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The Acute Responses of Coronary and Pulmonary Arteries to Natural Steroids

The purpose of this study was to characterize the vascular responses of coronary and pulmonary arteries to naturally occurring androgens and to test the hypothesis that the vascular responses will vary depending on the androgen and anatomical source of the artery. Segments of porcine coronary and pulmonary arteries were dissected, mounted in isolated tissue baths, and administered increasing concentrations of androstenedione (ANDRO), dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT), or testosterone (TES) following constriction with 10 μM prostaglandin F2α. DHT and TES caused a significant relaxation in coronary and pulmonary arteries. The responses to DHT and TES were significantly greater than the responses to ANDRO and DHEA in coronary arteries. In the pulmonary arteries, all androgens caused a significant relaxation at high concentrations. Pulmonary arteries exhibited greater relaxations to DHEA than coronary arteries. The results of these studies indicate that the vascular responses to androgens vary depending on the androgen and anatomical source of the artery.