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The quest for histology driven neoadjuvant chemotherapy in soft-tissue sarcoma: End of road or just the beginning?

427 The role of chemotherapy in high-risk nonmetastatic soft-tissue sarcoma (STS) is modest as per the existing evidence. By and large, the chemotherapy regimen used in adjuvant and neoadjuvant setting had been a combination of anthracycline and ifosfamide. Increasingly simulating the approval of trabectedin and eribulin in specific histologies of STS, there is an ardent desire by sarcoma medical oncologists to sieve out the apt chemotherapy regimens for specific subtypes of sarcoma in adjuvant/neoadjuvant setting.[1,2]