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EFFECTS OF END‐TIDAL CONCENTRATIONS OF CYCLOPROPANE, HALOTHANE AND DIETHYL ETHER ON PERIPHERAL AUTONOMIC NEUROEFFECTOR SYSTEMS IN THE RAT

1 The effects of the inhalation anaesthetics, cyclopropane, halothane and diethyl ether were examined on peripheral neuroeffector systems in the pithed and in the conscious rat. 2 In the absence of a suitable means of accurately quantifying doses of inhalation anaesthetics given to small animals, an apparatus was constructed whereby end‐tidal gas samples were collected semi‐automatically from the mechanically ventilated rat. 3 Cyclopropane (15.3 and 29.3% end‐tidal), halothane (0.20, 0.52 and 0.83% end‐tidal) and diethyl ether (2% and 4% end‐tidal) lowered the arterial pressure of the pithed rat. Heart rate was increased by diethyl ether 4%, decreased by halothane and unchanged by cyclopropane. 4 While each anaesthetic depressed the pressor responses to sympathetic nerve stimulation, cyclopropane increased and halothane and diethyl ether depressed the pressor responses to exogenous noradrenaline. 5 Each anaesthetic reduced the motor responses of the smooth muscle of the colon to parasympathetic stimulation. 6 The significance of the effects on peripheral neuroeffector systems is discussed in relation to the overall circulatory changes produced by these anaesthetics in the whole animal.