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Synthesis and Characterisation of Aqueous Haemoglobin-based Microcapsules Coated by Genipin-Cross-Linked Albumin

Bovine serum albumin (BSA)-coated haemoglobin (Hb)-microcapsules prepared by co-precipitation of Hb and MnCO3 may present an alternative type of artificial blood substitute. Preparation and storage in Ringer’s solution provides a medium for synthesis as well as for application to the circulatory system later on. The capsules come along with a mean diameter of approximately 0.6 μm and a mean volume of 1.13 · 10−19 L, thus an average human red blood cell with a volume of 9 · 10−14 L is about 800,000 times bigger. Hb-microcapsules prepared by the applied method are fully regenerable by ascorbic acid and maintain oxygen affinity because oxygen is able to pass the BSA wall of the capsules and thereby binding to the ferrous iron of the haemoglobin entity. Therefore, these microcapsules present a suitable type of potential artificial haemoglobin-based oxygen carrier (HbOC).