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Neurologic, pulmonary, and cutaneous toxicities of high-dose chemotherapy.

PURPOSE/OBJECTIVES
To discuss dose-intensive chemotherapy and the associated toxicities to the nervous, pulmonary, and cutaneous systems.


DATA SOURCES
Published articles, book chapters, and personal experience.


DATA SYNTHESIS
Because of the discovery of the protective effect of colony stimulating factors, a renewed emphasis has been placed on dose-intensive chemotherapy in an attempt to affect both survival and cure rates with chemotherapy. As a result, increased toxicities have been seen in other organ systems.


CONCLUSIONS
Toxicities to the nervous, pulmonary, and cutaneous systems are increasing. Meticulous medical and nursing care are critical to ensure patient survival and to minimize these effects.


IMPLICATIONS FOR NURSING PRACTICE
Goals of care include a through knowledge of potential toxicities, recognition of signs and symptoms of toxicity, and appropriate nursing interventions once such deficits occur to decrease the toxic effects of chemotherapy and improve patient function.