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Epidemiology of Influenza Virus Reinfection: A Retrospective Analysis of a Nine-year Influenza Surveillance Data


 BackgroundEpidemiological characteristics profile of the reinfection of the influenza virus has not been well described. MethodsOur study estimated the reinfection rate using nine-year influenza surveillance data and further examined the characteristics associated with the reinfection. ResultsA total of 53,605.6 person-months and the median time of 8.7 months were observed for reinfection. The cumulative reinfection incidence was 2% at 6 months, 4% at 12 months, 5% at 24 months, and 7% after 59 months. Living in the rural area (HR=1.37 [95% CI 1.29-1.45]), and age ≤6 years (HR=11.43 [95% CI 9.47-13.80]) were independent risk factors associated with influenza reinfection. ConclusionsOur findings indicate that the reinfection of the influenza virus in Guangxi independently and positively associated with the rural area and younger age. The unusually high frequency of reinfection points to a need for further prospective longitudinal studies to better investigate sufficient impact on the development of broadly protective or universal vaccines.