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Assessment of Serum Antibodies in Patients With Rapidly Progressive SensorineuralHearing Loss and Meniere's Disease

The immunoreactivity of sera from patients with rapidly progressive sensorineural hearing loss (SNHL) or Meniere's disease with bovine inner ear material was determined using the Western blot technique. Patients with other otologic conditions, autoimmune disorders, or arthritic disorders and age‐matched randomly chosen patients with no hearing complaints served as controls. Twenty‐two percent of the patients with bilateral rapidly progressive SNHL and 30% of the patients with Meniere's disease had antibodies that reacted with a 68 kd antigen in the inner ear material. In the control groups, the incidence of reactivity was 5.0% (P<.001).