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Maltose, A Natural, Efficient and Economical Catalyst for the One-Pot Synthesis of Highly Substituted Dihydropyrrol-2-Ones

Maltose is a natural, economical and very effective catalyst for promotion of the four-component domino reaction between amines, dialkyl acetylenedicarboxylates and formaldehyde to afford substituted dihydropyrrol-2-ones at room temperature. The advantages of this protocol are good yields, short reaction times, low cost, environmentally friendly, simple work-up and lack of need for column chromatography.