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Toward a cure for chronic lymphocytic leukemia: an attack on multiple fronts

Recent developments in molecular therapeutics have armed us with powerful tools to mount a multifaceted offensive against CLL, of which BCL2-targeting agents are a critical element. A strategy consisting of initial debulking of leukemia cells in the periphery (chemoimmunotherapy), fostering exit of neoplastic B cells from the protective environment (B-cell receptor-targeting agents) and killing cells in the protective niche (drug combinations) is poised to dramatically reduce residual disease, prolong progression-free survival, increase overall survival and ultimately improve the lives of millions of CLL patients. We believe it is time to start using all these drugs in rationally designed combination trials.