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Serum lipoprotein and apolipoprotein concentrations and tissue lipoprotein‐lipase activity in overt and subclinical hypothyroidism: the effect of substitution therapy

Abstract. Twenty‐one patients with increased, thyroid‐stimulating‐hormone (TSH) concentrations in the serum while fasting were studied before and after substitution with l‐thyroxine. Nine patients had TSH values < 40 mU/1 and an average serum‐thyroxine value of 64 nmol/1. Twelve patients with TSH‐values > 40 mU/1 had an average serum‐thyroxine value of 23 nmol/1. On treatment TSH and thyroxine normalized (reference limits < 8 mU/1 and 65–160 nmol/1 respectively) as did also the response to a load with thyroid‐releasing hormone (TRH).