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Incidence and prevention of deep venous thrombosis occurring late after general surgery: randomised controlled study of prolonged thromboprophylaxis.

OBJECTIVE
To study the incidence of late deep venous thrombosis (DVT), and to evaluate a regimen of prolonged thromboprophylaxis after general surgery.


DESIGN
Randomised, controlled, open trial, with blinded evaluation.


SETTING
University hospital, Denmark.


SUBJECTS
176 consecutive patients undergoing major elective abdominal or non-cardiac thoracic operations, of whom 118 were eligible for evaluation.


INTERVENTIONS
Thromboprophylaxis with a low-molecular-weight heparin, tinzaparin, given for four weeks (n = 58), compared with one week (control group, n = 60).


MAIN OUTCOME MEASURES
Presence of DVT established by bilateral venography four weeks after the operation.


RESULTS
The incidence of late DVT in the control group was 6/60 (10%, 95% confidence interval (CI) 4% to 21%). In the prophylaxis group it was 3/58 (5.2%, 95% CI 1% to 14%) (p = 0.49).


CONCLUSION
Prolonged thromboprophylaxis had no significant effect on the incidence of DVT occurring late after general surgery.