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PREFORMULATION STUDIES ON INGREDIENTS OF SUPPOSITORY BASES

Fatty suppository bases are complex mixtures of triglycerides. In order to study the physico-chemical interactions within s~PPositories, especially interactions between the drug and the excipient, it is desirable initially to simplify the system. This may be achieved by examining binary mixtures of pure monoacid triglycerides to obtain a composition whose characteristics resemble those of commercial bases. An explanation for increases in melting point observed on storage of suppositories is proposed here.