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A developmental comparison of steroid-induced and male-induced ovulation in young mice.

evaluated the ovulatory efficacy of a range of doses of injected estrogen and documented the importance of progesterone in steroid-induced ovulation in young mice. In the primary experiments, immature females were male-exposed, injected with an estradiol-progesterone sequence, or left undisturbed, all treatments lasting for three days and being initiated at all one gram ranges in body weight during the relevant stages of development. As adjudged by uterine growth, the ability to release estrogen in response to a male matures early in the life of a female mouse. The capacity to ovulate in response to three days of male exposure, however, develops much later and simultaneously with the establishment of