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The Effect of Aging on the Degree of Association Between the Thyroid Hormones and the Outcomes of Ischemic Stroke: A Restrospective Study


 BackgroundAcute Ischemic Stroke is a leading cause of death worldwide. Many clinical studies have focused on the correlation between thyroid axis hormones and disease outcomes, but results remain controversial. One possible reason for the conflicting results is that the association among prognostic factors varies in different age groups. our study is focused on the effect of aging on the association and the degree of correlation between thyroid-related hormones and ischemic stroke outcomes. MethodsThe retrospective study was performed on 1025 stroke patient records. Included patients were in three age groups: Above 85 Group, 65-80 Group, and Below 65 Group. Spearman’s rank correlation was performed to evaluate the association and the degree of correlation between thyroid hormones and the NIHSS score. ResultsA total of 604 patients meeting study criteria were included in the study. Excluding reasons were previous stroke, thyroid-related diseases, cancer, chronic liver diseases, and other reasons. T3 was found to be significantly associated with NIHSS score except in the Below 65 Group. fT3 was inversely related to the NIHSS in all age groups. TSH had similar association except in the Above 80 Year Group. T4 and fT4 didn’t have significant association with disease severity, except in the 65-80 Year group for fT4. ConclusionsAging had a significant effect on the association and the magnitude of correlation between thyroid hormones and stroke outcomes. The more delicate age-dependent grouping methods could provide more accurate and clinically meaningful insights into the prognostic values of biomarkers.