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Comparative Study to Evaluate Attenuation of Haemodynamic Changes during Laryngoscopy and Endotracheal Intubation Using Intravenous Esmolol and Intravenous Dexmedetomidine

BACKGROUND Dexmedetomidine a highly selective α2 ‑ adrenoreceptor agonist and esmolol an ultra ‑ short ‑ acting β1 ‑ cardioselective adrenergic receptor blocker appear to be quite suitable to control the detrimental effects of laryngeal and tracheal stimulation. The study was conducted to compare the efficacy of dexmedetomidine and esmolol for attenuation of hemodynamic responses to laryngoscopy and intubation were observed and statistically analysed. A statistically significant difference (p < 0.01) between Groups D and E was observed in mean heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) during intubation, 1 min, 3 min, 5 min & 15 min after intubation. Dexmedetomidine was better as compared to esmolol in attenuation of hemodynamic response to laryngoscopy and tracheal intubation.