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Comprehensive comparison of Local Effect Model IV predictions with the Particle Irradiation Data Ensemble.

PURPOSE
The increased relative biological effectiveness (RBE) of ions is one of the key benefits of ion radiotherapy compared to conventional radiotherapy with photons. To account for the increased RBE of ions during the process of ion radiotherapy treatment planning, a robust model for RBE predictions is indispensable. Currently, at several ion therapy centers the Local Effect Model I (LEM I) is applied to predict the RBE, which varies with biological and physical impacting factors. After the introduction of LEM I, several model improvements were implemented, leading to the current version, LEM IV, which is systematically tested in this study.


METHODS
As a comprehensive RBE model should give consistent results for a large variety of ion species and energies, the Particle Irradiation Data Ensemble (PIDE) is used to systematically validate the LEM IV. The database covers over 1100 photon and ion survival experiments in form of their linear-quadratic parameters for a wide range of ion types and energies. This makes the database an optimal tool to challenge the systematic dependencies of the RBE model. After appropriate filtering of the database, 571 experiments were identified and used as test data.


RESULTS
The study confirms that the LEM IV reflects the RBE systematics observed in measurements well. It is able to reproduce the dependence of RBE on the linear energy transfer (LET) as well as on the αγ /βγ ratio for several ion species in a wide energy range. Additionally, the systematic quantitative analysis revealed precision capabilities and limits of the model. At lower LET values the LEM IV tends to underestimate the RBE with an increasing underestimation with increasing atomic number of the ion. At higher LET values, the LEM IV overestimates the RBE for protons or helium ions whereas the predictions for heavier ions match experimental data well.


CONCLUSIONS
The LEM IV is able to predict general RBE characteristics for several ion species in a broad energy range. The accuracy of the predictions is reasonable considering the small number of input parameters needed by the model. The detailed quantification of possible systematic deviations, however, enables to identify not only strengths but also limitations of the model. The gained knowledge can be used to develop model adjustments to further improve the model accuracy, which is on the way. This article is protected by copyright. All rights reserved.