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The history of COPD.

The evolution of knowledge concerning COPD and its components – emphysema, chronic bronchitis, and asthmatic bronchitis – covers 200 years. The stethoscope and spirometer became important early tools in diagnosis and assessment. Spirometry remains the most effective means of identification and assessment of the course of COPD and responses to therapy, and is grossly underused for this purpose. Knowledge of the pathogenesis, course and prognosis, and new approaches to therapy have dramatically improved our understanding of this important clinical entity. Smoking cessation improves the early course of disease. Long-term oxygen improves the length and quality of life in selected patients with hypoxemia. Surgery benefits a select few. Today, COPD is a steadily growing global healthcare problem, with increasing morbidity and mortality. Early identification and prevention, and treatment of emerging stages of disease through smoking cessation and a growing number of bronchoactive drugs promises to change the outcome.


Introduction
Chronic obstructive pulmonary disease is fi nally gaining the attention needed to begin to solve this common problem. It is defi ned as chronic airfl ow obstruction that is progressive and only partly reversible (Pauwels et al 2001;Global Initiative for Chronic Obstructive Lung Disease 2004). COPD includes chronic bronchitis, emphysema, and chronic asthmatic bronchitis (defi ned further below). Today, COPD is the fourth most common cause of death in the USA, and is the only disease state that is rising in morbidity and mortality amongst the top fi ve killers. It resulted in a $32.1 billion loss to the USA economy in direct and indirect costs in 2003, and by 2020 is expected to become the third most common cause of death (NHLBI Data Fact Sheet 2003). Approximately 16 million adult Americans have COPD.
Probably an equal number have asymptomatic or even symptomatic disease but are not diagnosed or treated (Mannino et al 2000). Interest in COPD is a recent development and few know the origins of this interesting disease spectrum. This review offers a glimpse into the rich history in the development of our present understanding of COPD.

Early historical landmarks
Some of the earliest references to the description of emphysema include: Bonet's description of "voluminous lungs" in 1679 (Bonet 1679); Morgagni's (1769) description of 19 cases in which the lungs were "turgid", particularly from air; and Baille's illustrations of the emphysematous lung, thought to be that of Samuel Johnson (Baillie 1789;Bishop 1959).
The beginnings of our clinical understanding of the chronic bronchitis component of COPD can be traced to Badham (1814), who used the word catarrh to refer to the chronic cough and mucus hypersecretion that are cardinal symptoms. He described bronchiolitis and chronic bronchitis as disabling disorders (Badham 1814).

