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Family History of Inflammatory Bowel Disease Among Patients with Ulcerative Colitis: A Systematic Review and Meta‐Analysis: P‐77

postoperative use of anti-TNF biologics (16.7% vs. 7.9%, P 1⁄4 0.002) than the adults. Pouch failed in 100 patients (7.8%) after a mean follow-up of 10.666.8 years, including 13(12.0%) in the pediatric group and 87 (7.4%) in the adult group (P 1⁄4 0.082). Risk factors for pouch failure in the multivariate analysis included preoperative use of anti-TNF biologics, postoperative use of anti-TNF biologics, Crohn’s disease of pouch, pouch surgery-related complications and postoperative pouch-associated hospitalization. However, pediatric patients were not found to be significantly associated with pouch failure in neither the univariate nor multivariate analyses, with a hazard ratio of 0.67 (95% confidence interval: 0.36-1.24, P 1⁄4 0.2) from the multivariate analysis. CONCLUSION(S): Pediatric patients suffered from a higher incidence of postoperative pouch complications than adults; however the long-term pouch retention rates were comparable.