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Myosin 1g regulates cytoskeleton plasticity, cell migration, exocytosis, and endocytosis in B lymphocytes

Myosin 1g (Myo1g) is a hematopoietic‐specific myosin expressed mainly by lymphocytes. Here, we report the localization of Myo1g in B‐cell membrane compartments such as lipid rafts, microvilli, and membrane extensions formed during spreading. By using Myo1g‐deficient mouse B cells, we detected abnormalities in the adhesion ability and chemokine‐induced directed migration of these lymphocytes. We also assessed a role for Myo1g in phagocytosis and exocytosis processes, as these were also irregular in Myo1g‐deficient B cells. Taken together, our results show that Myo1g acts as a main regulator of different membrane/cytoskeleton‐dependent processes in B lymphocytes.