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Barbiturate withdrawal syndrome in a passively addicted infant.

An infant suffered acute episodes of seizures and severe central nervous system hyperirritability during the immediate neonatal period and again at the age of four months. Both attacks developed after abrupt termination of long-term barbiturate exposure. The first followed continuous secobarbital exposure in utero, and the second occurred after separation from the mother, who for weeks had been administering high doses of secobarbital to the infant. The authors believe the patient represents the first recorded case of neonatal barbiturate withdrawal syndrome and that congenital barbiturate addiction is more common than realized.