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Noradrenaline‐Induced Inhibition of Voltage‐Sensitive Calcium Currents in NG108‐15 Hybrid Cells

The effect of noradrenaline (NA) on voltage‐sensitive calcium currents in neuroblastoma × glioma hybrid (NG108‐15) cells has been studied using a whole‐cell clamp technique. NA inhibited calcium current. The EC50 for NA induced inhibition was 177 nM. The NA receptor involved had a similar pharmacological profile to α2 adrenoreceptors but did not respond to clonidine. NA inhibited calcium current by an amount which depended on both membrane potential and current amplitude. When current‐dependent inactivation of calcium current was maximal, NA was without effect. The data are consistent with a mechanism where NA enhances current‐dependent inactivation.