{'fraction_non_alphanumeric': 0.016850291639662993, 'fraction_numerical': 0.005184705119896306, 'mean_word_length': 4.826415094339622, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Studies on high and low dose paralysis. Different effect on antibody avidity and on immunocompetent subpopulations of lymphocytes in the mouse

Adult mice were immunologically paralyzed by repeated injections of bovine serum albumin. Partial paralysis was achieved both with a high dose regimen of 10–100 mg and with a low dose regimen of 1–10 μg. The avidity of the antibody produced in response to an immunizing dose of antigen in Freund's complete adjuvant was determined both at the serum level using an antigen‐binding test and at the level of single antibody‐forming cells using inhibition of antibody plaque‐forming cells by free antigens as a test system. The antibody was of relatively low avidity in high dose paralyzed animals, whereas low dose paralysis did not result in a change in the avidity. These data indicate that the B lymphocytes are target cells in high dose paralysis, since a cellular selection was shown to occur. In the low dose paralysis the B lymphocytes seem not to be the immediate target cells, since no cellular selection was demonstrated. Instead, it was shown that the main cellular defect in low dose paralysis was in the T lymphocytes, since carrier‐specific helper cells in an anti‐hapten response were shown to be depleted. Further, studying column purified B and T lymphocytes, it was shown that the cellular site of unresponsiveness in high dose paralysis was both at the B cell and at the T cell level. Low dose paralyzed animals had B cells of normal reactivity, whereas their T cells were paralyzed.