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Reproduction and growth of progeny of female mice mated after treatment with crufomate.

Effects on reproduction and litter growth were studied for two successive reproductive periods (RP)--interval between caging females with males and whelping--in female mice treated dermally with crufomate at 100 or 50 mg/kg on days 35 and 21 before caging with untreated males. Each treatment with crufomate caused about 50% reversible inhibition of cholinesterase activity without inducing any signs of toxicity. The higher dose reduced the conception rate and the number of litters and young born and weaned during the two RPs. It also reduced the lactation index, weaning weight of males and females, and mature weight of males in the first litter. The lower dose prolonged the gestation period and reduced the lactation index and the number of litters and young weaned in the first RP and conception rate and number of litters and young born and weaned in the second RP. The lower dose reduced the weaning and mature weights of the first litter and mature weight of males in the second litter. The higher dose reduced the body weight and the lower dose increased the adrenal weight of the treated females.