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Inhibition of acetylcholine synthesis in neuroblastoma cells by a styrylpyridine analog

A NUMBER of substituted styrylpyridine analogs have been synthesized that inhibit choline acetyltransferase (AcetylCoA: choline 0-acetyltransferase, EC 2.3.1.6; ChAc) activity in homogenates of brain tissue (CAVALLITO et al., 1970). However, it has been reported that they do not inhibit acetylcholine synthesis in uiuo (HEMSWORTH & FOLDES, 1970; AQUILONIUS et al., 1971). We find that at least one such compound inhibits the synthesis of acetylcholine in viable neuroblastoma cells.