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Thyrotropin‐Releasing Hormone and Its Analog MK‐771 Increase the Cerebroventricular Perfusate Content of Dihydroxyphenylacetic Acid

Abstract: The effects of thyrotropin‐releasing hormone (TRH) and its synthetic analog, pyro‐2‐aminoadipyl‐his‐tidyl‐thiazolidine‐4‐carboxamide (MK‐771), were determined on the efflux of dihydroxyphenylacetic acid (DOPAC) collected from push‐pull cannulae chronically implanted into the lateral cerebral ventricles of rats. Intracerebroventricular and intraperitoneal injections of both peptides increased the efflux of DOPAC. These results suggest that TRH and MK‐771 increase the activity of dopaminergic neurons that terminate in periventricular regions.