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The effect of cyclosporine, rapamycin and FK 506 the survival following allogeneic bone marrow transplantation.

We have previously reported that treatment with FK 506 and cyclosporine (CyA) are effective in reversing established acute graft-versus-host disease (GVHD) in an allogeneic rat model.1 In clinical bone marrow transplantation, however, recovery from GVHD has not necessarily been associated with prolongation of survival.2,3 Therefore, we were interested in comparing the immunosuppressive agents, CyA, rapamycin (RPM), and FK 506, in respect to survival after allogeneic bone marrow and spleen cell transplantation (BMSPTX).