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(3) Evaluation of a unique new compression bandage in the treatment of venous ulcers

The spindle cells tended to be arranged in well-defined fascicles present at all levels in the dermis and often extending into the fat. Nuclear atypia and mitotic activity were, as a rule, not conspicuous. Both perineural and intraneural tumour spread was noted in some biopsies. Usually serial sections revealed atypical melanocytic hyperplasia in parts of the overlying epidermis and junctional nests were occasionally seen. It was unusual to find direct evidence of transformation of LM melanoma to a DMM pattern. The histology of biopsies in this series had been misinterpreted as lupus erythematosus and other benign inflammatory or scarring processes, neurofibroma and fibrosarcoma. Immunocytochemical labelling for Sioo protein and with the anti-melanoma antibodies HMB45 and NK1C3 was usually positive in most of the spindle cells. Immunocytochemistry should help prevent errors in the histological diagnosis of this rare type of melanoma.