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[Is prone positioning of not-mechanically ventilated patients with moderate hypoxaemia due to covid-19 advantageous?]

In mechanically ventilated patients with ARDS, prone positioning has demonstrated improvement, not only in oxygenation but also in survival. Whether early prone positioning of patients with mild hypoxemia and ARDS due to covid-19 improves outcome in terms of survival and prevention of the need for invasive ventilation was recently investigated in a RCT. Physiological reasoning would suggest a potential benefit. But no advantages of prone positioning were found in the study population of 250 patients. However, compliance to the intervention was very low in the intervention group making it practically impossible to assess the effects of the intervention. Therefore, clinicians should still rely on physiological reasoning and individual effects of prone positioning in deemed suitable patients.