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The association of age and sexual history with the severity of the histological findings in women with cervical intraepithelial neoplasia.

We examined the demographic and behavioral data of 203 patients with histological diagnosis of cervical intraepithelial neoplasia (CIN) to assess putative predictors of the most severe alterations (CIN grade III). The variables significantly associated with the histological diagnosis of CIN III were time since first intercourse (odds ratio 5.33, 95% CI 1.80-16.15), time since menarche (odds ratio 4.62, 95% CI 1.39-16.05) and age (odds ratio 2.48, 95% CI 1.32-4.67). After multivariate analysis, the only independent variable still associated with CIN III was the time since first intercourse (odds ratio 6.11, p < 0.05). It is concluded that, in patients with recently diagnosed CIN, the time since first intercourse-rather than age, age at first intercourse or lifetime number of sex partners-is the information best associated with the severity of the disease.