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Gentamicin in the Treatment of Salmonella Infections

Changes in the ecology of Salmonella organisms impose the use of highly specific chemotherapeutic agents both in animals and in attempts to combat Salmonella typhi in man. An examination of the inhibition achieved by the use of a number of antibiotics against strains isolated from 52 hospitalized patients in our clinic, over the past three years, has shown the majority of strains to be sensitive to gentamicin (78%), followed by nalidixic acid, nitrofurantoin, chloramphenicol (44%) and other chemotherapeutic agents, including the combination of sulphamethoxazole and trimethoprim (28%) and ampicillin (11%).