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Effects Of Tachykinin Receptor Agonists And Antagonists On The Guinea‐Pig Isolated Oesophagus

1. Vagal nerve stimulation of the guinea‐pig isolated oesophagus produced a triphasic tetrodotoxin (TTX)‐sensitive contractile response. The third phase, which was resistant to ganglion blocking drugs, was selectively abolished by capsaicin, suggesting the involvement of one or more neuropeptides released from afferent neurons. Receptors on cholinergic neurons were subsequently activated because the response was atropine sensitive. Contractile responses resulting from exogenous substance P were abolished by atropine and TTX and enhanced by physostigmine. These findings suggest that the third phase may be mediated by the action of a substance P‐like neuropeptide released from sensory nerve endings that subsequently activated cholinergic neurons.