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CUTANEOUS SHOCK PRODUCES CORRELATED SHIFTS IN SLOW POTENTIAL AMPLITUDE AND CYCLIC 3′,5′‐ADENOSINE MONOPHOSPHATE LEVEL IN THE PARIETAL CORTEX OF THE CONSCIOUS RAT 1

Abstract— Fourteen animals each received 4 cutaneous shocks with an interval of 3–5 min between them. During a fifth trial 3–5 min later, eleven subjects received a fifth shock and then 3–30 s afterwards, as cerebral slow potentials developed in response to the stimulus, samples of parietal cortex were rapidly frozen and extracted by a cryoplate. Three baseline subjects received no shock at the time of the fifth trial and had their parietal tissue samples taken without the presence of slow potentials. A correlation coefficient of r=−0.77 (P < 0.01) was observed between the slow potential amplitude on the surface of the parietal cortex at the time of the sampling and the analyzed level of cyclic AMP in the underlying tissue. Five of the shocked animals whose samples were taken before the slow potentials increased significantly showed a tissue level of 11.1 ± 3.0 pmol cyclic AMP/mg protein. This level was significantly higher (P < 0.01) than that of the baseline animals (3.1 ± 2.0 pmol cyclic AMP/mg protein). The other six shocked animals who had developed large slow potentials manifested a cyclic AMP level that was not different from the baseline group. It is concluded that a reoccurring cutaneous shock results in the immediate increase in the level of cyclic AMP in the parietal cortex and that within 30 s this level decreases in proportion to the amplitude of the slow potential that develops in the same region.