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The Impact of CAGE Data on Understanding Macrophage Transcriptional Biology

This chapter demonstrates the relevance of CAGE data to studying promoter biology in depth. In particular, we report here what we have learned by from CAGE data obtained from macrophages, which are critical cellular mediators of innate immunity. Understanding transcriptional regulation and gene regulatory networks underlying basic biological mechanisms in these cells is key to understanding their physiological and pathological roles. The knowledge and methodological approaches to understanding macrophage biology outlined in this chapter can be applied to cells and tissues in diverse biological systems.