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The effect of age on the hydroxylation of amylobarbitone sodium in man.

1 Following a single oral dose of amylobarbitone sodium it has been shown that a group of young subjects convert a higher proportion of the dose to 3'-hydroxyamylobarbitone than a group of elderly subjects. 2 Twenty-four hours after the administration of the drug, the mean plasma level of amylobarbitone in the elderly group is significantly higher than in the group of young subjects. 3 It is concluded that the rate of hydroxylation of amylobarbitone sodium decreases with age.