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A biosensor chip design for phase-stepping interferometry of surface plasmon resonance

We proposed a simple and low cost approach for fabricating SPR biosensor chips. For SPR imaging sensor applications, the requirement of the sensing chip design is different from typical flow-cell configurations in terms size, number of channels and optical coupling surface quality. In order to fulfill the requirements of practical applications, we present several designs for both single and multi-channel bio-chips. Moreover these modules are easy to fabricate with no special requirements on tools. This leads to low-cost and multi-channel bio-chips integrated with a flow-cell for a range of customized SPR sensing applications.