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Inefficacy of Sildenafil treatment of idiopathic pulmonary hypertension

There were studied effects of phosphodiesterase inhibitor Sildenafil on clinical and functional status in young patient with severe primary pulmonary hypertension. Sildenafil was applicated in dose of 50-100 mg daily for 12 weeks, clinical and functional status were estimated initial and after every month of treatment. The retrospective analysis do not detected any positive dynamics in all estimated parameters, this phenomena may be explained by individual patient refractivity on this group of medicine.