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In vitro Tests of Thyroid Function in Active Thyroglobulin Immunity 1 2

Summary The sensitivity of in vitro thyroid function tests (charcoal 125I–T3 uptake ratio, total serum T4) in reflecting antibody transport of thyroxine was evaluated in the sera of rabbits with varying amounts of thy-roxine-binding antibodies as facilitated by bleeding rabbits at various intervals after bovine thyroglobulin immunization. Concurrent paper electrophoretic studies of distribution of 125I-T4 in thyroglobulin immune sera were also carried out. In sera with a very low titer of T4-binding antibodies as revealed by a slight retention of 125I-T4 by gamma globulin in paper electrophoresis, in vitro tests did not provide consistent sensitivity in reflecting such abnormalities in thyroxine transport. In general when paper electrophoretograms of immune sera containing 125I-T4 showed gamma globulin retention of more than 10% of total radioactivity, in vitro thyroid function tests in such immune sera did reflect changes in a direction consistent with that expected in the context of increasing number of T4-binding sites (as provided by thyroxine-binding antibody molecules). In contrast to the changes in 125I-T3 ratio and total T4 noted in thyroglobulin-immunized animals, marked changes in these thyroid parameters were not noted in albumin-immunized or adjuvant-treated controls.