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827 THE ASSOCIATION BETWEEN FASING LIPID LEVELS AND THE RISK OF INCIDENT VASCULAR, AND ALL-CAUSE MORTALITY: THE TAIPEI ELDERLY HEALTH EXAMINATION COHORT STUDY

Objective: To evaluate the association between fasting lipid levels and vascular cause-specific and all-cause mortality in a prospective cohort study. Methods:From 2001 to 2008, 115329 Taipei City elderly (aged over 65) citizens received free Physical Health Examination (PHE) at hospitals in Taipei. The PHE included medical history, physical examination and routine blood, urine and stool laboratory evaluation. Fasting lipid measures included total cholesterol (TC), triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C). The cause of death was retrieved from the National Registry of Mortality. We used hazard ratio (HR) from Cox proportional hazard model with repeat measures to assess mortality risk for Lipid levels, while controlling for potential confounding factors (sex, age, pulse, disease history, BMI and velocity of weight change). Results: A total of 7367 deaths occurred between 2003-2008. During an average 4.7-year follow-up, 1729 subjects had vascular-related deaths (946 cardiovascular disease, 636 cerebrovascular disease, and 147 hypertensive disease), while only. All three lipids measures were significantly associated with an decreased risk of all-cause mortality, while only TC and HDL-C were associated with an decreased HR of vascular-related deaths. Among cause-specific mortality, HDL-C were significantly associated with an lower risk of hypertensive mortality (HR = 0.57, 95% CI:0.37–0.88), cerebrovascular disease (HR = 0.60, 95% CI:0.47–0.76) and cardiovascular disease (HR = 0.68; 95% CI:0.56–0.83). However, TC was not associated with hypertensive mortality (HR = 1.31; 85% CI:0.68–1.98). Conclusion: In the Taipei Elderly Health Examination Cohort Study, TG was weekly associated with vascular mortality. The association between high LDL-C and low mortality risk (vascular-specific and all-cause) was nonetheless strong and consistent.