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S1247 Outcomes of Acute Alcoholic Hepatitis in Patients With Bipolar 1 Disorder

Northwell Health institutions between 01/01/2015 and 12/31/2018.We collected demographics, medical history, vital signs, laboratory data, home medication history and hospital complications and outcomes. Patients with a diagnosis of HRS were manually identified. We performed a bivariate analysis to determine variables associated with the use of NSBB. Results: Most patients were males (N5330, 62.4%) and Whites (N5296, 56%). Alcoholic cirrhosis was the most common identified etiology of cirrhosis (N5233, 44%). The mean CCI (Charlson Comorbidity Index) and MELD scores were 3 (62) and 18 (6 7) respectively. Ascites was the most commonly identified clinical feature of portal hypertension (N5207, 39.1%). NSBBs were used in 39% of patients prior to admission. Infection was identified in 38.4% of patients and SBP occurred in 5.9% of patients. The most common cause of AKI was pre-renal (35.7%). HRS was identified in 9.8% of patient encounters. Patients who used NSBBs at home were less likely to develop HRS and acute tubular necrosis as causes of AKI and were more likely to have pre-renal and cardiorenal AKI. Patients using NSBBs were also less likely to develop SBP and less likely to die. Conclusion: HRS-AKI is associated with high morbidity and mortality. We demonstrate that cirrhotic patients using NSBBs at home are less likely to develop HRS-AKI compared to those who do not use NSBBs. Further prospective studies are needed to evaluate possible expansion of the use of NSBBs in cirrhotic patients for additional indications other than variceal bleeding prophylaxis.