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Fate of demineralized freeze-dried bone allografts in human intrabony defects.

Demineralized freeze-dried bone (DFDBA) is the most widely used allograft in periodontics. Little information exists, however, on the fate of DFDBA matrix or on the effects of residual particles within grafted defects. The purpose of this study was to histologically examine the fate of DFDBA used for regeneration in intrabony defects. A secondary objective was to compare the amount of new attachment apparatus formation, including component tissues, in relation to the presence or absence of residual graft material. Histologic data were obtained from earlier studies in which intrabony defects grafted with DFDBA were removed at 6 months en bloc and submitted for histologic examination. Histologic sections (1,120) from 12 patients with 32 grafted defects revealed that 72% of the grafted defects exhibited residual DFDBA particles. When present, DFDBA appeared amalgamated within the new viable bone. Data from 5 patients with 14 grafted sites permitted a within-subject comparison of the amount of regeneration in relation to the presence or absence of residual graft material. Defects harboring residual graft particles exhibited significantly greater amounts of new attachment apparatus formation (1.72 mm vs. 0.20 mm), including new bone (2.33 mm vs. 0.23 mm), cementum (1.74 mm vs. 0.23 mm), and associated periodontal ligament than sites without evidence of graft matrix (P < or = 0.05). No apparent differences were seen in the nature of the new attachment apparatus or component tissues, other than in amount of formation. Inflammation and graft containment appear to be important factors influencing the fate of DFDBA and the regenerative response.