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FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF CINNARIZINE BY SUPER DISINTEGRANTS ADDITION METHOD

The aim of the present work is to study the Preformulation parameters for Cinnarizine orodipersible tablet. The objective of pre-formulation study is to generate information useful to the formulator in developing stable and bioavailable dosage form. Administration of conventional tablets of Cinnarizine has been reported to exhibit fluctuations in plasma drug levels, either in manifestation of side effects or reduction in drug concentration at the receptor sites. Conventional Cinnarizine tablets available in market are not suitable where quick onset of action is required. Besides, the conventional tablets also show poor patient compliance particularly by the geriatric and pediatric patients who experience difficulty in swallowing, and by those who are bed ridden or who are traveling and do not have an easy access of water. Usage of excipients like low-substituted hydroxypropyl cellulose, crospovidone helps for the faster disintegration and faster release of the drug from the dosage form. The Preformulation studies were carried out in terms of test for identification (physical appearance, melting point, and UV spectrophotometer), solubility profile, and determination of partition coefficient and quantitative estimation of drug. All the observations and results showed that the Cinnarizine could serve as suitable candidate for fast dissolving tablet that may improve the bioavailability.