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Intravascular haemolysis, platelet consumption and platelet adhesiveness in patients with prosthetic heart valves.

Patients with increased haemolysis following insertion of heart valve prostheses showed a significantly increased platelet consumption and a marked decrease of adhesive platelets. Possibly, adhesive platelets are consumed by formation of platelet thrombi on the artificial valves. The high prevalence of thrombo-embolism in patients with ball valves might be explained by such a mechanism.