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Craniofacial development: making faces

Craniofacial development has traditionally been a field of research in which many divergent views are expressed and novel theories put forward to explain observed normal and abnormal phenomena. Decades of investigation have shown that craniofacial development is an intricate and complex series of events that require inductive and directive cell and molecular interactions to control the initiation, movement and differentiation of various embryonic cell populations across a spatial and temporal time continuum that results in the correct outgrowth, patterning and tissue integration required to make a face. This special issue of the Journal of Anatomy contains review articles written by speakers from the ‘Craniofacial Development: Making Faces’ symposium held as part of the Winter Meeting of the Anatomical Society at Oxford in January 2005. The volume covers wide-ranging aspects of craniofacial development from the evolution of the head, tissue patterning and morphogenesis to human syndromes and malformations. The thoughtful and insightful reviews illustrate many foci of current research in this area and highlight the challenges that lie ahead in fully understanding the mechanisms underlying the processes required to generate the vertebrate head.