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Metallic compounds (arsenic trioxide and trimethyltin chloride) interact with calcium homeostasis and trigger cell death in “in vitro” systems

While some metals are essential for normal cell function (e.g. zinc, selenium) others could be highly toxic (lead, mercury) and interestingly, some metallic species have dual effects being toxic and healing agents as well: e. g. arsenic trioxide (As2O3) is used to treat cancer but is also a classical carcinogen. While the mechanisms of interaction with living cells is not fully understood, we propose that the modification of intracellular calcium concentration ([Ca2+]i) induced by metallic compounds could be a main reason of cytotoxicity and/or apoptosis.