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Synthesis of Thin‐Layered Molybdenum Disulfide‐Based Polyaniline Nanointerfaces for Enhanced Direct Electrochemical DNA Detection

The low electronic conductivity limits the application of molybdenum disulfide (MoS2) in electrochemical sensing field, let alone the label‐free and self‐signal amplification DNA sensing. Aiming at this problem, a novel polyaniline‐molybdenum disulfide (PANI‐MoS2) nanocomposite through a facile oxidation polymerization aniline monomer on the thin‐layer MoS2 matrix is prepared, which is preobtained via a simple ultrasonic exfoliation method. It is generally appreciated that conducting polymers, e.g., polyaniline (PANI), can work as a direct transducer based on themselves‐signal without any label or indicator. Moreover, MoS2 not only serves as an excellent conductive skeleton provided a high electrolytic accessible surface area for redox‐active PANI, but also supports a direct path for electron transfer. Therefore, the hybrid of PANI and MoS2 exhibits superior electrochemical performance to pure PANI and MoS2, and can be considered as a superior candidate for direct and label‐free electrochemical DNA sensing. A series of experiments are performed to investigate the effect of synthetic conditions (component, dosage of MoS2, and reaction time) on probe DNA (pDNA) immobilization and hybridization adopting the PANI self‐signal as the measure signal. The results show that the dosage of MoS2 has a more influence on pDNA immobilization and hybridization.