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Computer simulation of Wilson's disease and its treatment with D-penicillamine

Wilson's disease and its treatment with D-penicillamine was studied by computer simulation. For proper simulation of Wilson's disease it was necessary to consider a separate form of liver copper and for treatment a separate urinary excretion of a D-penicillamine copper. Both have been suggested, but not previously demonstrated. These simulations support the conclusion that the liver is not de-coppered by D-penicillamine neither in Wilson's disease patients nor in normal individuals. These findings are in accord with current research on the molecular biology of Wilson's disease and support conclusions that the D-penicillamine-copper complex may facilitate redistribution of copper to enable physiological and biochemical responses required to overcome the liver inflammatory disease associated with Wilson's disease.