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Therapeutic Effect of Chemically Synthesized Silver Nanoparticles on Aphthous Stomatitis in Some Iraqi Patients

Silver nanoparticles (AgNPs) were synthesized by a chemical reduction method. The particles were 
synthesized using silver nitrate solution with sodium borohydride as the reducer. The resulting colloidal 
AgNPs were characterized by UV-Visible spectroscopy, and FTIR. Aphthous stomatitis is a common and 
recurrent painful disease of the oral mucous membrane, classified in to three different aphthous types: minor, 
major and herpetiform. It may appear due to a variety of causes including: stress, food, hypersensitivities, 
infection, trauma, drug allergy, nutrition deficiencies (Iron, zinc & vitamin B12) or it could be a symptom of 
serious disease such as carcinoma. In this study, (75) young Iraqi patients aged (18-24) years divided in to 
two groups according to their gender (25 male and 50 female) all of them are suffering from major Aphthous 
ulcers in the mouth. The solution of (10 µg/ml) concentration of silver nanoparticles showed a uniform 
cycle inhibition around the ulcer growth zone while, increasing of (AgNPs) solution to (20 µg/ml) showed 
a highly and significant inhibitory effect against isolates from Aphthous stomatitis during the first 24 hours 
only in both male and female groups. Further studies is needed to investigate the inhibitory mechanism of 
(AgNPs) against Aphthous stomatitis.