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Veterans with PTSD see no benefit from prazosin for sleep outcomes

Military veterans with post‐traumatic stress disorder (PTSD) and frequent nightmares saw no significant benefit in sleep‐related outcomes from use of the alpha‐adrenergic antagonist prazosin, a placebo‐controlled study has found. The results of this trial contradict those of earlier studies of prazosin that suggested benefits in reducing PTSD symptoms and improving sleep quality. Study results were published Feb. 8 in the New England Journal of Medicine.