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Association between genome‐wide DNA methylation pattern and response to trastuzumab in HER2‐positive breast cancer patients

The administration of trastuzumab has led to significant improvement in survival of HER2‐positive breast cancer patients in the adjuvant and metastatic settings. Trastuzumab resistance, however, has been increasingly recognized as a major obstacle. Recent evidence suggests that epigenetic mechanisms might be associated with acquired resistance to cancer therapies. Aim of this study was to explore the association between genome‐wide DNA methylation pattern in breast cancer tissue and the response to trastuzumab.