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Book Review: Advances in Renal Physiology

The second edition of this book is greatly expanded and is an admirable attempt to make a great text even better. In addition to updating previous chapters, new chapters include population and Bayesian pharmacokinetics, induction and inhibition of drug metabolism, protein binding and unbound drug concentrations, kinetics in elderly and pediatric patients, and the following drug-specific topics: chloramphenicol, antiepileptic drugs, beta blockers, ranitidine, cyclosporine, and warfarin. As usual for this book, chapters are authored by individuals who not only are clinical experts but also have conducted a substantial amount of research with the drug. This distinction allows the authors to give unusual insight into the use of the individual drugs. Several chapters with additional commentaries (short counterpoint chapters written by other authors who express a different point of view) allow the reader to develop different perspectives. This book is the standard by which other texts on clinical pharmacokinetics should be measured. As a complement to one of the other excellent texts on basic pharmacokinetics (such as Pharmacokinetics, Second Edition by Gibaldi and Perrier at the graduate or advanced Pharm.D. levels or Biopharmaceutics and Clinical Pharmacokinetics, Fourth Edition by Notari at the undergraduate level), this book should be on the desk of every pharmacokinetics practitioner or researcher. It would also be very useful as a textbook in a class on clinical pharmacokinetics at any level. Pharmacists, physicians, and other clinicians who need a good source of information on applied kinetics would also benefit from this book.