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[The effect of pyridinolcarbamate (parmidine) on the microcirculation and immunity of patients with stable angina].

A comparison of the efficacy of treating two patient group (Group 1, patients receiving nitrates in combination with parmidin and Group 2, those taking nitrates) revealed that the two groups did not differ greatly in the clinical effects. In heart failure patients with high capillary permeability, parmidin substantially decreased the permeability to protein, which was associated with decreases in the baseline high activity of primary lipid peroxidation product in plasma red blood cells, which was not observed in the controls. At the same time parmidin was demonstrated to exert an unfavourable effect on microhemocirculation and to increase the patient's autosensibilisation.