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LIFE SPACE ACTIVITY IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Background and Aims: Physical inactivity is an important feature for COPD patients. To evaluate physical activity (PA), two major methods, that is, direct method and questionnaire are applicable. We evaluated physical activity in patients with COPD cross-sectionally and longitudinally using LSA (Life space assessment) score, which is one of questionnaires for PA. The aim of this study is to evaluate the factors which affect physical activity. Methods: We enrolled 162 stable subjects from Kyoto University Hospital outpatient clinic. They took interview, pulmonary function test, and questionnaires such as mMRC, CAT, LSA, and PHQ9 (depression assessment). After one year, we performed same assessment again, to evaluate longitudinal changes of each index. Results: Finally, 152 patients (male : female = 143 : 9, median age 71, median %FEV1 63.9) were analyzed cross-sectionally. LSA significantly correlated with age, %DLCO, mMRC, CAT, PHQ9 and weakly with %FRC (P = 0.06). And age, PHQ9 and CAT were significant determinants in multivariate analysis. In longitudinal analysis, LSA changes correlated with %FRC changes only. Conclusion: Patients’ physical activity is affected by symptoms and mental status, on the other hand, hyperinflation could be most important functional factor on changes of physical activity. In this point of view, deflation by pharmacological and/or non-pharmacological approach is important for maintain physical activity in COPD patients.