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LIVER METASTASES FROM COLORECTAL CANCER WERE MORE SUSCEPTIBLE TO COVID-19

Background: Coronavirus diseases 2019 (COVID-19) are severe and prevalent diseases all over the world, which have caused more than 10 million infections and more than half million deaths so far Angiotensin I-converting enzyme 2(ACE2) and transmembrane serine protease 2 (TMPRSS2) are the entry receptors that play crucial roles in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19 Due to the high expression of ACE2/ TMPRSS2, and the immunosuppression caused by cancer and anti-cancer therapy, cancer patients are more likely to be infected with SARS-CoV-2 Previous studies have showed that the high expression of ACE2/TMPRSS2 in lung cancer, tongue cancer and colorectal cancer may be related to the high susceptibility of SARS-CoV-2 However, the susceptibility of liver metastases has not been elucidated Methods: We explored the Gene Expression Omnibus(GEO) database to mine the datasets of liver metastases from colorectal cancer with matched normal liver R package limma was used to analysis the datasets Paired t-test was used to compare the expression of ACE2 and TMPRSS2 between groups Results: GSE38174 dataset of 90 cases was enrolled to compare the expression levels of ACE2 and TMPRSS2 in liver metastases, matched liver Halo of metastases and normal liver The results showed that ACE2 expression in liver metastases was higher than that in liver Halo of metastases and normal liver (3 303±0 426, 2 328±0 228 and 2 522±0 173;metastases vs Halo, p=0 016;metastases vs normal, p=0 065;and Halo vs normal, p=0 272;Figure A) The expression of TMPRSS2 in liver metastases was significant higher than that in liver Halo or normal liver (3 006±0 258, 2 511±0 118 and 2 409±0 129;metastases vs Halo, p=0 075;metastases vs normal, p=0 027;and Halo vs normal, p=0 250;Figure B) Conclusion: Liver metastases have a high-expression of ACE2 and TMPRSS2, which may make patients more susceptible to SARS-CoV-2 infection In addition, liver metastases could serve as a target of SARS-CoV-2, casing liver damage and virus replication and transport However, as the first study on the genetic susceptibility of liver metastases to SARS-CoV-2 from public databases, our research needs to be further verified with real-world data Abbreviations: ACE 2: angiotensin I-converting enzyme 2;COVID-19: coronavirus diseases 2019;GEO: Gene Expression Omnibus;SARSCoV- 2: severe acute respiratory syndrome coronavirus 2;TMPRSS2: transmembrane serine protease 2