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Chrysobalanus icaco L. Anthocyanins Reduced Cell Proliferation and Inflammation in HT‐29 Colon Cancer Cells

Chrysobalanus icaco L. (CI) is an anthocyanin‐rich fruit found in tropical areas around the globe that has not yet been widely investigated. The objective of this study was to assess the anti‐inflammatory and anti‐proliferative activities of polyphenols extracted from CI in HT‐29 colon cancer cells (1.0 to 20.0 mg/L GAE). The anthocyanins profile of the extract was determined by HPLC‐MS and identified predominantly acylated glucosides of delphinidin, cyanidin, petunidin, peonidin and malvidin. Cell proliferation was suppressed at 20.0 mg/L. This was accompanied by an increase in intracellular ROS production as well as decreased gene expression of TNF‐α, IL‐1β, IL‐6 and NF‐κB at 20.0 mg/L. These results suggest C. icaco anthocyanins posses chemopreventive activities by reducing the cell proliferation and inflammation in human colon cancer cells and these preliminary findings should be followed up with in vivo and mechanistic studies. Financial support: CNPq.