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Multiple myeloma and diagnostic imaging.

Multiple myeloma is the most common primary bone cancer among U.S. adults aged 70 years and older, and the incidence of the disease is increasing. Despite significant advances in treatment since the 1960s, multiple myeloma remains a challenging disease to diagnose and treat. Several medical diagnostic imaging examinations play important roles. This article reviews the biological basis of multiple myeloma, clinical features and diagnosis of the disease, and imaging and treatment protocols. The article also discusses unusual presentations of multiple myeloma.