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A Recent Review on Drug Modification Using 1,2,3-triazole



Motivated by evidence garnered from literature probing the use of triazoles in
drug discovery and development, we reported the utilization of bioisosteric replacement and
molecular hybridization in this review. Bio-isosteric replacement has played a significant
role in modulating rapid and versatile strategy in synthesizing molecules with multifaceted
medicinal properties. Molecular hybridization seeks to conjugate two molecular fragments
with diverse applications under very mild reaction conditions. In this regard, 1,2,3-triazole is
a well-known scaffold with widespread occurrence in medicinal compounds. It is characterized
to have several bioactivities such as anti-microbial, anti-cancer, anti-viral, analgesic, anti-
inflammatory effects. Furthermore, the structural features of 1,2,3-triazoles enable it to
mimic different functional groups justifying its use as bio-isostere for the synthesis of new
molecules of medicinal interest, which we have reported briefly.
