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PATHOLOGICAL STUDY ON AMYLOIDOSIS

The formation of amyloid in adjuvant granuloma induced in AKR and C3H/He mice by intraperitoneal single injection of complete Freund's adjuvant mixed with Mycobacterium butyricum was studied by electron microscope. Amyloid appeared in close association with macrophages in the adjuvant Qranuloma at first. These macrophages were characterized by well‐developed Golgi apparatus, several proAles of granular endoplasmic reticulum and free ribosomes. Membrane‐limited inclusions with Abrillar structure were prominent in their cytoplasms in the vicinity of the well‐oriented amyloid fibrils. These inclusions might have an intimate relation with amyloid formation. The author suggests that macrophages, one of the cellular components of adjuvant granuloma are the most likely candidate for amyloid producer.