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A permissive effect of cyclosporin on the development of isohaemagglutinins of graft origin in ABO-mismatched organ transplantation.

Acquired immunhaemolytic anemia is a rare but potentially hazardous phenomenon in ABO-mismatched allograft recipients. We report on a further patient, in whom severe haemolytic anemia developed due to a highly specific anti-A1 'auto' antibody of IgG class, after receiving an ABO-mismatched kidney graft. The possible role of immunosuppressive medication in the generation and limitation of this immune disease is discussed.