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Partial Seizure Provoked by Hyperbaric Oxygen Therapy: Possible Mechanisms and Implications

Summary:  Hyperbaric oxygen treatment (HBO2) is used commonly for treatment of bone and soft‐tissue radiation necrosis. It may be a potential therapy for radiation necrosis seen after brain irradiation. HBO2 risks include generalized tonic–clonic convulsions. We report a patient after resection of anaplastic astrocytoma and 5,580 cGy of total external‐beam radiation treatments with brain radiation necrosis who underwent HBO2 therapy and developed a partial seizure during treatment. Mechanisms and implications are discussed.