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Enhanced osteoinduction by mesenchymal stem cells transfected with a fiber‐mutant adenoviral BMP2 gene

Bone regeneration therapy using mesenchymal stem cells (MSCs) is beginning to come into clinical use. To overcome the difficulty of healing large bone defects, we previously reported the efficacy of using rat mesenchymal stem cells (rMSCs) carrying a modified adenoviral vector (Adv‐F/RGD) with an RGD‐containing peptide in the HI loop of the fiber knob domain of adenovirus type 5 (Ad5).