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HLA‐B*5801: a genetic susceptibility to allopurinol‐induced DRESS

A 40-year-old Chinese man presented to our hospital complaining of a non-itchy rash 5 weeks after he had commenced taking allopurinol 100mg daily, prescribed by his general practitioner for gout. The rash, involving his back and limbs, began to appear 2e3 weeks after starting allopurinol, with associated fevers, arthralgia and back pain. The patient denied having any rash or pain in his mouth. He had no history of recent overseas travel, unprotected sexual intercourse or intravenous drug use. He denied experiencing any vomiting, diarrhoea or abdominal pain. The patient’s background medical history included hypothyroidism. His baseline renal function was normal. His current medications were: allopurinol, 100mg daily; thyroxine, 100μg daily; and paracetamol, 1 g four times daily (as required) for back pain. He had no known allergies.