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Response to Howard and Howard

viduals, even if LDL size is larger or in vitro susceptibility to oxidation is diminished. Statements to the contrary should be established by clinical trials before their acceptance for the care of patients with diabetes. Improvement in insulin sensitivity in type 2 diabetes would be expected to improve the dyslipidemia associated with this syndrome. The relative role of this dyslipidemia versus LDL cholesterol concentrations in the etiology of CVD in diabetic individuals remains an unanswered question. Interventions aimed at investigating this issue are needed.