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Angiotensin-(1-7) intracerebroventricular administration generates nociceptive effects in hot-plate task and decreased oxidative stress in the temporal lobe

Lately, there is increased evidence that besides the very well known angiotensin (Ang) II, other renin-angiotensin system (RAS) peptides, including Ang III, Ang IV or Ang-(1–7), could mediate important effects at the central level. Thus, very few aspects are known about the central actions of Ang-(1-7), while the effects of its administration alone on nociception were very rarely tested to date, according to the best of our knowledge. Thus, we were interested in studying the effects of Ang-(1-7) intracerebroventricular administration on nociceptive sensibility, as expressed by the main behavioral parameters in the hot-plate task, a fundamental behavioral tool for the study of pain in rodents, as well as the importance of Ang-(1-7) in the oxidative stress status from the temporal lobe, which is considered one of the most vulnerable brain regions to the oxidative status modifications. Thus, we report here for the first time upon our knowledge a possible nociceptive effect of Ang-(1-7) intracerebroventricular administration, as demonstrated by increased latency-time in the hot-plate task. Moreover, it seems that oxidative stress could be implicated in these aspects, since we found a significant correlation between the latency-time in the hot-plate and the levels of most of the oxidative stress markers from the temporal lobe (such as the glutathione peroxidase enzymatic specific activity or the levels of the main peroxidation marker malondialdehyde). Thus, our results could suggest new perspectives and studies regarding the possible usage of brain RAS in pain management. Still, additional studies are required in order to better understand the effects of Ang-(1-7) administration on nociception and oxidative stress status and also on the possible correlation that might exist between these two aspects.