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Alteration of Template Activity of Chromatin from Livers of Pneumococcus-Infected Mice 1

Summary The template activity of mouse liver chromatin is elevated when examined 5 hr after infection of the animal with D. pneumoniae. At 14 hr, the activity falls below control values. These changes demonstrate an early influence of generalized infection on the control of transcription in the liver. Infected, adrenalectomized mice do not respond with the early rise in chromatin template activity, suggesting the role of glucocorticoid mediation. It is proposed that these changes in transcription characteristics are related to changes known to occur in protein synthesis during the course of bacterial infection.