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[Effect of in vivo aging on the growth of rat fibroblastic cells from cutaneous explants].

The migration of fibroblastic cells from explants and the fibroblastic proliferation were two important parameters of healing. They were studied from animal explants of different ages and correlated with a qualitative and quantitative histologic analysis of the cutaneous tissue. These results confirm the decrease of the migration-proliferation capacity of the fibroblasts from cutaneous explants with age. This decrease was associated during maturity with a decrease of cell density in the dermis. It was no longer correlated during the passage from the adult to the senescent state. We must therefore admit an evolution in cell differentiation.