{'fraction_non_alphanumeric': 0.038334434897554524, 'fraction_numerical': 0.03965631196298744, 'mean_word_length': 4.2387543252595155, 'pattern_counts': {'":': 0, '<': 3, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
[Ulinastatin's early effects on kidney's expression of HSP70 and IL-6 after mechanical injury of kidney].

OBJECTIVE
To investigate the significance of ulinastatin's effects on kidney's expression of IL-6, HSP70 after mechanical injury.


METHODS
Sixity-six adult female Wistar rats were randomly divided into three groups: 6 in the group of control, 30 in the group of trauma, 30 in the group injected ulinastatin after trauma. The model of trauma rats was made with free-fall bio-impactor striking the spinal column and ribs of rats. To detect the IL-6 and HSP70 expression of each group's renal tissue at 1 h, 6 h, 12 h, 24 h and 36 h after trauma with tissue chip and immunohistochemical stain.


RESULTS
IL-6 and HSP70 expression of renal tissue was low with group of control. Compared with group of control, the expression of IL-6 strengthened at 1 h, 6 h, 12 h, 24 h after trauma (P < 0.05),the expression of HSP70 with group of trauma strengthened at 6 h after trauma (P < 0. 05). The expression of IL-6 with group injected ulinastatin after trauma were more lower than group of trauma, the expression of HSP70 at 1 h, 24 h, 36 h after trauma was higher than group of trauma especially at 1 h (P< 0.05).


CONCLUSION
Ulinastatin can reduce the risk of renal injury in early times after trauma especially at 1 h. The protective effects of ulinastatin may be associated with the restrict the expression of IL-6, up-regulation of HSP70 expression, and change the proportion between IL-6 and HSP70 expression.