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Improvement of fidelity of molecular DNA computing using laser spectroscopy

This work is devoted to application of laser Raman spectroscopy to improve the fidelity of molecular computing by DNA strands. The developed method provides determination of concentrations of specific nitrogenous bases not lower than 0.03 g l−1 and the accuracy of determining the total concentration of DNA in solutions 0.02–0.04 g l−1 by the Raman spectra of DNA solutions. The method allows us to control the temperature of DNA solutions in the process of molecular computing with an accuracy better than 0.2 °C. The obtained results provide required control of the parameters of DNA solutions to increase the speed and accuracy of solving the problems in the results of molecular computing.