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Anger expression and the risk of cardiovascular disease among urban and rural Japanese residents: The Circulatory Risk in Community Study (CIRCS).

OBJECTIVE
Urbanization, which has been expanding rapidly for the past several decades, has been suggested to increase the risk of cardiovascular disease (CVD) associated with psychological factors such as anger, but the evidence is limited. We examined the hypothesis that urbanicity modifies the association of anger expression with the risk of CVD.


METHODS
A prospective study was conducted in 5,936 residents of urban and rural communities, aged 40 to 79, who had completed an annual health checkup including a questionnaire on anger expression between 1995 and 1998. Associations of anger expression with the risk of CVDs were examined using Cox proportional hazards models, after adjusting for classical cardiovascular risk factors.


RESULTS
During a median follow-up of 16.6 years, we identified 312 incident CVDs. The mean (standard deviation) of anger expression was 24.7 (SD=5.8) among urban residents and 24.6 (SD=5.7) among rural participants (p = .87). Among urban residents, anger expression was positively associated with the risk of total CVD: the multivariable hazard ratio (95% confidence interval) was 1.27 (1.05, 1.54). In contrast, no association was found among rural residents: the corresponding ratio (interval) was 0.96 (0.85, 1.09), with a significant interaction between urban and rural residency with anger expression for incident CVD (p = .047). Similar associations were observed with the risk of CVD subtypes, including ischemic stroke and ischemic cardiovascular disease.


CONCLUSIONS
We found a positive association between anger expression and the risk of CVD among urban residents but not rural residents, suggesting that urbanicity enhances the anger-CVD association.