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Epithelioid leiomyosarcoma: Case report and review of the literature

A 24-year-old woman, with an unremarkable family and personal hisory, was seen with a localized, nodular, firm and bilobed lesion, with smooth and shiny surface measuring 0.5 × 0.5 × 0.5 cm (0.19x × 0.19 × 0.19 in), on the superior eyelid (Fig. 1). The lesion was asymptomatic and had appeared 6 months previous. An excisional biopsy was taken, but within 1 month the lesion recurred as two 1–2-mm nodules aside the scar. A second excision was then performed. The histology showed a nodular tumor composed of spindle cells with vacuolated cytoplasm in the reticular dermis (Figs 2 and 3). Immunohistochemistry reported positivity for actin, vimentin and cytokeratin and negative for desmin. The diagnosis of an epithelioid leiomyosarcoma was made. After a 2year follow up the patient was free of disease and is still under surveillance.