Monodemethylimipramine en es it fr

Monodemethylimipramine Brand names, Monodemethylimipramine Analogs

Monodemethylimipramine Brand Names Mixture

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Monodemethylimipramine Chemical_Formula


Monodemethylimipramine RX_link


Monodemethylimipramine fda sheet

Monodemethylimipramine FDA

Monodemethylimipramine msds (material safety sheet)

Monodemethylimipramine MSDS

Monodemethylimipramine Synthesis Reference

No information avaliable

Monodemethylimipramine Molecular Weight

266.381 g/mol

Monodemethylimipramine Melting Point

214-218 oC

Monodemethylimipramine H2O Solubility

No information avaliable

Monodemethylimipramine State


Monodemethylimipramine LogP


Monodemethylimipramine Dosage Forms


Monodemethylimipramine Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression.

Monodemethylimipramine Pharmacology

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

Monodemethylimipramine Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

Monodemethylimipramine side effects and Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg

Monodemethylimipramine Patient Information

No information avaliable

Monodemethylimipramine Organisms Affected

Humans and other mammals