Rat Anti-Mouse CCL-6

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Size100 µg
Price275 €
CategoryMonoclonal Antibody
Clone Nr.(#7J13)
Species ReactivityMouse
Antigenrecombinant mouse CCL-6
ApplicationWB, N
SynonymsCcl6; c10; MRP-1; Scya6
DescriptionMouse CCL6, a member of the β subfamily of chemokines, was initially identified as a transcript that is induced in bone marrow cells upon stimulation with GM-CSF. A human homologue for mouse CCL6 has not been identified. The mCCL6 cDNA encodes a 116 amino acid residue precursor protein with a hydrophobic signal peptide that is cleaved to yield a 95 amino acid residue mature protein. Compared to other chemokines, mCCL6 has a large N-terminal extension. The expression of CCL6 mRNA has been detected in mouse monocytes and neutrophils, where it is strongly induced upon GM-CSF stimulation. CCL6 expression has also been detected in an IL2-dependent T cell line, where the expression is inhibited following T cell stimulation. Mouse CCL6 expression was also shown to be strongly induced by IL-4 in mouse macrophages. The gene for CCL6 has been mapped to mouse chromosome 11.
Uniprot IDP27784
Protein RefSeqNP_033165
mRNA RefSeqNM_009139

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