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The effect of thermal treatment of immunoglobulin E as measured with competitive and noncompetitive assays: is circulating immunoglobulin E serologically heterogeneous?

Using two-double antibody assays (DA) and a noncompetitive assay (PRIST), we measured in 20 atopic and 10 normal sera the total IgE before and after its heating at 56 degrees C for 30-120 min. After heating the sera or radiolabeled IgE, DA detects a reproducible increase in total IgE associated with a large intersubject variability of the inhibition curves. On the contrary, heated total IgE measured with PRIST decreases and there is no intersubject difference in the observed change. In conclusion, DA assays of IgE reveal a heterogeneous response to heating which might be related to interindividual differences in the tertiary/quaternary structure of the D sigma 2 domain of Fc sigma.