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Drosophila and mammalian circadian systems: Similarities on the surface, some differences at the core

No model systems have contributed more to our understanding of underlying mechanisms than Drosophila and nocturnal rodents. Much about the underlying molecular and cell biology of the circadian clocks are similar and this has sped discovery of the mechanisms of rhythm generation. At higher levels of organization the timing systems of mammals and flies differ in fundamental ways. These differences provide comparative insights into the adaptive nature of circadian timing systems.