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VP25.21: Evaluation of brain biometry in fetuses with congenital diaphragmatic hernia on ultrasound and MRI throughout pregnancy

to propose criteria for differential diagnosis with other vermian pathologies. Methods: This multicentre retrospective study enrolled fetuses with confirmed diagnosis of JSRD. US and MRI images were analysed for morphological and biometrical parameters (cerebellum and vermis, 4th ventricle, superior cerebellar peduncles, MTS, brainstem structures, additional CNS and extracerebral findings). The findings were compared to the diagnostic features of common cerebellar disorders (DWM, Blake’s pouch cyst, MCM, other causes of vermian dysgenesis) to propose objective diagnostic criteria for the prenatal diagnosis of this entity. Genetic results were retrieved whenever available. Results: 31 fetuses were enrolled to the study. Gestational age at the diagnosis varied from 15-36 weeks. In 16% of cases the TCD was below the 10th centile, and in 33% it was above the 60th<span style=”font-size:10.8333px”> </span>centile for the gestational age. The 4th ventricle was abnormal in all cases and presented a characteristic abnormal morphology even in the absence of a communication with the CM. The MTS was depicted with all features in 23 cases, presenting variable morphology. Thick and enlarged tectum was a common midbrain finding and ventriculomegaly was the most common supratentorial associated anomaly. Enlarged kidneys and polydactyly were observed in <50% of cases. The present findings allowed to describe clear features for the prenatal diagnosis of this entity. Conclusions: Most cases of JSRD and other molar tooth dysplasias may be distinguished from other causes of vermian hypoplasia by specific imaging criteria, identified by dedicated neurosonography and brain MRI.