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Management of Sickle Cell Disease in Primary Care

S ickle cell disease (SCD) is a hereditary hemoglobinopathy that is manifested by chronic hemolytic anemia and intermittent occlusion of small blood vessels leading to chronic tissue ischemia, chronic organ damage, and dysfunction. In the United States, approximately 2000 infants affected by this disorder are born each year.' Over the past few decades, there has been a significant decrease in the morbidity and improvement in the life expectancy of patients with SCD due to early detection as well