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Recombinant human relaxin modulates angiotensin II-induced cardiac fibrosis

AIM:To observe the influence of recombinant human relaxin(rhRLX)on cardiac fibroblast(CF)functions under angiotensin II(Ang II).METHODS:We cultured neonatal rat CFs in Ang II(10-6 mmol/L)conditions in the absence or presence of rhRLX(100 μg/L).The cell growth of CF rate was determined by MTT colorimetry.Levels of procollagen type I C-terminal peptide(PICP)and procollagen type III amino terminal peptide(PIIINP)were detected by ELISA.RESULTS:rhRLX significantly inhibited the proliferation of cultured CF induced by Ang Ⅱ(P0.01).AngII accelerated the production of PICP in CFs.rhRLX blocked collagen synthesis induced by Ang II.CONCLUSION:rhRLX ameliorates cardiac fibrosis induced by Ang II.