{'fraction_non_alphanumeric': 0.033144704931285365, 'fraction_numerical': 0.012934518997574777, 'mean_word_length': 5.655913978494624, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Rapidly Progressive Dementia as Presenting Feature in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), primarily known as Crohn disease and ulcerative colitis, encompasses a group of idiopathic intestinal disorders with complex pathogenesis. Extraintestinal manifestations affecting various organs, such as the skin, eyes, joints, bone, blood, kidney, liver, and the biliary tract are observed in 20% to 40% of patients with IBD.1 Neurological complications associated with IBD have been reported, with the incidence varying from 0.25% to 35.7%.2 To date, however, only a few studies have reported cognitive impairment in association with IBD, such as Wernicke encephalopathy, vasculitis, and acute confusional state.2–5 Recent advances in the diagnosis and treatment of rapidly progressive dementia (RPD) have led to the recognition that RPD has many causes including neurodegenerative, autoimmune, infectious, and toxic metabolic conditions.6 We report 2 cases of RPD as presenting feature in a patient with Crohn disease and another patient with intermediate type of colitis (ie, a disease with “clear” evidence of IBD but insufficient evidence to make a definite diagnosis of either ulcerative colitis or Crohn disease).