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Use of dietary exposure modelling to estimate the intake of artificial sweeteners by young children with medical conditions

The range of foods available to individuals with particular medical conditions e.g. inborn errors of metabolism (Phenylketonuria, PKU) or severe cow’s milk protein allergy (CMPA) is so limited that they must rely on specially formulated products to meet their nutrition requirements. Patients with PKU or CMPA have dietary restrictions along with exclusive or partial replacement with special formulations. Artificial sweeteners are used to improve the appearance and palatability of these formulations. Young children have a higher risk of exceeding acceptable daily intakes (ADI) for additives than adults due to higher food intakes per kg body weight 2, . The aim was to use dietary exposure modelling to estimate the intake of artificial sweeteners by young PKU and CMPA patients (1–3 years). To date, none of the exposure models available have addressed additive intakes in young patients. EFSA’s recently launched Food Additives Intake Model is not equipped to assess partial dietary replacement with special formulations. A new approach is needed. Food consumption data for patients are not readily available. Data used for analysis are derived from the food consumption survey data of healthy young children as a baseline. The National Preschool and Nutrition Survey (NPNS) was designed to assess the diet, nutrient intake and nutritional status of the healthy Irish children aged 1–4 years. The population of interest was young children aged from 1–3 years (376 subjects). The food groups used for data collection in this study are the 17 EU food categories. An adapted validated probabilistic model was used to assess patients’ exposure to artificial sweeteners 5, . Specially formulated products were included in the exposure model to replace restricted foods. Inclusion was based on recommendations for adequate protein intake and dietary adherence data. The exposure assessment results indicate young Irish patients with PKU and CMPA have higher relative average intakes of artificial sweeteners than healthy young children (see tables).