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Preliminary analysis of the discriminative stimuli induced by the calcium channel “agonist” BAY K 8644

Rats were trained in a drug discrimination paradigm to press one of two levers for food reward after injection of the racemic dihydropyridine (DHP) Ca2+ ‐channel activator BAY K 8644 (2.5 mg/kg) and to press the other after vehicle injection. The discrimination was reliably attained in an average of 48 sessions. Thereafter, tests with various doses of BAY K 8544 yielded a dose‐dependent selection of the BAY K 8644 lever, with an ED50 of 0.74 mg/kg. The (−)‐enantiomer of BAY K 8644 generalized dose‐dependently (ED50 = 1.04 mg/kg), while the (+)‐enantiomer showed no generalization up to 10 mg/kg. Furthermore, nifedipine pretreatment fully antagonized the BAY K 8644 stimulus. These data indicate that BAY K 8644 produces physiological effects that can readily serve as discriminative stimuli in rats. The results also support the mediation of the BAY K 8644 stimulus through agonistic interaction with the calcium channel DHP receptor.