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Lymphocyte subset reconstitution patterns in children with small bowel transplantation induced with steroid‐free rabbit anti‐human thymocyte globulin

Abstract: Multiple measurements (n = 212) of lymphocyte subsets in 67 children treated with steroid‐free Tacrolimus, and rabbit anti‐human thymocyte globulin induction demonstrate early reconstitution of T‐cytotoxic and NK cells. Reconstitution of CD4+ cells is complete after the second post‐transplant year. During the period at risk for rejection, NK and T‐cytotoxic cell counts are significantly higher among Rejectors. During periods at increased risk for EBV viral infection, CD4 counts bear a significant inverse relationship to EBV viral load in a subset of at‐risk recipients. Rejection‐prone children also demonstrate significantly higher counts of total lymphocytes, Tc and NK cells prior to SBTx, and may illustrate one basis for enhanced baseline immunocompetence.