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Testis steroid sulfatase activity in rats treated with chorionic gonadotrophin.

Steroid 3β-sulfatase activity was assayed in rat testes after the in vivo injection of HCG (100 U/day) or with saline after 3 and 10 days. HCG was tested with hypophysectomized rats compared with sham operated controls but no differences in steroid sulfatase activities were observed. Steroid 17β-sulfate was not cleaved significantly by the testicular enzyme and HCG treatment was not effective in activating the enzyme with 17β-estradiol-17β-sulfate and testosterone sulfate as substrates. The cleavage of pregnenolone-3β-sulfate was observed to follow a biphasic response to HCG administration, with a decrease in cleavage activity after 3 days followed by a restoration of cleavage activity after 10 days of HCG treatment. From the small magnitude of enzyme response, it is apparent that testicular steroid 3β-sulfatase is not a primary locus of gonadotrophin control. Steroid sulfate contribution to the regulation of testicular steroid hormone formation is considered in terms of secretion and local product feed-b...