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[Changes in the parameters of hepatic function in biliary lithiasis].

Our study investigates liver involvement serum parameters in 71 subjects with cholelithiasis and choledocholithiasis, without primary liver diseases. As a control group 118 healthy subjects were studied. All patients have been examined for serum transaminases, alkaline phosphatase and gamma-glutamyl-transpeptidase, total bilirubin and for liver enlargement. The results point out the presence of increased alkaline phosphatase and gamma-glutamyl-transpeptidase levels in more than half examined patients, and in nearly half of those without hyperbilirubinemia. This fact confirms that the existence of biliary lithiasis itself (even if limited to gall-bladder, in absence of jaundice) may account for the occurrence of a subclinical cholestatic liver impairment, that should be carefully considered in long-term prognosis of these patients.