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Posttransfusion Non‐A, Non‐B Hepatitis after Cardiac Surgery: A Prospective Study

Abstract. In a prospective study of 50 recipients of HBsAg‐negative blood who had undergone cardiac surgery, 4 (8%) developed acute non‐A, non‐B hepatitis. The patients who developed hepatitis had received significantly more units of blood or blood products than the patients who had no hepatitis. The incubation period of the disease was 4–13 weeks, 3 patients were asymptomatic with peak alaminotransferase (ALT) levels of 320–497 U/l and 1 patient was jaundiced with a peak ALT of 3,400 U/l. 1 of the patients had high ALT levels after 21 weeks of observation, while 3 patients recovered after 7–10 weeks. It is concluded that non‐A, non‐B posttransfusion hepatitis in Israel is a medical problem similar to that in the USA and that the clinical picture of the disease varies from a mild asymptomatic to a symtomatic and protracted course.