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An Investigation of Dysfunction of Platelet and Intervening Treatment in Migraine Patients

Objective To discuss the relationship between the attack of migraine and the activation of platelets;and to observe the influence of Ticlid,the platelet inhibitive,on β-TG and PF4 of plasma.Methods We adopted the method of ELISA to determine the level of β-TG and PF_4 of plasma in the group of patients with migraine during attacks and the normal group.Results (1) In the group of migraine,the level of β-TG and PF_4 of plasma were both higher than the comparison group( P 0.001);at the same time,the two factors are positive-related ( r 0.49).(2) After treated with Ticlid,the concentration of β-TG decreased obviously compared with that before treatment( P 0.05).However,no significant change in statistics was found in the lower of the concentration of PF_4( P 0.05).(3) Meanwhile,the level of both β-TG and PF_4 of plasma had no significant change after treatment in the group without Ticlid( P 0.05).(4)The ratio of β-TG/PF_4,i n the comparison group and the migraine group before and after treatment,were all in normal range.The rate of improving is 28%.The effective rate is 40% and the total effective rate is 68%.Conclusion The attack of migraine has something connected with the activation and the release of the platelet,so it is important to give therapy and prevention.