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Tau, neural function, and episodic memory in the medial temporal lobe

The human medial temporal lobe (MTL) is heavily connected with neocortical regions in the posterior‐medial and the anterior‐temporal system. In order to achieve successful memory functioning, those systems have to interact with each other as well as with the hippocampus. At the same time, subregions in the MTL are affected by neurofibrillary tangle (NFT) pathology in aging and Alzheimer's disease (AD) which is strongly associated with memory impairment.