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ALTERATIONS IN CYCLIC AMP METABOLISM ASSOCIATED WITH PHOTORECEPTOR CELL DEGENERATION IN THE C3H MOUSE 1

Previous studies have shown an abnormality in cyclic nucleotide phosphodiesterase activity in the retina of mice (C3H/HeJ) with an inherited degeneration of the photoreceptor layer. Adenyl cyclase activity and cyclic AMP content have been measured in C3H retina and compared with that in normal retina (DBA/1J) during postnatal maturation, to assess the influence of the mutation upon cyclic AMP metabolism. Adenyl cyclase activity increases normally for the first 7 days of age; thereafter, it becomes greater than normal. Cyclic AMP becomes obviously abnormal after 10 days of age. The elevated levels of cyclic AMP persist in the surviving cells of the inner layers of the adult C3H retina. Adenyl cyclase activity and cyclic AMP content are concentrated in the inner layers of the normal retina, while the photoreceptor layer has only a very low level of enzyme activity and cyclic AMP. The data suggest that the synthesis of cyclic AMP in the inner layers of C3H retina is significantly enhanced, during the period of postnatal development in which the photoreceptor cells have begun to degenerate.