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[Assessment of the efficacy and tolerability of melatonergic antidepressant treatment in patients surgical correction of the appearance].

Objective. To study the efficacy and tolerability of agomelatine (valdoxan) in the treatment of affective disorders developed after surgical correction of the appearance. Material and methods. We summarized 35 cases characterized by the development of ICD-10 depressive disorders after the face surgery performed to correct congenital and acquired malformations. Agomelatine was prescribed in dose 25-50 mg daily during 6 weeks. Patient's state was assessed using psychopathological method and psychometric scales. Results and conclusion. We obtained significant results demonstrating the efficacy of this drug in mild and moderate depressive disorders. Agomelatine had a favorable tolerability profile that provided a high level of compliance of the patients.