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5HT2 Receptor‐Mediated Function in Depressed Patients: Investigation by Measuring SHT‐Induced Shape Change of Blood Platelets

Abstract: The SHT‐induced shape change (SHT‐SC) of blood platelets, which had been suggested to reflect the SHTs receptor‐mediated function of the central nervous system (CNS), was examined in patients with depression before or after antidepressant therapy. The degree of SHT‐SC did not differ between patients before treatment (n = 17) and healthy controls (n = 26). In patients after treatment (n = 12), in whom depression had been improved but drug therapy was continued, SHT‐SC in a concentration of 10–5 M SHT was observed more potently than that in healthy controls or untreated patients (p < 0.05 and p < 0.05, respectively). In 4 patients in whom SHT‐SC was measured before and after mianserin treatment, SHT‐SC increased after the treatment. These results suggest that the SHT2 receptor‐mediated function in the CNS may not be demaged in patients with depression, and that the 5HT2 receptor‐mediated function in the CNS may be enhanced by antidepressants.