Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Abteilungen OPUS4-47371 Wissenschaftlicher Artikel Trog, S.; El-Khatib, Ahmed; Beck, S.; Makowski, M.; Jakubowski, Norbert; Linscheid, M. Complementarity of molecular and elemental mass spectrometric imaging of Gadovist™ in mouse tissues Drug biodistribution analyses can be considered a key issue in pharmaceutical discovery and development. Here, mass spectrometric imaging can be employed as a powerful tool to investigate distributions of drug compounds in biologically and medically relevant tissue sections. Both matrix-assisted laser desorption ionization-mass spectrometric imaging as molecular method and laser ablation inductively coupled plasma-mass spectrometric imaging as elemental detection method were applied to determine drug distributions in tissue thin sections. Several mouse organs including the heart, kidney, liver, and brain were analyzed with regard to distribution of Gadovist™, a gadolinium-based contrast agent already approved for clinical investigation. This work demonstrated the successful detection and localization of Gadovist™ in several organs. Furthermore, the results gave evidence that gadolinium-based contrast agents in general can be well analyzed by mass spectrometric imaging methods. In conclusion, the combined application of molecular and elemental mass spectrometry could complement each other and thus confirm analytical results or provide additional information. Springer 8 Elemental and Molecular Imaging by LA-ICP-MS 411 3 629 637 10.1007/s00216-018-1477-9 1 Analytische Chemie; Referenzmaterialien OPUS4-47130 Wissenschaftlicher Artikel El-Khatib, A. H.; Radbruch, H.; Trog, S.; Neumann, B.; Paul, F.; Koch, A.; Linscheid, M. W.; Jakubowski, Norbert; Schellenberger, E. Gadolinium in human brain sections and colocalization with other elements Recent recommendations by the Food and Drug Administration1 and the European Medicines Agency2 are to limit the clinical use of linear gadolinium-based contrast agents (GBCAs) due to convincing evidence of deposition in tissues. Macrocyclic GBCA continued to be considered safe, provided that patients have normal renal function. To date, given the low sensitivity of conventional MRI, there has been a debate about the signal increase following the injections of a macrocyclic GBCA. American Academy of Neurology NaN Neurology(R) neuroimmunology & neuroinflammation 6 1 e515, 1 3 urn:nbn:de:kobv:b43-471309 10.1212/NXI.0000000000000515 1 Analytische Chemie; Referenzmaterialien