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Incidence of Laryngotracheal Stenosis after Thermal Inhalation Airway Injury.

OBJECTIVES
Inhalation injury is independently associated with burn mortality, yet little information is available on the incidence, risk factors, or functional outcomes of thermal injury to the airway. In patients with thermal inhalation injury, we sought to define the incidence of laryngotracheal stenosis (LTS), delineate risk factors associated with LTS development, and assess long-term tracheostomy dependence as a proxy for laryngeal function.


METHODS
Retrospective cohort study of adult patients treated for thermal inhalation injury at a single institution burn critical care unit from 2012 to 2017. Eligible patients' records were assessed for laryngotracheal stenosis (laryngeal, subglottic, or tracheal stenosis). Patient characteristics, burn injury characteristics, and treatment-specific covariates were assessed. Descriptive statistics, Mann-Whitney U-Tests, odds ratio, and Chi-Square Tests compared LTS versus non-LTS groups.


RESULTS
Of 129 patients with thermal inhalation injury during the study period, 8 (6.2%) developed LTS. When compared to the non-LTS group, patients with LTS had greater mean TBSA (mean 30.3, IQR 7-57.5 vs 10.5, IQR 0-15.12, p=0.01) higher grade of inhalation injury (mean 2.63 vs 1.80, p=0.05), longer duration of intubation (12.63 vs. 5.44; p < 0.001), and greater inflammatory response (mean WBC on presentation 25.8 vs. 14.9, p=0.02, mean hyperglycemia on presentation 176.4 vs 136.9, p=0.01). LTS patients had a significantly higher rate of tracheostomy dependence at last follow-up (50% vs. 1.7%, p < 0.001).


CONCLUSION
Six percent of patients with thermal inhalation injury develop LTS. LTS was associated with more severe thermal airway injury, longer duration of intubation, and more severe initial host inflammation. Patients with inhalation injury and LTS are at high risk for tracheostomy dependence. In burn patients with thermal inhalation injury, laryngeal evaluation and directed therapy should be incorporated early into multispecialty pathways of care.