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New Frontiers in Tumor Marker Studies: From Biobanking to Collaboration in Translational Research

authors summarize practical and logistic guidelines to be applied in the construction and management of a CCB, including i) the CBB should use an internationally agreed uniform cytology terminology; ii) it is necessary that the CBB be integrated in a national or regional screening registry, and be linked to other registries (histology, cancer, vaccination); iii) legal and ethical principles concerning personal integrity and data safety must be respected strictly; iv) biobank-based studies require approval of ethical review boards. In the present issue, Nanni and colleagues discuss other aspects compromising the quality of biospecimens, such as the absence of preanalytical standardization in sample cohorts from different biobanks and even among samples within the same biobank, which may lead to incomparable results (3). In this scenario, the authors propose to collect detailed data concerning the entire life cycle of stored samples by means of radio-frequency identification (RFID) technology. In this article, the processing chain of blood samples focusing on the technological assessment of RFID tags is described in detail and critically evaluated. In recent years, RFID technology has improved the efficiency of the handling of manufactured goods and materials. Also in a clinical context, RFID enables identification from a distance, and unlike earlier bar-code technology, does not require a line of sight to the tag. In their article, Nanni and colleagues introduce the principles of RFID and discuss its primary applications and its importance in promoting best practices in biobanking (3). Moreover, they discuss that RFID makes possible to classify sample features with a sharper resolution – allowing future utilization of stored material – and to study the life cycle of the specimen, with possible feedback on the procedures. Finally, the authors underline the challenges that organizations will face in applying this technology to the clinic. Another point to emphasize among the aspects pointed out by the CBC committees is that initiatives aimed at educating researchers and at stimulating collaboration in the area of translational research are dearly needed. In fact, research is becoming increasingly collaborative, and those researchers who are able to develop good studies and use their results New frontiers in tumor marker studies: from biobanking to collaboration in translational research