{'fraction_non_alphanumeric': 0.020061728395061727, 'fraction_numerical': 0.009259259259259259, 'mean_word_length': 5.240384615384615, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
MEF2C Silencing Attenuates Load‐Induced Hypertrophy and Energetic Metabolism in Mice Left Ventricle

Aim: Myocyte enhancer factor 2C (MEF2C) transcription factor has been suspected to play a critical role in coordinating the proper response of cardiac myocytes to hypertrophic stimuli. However, a better understanding of the role of MEF2C in cardiac hypertrophy has been hampered by the fact the loss‐of‐function models of MEF2C in the heart do not survive to adult life. In the present study, we used an interference RNA strategy to investigate the role of MEF2C in the hypertrophic growth induced by pressure overload in mice left ventricle (LV).