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METOCLOPRAMIDE‐INDUCED VASCULAR HYPERREACTIVITY: A COMPARATIVE STUDY BETWEEN NORMOTENSIVE AND HYPERTENSIVE SUBJECTS

In the present study, we have evaluated the cardiovascular responses to the cold pressor test (CPT) under intravenous metoclopramide (MTC) treatment (7.5 μg kg-1 min-1) during a 30-min period and two additional periods, before and after MTC by using 5% glucose solution. There was a vascular hyperreactivity induced by MTC, mm Hg was 21.4/24.1 mm Hg (systolic/diastolic blood pressure [BP]) during MTC versus ± 17.2/17.9 mm Hg during 5% glucose infusion. In nine hypertensive subjects, ± mm Hg was 36.8/25.7 during MTC versus ± 31/24 mm Hg during 5% glucose. Bromocriptine pretreatment (7.5 mg daily for 7 days) antagonized MTC-BP increase during CPT. We conclude the following: (1) MTC induces a greater BP response during CPT which is blocked by using bromocriptine, a known DA2 dopaminergic agonist. (2) A dopaminergic influence is present during CPT in normotensive and hypertensive subjects.