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Associations Between Markers of Inflammation and Hemoglobin Concentration: Implications for Diagnosis of Anemia in Women of Reproductive Age

Inflammation reduces Hb concentrations, increasing anemia estimates, but the magnitude of this effect in different populations is unknown. We explored associations between inflammation (defined as C‐reactive protein (CRP) > 5mg/L and/or α1–acid glycoprotein (AGP) >1g/L), Hb concentrations, and their interpretation in defining anemia (Hb <120 g/L) in women of reproductive age (WRA). Data from 10,483 non‐pregnant WRA who participated in national surveys in 8 countries were analyzed using complex survey techniques by the Biomarkers Reflecting Inflammation and Nutrition Determinants of Anemia (BRINDA) project.