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A role for Paf‐acether (platelet‐activating factor) in acute skin inflammation?

Paf-acether was first described as originating from basophils in IgE-sensitized rabbits challenged with the specific antigen (Benveniste, Henson & Cochrane, 1972). Research on this mediator has gained importance in recent years because of the elucidation of its structure. Its release from phagocytic cells (neutrophils, macrophages) and platelets has enlarged its role in the participation in the inflammatory process (Roubin et al., 1983). Inflammation is initiated by the presence of foreign bodies and characterized, in general, by increased vascular permeability. Such an increase of permeability can be mediated by some mediators or indirectly by their action on other cells. In this respect Paf-acether represents a good example of a mediator released by and acting on inflammatory cell types. For instance platelets, the first described targets of Paf-acether, are able to produce a variety of infiammatory mediators: proteases, permeabilityinducing agents (histamine, serotonin, cationic proteins), arachidonic acid derivatives and chemo-attractants that will perpetuate the infiammatory reaction. In addition, Paf-acether is now known to be a potent inducer of vascular permeability and neutrophil-activating factor.