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Diagnostic and Prognostic ability of salivary MMP-9 and S100A8 for periodontitis.

OBJECTIVES
Salivary diagnostic using matrix metalloproteinase (MMP) and S100 for periodontitis is a promising issue. However, its prognostic effect is still unclear. This study aimed to evaluate the prognostic ability of salivary MMP-9 and S100A8 for periodontitis through non-surgical periodontitis treatment clinical trial.


MATERIALS AND METHODS
Total 149 participants, 99 periodontitis and 50 healthy, were recruited. Among 99 non-surgical periodontitis treatment participants, 74 participants were revisited after three months. Periodontitis was classified as stage II-IV of new classification of periodontitis proposed at 2018. Enzyme linked immunosorbent assay kit was used to quantify salivary MMP-9 and S100A8. Receiver operating characteristic curve was applied for diagnostic ability. Paired T-test was applied for prognostic ability evaluating changes in salivary markers between pre- and post-treatment.


RESULTS
Salivary MMP-9 and S100A8 were associated with periodontitis (p <0.05). The screening ability of algorithm using salivary MMP-9 and S100A8 for periodontitis was 0.86 (p <0.05). After treatment, reduction rate of salivary S100A8 and MMP-9 were 83.7% and 23.5% respectively (p <0.05): only salivary S100A8 was superior compared to clinical parameters.


CONCLUSION
Algorithm using salivary MMP-9 and S100A8 showed high diagnostic power for periodontitis. Both Salivary S100A8 and MMP-9 showed prognostic ability for periodontitis, but S100A8 was better.