{'fraction_non_alphanumeric': 0.024696707105719237, 'fraction_numerical': 0.010051993067590987, 'mean_word_length': 5.1552, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 2, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 1, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Acute guttate psoriasis and psoriatic arthritis simultaneously in a 33-year-old male with streptococcal infection

Psoriasis is a chronic, inflammatory, immune-mediated skin disease. There are several clinical phenotypes at disease onset, such as guttate, plaque, erythrodermic, pustular phenotypes and psoriatic arthritis. In this report, we describe a 33-year-old Chinese male diagnosed with acute guttate psoriasis who had concurrent psoriatic arthritis. The patient had non-pruritic erythematous guttate scaly papules on his trunk and proximal extremities for two weeks and swelling and pain in the fourth metacarpophalangeal joint of the right hand for four weeks on admission. A diagnosis of guttate psoriasis was quickly made according to the typical eruptions and positive Auspitz sign. And then joint ultrasound revealed that there was tenosynovitis in the fourth metacarpophalangeal joint of the right hand, consistent with the performance of psoriatic arthritis. So a diagnosis of psoriatic arthritis was also made according to the ultrasonic results and a history of psoriasis. At last, the patient had a history of the chronic tonsillitis and antistreptolysin O titer was 797.1 IU/ml at admission. Streptococcal infection was considered as the major causative factor for this patient with guttate psoriasis and psoriatic arthritis, although this was a rare report of acute guttate psoriasis and arthritis psoriasis simultaneously appeared in a patient after the chronic tonsillitis attacked. (This page in not part of the published article.) International Journal of Case Reports and Images, Vol. 8 No. 12, December 2017. ISSN: 0976-3198 Int J Case Rep Images 2017;8(12):796–799. www.ijcasereportsandimages.com Zheng et al. 796 CASE REPORT PEER REVIEWED | OPEN ACCESS Acute guttate psoriasis and psoriatic arthritis simultaneously in a 33-year-old male with streptococcal infection Jianfeng Zheng, Yangfeng Ding


INTRODUCTION
Psoriasis is a chronic, proliferative, and inflammatory skin disease, characterized by increased propagation of epidermis with dermal capillaries dilation. There are various types of psoriasis identified by clinical outcomes. Psoriasis is often first detected between the age of 15 and 25 years, and psoriasis arthritis usually develops between the age of 30-50 years. Guttate psoriasis is a type of psoriasis in which erythematous guttate scaly papules appear all over the body [1]. Among these patients, 56-100% has recent precedent evidence of streptococcal disease such as the tonsillitis [2]. Psoriasis arthritis is a type of psoriasis in which joints become red, swollen, tender, warm, and stiff under the infiltration of inflammation. Its causative agents include trauma, allergies of medicines, alcohol consumption, skin irritants, and smoking [3]. Here, we present a case of acute guttate psoriasis and arthritis psoriasis simultaneously appeared in a 33-year-old male with a 15-year history of plaque psoriasis after the chronic tonsillitis attacked.

CASE REPORT
A 33-year-old male presented with one-month history of swelling and tender in the fourth metacarpophalangeal joint of the right hand and a two-week history of nonpruritic erythematous guttate scaly papules on his trunk and extremities. He denied any recent travel, drugs or medications, environmental changes. However, the patient stated that there was a sore throat, swollen tonsils, fever, congestion, malaise, and fatigue about one month and a half before admission to our hospital and a 20-year history of the chronic tonsillitis. These symptoms were not actively treated because of his busy job. The fourth metacarpophalangeal joint of the right hand suddenly become red, swollen, tender about one month before admission. But the patient did not go to hospital in time. And then some round, erythematous, hyperkeratotic, flat papules with adherent scale began appearing on his trunk about two weeks before admission and had spread to his extremities on the day that he was admitted. He also reported a personal history of chronic plaque psoriasis over 15 years ago which, when the chronic tonsillitis attacked, would relapse. In the last six months, there were only few patches on his extension side of bilateral calves under conditions of actively treatment of psoriasis and preventing the recurrence of tonsillitis.
On physical examination, the author noted 1-10 mm round, erythematous, hyperkeratotic, flat papules with adherent scale on his trunk and bilateral upper extremities and thighs, Auspitz sign (+). Patches on his extension side of bilateral calves and mildly swollen in the fourth metacarpophalangeal joint of the right hand were checked simultaneously, tenderness (+). His mucous membranes, however, were not involved. In addition, there was moderate swelling on the tonsil ( Figure 1).

