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Development and in vitro Evalution of Guar Gum based Fluconazole in situ Gel for Oral Thrush

The objective of the present study was to prolong the delivery of the active drug in the oral cavity using a suitable carrier such as in situ gel which can effectively deliver the drug for an extended duration of time hence not only reduce the systemic side effects but also improve the therapeutic efficacy, patient compliance. Buccal drug delivery systems are better suitable for antifungal drugs particularly for oral thrush. The viscosity of in situ system was found to be in the range (49 to 75 cps) for the sol, whereas for the gels it was up to (17000 cps). The maximum gel strength and mucoadhesion was found to be up to (98 seconds) and (85.99 dynes/cm) respectively. The in vitro drug release of both the formulations G13 and G14 released 85.3%, whereas the formulations G3 and G4 released 89.40% and 89.10% respectively at 8 hour. More over to comprehend the drug release mechanism the data were fitted in to korsmeyer -peppas exponential model where the ‘n’ values were in the range of 0.06 to 0.113. It was understood that G code formulation were following predominantly first order and fickian diffusion mechanism of drug release .Different techniques, FTIR spectroscopy and differential scanning calorimetry (DSC) were used to estimate the incompatibility.