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Transient receptor potential channel promiscuity frustrates constellation pharmacology

Sensory neurons from the trigeminal and dorsal root ganglia (DRG) have nerve endings in the skin and mucosa, where they detect environmental stimuli and convey this information to the central nervous system. Several members of the transient receptor potential (TRP) superfamily of ion channels act as prime molecular sensors for thermal and chemical stimuli in these sensory neurons. However, it is incompletely understood how TRP channel expression and modulation affect the stimulus sensitivities of distinct neuronal subtypes.