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Are there changes in leg vascular resistance during laparoscopic cholecystectomy with CO2 pneumoperitoneum?

Background:  The prompt haemodynamic response to carbon dioxide insufflation during laparoscopic cholecystectomy suggests involvement of the sympathetic system. The aim of the present study was to examine if a change in vascular resistance in leg skeletal muscle could be an important mechanism behind the increased afterload. Furthermore, the arterio‐venous differences of the catecholamines were measured in the leg before and during insufflation of carbon dioxide into the peritoneal cavity.