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Retrospective analysis of the efficacy of controlled internal drug release in follicular cysts in an embryo donor beef herd.

We investigated the efficacy of a controlled internal drug release (CIDR) device in the reproductive management of an embryo donor beef herd. Superovulation of embryo donors was routinely induced by a combination of FSH and prostaglandin F(2)alpha analogue (PGF(2)alpha) at intervals of a few months, and after embryo recovery estrus of the donors was synchronized with PGF2(2)alpha. Between 1996 and 1998, approximately 20% of donors were diagnosed as having follicular cysts every year. Twenty-eight cases of follicular cysts recorded between 1997 and 1998 were treated with a CIDR device for 14 days to evaluate the efficacy of CIDR in resolving follicular cysts in donor herds. Initial recovery was defined as the occurrence of ovulation with estrous behavior and subsequent formation of a corpus luteum after removal of the CIDR. Initial recovery was recognized in all cases (n=28). Follicular cysts did not recur after repeated embryo recovery in 64% of the initially recovered donors, but in 36% of affected donors cysts recurred after the next embryo recovery. Subsequently, with a CIDR device instead of PGF(2)alpha, we synchronized estrus after embryo recovery in the same herd from 1999 to 2000, to investigate the ability of CIDR to prevent the initiation of follicular cysts. Of the donors used between 1999 and 2000, approximately 30% had a history of follicular cysts. Use of CIDR for estrous synchronization after embryo recovery lowered the incidence of follicular cysts to 3% in 1999 and 0% in 2000. Treatment with CIDR proved effective at resolving follicular cysts in the embryo donor beef herd and enabled re-use of donors affected with follicular cysts. CIDR is also likely to be efficacious in lowering the occurrence of follicular cysts in donor herds when it is used for estrous synchronization after embryo recovery.