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The early neurologic signs and symptoms of HIV infection

Since the earliest days of the HIV pandemic, the acute and subacute phases of infection have been characterized by some extent of CNS involvement,1 most prominently aseptic meningitis.2 These early reports were hampered by the variable availability of tests for the presence of antibodies to HIV (ELISA in 1985, Western blot in 1987) and the lack of quantitative assays for viral RNA until the early 2000s.