Petty
The emphysema component of disease was beautifully described by Laënnec (1821) in his Treatise of diseases of the chest. Laënnec, a clinician, pathologist, and inventor of the stethoscope, did careful dissections of patients that he had studied during life. He recognized that emphysema lungs were hyperinfl ated and did not empty well (Laënnec 1821).
In his A treatise on the diseases of the chest and on mediate auscultation (1837, p 81) Laënnec wrote on emphysema: The disease which I designate by this title is very little known and has not hitherto been correctly described by any author. I for a long time thought it very uncommon, because I had observed only a few cases of it: but since I have made use of the stethoscope, I have verifi ed its existence as well on the living as the dead subject, and am led to consider it as by no means infrequent. I consider many cases of asthma, usually deemed nervous, as depending on this cause. The chief reason of this affection having been so completely overlooked is, that it is in some sort merely the exaggeration of the natural condition of the viscus.
In this era, smoking was rare, but it is a fact that emphysema may occur in non-smokers, particularly with a familial predisposition or from environmental-provoking factors. Laënnec continued: In opening the chest, it is not unusual to fi nd that the lungs do not collapse, but they fi ll up the cavity completely on each side of the heart. When experienced, this will appear full of air . . . . The bronchus of the trachea are often at the same time a good deal fi lled with mucous fl uid (Laënnec 1821, p 89). Thus Laënnec had described a combination of emphysema and chronic bronchitis.
John Hutchinson invented the spirometer in 1846 (Hutchinson 1846). The spirometer is key to the diagnosis and management of COPD, yet its use is still poorly applied to the diagnosis and management of COPD in most locations in the world today. Hutchinson's instrument only measured vital capacity. It took another 100 years for Tiffeneau to add the concept of timed vital capacity as a measure of airfl ow, for spirometry to become complete as a diagnostic instrument (Tiffeneau and Pinelli 1947).
Osler's Principles and practices of medicine (1916) says little about emphysema. Osler believed emphysema was caused by excessive pressure in the alveoli (Osler 1916), and reference to the spirometer cannot be found in this classic text. In 1912, another author did not mention spirometry, but shows a nice picture of the sphygmomanometer, invented by Rico Rossi in 1896, and excellent quality EKG strips are shown (Bovard 1912). This occured 50 years after Hutchinson's invention. A textbook of Disease in the chest in 1918 makes only brief mention of spirometry with no illustrations (Norris and Landis 1918).
Gaensler introduced the concept of the air velocity index based on Tiffeneau's work and later the forced vital capacity, which is the foundation of the FEV 1 and FEV 1 /FVC percent (Gaensler 1950(Gaensler , 1951. In 1944, one of the great teachers of emphysema, Ronald Christie, suggested that "The diagnosis should be considered certain when dyspnea on exertion, of insidious onset, not due to bronchospasm, or left ventricular failure, appears in a patient who has some physical signs of emphysema together with chronic bronchitis and asthma" (Christie 1944, p 145). It is clear from this statement that Christie recognized the individual components of COPD and relied on the history and physical examination for his diagnosis. Oswald described the clinical features of 1000 cases of chronic bronchitis in 1953 (Oswald et al 1953). Barach and Bickerman (1956) edited the fi rst comprehensive text book, Pulmonary emphysema, which nicely describes the treatment of the era. These two physicians were early champions of treatment for emphysema. Contributors to this book included Dayman, the fi rst to recognize the spirometric and fl ow volume patterns indicative of dynamic expiratory airway collapse in emphysema; Dickerson Richards, Nobel Laureate, who wrote on the pulmonary circulation and cor pulmonale; Reuben Cherniack, who described respiratory acidosis and has made major contributions to our understanding of the diagnosis and treatment of emphysema for over half a century; and Menelee and Callaway, who described pulmonary function tests in emphysema patients. In all, 17 leading clinicians and clinical scientists contributed to this classic volume of the 1950s.
The fi rst edition of Hinshaw and Garland (1956) (now Murray and Nadel) Textbook of respiratory medicine shows a nice picture of a Collins 13.5 liter recording spirometer, and shows capacity spirograms that demonstrate airfl ow limitation in emphysema.

Defi nitions
Two landmark meetings: The CIBA Guest Symposium in 1959(Ciba Guest Symposium 1959Donald 1971) and the American Thoracic Society Committee on Diagnostic Standards in 1962 defi ned the components of COPD, which are the foundation for our defi nitions today (Committee on Diagnostic Standards for Nontuberculous Respiratory Diseases 1962). The American Thoracic Society (ATS) defi ned chronic bronchitis in clinical terms including chronic cough lasting at least three months for at least two years. By contrast, the ATS defi ned emphysema in anatomic terms of enlarged alveolar spaces and loss of alveolar walls. Neither defi nition used any physiologic criteria. Asthma was described as a state of airway hyperresponsiveness to a variety of stimuli. Asthmatic bronchitis was considered an overlapping condition (Committee on Diagnostic Standards for Nontuberculous Respiratory Diseases 1962). (The author had the privilege of attending the deliberations of the ATS committee as a Resident in Medicine in 1962 in Memphis Tennessee during the time of the annual VA-Armed Forces Annual Conference on the Treatment of Tuberculosis.) Many other attempts to defi ne COPD have not improved on these basic defi nitions, except that COPD is now defi ned in functional terms.
Other acronyms that predated the COPD designation were chronic obstructive bronchopulmonary disease, chronic airflow obstruction, chronic obstructive lung disease, nonspecifi c chronic pulmonary disease, and diffuse obstructive pulmonary syndrome. William Briscoe is believed to be the fi rst person to use the term COPD in discussion at the 9th Aspen Emphysema Conference. This term became established and today we refer to COPD as the designation of this growing health problem (Briscoe and Nash 1965).

