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Two consistently deleted regions within chromosome 1p32‐pter in human non–small cell lung cancer

Allelic losses at 1p32‐pter have been reported as frequent events in human non–small cell lung cancer (NSCLC). To further characterize the region of deletions, we studied loss of heterozygosity on a panel of 102 microdissected NSCLC samples with 20 polymorphic markers spanning 1p32‐pter. Two shortest regions of the overlap of the deletions (SROs) were found: SRO 2a (D1S417–D1S57) and SRO 2b (D1S450–D1S243). Allelic losses at either region correlated independently with advanced stage of disease and with postoperative metastasis and relapse (P < 0.05), suggesting that crucial genes in these regions are involved in NSCLC progression. Mol. Carcinog. 30:151–158, 2001. © 2001 Wiley‐Liss, Inc.