{'fraction_non_alphanumeric': 0.039000609384521635, 'fraction_numerical': 0.039609993906154786, 'mean_word_length': 4.949275362318841, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Phenindione sensitivity with leukaemoid reaction and hepato-renal damage.

SOULIER & GUEGUEN, who first introduced phenindione as a therapeutic agent, were also the first to record sensitivity to the drug (Soulier & Gueguen, 1947). Perkins (1962a) reviewed 132 cases of sensitivity reaction of which six had been fatal. Since this time further severe reactions have been reported with a significant number of fatalities. The incidence of toxic reactions is variously reported. Perkins found an incidence of 5%. Other estimates have varied from as low as 0-1% (Ager & Ingram, 1957) to as high as 10-7%/ (Stafford, 1961), and in a recent trial of short term anticoagulants (Report to Medical Research Council, 1969) sixteen of 712 patients on full therapeutic dosage of phenindione showed definite or possible sensitivity reactions, an incidence of 2-25% within a period of 28 days. It is of interest that none of the patients on the control low-dosage regimen showed toxic signs, and there seems to be a relationship between higher dosages and toxic reactions, perhaps favouring the view that some of the adverse effects of phenindione are the direct result of a potentially toxic modified benzene ring in the compound (Burns & Desmond, 1958). From time to time pleas have appeared for the abandonment of phenindione in favour of the coumarin derivatives (Brown & McMillan, 1954; Tait, 1960; Shapiro, 1962; Hollman & Wong, 1964; Davies, 1965; British Medical Journal, 1969). Nevertheless it remains a popular anticoagulant in this country, and in reporting this severe sensitivity reaction, it is hoped to draw attention again to its hazards.