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Human cutaneous microvascular ageing: potential insights into underlying physiological mechanisms of endothelial function and dysfunction

Attenuated human blood vessel reactivity, and an attendant loss of nitric oxide, is an independent risk factor associated with increased cardiovascular mortality and may be the earliest pathological finding associated with cardiovascular disease. Furthermore, vascular dysfunction resulting from decreased NO bioavailability is a systemic disease process that occurs simultaneously in multiple vascular beds affecting both the resistance and conduit vasculature (Abularrage et al. 2005).