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Antifungal compounds redirect metabolic pathways in yeasts: metabolites as indicators of modes of action

Aims:  Metabolic pathways, e.g. biosynthesis of ergosterol or carbohydrate metabolism including respiration, are well‐known targets of several fungicides. With our study we wanted to prove that metabolite profiles can be used to classify fungicides according to their mode of action and that concentrations of key metabolites are changed even without detectable reduced growth rates.