{'fraction_non_alphanumeric': 0.042281879194630875, 'fraction_numerical': 0.013422818791946308, 'mean_word_length': 5.482608695652174, 'pattern_counts': {'":': 0, '<': 3, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Chronic ethanol feeding and microvillus membrane glycosylation in normal and protein-malnourished rat intestine.

Ethanol feeding to rats for 40 days enhanced (p < 0.001) the activities of alkaline phosphatase, sucrase, gamma-glutamyltransferase (GTP), and p-nitrophenyl (PNP)-beta-D-galactosidase (p < 0.05) with no change in leucine amino peptidase (LAP) and PNP-beta-D-glucosidase activities in intestine compared with control rats. The activities of alkaline phosphatase, sucrase, and GTP were diminished (p < 0.01) in ethanol-fed malnourished rats. There was no change in LAP activity, but the levels of glucosidase and galactosidase were elevated under these conditions. Brush-border sialic acid, fucose, hexose, and hexosamine contents were elevated in ethanol-fed protein-deficient animals. Ethanol administration to normally fed rats elevated the membrane sialic acid and hexose contents, reduced fucose content, and had no effect on brush-border hexosamine content compared with the control group. These results are in agreement with data on lectin binding to brush borders under these conditions. Alcohol ingestion reduced the incorporation of [14C]-glucosamine into brush borders in rats maintained on an 18% protein diet but augmented the incorporation of [14C]-glucosamine and [14C]-mannose in protein-malnourished membranes. These observations suggest that nutrition status influences the sensitivity of microvillus membrane glycosylation to ethanol feeding in rat intestine.