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The Measurement of Opening Angle and Orifice Area of a Bileaflet Mechanical Valve Using Multidetector Computed Tomography

Background and Objectives The aim of this study was to assess mechanical valve function using 64-slice multidetector computed tomography (MDCT). Subjects and Methods In 20 patients (mean age, 50±12 years; male-to-female ratio, 10:10), 30 St. Jude bileaflet mechanical valves (15 aortic and 15 mitral valves) were evaluated using MDCT. We selected images vertical and parallel to the mechanical valve. The valve orifice area (OA) and valve length were determined by manual tracing and the opening and closing angles were measured using a protractor. The OA and length of the mechanical valves were compared with the manufacturer's values. Results The geometric orifice areas (GOAs) based on the manufacturer's values and the OAs determined by MDCT were 3.4±0.2 cm2 and 3.4±0.3 cm2 for the mitral valves and 2.1±0.3 cm2 and 2.1±0.4 cm2 for the aortic valves, respectively. The correlation coefficients between the OA measures were 0.433 for the mitral valves and 0.874 for the aortic valves (both p<0.001). The lengths based on the manufacturer's values and determined by MDCT were 29.3±1.99 mm and 29.6±1.65 mm for the mitral valves and 21.5±2.1 mm and 20.7±2.3 mm for the aortic valves, respectively. The correlation coefficients between the measures were 0.651 for the mitral valve and 0.846 for the aortic valve (both p<0.001). The opening and closing angles determined by MDCT were 10.9±0.6° and 131.1±3.2° for the mitral valves and 11.1±0.9° and 120.6±1.7° for the aortic valves, respectively. Conclusion MDCT is an accurate modality with which to assess the function and morphology of bileaflet mechanical valves.


Introduction
Traditionally, after mechanical valve replacement, transthoracic Doppler echocardiography (TTE) has been considered the diagnostic standard method for assessing and establishing mechanical valve (MV) function. 1) However, an assessment of MV function by TTE has limitations, such as excessive metallic artifacts and a poor echo window in obese patients. Further, TTE is of limited value for patients with chronic obstructive pulmonary disease and for the evaluation of a MV in the aortic position. 2) Even though transesophageal Doppler echo-cardiography (TEE) can provide better image quality, 3) TEE is a semi-invasive method and can show metallic artifacts. It is difficult to obtain a perpendicular image of the MV with a fluoroscopic examination 4) and an accurate measurement of the opening angle is difficult to obtain. [4][5][6][7][8] Recently, the use of 64-slice multidetector computed tomography (MDCT) has been shown to be valuable for the measurement of coronary artery stenoses, [9][10][11][12] determination of coronary calcium scores, 13) measurement of left ventricular ejection fractions, 14) follow-up of percutaneous coronary intervention, 15) 16) and follow-up of coronary artery bypass grafts. [17][18][19][20] The aim of this study was to assess MV function using 64slice MDCT.

Subjects
This prospective study was performed on 20 patients Multidetector computed tomography protocol and image reconstruction Computed tomographic studies were performed on a 64-slice MDCT (Lightspeed VCT; GE Healthcare, Milwaukee, WI, USA). The heart rate during CT acquisition ranged from 50-97 bpm (mean, 69 bpm). The patients did not receive additional premedications, such as β-blockers, for control of their heart rate.
The MDCT protocol was as follows: slice collimation (64×0.625 mm), gantry rotation time (350 ms), table feed (6 mm/s), tube voltage (120 kVp), and tube current (600 mAs). Eighty mL of contrast agent (Iopromide, Ultravist 300; Schering, Berlin, Germany) was injected intravenously at 5 mL/s for 16 seconds. Fifty mL of saline solution chaser at 5 mL/s for 10 seconds was also injected. All examinations were performed using retro-spective electrocardiography (ECG)-gating. Image data was reconstructed using the cardiac image reconstruction algorithm provided with the scanner. Images were reconstructed at consecutive 10% increments of the relative risk (R-R) interval, yielding 10 phases of information. All post-processing was performed on a GE AW Workstation (Advantage Windows Workstation 4.3), using the Card IQ function software (GE Healthcare). Image data was reconstructed in the vertical and parallel images of the MV. The opening and closing phases of the MV were selected visually for image analysis. Window settings were adjusted to properly visualize the valve with less beam-hardening artifact.

