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The significance of hyponatraemia in liver failure

It is possible by means of peritoneal dialysis to correct hyponatraemia occurring in liver failure. The normalization is not, however, attended by any apparent improvement in liver function, hepatic encephalopathy or renal function. Likewise correction of the serum ammonia level did not improve the clinical picture. A correction of the extracellular ion concentration and a possible more normal intracellular composition achieved by peritoneal dialysis may thus eliminate one life-threatening factor in severe liver failure. However, this does not seem to improve the chances of survival of the patients.