial chemistry. SPOS is a technology adapted from bio-chemistry and peptide synthesis pioneered by R. B. Merrifield, which later earned him a Nobel Prize in Chemistry in 1984. The solid-phase synthesis carries many advantages over classical solution-phase synthetic methods which may include purification of products by simple filtration of the polymer matrix, easy handling, low moisture susceptibility, minimum side reaction, polymerization-free due to site-isolation of polymer beads and recyclability of the polymer matrix for repeated use; thereby adding the ‘green’ credentials of the whole processes. Consequently, polymer-bound reagents have drawn huge attention from industry and academia for their easy handling, separation, and reusability. In addition, as polymeric reagents/catalyst can be recycled and reused they can be used in an excess amount to drive the reaction faster.