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Effects of extracorporeal photopheresis on serum levels of vitamin D: Preliminary Data from a Pilot Study

Extracorporeal photopheresis (ECP) is a therapy performed on two consecutive days, where plasma and leucocytes are separated extracorporally from the blood of the patient, incubated with the photosensitizer 8-Methoxypsoralen (8-MOP) and subsequently irradiated with UVA (320-400nm) prior to reinfusion into the patient. During ECP patients receive either heparin or acid-citrate-dextrose (ACD) for anticoagulation. Main indications for ECP are cutaneous T-cell lymphomas (CTCL) and Sézary syndrome in particular, acute and chronic graft-versus-host disease (GVHD), systemic sclerosis and rejection after solid organ transplantation. This article is protected by copyright. All rights reserved.