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Postmortem MRI Changes of the Brains of the Rats of Different Ages

Brain degenerative changes were studied in the rats of different ages after cervical dislocation by T2 MRI and histology. Appearance of dark spots in the T2 images increased with increased duration after death. Quantitative analysis of the density of these spots revealed that the neonatal (1 week) and the old (9 months) animals had accelerated degenerative changes when compared with the young adult (1 month). The degenerative changes correlated with the accumulation of vacuoles or spaces in the brain tissue histologically. This study pointed out not only brain degenerative changes after death were associated with age, it also revealed that the MRI T2 evaluations could be used as a way in postmortem investigation.