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[Role of cytokine signaling in cardiomyopathy].

Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Cardiac myocytes produce various kinds of cytokines including IL-6 and cardiotrophin-1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocyte via JAK/STAT, MAP kinase and PI-3 kinase pathways. Besides various well-established mechanisms by which myocardial hypertrophy and remodeling are regulated, a gp130 signaling may be a newly discovered mechanism that regulates these events in association with cytoprotective effect in cardiomyopathy. In addition, the activation of gp130 dependent signaling pathway in cardiac myocytes might play a pivotal role in the prevention of heart failure.