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Natural cytotoxic autoantibody against thymocytes in spontaneously hypertensive rats.

Spontaneous hypertensive rats produced a natural thymocytotoxic autoantibody (NTA) which was cytotoxic for the thymocytes of the various strains of rats tested. More than a 60% incidence of NTA in the SHR occurred from 1 month of age and was observed throughout their life span. The titers of the autoantibody varied among individual rats and progressively increased with age. The NTA was cytotoxic for thymocytes but weak or negative for spleen, lymph node and bone marrow cells. However, absorption test indicated that NTA-reactive antigens were distributed in the thymus, spleen, lymph nodes, and brain of adult rats. The NTA in SHR was an IgM-globulin as determined by sensitivity to 2-ME treatment and by Sephadex G-200 column chromatography. These results suggest that the NTA is responsible for the selective suppression of T-cell functions in SHR.