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Group Inference For On-Going Activity : How to Compare Intrinsic Functional Connectivity Between Subjects

Ongoing processes account for a large fraction of the brain activity observed in functional imaging. The study of this intrinsic, or spontaneous, activity is currently a major field of research in neuroscience, as it opens the door to fundamental insights on brain architecture and can be applied to severely impaired patients for the study of pathologies. However, unlike with evoked activity, there is no universally-accepted standard analysis framework for group inference. This symposium will present latest progress in statistically-principled methods for intersubject comparisons of ongoing activity. It will feature different approaches used to test for differences in spontaneous brain activity between subjects or populations with neuroscientifically-relevant results, such as ICA or graphical models, and will focus on the statistics and interpretation issues raised by the inter-subjects comparisons.