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A biotech takes a risk on a distant supplier

In 2004, Winston Wu was at a crossroads. A principal scientist and project leader at Schering-Plough, he had worked as a chemist at big companies for almost 12 years. He had learned a lot about chemical development but was finding his opportunities for growth to be limited. He considered joining a contract research or manufacturing firm, possibly one in his native China. Instead, he accepted a job at a small biotech called Lexicon Pharmaceuticals. The firm was about to advance a compound into development, and Wu reasoned that he could aid that effort with the skills he had developed at Schering-Plough. That is indeed how things worked out for Wu, who today is Lexicon’s vice president of chemical development. In early 2017, Lexicon won US Food and Drug Administration approval for Xermelo, a treatment for diarrhea that can accompany a rare cancer called a carcinoid tumor. Through his management of