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Study on resistance of extended spectrum beta lactamase produced by escherichia coli to antibiotics

AIM To investigate the production rates of extended spectrum beta lactamase (ESBL) and its resistance to antibiotics among escherichia coli(E.coli) isolated from clinical specimens and provide a rational guide for the administration of the antibiotics.METHODS ESBL and susceptibility to antibiotics were measured by K B paper disk diffusion,E test and VITEK microbe auto analysis instrument. RESULTS There were 21 strains producing ESBL among 124 E.coli strains. The production rate of ESBL was 16.9%. Among 19 kinds of antibiotics, the drug resistant rates of strains producing ESBL to cefoperazone/sulbactam, Imipenem were 4 8% and 9.6% respectively; that of ceftazidim, cefoxitin and amikacin were 23.8%. The drug resistant rates to the rest of the 19 antibiotics were 66.0%～100.0%. CONCLUSION The drug resistance of ESBL produced by E.coli strains to most of the antibiotics generally in use was significantly high, which is worthy of attention and alarm. It is suggested by the authors that Imipenem and cefoperazone/sulbactam be first considered and chosen in the treatment of ESBL produced by E.coli infection.