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Onion peel extracts have hepatoprotective effects and decrease blood levels of LDL cholesterol in liver injuried rats

Onion Peel Extracts (OPE) are known as rich sources of quercetin derivatives. Quercetin has been reported to have antioxidant and anti‐inflammatory properties. The objective of this study was to evaluate hepatoprotective effects of dietary OPE supplementation on liver injuries induced by carbon tetrachloride (CCl4) in rats. OPE were extracted with ethanol, concentrated, and freeze dried to a powder. Thirty two Sprague‐Dawley rats were divided into control group, CCl4 group, 0.15% OPE with CCl4 group, and 3% OPE with CCl4 group. Experimental diets were provided for four weeks. We measured blood lipid levels and enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Part of the liver was separated and lipid peroxide level(TBARS) was measured. CCl4 cause a marked increase in the activities of serum ALT and ALP levels and the levels of TBARS in the liver. Supplementation of OPE significantly attenuated liver toxic effects of CCl4, and decreased the activities of ALT, and ALP. OPE offered a dose‐dependent hepatoprotective effects and the blood levels of LDL cholesterol were also decreased by supplementation of the OPE. These findings indicate that OPE have hepatoprotective effects in CCl4‐indced liver injuries by reducing lipid peroxidation and enhancing antioxidant properties. Hepatoprotective effects of OPE improve blood cholesterol profiles.