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Sestrins as modulators of aging processes and diseases
related to age

Sestrins are highly conserved proteins that regulate cell growth, metabolism, survival
and proliferation under oxidative stress, genotoxic stress, hypoxia or endoplasmic
reticulum stress. Sestrins affect cell signaling by inhibiting the production of reactive
oxygen species, activating the AMP-activated protein kinase (AMPK), inhibiting
the mTOR pathway and acting as a positive regulator of autophagy. Therefore, their protective
role against cancer, metabolic disorders, cardiovascular diseases and neurodegeneration
is increasingly being postulated. The article describes the mechanisms of
action of sestrins and their meaning in aging and age-related diseases. The latest studies
indicating their physiological significance and role in key signaling pathways controlling
the cell metabolism and survival under stress conditions were also discussed.

