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Patients with Malignant Glioma CD 4 Compartment Explains Cellular Immune Defects in Increased Regulatory T-Cell Fraction Amidst a Diminished

Immunosuppression is frequently associated with malignancy and is particularly severe in patients with malignant glioma. Anergy and counterproductive shifts toward TH2 cytokine production are long-recognized T-cell defects in these patients whose etiology has remained elusive for >30 years. We show here that absolute counts of both CD4 T cells and CD4CD25FOXP3CD45RO T cells (Tregs) are greatly diminished in patients with malignant glioma, but Tregs frequently represent an increased fraction of the remaining CD4 compartment. This increased Treg fraction, despite reduced counts, correlates with and is sufficient to elicit the characteristic manifestations of impaired patient T-cell responsiveness in vitro . Furthermore, Treg removal eradicates T-cell proliferative defects and reverses TH2 cytokine shifts, allowing T cells from patients with malignant glioma to function in vitro at levels equivalent to those of normal, healthy controls. Such restored immune function may give license to physiologic antiglioma activity, as in vivo, Treg depletion proves permissive for spontaneous tumor rejection in a murine model of established intracranial glioma. These findings dramatically alter our understanding of depressed cellular immune function in patients with malignant glioma and advance a role for Tregs in facilitating tumor immune evasion in the central nervous system. (Cancer Res 2006; 66(6): 3294-302)