Pathology
In the past 50 years, the pathology of emphysema and other components of COPD have fi lled textbooks (Reid 1967;Heard 1969;Thurlbeck 1976). Loss of alveolar walls (emphysema), mucous gland hyperplasia (Reid index) in large conducting airways (Reid 1960), and bronchiolitis with fi brosis have been extensively documented and illustrated. Thurlbeck's book (1976) cites Jethro Gough and his fi rst use of whole lung thin sections to illustrate the various types of emphysema (Gough 1952;Thurlbeck 1976).
The Dutch hypothesis and British hypothesis in pathogenesis were early basic concepts. The Dutch hypothesis presented the concept of genetically determined bronchial hyperreactivity in COPD (Orie and Sluiter 1960). The British hypothesis proposed that repeated chest infections and air pollution contributed to the pathogenesis of chronic bronchitis (Stuart-Harris et al 1953;Scadding 1959). Both hypotheses are probably correct, and both bronchial hyperreactivity and chest infections plus irritant exposure are important in pathogenesis.

Experimental emphysema
Many disease models have yielded clues to cause, pathophysiology, clinical manifestations, and therapeutic targets. Early attempts to produce experimental emphysema used obstructive devices placed in the major airways or trachea to attempt to reproduce hyperinfl ation. The author spent a research summer employing the use of a venturi device (that had greater expiratory than inspiratory resistance) placed in the trachea of dogs. This study did not produce hyperinfl ation or emphysema. In fact the dogs developed reduced functional residual capacity with the tracheal obstruction, a fact of tracheal obstruction that was not known by this naïve student investigator. A presentation on experimental emphysema at the First Aspen Emphysema Conference in 1958 documents this work and that of earlier investigators (Eiseman et al 1959).
The first credible production of emphysema was by Gross in 1964, who instilled pancreatic extracts (papain) into the airways of guinea pigs to cause destruction of alveoli and hyperinfl ation (Gross et al 1964). This was somewhat of a fortuitous discovery, since he was not trying to produce emphysema, but was hoping to determine the effect of papain on the fi brosis associated with experimental silicosis that he was studying. Gross's work produced emphysema, due to proteolytic damage of elastin and thus was the forerunner of the protease -antiprotease therapy of the pathogenesis, as described by Laurel and Erickson (1963) in Sweden with alpha-one-antitrypsin defi ciency and emphysema. Other investigations also used elastases to produce experimental emphysema (Snider and Sherter 1977). Many genetic, infectious, and immunologic models in small animals followed and continue to be investigated at the present time. A recent model employing methylprednisolone to produce emphysema in rats induces matrix metalloproteinase and can be prevented by a metal proteinase inhibitor (Choe et al 2003). The concept that emphysema is an autoimmune vascular disease has been offered as one pathway in pathogenesis (Voelkel and Taraseviciene-Stewart 2005). Studies in experimental emphysema, though possibly species specifi c, are useful in suggesting new therapeutic targets.

