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A Multi-crosslinking Nanocapsule-based Serial-Stimuli-Responsive Leakage Free Drug Delivery System in Vitro.

As some stimuli utilized in conventional drug delivery systems can also be found in normal cells, it is inevitable that encapsulated drugs escape from carriers into normal cells. Based on mutual interactions among proteins, polyphenol compounds, and metal ions, we developed a serial-stimuli-responsive drug delivery system. With multi-crosslinking structure, nanocapsules can maintain the integrity of the framework, even a certain amount of stimuli present, and eventually reach tumor cells to initiate apoptosis, and protect normal cells from being damaged. Meanwhile, the fluorescence of DOX will be quenched when encapsulated in nanocapsules. Owing to this property, the released DOX from nanocapsules will be real-time monitored through the recovery of fluorescence. These versatile nanocapsules have exhibited great potentials to treat cancer.