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Multi‐faceted brain changes associated with proximity to dementia onset: The PREVENT‐Dementia study

First‐degree relatives of people with dementia (FH+) are at increased risk of developing Alzheimer’s disease (AD). Identifying preclinical brain changes would facilitate both early quantifiable longitudinal disease monitoring and interventional trials. However, the literature of imaging changes in FH+ remains highly controversial. We aim to investigate “estimated years to onset of dementia” (EYOD) as a surrogate marker of preclinical progression and assessed whether FH+ approaching the parental age of dementia onset would express more severe patterns of longitudinal brain changes.