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Perinuclear formation of Reactive Nitrogen Species causes DNA damage in Methicillin‐resistant Staphylococcus Aureus induced sepsis.

MRSA commonly referred to as a 'super bug' because of its resistance to antibiotic therapy, is now a common infection encountered in hospitals and communities. We have previously shown that MRSA causes vascular hyperpermeability, multi‐organ system failure, and death in our ovine model of MRSA‐induced sepsis. We hypothesized that RNS may play a pivotal role in MRSA‐induced DNA damage and consequent cellular death.