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Acute Liver Failure During Pirfenidone Treatment Triggered by Co‐Medication With Esomeprazole

Prifenidone is an antifibrotic agent for the treatment of Idiopathic Pulmonary Fibrosis (IPF) that improves the outcome of patients and is recommended by guidelines [1]. In few patients however, Pirfenidone can cause liver enzyme elevations according to LiverTox [2], with one case report describing acute liver failure [3]. We here present a patient in whom co-medication with Esomeprazole triggered iDILI. This article is protected by copyright. All rights reserved.