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A redox-responsive folate-fluorophore conjugate as a new target-cell-specific imaging probe.

Here we have developed a redox-responsive folate-fluorophore conjugate (RFC) with a disulfide linker for the target-specific imaging of cancers. The quenched fluorescence of the RFC could be turned on after folate receptor-mediated endocytosis and subsequent cleavage of the disulfide linker by intracellular glutathione, enabling target-cell-specific fluorescence imaging with a high target-to-background ratio.