{'fraction_non_alphanumeric': 0.02860705640724712, 'fraction_numerical': 0.014816988190420304, 'mean_word_length': 5.3591417910447765, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Esophageal metastasis of breast cancer during endocrine therapy for pleural dissemination 21 years after breast surgery: a case report

Background The esophageal metastasis of breast cancer is rare. Moreover, it is extremely unusual for patients to experience the symptoms of esophageal metastasis during their lifetimes. We present a case of dysphagia caused by esophageal metastasis after a long interval following a primary mastectomy. Case presentation A 77-year-old woman with a history of heterochronous bilateral breast cancer and under treatment for pleural dissemination recurrence originating from right breast cancer complained of dysphagia. At the age of 56, she had undergone a right radical mastectomy for right breast cancer. The histopathological findings revealed invasive ductal carcinoma, pT3N1M0, which was estrogen receptor (ER)- and progesterone receptor (PgR)-positive. At the age of 73, she underwent a second operation, a left modified radical mastectomy. The histopathological examination revealed invasive ductal carcinoma, pT1N0M0, which was negative for ER, PgR, and human epidermal growth factor receptor 2 (HER2). Four years after completion of adjuvant therapy for the left breast cancer, pleural effusion on her left side was observed and histopathological examination of a sample revealed pleural dissemination resulting from the right breast cancer. After initiation of therapy for recurrence, she developed dysphagia and, therefore, underwent an upper gastrointestinal tract endoscopic examination. The examination revealed whole circumferential stenosis and a band unstained by Lugol’s solution located 30 cm from her incisors. Examination of a biopsy specimen revealed a subepithelial luminal structure and dysplastic cells. Immunostaining was positive for CK7 and negative for CK20; furthermore, the sample was ER and PgR-positive. Considering the pathological findings, the patient was diagnosed with esophageal metastasis of her right breast cancer. Conclusions Metastatic lesions in the esophagus are often located in the submucosa; therefore, they may not be definitively diagnosed by histopathological examination of mucosal biopsy specimens. Esophageal metastasis originating from breast cancer often occurs as a part of multiple organ metastases; however, esophageal metastasis is usually not considered a prognostic factor for patients. Therefore, treatment should be determined according to the severity of the other metastatic sites and the degree of esophageal stenosis.


Background
Breast cancer has a prolonged course and has the potential for systemic metastasis. The common sites of breast cancer metastasis include the lymph nodes, liver, bone, lung, and brain, while esophageal metastasis is rare. Case reports of esophageal metastasis from breast cancer are mainly autopsied cases; therefore, patients with symptoms of esophageal metastasis who are diagnosed while alive are extremely unusual. We present a case of dysphagia caused by esophageal metastasis 21 years after the patient had undergone a primary mastectomy.