The Aspen emphysema conferences
The growing problem of emphysema and related disorders was the stimulus for a planned series of emphysema conferences held annually in Aspen, Colorado, beginning in 1958 (Mitchell 1959). Roger S Mitchell and his colleagues, Giles F Filley, and John R "Jack" Durrance, were the driving force that launched these landmark conferences. Financial support came from the Department of Medicine of the University of Colorado pulmonary division and local and national tuberculosis associations. The major topics of the fi rst conference included the state-of-the-art understanding of anatomy, pathology, physiology, experimental studies, natural history, unusual forms, and allergy in relation to emphysema. JH McLean's pioneering work on bronchiolitis was and remains a highlight. Liebow described vascular injury including capillary loss in emphysema, and Loosli described loss of elastic fi bers. Pierce discussed lung elastin and collagen, and Brantigan's lung volume reduction surgery was discussed as an innovative method of treating a small number of selected patients with advanced emphysema. Subsequent conferences discussed certain collateral subjects including asthma, the environment, and the lung and pulmonary circulation.
The conferences were intended to conclude after the 1964 meeting. However, the author, now on the junior faculty of the pulmonary division, and his colleagues had a burning desire to have one "last" conference on the treatment of COPD. Somewhat magically, the Chronic Respiratory Disease Branch of the Public Health Service generously supported the 8th Aspen Emphysema Conference. It presented new concepts in the management of acute respiratory failure, home care and rehabilitation, pharmacologic agents in current use, and the new concept of ambulatory oxygen in the treatment of advanced COPD. Surgical resection was again discussed by Brantigan, but now with caution because of high perioperative mortality.
This conference may have been the "tipping point" in the establishment of comprehensive treatment for COPD (Petty 1967). Because of the success of the 8th conference, the 9th, 10th, and 11th conferences were held annually at the same venue. These three conferences dealt with the mushrooming advances in research in COPD during that era. At the 9th conference Ben Burrows and Charles Fletcher presented their concept of "The bronchial and emphysematous types of chronic obstructive lung disease in London and Chicago", pointing out that the same disease spectrum was found on both sides of the Atlantic. This work was also published elsewhere (Burrows et al 1966). Fletcher gave his initial fi ndings on "Prognosis in chronic bronchitis". Subsequent conferences, namely the 12th, 22nd, 26th, and 44th conferences, have documented great progress in our understanding of all aspects of COPD and its treatment. The 48th was the most recent Thomas L Petty Aspen Lung Conference (its present name) to discuss COPD and related disorders, and began with a clinical theme emphasizing the different COPD phenotypes.

Clinical-pathological correlations
Roger S Mitchell and colleagues began a series of studies of the pathology of alveolar and airways damage in patients, participating in an early emphysema registry, who later died and had autopsies at the University of Colorado Medical Center. The focus was mostly on mucous gland hyperplasia and infl ammation of large conducting airways and loss of alveolar walls (Mitchell et al 1966(Mitchell et al , 1968. The lesion of bronchiolitis (small airways) infl ammation was also described by Mitchell et al (1976) in early reports.

Structure/structure-function relations in COPD
Also using an artifi cial thorax to ventilate fresh post-mortem lungs, the Denver Group began a series of systematic studies that were designed to evaluate structure/function relationships and the major lesions associated with COPD, loss of alveolar walls (emphysema), and mucous gland hyperplasia (chronic bronchitis) (Petty et al 1965). By ventilating a whole fresh excised human lung that had been obtained at autopsy, and occasionally was available at the time of donation of organs for transplantation, it was possible to study lung mechanics both from lungs in subjects with no clinical lung disease and in patients with various stages of COPD. The investigators could measure many physiologic indices, including FEV 1 , FVC, maximum mid-expiratory flow, residual volume, and nitrogen washout tests, to study the physiologic expression of lesions of the small airways (Petty et al , 1984(Petty et al , 1987. The measurement of the post-mortem FEV 1 bore a close correlation with the FEV 1 measured during life in the majority of patients (r=0.891), adjusted for both lungs (Petty et al 1965). Progressive grades of emphysema were associated with reductions in FEV 1 . The lesion of mucous gland hyperplasia (ie, the Reid index; Reid 1960) did not have a close correlation with airfl ow measurements.
The history of COPD Dynamic airway collapse of the central airways was related to reductions in FEV 1 .
Accurate smoking histories were available in another series of 154 autopsied patients. Lesions of mucous gland hyperplasia and emphysema were found in nearly 50% of the smokers. Eight non-smokers also had these lesions . Whether or not these patients had other risk factors for the development of the pathologic lesions associated with COPD is not known. This study was performed before the era of understanding the contributions of small airway pathology to airfl ow obstruction.
The landmark study by Hogg et al (1968) ushered in the era of small airways disease. To learn whether or not the nitrogen washout test would identify the lesions of small airways disease, the Denver Group performed additional studies on this and other tests that purported to identify early lesions in patients with COPD with emphysema and on the pathology of small airways (Petty et al , 1984(Petty et al , 1987. Cosio et al (1978) provided his grading photomicrographs of mild, moderate, and severe infl ammation and mild, moderate, and severe fi brosis of small airways. Emphysema was found to relate to a reduction in elastic recoil and in the percentage of the predicted FEV 1 (Silvers et al 1974Petty et al 1984). Elastic recoil was inversely proportional to the closing capacity and the slope of phase III disease . In addition, the maximum expiratory fl ow volume was not related to emphysema (Petty 1984). Fairly good correlations were found among the FEV 1 , FVC, and static lung recoil at 70% of infl ation (Petty et al 1984). Increased lung size (TLC and FR) were related to loss of elastic recoils, but not to airfl ow obstruction (Petty et al 1987).
Numerous key studies initiated by the Montreal group (Cosio, Saetta, Angine, and others) have shown that reduced alveolar attachments, elastic recoil, and alveolar fenestrae are all interrelated and associated with smoking. Reduced elastic recoil is a major factor in the development of airfl ow limitation (Saetta, Shiner, et al 1985;Cosio et al 1986;Saetta 2001).
During the course of these studies, several unusual patients with COPD were encountered, including a 29-year-old man who died of end-stage emphysema and a 19-year-old man who had severe pulmonary hypertension, emphysema, and marked narrowing of the conducting airways of the lungs. The Denver studies also identifi ed the lesion of duct ectasia (ie, an unwinding of alveolar ducts due to loss of elastic recoil) in nonsymptomatic aged individuals .

