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PROSTACYCLIN FORMATION BY THE PREGNANT HUMAN MYOMETRIUM

Human myometrium taken between 15 and 42 weeks of pregnancy released a material in vitro which possessed anti‐aggregatory activity. This material parallelled authentic prostacyclin in this action; it possessed a similar stability at alkaline pH and generation of activity was inhibited by indomethacin. Production of the prostacyclin‐like material by the myometrium was similar at weeks 15 and 38 of pregnancy but a 4‐fold increase in synthesis had occurred by 40 weeks. It is suggested this increase may be important for parturition.