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Inhibition of histidine decarboxylase in rat stomach by aminoguanidine.

Aminoguanidine is a potent and specific inhibitor of diamine oxidase and has been used extensively in studies on histamine metabolism (Buffoni, 1966). One of the consequences of inhibition of diamine oxidase is an increased circulating concentration of histamine, and aminoguanidine is potentially a useful drug for investigating, in vivo, the proposed feedback coupling between histamine and its synthesizing enzyme in the gastric mucosa of the rat (Kahlson, Rosengren & Thunberg, 1967).