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Methohexitone and its application in dental anaesthesia.

The first report of the use of methohexitone intravenously in clinical practice was in 1956 (Gruber et al., 1956). The onset of anaesthesia was noted to be more rapid, the duration of anaesthesia for a given dose much shorter, and the patients on awakening were more alert than patients receiving thiopentone. In the following year there were three reports of its clinical use (Gruber et al., 1957; Stoelting, 1957; Wyant, Dobkin and Aasheim, 1957). It was dear from these reports that methohexitone was approximately three times more potent than thiopentone. As early as 1958 Redish and others recognized its potentialities in dental anaesthesia and its use in this country for dentistry was firt reported by Drummond-Jackson and by Green and Jolly in 1960. The latter authors commented at that time that "Methohexitone is considered to have great promise in dental anaesthesia provided that it is used solely as an induction agent, and in the myH dosage described". Since then its value has been questioned, though this may have arisen because of its use in situations which have demanded from it properties which it does not possess. Before discussing the application of methohexitone to dental practice it is important to appreciate its properties.