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Histomorphologic changes in lymph nodes with lymphotropic immunostimulation in experiment

The research deals with the study of
histomorphologic changes in the lymph nodes of rats arising
from the lymphotropic and intramuscular administration
of acidic peptidoglycan. The authors investigated histologic
changes and applied the morphometric method including
the determination of the average size of the lymph nodes,
the size of the germinal zones, the density of the lymph
nodules. It is stated that the restructuring of the lymph nodes
during lymphotropic administration occurs at different
times in comparison with its intramuscular administration.
The lymphotropic method provides a relatively earlier and
prolonged onset of an immunostimulating effect. This made
it possible to conclude that the method of administering
immunomodulators should differentiate depending on the
phase and form of the disease progression.