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Identification of 7-hydroxyfluphenazine as major metabolite of fluphenazine- 14 C in the dog.

Abstract The major metabolite of fluphenazine- 14 C {4-[1- 14 C- 3 - [2- (trifluoromethyl)phenothiazin - 10 - yl]propyl] - 1 - piperazineethanol dihydrochloride} in dogs and rhesus monkeys is 7-hydroxyfluphenazine. This metabolite was isolated from the feces of dogs by a combination of solvent extraction, column chromatography, and preparative TLC. Mass spectral data and 220-MHz. NMR spectroscopy indicated that the metabolite was hydroxylated on either the C-7 or C-8 position of the phenothiazine ring system. Definitive identification of the metabolite as 7-hydroxyfluphenazine was provided by a comparison of the spectral and chromatographic properties of the metabolite with authentic samples of 7- and 8-hydroxyfluphenazine.