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Resveratrol inhibits ovarian cancer cell growth through epigenetic regulation of Wnt antogonist SFRP5

Ovarian cancer (OC) is the most lethal gynecologic malignancy. OC is the top ten of cancer in females in Taiwan and all over the world. Cancer metastasis follows with epithelial mesenchymal transition (EMT). The Wnt/β‐catenin signaling pathway is associated with EMT. The secreted frizzled‐related proteins (SFRPs) act as antagonists of the Wnt ligands and inhibit the Wnt/β‐catenin signaling pathway. In the past research indicated the resveratrol has the capacity for anti‐ inflammatory, anti‐ oxidant and anti‐cancer effects as well as involve in the DNA methylation regulation. It is helpful for inhibiting the tumor suppressor gene methylated and re‐expression. Therefore, the aim of this study is to investigate the effects of resveratrol on DNA methylation modification in ovarian cancer cell (SKOV3). Cell was treated with DMSO, 10 μM 5‐aza‐2′‐deoxycytidine (DAC), 5 μM DAC, 45 μM resveratrol, and resveratrol combined with 5 μM DAC in 96 hours, extracting the DNA and protein for further analyze, respectively. The data show that resveratrol may inhibit total DNMT activity, DNMT3a protein expression, regulate tumor suppressor gene SFRP5 expression by combined with 5 μM DAC and regulate Wnt/β‐catenin signaling pathway, as a result, it can attenuate or inhibit the ovarian cancer development.