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Late Radiation Outcomes of Patients with Newly Diagnosed Glioblastoma Treated with Accelerated Hyperfractionated Radiotherapy and Temozolomide

METHODS Between 2006 and 2007, 32 consecutive patients with glioblastoma were treated with AHRT and TMZ. The total dose of 66 Gy was administered in 33 fractions within 6 weeks. In phase I, PTV1 received 40 Gy (2 Gy per fraction, five times per week). In phase II, 26 Gy was delivered to PTV2 by adding a second daily fraction at intervals of 8 hours once every 3 days. All patients received chemotherapy according to the Stupp protocol. Toxicities were evaluated based on the CTCAE v3.0.