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280 HYDROXYCHLOROQUINE IN THE TREATMENT OF CHRONIC

We report on our experience in 8 patients with different forms of chronic interstitial lung disease. These included lymphocytic interstitial pneumonitis and chronic bronchiolitis.Clinical presentation consisted in tachypnoea, cyanosis, cough, crepitant rales and failure to thrive.Diagnostic work up included lung function studies in all patients, bronchoscopy with bronchoalveolar lavage (BAL) in 7 patients and open lung biopsy in 4 patients.Therapy included oral and inhaled steroids, inhalation with bronchodilators and oral hydroxychloroquine.While most of the patients did not respond to steroids alone, hydroxychloroquine improved the clinical and laboratory findings in a majority of our patients.Conclusion: Further controlled studies are required for propper evaluation of the effect of hydroxychloroquine in the treatment of chronic interstitial lung disease in children.