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Mitotic changes in neuroblastoma transplanted into denervated host tissue.

Tumors were transplanted to denervated and innervated hind limbs of A/J mice and grown for 5 days in all groups. The host tissues were denervated by femoral and sciatic nerve section 4 days prior to tumor implantation. Dnervation of host tissues resulted in a significant reduction in tumor mitotic rate as assessed by mitotic counts in the histological sections. Neurotrophic factors may thus be an additional feature of the host-tumor environment.