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The Effects of Whey Protein Supplementation on Lipid Profile, Serum Leptin and Body Composition during 12 Week Resistance Training in Obese Men

Obesity is one of the major public health problems which can lead to increases of cardiovascular disease due to abnormalities in increases of key markers of blood lipid profile. Whey protein may improve blood lipid profile and reduce body fat that thereby causing the improvement of cardiovascular disease. The aim of this study was to investigate the effects of whey protein supplementation on lipid profile, serum leptin and body composition during an 12-week resistance training program in obese men. Twenty four young obese men (age: 22.7±2.3 years and BMI: 32.1±1.7) volunteered to participate in this study and randomly divided into a whey protein supplementation (WP) group (n=12) and a placebo (PL) group (n=12). Each group was given either whey protein or a placebo in a double blind manner to be taken orally for twelve weeks (1.8g/kg/day). WP and PL groups performed the same weight training program 3 days, each week for 12 weeks. The resistance training consisted of 3 sets of 8 repetitions with 80% of the 1RM for leg extension, leg flexion, squat, bench press, lateral pull down, and triceps pushdown. Statistical analyses were performed using the SPSS software (version 18.0) in the level significance of P< 0.05. Changes from baseline were assessed using the paired sample t-test. In addition, pre-post comparisons between groups were analyzed with independent student’s t-tests. Subjects were tested for lipid blood, serum leptin and body composition variables before and after the 12-week period. The results demonstrated that both groups improved their serum leptin, lipid profile and body composition; however the WP group showed significantly (P< 0.05) greater improved only in TG and fat-free mass when compared to the PL group. It can, therefore, be concluded that implementing of the 12 weeks resistance training combined with ingested of whey protein supplementation aimed at reducing TG and increase fat-free mass can be a good strategy.