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Segregation of lipids near acetylcholine-receptor channels imaged by cryo-EM

A single-particle helical reconstruction from cryo-EM images reveals a segregated distribution of lipids around acetylcholine-receptor channels in the outer leaflet of the bilayer. The existence of a cholesterol-rich microdomain next to the receptor suggests how this lipid ensures a productive conformational change when acetylcholine binds, triggering the channel to open.