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Differences Between Epileptic and Non‐Epileptic Children with Special Reference to the Tryptophan Tolerance Test

A wide variety of clinical and laboratory tests were given to 90 children, 43 of whom were epileptics. Urinary xanthurenic acid excretion after a standard tryptophan load was determined in 80 children. Abnormal excretion rates occurred not only in the epileptics but also in children with other CNS disorders, as well as in some clinically healthy control siblings of epileptics. Among epileptic children the tryptophan tolerance test result was significantly more often abnormal when the child had a family history of seizures.