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Screening for ovarian cancer: progress and challenges

Introduction Ovarian cancer is one of the most aggressive gynaecological malignancies, the high mortality being a direct result of the advanced stage of the disease at the time of diagnosis. However, survival rates of greater than 90% have been reported with Stage I disease. Consequently there is considerable interest in the development of screening methods for the early detection of ovarian cancer. In the second of two reviews I discuss the challenges of screening for ovarian cancer, the screening tests that are available, the target populations and the screening trials currently in progress.