The natural history of COPD
Charles Fletcher devoted his life to the study of the natural history of COPD (Fletcher et al 1976). He recognized the risks of smoking and the accelerated rate of decline in FEV 1 in susceptible smokers on the pathway to disabling symptoms (Fletcher et al 1976). He and his colleagues recognized that stopping smoking would retard the rate of FEV 1 decline to that approaching the rates of reduction in age-related non-smokers (Peto et al 1983). This established the scientifi c foundation for smoking cessation in every stage of disease (see Lung Health Study) (Anthonisen et al 1994(Anthonisen et al , 2005).
Burrows and Earle described the course and prognosis of 200 patients with COPD in his classic study in Chicago (Burrows and Earle 1969). Later, when observing similar patients in his lifelong study of prognosis of emphysema in a large population in Tucson, Arizona, he recognized that patients with a low FEV 1 /FVC percentage predicted the onset of rapid decline in FEV 1 over time. Patients with the most rapid rate of decline had the worst prognosis. He termed this phenomenon as "The Horse Racing Effect" (Burrows et al 1987). The discovery also established the importance of early identifi cation and intervention (see section titled The NLHEP and GOLD initiatives).
The natural history of COPD begins with complex biochemical and cellular events in the small airways and surrounding alveoli. Early in the course, damage to the structure leads to a loss of elastic recoil (Saetta, Ghezzo, et al 1985;Saetta, Shiner, et al 1985;Petty et al 1987). The lungs begin to increase in size, and the FVC increases (Petty et al 1987). This results in early physiologic alterations that can be readily identifi ed by simple spirometry (Burrows et al 1987). By the time clinical signs are present, COPD is often in a moderateto-advanced stage (Mannino et al 2000).
Pathologic evidence of emphysema can be derived from CT studies or from resectional material, such as when solitary nodules are removed (Cosio et al 1978(Cosio et al , 1986. The most practical way to diagnose and to access the functional progress of COPD is by spirometry. The initial smokinginduced injury to the human lungs appears to be in the small conducting air passages and surrounding alveoli. When alveoli become damaged or lost, the elastic supporting structure of the lung is reduced (Figures 1 and 2). This results in both a loss of elastic recoil and in increased airways Petty resistance since airways are no longer tethered by the radial traction forces of the surrounding alveolar attachments. Mural infl ammation of small airways and airways remodeling also reduce the airway lumen.
Thus, the interrelated causes of airfl ow obstruction in COPD patients include a combination of airways infl ammation and remodeling, bronchospasm, mucous hypersecretion, and loss of elastic recoil. There is a complex interrelationship among these phenomena, which results in the progressive reduction in expiratory airfl ow as judged by the FEV 1 .
It deserves emphasis that early stages of emphysema are characterized by both hyperinfl ation and an increased FVC (Burrows et al 1987;Petty et al 1987). This is the reason why the FEV 1 /FVC ratio is such a sensitive test for early stages of airfl ow obstruction. An FEV 1 /FVC of <70% heralds the onset of rapid declines in FEV 1 over the course of a 10-year period (Burrows et al 1987). The time course of these changes in alveoli and small airways is illustrated in Figure 3. Thirty or more years of progressive loss in airfl ow may take place before the threshold to dyspnea on exertion occurs, which is usually at <1.5 L/s and may be as low as 1.0 L/s in smaller persons.

