{'fraction_non_alphanumeric': 0.04828551434569629, 'fraction_numerical': 0.02239328201539538, 'mean_word_length': 4.72, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
INFLUENCE OF SELENIUM SUPPLEMENTATION ON THE HEPATIC SELENOENZYMES IN MICE FED WITH HIGH IODINE DIET

Objective: To observe the influence of selenium supplementation on the hepatic selenoenzymes in mice fed with high iodine diet and to explore the mechanism. Methods: Forty weanling female Balb/C mice were assigned into 4 groups and given drinking water including different doses of iodine and selenium: normal control (NC, tap water),high iodine group (HI, 3.0 mg/L I),high iodine+selenium group 1 (HI+Se 1,3.0 mg/L I +0.5 mg/L Se) and high iodine + selenium group 2 (HI+Se 2,3.0 mg/L I +1.0 mg/L Se). Five months later, the related indices were determined. Results: The mice in HI group showed colloid goiter. Compared with NC group, serum TT4 increased and TT3 decreased significantly in HI groups. Two Se supplementation groups inhibited the increase of TT4 and the decrease of TT3. In HI group, the liver Se reduced, MDA increased,activity of GSH-Px and deiodinase 1(DI-1)were reduced 47% and 33% respectively,and mRNA expression of DI-1 also down-regulated. Se supplementation obviously increased the hepatic selenium, enhanced the activity of GSH-Px and DI-1 and mRNA expression of DI-1. However,increase of Se supplementation from 0.5 to 1.0 mg/L did not further increase selenoenzyme activity and expression. Conclusion: Intervention of Se on the iodine-induced abnormalities is fulfilled by its effect on selenoenzyme.