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sleBioRepo: a curated database of gene expression levels, in systematic lupus erythematosus

Lupus, systematic lupus erythematosus (SLE), is an autoimmune disease in which the human immune system attacks the body itself. However, manually curated database for messenger RNA (mRNA) gene expression levels and SLE association studies have yet to be established. Here, we constructed a user-friendly database, “sleBioRepo,” equipped with a graphical web interface for simple browsing, or for searching differences of gene expression levels between control and case group. Datasets in our database cover 32 gene expression omnibus (GEO) series, consisting 2,042 samples of diverse body tissues (e.g., blood, skin, and kidney). Also, we provide graphical demographics and differentially expressed genes of user-selected samples and genes for improving knowledge of the biological complexity of this pathology. We asserted that our database will be a comprehensive resource for mRNA biomarker studies, as well as for prioritizing mRNAs for a functional validation in SLE with likely extension to other diseases.