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Conformational flexibility in DNA structure as revealed by structural studies of drug intercalation and its broader implications in understanding the organization of DNA in chromatin.

This paper reviews evidence for conformational flexibility in DNA structure (i.e., the kink) as revealed by structural studies of drug intercalation. It then describes the implications these concepts have in understanding the organization of DNA in chromatin. It is possible that the kink has still broader meaning in understanding the nature of protein-DNA interactions that are important in RNA transcription and DNA replication.