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Dysregulation of intracellular Ca2+ in lymphocytes and neutrophils in type 2 diabetic patients (1072.11)

Background: Patients with T2D are immune‐compromised, making them more susceptible to infections and long term complications than non‐diabetic individuals. Neutrophils and lymphocytes play key roles in host‐immune responses to infections, and their phagocytic and chemotatic activities are reduced in diabetes. To date, the underlying causes for impairment in neutrophils and lymphocytes functions in T2D remain poorly defined. Dysregulation of intracellular Ca2+ cycling is a common phenotype in many diabetic cells. This study investigated if intracellular Ca2+ cycling is also defective in neutrophils and lymphocytes isolated from individuals with T2D.