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A Novel Radionuclide Endoscopic Imaging System for Hepatocellular Carcinoma Guided Resection on Murine Models

Cerenkov luminescence imaging (CLI) has been proved to be an effective imaging modality for biomedical application. However, the CLI applications were strongly hindered by the low intensity of the luminescence signals. In this study, the FDA approved sodium fluorescein was applied to enhance the CL signals. Furthermore, a novel endoscopic imaging system for Cerenkov radiation energy transfer imaging (CRET) with a clinical laparoscope was developed, which integrated air-liquid dual cooling solution to improve the imaging sensitivity. Hepatocellular carcinoma (HCC) murine models were used for in vivo experiments of CRET tumor detection and guided-resection. The results indicated the feasibility of the proposed CRET methods and the developed endoscopic imaging system. We believed the endoscopic CRET system is promising to increase the sensitivity of early stage tumor detection with great potential in clinical translation.