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MELANOTROPIC DRUGS AND RETINAL FUNCTIONS

The acute effects of chlorpromazine, promethazine and rifampicin on the a‐, b‐ and c‐waves of the conventional electroretinogram (ERG) were studied in sheep. Iv administration of chlorpromazine and promethazine resulted in a b‐wave amplitude decrease and an initial c‐wave amplitude decrease, followed by cyclic amplitude changes resembling damped oscillations. Iv injections of rifampicin, however, resulted in cyclic changes of the c‐wave amplitude without initial concomitant b‐wave changes. The results of the present study indicate that rifampicin has a selective influence on the pigment epithelial cells, while chlorpromazine and promethazine seem to have more generalized retinal effects on both the neuro‐retina and the pigment epithelial cells.