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ANTIBODY RESPONSE IN CROSSES BETWEEN HIGH OR LOW IMMUNE RESPONDER AND INBRED STRAINS OF MICE

The global dominance of ‘high’ or ‘low’ genes operating in high (H) or low (L) selected immune responder lines of mice has been studied in F1 hybrids between these lines and various inbred strains of mice. Two antigens were used: cyte, SE) and the alum‐precipitated bovine serum albumin (BSA‐A1). In (H × L)F1 hybrids the H response is partially dominant for the two antigens during the primary response. This is the most frequent feature observed in hybrids between H or L and inbred strains. But some exceptions indicate that the quantitative immune response genes of H and L mice aar not always equivalent to those of inbred strains. In (L x AKR)F1 hybrids immunized with SE, there is a dominance of the L response. Concerning BSA‐A1, an initial, short lasting dominance of L response is observed in (L × C57B1/6)F1 and (L × C3H)F1 hybrids. The lack of secondary response to BSA‐A1, characteristic of the L line, is completely recessive in all hybrids. The question is open whether primary and secondary responses have the same genetic regulation. No overdominance of high or low responsiveness is observed. This means that the main genes regulating the quantitative antibody response have been accumulated in the selected lines.