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MP19-19 INFLUENCING FACTORS OF POSTOPERATIVE RENAL FUNCTION IN RENAL CELL CARCINOMA WITH TUMOR THROMBUS: A LARGE CHINESE CENTER EXPERIENCE

INTRODUCTION AND OBJECTIVES: To explore the influencing factors of postoperative renal function in patients with renal cell carcinoma (RCC) with tumor thrombus in a large Chinese center. METHODS: The clinicopathological data of 135 patients with RCC with tumor thrombus, who underwent radical nephrectomy and inferior vena cava thrombectomy at Peking University Third Hospital from May 2015 to July 2018, was retrospectively analyzed. Absolute change in estimated glomerular filtration rate (eGFR) (ACE) was calculated and ACE = eGFRpostoperative-eGFRpreoperative. RESULTS: Of all the 135 patients,in multivariate linear regression analysis, preoperative eGFR (P<0.001), pathological type (P=0.007), lymph node metastasis (P=0.005), distant metastasis (P=0.031) and postoperative complications (P=0.005) were significant predictive factors of ACE. In multivariate analysis, preoperative eGFR (P<0.001), operation approach (P=0.021), sarcomatoid differentiation (P=0.027) and postoperative complications (P=0.028) were risk factors of predicting worse postoperative renal function. According to receiver operating characteristic (ROC) curve analysis, the cut off value of ACE was 13.9 and ACE>13.9 indicated the worse CSS (P= 0.038). CONCLUSIONS: We explored several clinicopathological risk factors of predicting postoperative renal function in a large center. The ACE was prognostic risk factors for CSS in RCC with tumor thrombus patients and ACE>13.9 indicated the worse prognosis. Figure. No caption available. Source of Funding: none.