{'fraction_non_alphanumeric': 0.07147147147147147, 'fraction_numerical': 0.05525525525525526, 'mean_word_length': 5.036231884057971, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
FDG PET or PET/CT for Detecting Intramedullary and Extramedullary Lesions in Multiple Myeloma: A Systematic Review and Meta-analysis

Aim The purpose of the current study was to conduct a systematic review and meta-analysis of the published literature to evaluate the diagnostic accuracy of FDG PET or PET/CT for intramedullary and extramedullary lesions in multiple myeloma. Methods The authors conducted a systematic MEDLINE search of published articles. Two reviewers independently assessed the methodological quality of each study. We estimated pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR−), and summary receiver operating characteristic curves in the detection of intramedullary and extramedullary lesions in multiple myeloma. Results Fourteen studies with a total of 395 patients met the inclusion criteria. The pooled estimates of sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of FDG PET or PET/CT for the detection of extramedullary lesions in multiple myeloma were 96.0% [95% confidence interval (CI), 79.6%–99.9%], 77.8% (95% CI, 40.0%–97.2%), 3.28 (95% CI, 1.29–8.32), and 0.12 (95% CI, 0.03–0.42), respectively. The pooled estimates of sensitivity, specificity, LR+, and LR− of FDG PET or PET/CT for the detection of intramedullary lesions in multiple myeloma were 61.1% (95% CI, 43.5%–76.9%), 94.1% (95% CI, 71.3%–99.9%), 5.73 (95% CI, 1.53–21.40), and 0.43 (95% CI, 0.28–0.65), respectively. Conclusions Whole-body FDG PET or PET/CT is a valuable imaging tool for the assessment of patients with multiple myeloma, especially for the appraisal of extramedullary involvement.