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A Greener Approach for Synthesis of Quinoline-3-carboxylate
Building Block and their Biological Screening

The analogs of nitrogen-based heterocycles occupy an exclusive position as a value of more than 75%
of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic
moieties. Among many N-containing heterocycles, quinolines have become important due to their
variety of applications in medicinal, synthetic organic chemistry as well as in the field of industrial
chemistry. Present work gives information about the green and clean synthesis using multicomponent
reactions (MCRs) methods and L-proline and ammonium acetate as a catalyst for the synthesis of
quinoline derivatives. Synthesized quinoline derivatives undergo spectroscopic analysis and their
biological evaluation.