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Antiarrhythmic Effect of Water Extraction Liquid of Clivia

Objective:To observe the antiarrhythmic effects of water extraction liquid of clivia (WELC). Method:Chemical drug induced arrhythmic models and coronary ligation induced arrhythmic models were used to investigate anti arrhythmic effects of WELC. Results:WELC 6 g·kg 1 and 12 g·kg 1 could inhibit markedly the ventricular arrhythmias induced by aconitine 20 μg·kg 1 or BaCl 2 2 mg·kg 1 or coronary ligation in rats. WELC also obviously reduced the incidence of atrium fibrillation produced by CaCl 2 Ach (CaCl 2 0.6%+Ach 0.002 5%) 10 mL·kg 1 in mice. These actions were similar to quinidine. The ECG of rats demonstrated that after iv administration of WELC 6 g·kg 1 , the heart rate was slowed down, and the P R and Q T intervals were prolonged. Conclusion:WELC has obvious antiarrhythmic effects in rats.