{'fraction_non_alphanumeric': 0.023493975903614458, 'fraction_numerical': 0.0012048192771084338, 'mean_word_length': 5.539370078740157, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Seminal osteopontin relationship with semen variables in infertile men with varicocele

PurposeTo assess seminal plasma osteopontin (OPN) relationship with semen variables in fertile and infertile men with varicocele (Vx). Patients and methodsA total of 88 men were investigated, who were divided into the following groups: healthy fertile men without Vx, healthy fertile men with Vx, oligoasthenoteratozoospermic (OAT) infertile men without Vx, and OAT infertile men with Vx. They were subjected to assessment of history, clinical examination, semen analysis, and assessment of seminal OPN, malondialdehyde (MDA), and glutathione peroxidase (GPx). ResultsInfertile men associated with Vx showed a significant increase in seminal OPN and MDA, and a significant decrease in seminal GPx compared with infertile men without Vx and fertile men with or without Vx. Infertile men without Vx showed a significant increase in seminal OPN and MDA, and a significant decrease in seminal GPx compared with fertile men with or without Vx. Fertile men with Vx showed a significant increase in seminal OPN and MDA, and a significant decrease in seminal GPx compared with fertile men without Vx. Seminal OPN showed a significant positive correlation with seminal MDA, significant negative correlations with sperm count, sperm motility, sperm normal forms, seminal GPx, and a nonsignificant correlation with age. ConclusionSeminal OPN is significantly increased in infertile OAT men associated with Vx. Seminal OPN showed a positive correlation with seminal MDA and sperm abnormal forms and a significant negative correlation with sperm count, sperm motility, and seminal GPx.