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Clear Cell Variant of Ductal Carcinoma in situ of the Breast

only focally with a-smooth muscle actin and CD34. No immunoreactivity was obtained with cytokeratins, hcaldesmon, HMB-45, S-100 protein, CD68, and myogenin. The morphologic and immunohistochemical features of the present case are consistent with the diagnosis of ‘‘epithelioid cell myofibroblastoma (MFB)’’. This is a very rare variant of MFB that may represent a diagnostic challenge due to the alarming features exhibited by neoplastic cells. Pathologist should be aware of this morphologic variant of mammary MFB to avoid confusion with malignant tumors such as invasive apocrine carcinoma, histiocytoid variant of invasive lobular carcinoma, and epithelioid cell leiomyosarcoma, especially when dealing with small biopsies.