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[Etiological analysis and in vitro drug sensitivity of bacterial keratitis in northern China in the period of 2006-2015].

Objective: To analyze the etiology and drug sensitivity of bacterial keratitis and their changes, and to provide evidence for treatment and drug selection of bacterial keratitis. Methods: Retrospective case series study. From January 2006 to December 2015, corneal specimens suspected of bacterial infection were collected and cultured in Beijing Tongren Eye Center. General information of patients, etiological results and drug sensitivity test results were summarized and analyzed. The Chi-square test and Spearman correlation analysis were performed using SPSS 20.0 software. Results: A total of 6 220 corneal specimens were collected, and 1 133 of them were positive. The positive rate was 18.2%. Among the positive specimens, 673 were from males and 460 were from females, aged from 11 days to 94 years old, with an average age of (45.3±22.1) years old. Among all isolated bacteria, 741 strains of Gram-positive cocci accounted for 62.0%, and 303 strains of Gram-negative bacilli accounted for 25.2%. Three hundred and twenty-one strains of Staphylococcus epidermidis was the most common isolates, accounting for 26.9% of all bacteria isolated, which was followed by 131 Strains of Pseudomonas aeruginosa (11.0%). In vitro drug sensitivity test results of 11 antibiotics showed that the sensitivity rate of gatifloxacin was highest, while the sensitivity rate of tobramycin and ceftazidime was lower than the other drugs. Multi-drug resistant bacteria accounted for 29.2% of all bacteria isolated. Conclusion: Bacterial species causing corneal infection are changing over time in northern China within recent 10 years. Staphylococcus epidermidis is the most common bacteria isolated. The sensitivity rate of corneal bacteria to the fourth generation of fluoroquinolone antibiotics represented by gatifloxacin is highest. (Chin J Ophthalmol, 2017, 53: 662-667).