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Effects of various mu- and delta-opioid ligands on food intake in the meat-type chick.

The present study was designed to examine the effects of mu- and delta-opioid receptor ligands on feeding behavior in meat-type chicks. Intracerebroventricular (ICV) injection of naltrexone (mu- and delta-antagonist), beta-funaltrexamine (beta-FNA; mu-antagonist), ICI-174,864 (ICI; delta-antagonist), or naloxonazine (NAL; mu1-antagonist) significantly decreased deprivation-induced feeding at 30 min postinjection. Co-injection of beta-FNA, but not NAL, significantly blocked the depressive effect of [D-Ala2, N-MePhe4, Gly5-ol]-enkephalin (mu-opioid agonist) under ad libitum conditions. Central injection of ICI attenuated significant effects of [D-Pen(2,5)]-enkephalin (delta-opioid agonist) on feeding behavior in ad libitum fed chicks. Co-injection of beta-FNA, but not ICI, significantly attenuated the orexigenic effect of [D-Ala2, D-Leu3]-enkephalin (mu- and delta-opioid agonist). These results suggest that the endogenous opioid peptides, which act on the mu- and/or delta-opioid receptor, have an important role in feeding behavior in the central nervous system of meat-type chicks.