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Evaluation of Hepatoprotective Potential of Leaf Extracts of Some Medicinal Plants Using HepG2 Cell line

The present study was carried out to evaluate the hepatoprotective activity of Adina cordifolia, Careya arborea, Cassia angustifolia, Hiptage benghalensis and Lannea coromandelica against alcohol induced toxicity using HepG2 cell lines. Prior to the determination of hepatoprotective property, leaf extracts were subjected to the toxic dose study. The degree of hepatoprotection of extracts was determined by measuring cell viability percentage by MTT assay. The preliminary phytochemical analysis of leaf extracts was carried out by qualitative analysis. HepG2 cells were pretreated with the different concentrations (below toxic dose) of leaf extracts for 72 hours followed by alcohol intoxication. Results revealed that Cassia angustifolia ethanolic leaf extract pretreated HepG2 cells show 92% cell viability compared to the standard silymarin pretreated HepG2 cells which showed 80% cell viability. Out of the other plants tested, Adina cordifolia exhibited the significant hepatoprotection. The bio-efficacy study confirms the presence of promising secondary metabolites of hepatoprotective nature in leaf extracts of Cassia angustifoliaand Adina cordifolia.