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CLINICAL EVALUATION OF y-SEMINOPROTEIN (y-Sm) IN BENIGN PROSTATE HYPERTROPHY

The levels of serum y-seminoprotein (y-Sm) and prostatic acid phosphatase (PAP) were determined by enzyme immunoassay using an EIA y-Sm test kit and radiommunoassay using a RIA PAP test kit in 205 patients with clinically diagnosed benign prostate hypertrophy (BPH). A y-Sm level of over 4.0ng/ml and a PAP level of over 3.0 ng/ml were considered to be high. A high level rate of y-Sm was seen in 12.2% of the BPH patients (25 out of 205 patients), and 15 of these patients were histopathologically diagnosed BPH. 20 of the remaining 180 patients whose y-Sm level was normal received transurethral resection of the prostatic gland (TUR-P), and incidental prostatic carcinoma was found in 3 patients. Transrectal prostatic longitudinal ultrasonography by linear array was performed in 25 y-Sm positive patients (A group) and in 20 y-Sm negative patients who who had received TUR-P (B group). As a result, prostatic stones were found in 60% in A group and 35% in B group, and prostatic abscess was observed in 32% in A group and 10% in B group. When the weight of the prostate was computed using ultrasonography, the mean prostatic weight was 30.8g in A group and 23.9g in B group. The y-Sm level tended to be high in patients with large BPH and BPH patients with prostatic stones and/or prostatic abscess. These data suggested that transrectal prostatic sonography was useful for y-Sm positive patients.