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Congenital afibrinogenemia: report of three cases

One female and two male infants, aged 2, 3 and 5 months, respectively, presented with uncontrolled bleeding from the umbilical stump and hematoma formation at intramuscular (vitamin K) injection sites. They were all products of firstcousin marriages and had been born at full term by normal, vaginal delivery. The number of siblings varied from one to three. There was no family history of bleeding tendency in any of the families. On examination, no abnormality was detected except for oozing from the umbilical stump and hematomas at injection sites. Blood counts and liver function tests were normal in all infants. However, prothrombin time (PT), partial thromboplastin time with kaolin (PTTK) and thrombin time (TT) were infinitely prolonged in all three patients but were normal in their parents. Fibrin degradation products were not detected in