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[Serum levels of luteinizing hormone, testosterone and prolactin in patients with septic shock].

Many studies show important disturbances in hormonal balance in patients with severe sepsis. There are a lot of factors, which are involved in this process but the role of sex steroid hormones is unknown; especially, the role of testosterone, which is one of the anabolic hormones and a immune function modulator. We hope that sex steroid hormone mechanisms of action recognition in septic shock may help in treatment of such patients. The aim of this study was to evaluate changes in sex hormone concentrations in septic patients and their prognostic significance. We studied serum level of luteinizing hormone (LH), testosterone (T) and prolactin (PRL) in 20 patients with septic shock and in healthy male volunteers (n = 20). Septic patients were divided into two groups: survivors (group I, n = 10) and nonsurvivors (group II, n = 10). We noticed significant decrease of testosterone and LH serum levels in septic group vs the controls and correlation between T and LH serum levels and survival. Acute lung injury was associated with higher PRL serum level and was independent from the LH and T serum level. We also noticed incorrect pituitary down-regulation of testosterone secretion. Our study showed that sex steroid hormones can be good prognostic factors of survival and complications of septic shock.