Treatment of COPD: past, present, and future
Over 47 years ago, when the author graduated from medical school, the only therapies for COPD were antibiotics for pneumonia, potassium iodide used as a mucus thinner, and combination products containing ephedrine, a small amount of theophylline, and a minor amount of sedative to deal with the side effects of ephedrine. Inhaled isoproterenol began to be used in the early 1960s. In that era, oxygen was considered contraindicated, and exercise was prohibited for fear of straining the right heart. Corticosteroids were almost never used, even in cases of exacerbations of COPD. One paper in the early 1960s by Noehren, offered new hope that at least some treatments might be benefi cial in emphysema. Both medical and surgical approaches to therapy were described (Noehren 1962).

Management of acute respiratory failure
Beginning in the early 1960s, patients with COPD began to be saved with the use of mechanical ventilators for the management of acute respiratory failure (Petty 1971). The development of systematic therapy for nonhospitalized patients can be traced to the 8th Aspen Emphysema Conference, which was held in June 1965 (Petty 1967). This was the only Aspen Emphysema Conference devoted entirely to treatment. The Denver Group presented their fi rst observations on ambulatory oxygen at the conference. The many topics discussed by clinicians and scientists at the conference included principles of pulmonary rehabilitation, the treatment of cor pulmonale, home care for chronic pulmonary insuffi ciency, and surgical treatments for emphysema. The subsequent 22nd, 26th, and 42nd Aspen Lung Conferences also had COPD as their theme.

Long-term oxygen therapy (LTOT)
In the fi rst Denver studies of ambulatory oxygen, patients with chronic stable hypoxemia experienced remarkable Together, these two studies established the scientifi c basis of long-term oxygen therapy, which is the only treatment that has been proven to alter the course of disease and prognosis of patients with advanced COPD (Petty 1990).

Pulmonary rehabilitation
Pulmonary rehabilitation evolved from that earlier era (Petty et al 1969;Petty 1993). The systematic use of drugs to restore pulmonary function, including bronchoactive drugs (ie, bronchodilators and corticosteroids) began to gain popularity in the 1990s. An emphasis on the importance of smoking cessation became a feature of treatment in the 1990s.

Surgery
The technique of Lung Volume Reduction Surgery (LVRS), originally introduced by Brantigan and Mueller (1957) and was resurrected by Cooper and others in the 1990s (Cooper et al 1996). A randomized controlled clinical trial completed in 2003 showed no reduction in mortality but an improved quality of life in a subset of surgical patients (National Emphysema Treatment Trial Group 2003). A subset of patients with primarily upper lobe disease and poor exercise tolerance following pulmonary rehabilitation did have a small but signifi cant survival benefi t (National Emphysema Treatment Trial Group 2003).
Lung transplantation is established for a small number of patients, due to the lack of organ availability (Studer et al 2004). Long-term survival for lung transplantation is limited by a high index of organ rejection and bronchiolitis obliterans (Studer et al 2004).

Corticosteroids and bronchodilators
Five studies (Paggiaro et al 1998;Pauwels et al 1999;Vestbo et al 1999;Burge et al 2000;The Lung Health Study Research Group 2000), which were conducted in the 1990s on therapy with inhaled corticosteroids have resulted in interesting and somewhat confl icting conclusions. Although a small subset of patients has a slight step-up in FEV 1 following the administration of inhaled corticosteroids, the rate of decline in FEV 1 was not retarded in any of the studies completed thus far. However, symptoms of cough, expectoration, and exacerbations of chronic bronchitis were signifi cantly reduced in patients in the treatment groups compared with those in the placebo group. Symptomatic benefi ts need to be weighed against the possibility of systemic side effects (eg, reduced bone density) if inhaled corticosteroids are to be used in the long term (The Lung Health Study Research Group 2000). Improved survival in COPD using a combination of fl uticasone propionate and salmeterol has been suggested in case controlled studies (Soriano et al 2002;Sin and Man 2003). Prospective randomized controlled studies are currently in progress to attempt to confi rm these fi ndings.

