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SERUM SICKNESS-LIKE REACTIONS TO CEFACLOR: ROLE OF HEPATIC METABOLISM AND INDIVIDUAL SUSCEPTIBILITY

The findings indicate that cefaclor-associated serum sickness-like reaction may be a unique adverse drug reaction that requires biotransformation of the parent drug and may be associated with inherited defects in the metabolism of reactive intermediates. The condition can be retrospectively confirmed with an in vitro lymphocyte-based cytotoxicity assay. This assay is specific for cefaclor and does not cross-react with cephalexin.