{'fraction_non_alphanumeric': 0.036290322580645164, 'fraction_numerical': 0.011088709677419355, 'mean_word_length': 6.41044776119403, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Long‐term Depression in the Hippocampal CA1 Region is Associated with Equal Changes in AMPA and NMDA Receptor‐mediated Synaptic Potentials

In the CA1 hippocampal region low‐frequency (1‐2 Hz) afferent activation leads to a long‐term depression of excitatory synaptic potentials that is induced by calcium influx through postsynaptic N‐methyl‐d‐aspartate receptor channels. In the present experiments using 2‐ to 3‐week‐old rats, long‐term depressions of field excitatory postsynaptic potentials mediated by amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) and by N‐methyl‐d‐aspartate receptor channels were examined in parallel, using a perfusion solution containing low concentrations of an AMPA receptor antagonist and of magnesium (0.1 mM). These experiments revealed that long‐term depression was associated with equal relative changes in the two components of the field potential, compatible with a presynaptic location of the expression mechanism for the long‐term depression.