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[Evaluation of clinical and psychological methods in estimating antidepressants efficacy in treatment of depression (preliminary report)].

The aim of the study was to evaluate the onset of action of antidepressants using CGI i CGI Improvement, MADRS, Self Analogue Scale and Wiener Battery Test System. Onset of action of antidepressants was evaluated in a group of 18 patients with major depression. Evaluation was assessed at 4, 8, 10, 14, 28 days of treatment. Significant reduction of symptoms in MADRS at day 8 was the predictor of effect at day 28. Reduction of symptoms in MADRS was not correlated with improvement in cognitive functions. Most of the psychological tests showed to be not sensitive enough to estimate a change in cognitive processes under pharmacotherapy.