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Comparative Plasma Levels of Vitamin D in Women with or without Uterine Fibriods in Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria

Background: Fibroids are commonest benign tumour of the uterus in reproductive age women. Surgical treatment has been the mainstay of treatment for symptomatic fibroids. Recently, hypovitamin D has been associated with fibroid. The aim of the study was to compare the level of vitamin D in women with fibroids and women without fibroids. Aim: To determine and compare plasma levels of Vitamin D in women with uterine fibroids and those without uterine fibroids Method: An institution based case control study comprising of 274 women. It compared the serum levels of 25 hydroxy vitamin D in 137 women with uterine fibroids and 137 women without uterine fibroids as controls. Result: The level of vitamin D in the women with and without uterine fibroids were {13.5ng /ml, (IQR 3.8 – 22.1)} and {52.1 ng/ml, (IQR 30.6 – 75.0)} (P = < 0.001) respectively. Conclusion: The plasma level of 25-Hydoxy vitamin D was significantly lower in women with uterine fibroids and higher in women without fibroids. Subsequently, prompt detection of vitamin D deficiency by screening with effective treatment may reduce the incidence of fibroids and its sequelae in these group of women.