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Since the time of Edward Jenner, vaccines have been scientifically acknowledged to be one of the most cost-effective means for human beings to survive various infectious diseases causing enormous morbidity and mortality. In Korea, there had been earlier literature regarding the concept of vaccination even before Suk-Young Ji introduced the practice of smallpox vaccination in late 19th century. During the past over 20 years, the naturally occurring smallpox had been declared eradicated worldwide, and many infectious diseases such as diphtheria, tetanus, pertussis, poliomyelitis, measles, mumps, rubella, hepatitis A, hepatitis B, and yellow fever are called vaccine preventable diseases.