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A Study on Expression of Integrin αv m RNA in Esophageal Squamous Cell Carcinoma

Objective: The study aimed to detect the integrin αv(ITGA V) m RNA expression in Esophageal squamous cell carcinoma(ESCC), and to evaluate the correlation between integrin αv m RNA expression and clinicopathological factors. Methods:From 2012 to 2013, 72 cases of tissue samples of ESCC patients as the research object, and the 33 esophageal inflammation tissues as control. Real-time PCR assay was performed to detect the expression of ITGA V in all tissue samples. The RT-PCR results were analyzed and the correlation between ITGA V expression and clinicopathological factors was evaluated. Results: In ESCC patients' tissues, the expression level of ITGA V m RNA was significantly higher than those in the inflammation tissues(P0.05), and the expression level were significantly correlated with T, N and clinical stage(all P0.05). Conclusion: All these findings suggest that overexpression of ITGA V is closely associated with metastasis and progression of ESCC. Therefore, we suppose that ITGA V could be an effective prognostic marker in individualized treatment of patients with ESCC.