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Clustering of discrete cell properties essential for tumorigenicity and metastasis. II. Studies of syrian hamster embryo fibroblasts transformed by rous sarcoma virus

Tumorigenic and metastasizing activities (TGA; MA) and susceptibility, or resistance to H202 and PGE‐releasing activity (H2OR2 + PGEs+ phenotype) have been examined in 6 Syrian hamster embryo cell strains transformed in vitro with Rous sarcoma viruses (Schmidt‐Ruppin and Prague strains). Early observations of extremely high level of TGA and even MA of RSV‐SR‐transformants never selected in vivo have been confirmed. The correspondence of these properties with a high level of expression of H2OR2 + PGEs+ phenotype and its clustering character were demonstrated in 4 RSV‐SR trans‐formants, while significantly lower expression of all these characteristics, including TGA, was observed in 2 RSV‐Prague transformants. High level of spontaneous MA was noticed in some RSV‐SR transformants. A tumor cell line induced in vivo by RSV‐SR did not differ from the cell strain transformed in vitro by RSV‐SR. inhibition of H2OR2 + PGEs+ phenotype in one of RSV‐SR transformants was obtained with non‐toxic doses of BCNU and indomethacin, leading to a marked decrease of TGA.