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MODULATION OF HERPESVIRUS HOMINIS INFECTION IN NEWBORNS BY MATERNALLY TRANSFERRED ANTIBODIES

The protective role of maternally transferred antibodies on resistance to H. hominis infection was examined by epidemiologic survey of 211 human sera for antibodies and by experimental infection in newborn mice.Twenty five cord blood and 186 sera from persons of varying ages were tested for antibodies against H. hominis by indirect immunofluorescent staining method. The antibody reached the highest levels in the cord blood (mean titers = 1:1477) and the lowest levels between 6 months and one year of age (mean titers= 1:156). The antibody approached the adult levels (mean titers = 1:1193) by the age of 17 years. The apparent inverse relationship between the antibody levels in the population and the incidence of the disease indirectly suggests the protective role of the antibodies.Exogenous administration of antibodies directed against H. hominis to pregnant mice resulted in an enhanced resistance to H. hominis infection in the offsprings. The mortality was 75% for the controls (35 mice) and 15% (P < 0.005) for the offsprings (39 mice) of mothers receiving antibodies.These data suggest that maternally transferred antibodies play a significant role in modulating the pathogenesis of H. hominis infection in the newborn.