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O-17 The effect of thoracic epidural anaesthesia on diastolic function

hours. Additional analgesia was provided with meperidine (1 mg kg 1 i.m.) when needed. Pain relief was evaluated with VAS (0 no pain, 10 worst pain) just before the first injection (baseline), and at 15min, 30min, 1, 2, 3, 4, 6, 12, 18, 24, and 48 h thereafter. Sedation score (0 Awake and alert patient, 4 Deep sedation) was noted synchronously with the VAS score, and adverse effects (gastric discomfort, nausea, vomiting, hypotension, bradycardia, renal impairment) were noted when they were observed. Chi-squared test and Fisher’s exact test were used to compare occurrences between two groups. Non-paired Student’s t-test was used to compare measured data between the groups. P 0.05 was considered significant. Results: The two groups were similar in terms of demographic and surgical data. The base line VAS scores were similar in both groups. The VAS scores in the 15th min and 30th min were not different from baseline (P 0.05), whereas VAS scores of all other measurements were significantly lower than that of baseline values in both groups (P 0.05). These decreases were similar in both groups. The mean overall VAS scores were similar in both groups. We did not observe any adverse effect related to the study drugs in any patient. Laboratory measurements showed no evidence of renal damage in any group. Three patients (15%) in Group I, and two patients (10%) in Group II needed additional analgesic drug (P 0.05). Discussion: We conclude that pain after cardiac surgery may be treated with either diclofenac or lornoxicam. Further studies are required to asses the efficacy and safety of these drugs in postoperative analgesia for cardiac surgery patients. Reference: 1 Hynninen MS, Cheng DC, Hossain I, et al. Non-steroidal anti-inflammatory drugs in treatment of postoperative pain after cardiac surgery. Can J Anaesth 2000; 47: 1182–1187.