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Aging‐induced Mitochondrial Dysfunction in the Mouse Brain Microvessels: Effect of Neuronal Nitric Oxide Synthase Inhibition

Aging‐induced cerebrovascular changes contribute to the increased risk of stroke and neurodegenerative diseases. Notably, aging‐induced impairments of cerebral microcirculation have been implicated in cognitive dysfunction. Mitochondrial dysfunction plays an important role in the age‐related cerebrovascular changes; however, mitochondrial respiratory dysfunction has never been studied in the microvasculature. Similarly, neuronal nitric oxide synthase (nNOS) is known to play a critical role in various cells of cerebrovasculature, but its effects on mitochondrial respiration in the young and aged brain microvessels have never been examined previously. Here, we studied the mitochondrial respiration and the responses to nNOS inhibition in the in the aged‐microvessels from mouse brain.