{'fraction_non_alphanumeric': 0.05131467345207803, 'fraction_numerical': 0.04410517387616624, 'mean_word_length': 5.033248081841432, 'pattern_counts': {'":': 0, '<': 2, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
PP.21.14: EFFECTIVENESS OF FIXED-DOSE COMBINATION OF BISOPROLOL AND AMLODIPINE IN PATIENTS WITH ARTERIAL HYPERTENSION AND CORONARY HEART DISEASE

Objective: Assess the effect of a fixed combination of beta-blocker bisoprolol and dihydropyridine calcium antagonist amlodipine on circadian blood pressure profile, pulse wave velocity and central aortic pressure in patients with hypertension and coronary heart disease (CHD). Design and method: Open, prospective and randomized study included 61 patients with uncontrolled hypertension and CHD. Patients were randomized into 2 groups: Group 1 (n = 30) was treated with an angiotensin-converting enzyme inhibitor (ACE) Ramipril 10 mg/day, a fixed combination of Bisoprolol and Amlodipine in individual doses. Treatment of the 2 (control) group (n = 31) necessarily included the free combination of an ACE inhibitor, beta-blocker and dihydropyridine calcium antagonist. Initially and after 12 weeks of treatment ambulatory blood pressure monitoring using complex BPLab Vasotens («Petr Telegin», Russia) was performed. The main indicators of circadian blood pressure profile (BP), pulse wave velocity in the aorta (PWVao, m/s), augmentation index (Alx,%), systolic and diastolic aortic pressure were evaluated. Results: After 12 weeks of therapy, the target level of BP was recorded 96.7% in the 1 group and 87.1% in the 2 group of patients. The use of both types of therapy associated with a significant decrease in daytime and nighttime systolic and diastolic BP(p < 0.01). However the variability of blood pressure, the magnitude and speed of morning rise in BP was significantly decreased only when using a fixed combination of Bisoprolol and Amlodipine (p < 0,01). In group 1 PWVao had reduced with 11,2 ± 0,27 to 9,44 ± 0,21m / s (p = 0.0001), Alx from -7,53 ± 6,66 to -25,12 ± 3, 72 % (p = 0.008) in systolic aortic pressure from 130,9 ± 2,43 to 113,3 ± 1,3 mmHg (p = 0.0001), diastolic aortic pressure from 88,6 ± 2,45 to 74,97 ± 1,03 (p = 0,0001). In the control group, these indicators have improved insignificantly. Conclusions: In patients with hypertension and CHD of the fixed combination of amlodipine and bisoprolol provided significant antihypertensive and vasoprotective effects are more pronounced in comparison with the free combination of beta-blockers and dihydropyridine calcium antagonist.