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Development of "granulosa" cell tumors from intrasplenic testicular transplants in castrated ACI rats.

A day-old testis was transplanted into the spleen of one-month-old castrated ACI male rats. For the first six months, diffuse hyperplasia of the interstitial cells was conspicuous with progressive deletion of spermatogenic cells in the seminiferous tubules. Then multiple foci of hyperplastic nodules started to appear, mainly near the tunica albuginea, in all castrated rats, but never in noncastrated rats. These nodular tissues gradually fused together (so-called Leydig cell tumors) and at about 12 months, other distinct tumor foci, morphologically indistinguishable from ovarian granulosa cell tumors, developed in and replaced the nodular tissues. The specific binding of follicle stimulating hormone to the "granulosa" cell tumor tissues was demonstrated. The hypothesis is presented that Sertoli cells were involved in the hyperplastic nodules and ultimately gave rise to the "granulosa" cell tumors.