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Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity

The study investigates the effect of aqueous extract of fenugreek seeds (Trigonella foenum graecum) on lipid peroxidation and antioxidant status in experimental ethanol toxicity in rats. The ability of the seed extract to prevent iron‐induced lipid peroxidation in vitro was also investigated. Ethanol feeding for 60 days resulted in signiﬁcant increases in the activities of serum aspartate transaminase, alanine transaminase and alkaline phosphatase. The levels of serum lipid hydroperoxides and thiobarbituric acid reactive substances in liver and brain were also signiﬁcantly elevated. Signiﬁcantly lower activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione S‐transferase and glutathione reductase were observed in liver and brain accompanied by depletion in glutathione, ascorbic acid and α‐tocopherol concentrations. Activity of Ca2+ ATPase in brain was signiﬁcantly lowered.