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p53 Gene Expression and Perioperative Chemotherapy in Breast Cancer

Objective To investigate the relationship between p53 gene expression and the short time effect of perioperative chemotherapy in breast cancer patients.Methods 108 cases of breast cancer were studied the p53 gene expression was detected by immunohistochemical staining(S P method) and the shorttime effect of perioperative chemotherapy,clinical and pathological parameter were analyzed.Before operation,the patients accepted one cycle of CMF chemotherapy(cyclophosphamide,600 mg/m 2 i.v. d1 and d8;methotrexate,30 mg/m 2 i.v. d1 and d8;5 Fluorouracil,500 mg/m 2 i.v. d1 and d8).Results The shorttime effect of perioperative chemotherapy was in negative correlation to p53 gene expression.The pathological type and the levels of ER and PR were related to p53 gene expression,while the TNM stage,axillary lymphonode metastasis were not related to it.Conclusion This study indicates that the detection of p53 gene expression has important value to instruct breast cancer chemotherapy.