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Re‐evaluation of the L‐dopa loading effect on dopamine metabolism in rat striatum

Investigation by HPLC with electrochemical detection of dopamine (DA) metabolism in rat striatum after L‐dopa + benserazide treatment allowed quantification of the time course evolution of DA, 3,4‐dihydroxyphenylacetic acid and homovanillic acid levels. Furthermore, four peaks which did not appear in controls, were detected in treated striatum. One was identified as 3‐methoxytyrosine, the level of which was still high 9 h after treatment. 3‐Methoxytyrosine, has been detected previously in plasma of parkinsonian patients treated with L‐dopa, and the disturbance in DA metabolism could explain some of the side‐effects induced by that treatment.