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[Studies on the cellular immunological response in splenectomized or autotransplanted mice].

Splenectomy is known to increase the risk of overwhelming bacterial infection. The spleen seems to play an important role in host defence mechanisms. Recently, a number of studies on the role of the spleen employing human subjects as well as experimental animals have been carried out. However, the results are controversial. In this study, the effect of splenectomy and splenic autotransplantation on cell-mediated immunity were examined by evaluating mitogen and antigen induced proliferation of murine peripheral lymph node cells. The results obtained were as follows : 1) The proliferative response of peripheral lymph node cells to PHA and OCB-BGG in sple-nectomized mice seemed to be greater as compared with that in sham-operated mice at the 6 th and 8 th week after the operation. 2) Lymphocyte subpopulation of peripheral lymph node using monoclonal antibodies was carried out in order to investigate the cause of the highly proliferative response of the lymphocytes in the splenectomized mice. The total number of T-and B-cell population and that of helper and suppressor T-cell subpopulation were measured respectively. However, no significant difference was observed between splenectomized and sham-operated groups. 3) In the mice of one-third splenic tissue was autotransplanted to the omental pouch a complete regenerative finding was observed histologically at the 8 th week after the operation and the normal immunological reactivity was observed in the autotransplanted group of mice as well as the sham-operated group of mice.