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Cognitive Disturbances and Magnetic Resonance Imaging Findings in Multiple Sclerosis

Twenty patients (mean age ± standard deviation, 42 ± 14 yr) with multiple sclerosis were studied to define a possible relation between cognitive decline and pathology seen on magnetic resonance images (MRis). In all, a battery of psychometric tests and MRis were conducted. MRI results were classified according to cerebral lesions and different ventricle indexes. A rating scale graded the severity of cerebral lesions. MRI and psychometric data from the patients were compared with the results of an age‐ and sex‐matched control group. The results suggest that evidence of cognitive decline shows a stronger relation to substance loss, defined by ventricle indexes, than to the lesion score.