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An Unusual Sialoglycoprotein Associated with the Webb‐Positive Phenotype

Abstract. This paper presents the results of a study on the erythrocyte membrane proteins from Webb‐positive individuals. The membrane proteins were separated by polyacrylamide electrophoresis and stained using a Silver stain as well as Coomassie blue and PAS stains. All Webb‐positive individuals exhibited a decrease in the β‐sialoglycoprotein βSGP band along with the appearance of a new SGP 3,000 daltons less than βSGP. It is postulated that this band is an abnormal βSGP possibly lacking the N‐linked oligosaccharide that is normally present in β‐SGP.