@article {Matschinsky647, author = {Matschinsky, Franz M}, title = {Glucokinase as Glucose Sensor and Metabolic Signal Generator in Pancreatic β-Cells and Hepatocytes}, volume = {39}, number = {6}, pages = {647--652}, year = {1990}, doi = {10.2337/diab.39.6.647}, publisher = {American Diabetes Association}, abstract = {This article reviews evidence for a pivotal role of glucokinase as glucose sensor of the pancreatic β-cells. Glucokinase explains the capacity, hexose specificity, affinities, sigmoidicity, and anomeric preference of pancreatic islet glycolysis, and because stimulation of glucose metabolism is a prerequisite of glucose stimulation of insulin release, glucokinase also explains many characteristics of this β-cell function. Glucokinase of the β-cell is induced or activated by glucose in contrast to liver glucokinase, which is regulated by insulin. Tissue-specific regulation corresponds with observations that liver and pancreatic β-cell glucokinase are structurally distinct. Glucokinase could play a glucose-sensor role in hepatocytes as well, and certain forms of diabetes mellitus might be due to glucokinase deficiencies in pancreatic β-cells, hepatocytes, or both.}, issn = {0012-1797}, URL = {https://diabetes.diabetesjournals.org/content/39/6/647}, eprint = {https://diabetes.diabetesjournals.org/content/39/6/647.full.pdf}, journal = {Diabetes} }