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Depletion of Caveolin‐1 in Lung Vasculature and Increase in Caveolin‐1 Positive Circulating Extracellular Vesicles as Early Biomarkers of Endothelial Injury

Endothelial cell activation and dysfunction are hallmark features of Acute Lung Injury and Acute Respiratory Distress Syndrome (ALI/ARDS). Caveolin‐1 (Cav‐1) is highly expressed in pulmonary microvascular endothelial cells (PMVECs) and plays a key role in maintaining vascular homeostasis. The aim of this study was to determine whether the lung inflammatory response to endotoxin promotes PMVEC Cav‐1 depletion and appearance of Cav‐1 positive circulating extracellular vesicles (Cav‐1+ EVs) and whether this contributes to ALI.