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In Vivo Human Head Regional Conductivity Estimation Using A Three-sphere Model

A precise estimate of the electrical conductivity of each constituent tissue of the head is necessary for proper biophysical modeling of the EEG and MEG. A method is proposed and tested to calculate scalp, skull, and brain conductivities based on measurement of the induced potential field produced by injection of a known current across the head in vivo. Initial estimates in four subjects give the ratio of scalp to skull conductivities in the range 100-300. This is higher than expected, but may be caused by imprecise localization of the measuring electrodes.