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Plaque inhibitory effect of a 0.05% cetyl-pyridinium chloride mouth-rinse in a 4-day non-brushing model.

OBJECTIVES
Results from clinical studies evaluating the efficacy of the adjunctive use of cetyl-pyridinium chloride (CPC) containing oral hygiene products have shown wide variability, probably due to differences in formulations. The objective of this study was to determine the inhibitory plaque effect of a 0.05% CPC mouth rinse in de novo plaque formation in a 4-day non-brushing experimental model.


MATERIALS AND METHODS
The study was designed as a short-term double-blind randomized cross-over experimental model aimed to compare three products: a negative control (similar to the test product, without active ingredients), a positive control (with 0.12% chlorhexidine and CPC) and the test product (with 0.05% CPC) in terms of plaque index, gingival inflammation and microbiological variables.


RESULTS
Plaque levels after 4 days were 2.88 for the positive control, 3.86 for the negative control and 3.60 for the test. Differences among groups on day 4 were statistically significant (P < 0.001). Gingival index showed comparable values at baseline (P = 0.745), and significant increases were observed, with the exception of the positive control. Total colony forming units showed comparable values at baseline (P = 0.125) and significant increases were observed only in the negative control.


CONCLUSIONS
The tested 0.05% CPC mouth-rinse is capable of inhibiting plaque formation.