{'fraction_non_alphanumeric': 0.017279821627647716, 'fraction_numerical': 0.010590858416945374, 'mean_word_length': 5.0641891891891895, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Effect of lipid-lowering therapy on the mortality among patients with coronary heart diseases: A systematic review

Introduction: Studies supported the use of lipid lowering therapy such as statin as a treatment of 
hypercholesterolemia for prevention of CHD. However, the use of lipid lowering therapy is not well 
established in clinical practice due to lack of robust evidence and contra-indications in patients with 
heart failure (HF). This review aimed at evaluating the evidence about preventive effect of lipid 
lowering therapy on the mortality caused by coronary heart diseases. Methods: A comprehensive 
electronic search was carried out using MEDLINE, EMBASE, Cochrane databases to identify articles 
which aimed at assessing the preventive effect of lipid lowering therapy for coronary heart diseases. 
The data were collected from included studies using data collection sheets using specific items such as 
mean patient age, type of coronary disease, mean duration of the disease, drugs of lipid lowering 
therapy, regime of lipid lowering therapy, duration of lipid lowering therapy, reduction in mortality 
rate, and associated side effects. Results: Following evaluation of the eligible articles, 11 articles were 
included with randomized controlled trials investigating the effect of lipid-lowering therapy on the 
mortality of patient suffering from coronary heart diseases. The sample size in the included studies 
ranged from 106 to 10355 participants, and the total number of participants among all included studies 
were 50830 with mean age ranging from 31 to 82 years old. Conclusions: Despite the overall good 
outcome that is attributed to the use of statins that is not clear weather this benefit is credited to its anti- 
inflammatory or direct LDL lowering effect.