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The in vivo spleen response to sheep erythrocytes in bursectomized-irradiated chickens.

The proliferative and plaque forming cell (PFC) responses in the spleens of control-irradiated and bursectomized-irradiated chickens 4 days after a single i.v. injection of sheep erythrocytes (SRBC) were studied. Both the proliferative and the PFC response was deficient in the bursectomized-irradiated chickens. The “background” anti-SRBC PFCs found in the spleens of unimmunized control-irradiated chickens were absent in bursectomized-irradiated animals.