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Intracranial Pressure Increases During Hindlimb Suspension

One of the responses following exposure to the microgravity spaceflight environment is a pronounced cephalic fluid shift. Recent evidence documents ocular changes in astronauts following long‐duration missions including optic disc edema, globe flattening, choroidal folds and hyperopic shifts. These changes are hypothesized to result from this cephalic fluid shift, as these ocular effects are similar to those seen in terrestrial Idiopathic Intracranial Hypertension (IIH) and are associated with increased intraocular pressure (IOP). Long duration missions are currently being undertaken on the International Space Station (ISS) and planning for manned missions to Mars has begun. This project aims to simulate long‐term microgravity cephalic fluid shift using a well‐established terrestrial rat model to provide a means for study of the mechanisms underlying ocular changes seen in spaceflight.