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Association between left ventricle diastolic function with body mass index in women 40-60 years old with a preserved ejection fraction

Introduction. Diastolic heart failure is a variant of the universal complication of diseases and heart lesions, characterized by impaired function and myocardial remodeling. Since these processes begin before the onset of symptoms, special attention is paid to identifying subclinical diastolic LV dysfunctions, as a predictor of the formation of heart failure. The objective: was to determine and characterize the prevalence of LVDD in the population of women 40–60 years old depending on BMI. Materials and methods. We examined women aged 40–60 years without clinical signs of heart failure, with preserved LVEF, who underwent an ultrasound examination to identify preclinical LVDD. Diastolic function was divided into normal and DD. Then DD was ranked as mild, moderate, and severe. Statistical processing was performed using Statistica for Windows. Results. Abnormal diastolic function detected in 383 (58.4%) patients, with the most common stage being 1: 359 (93.7%). With stage 2 DD, 23 (6.0%) patients were detected and stage 3 DD was detected in 1 (0.3%). BMI increased in proportion to the stages of DD (p<0.001). More patients with normal diastolic function have normal weight or overweight, while patients with DD were predominantly obese (p<0.001). As BMI increased, the prevalence of normal diastolic function decreased, while the prevalence of DD increased (p<0.0001). Conclusions. An increase in BMI is associated with DD in both groups of patients with obesity, hypertension and diabetes, and in an isolated group of normotensive patients without diabetes. These results may indicate that BMI is an independent predictor of DD. Key words: diastolic dysfunction, obesity, body mass index.