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Effects of Acadesine on the Incidence of Myocardial Infarction and Adverse Cardiac Outcomes after Coronary Artery Bypass Graft Surgery

Background Acadesine (AICA riboside) (5-amino-1-[beta-D-ribofuranosy]imidazole-4-carboxamide) is a purine nucleoside analog belonging to a new class of agents generally termed adenosine regulating agents (ARAs) that increase the availability of adenosine locally in ischemic tissues. The effects of acadesine on the incidence of fatal and nonfatal myocardial infarction (MI) and on the incidence of all adverse cardiovascular outcomes (cardiac death, MI, congestive heart failure, life-threatening dysrhythmia, or cerebrovascular accident) was investigated in patients undergoing coronary artery bypass graft (CABG) surgery.