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FRI0130 Clinical and Imaging Differences between Patients with Familial Early Axial Spondiloarthritis and Sporadic Forms: Results from Esperanza Cohort

Background At present, there are few studies on how genetic factors may influence phenotypic expression in familial and sporadic early axial spondyloarthritis (axSpA). To help physicians better understand SpA, our group decided to analyse potential difference Objectives To evaluate the existence of clinical and imaging differences between patients with familial versus sporadic early axial spondyloarthritis Methods Baseline data from ESPERANZA program (<45 years old, symptoms duration 3-24 months and with inflammatory back pain -IBP- or asymmetrical arthritis or spinal/joint pain plus ≥1 SpA features) was used for a descriptive analysis. Patients fulfilling the ASAS classification criteria for axial SpA were included. Socio-demographic and disease characteristics, disease activity indices (ESR, CRP, BASDAI, BASFI), metrology (BASMI), quality of life (ASQoL) and imaging (total BASRI, radiographic sacroiliitis –NY criteria- and sacroiliitis on MRI -ASAS criteria-) were compared between patients with familial and sporadic axial SpA. Familial axial SpA was defined according to the ASAS/ESSG criteria definition as presence in first or second-degree relatives of any of the following: ankylosing spondylitis, psoriasis, uveitis, reactive arthritis, inflammatory bowel disease. Analysis: Chi square was used to compare rates and Student-t test to analyze continuous variables Results A total of 291 patients were included: 190 (65%) with sporadic and 101 (35%) with familial axial SpA. Sixty six % were male, with mean (SD) age 32 (7) years and disease duration of 13 (6.7) months. Statistically significant differences were found between both groups for the following parameters: age at symptom onset (29.4±9.2 vs 31.5±10 years; p<0.05) presence of HLA B27 (83% vs 71%;p=0.02), BASMI (1.2±13 vs 1.6 1.2; p=0.03) and presence of sacroiliitis on MRI (36% vs 47%;p=0.01). There were no significant differences in the others parameters studied between the two groups Conclusions Familial early axial SpA is related to manifestation of disease symptoms at a younger age, more frequency of positive HLA-B27 and higher spinal mobility while sporadic axial SpA is associated with the presence of sacroiliitis on MRI Acknowledgements Esperanza Program has been supported by an unrestricted grant from Pfizer Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.2054