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The long noncoding RNA uc.294 is upregulated in early‐onset pre‐eclampsia and inhibits proliferation, invasion of trophoblast cells (HTR‐8/SVneo)

Recently, a large number of long noncoding RNAs (lncRNAs) have been reported in human diseases that are evolutionarily conserved and are likely to play a role in many biological events including pre‐eclampsia. In our previous research, we selected thousands of lncRNAs for their relationship with early‐onset pre‐eclampsia. Among these lncRNAs, a lncRNA named uc.294 attracted our attention, was once reported to specifically be expressed at a high level in the early‐onset of pre‐eclampsia. This study aims to investigate the function of uc.294 in early‐onset pre‐eclampsia and the possible mechanism. The uc.294 expression level in early‐onset pre‐eclampsia or in normal placenta tissues was evaluated by quantitative real‐time polymerase chain reaction. To detect the proliferation, invasion, and apoptosis capacity of the trophoblast cells, we performed the Cell Counting Kit‐8 assay, transwell assay, and flow cytometry, respectively. Here we report, for the first time, that uc.294 inhibits proliferation, invasion, and promotes apoptosis of trophoblast cells HTR‐8/SVneo by working in key aspects of biological behaviors. However, how uc.294 acts to regulate gene functions in early‐onset pre‐eclampsia needs further exploration.