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MEDICAL COMPLIANCE DETERMINANTS FOR TUBERCULOSIS PATIENTS IN PALEMBANG

The majority of countries in the world have tuberculosis, including Indonesia, which has the third rank in the world. This is due to a large number of sufferers who were not successfully cured. One of the factors that influence the recovery of tuberculosis patients is adherence to taking anti-tuberculosis drugs for a certain period of time. Non-adherence to treatment can exacerbate the risk of disease because it can lead to MDR (Multi Drugs Resistant) tuberculosis. This study aims to analyze the determinants of tuberculosis treatment compliance in the city of Palembang. This study used an analytical study with a semi-quantitative approach, with a cross-sectional design. Sampling was carried out by proportional random sampling at 39 Puskesmas Kota Palembang, a total of 243 samples that met the inclusion and exclusion criteria. Data collection was carried out by means of interviews using a questionnaire. Data were analyzed using the chi-square test and multiple logistic regression. Obtained adherence to treatment of tuberculosis patients by 42.8%. There was a significant relationship between perceived benefits (p = 0.000; OR = 3.556), family support (p = 0.000; OR = 3.512), support from health workers (p = 0.001; OR = 2.712), knowledge (p = 0.018; OR = 2,027) with adherence to treatment of tuberculosis patients. The level of compliance with tuberculosis patients in Palembang City is still low, namely 42.8%. The most important determinant of adherence is perceived benefit with a 3.556 times greater opportunity after controlling for other variables.


Introduction
WHO has declared a global emergency for tuberculosis because tuberculosis is out of control in most countries in the world. This is due to the large number of patients who have not been successfully cured, especially those who are infectious (smear-positive). 1 For tuberculosis, Indonesia Third ranks in the world. In Indonesia, it is estimated that every year 150 thousand people die caused by tuberculosiss. 2 The dropout rate of TB patients in Indonesia is 4.1% of 294,732 TB cases, which is consist of 12.084 people. 3 Based on the annual report on the results of treatment of TB patients in South Sumatra Province in 2012, the dropout rate for TB patients was 4.14% (218 people), while for the city of Palembang the dropout rate for TB patients in 2012 was 4.019% (52 people). The dropout rate can be reduced if there is an attention from the patient's environment to remind them about medication which calls Drug Administration Supervisor (PMO).
A large number of TB cases caused by the high dropout rate, and the low number of PMOs pose a risk for non-compliance and exacerbate the risk of disease for TB patients, named the occurrence of MDR (Multi Drugs resistant) TB. MDR TB treatment was more difficult than the TB treatment which is still sensitive. MDR TB can be cured although it takes a longer time, namely 18-24 months.
Tuberculosis patient recovery is affected by adherence to taking anti-tuberculosis drugs for a certain period of time. Tuberculosis treatment must be carried out by the patient for a period of six months. Treatment with a long time and the consumption of drugs that must be done every day allows patients to dropout or not adhere to treatment. 4 Therefore it is necessary to know how adherence to treatment of tuberculosis patients in Palembang City is to reduce the risk of MDR TB which requires longer time and more expensive medical costs so that researchers are interested in knowing the determinants of tuberculosis patient treatment compliance in Palembang. This study aims to analyze the determinants of tuberculosis treatment compliance in the city of Palembang.

