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The strategy of editing and modification of the genomes of bacterial viruses

In recent decades, a major problem for health systems around the world is the wide spread of bacterial pathogens that are resistant to various antimicrobial agents. A possible approach to solving this problem is the use of bacteriophages, viruses that specifically infect bacterial cells, as well as enzymes and proteins encoded in their genomes. The development of genomic editing technologies, including those based on CRISPR-Cas editing, makes it possible to create genetically engineered or recombinant phage particles with desired properties that are important for further practical application. In this review, we consider issues related to the characterization of bacteriophages as biological objects and as promising candidates for controlling the spread of antibioticresistant bacterial strains. We discuss modern approaches and strategies for modifying the phage genomes using various methods of genetic engineering and molecular biology to solve a variety of practical and research problems. Keywords: bacteriophages, phage genome editing, CRISPR-Cas system