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[The clinicopathological features and surgical treatment of solitary fibrous tumor of the pleura].

OBJECTIVE
To investigate the clinicopathological features and surgical treatment of solitary fibrous tumor of the pleura (SFTP).


METHODS
The clinical, radiological and pathological features of 11 cases of SFTP were analyzed. The detection of immunohistochemistry, surgical treatment and follow-up data were also reviewed.


RESULTS
The group consisted of 6 males and 5 females, age ranging from 35 to 73 years (mean 53.7 years). Clinical findings were mainly cough, chest pain and other local symptoms. Five cases had pleural effusion. Surgical excision was performed by thoracotomy in 6 patients, by video-assisted thoracoscopic surgery (VATS) in 3 patients, and by VATS plus a small thoracotomy in 2 patients. Eight cases received tumor resection by wedge resection of the lung, and the other 3 patients by middle and lower lobe resection, lower lobe resection and chest wall tumor resection, respectively. Nine tumors were located in the visceral pleura, 1 tumor below the visceral pleura, and 1 tumor in parietal pleura. Histopathologically, SFTP consisted mainly of spindle-shaped cells which were diffusely distributed. There were abundant gross collagenous fibers and thick-walled blood vessels around tumor cells. Malignant tumors displayed high cell density, nuclear atypia and patho-karyokinesis. The tumor cells were stained with vimentin (100%, 11/11), CD(34) (100%, 11/11), CD(99) (63.6%, 7/11), and bcl-2 (63.6%, 7/11), but no expression of CD(31). Of the 11 cases, 9 were histologically diagnosed as benign SFTP, 1 as cell-abundant type of SFTP, and another as malignant SFTP. One patient died of multiple organ failure after surgery. The mean duration of hospital stay after surgery was 11 days. Follow-up visit results were available for 10 cases. The follow-up time ranged from 12 to 48 months and all patients remained well without recurrence or metastasis.


CONCLUSIONS
SFTP should be considered when chest X-ray and CT showed single nodule or mass in the pleura. The diagnosis is based on examination of histopathology and immunohistochemistry. For a tumor with a diameter les than 5 cm, resection by VATS or VATS plus small thoracotomy is a good surgical procedure.