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Reproductive aging is an evolutionarily programmed strategy that no longer provides adaptive value.

Demographic, historical, and clinical studies provide evidence that fertility in women declines with age, even after controlling for other causes of infertility (1). Because women increasingly delay marriage and attempts at childbearing within marriage, age-related infertility has become a major clinical problem. Decreased fertility becomes significant in many women by their late 30s or early 40s, even though they continue to have ovulatory menstrual cycles.