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A Comparison of Acute Reversible Pre‐ and Postsinusoidal Portal Hypertension on Salt and Water Retention in the Dog

To define the relationship between portal hypertension and renal excretion of salt and water, two acute animal models of portal hypertension were investigated. In both models, it was necessary for systemic and renal hemodynamics to remain unchanged during the creation of portal hypertension so as to eliminate the effects of change in these parameters on renal excretion.