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Significance of carbon monoxide pulmonary partial ductances and transbronchial lung biopsies during evolution of interstitial lung diseases.

Among 80 patients with suspicion of interstitial lung disease (ILD), we studied the significance of carbon monoxide (CO) partial ductances with special reference to arterio-alveolar partial ductances (DuaCO), for diagnosis and follow-up of 63 of them. The results of DuaCO were compared to histologic and radiologic data, in 40 patients with abnormal X-ray findings (interstitial lesions) and in 23 patients with normal X-ray findings. In patients with abnormal X-ray findings there is a statistical correlation between decrement of DuaCO and existence of histologic interstitial lesions (p < 0.001). In patients with normal X-ray findings but a risk of interstitial injury, there is also a statistical relation between alteration of DuaCO and existence of histologic interstitial lesions (p < 0.02). DuaCO seems to be closely linked to trophicity of the pulmonary interstitium and is proposed as a functional index to follow up ILD.