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Endothelin-1 levels are not influenced by tokishakuyakusan and keishibukuryogan treatment in women.

The effect of Tokishakuyakusan (TS) or Keishibukuryogan (KB) on endothelin-1 (ET-1), a newly identified peptide, in plasma and amniotic fluid from TS- or KB-treated women or normal pregnant women following TS or KB treatment was studied during the menstrual cycle, gestation, delivery and the post-partum period. ET-1 levels during and/or after TS or KB treatment had no significant changes when compared with those in TS- or KB-untreated women. These results suggest that TS or KB has no effects on the ET-1 level during the menstrual cycle, gestation and the post-partum period.