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‘Identifying Brain Networks Controlling Micturition and Continence in Mouse’

Lower urinary tract symptoms (LUTS) are extremely common and enormously debilitating. A significant component of LUTS is due to failure of nervous control of bladder function, or otherwise failure of neural pathways to compensate for bladder dysfunction. It remains however unclear how the brain controls bladder filling and voiding and how the micturition reflex is inhibited at times when voiding is undesirable. Prior studies have shown that the pontine micturition center (PMC, aka Barrington's nucleus) directly controls voiding. PMC neurons provide direct innervation of sacral spinal cord nuclei that control bladder contraction and sphincter relaxation. Here we identify the neurochemical identity of PMC neurons that contribute to micturition control as well as identify a network of afferent neurons, spanning several forebrain and brainstem regions, which directly modulates these PMC neurons to influence voiding behavior.