DISCUSSION
Fehleisen first isolated β-hemolytic streptococci in 1883. Lancefield's classification of β-hemolytic streptococci according to their carbohydrate surface antigens has revealed that group A β-hemolytic streptococci are the most pathogenic to humans [4]. And it was not until 1916 that the association streptococcal tonsillitis and guttate psoriasis was first reported [5]. Much work has involved monitoring titres of antibodies to the streptolysin O exotoxin (ASO titres) as these provide an indication of recent streptococcal infection.
In 1952, Norholm-Pedersen divided a group of 133 unselected patients with psoriasis into three groups depending on their ASO titres and found the highest proportion of patients with guttate psoriasis in the highest ASO group [6]. The close relationship between guttate psoriasis and streptococcal infection has lead some investigators to examine a possible role for infectious agents in the pathogenesis of psoriasis arthritis. The presence of streptococcal antigens has not been demonstrated in the joints of psoriasis arthritis patients. Therefore, it is difficult to prove a pathogenic role for such antigens, as secondary infection of psoriatic plaques is common. Some reports have suggested that HIV and hepatitis C virus may play a more significant role in the pathogenesis of psoriasis arthritis [7,8]. Both of acute guttate psoriasis and psoriatic arthritis are the common phenotypes of psoriasis. But they have obviously different characterizes. Rare reports had revealed that the patients with arthritis were found among the non-guttate patients [9]. In this case, there is no direct evidence to support a role for such antigens in the pathogenesis of psoriasis arthritis. However, there is a distinct tendency for improvement in the symptoms of arthritis after treatment of the tonsillitis.
In an earlier paper, it was described how acute eruption of psoriasis may be produced in phases of immune deficiency and in the presence of bacterial antigenreleasing inflammatory foci, whereas clinical spontaneous remissions are produced in phases of immunologic activity. In this case, the patient had significantly elevated antistreptolysin titer, as well as proliferative responses to streptococcal antigens. But serum immunoglobulin levels (IgM, IgG, IgA) was in normal range. It revealed that our patient was clinically active with eruptions. Furthermore, there is a rise in CD4+ cells and a reduction in CD8+ and natural killer cells in our report, CD4+/ CD8+ ratio was considerably increased. Systemic defense essentially depends on the activity of CD8+ and natural killer cells. Animal experiments have shown that natural killer cells play a decisive role in the response to microbial infections as part of nonspecific cellular defense [10]. These results are consistent with immune deficiency. So the dermatosis has been regarded as a T cell mediated autoimmune disease.

CONCLUSION
In this case, we present a rare case of acute guttate psoriasis and psoriasis arthritis simultaneously appeared in a patient with a 20-year history of the chronic tonsillitis. The typical eruptions, the ultrasonic results and a history of psoriasis were helpful to make this diagnosis. Clinicians should be aware of a certain relationship between psoriasis arthritis and streptococcal infection and make more examinations to discover the pathogenesis of psoriasis. *********

Author Contributions
Jianfeng Zheng -Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Yangfeng Ding -Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published

Guarantor of Submission
The corresponding author is the guarantor of submission.

OPEN ACCESS
Edorium Journals: On Web

About Edorium Journals
Edorium Journals is a publisher of international, highquality, open access, scholarly journals covering subjects in basic sciences and clinical specialties and subspecialties.

Edorium Journals: An introduction
Why should you publish with Edorium Journals?
In less than 10 words: "We give you what no one does".

Vision of being the best
We have the vision of making our journals the best and the most authoritative journals in their respective specialties. We are working towards this goal every day.

Exceptional services
We care for you, your work and your time. Our efficient, personalized and courteous services are a testimony to this.

Editorial review
All manuscripts submitted to Edorium Journals undergo pre-processing review followed by multiple rounds of stringent editorial reviews.

Peer review
All manuscripts submitted to Edorium Journals undergo anonymous, double-blind, external peer review.

Early view version
Early View version of your manuscript will be published in the journal within 72 hours of final acceptance.

Manuscript status
From submission to publication of your article you will get regular updates about status of your manuscripts.

Favored author program
One email is all it takes to become our favored author. You will not only get 15% off on all manuscript but also get information and insights about scholarly publishing.

Institutional membership program
Join our Institutional Memberships program and help scholars from your institute make their research accessible to all and save thousands of dollars in publication fees.

Our presence
We have high quality, attractive and easy to read publication format. Our websites are very user friendly and enable you to use the services easily with no hassle.

Something more...
We request you to have a look at our website to know more about us and our services. Please visit: www.edoriumjournals.com We welcome you to interact with us, share with us, join us and of course publish with us.

Invitation for article submission
We sincerely invite you to submit your valuable research for publication to Edorium Journals.

Six weeks
We give you our commitment that you will get first decision on your manuscript within six weeks (42 days) of submission. If we fail to honor this commitment by even one day, we will give you a 75% Discount Voucher for your next manuscript.

Four weeks
We give you our commitment that after we receive your page proofs, your manuscript will be published in the journal within 14 days (2 weeks). If we fail to honor this commitment by even one day, we will give you a 75% Discount Voucher for your next manuscript.