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Recent Progress and New Perspectives in Studying T Cell Responses to Allografts

Studies in the past decade advanced our understanding of the development, execution and regulation of T‐cell‐mediated allograft rejection. This review outlines recent progress and focuses on three major areas of investigation that are likely to guide the development of graft‐prolonging therapies in the future. The discussed topics include the contribution of recently discovered molecules to the activation and functions of alloreactive T cells, the emerging problem of alloreactive memory T cells and recently gained insights into the old question of transplantation tolerance.