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RADIOPROTECTIVE EFFECT OF HUMAN LACTOFERRIN AGAINST GAMMA-IRRADIATION WITH SUBLETHAL DOSE

The aim of this study was to investigate the effects of human lactoferrin (hLf) in mice exposed to acute sublethal gamma-irradiation. C57Вl/6 male mice were used for the experiments. Animals from experimental groups were exposed to whole-body gamma-radiation at a dose of 7.5 Gy. Some animals received an intraperitoneal injection of lactoferrin (Lf) immediately and then at 24 hours after the irradiation. The effect of Lf on survival rate and life span was studied. Changes in the physiological parameters were evaluated by laser correlation spectroscopy of blood serum, histological examination of the liver, and blood leukocyte shift index count on day 30 after irradiation. The Lf administration increased the survival rate and life span of irradiated mice during the experiment. In addition, Lf had a compensatory effect on the white blood formula, serum composition and liver condition of irradiated animals.