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Twenty-five years of HIV management

In 1981 the first case of AIDS was reported.1 A quarter of a century on, the AIDS epidemic has claimed the lives of more than 25 million people. It has rapidly become one of the most highly publicized, and politicized, infectious epidemics. Over these 25 years, we have also made remarkable advances in diagnosis and therapy. What follows is an update on the state of play at the end of 2006.