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Acrosclerosis Associated with Vibration: an Electron Microscopic Study

A case of typical vibration‐induced acrosclerosis was studied with the electron microscope. In addition to increased collagenization of the dermis, vascular wall and perivascular spaces, a severe vacuolization and an increased number of lysosomes in the vascular endothelial cells were observed. In many peripheral nerves, axonal degeneration, demyelination and an extensive collagenization of peri‐ and endoneurium were observed. These changes appeared to be the organic basis for sclerosis and neuropathies of this condition.