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[Nipecotic acid, a competitive inhibitor of the net uptake of 3H-GABA by rat brain synaptosomes].

The kinetics of inhibitory effect of nipecotic acid on two different types of 3H-GABA uptake (apparent uptake by intake and net-uptake by predepolarized synaptosomes) was studied. Nipecotic acid was shown to inhibit the net-uptake of 3H-GABA by competitive route. It is concluded that analysis of inhibitory, action of a substance and of its kinetics should by performed with due regard for at least two components; homoexchange of GABA which might reach 50-60% of total radioactivity taken up and the net-uptake of the neurotransmitter.