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Disposal of cell debris from surplus lactotrophs of pituitary gland.

In rats submitted to physiological and experimental stimulation of lactotrophic secretion, as in pregnancy and lactation as well as after estrogen treatment, there is a remarkable proliferation of lactotrophs in the pituitary gland. After interruption of the stimuli, this situation is reversed to basal conditions via a massive programmed cell death of the surplus lactotrophs. The regressive changes occurring in lactotrophs are autolytic in nature, until the advanced stages of degeneration when the cell debris generated by this process are engulfed by phagocytes exhibiting the morphological characteristics of stellate cells. These cells can be seen within the anterior pituitary parenchyma adherent to the wall of capillaries and in the lumen of blood vessels. The number of stellate cells with engulfed lactotroph cell remnants is relatively small in comparison to the massive cell death, an observation that suggests a rapid clearance of cell debris and phagocytic cells from the pituitary parenchyma into the blood stream. The migration of stellate cells from the adenohypophysis involves the degradation of the basement membrane and rearrangement of the capillary wall components. The final disposal of cell debris of regressing lactotrophs within the anterior pituitary therefore appears to be effected by coordination of a pituitary and systemic mononuclear phagocytic system.