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Tablet Formulation and Enhancement of Aqueous Solubility of Carisoprodol by Solvent Evaporation Co-Crystal Technique

Abstract The improvement in the aqueous solubility, physicochemical and micromeritics property of insoluble and slightly soluble drugs is of major concern in pharmaceutical formulations. It is commonly observed in the durg industry that on average more than 35 % of newly discovered drugs are poorly water-soluble. Poor “drug like” properties of lead compounds led to ineffective absorption from the site of administration, less bioavailability which has been designated as an important part of the high clinical failure. In the present work, Carisoprodol, centrally acting skeletal muscle relaxant belongs to BCS class II drug (highly permeable and low soluble). A simultaneous differential scanning calorimetry (DSC), Fourier transforms infrared (FT-IR), XRPD microspectroscopy, SEM, dissolution study and micromeritics properties study was used to quickly investigate the co-crystal. Tablet formulation was developed by direct compression method and there evaluation was performed.