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MO058PREDICTORS OF MORTALITY IN PATIENTS WITH NEPHROBLASTOMA: A SYSTEMATIC REVIEW AND META-ANALYSIS


 
 
 Nephroblastoma constitutes 90-95% of the 5 types of kidney tumors that are most common in children. Studies for clinical management of patients with nephroblastoma are continuing today and several factors are thought to influence the mortality. This study is aimed to evaluate the outcome of patients with nephroblastoma and its associated factors.
 
 
 
 The dataset was defined by searching PubMed, EMBASE, Google Scholar that had been published until December 2020. No language or date restriction was performed during literature searching. The meta-analysis was conducted using Review Manager Software version 5.4. Factors investigated included gender, age, and site of tumor with p <0.05 considered significant.
 
 
 
 The final analysis was conducted on 5 studies, and 2 were multi-institutional. Overall, 17279 patients with nephroblastoma were included in this study. The pooled data demonstrate there was significant difference in the mortality incidence of nephroblastoma patients with gender, (OR=1.25 [1.02, 1.52], p=0.03). Significant difference result was also seen in the incidence of mortality with age (OR=2.05 [1.86, 2.26], p<0.00001). There was no association in the mortality of nephroblastoma patients with site of tumor (OR=1.28 [0.79, 2.09], p=0.31). No publication bias was found in our study.
 
 
 
 The incidence of mortality in nephroblastoma patients still has to be a concern in patient management. Gender and age are factors that associate with incidence of mortality in nephroblastoma patients.
