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Epigenetic suppression of potassium‐chloride co‐transporter 2 expression in inflammatory pain induced by complete Freund's adjuvant (CFA)

Multiple mechanisms contribute to the stimulus‐evoked pain hypersensitivity that may be experienced after peripheral inflammation. Persistent pathological stimuli in many pain conditions affect the expression of certain genes through epigenetic alternations. The main purpose of our study was to investigate the role of epigenetic modification on potassium‐chloride co‐transporter 2 (KCC2) gene expression in the persistence of inflammatory pain.