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Holding protein pairs in place

Biomolecular Imaging
Superresolution fluorescence imaging can determine where protein interactions occur in cells. However, this method can suffer from false positives because the detection of protein proximity is a function of optical resolution. Clowsley et al. ensured that the detected signals come from a particular pair of interacting proteins by using the DNA-PAINT (point accumulation imaging in nanoscale topography) method. In this method, proteins bind to two different antibodies that in turn are bound to DNA constructs. DNA-imaging strands are active only if the two constructs are close enough to enable DNA dimerization. This was used to image cardiac proteins in isolated cardiomyocytes with nanoscale resolution.

J. Am. Chem. Soc. 10.1021/jacs.9b03418 (2020).