{'fraction_non_alphanumeric': 0.028460543337645538, 'fraction_numerical': 0.00258732212160414, 'mean_word_length': 5.672413793103448, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
In Vitro inhibition of plasmodium falciparum by substances isolated from antimalarial plants.

In the present study, a neosergeolide, isolated from the roots of Jurinea dolomiaea Boiss (Asteracae), the indole alkaloid aspidocarpine, isolated from the bark of Alstonia scholaris (Apocynaceae) and 4-nerolidylcatechol, isolated from the seed of Datura stramonium Linn. (Solinaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. These compounds are good for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and provide support to the traditional use of the plants.