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Characteristics of a population based analysis concerning ventricular volume regulation

Volumetric characteristics of the ventricle in hearts covering a broad pathophysiological range are available from our own investigations, supplemented with data from the literature. The aim of this study is to formulate a unifying description for cardiac volume pump function employing a meta-analysis. Previously, we documented that end-systolic volume (ESV) versus end-diastolic volume (EDV) yields a high linear population based correlation coefficient. Now we describe a universal relationship between both regression coefficients. This notion is derived from a pooled study implying 5,849 patients documented in 258 data sets. We conclude that there exists a significant inverse relationship between the pooled regression slopes and intercepts of the ESV versus EDV representation.