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Effects of Ethanol Extract of Gastrodia elata Blume on High‐Fructose induced Metabolic syndrome

Metabolic syndrome including insulin resistance, dyslipidemia and hypertension is a cluster of risk factor of cardiovascular disease. Gastrodia elata Blume (EGB), a widely used traditional herbal medicine, was reported with anti‐inflammatory and anti‐diabetes activity. Aim in the present study was to investigate that ethanol extract of EGB ameliorate metabolic signs of 65% high‐fructose diet induced metabolic syndrome. Treatment with EGB (100 mg/kg/day for 8 weeks) was significantly suppressed the increments of epididymal fat weight, blood pressure, plasma triglyceride, leptin and total cholesterol levels. EGB treatment also elevated HDL cholesterol and oral glucose tolerance. Staining with HE and Oil‐red‐O demonstrated marked increase of adipocyte size and hepatic accumulation of triglycerides, and these increases were prevented by EGB. EGB amelorated endothelial dysfunction by down‐regulation of ET‐1 and adhension molecules in the aorta. In addition, EGB suppressed mRNA expression of the cytokines related with hepatic proinflammation. Moreover, EGB induced markedly up‐regulation of AMPKα phosphorylation in the liver, muscle and fat. These results indicate that EGB ameliorates obesity, insulin resistance, dyslipidemia, hypertension and fatty liver in HF diet rats. Take together, Gastrodia elata Blume might be a beneficial therapeutic approach for metabolic syndrome.