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Survey on microRNAs Targeting MuRF1 and MuRF2 in Regenerating Skeletal Muscle

Skeletal muscle is a very adaptable tissue, mainly due to its regenerative capacity, which is fundamental importance for repairing large lesions and microlesions as well. Recently our research group observed that the E3 ligases MuRF1 and MuRF2, in addition to being implicated the atrophy process is also essential for muscle regeneration (data not published). In view of these results, in this study we investigated the molecular mechanisms involved in the increased expression of MuRFs during regeneration. Our hypothesis contemplates that certain microRNAs (miRNAs or miRs, regulators of gene expression at post‐transcriptional level) can regulate MuRFs expression during the regeneration process.