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Comparison of diagnostic accuracy between linear EUS and miniprobe EUS for submucosal invasion in suspected early gastric cancer.

OBJECTIVE
This study assessed the accuracy of linear endoscopic ultrasound (EUS) in diagnosing submucosal (SM) invasion and compared linear EUS with mini-probe EUS in suspected early gastric cancer (EGC) patients.


METHODS
Patients diagnosed with biopsy-verified suspected EGC were analysed retrospectively. They were all examined by linear EUS or miniprobe EUS for preoperative diagnosis of invasion depth and underwent endoscopic or surgical treatment for radical resection. The invasion depth evaluated by EUS and pathology were categorized into no invasion of SM and invasion of SM or deeper. We compared the diagnosis of EUS with postoperative pathology results.


RESULTS
A total of 105 patients were included in the final analysis. We found that the overall prediction accuracy of linear EUS (n = 57) for SM invasion in suspected EGC was higher than that of mini-probe EUS (n = 48), but no statistically significant differences were noted (82.5% vs 72.9%, p = 0.344). The negative predictive value (NPV) of linear EUS was significantly higher than that of mini-probe EUS (100% vs 82.8%, p = 0.037). The binary logistic regression analysis identified that tumor size (p = 0.036), the presence of ulceration (p < 0.001) and the EUS type (p = 0.027) were independent risk factors for the diagnosis of SM invasion by EUS. The area under the receiver operating curve (ROC) was 0.889 and 0.719 for linear and mini-probe EUS, respectively.


CONCLUSION
Linear EUS diagnosed suspected EGC for SM invasion with higher accuracy than mini-probe EUS. Additionally, large and ulcerative lesions may lead to overestimation.