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Expression of granulocyte colony‐stimulating factor receptor on CD10‐positive human B‐cell precursors

We examined the expression of CD10 and G‐CSF receptor (G‐CSFR) on the lymphoid population of mononuclear cells obtained from bone marrow (BM) using two‐colour analysis. In the BM of children with ALL in remission, the CD10+ population was significantly increased (20.6 ± 5.1% compared with that of controls (2.5 ± 0.5%). More than half (61.3 ± 2.9%) of the CD10+ cells coexpressed G‐CSFR, but not CD13. These results indicate G‐CSFR+ B‐cell precursors are markedly increased in BM of ALL in remission, suggesting the probable involvement of G‐CSF in the human early B‐cell ontogeny.