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Effect of phenobarbital and chrysene on theophylline elimination determined by noncompartmental analysis.

The elimination of intravenously administered theophylline was determined in rats after oral pretreatment with phenobarbital and chrysene. The pharmacokinetic parameters of theophylline (Cl, Vdss, MRT) were determined by a noncompartmental method (the moment analysis). The enzyme inducers increased the theophylline clearance from 0.157 l/kg/h in control to 0.232 l/kg/h after chrysene and 0.266 l/kg/h after phenobarbital pretreatment.