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INGESTION OF POLYCHLORINATED BIPHENYLS ON THE RAT

A b s t r a e ~ A r o c l o r 1242, a commercial polychlorinated biphenyl mixture, was fed to rats at dietary levels of 0, 5 and 25 ppm for 2, 4 and 6 months. Significant elevations of urinary coproporphyrin excretion, hepatic lipid and hepatic microsomal-hydroxylase activity were observed in rats ingesting 25 ppm for 2 months. In rats given the 5 or 25 ppm regimens for 4 or 6 months, urinary coproporphyrin excretion and liver weight, lipid content and microsomal-hydroxylase activity were higher than in controls. Histopathological examination revealed lipid vacuolation and proliferation of smooth endoplasmic reticulum in the hepatocytes of treated animals. These findings indicate that long-term, low-level ingestion of Aroclor 1242 may result in changes in a variety of biological parameters.