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Current Practice and Pitfalls of Select Biomarkers in the Emergency Care of Children.

Specific biomarker levels can help differentiate children who require emergent medical interventions, such as procedures, surgeries, or antibiotics, from those who may not. Appropriate application of biomarkers after a thorough history and physical examination can potentially improve cost-effective management by minimizing unnecessary procedures and tests without sacrificing patient safety. This issue reviews the literature regarding 4 biomarkers: lactate, C-reactive protein, ferritin, and procalcitonin. Evidence-based recommendations are made for the clinical evaluation of bacterial meningitis, common infections, and appendicitis.