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Brain‐Derived Neurotrophic Factor and Peripheral Nerve Regeneration: A Functional Evaluation

The potential benefit of brain‐derived neurotrophic factor (BDNF) on motor‐nerve regeneration after transection injury in 24 adult rats was evaluated after entubulation repair. Gait analysis for ankle angle and tension transduction device (TTD) strain‐gauge measurements yielded functional evaluation of regeneration. The BDNF (15 mg/mL) or phosphate buffered saline(control) was injected into the silicone elastomer (Silastic®) channel. Gait analysis performed 0, 2, 4, 6, 10, and 12 weeks after injury demonstrated a significant difference between uninjured and injured legs of 23 and 43 degrees, respectively (P<.001, analysis of variance). The TTD evaluation 13 weeks after injury demonstrated a significant decrease in force development of injured compared to uninjured legs, 148 and 58 g, respectively (P<.001). No functional benefits were demonstrated between BDNF‐treated versus control‐treated animals in either model for a single exposure to BDNF.