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[The effect of iron on globin chain synthesis during the first six months of extrauterine life (author's transl)].

The mechanism regulating the formation of the globin-chains of hemoglobin is unknown. We have examined the formation of the alpha-, beta- and gamma-chains during the first 6 months in 10 healthy infants. Immediately after birth the ratio between rates of synthesis of alpha- and non-alpha-chains was 0.94 +/- 0.16. At 6 weeks the ratio was alpha/gamma + beta = 1.22 +/- 0.29. After oral therapy with iron (2 mg/kg) between ages 3 and 6 months the ratio alpha/gamma + beta became 0.92 +/- 0.14. Whether the imbalance at 6 weeks is due to a depression of alpha-chain synthesis or to a stimulation of gamma-chain and beta-chain synthesis remains unclear. Possibly in infants without iron therapy the gamma-chain synthesis is stimulated as was suggested by the comparison of the gamma/beta ratios in infants with and without iron therapy.