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Letter to the Editors

Sirs, There have been two reports suggesting an association of Wiedemann-Beckwith syndrome (WBS) and chromosome abnormalities involving the short arm of chromosome 11 (Waziri et al. 1983, Turleau et al. 1984). Schmutz recently reported in Clinical Genetics (30: 154-156; 1986) finding a deletion in chromosome 1 1 (pl lp13) in a child with WBS. However, there appear to be a number of problems in this report. First, the description of the physical findings is minimal, and the reported findings are not adequate to support a diagnosis of WBS. Only two physical findings suggestive of WBS are present (increased birthweight and possible macroglossia). There was no visceromegaly present nor other commonly associated physical malformations. Secondly, the family history is not mentioned. It has been strongly suggested that WBS is an autosomal dominant with incomplete penetrance (Niikawa et al. 1986, Pettenati et al. 1986). A thorough family history with physical examination for minor expression of WBS is essential. Thirdly, the resolution of the chromosomes presented is poor. When dealing with a cytogenetic abnormality such as is associated with WBS, high resolution cytogenetic analysis is essential. Lastly, it would appear that in Figure 1 the normal chromosome 11 in the upper left hand corner is a chromosome 12. It is my hope that Schutz will reinvestigate this case in order to provide us with further information needed for better understanding of WBS. Mark Pettenati