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von Willebrand Factor: A Loyal Ally of Venous Thrombosis in Obesity.

In the current issue of ATVB, Michels et al 1 demonstrated an important role of VWF (von Willebrand factor) in deep vein thrombosis (DVT) in the setting of obesity. Using a mouse model of inferior vena cava stenosis, the authors report high plasma levels of VWF and Factor VIII, and larger thrombi in mice on high-fat diet than in mice on standard diet. Genetic ablation of VWF or its inhibition by either a conventional antibody or a nanobody (targeting specifically A1 domain) reduced venous thrombosis.