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Study of the Mutagenic Activity of Extracts of the Plant Wilbrandia ebracteata

The present study was carried out to investigate the mutagenic activity of six extracts of the plant Wilbrandia ebracteata (family Cucurbitacea), one of the species found in products commercially sold as "Taiuiá'. The method for investigation was the Salmonella/microsome assay using strains TA100, TA98 and TA102 in assays carried out in the presence or absence of S9Mix as the activating system. The results indicate the absence of mutagenic activity in flavonoid and cucurbitacin‐rich fractions. Signs of an increased mutagenic index were detected in the methanol fractions prepared from dried roots. We observed an increased dose response below a revertant rate, which was twice the spontaneous yield.