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Exercise Counters the Age-Related Accumulation of Senescent Cells

The beneficial effects of exercise are in part mediated through the prevention and elimination of senescent cells. We propose the beneficial effects of exercise are in part mediated through the prevention and elimination of senescent cells. Exercise counters multiple forms of age-related molecular damage that initiate the senescence program and activates immune cells responsible for senescent cell clearance. Preclinical and clinical evidence for exercise as a senescence-targeting therapy and areas needing further investigation are discussed.