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Next-Generation Sequencing and Eating of the Tree of Knowledge

Clonal hematopoiesis is common, and the large-scale sequencing of patients’ tumors in the clinical setting is becoming very common. The incidence of falsely reporting clonal hematopoiesis as tumor associated in patients with solid tumors is a concern, as it may lead to unintended consequences. See related article by Coombs et al., p. 5918