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Immunological Alterations in Psoriasis

"The immunologic literature on psoriasis is remarkable not only for its length but also for its negativity."*^ This statement made by William Epstein in 1971 no longer seems to hold true. In recent years, many studies on psoriasis have been published showing the presence of certain immunologic abnormalities in patients with this condition: serum immunoglobulin changes, the presence of circulating antibodies, certain T cell dysfunctions, the presence of in vivo bound anti-stratum corneum antibodies in lesional epidermis, an increased frequency of certain histocompatibility antigens and very recently, a clear-cut enhancement of several phagocyte functions such as chemotaxis, phagocytosis and bactericidal activity. The following is an attempt to review in a comprehensive and systematic way the immunologic changes known today to exist in psoriasis.