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Modulators of ion-transporting ATPases

This review focuses on ion-transporting ATPases which play an essential role in the generation and maintenance of ionic gradients between cell compartments and environment. There are three types of cation transporting ATPases: oligomycin sensitive F-ATPases, bafilomycin-sensitive V (vacuolar) H+-transporting ATPases (V-ATPases) and vanadate-sensitive P (phosphate binding) ATPases (P-ATPases), the most important of these being Ca2+-ATPase, Na+/K+-ATPase and H+/K+-ATPase. The influences of numerous modulators are reviewed.