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Role of Kv 1.5 Channels in Regulation of Myocardial Oxygen Balance

The major “job” of the coronary circulation is to deliver oxygen and nutrients to the myocardium in a manner to match the myocardial demands under various conditions. Oxygen extraction in the coronary circulation is 70-80 % under resting conditions, which leaves very little reserve for further extraction. Because extraction is near maximum, to increase oxygen delivery further extraction is not a viable option. Previously, we found that Kv 1.5 channels appeared to couple cardiac work to myocardial blood flow. Specifically, we found reduced levels of flow per unit of cardiac work in mice null for the redox sensing Kv1.5 channel (Kv1.5-/-) compared to wild types (Wt). Based on these observations, we hypothesized that myocardial oxygen tension (pO2) at different cardiac workloads is lower in Kv 1.5-/- mice than in wild-type mice. For pO2 measurements, oxygen-sensing paramagnetic probes (LiNc-BuO:PDMS chip) were implanted into the left ventricular wall. After 2 weeks of implantation, pO2 was measured by using ...