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A sample-in result-out lab-on-a-chip device: from prototype to mass fabrication

In this paper we demonstrate the development of an integrated lab-on-a-chip system for the point-of-care diagnostics of Coeliac disease. A two-step approach is used, using two different microfluidic chips with identical footprint and functional landscape, one for the analysis of the genetic predisposition using human leukocyte antigen typing, the second for a serology assay. Emphasis has been put on using a seamless technology path from prototyping to final device manufacture in order to allow an upscaling of production volumes without a chance in production technology. Therefore, injection molding has been extensively used, however using standard formats allowing the use of family tools in order to reduce the cost of manufacturing.