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T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains

Autism spectrum disorder (ASD) affects 1 in 59 children, yet except for rare genetic causes, the etiology in most ASD remains unknown. In the ASD brain, inflammatory cytokine and transcript profiling shows increased expression of genes encoding mediators of the innate immune response. We evaluated postmortem brain tissue for adaptive immune cells and immune cell–mediated cytotoxic damage that could drive this innate immune response in the ASD brain.