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Association of Glycemic Control and Cell Stress With Telomere Attrition in Type 1 Diabetes

Association of Glycemic Control and Cell Stress With Telomere Attrition in Type 1 Diabetes Hyperglycemia and abnormal blood glucose levels induce oxidative stress, promote the development of microvascular and macrovascular complications,1 and may increase telomere loss in patients with type 1 diabetes.2,3 All studies of adults with type 1 diabetes, except one, report a shorter telomere length associated with age, duration of type 1 diabetes, and higher glycated hemoglobin A1c (HbA1c) levels.4 To expand these data in a pediatric population at the onset of type 1 diabetes by assessing the association between telomere length and age or HbA1c level,5 we conducted a retrospective longitudinal study evaluating the association of glycemic control and associated cell stress with telomere dynamics during a 7-year follow-up.