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TNF Nco‐I RFLP IS NOT AN INDEPENDENT RISK FACTOR IN RHEUMATOID ARTHRITIS

The human TNF genes are located within the MHC class‐III region on chromosome 6. The presence or absence of an Nco‐I restriction site in the 5’ non‐coding sequence of the TNFβ gene defines two alleles (TNFB*1 and TNFB*2). The segregation of these alleles has been associated with levels of TNFα or TNFβ production in systemic lupus erythematosis (SLE), insulin‐dependent diabetes mellitus (IDDM) and in healthy control individuals.