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The Induction of Autoreactive T Lymphocytes by Allogeneic Effect Factor (AEF): Relevance to Normal Pathways of Lymphocyte Differentiation

Soon after the discovery of the collaboration between thymus-derived (T) and bone marrow-derived (B) lymphocytes in the development of humoral immune responses (Claman et al. 1966, Davies et al. 1966, Mitchell & Miller 1968), it was found that a soluble mediator generated in a mixed lymphocyte culture {MLC) could have profund effects on in vitro antibody responses to T-dependent antigens (Dutton et al, 1971), In the subsequent 9-year period there have been numerous reports about the ability of antigen-nonspecific soluble mediators, derived mostly by alloantigen or mitogen stimulation of T cells, as well as antigen-specific factors, to replace the normal requirement for carrier-specific helper T cells in antibody responses (reviewed in Katz 1977),