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Plasma binding of imipramine and clinical outcome.

The binding of imipramine to plasma protein was examined in 26 depressed patients. In contrast to the findings of previously published reports, the fraction of the drug that remained unbound was found to vary significantly from one patient to another. This finding provides a possible explanation for the discrepancies that have been found in studies that have attempted to correlate plasma levels of antidepressant drugs and clinical outcome.