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How to Grab a Membrane

After endocytosis, endosomes fuse with one another. One targeting factor appears to be the production of phosphatidylinositol 3-phosphate in membranes; this lipid head group is then recognized by so-called FYVE domains found on some endosomal fusion proteins. Kutateladze and Overduin present an analysis of the structure of the FYVE domain of early endosome antigen 1 in complex with phosphatidylinositol 3-phosphate and suggest a mechanism by which these interactions may promote endosome recognition. For an excellent overview on how FYVE domains function in signaling, read the STKE perspective by Corvera. T. Kutateladze, M. Overduin, Structural mechanism of endosome docking by the FYVE domain. Science 291, 1793-1796 (2001). [Abstract] [Full Text] S. Corvera, Signal transduction: Stuck with FYVE domains. Science's STKE (2000), http://stke.sciencemag.org/cgi/content/full/OC_sigtrans;2000/37/pe1 [Full Text]