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Ultrastructural analysis of pigmentary mosaicism: reduced melanosome granules within melanocytes

Pigmentary mosaicism has been proposed as a term to describe the pathogenesis of pigmentary anomalies along the lines of Blaschko. It is well accepted that pigmentary mosaicism includes hypomelanosis of Ito, linear hypomelanosis, linear and whorled nevoid hypermelanosis, nevus depigmentosus, and cutis tricolour, which are caused by a multitude of genetic defects [1]. Here, we describe a one-and-a-half-year-old Japanese female with bilateral hypopigmented streaks following the lines of Blaschko with [...]