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Understanding the role of force , mechanics , and biological machinery — the “ mechanome ” — will open the way to new strategies for fighting disease . Lighting Up the Mechanome

biological machinery—the " mechanome " —will open the way to new strategies for fighting disease. Genomics and general " omics " approaches, such as proteomics, inter-actomics, and glycomics, among others, are powerful system-level tools in biology. All of these fields are supported by advances in instrumentation and computation, such as DNA sequencers and mass spectrometers, which were critical in " sequencing " the human genome. Revolutionary advances in biology that have harnessed the machinery of polymerases to copy DNA or used RNA interference to capture and turn off genes have also been critical to the development of these tools. Researchers in biophysics and bio-mechanics have made significant advances in experimental methods, and the development of new microscopes has made higher resolution molecular-and cellular-scale measurements possible. Despite these advances, however, no systems-level " omics " perspective— the " mechanome " —has been developed to describe the general role of force, mechanics, and machinery in biology. Like the genome, the mechanome promises to improve our understanding of biological machinery and ultimately open the way to new strategies and targets for fighting disease. Many disease processes are mechanical in nature. Malaria, which infects 500 million people and causes 2 million deaths each year, works through a number of mechanical processes, including parasite invasion of red blood cells (RBCs), increased RBC adhesions, and overall stiffening of RBCs. As the disease progresses, it impairs the ability of infected cells to squeeze