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Nonketotic Hyperosmolar Coma and Frusemide Therapy

Nonketotic hyperosmolar diabetic coma developed in a patient with congestive cardiac failure who was treated with frusemide. With the introduction of large doses of frusemide for resistant edema the authors suggest that particular care be taken to exclude the development of diabetes mellitus. Hyperglycemia in a patient with an already established diuresis may lead to lethal hyperosmolar coma.