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CHARACTERISATION OF NF‐KB ACTIVATION IN REGENERATING FIBRES OF OLD MICE

Sarcopenia is the age‐related loss of muscle mass and function. In human studies a decrease of up to 50% in muscle mass and function is observed from the ages of 25 to 70 years and this contributes significantly to frailty and loss of independence in the ageing population. An increase in pro‐inflammatory cytokines is associated with many age‐related conditions including sarcopenia (particularly TNF‐alpha and IL‐6). Many inflammatory processes are under the direct influence of the NF‐κB pathway and a chronic activation of NF‐κB has been shown in muscles from old mice and in accelerated models of muscle ageing (eg. Vasilaki et al, 2006). Additional studies using immunofluorescent antibody staining demonstrated the presence of p65 (a subunit of NF‐κB) only in muscle fibres containing centrally located nuclei, suggesting that NF‐kB was only active in regenerating muscle fibres.