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Impact of the high‐molecular‐weight form of adiponectin on endothelial function in healthy young men

Objective  Adiponectin is an adipocyte‐derived, antiatherogenic protein that is present in plasma as a large multimeric structure of high molecular weight (HMW) and in a trimer or hexamer form (non‐HMW). The biological activities of these isoforms have not yet been elucidated. We therefore examined the effect of these isoforms on endothelial function in healthy young men.