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Glucocorticoids modulate Kvβ1 dependent cardiac function through potassium channel (Kv) activity

Cortisone is a glucocorticoid used for treatments including arthritis, immune system disorders, allergic reactions, and eye conditions. Glucocorticoids however, have the propensity to produce multiple cardiovascular effects including hypertension, hyperglycemia and dyslipidemia. Therefore in patients with history of cardiovascular diseases corticosteroids are used with caution due to high risk of myocardial injury. In vitro research has demonstrated cortisone and its analogs alter voltage‐gated potassium channels (Kv) via the Kvβ1.1 subunit. Recently we published that both male and female Kvβ1.1 knockdown (KO) mice demonstrate significant prolongation in left ventricular action potentials in addition only females presented with significantly elevated blood pressure levels including systolic and diastolic.