{'fraction_non_alphanumeric': 0.052552552552552555, 'fraction_numerical': 0.04804804804804805, 'mean_word_length': 4.711428571428572, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Impact of tumor aneuploidy in pseudomyxoma peritonei.

414 Background: DNA aneuploidy is an indicator of poor prognosis in epithelial cancers arising from the colon, rectum, kidney and breast. To our knowledge, there is no data on the occurrence of DNA aneuploidy in Pseudomyxoma peritonei (PMP). The aim of this study is to investigate the frequency of DNA aneuploidy and analyze its relation to clinicopathological characteristics of the patients.


METHODS
One hundred and twenty patients with PMP were analyzed. Flow cytometry was used on paraffin embedded tissue samples and multiple tissue blocks and serial sections were analyzed for each tumor. The results of DNA analysis were correlated to clinicopathologic data. Chi- square test was used to analyze categorical variables and t-test was used for continuous variables. Kaplan-Meier analysis was used to study impact of aneuploidy on survival.


RESULTS
Of 120 patients analyzed, 41.7% (70/120) patients had disseminated peritoneal adenomucinosis (DPAM), 32.5% (39/120) patients had either peritoneal mucinous carcinomatosis- intermediate type (PMCAI) or peritoneal mucinous carcinomatosis (PMCA) and 25.8% (31/120) had signet cell carcinoma (SCC). DNA aneuploidy was detected in 13% (16/120) of the PMP patients. The incidence of aneuploidy was 2% (1/50) in patients with DPAM, 25.6% (10/39) in patients with PMCAI or PMCA and 16% (5/31) in patients with SCC (p=0.004). Nearly 56% (67/120) of patients were males and 44% (53/120) were females. Gender did not impact the incidence of aneuploidy. Mean age of patients with aneuploid tumors and diploid- near diploid tumors was 56.8 (±13.5) years and 49.6 (± 11.8) years respectively (p=0.027). Median survival in patients with aneuploidy was 54 months compared to 100 months in patients with diploid/ near-diploid status (p=0.021).


CONCLUSIONS
Older age and high-grade PMP are associated with higher rates of aneuploidy. Aneuploidy was associated with worse survival in patients with PMP.