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In vivo Antioxidant Activityof Ethanolic Extract of Aerial parts of Albizia procera roxb ( benth . ) against Paracetamol induced Liver Toxicity on Wistar Rats

To evaluate the in-vivo antioxidant activity of aerial parts of ethanolic extract of Albizia procera against paracetamol induced toxicity in rats. Paracetamol treated rats shows significantly reduced the levels of tissue enzymatic antioxidant and non enzymatic antioxidant. The level of TBARS are elevated in paracetamol treated rats (groupII) when compared with control group of rats. The ethanolic extract of Albizia procera in paracetamol treated rats were found lowered concentration of TBARS when compared with paracetamol treated rats. Paracetamol induces the oxidative stress in cell by producing reactive oxygen species. After administration of ethanolic extract of Albizia procera in paracetamol treated rats showed significant increase in the levels of antioxidant enzyme such as superoxide dismutase (SOD), catalase (CAT) and non enzymatic antioxidant glutathione (GSH) when compared with paracetamol induced rats (groupII). Based on the results, it was concluded that the ethanolic extract of Albizia procera have significant in-vivo antioxidant activity and can be used to protect tissue from oxidative stress.