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PP.33.14: ADIPOKINES A LINK BETWEEN OBESITY AND HYPERTENSION

Objective: Obesity is associated with hypertension (HTN), but precise mechanisms still need to be investigated. Adipokines may be the link, as some were associated with the pathways of end-organ damage in cardiovascular diseases. The aim of the present study was to compare the profile of serum adipokines and their association with blood pressure levels (BP) in obese and normal body weight hypertensive patients and healthy controls. Design and method: We examined 30 hypertensive obese patients (BMI more than 30 kg/m2), age and sex-matched 18 normal-weight hypertensive patients and 15 healthy controls. Both systolic and diastolic “office” BP levels were higher in obese group compared to normal-weight hypertensive subjects. Ambulatory blood pressure monitoring (ABPM, SpaceLabs 90207), applanation tonometry (SphygmoCor, Artcor Medical) with calculation of central aortic pressure was performed in all subjects. Adipokines (adiponectin, leptin, resistin, visfatin, adipsin) levels were determined by using Bio Plex Pro Human assays. Results: Adiponectin level was significantly higher in healthy controls and normal-weight hypertensive patients compared to obese subjects (4.3 ± 1.7, 4.0 ± 2.3 and 3.3 ± 1.9 pg/ml, respectively; ANOVA, p = 0.049), interestingly there were no difference in other adipokines between groups. However, in hypertensive obese patients some adipokines were associated with diastolic BP levels - adipsin with “office” diastolic BP (r = 0.427, p = 0.048), resistin grades with “office” (r = 0.488, p = 0.025) and central (r = 0.456, p = 0.038) diastolic BP and also visfatin levels with central diastolic BP (r = 0.451, p = 0.035). Conclusions: Obese hypertensive patients are characterized by decreased adiponectin levels and both peripheral and central diastolic BP levels appear to be associated with some adipokines (adipsin, resistin and visfatin).