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An improved algorithm for the design of individually optimized dialysis profiles

An efficient algorithm for the optimization of process parameters during dialysis has been developed. It is possible to compute optimal concentrations of electrolytes in dialysis by solving a tracking problem for distinguished dynamic variables, which are indirectly influencing the status of the patient and can directly be modelled. The tracking problem was treated as a dynamic optimization problem, which has been solved by the application of a modified continuous descent procedure, which is known from the theory of unconstrained static minimization. The used method is characterized by its simple mode of application, short solution time and moderate storage need. Especially in cases of contradictional requirements for the desired time courses of a dialysis session the used method performs well.