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Technetium-99m phosphate bone imaging: a method for assessing bone graft healing.

A gamma scanning method has been developed for assessing the rate of bone graft healing with the recently developed bone-seeking radiopharmaceuticals 99mTc-polyphosphate and 99mTc-diphosphonate. These were utilized to evaluate graft materials placed in surgically created 2-cm defects in the ulnae of mongrel dogs. Radiopharmaceutical scanning was found more sensitive for serial assessment of bone healing than roentgenography. This new method could be an extremely useful clinical tool for evaluating healing of various skeletal abnormalities.