COPD as a systemic disease
It has been learned that patients with only mild stages of COPD may have signifi cant cardiovascular physiologic impairments. These individuals cannot achieve maximum oxygen uptake or a maximum heart rate. Their exercise performance is limited and is likely due to physical deconditioning, even in patients with only mild degrees of airfl ow obstruction and without hypoxemia (Carter et al 1993). We must now recognize COPD as a systemic disease and start to understand the metabolic and musculoskeletal implications of this generalized process (Schols et al 1996(Schols et al , 1998. COPD has been recognized as a risk factor for cardiovascular morbidity and mortality (Sin and Man 2005). Thus corticosteroids may (or may not) have a benefi cial role on the underlying systemic nature of COPD. Obviously this is an area that requires intense factor investigation.

Petty
The pathogenesis of pulmonary hypertension in COPD and its treatment also remain a huge challenge (Higgenbottom 2005). We need to learn much more about the molecular genetics of COPD (Sanford et al 1997). Why do only 15%-20% of smokers develop airfl ow obstruction (Sanford et al 1997)?

The Lung Health Study
Following a preliminary meeting organized by the author in 1982 during his presidency of the American College of Chest Physicians and attended by many experts who were both for or against studies of early identifi cation, the Lung Health Study was planned and implemented by the Lung Division of the National Heart, Lung, and Blood Institute (NHLBI). In all 10 centers, 5887 volunteers were enrolled who were heavy smokers between the ages of 35 and 60, and who had any degree of airfl ow obstruction identifi ed at baseline screening (Anthonisen et al 1994). Subjects were randomized to receive special care or usual care in a 2:1 ratio. Half of the subjects randomized to special care received ipratropium bromide and the other half an identical placebo inhaler. The initial report of outcome showed that 22% of patients who received special care stopped smoking as part of the study, compared with 5% in the usual care group. Patients who succeeded in stopping had a small improvement in FEV 1 initially, followed by a slow decline up to fi ve years of follow-up (Figure 4). Ipratropium did not improve baseline lung function, but did increase airfl ow on each day that it was tested over the course of the study.
The most common cause of death was lung cancer (57), compared with 37 cardiac deaths and 55 deaths from all other cancers (N=149). At a 14.5-year follow-up, the most common cause of death remained lung cancer (33%), with cardiovascular deaths the second most common cause of death (22%). Coronary artery disease was also a common cause of death but the death records had an overlap with the designation of cardiovascular deaths. Seven point 8 percent (7.8%) died of nonmalignant respiratory disease. Two point three percent (2.3%) died of unknown causes. This powerful study showed conclusively that stopping smoking in middle age (Anthonisen et al 2005) was associated with a much better survival than in patients who continued to smoke. This study and others form the scientifi c basis for early identifi cation of COPD and related disorders, the most common of which is lung cancer.

The NLHEP and GOLD initiatives
Following a preliminary planning meeting in 1993 and a comprehensive workshop on COPD sponsored by the Lung Division of the NHLBI, the need for a new national health initiative for the early diagnosis, treatment, and research in COPD was launched in a major publication (Petty and Weinmann 1997) and later on gained full support in CHEST (Petty 1998). Soon thereafter, the National Lung Health Education Program (NLHEP) was founded by the author, who was its fi rst chairman. Initial NIH support was supplemented by unrestricted grants from the pharmaceutical industry. All major societies with a stake in COPD sent representatives to the biennial board of directors meeting held at the times of the American College of Chest Physicians and ATS. Numerous publications and recommendations followed. The most notable was the consensus's statement of the NLHEP, which recommended the spirometric testing of all smokers aged 45 or older and anyone with chronic cough, dyspnea on exertion, mucus hypersecretion, or wheeze (Ferguson et al 2000). This helped promote the development of accurate and inexpensive offi ce spirometers for widespread use. In 2004, the NLHEP's administrative functions were  . International in scope, GOLD offered a new classifi cation of the severity of COPD, which is now accepted by most societies and organizations. Together, the NLHEP and GOLD will continue to raise awareness of the importance of COPD and promote early identifi cation and intervention.

