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Unilateral Asterixis Induced by Antiepileptic Drugs in Epileptic Patients with Structural Brain Lesion

It is well recognized that antiepileptic drugs (AEDs) can cause generalized or bilateral asterixis. However, the unilateral asterixis induced by AEDs has been rarely reported in patients with structural brain lesions. We report 2 patients who developed unilateral asterixis within therapeutic AEDs levels. In both patients, the unilateral asterixis disappeared when the daily dosage of AEDs was decreased. Our cases suggest that the cerebral hemisphere with structural lesions might be more vulnerable to the development of AEDs-induced asterixis.