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Glutamine nutrition: theoretical considerations and therapeutic impact.

In critically ill surgical patients, nutritional therapy is an important component of overall care. As our knowledge increases, "tailor-made" diets designed to meet specific nutritional requirements in specific patients may play an important role. Although the data reviewed here suggest that glutamine-supplemented diets may have a significant impact in some clinical settings, it should be emphasized that additional carefully designed studies are necessary before the use of glutamine-enriched nutrition in critically ill patients should be advocated. It is clear, however, that the concept that the intestine is an organ of inactivity during critical illness merits reconsideration.