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FRI0485 TIMED UP AND GO TEST FOR VERTEBRAL FRACTURE PREDICTION

Background Sarcopenia describes the age related loss of skeletal muscular mass and function. The development of sarcopenia may confer an increased risk of falls which leads to a potential increase in fracture. The Timed Up and Go (TUG) Test is one of clinical tools used to assess sarcopenia. Objectives We hypothesized that slow TUG test performance would predict vertebral fracture (VF) in post-menopausal women independently of bone mineral density (BMD) and other risk factors. Methods This is a cross sectional study enrolled from September 2018 to December 2018, including post-menopausal women referred to rheumatology department for measure of BMD. All subjects underwent dual energy X-ray absorptiometry (DeXA) and physical performance tests including the TUG test. TUG performance was considered low if it took, 15 seconds or longer. A vertebral fracture assessment (VFA) image was obtained which was subsequently scored for the presence of significant vertebral deformities. VF grade 1 were excluded. Results Eighty four patients were included. The mean age of our patients was 62.29±8.27 years with an average body mass index (BMI) of 31.45±6.21 kg/m2 [18.18-44.38]. According to the WHO classification 42 patients (50%) had osteoporosis. Among 84 women, 47 had a low TUG performance. Subjects with low TUG performance had an older age (57.94 vs 65.71 years) (p<0.001), and had a significantly lower BMD at femoral neck (0.825 g/cm3vs 0.752 g/cm3) (p<0.001). There was no significant difference between the two groups regarding duration of menopause, history of previous fragility fracture, body mass index and BMD at total hip and at vertebral site. Osteoporosis was found in 30 patients who had low TUG performance and in 12 patients who had normal TUG performance without statistically significant difference (p=0.08).VF were assessed in 22 subjects. VF were found in 20 patients with low TUG performance (42.55%). Compared with the group with normal TUG performance, subjects with low TUG performance had significantly higher number of fracture (p<0.001).A significant correlation was found between the number of VF and the score of get up and go test (Khi-2 test, p<0.001). Conclusion Our study found a strong relationship between TUG performance and prevalent vertebral fracture. Therefore evaluation of additional risk factors may improve the prediction of vertebral fracture in post-menopausal women. Disclosure of Interests None declared