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Adenovirus in the omics era – a multipronged strategy

Human adenoviruses (HAdVs) are common pathogens associated with a wide variety of respiratory, ocular, and gastrointestinal diseases. To achieve its effective lytic mode of replication, HAdVs have to reprogram host‐cell gene expression and fine‐tune viral gene expression in a temporal manner. In two decades, omics revolution has advanced our knowledge about the HAdV and host‐cell interplay at the RNA and protein levels. This review summarizes the current knowledge from large‐scale datasets on how HAdV infections adjust coding and noncoding RNA expression, as well as how they reprogram host‐cell proteome during the lytic course of infection.