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Possible involvement of an acylation mechanism in thalidomide‐induced teratogenesis of the newt (Pleurodeles waltl.)

An acylation reaction of biological polyamines by thalidomide has been postulated to explain the teratogenic activity of this drug ( Fabro et al. 1965 ). In a further study, thalidomide has been reported to acylate polyamines at physiological pH; the teratogenic activity of this drug appears to be linked to its high acylating power towards polyamines ( Audit 1994 ).