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Assessment of Behavioural Flexibility and Executive Function Using Novel Touch Screen Paradigms

The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative has recently identified a NIMH consensus cognitive battery comprising seven major domains for use in clinical trials assessing cognitive impairment associated with schizophrenia (CIAS). Major cognitive domains identified include Attention/Vigilance (assessed using variants of the continuous performance test), Visual Learning and Memory (e.g., visuospatial memory tests), Working Memory (e.g., spatial span or delayed response tasks), Speed of Processing (e.g., trail-making) and Reasoning and Problem-Solving. There is a great need for a biologically and statistically-validated consensus cognitive test battery for rodents which can reliably translate to these CIAS clinical endpoints. Here we report on the development of three novel touchscreen-based tasks for the rodent – a 3-Stimulus Discrimination and Reversal test, a Continuous Performance test, and a Self-Ordered Working Memory test – that tap into several of the CIAS domains, and have responses requirements and outcome measures that are highly related or identical to those used in clinical assessment.