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Polymorphous light eruption

Polymorphous light eruption (PMLE) was first recognized as a unique photodermatosis in the early 20th century, although it is sometimes difficult to distinguish PMLE from other idiopathic photodermatoses, such as actinic prurigo. PMLE lesions also resemble those commonly observed in lupus erythematosus, and several recent studies have suggested that the two conditions may share a common pathogenesis. PMLE is the most common idiopathic photodermatosis observed in dermatology clinics, but few studies have provided population-based prevalence estimates. The few studies that have been conducted suggest that the prevalence of PMLE is 10–20% in European and North American populations. Many people may be aware of a “sun rash” or “sun allergy,” but never seek medical attention for their symptoms. Often PMLE symptoms are mild and transient, appearing only in early spring or during vacations to sunny or high-altitude locales. Most of the published information about PMLE comes from small studies of clinical cases, and the potential for various selection biases is therefore a concern when interpreting the results of these studies.