{'fraction_non_alphanumeric': 0.0332409972299169, 'fraction_numerical': 0.012465373961218837, 'mean_word_length': 5.025, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Regulatory IgA response

Neuroimmunology
Multiple sclerosis (MS) is associated with the production of oligoclonal immunoglobulin G (IgG) antibodies within the central nervous system (CNS), but less is known about the status of IgA-producing cells. Probstel et al. detected clonally expanded IgA+ cells in cerebrospinal fluid and tissue adjacent to areas of active MS-associated demyelination. Recombinant IgA antibodies assembled from the cloned antibody genes bound to surface antigens found on multiple bacterial phyla but did not cross-react with brain tissue. Recruitment of gut-associated IgA+ B cells and plasma cells to the CNS is a potential biomarker of disease activity in MS.

Sci. Immunol. 5 , eabc7191 (2020).