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The Role of Simvastatin on Postoperative Peritoneal Adhesion Formation in an Animal Model

Aim: The aim of this study is to show the effect of simvastatin on intra-abdominal adhesion formation. Method: Adhesion formation was achieved by scratching the cecum and anterior abdominal wall following median laparotomy. Three different groups of 10 rats each were formed. In group I, 0.57 mg/kg/day simvastatin was injected intraperitoneally right after the operation and for 5 days thereafter. In group II, an equal dose of simvastatin to that used in group I was given via gavage. A physiological saline solution was given to group III for the same period of time. On the 6th and 14th day, blood samples were taken and peritoneal lavage was performed to measure the tissue-type plasminogen activator (t-PA) activity. Adhesions were graded via re-laparotomies on the 14th day after the first operation. Results: The adhesion scores were 1.40 ± 0.22, 1.50 ± 0.26, and 2.90 ± 0.34 in groups I, II, and III, respectively (p = 0.007), and the score was higher in group III than in the other groups (p = 0.005, p = 0.011). Conclusion: Intraperitoneal simvastatin application decreases adhesion formation by increasing the t-PA level in abdominal surgery.