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The state of hemostasis in perimenopause and hormonal replacement therapy

The interruption in the ovarianfunctioning goes along with the disturbances of vascular-trombocyte hemostasis: intravascular trombocyte activation increases, trombocyte micro- and macro-aggregates appear. Cyclic hormonal replacement therapy with Femoston, which contains estradiol and didrogesterone, helps to normalize the trombocytogram. Besides that, the addition of progestagen didrogesterone increases the effect of estradiol on micro circular hemostasia.