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[Research of regulation on calcium-activated potassium channel in hypothalamic neurons by nitric oxide].

AIM
To study the effects of nitric oxide on calcium-activated potassium channels (KCa) in hypothalamus neurons.


METHODS
The data was recorded by adopting cell-attached or inside-out configuration of patch-clamp technique.


RESULTS
Nitric oxide was found to increase the open probability of the channels directly or through increasing cGMP, which resulted from both the prolongation of open period and increase of open frequency.


CONCLUSION
Nitric oxide could regulate calcium-activated potassium channels in hypothalamic neurons through alternative pathways.