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[Comparative study of urine immunoelectrophoresis and 4 indexes of glomerular selectivity in chronic glomerulopathies].

Glomerular selectivity has been evaluated in a group of 89 patients, using renal clearances of orosomucoid (Cl O), transferrin (cl T) and immunoglobulin G (Cl IgG). In all cases, protein excretion was found above 0,30 g/24 h and urinary immunoelectrophoresis (IEP) showed a glomerular pattern. Clearance ratios Cl IgG/Cl T and Cl T/Cl O as well as Joachim's and Sabot's indexes were correlated to IEP patterns, protein daily excretion, creatinin clearance and pathological findings. The ratio Cl T/Cl O and Joachim's and Sabot's indexes correlated significantly with IEP patterns while Cameron's ratio (Cl IgG/Cl T) did not. Criteria other than Cameron and Joachim's indexes were found to be related to protein excretion; all indexes, Cameron's excluded, were influenced by renal functional status. Progress may be expected from the simultaneous serum and urine determinations of 5 proteins in the range 40 000-1 000 000 molecular weight with more accurate techniques such as laser nephelometry.