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Involvement of Phospholipase C‐related but catalytically inactive protein in regulated exocytosis through the pleckstrin homology and the C2 domains

Phospholipase C‐related but catalytically inactive protein (PRIP) is a scaffolding protein identified in our laboratory. We have recently found that the secretion of various peptide hormones from multiple organs were upregulated in PRIP knock‐out mice, indicating that PRIP regulates the exocytic event common to dense‐core vesicles in a negative manner. In this study, we investigated the molecular mechanism underlying the inhibitory role of PRIP in exocytosis.