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SELECTED ASPECTS OF PENICILLIN ALLERGY

SUMMARY.— Skin tests for immediate hypersensitivity with penicillin derivatives and haemagglutination tests for penicilloyl‐specific IgG and IgM antibodies are useful in the prevention, diagnosis and management of clinical adverse reactions mediated by IgE antibodies. In rare instances, the skin tests themselves may cause clinical adverse reactions. Under suitable conditions, hyposensitization or temporary loss of skin sensitivity can be successfully brought about, even in individuals with a high degree of immediate hypersensitivity.