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[The becoming of function and metabolism of subcutaneous insulin-dependent adipocytes on stages of phylogenesis. The etiologic factor and pathogenesis of obesity as a pandemic].

The visceral fatty cells of omentum and insulin-depended subcutaneous adipocytes implement simultaneously three reactions: a) biological reaction of exotrophy - absorption of fatty acids in the form of non-polar triglycerides; b) active depositing of fatty acids in non-polar triglycerides and c) releasing of fatty acids in blood plasma only in the form of unesterified fatty acids. The single pool of intercellular medium is a little bit of the third world ocean that: a) was privatized by every entity in the moment of going out to dry land and in which b) as millions years in ocean before, continue to live cells. At the level of paracrin cenosis of cells regulation is worked out related to: a) a single pool of intercellular medium; b) local pools of medium; c) size (number of cells) and organs. Under obesity, increasing of number of insulin-depended subcutaneous adipocytes results in: a) increasing of volume of distal part of arterial channel; b) slowing down of bloodstream, biological reaction metabolism-micro-circulation is disturbing, O2 clearance decreases, excretion of catabolites is deranged; c) multiplicity of blood turnover in capillaries is decreased; d) implementation of biological functions of homeostasis, trophology, biological function of endoecology and adaptation are disordered. The compensation in vivo of biological reaction of metabolism-micro-circulation at obesity includes: a) decreasing of number of insulin-depended subcutaneous adipocytes; b) decreasing of volume of distal part of arterial channel and c) decreasing of volume of circulating blood. The decreasing of volume of blood in arterioles of muscular type occurs by means of activation of secretion of early in phylogenesis brain natriuretic peptide, then ventricle and atrium natriuretic peptide. In biological function of homeostasis, natriuretic peptides are synergists with action of humoral mediator of aldosterone. Jointly, they support constancy of parameters of single pool on intercellular medium: aldosterone is called to exclude pool's decreasing and natriuretic peptides to exclude its increasing.