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Changes in expression of matrix metalloproteinases 12 and 19 in corneal epithelial cells after UV irradiation

Purpose Matrix metalloproteinases (MMPs) are zinc‐binding endopeptidases that degrade various components of extracellular matrix. MMP‐12 participates in macrophage migration and MMP‐19 is involved in regulation of angiogenesis. Based on our previous findings dealing with the coincidence of the concentration of proteolytic enzymes with the severity of corneal injury induced by UV irradiation, the aim of this study was to investigate the effects of UVA and UVB rays on expression of matrix metalloproteinases 12 and 19 in the corneal epithelium.