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Prospective study of gentamicin locking of tunnelled dialysis catheters: the effect on infection rates and CRP.

To the Editor: Furthering the study recently published from this unit on the utility of antibiotic-locking of tunnelled dialysis catheters1, we report data obtained from the unitwide adoption of this policy. Tunnelled catheters are widely used for hemodialysis access, but their use is restricted by catheter-related infection (CRI)2. Our original randomized controlled study indicated that using a combination of gentamicin and heparin for prophylactic filling of new catheters was effective at reducing CRI1.