{'fraction_non_alphanumeric': 0.0525, 'fraction_numerical': 0.0125, 'mean_word_length': 5.068181818181818, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Deletion Polymorphisms in the Promoter Region of Fcγ Receptor IIB Is Not Associated with Antigen‐Specific IgG2a and IgG2b Antibody Responses in NC/Nga Mice

Fcγ receptor (R) IIB, a low‐affinity FcR for IgG, inhibits B cell Ag R (BCR)‐mediated activation when these two receptors are cross‐linked by Ag and IgG‐containing immune complexs (ICs). We found deletion polymorphisms in the promoter region of fcgr2b in NC/Nga mice, a model for human atopic dermatitis. NC/Nga mice produced significantly higher levels of ovalbumin (OVA)‐specific IgG, IgG2a and IgG2b than did BALB/c mice. Analysis of (BALB/c×NC/Nga)F1×BALB/c or (BALB/c×NC/Nga) F1×NC/Nga backcross mice revealed that deletion polymorphisms of fcgr2b in NC/Nga mice does not directly regulate hyper OVA‐specific IgG2a and IgG2b Ab responses.