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Adoptive transfer of early and late delayed-type hypersensitivity reactions mediated by human T cells.

Human T cells activated by antigen in vitro mediated both the 2-hour and 24-hour phases of delayed-type hypersensitivity (DTH) when transferred into the mouse footpad. The passively transferred human DTH was similar to murine DTH by kinetics, vasoactive amine dependence, and histologic criteria. These results offer a functional assay for determining whether human T cells are activated by viral or tumor antigens.