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A bovine muscle extract with anti-cirrhotic and anti-inflammatory properties in the rat.

An extract from bovine muscle, prepared by proteolytic digestion, inhibits the development of CC1(4)-induced liver cirrhosis when administered either subcutaneously or orally to the rat. It has a significant effect on survival time, liver and body weight, and gross and microscopic features, collagen, water, protein and triglyceride content of liver. It also accelerates the regression of CC1(4)-induced cirrhosis. Most of these effects were also achieved with a heat-stable or lipid fraction of the extract. The heat-stable fraction also shows anti-inflammatory activity in carrageenan- and egg white-induced edemas and in cotton pellet granuloma.