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Asia‐Pacific Journal of Clinical Oncology Cochrane Highlights

Background Non-rhabdomyosarcoma soft tissue sarcomas are a group of rare cancers. People with inoperable or metastatic disease have a poor prognosis. It was believed that higher doses of chemotherapy might improve patients’ survival. However, high doses of chemotherapy stop the production of blood cells in the bone marrow and are not compatible with life. Stem cells collected from people before high-dose chemotherapy can be transplanted back to the patient if the blood cell count gets too low. Due to a lack of research studies, it has not been proven that patients treated with this procedure live any longer than patients treated with standard chemotherapy. We wanted to determine whether using high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation was better or worse than standard-dose chemotherapy.