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[The effect of lisinopril and amlodipine treatment on left ventricular hypertrophy in hypertensive patients].

UNLABELLED
The aim of the study is an echocardiographic assessment of the influence of a long-term lisinopril treatment in combination with amlodipine in patients with LV hypertrophy.


PATIENTS AND METHODS
In a clinical prospective study that lasted for 12 months, there were 20 subjects included whose blood pressure was under control. Prior to and after 12 months, there was an assessment of treatment efficacy through determining the values of blood pressure, cardiac frequency and echocardiographic examination of the heart, while the safety of administration was assessed based on the laboratorial blood and urine analysis and monitoring of undesirable effects.


RESULTS
Systolic and diastolic blood pressure remained stabile with preserved cardiac frequency. Echocardiographic findings have shown that EF remained intact, and E/A value improved from 0.89 +/- 0.26 to 1.03 +/- 0.61. There were changes in LVMI for 9.3 +/- 1.45 g/m2.


CONCLUSION
Myocardial function remained preserved even after 2.5 years of treatment with amlodipine and lisinopril, in combination, with good tolerance.