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Lysine and Pipecolic Acid Metabolism in the Domestic Fowl 1

Summary Experiments were conducted with colostomized adult Leghorn pullets to determine the urinary excretion products produced from the metabolism of d- and l-lysine and l–pipecolic acid. The results indicate that the fowl, unlike the rat, excretes very little free pipecolic acid after an intraperitoneal dose of either d-lysine or l-pipecolate. The urine was analyzed for an ornithine conjugate of pipecolic acid or a degradation product of lysine metabolism. None was detected. It was concluded that the increase in the chicken's requirement for arginine when surfeit lysine is consumed is not due to a need for ornithine to detoxify a lysine metabolite.