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The Cornelia de Lange Syndrome (Continued)

A recent communication by Pashayan, Levy, and Fraser1 stressed a valid point that some features of the Cornelia de Lange syndrome may not be as obviously unusual in early infancy as later; in some cases the infant with this disorder may occasionally go undiagnosed until the features are prominent enough to suggest a secure diagnosis. For example, sequential pictures of cases reported by Opitz, et al. (Patient S. St.)2 and Beer, et al. (Case I)3 demonstrate the worsening of the facial characteristics over varying periods of observation.