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Estrogen receptor status and response to chemotherapy in advanced breast cancer

Tumor estrogen receptor status in women with advanced breast cancer was correlated with clinical response to cytotoxic chemotherapy in a retrospective study. Following an extramural review of the clinical data of 40 patients, 26 responded to chemotherapy (65%). The response rate in 19 receptor‐rich tumors was 89% and in 21 receptor‐poor tumors, 43% (P < 0.01). The lowest response rate (14%) was observed in seven postmenopausal patients with receptor‐poor tumors. Clinical characteristics of patients and variants in chemotherapy programs failed to explain the favorable response of receptor‐rich tumors to cytotoxic chemotherapy.