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Rate of change of sickle allele frequency may be influenced by total fertility rate: a sesquicentenary reflection on human micro‐evolution

This article considers the impact of evolutionary forces on the prevalence of sickle cell anemia (SS disease) the most common genetic disease among persons of West African descent living in the Caribbean. It describes the examination of population prevalence and neonatal screening data for Jamaica from different periods and the inability to find any significant decline in sickle (S) allele frequency over the past 22-47 years. It states that their observations on S allele frequency indicate that the combination of improved patient care and population-wide changes in reproductive behavior can have important effects on the genetic makeup of populations.