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Efficacy of tofacitinib in treatment of alopecia universalis in two patients

Autoimmune‐triggered non‐scarring hair loss is a feature of alopecia areata (AA). Initially patchy and often self‐limited, severe hair loss forms include the complete loss of scalp hair or alopecia totalis (AT) and complete loss of all hair or alopecia universalis (AU). For AT and AU a reliable treatment has remained elusive. The targeted kinase inhibitor tofacitinib, in current use for treatment of other immune diseases, has been hypothesized as a viable option for AA, AT and AU therapy and a few case reports support this.