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Clinical immunology of immunodeficiency diseases symptoms and signs of primary immunodeficiencies.

This article gives a general overview of the signs and symptoms observed in primary immunodeficiencies (PID). These diseases, although rare, are useful in the understanding of the specific functions and properties of the immune system. Emphasis has not been placed on the biological and laboratory features since the principal goal is to describe the clinical approaches for a correct diagnosis in this group of diseases. Schematic indications of therapy are given only in single diseases, when necessary. The report and the classification are organized according to the more recent recommendations of a Special WHO-Committee for Primary Immunodeficiencies.