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Dihydrotestosterone may contribute to the development of migraine headaches.

PURPOSE
To evaluate the possibility that dihydrotestosterone (DHT) may play a role in the etiology of some people's migraine headaches.


METHODS
Finasteride 5 mg daily was given to a young woman with chronic migraines.


RESULTS
The chronic migraine headaches almost completely disappeared shortly following therapy. However, symptoms returned shortly after stopping the finasteride due to dry eyes.


CONCLUSIONS
DHT may be an etiologic factor in causing migraines since finasteride suppresses DHT secretion. Alternatively, the benefit could be related to some other property of finasteride possibly by increasing testosterone which may compete with estrogen at the blood vessel level.