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Genetic Regulation of Allergic Rhinitis

It has been well established that Dermatophagoides farinae (DF) is a major cause of nasal allergy in Japan. There have been many population and family studies describing the relation between IgE mediated allergy and human leukocyte antigen (HLA). These studies suggest that IgE production against a certain antigen such as ragweed, grass pollen, trees, house dust and mites is genetically regulated i1-41. In the present research, which utilized an HLA family and population study, we consider whether nasal allergy to DF is genetically controlled.