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Relation between Donor Transaminase and Recipient Hepatitis Non‐A, Non‐B in Sweden

Abstract. The relation between donor alanine aminotransferase (ALT) and recipient post‐transfusion hepatitis (PTH) non‐A, non‐B was studied in patients tested before and 6 and 12 weeks after transfusion. The minimum ALT criterion for PTH was 105 IU/1 (> 2.5 times the upper normal of 42 IU/1). In 8.8% of donors, ALT was > 42 IU/1, and in 2.3% ALT was > 63 IU/1, i.e., 1.5 times elevated. PTH non‐A, non‐B occurred in 14 of 742 recipients. The PTH incidence increased when donor ALT was above 63 IU/1 (1.5 vs. 5.6%; p < 0.05). However, if the confounding factor of volume variations was compensated for, elevated donor ALT and PTH were only statistically linked among recipients < 70 years (p < 0.02; Mantel‐Haenszel test).