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EFFICACY AND SAFTEY OF SIX‐WEEKS OF PRE‐WORKOUT SUPPLEMENTATION IN RESISTANCE TRAINED RATS

Pre‐workout supplements contain a variety of compounds to improve performance, muscle strength and growth. However, efficacy and safety of many of these supplements is unknown. The purpose of this study is to determine whether 6 weeks of pre‐workout supplementation in rats undergoing a resistance training program significantly improves performance without any adverse effects on kidney or vascular function. 3 month‐old, male, F344 rats were divided into two groups (n=12/group): 1) control (CTRL) and supplemented (SUP). The SUP group was given Pro Supps Mr. Hyde™—a pre‐workout that contains 2–3 times the amount of caffeine than other brands. Resistance training consisted of climbing a 1 m wire ladder, at an 85° angle, 3d/wk for 6 weeks with increasing weight added to the tail. Aortic dose response curves to phenylephrine (PE, 10−7‐10−4 M), sodium nitroprusside (SNP, 10−8‐10−5 M), and acetylcholine (ACh, 10−7‐×10−5 M) were constructed. Two‐way ANOVA indicated a significant main effect of supplementation on the amount of weight lifted. No differences in body weight or muscle weight were observed. No changes in vascular function or urinary creatinine levels were observed. These data suggest that 6 weeks of pre‐workout supplementation in rats undergoing resistance training was moderately effective by increasing the amount lifted without a significant change in muscle size. Furthermore, no safety concerns related to kidney or vascular function were indicated following 6 weeks of use.