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A Study of Lipid Profile and Glycosylated Haemoglobin in Hypertensive

Essential hypertension is a complex multifaceted disorder, which may include other abnormalities including dyslipidemia, central obesity, glucose intolerance and hyperinsulinemia. All these may increase the risk of coronary heart disease, stroke and other vascular complications. Worldwide raised blood pressure is estimated to cause 7.5 million deaths, about 12.5 per cent of all annual deaths. A case-control study was carried out on patients attending the General Medicine OPD of J N Medical College, Aligarh. The study was done to assess the levels of lipid profile and glycosylated haemoglobin in hypertensive subjects. We included forty non-diabetic and hypertensive subjects as cases and forty non-diabetic and non-hypertensives as controls. Cardio-vascular parameters, lipid profile, blood sugar and glycosylated haemoglobin were measured for all the subjects. We found a significant decrease in HDL (p<0.01), Significant increase in TC/HDL Ratio ( p<0.01) And increase Glycosylated Hb (p< 0.01) in non-diabetic hypertensive subjects as compared to non-diabetic, normotensive controls. No significant difference was found in total cholesterol, LDL, VLDL, triglycerides and blood sugar level of cases and controls in our study. The low HDL levels and abnormal TC/HDL ratio should be taken into account while assessing the future risk of coronary heart disease as well as drug therapy of hypertension. The estimation of glycosylated haemoglobin can be beneficial to assess the severity and complications of hypertension and its’ prevention.