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The effect of intravenous infusion of lipids on the exercise-induced serum growth hormone rise in normals and juvenile diabetics.

Juvenile diabetics and normal subjects were studied during different exercise loads, and juvenile diabetics were studied with half-hourly blood sampling during day-time. The growth hormone response to exercise in normals, the growth hormone hyperresponse to exercise in juvenile diabetics, and the growth hormone hypersecretion during day-time in juvenile diabetics were not diminished when the exercise-induced fall in free fatty acids in normals and diabetics and the fluctuations in the day-time free fatty acid level in diabetics were prevented by intravenous infusion of Intralipid and heparin, resulting in serum-free fatty acid levels 3-7 times higher than normal. A feedback mechanism between free fatty acids and growth hormone could not be demonstrated.