Image analysis
The images were analyzed using an Image-Pro Plus Image analyzer (

Statistical analysis
Data are expressed as the mean and standard deviation (SD), and statistical analysis was done using Statistical Package for Social Science (SPSS) 13.0 (SPSS Inc., Chicago, IL, USA). Linear regression analysis and the limits of agreement according to Bland and Altman were determined to compare geometric parameters of the bileaflet mitral MV between the manufacturer's va- lues and the MDCT measurements. Student's t-test was used to compare the manufacturer's values with those determined by MDCT. P<0.05 was considered statistically significant.

Results
The mean age of the patients (10 females and 10 males) in the study was 50±12 years. Ten patients received replacement of mitral or aortic bileaflet MVs. Five patients received double MV replacements. The mean follow-up duration after undergoing bileaflet MV replacement was 99±74 months.
The mean size of the bileaflet aortic MVs was 21.
The manufacturer's values and the MDCT-determined valve lengths were 29.3±1.99 mm and 28.6±1.65 mm for the mitral valves and 21.5±2.1 mm and 20.7±2.3 mm for the aortic valves, respectively. The correlation coefficients between the valve lengths based on the manufacturer's values compared with the MDCT measurements were 0.651 for the mitral valves and 0.846 for the aortic valves (p<0.001) (Fig. 5A).
The Bland-Altman analysis of bias revealed that there was no significant bias between the lengths based on the manufacturer's values and the MDCT measurements for the mitral valves (observed bias, 0.791; 95% confidence interval, 0.639-0.934) (Fig. 5B) and for the aortic valves (observed bias, 1008; 95% confidence interval, 0.702-1.313; p<0.001) (Fig. 5C). The opening and closing angles

Discussion
The use of MDCT has facilitated the non-invasive detection of coronary artery calcifications, 13) visualization of the lumens and walls of the coronary arteries, and the ability to obtain information on the presence and severity of coronary artery disease (CAD). [9][10][11][12] Over the last several years, a dramatic improvement in MDCT technology has allowed for an assessment of valve morphology and calcification in patients with mitral and aortic stenoses. 21)22) MDCT has led to advances in the assessment of cardiovascular anatomy and function and has created new clinical applications in cardiovascular imaging. 23) These applications include follow-up of percutaneous coronary intervention, 15)16) follow-up of coronary artery bypass grafts, [17][18][19][20] assessment of the anatomy of the pulmonary vein of patients with atrial fibrillation, [24][25][26][27][28] and determination of the coronary sinus of patients planning cardiac resynchronization therapy. Some studies have reported that the MDCT is a sensitive and objective method for accessing the morphology and calcification of native aortic and mitral valves. 21)22) TTE is recommended in a step-by-step approach in the evaluation of patients with suspected prosthetic valve dysfunction. If a high gradient is detected, additional tests may be needed, including TEE and a fluoroscopic examination. However, TTE has some limitations (i.e., excessive metallic artifacts), and TEE and fluoroscopic examination do not always provide for a definitive diagnosis.
For both the GOAs and valve lengths, the values determined by 64-slice MDCT were as accurate as the manufacturer's values based on correlation coefficients, not only for the mitral valves (GOA, 0.433; length, 0.651; p<0.001), but also for the aortic valves (GOA, 0.874; length, 0.846; p<0.001). Therefore, we consider 64-slice MDCT to be an accurate modality for the morphologic and functional assessment of bileaflet MVs.
It is well-known that 64-slice MDCT requires exposure to a higher radiation dose {approximately 10 milli-Sieverts (mSv)} than the mean effective dose of diagnostic coronary artery angiography (usually between 3.0 and 6.0 mSv). To evaluate and generalize the function and morphology of bileaflet MVs using MDCT, patient selection should made with care.

Limitations
The first limitation of this study was it was only performed on patients who received SJM valves, a kind of bileaflet MV and the majority of patients had normal left ventricular function. Our study did not include patients with Ball-in-cage type valves (e.g., the Starr-Edwards prostheses) or other bileaflet mechanical prostheses (e.g., the Carbomedics prostheses and bioprostheses).
Secondly, it may be questioned whether an assessment of the GOA or length by 64-slice MDCT is superior for hemodynamic conditions, such as significant regurgitation. Although panni, thrombi, and vegetations were not detected in this study, the opening and closing angles determined by 64-slice MDCT may also provide better information for a severe mismatching valve. This will require future study.

Conclusions
MDCT is a powerful and promising modality by which to assess the function and morphology of bileaflet MVs. If appropriate patient selection has been undertaken, such as for patients with a normal sinus rhythm, a poor echo window on TTE, refusal to undergo TEE, and patients in a clinically stable condition, the optimal use of this technology could prove essential for comprehensive evaluation of valve function.