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[Characterization of urinary macromolecular inhibitors of calcium oxalate crystal aggregation].

Recently we have reported that the urinary macromolecular inhibitors may play an important role in the prevention of in vivo stone formation and that in the urine of recurrent stone formers the urinary macromolecular inhibitory activity was decreased significantly. Then we made further studies to characterize the macromolecular inhibitors. They seemed to be composed of unknown proteins or protein-complexes since approximately 70 to 90 per cent of the macromolecular inhibitory activity was destroyed by protein digestion with proteinase. And, based on the result of Sephacryl S-300 gel filtration, it was speculated that they were not simple proteins but protein-complexes. On the other hand, we could demonstrate that urinary acid glycosaminoglycans, which have been considered to be a possible inhibitor, play a minor role in the inhibition of crystal aggregation and the inhibitory activity originating in the urinary acid glycosaminoglycans of recurrent stone formers was not decreased significantly from the normal level. And we could show that RNA-like substances, which have also been reported as possible inhibitors, did not contribute to the urinary macromolecular inhibitory activity demonstrated in our recent study.