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Hydrogen Bonding Patterns and Dynamics in Biological Macromolecules

Hydrogen bonds always involve hydrogen atoms which cannot be located by x-ray diffraction methods in macromolecular structures above 2000 daltons. Application of neutron diffraction could resolve this problem if technical problems like low flux and limited size of crystals were solved. Small biological molecules can serve as a first step in these investigations in order to derive basic principles. Suitable model systems for such studies are cyclodextrins which contain a large number of OH groups. They co-crystallize with water and provide new insight in the formation and dynamics of hydrogen bonding patterns. 18 refs., 10 figs., 2 tabs.