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Development and evaluation of dental film of doxycycline for the treatment of periodontitis

The study has been designed to formulate intrapocket dental film loaded with doxycycline to be used for insertion into the periodontal pockets and evaluate its clinical efficacy. Doxycycline dental films were prepared by the solvent casting technique using polymers such as gelatin was used as film former. Glycerin as plasticizer and glutaraldehyde as cross linking agent were used. The prepared films (F1-F9) were evaluated for various physicochemical parameters employing established pharmaceutical procedures such as surface pH, folding endurance, tensile strength, swelling index, drug content, in-vitro drug release, antibacterial efficacy, stability studies. Experimental parameters of the obtained film exhibited results within the desired limit. Fourier Transform Infrared Spectroscopy and Differential Scanning Calorimetry studies revealed the formulated film to be stable during drug stability and compatible between drugs and excipients. In-vitro dissolution studies showed an initial burst release to achieve an immediate therapeutic level of drug in the periodontal pocket followed by a progressive fall and extended-release of the drug for 12 days.