Method
This research is an analytical study with a semi-quantitative approach. This research is an analytic observational study using a cross-sectional research method, namely studying the correlation between individual characteristics factors, previous behavior, specific behavior, and interpersonal behavior with treatment compliance of pulmonary TB patients in Palembang.
The population in this study were all pulmonary TB patients who were registered in the TB treatment register in Palembang totaling 1,247 people. The sample consisted of 243 patients with pulmonary tuberculosis who were registered in the TB treatment register at the Public Health Center of Palembang, which was obtained from the formula for calculating the sample size of the hypothesis test for two population proportions (Lameshow, 1977) who had met the inclusion and exclusion criteria. Sampling was done by proportional random sampling. 5 Primary data collection was obtained by interviewing using a questionnaire. 6 The dependent variable of this research is compliance with tuberculosis patient treatment and the independent variables of this study are individual characteristics (age, sex, marital status, occupation, education), previous behavior (knowledge, attitudes, history/complaints of pulmonary tuberculosis, perceptions of health status), specific behaviors (perceived self-efficacy, perceived barriers, perceived benefits, perceived threats/dangers), and interpersonal support (family support, advice for treatment, support from health workers, presence of PMO, and the influence of the social environment).
Analysis of the data in this study used univariate, bivariate analysis with chi-square and multiple logistic regression using the Backward LR method to see the determinants that most influence on compliance with tuberculosis patients treatment, then interpret the results of the analysis and create an equation model. Because the research design used was cross-sectional, the size of the association used in this study was POR (Prevalence Odds Ratio) with the same formula as OR. With the complete OR, P and CI values, variables that have OR at 95% CI and p-value <0.25 can be considered to be included in the multivariate model (multivariate analysis), which is used is Unconditional Logistic Regression Analysis.