Case presentation
A 77-year-old woman with a history of heterochronous bilateral breast cancer complained of dysphagia. At the age of 56, she had undergone a right radical mastectomy for right breast cancer. Histopathological examination revealed invasive ductal carcinoma, pT3N1M0 that was estrogen receptor (ER)-and progesterone receptor (PgR)-positive. The human epidermal growth factor receptor 2 (HER2) status was not assessed at that time. She had taken doxifluridine (5-DFUR) for 2 years and then tamoxifen for 5 years as adjuvant therapy. At the age of 73, a screening mammogram revealed a left breast mass and she was diagnosed with left breast cancer after examination. She underwent a second operation, a left modified radical mastectomy. The histopathological findings revealed a 12-mm apocrine carcinoma of the left breast without lymph node metastasis. The cancer was negative for the expression of ER, PgR, and HER2. The patient was administrated six courses of a combination therapy of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) as adjuvant therapy. After a 4-year absence, a regularly scheduled check-up revealed pleural effusion on her left side that increased in size at a 6-month re-examination. Pleuorocentesis performed to harvest the pleural effusion revealed pleural dissemination. Considering that the cell block obtained from the pleural effusion was ER-positive, she was diagnosed with a recurrence of her right breast cancer. She had a history of compressed fracture and was under treatment for osteoporosis; therefore, the patient was treated not with an aromatase inhibitor but with high-dose toremifene citrate. After initiation of therapy, she developed dysphagia. An upper gastrointestinal tract endoscopic examination revealed a whole circumferential stenosis 30 cm from her incisors and a 2-cm band unstained by Lugol's solution. At this point, the lumen was occluded by a toremifene citrate tablet. Transoral endoscopy was unsuccessful; therefore, the tablet was pushed back into the stomach by small diameter endoscopy (Fig. 1). Hematoxylin-eosin staining of the biopsy specimen revealed a subepithelial luminal structure and dysplastic cells covered with normal squamous epithelia, and immunostaining was positive for CK7 and negative for CK20 (Fig. 2). An esophageal submucosal tumor originating in breast cancer was suspected based on the pathological findings. The specimen was positive for ER and PgR; therefore, the patient received a definitive diagnosis of esophageal metastasis of her right breast cancer 21 years after surgery. Esophagography revealed midesophageal stenosis more than 5 cm in length, with a minimal luminal diameter of around 3 mm (Fig. 3 a). Computed tomography (CT) also revealed wall thickening of the mid-esophagus, but there was no swelling of the lymph node around the mediastinal level (Fig. 4a). After 3 months of high-dose toremifene therapy, the pleural effusion had disappeared on CT (Fig. 4b), and her dysphagia was improved. Esophagography showed improvement of the esophageal lumen stenosis (Fig. 3b). High-dose toremifene was effective for 8 months, but the patient complained of dysphagia again and was

