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Thrombocytopenia and Altered Platelet Kinetics Associated with Prolonged Pulmonary-artery Catheterization in the Dog

The authors studied platelet kinetics in healthy dogs subjected to pulmonary-artery (Swan-Ganz) catheterization. Ten dogs with a mean weight of 11.0 ± 1.12 kg (SD) were equally divided into experimental and control groups. A fraction of platelets from each dog was harvested, labelled with 51Cr, and reinfused. Daily blood samples for determinations of radioactivity and platelet count were obtained. From the third to fifth day after platelet labelling, experimental dogs underwent catheterization with Swan-Ganz catheters. During 48 hours following catheterization, platelet counts decreased 64.2 ± 15.2 per cent from baseline. There was no corresponding change in the control dogs. Calculated platelet survival times (based on decay in platelet radioactivity over time) were 102 ± 6.5 hours for the experimental group and 139.8 ± 16.3 hours for controls (P < 0.01). Postmortem examination of one sample dog demonstrated thrombus formation along the length of the catheter and in the pulmonary artery. Significant thrombocytopenia with decreased platelet survival is associated with the use of Swan-Ganz catheters in dogs. The mechanism has not been defined. This observation adds an important consideration to the interpretation of platelet kinetics observed in many pathologic states in animal models.