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Medical treatment of prostatic obstruction. An objective assessment.

Thirteen men suffering from prostatic obstruction were treated with an 8-week course of intramuscular injections of prostatic extract. Nine of these men had preliminary and subsequent evaluations of detrusor function and outflow obstruction by means of pressure/flow studies. Improvement in symptoms and measurements were only minimal and occurred in less than one-half of the cases. The greatest increase in flow rate recorded prostatectomy and no significant changes resulting from the injections could be seen on the histologic sections of their glands. These results did not confirm previous reports recommending this form of treatment for prostatic obstruction.