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Acceleration of casein induced amyloidosis in mice by immunosuppressive agents.

The effect of various immunosuppressive agents on the experimental mice amyloidosis has been examined. The mice were pretreated with 21 injections casein, on day 1, 3 and 5 after this treatment 12 immunosuppressive agents were applied to 12 groups of mice in dosis corresponding to LD10. All drugs applied accelerated the amyloidosis, even they differ in metabolic blocking potencies. The results seem to indicate that any interference with the immune apparatus of the mice favours the development of amyloidosis.