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The re-emerging threat of Zika virus: what you need to know

The Zika virus (ZIKV) is a single-stranded RNA virus of the family Flaviviridae and genus Flavivirus. It predominantly circulates in wild primates and arboreal Aedes mosquitoes, which primarily transmit the virus to man. It is closely related to dengue, yellow fever, Japanese encephalitis, and West Nile viruses. Zika fever or Zika virus disease (ZVD) is often described as a mild or inapparent dengue-like disease. However, with the explosive Brazilian epidemic of microcephaly and reports of Guillain-Barré syndrome, the current outbreak of ZVD being experienced in the Americas has reawakened us to the global public health threat of yet another re-emerging arbovirus infection.