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Articles of Significant Interest in This Issue

Lymphatic Type 1 Interferon Responses Control Reovirus Dissemination Type 1 interferon (IFN-1) responses are critical for controlling systemic virus spread. However, little is known about how IFN-1 responses in specific cells and tissues limit viral dissemination. Phillips et al. (e02167-20) found that impairing lymphatic IFN-1 responses by deleting the IFN-a receptor in lymphatic endothelial cells permitted dissemination of an IFN-1-sensitive reovirus mutant. These findings indicate that IFN-1 responses in lymphatics control reovirus spread and further define how reovirus disseminates from mucosal sites of infection.