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USUAL VALUES OF GLOMERULAR FILTRATION RATE BY THE CG, MDRD AND CKD-EPI METHODS IN A SENEGALESE ADULT POPULATION

The estimation of the glomerular ltration rate (GFR), whose formulas are usually based on serum
creatinine, is a fundamental data in clinical nephrology. The concept of “reference” or usual values
adopted by health professionals is essential because of the paucity of research on the usual values of GFR in black Africa. The
Modication of Diet in Renal disease (MDRD) and Chronik Kidney disease-Epidemiology collaboration (CKDEpi) equations
were determined in non-African populations. Usual values specic to the black African population by the evaluation of the
formulas of Cockroft and Gault (CG), MDRD and CKD-Epi must be rigorous and are the subject of this study. The GFR was
determined using the CG, MDRD and CKD-Epi formulas in a sample of 233 presumed healthy Senegalese adults (118 men, 115
women). SPSS and Excel 2016 software were used for statistical analysis. A value of P<0.05 was considered statistically
signicant. The determination of the GFR by the Cockcroft method overestimates the CKD values by 10.24 (9.82 - 14.53) with
p=0.001 and that of the MDRD by 7.47 (5.91 - 9.03) the CKD values with p=0.001. For a GFR measurement uncertainty of +/-
10%, the CG and CKD formulas cannot be superimposed with a low correlation coefcient r = 0.52 and a coefcient of
determination R² = 0.28; whereas those of MDRD and CKD-Epi are on the other hand superimposable with r = 0.79 and R² =
0.63. Thus, the CKD-Epi formula should be preferred for determining the usual value of GFR in a healthy person.