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Skeleton, blood vessels and viscera: overlooked targets in fetuses of small species during the external examination for teratogenicity assessment.

Due to the translucency of the skin and underlying soft tissues, the external examination of near-term mouse fetuses can be extended to parts of the skeletal, visceral and vascular systems which are not taken into account in the protocols of teratogenicity tests. The importance of such visualization for improving the accuracy of such tests is discussed.