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Antipyrine metabolism in female Lewis and Dark Agouti strains of rats, which are extensive and poor metabolizers of debrisoquine, respectively.

The metabolism of antipyrine (AP) was investigated in female rats of the Dark Agouti (DA) and Lewis (L) strains, which have been proposed as models for human poor and extensive metabolizers of debrisoquine (DB), respectively. Following i.p. injection of 50 mg/kg of AP, the rate of production of 4-hydroxy-antipyrine in 24-hr urine was increased significantly in the L strain. The results suggested that different cytochrome P-450 isozymes were responsible for hydroxylation of AP and DB and showed interphenotype differences between the two strains.