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[Cav channels and Ca2+ antagonists: recent advances in molecular characteristics and pharmacology].

Voltage-dependent Ca(2+) channels (Ca(v) channels), a big family of Ca(2+) channels, gating of which is regulated in a voltage-dependent manner, play a crucial role as a molecular mechanism linking the extracellular neuronal and humoral signals to the intracellular Ca(2+) signals, with which various types of cells alter their function. Ca(v) channels, therefore, are important targets of drug development for therapeutic agents of cardiovascular and neuronal diseases. By further combined application of novel molecular biological techniques and electrophysiological (patch-clamp) procedures, specific tissue distribution of individual types of Ca(v) channels has been identified in more detail. It is evident now that Ca(v) channels play an important role in regulation of not only physiological and pathophysiological function of excitable cells, but also other non-excitable cells, responsible for immunological response, gene expression, apoptosis, and cell proliferation, providing further potential for development of novel agents for treatment of diverse cell disorders.