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Engineered IL‐10: A matter of affinity

Interleukin (IL-)10 plays an important immunoregulatory role due to its ability to elicit anti-inflammatory responses on innate and adaptive immune cells.1 Discovered in 1989 by Fiorentino et al., IL-10 was described as a Th2-cell-derived cytokine that could suppress cytokine synthesis in Th1 cells.2 Later on, it was demonstrated that IL-10 could be produced by other cells including regulatory T and B cells,3 macrophages, dendritic cells (DCs) and innate lymphoid cells (ILCs).4 IL-10 has been studied in different fields, including immune tolerance to allergens and to infectious agents, organ transplantation, and oncology.5.