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HTLV-III/LAV-seronegative, virus-negative sexual partners and household contacts of hemophiliacs.

To the Editor.— Public concern about the transmissibility of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) has been heightened by several reports suggesting the existence of an antibody-negative, virus-positive state in some asymptomatic sex partners of persons who are antibody positive. 1-5 We recently evaluated 88 household members and/or sex partners of persons with hemophilia and found that only two nonhemophiliacs were HTLV-III/LAV antibody-positive. 6 We report herein the results of culturing peripheral blood lymphocytes of 20 of the nonhemophiliac contacts whose index hemophiliac was antibody positive. Report of a Study.— These contacts included ten of 14 sex partners of 12 persons with either the acquired immunodeficiency syndrome (AIDS) or the AIDS-related complex, two of 16 sex partners of asymptomatic hemophiliacs, and eight household members who were not sex partners (four fathers, three mothers, and one brother of six asymptomatic hemophiliacs aged 5 to 13 years). Sex partners reported