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[Study of intraglandular heterogeneity of hormonal dependency in rat prostate].

STUDY OF INTRAGLANDULAR HETEROGENEITY OF HORMONAL DEPENDENCY IN RAT PROSTATE Norio Hayashi, Yoshiki Sugimura, Masaki Sakurai and Juichi Kawamura Department of Urology, Mie University School of Medicine (Director: Prof. J. Kawamura) Morphological and biochemical aspects of androgen dependency of rat prostate gland were reevaluated by our original microdissection technique. As shown in the previous paper, rat prostate is morphogenetically clasiffied into 5 lobes (i.e., ventral, lateral type 1, lateral type 2, dorsal lobes and coagulating gland). In this study, androgen deprivation-induced regression and androgen-induced regeneration of those prostatic lobes were individually investigated by various hormonal treatment. Regression of the prostatic gland was studied by castration or 17a-estradiol treatment and regeneration was studied by testosterone propionate (TP) treatment. Marked difference in the degree and rapidity of morphological and biochemical change were observed among prostatic lobes. Coagulating gland and the ventral lobe were more sensitive to sex hormones than the other lobes with regard to the gross ductal branching morphology, histology, wet weight and DNA contents. The ventral lobe is most androgen dependent, the lateral type 1 lobe has the least androgen dependency in their morphological and functional maintenance. This study clearly shows that the prostatic gland is not a homogenenous organ in its morphology and cellular activities. We consider that this intraglandular heterogeneity is one of the most important biological characters of the prostatic gland and may directly relate to the pathogenesis of such localized abnormal growth as prostatic hyperplasia and cancer of the prostatic gland.