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Endocannabinoids mediate the glucocorticoid‐induced inhibition of excitatory synaptic transmission to dorsal raphe serotonin neurons

•  The modulation of the serotonin system by glucocorticoids plays a central role in the regulation of stress responses. However, the mechanisms by which glucocorticoids regulate the excitability of dorsal raphe serotonin neurons remain unknown. •  In this study, we show that glucocorticoids rapidly inhibit glutamatergic synaptic transmission to serotonin neurons by reducing glutamate release. •  The rapid inhibition of glutamate release is not signalled by classical intracellular glucocorticoid receptors, but rather by putative membrane‐located G‐protein‐coupled receptors. •  Activation of the membrane‐located G‐protein‐coupled receptors increases endocannabinoid signalling, which in turn mediates the inhibition of glutamatergic transmission in the dorsal raphe. •  In the dorsal raphe, glucocorticoids increase endocannabinoid tone by inhibiting cyclooxygenase‐2.