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Comparison of Handling-Injection Stress with Noise Stress on Learning and Memory in the Early Life of Male Rats

Effects of stress on learning and memory in the early life have been one of the hot topics in neuroscience. The aim of this study was to investigate the combined effects of handling-injection stress with noise stress in the passive avoidance task in rats. The performance of rats was evaluated in the retention test 24 h after a single acquisition trial. Male Wistar rats were divided into 4 groups of 6 animals for 4 weeks: subcutaneous injection ofss sodium chloride 0.9% and handling stress (I+H), subcutaneous injection of sodium chloride 0.9% and handling with noise exposure (I+N), noise exposure (N) and control (C). After 4 weeks, we studied passive avoidance conditioning test in a shuttle box. The step-through latency after training animals significantly increased in (I + H) group as compared with (I+N) and (N) groups (p<0.01). But using noise stress with handling-injection stress significantly attenuated learning and memory in the (I+N) group than other 3 groups (p<0.05). The data suggested that moderate stress (handling-injection) increased learning and memory in the early life of animals but using moderate stress with sound stress impaired them.