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Effects of Chlorothiazide on Glucose Utilization, Glycogen Content, and Lactic Acid Production of Aorta 1

Summary Chlorothiazide in the incubating medium significantly reduces net glucose utilization, glycogen content, and net lactate production of normal dog aorta. When no glucose is present in the incubating medium, these actions of chlorothiazide are not evident. When 1.2 mM lactic acid is present in place of glucose as substrate, net lactic acid production of aorta is decreased by chlorothiazide and glycogen content is unaltered.