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Enhancement of protection against influenza by complex prophylactic schemes.

A hundred percent protection against influenza was obtained by means of joined application of two antiinfluenza vaccines [inactivated and live ones]. At the same time complete mobilization of various specific mechanisms of protection against influenza [humoral, cellular and local] was observed. This mode of vaccination was designated for protection against influenza of persons exposed, in the course of influenza epidemics, to enhanced possibility of getting infected [medical personnel, teachers, employees of public transport, shop assistants and others]. The second complex scheme of protection - simultaneous vaccination against influenza and tuberculosis - showed and made possible nonspecific stimulation of a specific protection against influenza by BCG vaccine. As a result frequency of seroconversion with regard to influenza amounted to 96%, the increase of influenza antibodies was 21.2 fold, their mean geometrical titers [inverse value] being 182.0. Also other problems connected with elaboration of complex schemes of protection against influenza by means of inactivated vaccines were investigated. The author presents concrete proposals for enlarged mutual elaboration by specialists of member countries of CMEA [Council for mutual economic assistance] not only of new complex schemes for influenza control but also for cooperation on other problems.