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Alternative RNA Splicing: New Approaches for Molecular Marker Discovery in Cancer

In cancer, several alterations driving cell transformation including: imbalances DNA, changes in gene expression as well as protein diversity. The transcriptional regulation is finely driving and controlled by a large number of molecules, including: SR proteins, hnRNPS, RNA, DNA, histones methylation, among others. However, in cancer the regu lation is altered. It is little kwon regulations causing alternative splicing in healthy and human diseases. The alternative splicing plays an important role in the generation of diversity of transcripts its proteins resulting. The aberrant transcripts variants expressed in can- cer have shown a great potential as biomarkers or therapeutics targets. In this manuscript, we showed the basic in alternative splicing and a simple method using available data for detection alternative transcripts expressed in the tree most common human cancer.