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Disseminated intravascular clotting in kwashiorkor TABLE I Clinical and laboratory data in two groups of kwashiorkor

Hassanein, E. A., and Tankovsky, I. (1975). Archives of Disease in Childhood, 50, 308. Disseminated intravascular clotting in kwashiorkor. The role of disseminated intravascular clotting (DIC) in the pathogenesis of the bleeding diathesis kwashiorkor was investigated in 22 patients. According to the severity of the clinical and haematological findings, two grades of DIC were observed. A severe grade of DIC was shown in 6 cases (5 fatal) presenting with thrombocytopenia, hypofibrinogenaemia, and multiple coagulation defects, and with abnormally prolonged partial thromboplastin, prothrombin, and thrombin times. A second group of 16 patients (7 fatal) showed a less severe grade ofDIC manifested by thrombocytopenia, low fibrinogen level, and a clotting factor defect shown by prolonged prothrombin and thrombin times.