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Simultaneous ATP-AET-serotonin protection of spermatogonia from mutations induced by 300 R x-rays in the mouse.

SummaryProtection of spermatogonia from dominant lethal mutations induced by acute whole-body X-irradiation (300 R) was studied in C57BL mice given a simultaneous injection of AET, ATP and serotonin. Evidence was obtained that simultaneous administration of these radioprotectors significantly reduced dominant lethality. Expected and observed rates of post-implantation loss were found to be of the same order of magnitude.