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Environmental reprogramming and molecular profiling in reconstitution of human hair follicles

The ability to synthesize an organ de novo is the ultimate goal of regenerative medicine. Given the difficulty, it is reasonable to first attempt tissue regeneration with a miniorgan, such as the hair follicle. Hair follicles (HF) undergo physiologic cyclical regeneration and cellular components exhibit robust regenerative capabilities (1, 2). The molecular biology of HF stem cells and their niche has been well characterized and scientists are poised to make progress (1). In PNAS, Higgins et al. discuss several unique findings regarding de novo human hair folliculogenesis (3). The authors show that human scalp dermal papillae (DP), cultured in 3D, can induce hair from foreskin and identified gene candidates that may contribute to the DP phenotype.