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Association of Serum Galectin-3 Level with Albuminuria and Renal Function in Type 2 Diabetic Iraqi Patients

Background : Galectin-3 is a category of β- galactoside binding Lectin. It has been involved in renal inflammation and fibrosis. We examined the relationship between galectin-3 level and nephropathy in T2DM patients with or without microalbuminuria in comparison healthy controls. Methods : Ninety T2DM patients they were graded as (3 groups) depending on (ACR) albumin to creatinine value: normalbuminuria (ACR < 30 mg / g), micro albuminuria (ACR 30-300 mg / g); and macroalbuminuria (ACR > 300 mg / g). In addition, 30 healthy control subject. The serum galectin-3 was determined by an enzyme-linked immune sorbent assay (ELISA) for 90 T2DM patients and 30 healthy subjects. And also biochemical parameters measured included FBG, HbA1c, urea, creatinine, and uric acid. Result: Serum galectin-3 was significantly raised in T2DM patients with macroalbuminuria in comparing to healthy group and also to other patients groups (p<0.001). Galectin-3 level was positively related with each of ACR, FBS, HbA1c, urea, creatinine. whilst, eGFR was negatively correlated with galectin-3 Conclusion : Galectin-3 level is essentially higher with T2DM at all stages of DN, particularly in macroalbuminuria patients.