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Towards Non-Invasive Deep Brain Stimulation Using Temporal Interference Method

In this paper, we examine the effectiveness of the temporal interference method through simulations and experiments on phantom models. In this method, the electrodes are placed on the scalp, and no physical damage is done to the subject. In contrast to other non-invasive stimulation methods in which a large part of the brain might be under the influence of the stimulation, the TI method not only has the ability to focus the stimulation at a specific point (with a certain resolution), but also it can move the stimulated spot. In the simulations, we study the current interference pattern inside the human head model, and we use the Hodgkin-Huxley model to map action potentials in our simulations. Moreover, we study the effect of different parameters on how to move the stimulation spot. Our simulation results are verified against experimental measurements on a phantom.