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Focus Issue: The ins and outs of ORAI in immune cells

Understanding how ORAI activity is regulated will lead to a better understanding of immune cell function and diseases involving the immune system. This Focus Issue highlights research into cell-specific regulation of store-operated calcium entry through the ORAI/STIM channel complex. Understanding the properties of these channels and how ORAI activity is regulated will lead to a better molecular view of immune cell function and diseases involving the immune system.