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Stimulation and Suppression of Erythropoiesis in the Plethoric Mouse by Cyclic Nucleotides 1

Summary The cyclic 3,5-guanosine nucleotide and its dibutyryl derivative failed to enhance erythropoiesis in the posthypoxic mouse. This inhibition seemed to be competitive in that cGMP or dbcGMP, when administered in conjunction with dbcAMP, an erythropoietic stimulant, significantly decreased the percent 59Fe incorporation below the level of dbcAMP effect alone.