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Photodynamic effects of Photodithazine on cervical cancer model

Photodynamic therapy (PDT) has been reported to be effective for treating various tumors and induce apoptosis in many tumor cells. In this study, we examined a biological significance of PDT with a new photosensitizer, Photodithazine, in a cervical cancer model using TC-1 cells. Also, to see the accumulation level of Photodithazine in tumours, we measured the concentration of Photodithazine at indicated time points in tumours of the mice injected with Photodithazine. When the tumor bearing mice were exposed to varied doses of Photodithazine with laser irradiation (300 J/cm2), retarded tumor growth was significant in mice treated with PDT, as compared to the control group. On the other hand, in the uptake of Photodithazine experiments showed that the highest accumulation of Photodithazine in tumors was shown at 0·5 hr after injection and its concentration was decreased. Photodithazine keeps high concentration values during the first day, Photodithazine showed a rapid clearance from sera as it is relatively long kept by tumor tissue. Taken together, we propose that PDT after the application of Photodithazine may be effective in the mice system.