{'fraction_non_alphanumeric': 0.03933253873659118, 'fraction_numerical': 0.0017878426698450535, 'mean_word_length': 4.97508896797153, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Metabolic and cardiovascular effects of selective intracoronary injections of contrast media.

Metabolic and cardiovascular actions of water soluble radiopaque substances (WSRO) were studied after selective intracoronary injections. Meglumines (MG) tested were old Renografin (ORG), new Renografin (NRG), and Conray (CR). Na+ salts studied were Angioconray (AC), Hypaque (H), and Urokon (U). Thorotrast and 6% Nacl were included for comparison. All MG and Na+ salts decreased fractional extraction of lactate. Increased glycolysis is suggested. The MG ORG and CR decreased lactic acid uptake (LAU) but NRG (ORG with its NaCl content reduced to 25%) left LAU unchanged. Na+ salts, AC, and H also decreased LAU but U, which has a toxic basic molecule, increased it. The MG ORG and CR as well as the Na+ salt U increased the lactate/pyruvate ratio. These indicate increased glycolysis. Free fatty acid uptake (FFAU) was increased by MG ORG and CR but depressed by NRG. FFAU was decreased by Na+ salts AC and H but increased by U. Cardiac output was decreased by the MG salts but increased by Na+ salts; coronary flow was increased by all the WSRO tested. Systemic blood pressure and left ventricular end diastolic pressures were unchanged. EKG exhibited inverted T waves, S-T segment deviations, extra-systoles and increased sinus bradycardia in descending order of frequency. S-T segment changes and extrasystoles suggest ischemia. Intracoronary artery injections of some opaque media produce major changes in cardiac metabolism, reflected in lactic acid and free fatty acid uptakes. These changes are accompanied by venous lactate and L/P ratio modifications suggesting ischemia.