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Electron Microscopy Fixative Fails to Inactivate Rift Valley Fever Virus

Rift Valley fever (RVF) virus, a member of family Bunyaviridae, genus Phlebovirus, is a mosquito‐borne zoonotic pathogen endemic to Sub‐Saharan Africa and the Arabian Peninsula that causes severe epizootics in ruminants. RVF outbreaks in ruminants are associated with mass abortions and high mortality in younger animals. Human infections at all ages are associated with acute febrile illness that may progress to more severe disease including encephalitis and severe hepatitis leading to fatal hemorrhagic fever. RVF virus (RVFV) is classified as an overlap select agent by the Center for Disease Control and Prevention and the US Department of Agriculture. In the US, work with virulent RVFV strains must be conducted in BSL‐3+ and requires RVFV specific select agent clearance.