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A novel hydrocolloid film based on pectin, starch and Gunnera tinctoria and Ugni molinae plant extracts for wound dressing applications.

BACKGROUND
The biodegradable and biocompatible nature of pectin-based films is of particular interest in wound dressing applications, due to its non-toxicity, pH-sensitivity and gelling activity. An approach to improve the mechanical performance, release profile of bioactive compounds and dissolution in contact with water of pectin-based films is mixing with other biopolymers.


OBJECTIVE
To prepare hydrocolloid films based on crosslinked pectin and starch blend with bioactive extracts from leaves of G. tinctoria and U. molinae with controlled release of bioactive compounds and healing property.


METHOD
The hydrocolloid films were characterized by FTIR, SEM, and TGA-FTIR techniques and their tensile properties, water uptake, and polyphenolic release profile in aqueous media were evaluated. The dermal anti-inflammatory activity of the hydrocolloid films was assessed by the mouse ear inflammation test. The wound healing property of the loaded hydrocolloid films was explored in a rat model and in a clinical trial (sacrum pressure ulcer).


RESULTS
The films showed an adequate water-uptake capacity between 100-160%. The release of active compounds from the hydrocolloid films followed the Korsmeyer-Peppas equation. The mechanical properties of hydrocolloid films were not affected by the plant extracts within the concentration range used. The incorporation of the bioactive extracts in the polysaccharide films inhibited the topical edematous response by about 50%. Topical application of the loaded hydrocolloid film on the pressure ulcer is completely closed after 17 days without showing any adverse reaction.


CONCLUSION
A novel hydrocolloid matrix was produced from crosslinked starch-pectin, which exhibited suitable chemical-physical properties to be used as a carrier of plant extracts.