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Coupling cellular metabolism to neuronal signalling

Although it has long been appreciated that much of the brain's energy is devoted to neuronal signalling, it is unclear if and how these two processes are coupled. To explore this emerging area of neuroscience, The Journal of Physiology sponsored a symposium at The Physiological Society's annual meeting, Physiology 2014, in London to bring together five researchers (see Fig. 1) whose work is at the forefront of this rapidly developing field of study. This issue of The Journal of Physiology brings together six timely review articles from some of these speakers and other researchers whose work captures some of the ideas, discussions and debates that arose during the 2014 Symposium on ‘Coupling cellular metabolism to neuronal signalling’.