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Complicated appendicitis is predicted by the presence of systemic inflammatory response syndrome

Context: Systemic inflammatory response syndrome (SIRS) can be a result of ischemia, inflammation, trauma, infection, or a combination of several “insults.” Aims: The present study aims to estimate the relationship between SIRS and different predictive factors including sex, renal disease, diabetes (DM), comorbidities ultrasound, computed tomography (CT) abdomen, operative intervention, and other operational findings of inflamed appendicitis, gangrenous and perforated appendicitis, and postoperative complications. Settings and Design: Retrospective cohort study was conducted at Al-Noor Hospital Emergency Department in Makkah. Materials and Methods: Data were collected from 259 patients with acute appendicitis presented to the Al-Noor Hospital Emergency Department in Makkah during 1435H. Variables such as comorbidities, vital sign on presentation, the result of certain investigation (white blood cell count, arterial blood gas, ultrasound, and CT abdomen), interventions provided, postoperative complication, intensive care unit length stay, and outcome along with SIRS criteria were followed to collect the data. Statistical Analysis Used: A secondary logistic analysis was also performed (SPSS version 19.0) on key risk factors, in order to exclude confounding covariates. Results: The findings of the study indicate a significant relation between SIRS criteria and the operation findings of perforation with collection with a significant P = 0.001. The presence of gangrenous appendicitis intraoperatively provided almost significant relationship with SIRS criteria (0.065). Conclusion: The present study concluded that SIRS has a significant predictive value with the presence of complicated appendicitis in the form of perforation and gangrene.