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A pair of naturally occurring antibodies may dampen complement‐dependent phagocytosis of red cells with a positive antiglobulin test in healthy blood donors

Background and Objective  It is known that red blood cells (RBC) from healthy blood donors with a positive direct antiglobulin test (DAT) for IgG continue to circulate despite carrying elevated numbers of IgG molecules. To unravel the properties of these RBC‐bound IgG, we studied them not only on whole RBC populations, but also on density‐fractionated RBCs.