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Hydration of arene and alkene oxides by epoxide hydrase in human liver microsomes

The comparative hydration of styrene 7,8‐oxide, octene 1,2‐oxide, naphthalene 1,2‐oxide, phenanthrene 9,10‐oxide, benzo[a]anthracene 5,6‐oxide, 3‐methylcholanthrene 11,12‐oxide, dibenzo[a,h]anthracene 5,6‐oxide, and benzo[a]pyrene 4,5‐, 7,8‐, 9,10‐, and 11,12‐oxides to their respective dihydrodiols was investigated in microsomes from nine human autopsy livers. The substrate specificity of the epoxide hydrase in human liver microsomes was very similar to that of the epoxide hydrase in rat liver microsomes. Phenanthrene 9,10‐oxide was the best substrate for the human and rat epoxide hydra ses and dibenzo[a,h]anthracene 5,6‐oxide and benzo[a]pyrene 11,12‐oxide were the poorest substrates. Plotting epoxide hydrase activity obtained with one substrate against epoxide hydrase activity for another substrate for each of the nine human livers revealed excellent correlations for all combinations of the 11 substrates studied (r = 0.87 to 0.99). The data suggest the presence in human liver of a single epoxide hydra se with broad substrate specificity. However, the results do not exclude the possible presence in human liver of several epoxide hydrases that are under similar regulatory control. These results suggest the need for further investigation to determine whether there is a safe epoxide of a drug whose in vivo metabolism is predictive of the capacity of different individuals to metabolize a wide variety of epoxides of drugs and environmental chemicals.