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SPRINT to reach BP goals: The connections among hypertension, cognition, and brain health.

Alzheimer disease is now the sixth leading cause of death in the US and is increasing in epidemic proportions internationally. While there are many diverse etiologies, hypertension is second only to age as the most signifi cant risk factor contributing to cognitive decline and the progression of dementia. Hypertension control is a known intervention to reduce cardiovascular risk, but could hypertension control reduce the risk of mild cognitive decline and dementia as well? The Systolic Blood Pressure Intervention Trial (SPRINT) Research Group revealed that intensive BP control over 3.26 years signifi cantly reduced the risk of mild cognitive impairment, a precursor stage of dementia.