{'fraction_non_alphanumeric': 0.026170798898071626, 'fraction_numerical': 0.011019283746556474, 'mean_word_length': 5.433628318584071, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Cytogenetic evidence of gene amplification in urothelial cancer--a possible mechanism of tumor invasiveness.

A cytogenetically detectable form of gene amplification, presumably oncogene amplification, double minute chromosomes, has been found in 11 out of 45 specimens (24%) of moderately and poorly differentiated, deeply infiltrating transitional cell carcinoma of the bladder and ureter. None of the 75 low-grade low-stage tumors contained this karyotypic anomaly. It is obvious that double minutes are not a rare and sporadic phenomenon in this type of tumors; additionally there is strong evidence that they are involved in tumor progression, i.e. they are associated with tumor aggressiveness and unfavorable prognosis.