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Tuberous Sclerosis Complex; TSC

Even though earlier cases exist, the first detailed description of the disorder was by Désiré-Magloire Bourneville, a French Physician, in 1880 when he described the case of a young girl with severe intractable epilepsy, intellectual disability and a ‘confluent vesiculo-papular eruption on her nose, cheeks and forehead’. Neuropathology showed white, potato-like growths in the brain, referred to by Bourneville as ‘tuberous sclerosis of the cerebral convolutions’. The term tuberous sclerosis complex was introduced by Moolten in 1942 to describe the multi-system nature of the disorder. The abbreviation TSC is used (Kwiatkowski et al., 2010).