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Anisotropy of the slope of ultrasonic attenuation in formalin fixed human myocardium.

Clinical implementation of quantitative ultrasonic tissue characterization is likely to require imaging the heart with sound propagating at varying angles relative to the fibers of the heart. Under these circumstances, the variation of the ultrasonic properties of myocardium with the angle of propagation relative to the myofibers may represent a significant source of potential misinterpretation. In the present study, the systematic approach of assessing the impact of anisotropy on quantitative myocardial tissue characterization is extended by reporting results of a recent in vitro study to measure the anisotropy of the slope of ultrasonic attenuation in specimens of formalin fixed human myocardium. Data obtained from regions of remote infarct are presented and compared to data acquired from regions identified to be free of infarct. The slope of attenuation for both regions exhibit a sinusoid-like dependence on angle that is approximately doubled for propagation parallel to the fibers as compared to perpendicular. These results are, in turn, compared to an earlier study from the laboratory that examined the effects of myocardial infarction on ultrasonic attenuation and interstitial collagen content in freshly excised canine hearts. Discussion regarding the analysis and interpretation of measurements of slope of attenuation is presented as well as a discussion of the possible influence of formalin fixation on our results.