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[Effect of triterpene glycosides on the stability of bilayer lipid membranes, containing different sterols].

Low concentrations of triterpene glycosides: holothurin A, stichoposide A and cauloside C sharply change the stability of bilayer lipid-sterine membranes. The glycosides activity decreases in the line: holothurin A, stichoposide A, cauloside C. The effective doses of glycosides are to a great extent determined by structural peculiarities of sterines which compose the films. A correlation was observed between the effect of triterpene glycosides on the stability of model bilayer membranes and their physiological activity. The model lipid-sterine membranes can be used in the primary screening of triterpene glycosides to estimate their physiological activity.