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Computerised automatic warnings about drug interactions are now available

Editor–Duncan Raistrick and colleagues' report about the interaction between methadone and rifampicin is yet another reminder that adverse interactions are not always easy to identify and prevent.1 This particular interaction was first identified over 20 years ago2 yet seems to have been overlooked by whoever first prescribed rifampicin to the patient reported on by the authors.

It is beyond anybody's capacity to remember all the important interactions, and inevitably oversights like this one happen. In this case the patient came to no harm, …