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Altering Lentiviral Tropism: Design and Implications of a Targeted Drug-Delivery System

A significant challenge in modern clinical medicine is that despite the existence of genetic therapies, lack of techniques to deliver them to the body remains a major roadblock. Viral vectors, benign vehicles for therapeutic delivery produced by removing the reproductive and virulence capacities of wild-type viruses, address this obstacle [1]. Unfortunately, if there is no naturally-occurring virus which infects a particular tissue it is nearly impossible to systematically deliver a therapy to that site. Moreover, the tropism of naturally-occurring viruses is often too broad or too narrow for delivery to both be effective and avoid off-target effects [2].