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Spotlight on the March 26 Issue

This study used resting-state functional connectivity MRI (rs-fcMRI) to investigate within- and between-network connectivity among 5 functional brain networks in 58 HIV-infected participants and 53 HIV-uninfected controls. HIV-infected individuals showed decreases in rs-fcMRI intranetwork and internetwork correlations, leading to a baseline decrease in brain function similar to but independent of deterioration seen with aging.

See p. 1186; Editorial, p. 1178

The authors examined the effect of education on FDG-PET brain metabolism in 52 cognitively healthy subjects with preclinical Alzheimer disease (AD). Higher education was associated with lower FDG-PET activity in preclinical AD for a given level of cognitive performance, suggesting …