{'fraction_non_alphanumeric': 0.07628643396905362, 'fraction_numerical': 0.05397625044980209, 'mean_word_length': 4.731958762886598, 'pattern_counts': {'":': 0, '<': 3, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
GP270 Health problems in neonates with perinatal HIV exposure

Introduction Antenatal and perinatal periods determine the potential of a child’s health for near and distant future. Considering the increasing number of HIV-exposed uninfected newborns (especially in areas of high risk of HIV infection), the aim of our study was to determine the prevalence of health problems of newborns who avoided perinatal HIV transmission. Methods We conducted a cohort randomized study that included 177 children from birth to 18 months of life. The sample was divided in two groups, equivalent in sex: the main group (n = 87, random sample) comprised neonates with perinatal HIV exposure, the comparison group included children with no HIV exposure (matched sample). Exclusion criteria were confirmed HIV infection (n = 3), and parents’ refusal to participate (n = 0). We evaluated the frequency (Pabs/P%) of seven signs (prematurity, intrauterine growth retardation, neonatal abstinence syndrome, abnormalities of postnatal adaptation, perinatal damage of CNS, congenital and perinatally-acquired infections, congenital malformations and/or minor developmental abnormality). A comparative analysis was performed using the χ2 criterion and its modifications (Yates corrected Chi-square, two-tailed Fisher exact p), relative risk index was calculated (RR [CI0.95]). Results Health problems in neonates according to the analyzed signs were significantly more frequent in main group (76/87.6%) than in comparison group (28/31.1%) (RR = 2.8 [2.0–3.9]; χ2 = 57.75, p <0.0001). In contrast with children, not exposed to HIV, children of HIV-infected mothers showed statistically significant incidence of the following signs: intrauterine growth retardation: 26/29.9% vs 5/5.5% (RR = 5.4 [2.2– 13.4]; χ2 = 16.5, p <0.0001); abnormalities of postnatal adaptation: 14/16.1% vs 3/3.3% (RR = 4.8 [1.4–16.2]; -, p = 0.005); congenital and perinatally-acquired infections: 17/19.5% vs 7/7.8% (RR = 2.5 [1.1–5.7]; χ2 = 5.2, p = 0.022); neonatal abstinence syndrome 12/13.8% vs 0/0% (RR = 25.9 [1.6–430.1] - calculated by L.A. Pevnitsky’s method; -, p <0.0001); perinatal CNS damage: 30/34.5% vs 15/16.7% (RR = 2.1 [1.2–3.6]; χ2 = 7.4, p = 0.007). The most severe problems (frequency of occurrence and the number of registered conditions) were found in HIV-exposed children in families with low income and families where adults had alcohol and/or drug dependence. Conclusions Health problems, relating to disorders in intrauterine growth and early postnatal period are registered mostly in HIV-exposed uninfected children, born to HIV-positive mothers. Increased incidence of health problems and their concentration in low-income families with deviant lifestyle requires careful approach by pediatricians.