Recent biologic studies and therapeutic targets
The pathogenesis of COPD is complex and involves multiple mechanisms. The bottom line of these processes is infl ammatory damage of the conducting airways and vascular damage of the alveolar surface of the lung, which constitutes the air-blood interface. Capillary damage leads to loss of both alveolar walls and reduced elastic recoil. Infl ammatory obstruction of small airways contributes to airfl ow obstruction; the loss of alveolar walls and airfl ow obstruction (as Laënnec fi rst described) are part and parcel of the pathogenesis.
The inflammatory process of COPD is initiated by inhalation of noxious gases in cigarette smoke and in the environment. All airways, including the central airways, become infl amed, which results in mucous gland hyperplasia and hypersecretion. Macrophages and CD8 cells are the prime cellular mediators, which include leukotriene B 4 , interleukin-8, and tumor necrosis factor (TNF) (Barnes 2000). Thus, the inflammatory processes of COPD are markedly different from those of asthma. Infl ammation in asthma consists of more corticosteroid-responsive cells and mediators, such as mast cell-activated eosinophils, T-helper type 2 lymphocytes (CD4 phenotype), and a number of cytokines whose production is decreased by use of corticosteroids. This may explain, at least in part, why patients with COPD are not nearly as responsive as patients with asthma to both inhaled and systemic steroids.
The protease-antiprotease imbalance is certainly true in the alpha-1-antitrypsin defi ciency state. Matrix metalloproteinases, collagenases, and other tissue-degrading enzymes are released from macrophages and neutrophils.
An oxidant-antioxidant imbalance also exists in small airways and at the air-blood interface. How this can be dealt with therapeutically remains a challenge. Potentially, many other mechanisms (including processes that trigger mucus hypersecretion or cause dysfunction) and inhibition of growth factors (such as vascular endothelial growth factor at a reduced level) result in premature apoptosis of capillaries and the alveolar walls they nourish (Kasahara 2001). Phosphodiester 4 inhibitors are a new class of drugs that may oppose or otherwise modify the basic infl ammatory processes of the small and large airways. Specifi c cytokine antagonists (eg, 1, 2, and 3) on TNF2 inhibitors are the subject of current investigations (Barnes 2000). Systemic clinical approaches to patients with COPD and cardiovascular disease are emerging (Soriano et al 2002;Rennard 2005;Sin and Man 2005). All of this new knowledge about the pathogenesis of emphysema and related airway infl ammation promises new therapeutic targets for the future.

Summary
The evolution of our understanding of emphysema and chronic bronchitis covers nearly four centuries. Anatomists, clinical scientists from many disciplines, and clinicians have contributed to the knowledge that an attack on alveoli and both large and small airways contribute to the emergence of chronic and ultimately irreversible airfl ow limitation, due to loss of elastic recoil and increase in airfl ow resistance through the complex conducting system of the lungs.
Dyspnea is due primarily to abnormal lung and thoracic mechanics and the increased work of breathing. Cough and mucus hypersecretion are due to infl ammation, mucous gland hyperplasia, and goblet cell hyperplasia. One or more host factors are involved in many patients, and family clustering may go beyond alpha-one-antitrypsin defi ciency. COPD must be considered a systemic disease.
Treatment requires an elimination of smoking and other irritants in the environment. Such measures forestall or prevent the premature loss of ventilatory function and loss of blood gas homeostasis.
Treatment of symptomatic disease, beyond smoking cessation requires the use of bronchodilators and probably corticosteroids. Pulmonary rehabilitation and oxygen improve the quality and length of life in selected patients. Lung volume reduction surgery improves lung mechanics and reduces dyspnea by improving elastic recoil, which affects both airfl ow and perfusion, thus ameliorating gas exchange abnormalities in selected patients. Lung transplantation helps a few patients.
The future requires early identifi cation and intervention in the basic disease processes. Spirometry must emerge as the fundamental way to diagnose and monitor responses to therapy. It must be employed by all who care for patients with COPD. New therapies must reduce both alveolar damage and infl ammation of the airways. The future for COPD science and improved prevention and patient care appears bright.