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Ultrastructural Characterization of Nucleolar Organization in Human Gingival Fibroblast Overexpressing CEMP1

Periodontal disease affects a large part the population worldwide . Currently, numerous treatments have been tested for this condition, nevertheless none is able to achieve the periodontium regeneration . The main limitation is the cementum neoformation to restore the insertion of the periodontal ligament. Another problem is the fact that it is difficult to obtain and work with cementoblasts making more difficult the study of cementogenesis .