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RP 59500 postantibiotic effect defined by bacterial ultrastructure.

Staphylococcus aureus was exposed to 0.3 microgram/ml RP 59500, an injectable streptogramin, 0.75 minimum inhibitory concentration (MIC) for six hours, washed, resuspended in fresh medium and incubated for ten hours. The postantibiotic effect (PAE) was determined by growth kinetics and by bacterial ultrastructure. The PAE was eight hours when determined by changes in the cell diameters and three hours when determined by the count of colony forming units (CFU).