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Factors regulating ethanol tolerance.

Ethanol tolerance is a complex phenomenon. Its development is governed by pharmacological and behavioural, as well as genetic factors. The doses of ethanol employed and the duration of ethanol treatment are important pharmacological variables. Behavioural factors such as experience of intoxication and Pavlovian conditioning may also affect the development or manifestation of ethanol tolerance. Genetic factors can influence the development of tolerance directly or/and indirectly through its influence on the initial sensitivity to ethanol. The relevance and implication of tolerance, particularly conditioned tolerance in alcohol abuse and alcoholism, are discussed.