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Seroepidemiological profile of 50 AIDS patients in Kerala.

The epidemiological and Western blot profile of 50 patients with AIDS presenting to the AIDS Surveillance Centre at our college between March 1993 and October 1994 was carried out. There were 47 males and 3 females. 22 of the 47 males and all 3 females died. Most of the patients (41%) were 21-40 years of age and the main mode of transmission was the heterosexual route. In 5 of the patients the route of transmission could not be determined. The main source of infection was female sex workers in Mumbai Maharashtra. The clinical diagnosis at the time of presentation was tuberculosis in 25 patients; 18 of them had pulmonary tuberculosis. Using the recombinant Western blot (HIV blot 2.2) technique 5 patients had combined HIV 1 and II infection while the rest had only HIV I infection. Among the various HIV products identified in the serum envelope antibodies were present in 46 patients and p31 antibodies in 32. Based on this data we feel that preventive strategies must be targeted at high-risk groups all over the country and not only in areas with a high incidence of the disease. Tuberculosis centers should have facilities to diagnose HIV infection as half these patients present with tuberculosis. (full text)