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Profiles of serological reactions following adult cow inoculation with standard dose Brucella abortus strain 19 vaccine.

Experimental use of the standard dose (4-12 X 10(10) viable organisms per dose) Brucella abortus strain 19 vaccine (S19) in adult cattle led to a serological response in the complement fixation test (CFT) within 2 weeks. The antibody titres recorded could not be distinguished from those arising from infection for a period of 6-11 months. This was in the absence of the booster effect of Brucella antigen from either field or vaccine strains. The illegal or unintentional use of S19 in adult cattle may be recognized by a sudden steep antibody titre response in the CFT which will decline to negative levels within 6-11 months provided no booster Brucella antigen is present.