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Antioxidant Metabolites from the Stems of Bakeridesia gaumeri

Bakeridesia gaumeri is an endemic plant of the Yucatan peninsula, where it is used in traditional medicine for the treatment of dysentery, enterocolitis and diarrhea. The stem extract of the plant showed significant antioxidant activity in the DPPH free radical scavenging assay. Bioassay-guided fractionation of the crude extract resulted in the isolation and identification of 7-hydroxycadalenal (1, EC50 0.85 ± 0.06 mM) and trans-clovamide (2, EC50 0.15 ± 0.01 mM) as the metabolites responsible for the antioxidant activity of the crude extract.