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Low Incidence of IDDM in Children of Veracruz-Boca del Rio, Veracruz: Results of the first validated IDDM registry in Mexico

4.9 and 4% in NIDDM patients and control subjects, respectively, and 14.4 and 18.4% for the His63Asp mutation. Only one NIDDM patient was found homozygous for the Cys282Tyr mutation. When the NIDDM patients were analyzed according to the presence of either HFE mutation, no difference between the patient groups was observed with regard to the frequency of family history of NIDDM, age at diagnosis, presence of obesity, presence of liver enzyme abnormalities or hyperlipidemia, or requirement for insulin therapy. The same results were observed when the patients were analyzed according to phenotypic combinations of the two mutations. Serum iron and transferrin saturation and ferritin concentration were significantly increased (by an average of 22, 30, and 15%, respectively) in patients expressing HFE mutations compared with those without any mutation.