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Analysis of interleukin‐13 receptor α2 expression in human pediatric brain tumors

Compared with normal brain tissue cells, human malignant glioma cells express higher levels of interleukin‐13 receptor (IL‐13R). However, whether this receptor is expressed in situ has not been carefully examined. With IL‐13R–targeted cytotoxin (IL13‐PE38QQR, comprising IL‐13 and a mutated form of Pseudomonas exotoxin [PE]) being tested in three Phase I/II clinical trials for the treatment of adult human glioma, and with pediatric studies being planned, the authors set out to analyze pediatric brain tumor tissue specimens for the expression of IL‐13R.