{'fraction_non_alphanumeric': 0.03373231773667029, 'fraction_numerical': 0.014145810663764961, 'mean_word_length': 5.764705882352941, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Defective natural killer cell activity and deficient production of interferon‐γ in children with acute lymphoblastic leukemia

Natural killer (NK) cell activity, OK‐432‐augmented‐NK cell activity, concentrations of interferon‐γ (IFN‐γ) in the culture supernatants of lymphocytes stimulated with OK‐432, and subsets of NK cells and memory T cells were analyzed in 42 children with acute lymphoblastic leukemia (ALL) receiving maintenance chemotherapy. Natural killer and augmented‐NK cell activities, and concentrations of IFN‐γ in the supernatants of cultured lymphocytes, were significantly lower in the patients with ALL than in age‐matched control children. Among the NK cell subsets, proportions of CD57+ cells in the patients with ALL were significantly higher than in the controls, and proportions of a memory T cell subset (CD4+ CD29+ T cells) in the patients were also significantly higher than in the controls.