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HUMAN MILK BANKING. II. RELATIVE STABILITY OF IMMUNOLOGIC FACTORS IN STORED COLOSTRUM

It has been suggested that human colostrum and milk may provide nutritional and immunologic advantages for the low birth weight as well as term born infant. We have, therefore, begun to examine the demographic variables and storage conditions which might affect the quality of banked human lactation products. In our first report (1) we found that storage of mature milk at 4°C for 24 hours in polypropylene containers caused a significant decrease in lysozyme and lactoferrin, whereas polyethylene containers dramatically reduced the titer of secretory IgA (SIgA) antibodies to E. coli somatic antigens without decreasing the concentration of total or secretory IgA. The number of macrophages, neutrophils, and lymphocytes in the fluid phase of milk in polypropylene, polyethylene and pyrex glass containers increased as much as ten-fold between 4 and 24 hours of storage. However, the functional activity of these cells, as indicated by the mitogen responses of lymphocytes and the adherence of macrophages and neutrophils, was reduced after storage. This suggested that the increase in the numbers of cells during storage at 4°C was due to release of metabolically damaged cells from the container surfaces. The purpose of the present study was to examine the effect of the type of storage containers and the time of storage on the immunologic factors in human colostrum.