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THE SAFE TRANSDERMAL COSMETIC PRODUCT WITH ANTITYROSINASE ACTIVITY

The possibility of developing a cosmetic product with antipigmentation properties has been considered. The cream is based on extracts, selected by monitoring, from plant components spread in Ukraine, able to inhibit tyrosinase and thus impart antipigmentation properties to the product. As active components expanding the range of the product’s cosmetic properties, ingredients were selected that strengthen the skin matrix and saturate it with essential substances. To enhance the effectiveness of the biologically active constituents of the product, liquid crystals based on cholesterics as modern systems of transdermal delivery of active components (0.1%) were included in its composition. For the cosmetic product, it has been suggested to use the following thermotropic cholesteric composition: cholesteryl nonanoate – 45%, cholesteryl pentanoate – 25%, cholesteryl-4-nonylbutanedioate – 30%. According to the complex of the organoleptic, physico-chemical, biochemical, and microbiological quality parameters of the new product after its manufacture and storage during three months, it has been established that it complies with the general sanitary and hygienic requirements to perfumes and cosmetics of the 3rd group. Biotesting on the testing cultures Allium cepa L. and Saccharomyces cerevisiae has proved the complete integral safety and growth potentiation of both testing cultures by 9.6–19.3% to the control, even in the presence of a preservative. This is an evidence of the safety, biological activity, and advisability of the developed cosmetic product with antipigmentation properties, containing cholesteric liquid crystals. The cosmetic product, based on the formulation developed, has been tested on female volunteers. Its effectiveness has been established and a simultaneous increase in the face skin humidity has been proved instrumentally.