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Sexual Dimorphism in obsessive-compulsive disorder

Since then, several publications have presented data lending further support to the sexual dimorphism hypothesis. Thus, two papers (Mundo et al. 1999, 2002) have claimed that there is a differential behavioural and biochemical response to clomipramine among OCD patients. Other studies have shown that association and/or linkage to genetic markers of OCD are different in male and female patients (Nestadt et al. 2000; Alsobrook et al. 2002; Lochner et al. 2004). Lately, a basic animal study has shown sex differences in the performance of an alternation task, supposedly an animal model of OCD (Ulloa et al. 2004).