{'fraction_non_alphanumeric': 0.039186507936507936, 'fraction_numerical': 0.022817460317460316, 'mean_word_length': 5.7912457912457915, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Studying the role of sodium Aescinate (Reparildragees) in treatment of Mastalgia

Objectives: To evaluate the effect of Aescinate on the mastalgia patients of benign causes as a synergistic drug with other treatments of modalities. Methods: Female patients (aged 9 to 75 years) with history of benign causedmastalgia (n=517) visited the Imam Ali hospital breast clinic, Baghdad, Iraq, between January 2014 and January 2019, were included. Those who met to the study criteria; 400 patients completed the study,were prospectivelydivided into those who had cyclical mastalgia (n=200) and those who didn’t (n=200), then subdivided into five subgroups (each n=40).For all patients, we evaluated the history of trauma, diet and life style (wearing bra, sleeping prone, drinking caffeine containing drinks, fatty foods), breast size, history of breast infections, hormonal assay, radiological assessment (ultrasound and/or mammography), pain severity/response charts andhistopathological test pre and post-treatment. The observation follow-up were made at study initiation and accordingly (2 weeks-2 months) visits and at least to 6 months total period with at least 2 menstrual periods within. Results: The Aescinate (Reparildragees) synergistically treated mastalgia with danazolgroups showed a significant reduction in pain charts response 80% for cyclical type and 67.5% for non-cyclical compared to groups not, while for evening primrose oil group were 70% and 60% respectively. Also forhistopathological response which was best for periductalcyclical mastitis for danazol and evening primrose oil with Reparilgroups (77% and 67% respectively) as do nipple discharge (63% and 28 % respectively) over the study period. The cyclical group show more response than noncyclical group for mastalgia, histopathological and nipple discharge after treatment with synergistic Reparildragees. Conclusion: Aescinate (Reparildragees) improve danazol and evening prim rose treatment regimens of mastalgia of benign cause’s response.