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Does NSAID use increase the risk for decline in renal function in patients with chronic kidney disease?

Regular-dose NSAID use does not increase the risk of chronic kidney disease (CKD) progression and progression to end-stage renal disease (ESRD) in mixed populations that include patients with normal renal function to those with CKD 3. However, high doses of NSAIDs are significantly associated with an increased risk of CKD progression in this mixed group (SOR: B, systematic review of observational studies and cohort study). Over an 11-year period, chronic NSAID use is associated with progression to ESRD in patients with established CKD (SOR: B, large observational cohort study). Copyright © 2019 by Family Physicians Inquiries Network, Inc. DOI 10.1097/EBP.0000000000000470