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Nicotine cue in rats: effects of central administration of ganglion‐blocking drugs

1 In rats trained to discriminate nicotine from saline, a single intraventricular injection of a small dose of the quaternary ganglion‐blocking drug chlorisondamine blocked the response to nicotine for four weeks. 2 Pentolinium was only weakly active and hexamethonium was inactive as a nicotine antagonist under the conditions used, even in doses that were just below those producing myoclonic jerks. 3 Chlorisondamine had no blocking effect in rats trained to discriminate the non‐nicotinic drugs midazolam or morphine from saline. 4 Intraventricular injections of chlorisondamine have a specific and unusually persistent nicotine‐blocking action, the mechanism of which requires further investigation.