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Inhibition of Adenylate Cyclase of Regeneration-Competent Cells of Nervous Tissue: a Novel Approach for the Treatment of Alcoholic Encephalopathy

Researching new pharmacological targets and developing highly effective drugs to treat ethanol-induced encephalopathy is an urgent task of neuroscience and pharmacology. The work aimed to study the neuroprotective and neuroregenerative effects of adenylate cyclase (AC) inhibitors in modeling alcoholic encephalopathy in experimental animals. The morphofunctional repair of the brain and the functioning of progenitors (neural stem cells (NSC) and neuronal-committed progenitors (NCP)) and neuroglial cells (astrocytes, oligodendrocytes, microglial cells) of the subventricular zone of the cerebral hemispheres (SVZ) have been investigated. A significant correction of brain morphological changes, disorders of exploratory behavior, and conditioned reflex activity in laboratory animals under the influence of the AС inhibitor were revealed. Increased proliferation of both types of progenitor cells and accelerated differentiation of the NSC were observed when AC inhibitors were administered to mice with neurodegeneration. Improved neurotrophin secretion by astrocytes and microglia was also identified. The findings show the promise of developing a novel approach to treating alcohol-induced encephalopathy with AC inhibitors.