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Preliminary clinical study of a new method of treatment of corneal burn defects

Purpose. Of the work is to compare the effectiveness of treatment of burn ulcers with canned amnion and amnion saturated with lysate of autologous platelet-rich plasma (PRP). Material and methods. To compare the effectiveness of treatment of canned amnion and lysate-soaked PRP, 10 patients with ulcers with an area of more than ½ of the cornea after fresh burns of 2–3 degrees aged from 26 to 53 were observed, divided into 2 equal groups. In the comparison group, the treatment of ulcers was carried out against the background of conservative treatment by covering the cornea with an amniotic membrane for 7 days, after which the amnion was removed and the condition of the cornea was monitored. If necessary, the procedure was repeated. In the experimental group, an amniotic membrane saturated with lysate of autologous PRP was used. The assessment of the condition of the cornea was carried out using clinical and instrumental studies, including visometry, biomicroscopy with fluorescein staining, photoregistration and OCT on the Heidelberg Engineering “OCT Spectralis” apparatus. Results. In patients of the experimental group, transplantation of an amniotic membrane impregnated with PRP lysate, in comparison with conventional amnion, led to epithelization of ulcers faster by an average of 7 days, the cornea remained more transparent, and visual acuity was higher by 0,17. Conclusions. The use of an amniotic membrane saturated with PRP lysate may be a promising method of treating corneal burn ulcers. Keywords: amnion; platelet-rich plasma; platelet lysate; corneal ulcers; corneal burns.