Multiple Myeloma Signs & Symptoms


  • Fatigue
  • Infection: Because myeloma cells crowd out normal white blood cells, which fight infection, there is a risk of infection. Symptoms depend on where the infection is. Pneumonia, bladder or renal infections, sinusitis and skin infections are common.
  • Blood problems, including low levels of white or red blood cells or platelets.
  • Renal failure or “myeloma kidney” caused by too much protein or calcium in the blood.
  • Many organs can be affected by multiple myelom. The signs and symptoms can vary greatly. The mnemonic CRAB is often used to remember some of the common symptoms: C = calcium (elevated), R = renal failure, A = anemia, B = bone lesions.



Unfortunately, no standardized screening tests have been shown to improve multiple myeloma outcomes. However, here at Banner MD Anderson, we’re working to develop tests to detect multiple myeloma earlier.