{'fraction_non_alphanumeric': 0.029197080291970802, 'fraction_numerical': 0.004562043795620438, 'mean_word_length': 5.943037974683544, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Effector Cytolotic Funtion but not IFN‐γ Production in Cytotoxic T Cells Triggered by Virus‐Infected Target Cells In vitro

Cytolysis and interferon(IFN)‐γ production are two independent effector functions of activated cytotoxic T (Tc) cells. We have used the Tc‐cell response against the flavivirus, Murray Valley encephalitis virus (MVE), to investigate the requirements for inducing these two functions with regard to antigen‐concentration and CD8 coreceptor involvement. Cognate peptide‐pulsed target cells triggered cytolysis by primary ex vivo MVE‐immune as well as in vitro peptide‐restimulated splenocytes at lower peptide concentrations than IFNγ‐production (100‐fold lower in the case of primary ex vivo effectors). Little difference was observed in CD8 dependency. Importantly, neither of the effector populations were triggered to produce IFN‐γ by virus‐infected target cells, although cytolysis occurred. This result raises the posibility that the levels of presentation of cognate antigen on virus‐infected cells in vivo may be below the threshold required for the IFN‐γ production.