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Deleted in oral cancer‐1 (doc‐l), a novel oral tumor suppressor gene

We have identified, isolated, and par‐tially characterized doc‐1, a novel cDNA sequence whose activity is consistent with a suppressor of hamster oral carcinogenesis. Doc‐1 is an evolutionarily conserved gene exhibiting loss of heterozygosity and marked reduction in expression in malignant hamster oral keratinocytes. The full‐length doc‐1 cDNA encodes an 87 amino acid product that shows a significant homology to one of the seven novel genes induced in mouse fibroblasts by TNF‐α. Transfection of the full‐length doc‐1 cDNA into malignant hamster oral keratinocytes alters the behavior of the recipients in terms of morphology, growth rate, and anchorage‐independent growth, suggesting reversion of transformation phenotypes. We propose that doc‐1 is a novel tumor suppressor gene in oral cancer development.—Todd, R., McBride, J., Tsuji, T., Donoff, R. B., Nagai, M., Chou, M. Y., Chiang, T., Wong, D. T. W. Deleted in oral cancer‐1 (doc‐1), a novel oral tumor suppressor gene. FASEB J. 9, 1362‐1370(1995)