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[ICAM-1 mRNA expression in the bronchial tissue of asthmatic guinea pigs].

To determine the expression of ICAM-1 mRNA in the bronchial tissue of asthmatic guinea pigs. The guinea pigs were divided randomly in to asthma, asthma treated with dexamethasone (DEX), and control groups. ICAM-1 expression was analyzed by in situ hybridization and the cellular infiltrate was evaluated by HE staining. In situ hybridization demonstrated ICAM-1 mRNA was mainly expressed in the cytoplasm of epithelial cells and endothelial cells. Compared with the control and DEX groups, a significant increase of ICAM-1 mRNA expression was observed in the bronchial tissue (P < 0.02 and 0.05 respectively). In asthmatic guinea-pigs, the intensity of ICAM-1 mRNA expression in bronchial tissue was correlated with total leucocyte infiltrate (P < 0.05). ICAM-1 expression in bronchial tissue may be related with the leucocyte infiltration and glucocorticoid may inhibit the expression of cell adhesion molecules.