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Antibiotic Use After Removal of Penicillin Allergy Label

D Vyles, A Chiu, J Routes. Pediatrics. 2018;141(5):e20173466

To evaluate the clinical and economic impact of negative penicillin testing results for children with a previous penicillin allergy label.

This study included caregivers and primary care providers (PCPs) of 100 children between the ages of 4 and 18 years with negative test results for penicillin allergy after percutaneous, intracutaneous testing and an oral challenge.

A follow-up case series investigation was performed on 100 children with “low-risk” allergy symptoms who had a negative penicillin allergy evaluation result. Low-risk symptoms included a nonurticarial rash, itching, diarrhea, and vomiting. The study authors hypothesized that no serious allergic reactions would occur with reexposure and that prescribing practices would change as a result of testing. A brief telephone survey was administered to parents and PCPs. Parents were questioned regarding antibiotic use since penicillin testing, any recent allergic reactions, parental comfort level with future penicillin use, …