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[The effect of captopril on cerebral blood flow in hypertensive rats before and after cerebral ischemia].

Acute experiments were conducted on narcotized hypertensive rats (vasorenal hypertension) to study the effect of captopril (5 mg/kg, intraperitoneal injection) on arterial pressure and cerebral blood flow and its autoregulation before and after transitory (10-12 min) ischemia of the brain (bilateral occlusion of the carotid arteries). Captopril normalized the arterial pressure, but changes in the cerebral blood flow proved to be insufficiently stable, particularly in the postischemic period. Normalization of autoregulation of the cerebral blood flow was noted. In captopril treatment the survival rate among rats with ischemia of the brain increased.