{'fraction_non_alphanumeric': 0.03109182935647144, 'fraction_numerical': 0.010845986984815618, 'mean_word_length': 5.348623853211009, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
The relation between the expression of tumor necrosis factor-α and soluble tumor necrosis factor receptor in early prognancy and the spontaneous abortion

Objective To investigate the relation between the expression of tumor necrosis factor α(TNF α) and soluble tumor necrosis factor receptor (sTNFR) in early pregnancy and spontaneous abortion. Methods Chorionic villi and decidua and serum of first trimester were obtained from 20 normal pregnancies, 20 the first time spontaneous abortion(SA) and 15 recurrent spontaneous abortion(RSA) cases. The expression of TNF α was detected using immunohistochemical staining (S P), sTNFR were measured by sandwich ELISA. Results ①)TNF α expression in the cytotrophoblasts and decidua of SA and RSA were signigicantly higher than that of normal early pregnancy (P0.05). In the syncytiotrophoblasts, TNF α expression of normal early pregnancy was similar to that of SA and it's significantly higher than RSA. ②The seurm sTNFRⅠ,sTNFRⅡof SA were significantly higher than those in the control group (P0.05), sTNFRⅠand sTNFRⅡin RSA were significantly higher than those in the SA (P0.05). Conclusions TNF α, sTNFR are associated with the oncogenesis and development of spontaneous abortion. An elevated expression of TNF α may be a cause of spontaneous abortion and there are important practical values to the elevated expression of sTNFR.[