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Selective and Sensitive Electro Chemical Determination of D-Cycloserine Using Graphene Paste Sensor and its Application Studies

Abstract Graphene have attracted considerable attention in synthesis and electrochemical applications. In the present study, graphene paste electrode (GPE) was used to study electrochemical behavior of D-Cycloserine (DCS) using cyclic (CV), staircase (SCV) and square wave (SWV) voltammetric techniques. The electrochemical sensor showed excellent enhancement and adsorptive ability towards the electrooxidation of DCS. The electro-oxidation mechanism was proposed. Experimental parameters, such as the surface area of electrode, scan rate and pH of solution were optimized. Under the optimized conditions, the oxidation peak current was proportional to DCS concentration in the range between 1.0×10-8 - 1.5×10-7 M for SCV and 1.0×10-8 - 1.1×10-7 M for SWV and the detection limit was 2.80 nM for SCV and 3.70 nM for SWV. The proposed SCV method was observed to be simple, fast and inexpensive and hence, could be readily adopted for quality control in pharmaceutical products.