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Multifactorial Interventions Before Laser Photocoagulation Improve Outcome of Diabetic Macular Edema

Diabetic macular edema is often associated with multiple comorbid systemic conditions (1). In a pilot study (2), multifactorial interventions in clinically significant macular edema (CSME) led to a decrease in retinal thickness. However, the effect of these interventions, before laser photocoagulation, on the outcome of diabetic macular edema has not been studied.

In a prospective study, 125 patients (180 eyes; 72 men and 53 women; median age 55 years [range 38–72]) completed a minimum follow-up of 1 year (median 1.8 years [range 1.0–2.7]). All underwent multifactorial interventions, including initiation of insulin therapy ( n = 47), newer oral hypoglycemic agents ( n = …