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Adenosine triphosphate induces P2Y2 activation and interleukin‐8 release in human esophageal epithelial cells

Immune‐mediated mucosal inflammation characterized by the release of interleukin (IL)‐8 is associated with gastroesophageal reflux disease. ATP released by human esophageal epithelial cells (HEECs) mediates the release of cytokines through P2 nucleotide receptors that are present on various cells, including HEECs. This study characterized and identified human esophageal epithelial P2 receptors that are responsible for ATP‐mediated release of IL‐8 by using a human esophageal stratified squamous epithelial model.