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EVALUATION OF THE ABORTIFACIENT AND ESTROGENIC ACTIVITY OF CICER ARIETINUM LEAVES ON FEMALE ALBINO RAT

There is a growing demand for the discovery of new phytoestrogens to be used as safe and effective hormonal replacement therapy. Cicer arietinum is an indigenous herb found abundant in India. It is traditionally being used as an abortifacient. Aqueous, alcoholic and chloroform extract of this herb were tested for abortifacient activity in female albino rat from day 11 to 15 of pregnancy at the dose level of 100, 200 and 400 mg/kg body weight. The aqueous extract at a dose of 400mg/kg was found to be most effective in causing significant abortifacient activity. Similarly it was also found to increase the reproductive organ weight and possess estrogenic activity when tested in immature ovariectomised female albino rats suggesting the antifertility activity of the extract.