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DiscoveryProbe™ Membrane Transporter/Ion Channel-related Compounds Panel

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A wide range of well-characterized bioactive molecules that covers various targets related to membrane transporter/ion channel, including ATPase, calcium channel and CFTR etc. Facilitate your research towards the insights of heart diseases, cystic fibrosis and immune disorders etc. Applicable in cellular assays, animal models and drug screenings etc.

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Related Biological Data


Related Biological Data

Ivacaftor inhibits mutant CFTR.

Related Biological Data



Available in stock with overnight delivery and free shipping over $500 Cost-effective and competitive price to save your findings Potent, selective and cell-permeable in inhibiting or activating target molecules Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.) Detailed files describing potency, selectivity and applications etc. Supported by published data from top peer-reviewed journals Guaranteed high quality with NMR and HPLC validation

Featured Products of the Panel

Catalog No. Product Name Summary Targets CAS Number Smiles
A8455 Nilvadipine Potent calcium channel blocker Membrane Transporter/Ion Channel|Calcium Channel 75530-68-6 CC1=C(C(C(=C(N1)C#N)C(=O)OC)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC(C)C
A8351 VX-809 CFTR corrector Membrane Transporter/Ion Channel|CFTR 936727-05-8 CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
A1855 Bumetanide Inhibitor of Na+/K+/Cl- cotransporter Membrane Transporter/Ion Channel|NKCC 28395-03-1 CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2
A3100 (+)-MK 801 Potent NMDA antagonist Membrane Transporter/Ion Channel|NMDA Receptor 70449-94-4 C[[email protected]]1(N2)C3=C(C=CC=C3)C[[email protected]@H]2C4=C1C=CC=C4
A3532 KN-93 CaMKII inhibitor,selective and competitive Membrane Transporter/Ion Channel|P2X purinergic receptor 139298-40-1 CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC
B7659 Psora 4 Potent KV1.3 channel blocker Membrane Transporter/Ion Channel|Potassium Channel 724709-68-6 O=C1OC2=C(C=C1)C(OCCCCC3=CC=CC=C3)=C4C(OC=C4)=C2
B4798 Procainamide HCl Na+ channel blocker; DNA methyltransferase 1 inhibitor Membrane Transporter/Ion Channel|Sodium Channel 614-39-1 CCN(CC)CCNC(=O)C1=CC=C(C=C1)N.Cl
A8519 SB705498 TRPV1 antagonist,potent and selective Membrane Transporter/Ion Channel|TRPV1 501951-42-4 C1CN(CC1NC(=O)NC2=CC=CC=C2Br)C3=NC=C(C=C3)C(F)(F)F
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1. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol. 2003 Jul;4(7):517-29.
Ca2+ is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes. Rapid highly localized Ca2+ spikes regulate fast responses, whereas slower responses are controlled by repetitive global Ca2+ transients or intracellular Ca2+ waves. Ca2+ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.
2. Sajja RK, Cucullo L. Altered glycaemia differentially modulates efflux transporter expression and activity in hCMEC/D3 cell line. Neurosci Lett. 2015 Jun 26;598:59-65.
The impact of diabetes on BBB efflux transporters is less understood. In this study, we examined the effects of single or repeated episodes of hypo-and hyperglycemia on major BBB efflux transporters expression/function in human cerebromicrovascular endothelial cell line (hCMEC/D3). this study suggests a differential impact of altered glycemic conditions on major BBB drug efflux transporters expression/function, sensitive to the length of exposure (acute vs. repeated), with an implication for altered CNS drug disposition in diabetic population.