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Hemophagocytic syndrome associated with high‐dose lamotrigine

© 2007 Japan Pediatric Society Hemophagocytic syndrome (HPS) is associated with viral, bacterial, and fungal infections, lymphomas or other malignant diseases, autoimmune diseases, and metabolic diseases. Thus, the diseases underlying this syndrome vary widely. 1 – 4 Two forms of HPS have been characterized: familial erythrophagocytic lymphohistiocytosis and infection-associated HPS. Because HPS is not always infection induced, with many cases associated with a variety of malignant neoplasms, or some drugs such as phenytoin, a more accurate description for this acquired form of the syndrome is reactive HPS. 5