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[Study on the relationship between partial deletions in the azzospermia factor C region of Y chromosome and male infertility].

OBJECTIVE
To investigate the relationship between the partial deletions in the azzospermia factor(AZFc) region of Y chromosome and male infertility.


METHODS
Multiplex PCR technology was performed to screen the partial deletions in the AZFc region in 158 azoospermia, 160 severe oligozoospermia and 135 oligozoospermia patients and 236 men with normal spermatogenesis.For samples with gr/gr, b2/b3 recombinogenic deletions, author applied RFLP method to identify which DAZ gene doublet deletion was involved.


RESULTS
The gr/gr and b2/b3 were two types of common deletions detected. There were significant differences in the b2/b3 deletion in patients with oligozoospermia and severe oligozoospermia compared to the controls (both P< 0.05). However, there was no difference for the gr/gr deletion between the patients and controls.


CONCLUSION
The results suggested that the b2/b3 deletion might be a risk factor to spermatogenic impairment and might lead to male infertility.