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Systematic Research and Evaluation Models of Nanomotors for Cancer Combined Therapy.

Limited tumor permeability of therapeutic agents is a great challenge faced by current cancer therapy methods. Herein, a novel near infrared (NIR)-driven nanomotors with autonomous movement, targeted ability, hierarchical porous structure, loaded multi-drugs for cancer chemo/photothermal therapy is designed, prepared and characterized. Further, a method for studying the interaction between nanomotors and cells, along with their tumor permeability mechanism was established, including 2D cellular models, 3D multicellular tumor spheroids model and in vivo  model. Tumor elimination results in vivo  verify that the movement behaviour of the nanomotors can greatly facilitate them to eliminate tumor through multiple therapeutic methods. This work pays attention to setting systematic research and evaluation models and elaborates a strategy to understand the relationship between motion behaviour and cell permeation efficiency of nanomotors in depth and to employ nanomotors to enhance tissue permeability of drugs for effective cancer therapy.