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Age‐related changes of leptin and leptin receptor variants in healthy elderly and long‐lived adults

Aging is usually associated with hyperleptinemia and leptin resistance, both increasing the risk of age‐related diseases. It was relevant to establish if healthily aging, non‐obese individuals develop changes in leptin, the soluble leptin receptor (OB‐Re), free leptin index (FLI), in methylation of the leptin receptor gene (LEPR) promoter, and in the expression of long (OB‐Rb) and short (OB‐Ra) leptin receptor isoforms.