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Selective proton‐observed, carbon‐edited (selPOCE) MRS method for measurement of glutamate and glutamine 13C‐labeling in the human frontal cortex

13C magnetic resonance spectroscopy (MRS) in combination with infusion of 13C‐labeled substrates has led to unique insights into human brain metabolism and neurotransmitter cycling. However, the low sensitivity of direct 13C MRS and high radiofrequency power requirements has limited 13C MRS studies to predominantly data acquisition in large volumes of the occipital cortex. The purpose of this study is to develop an MRS technique for localized detection of 13C‐labeling of glutamate and glutamine in the human frontal lobe.