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Antidiabetics with Herbs : A compressive Review on Interactions.

Diabetes mellitus is chronic illness with variety of causes and pathophysiology. For the management of diabetes various synthetic antidiabetic drug available but people also preferred complementary and alternative therapies as well as traditional herbal home remediesbecause they are perceived to be free of side effects and generally recognized as safe due to their natural origin. Worldwide majority of population is consuming herbs and/or herbal product in their daily routine. It has been observed that diabetic individuals also consume herbs/herbal products either with or without medical supervision. This co-consumption of antidiabetic medications and herb/herbal products may result in to some herb-drug interactions which might be potentially beneficial or harmful or fatal also. Most of the times, these interactions remain unnoticed or undiagnosed due to lack of knowledge and awareness about them In this review authors have summarized some important aspects related to the herb-drug interaction (HDI), which include methods for prediction and mechanism of HDI (pharmacokinetic and pharmacodynamic) and also the clinical and experimental literature on herb-drug interactions (HDI) in the treatment of diabetes and attempt to categorize the interactions between oral hypoglycemic agents and various herbs as beneficial and harmful drug interactions on the basis of results reported in original research work.