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Study of local anesthetics. Part 46: Correlations between anesthetic activity and physico-chemical parameters of some alkoxy substituted esters of phenylcarbamic acids.

The partition in water-octanol and water-carbon tetrachloride systems and electronic spectra of three series of esters of phenylcarbamic acid and its m- and p-alkoxy derivatives were measured. The surface local anesthetic activity of these compounds as well as the infiltration anesthetic activity of some of them were correlated with combinations of partition coefficients, spectral parameters and sigma-coefficients.