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Reviews in NeuroVirology: An introduction

This issue highlights the intersection of neurovirology and emerging infectious diseases. The enclosed reviews illustrate several points: first, that many emerging infections, even thosewhere the respiratory system is the primary site for clinical manifestations, e.g., SARS (seeYuen) orNipah (seeBellini), can cause severe central and peripheral nervous system disease. Second, infections of wildlife and domestic animals pose threats to global human health. More than 75%of emerging infectious diseases, includingAIDS, Nipah (Bellini), West Nile encephalitis (see Bernard and Briese), new variant Creutzfeldt Jakob disease (see Chesebro), influenza, and SARS are zoonoses (diseases caused by microbes that jump from animals to humans). The number of zoonotic microbes that jump to human hosts is increasing with close contact between wildlife, domestic animal and human populations due to political instability, deforestation, urbanization, international travel and trade (see Mackenzie). We have only defined a small portion of the microbial world and know little about the microbial flora of domestic animals let alone those in