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Isolated dorsal root ganglion neurones inhibit receptor‐dependent adenylyl cyclase activity in associated glial cells

Hyper‐nociceptive PGE2 EP4 receptors and prostacyclin (IP) receptors are present in adult rat dorsal root ganglion (DRG) neurones and glial cells in culture. The present study has investigated the cell‐specific expression of two other Gs‐protein coupled hyper‐nociceptive receptor systems: β‐adrenoceptors and calcitonin gene‐related peptide (CGRP) receptors in isolated DRG cells and has examined the influence of neurone–glial cell interactions in regulating adenylyl cyclase (AC) activity.