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Impact of ABCB1 gene polymorphism on opioid dependence and analgesic tolerance

Drug dependence has been a hot topic in neuroscience research due to its complicated pathogenesis. Recently,huge scientific efforts have been continuously put into understanding the association between drug dependence and polymorphism in ATP-binding cassette subfamily B member 1 transporter( ABCB1) gene,especially a mutation in exon 26 at position3435( 3435 C T). This article reviews the relationship between opioid dependence and analgesic tolerance and ABCB1 gene polymorphism,which will shed light on the underlying mechanisms of drug dependence and optimal MMT programs for individuals.