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Design and analysis of microneedles structures for transdermal drug delivery

In this paper we present the designs and analysis of different shapes of microneedles. We determined which one is the most appropriate for transdermal drug delivery purposes. The 450 μm microneedles length as long as their 70 μm outer diameter and 26 μm inner diameter measures allowed us to reduce the loss factor at the moment of the insertion into the skin; also to be undetectable to the human nerve system reaching only up to the epidermis. Analysis and simulation of microneedles were performed using ANSYS Finite Element Analysis (FEA) tool, to determine the shape that reduces the most all stresses caused during the skin piercing process. Microneedles simulations results were conclusive indicating that the stresses due to the applied loads were under the yield strength of the set of hardened materials, such as Nickel (Ni), Silicon Carbide (SiC) and Silica (SiO2).