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Evidence behind the WHO guidelines: hospital care for children: what is the efficacy of sublingual, oral and intravenous glucose in the treatment of hypoglycaemia?

The World Health Organization has produced guidelines for the management of common illnesses in hospitals with limited resources. This series reviews the scientific evidence behind the WHO's recommendations. The WHO guidelines, and more reviews are available at: http://www.ichrc.org This review addresses the question: What is the efficacy of sublingual, oral and intravenous glucose in the treatment of hypoglycaemia? The WHO Pocketbook of Hospital Care for Children recommends the use of oral glucose (via Nasogastric or orally) in the form of Formula 75 or oral glucose solution (10% glucose/sucrose solution). In the event where the child presents unconscious, intravenous 10% dextrose at a rate of 5 ml kg ―1 is recommended. Recent evidence has, however, suggested the possible inclusion of sublingual glucose into this management guideline.