Discussion
In an autopsy study of 1020 patients by Yanagawa et al. [1], primary lesions of esophageal metastasis were observed primarily in the stomach (308 cases, 30.2%); the lungs, trachea, and bronchus (291 cases, 28.5%); and hematopoietic bone marrow (87 cases, 8.5%); in contrast, only 22 cases (2.2%) originated from the breast. In another autopsy case report, Abrams et al. [2] reported a prevalence of esophageal metastasis from breast cancer of 4.2%. However, Borst and Ingold reported esophageal metastasis in only 0.4% of 2246 breast cancer patients followed for 18 years [3]. Asch et al. [4] also reported that 5.9% of autopsies of patients with breast cancer had esophageal metastasis but that only 0.59% had complained of dysphagia. In light of these reports, metastasis to the esophagus in breast cancer patient is relatively rare and the prevalence of symptoms differs from the frequency at which it is identified during autopsy.
According to the literature, 27 cases of esophageal metastasis from breast cancer including our case have been reported in the last 20 years [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. A summary of these cases is shown in Table 1. The median age of diagnosis of esophageal metastasis was 68 years and most of the patients complained of dysphagia as a primary symptom (data not shown). Hormone receptor and HER2 expression were described in eight cases, all of which expressed hormone receptors. Esophageal metastases developed most commonly in the middle thoracic esophagus and a b c d e f extended up to 10 cm in length. The median time from the operation for breast cancer to the onset of esophageal metastasis was 11 years; interestingly, intervals more than 20 years were reported in four cases including ours [12,13,20]. The initial biopsy failed to definitively diagnose esophageal metastasis in almost half of the cases. This is because metastatic lesions are often located in the submucosa, and mucosal biopsy generally does not provide a sufficient amount of sample for definitive diagnosis. We did not use a special method for biopsy; however, we could collect a sufficient amount of sample, including submucosal tissue, for diagnosis of esophageal metastasis in this case. According to Matsumoto et al. [21], mediastinoscopy or surgery may be required for a definitive diagnosis; they also suggested endoscopic ultrasound-guided fine-needle biopsy as an alternative diagnostic tool. The mechanism for how breast cancer spreads to the esophagus is unclear. There are two possible pathways for metastasis from the breast to the esophagus: lymphogenous metastasis of the paraesophageal lymph nodes via the parasternal lymph and mediastinum, and hematogenous metastasis in case of the absence of mediastinal lymph node swelling [23]. Indeed, 8 of 27 cases in the literature did not have any metastasis other than that of the esophagus, while 9 of 27 cases synchronously had loco-lesional recurrence, 9 of 27 cases had distant metastasis, and other metastasis sites were not reported in six of the 27 cases (Table 1). In our case, mediastinal lymph node swelling was not observed. However carcinomatous pleurisy originated from breast cancer occurs as a result of lymphangitis-type and subpleural lymphatic progress [24]. The patient had pleural dissemination; therefore, lymphogenous rather than hematogenous metastasis was suspected.
The treatment for esophageal metastasis also varies ( Table 1). Twenty-one of 27 cases were administrated systemic therapy including chemotherapy and endocrine therapy; 14 of 27 cases received local treatment, including surgery and radiation therapy; and 11 of 27 cases were treated endoscopically. Goldberg et al. [25] reported that esophageal metastasis originating from breast cancer often occurred as a part of multiple-organ metastases, resulting in poor prognosis. In this case, pleural dissemination was diagnosed initially and systemic treatment was started; then, dysphagia was observed that led to the diagnosis of esophageal metastasis. On retrospective examination of a CT scan taken at the time she was diagnosed with pleural dissemination, we observed wall thickening of the mid-esophagus. Thus, we inferred that this esophageal metastasis was a part of organ metastasis. Systemic therapy is important for the management of multiple organ metastases. However, patients with only esophageal metastasis survived for more than 5 years after metastasis onset [20,22]. Sato et al. [18] suggested that the esophagus could be a site of primary recurrence; thus, the possibility of esophageal metastasis should be considered during follow-up examinations to maintain a disease-free status. These cases may also result from lymphogenous metastases; thus, local control by surgery or radiation therapy may be effective.
Esophageal metastasis causes dysphagia and can seriously decrease patient quality of life but is usually not considered a prognostic factor for patients. Therefore, the treatment should be decided according to the severity of other metastatic sites and on the degree of the esophageal stenosis. Atkins et al. [26] reported that radiotherapy only or combined with chemotherapy were efficacious treatments for dysphagia caused by esophageal metastatic lesions. Other reports showed that endocrine monotherapy remarkably improved symptoms [14]. Surgical resection is usually not selected because systemic therapy takes priority for metastatic breast cancer. In the literature, three cases survived more than 20 months after surgical resection to esophageal metastasis. For cases with esophageal metastasis without other severe visceral metastases, surgical resection may provide good local control. However, surgical resection requires careful consideration because of its severe adverse events. Endoscopic dilation is not considered a standard therapy due to the risk of perforation. Sugauchi et al. [7] reported a very high rate of perforation; however, the recent use of self-expanding metallic stents may result in good outcomes.
In our case, endocrine therapy was started initially for pleural dissemination, and then, she was diagnosed with esophageal metastasis with dysphagia. After the patient developed resistance to the initial endocrine therapy, radiation therapy combined with secondary endocrine therapy was started, and it has been effective for more than 15 months, suggesting the importance of local control for esophageal metastasis.

Conclusions
The prevalence of the symptoms of esophageal metastasis originating in breast cancer differs from its prevalence in autopsies; therefore, it is likely that there is a comparatively large number of breast cancer patients with latent esophageal metastasis. Metastatic lesions in the esophagus are often located in the submucosa; therefore, they may not be diagnosed definitively by single histopathological examination of mucosal biopsy specimens. Esophageal metastasis originating from breast cancer often occurs as a part of multiple organ metastases, and radiotherapy only or combined with chemotherapy are efficacious treatments for dysphagia. However, esophageal metastasis is not usually considered a prognostic factor. Therefore, treatment should be decided according to the severity of the other metastatic sites and the degree of esophageal stenosis.