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Four‐Day, Twice Daily, Quadruple Therapy with Amoxicillin, Clarithromycin, Tinidazole and Omeprazole to Cure Helicobacter pylori Infection: A Pilot Study

Background. The best regimen for the treatment of Helicobacter pylori infection has yet to be defined. Four‐day quadruple therapy with tetracycline, metronidazole, bismuth, and a proton pump inhibitor has been shown to obtain a very high cure rate. However, the fact that it must be taken four times daily may interfere with compliance. The objective of the study was to test the efficacy and tolerability of a new 4‐day therapy with 4 drugs taken every 12 hours to cure H. pylori infection.