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Chronic Glucagon Administration Enhances Intestinal Transport in the Rat 1

Summary Hyperglucagonemia, induced experimentally in rats by 6-hourly injections of glucagon, resulted in increased intestinal transport of amino acids and sugar as measured by the everted ring technique. Glucagon administration enhanced both accumulation and rate of uptake into the intestinal rings. The effect was observed after a lag of 2 days and increased thereafter with the length of treatment. Glucagon added in vitro was without effect. This experimental system, like diabetes and partial starvation, provides a technique for studying the effect of relative or absolute hyperglucagonemia on the intestine.