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Receptors for α2‐Macroglobulin Are Present on Human Dermal Fibroblasts, but Not on Human Keratinocytes

The biological role of a2-macroglobulin (a2M) in tissues is not yet understood. In skin, several previous studies have shown that aZM is present in the dermal connective tissue, but not in the epidermis.' Furthermore, a2M receptors have been identified by immunohistochemical staining on dermal fibroblasts and dermal dendritic cells, but not on cells in the epidermal compartment.2 This suggests that a2M may play a role in homeostasis of the dermal connective tissue and that it is unlikely that azM interacts with keratinocytes in the epidermal compartment. In order to confirm this hypothesis, the presence of a2M receptors on human keratinocytes was studied using human dermal fibroblasts as a positive control for the presence of a2M receptors.