Results
The results of this study obtained 42.8% compliance with tuberculosis patients treated in Palembang. The complete distribution of treatment adherence is shown in table 1 below: The univariate analysis carried out on 18 variables can be seen in Table 2 below: The results of the bivariate analysis using the Chi-Square test to determine the determinants of tuberculosis patient treatment compliance in full are presented in table 3 below: In the multivariate analysis, variables were taken which in the bivariate analysis obtained pvalue <0.25. Table 3 shows the results of the Chi-Square analysis where there are variables that get a p-value <0.25, including variables of employment, knowledge, perceived threats, perceived benefits, family support, and support from health workers. These six variables will be included in the multivariate analysis. The Complete is presented in table 4 below: There was a significant relationship between knowledge and adherence to taking tuberculosis medication at BKPM Pati, meaning that patients with less knowledge have the opportunity to not adhere to taking the medication by 3.857 times. 8 The results of other studies in accordance on 70 respondents at BKPM Surakarta showed a positive relationship between the level of knowledge about a disease and pulmonary tuberculosis treatment and the level of adherence to treatment programs (p = 0.001). 9 Knowledge and motivation of tuberculosis (TB) patients will have an impact on compliance in implementing treatment programs 10  From the results of the analysis of the relationship between a specific behavior and compliance with tuberculosis patients in Palembang, it was found that the perceived usefulness and self-efficacy variables had a statistical test value of p-value <α (0.05), this means that there is a relationship between perceived benefits and perceptions of self-efficacy with adherence seeking treatment for tuberculosis patients in Palembang. Furthermore, the self-efficacy and level of education have significant influence toward the behavior of self-examination, therefore it can be reference for health practitioner and researcher to promote health behavior among family of patient with Tuberculosis. 13 In the perceived benefit variable, the OR value obtained is 2.768, so it can be concluded that pulmonary TB patients who feel the benefit of pulmonary TB disease treatment will be 3 times more obedient than pulmonary TB patients who do not feel any benefit from pulmonary TB disease treatment at 95% CI (1,609-4,760).
This study was in line with research that there is a relationship between perceived benefits of treatment compliance for tuberculosis patients with a P-value of 0.019 and OR = 5.814. Patients will find it easier to carry out and undergo complete treatment if the patient feels the benefits of treatment, especially a complete recovery from the disease they suffer. If the patient feels that the treatment being carried out is not useful, the patient tends to not comply with the treatment rules so that there will be non-adherence to the treatment. In conclusion, Patients' perceptions of TB have reflected indicators of perceived resistance and self-efficacy significantly affect treatment compliance. 2 14 In the perception of self-efficacy, the OR value is 2.243, so it can be concluded that tuberculosis patients who have a good perception of self-efficacy towards tuberculosis treatment will be 2 times more obedient than tuberculosis patients who do not have a good self-efficacy perception of tuberculosis treatment at 95% CI (1,253-4,014). Perception of self-efficacy, namely the perception of being able to help itself to recover from a disease. The belief in healing can be grown from the intention of each tuberculosis patient to get well. Health promotion and education need to be provided in order to provide understanding, knowledge, and explanation about tuberculosis so that there will be changes in attitudes and behavior of tuberculosis patients in undergoing treatment.
The results of the analysis of the relationship between interpersonal influence and compliance with treatment of tuberculosis patients in Palembang, it was found that the variable family support and health worker support had a statistical test value of p-value <α (0.05) and OR 2,985 treatment compliance. That's why supporting patients during medication program of tuberculosis is needed to improve their adherence medication during multidrug therapy. 15 Family support covered informational support, instrumental support, emotional support, and appraisal support needed tuberculosis patients, including support of nutrition fulfillment. 16 Furthermore, aspects of social support which include family support, peer group support and support from health workers have an important role and become a driving factor for TB patients to adhere to the treatment regimen. For further research, the development of interventions to improve adherence to TB patients needs to consider these social aspects. 17 The results of research that support this research, showed that there was a significant relationship between family support and compliance with tuberculosis medication at BKPM Patidan, that family support that lacked the opportunity to not comply with medication was 5,800 times. The results on 134 respondents at the Eradication of Lung Disease (BP4) or Karangtembok Hospital Surabaya showed that there was a relationship between family support and increasing compliance with drinking OAT in tuberculosis patients (p = 0.001). 8 18 This result is inversely proportional to the other research in Palembang City, it was found that there was no effect between family support and treatment compliance. 6 The difference in the results obtained may be a change in behavior and the patient's desire to get family support while undergoing a treatment period. A patient who gets support from his family will be more enthusiastic in undergoing treatment, especially if the family can pay more attention and remind him to take medication for 6 months so that it can be concluded that pulmonary TB patients who receive support from health workers in the treatment of pulmonary TB disease are 3 times more compliant than pulmonary TB patients who did not get the support of health workers in the treatment of pulmonary TB disease at 95% CI (1,681-5,084).
Family support, socioeconomic, physician and nurse support, availability to access health services, social stigma, psychological stress, and knowledge were significant factors of the successful treatment of tuberculosis. 19 Another results showed there was a significant relationship between family support (emotional, material, and informational support) with medical compliance of patients with pulmonary tuberculosis. 20 It is suggested for health professionals to always promote the importance of family support for the successful of medical treatment among tuberculosis patients. 21 Furthermore, support provided by health workers can be in the form of morale, for example giving encouragement to complete treatment and playing an active role inhome visits if the patient does not take medication so that health workers who have a high work ethic are needed to overcome this tuberculosis disease. 6,22 It is necessary to conduct a home visit program by health personnel for patients who are not compliant to check phlegm and conduct further research for health service factors. 23 Beside that, strong social support within a patient's family, community, or health care context can help counteract structural and personal barriers to adherence by influencing motivation or knowledge and beliefs about TB. However, lack of support or knowledge about TB and its treatment in a patient's family, community, or health care context, as well as real or perceived stigmatization of the sick, can hinder adherence. 24 The results proved that peer group support could affect the medication time adherence on pulmonary tuberculosis patients. It can be concluded that peer group support can be used as an optional intervention to increase the obedience of pulmonary tuberculosis treatment in patients. 25

Conclusion
The description of adherence to treatment of tuberculosis patients in Palembang was only 42.8%. There is a relationship between perceived benefits, family support, support from health workers, knowledge with compliance with tuberculosis patient treatment in Palembang City. The most important determinant of adherence is perceived benefit with a 3.556 times greater opportunity after controlling for other variables

Acknowledgment
The researcher would like to thanks for our supervisor and team of this thesis Research Examination Commission, which has taken the time to attend the exam and provide input to perfect the thesis written by the researcher, also for All public health center has facilitated providing patient data and addresses of TB patients, making it easier to conduct interviews with patients' homes.

Funding
There is no funding for this research, and the funds used are the author's personal funds.