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Hyperbranched poly(L-lysine) containing additional amino acids or their oligomers between branching points: Synthesis and structure

A new method of preparing hyperbranched poly(L-lysine) was developed. This method includes the catalytic removal of a N e -carbobenzyloxy blocking group from N e -carbobenzyloxy-L-lysine-N-carboxyanhydride by hydrogen in the presence of an activated palladium. Under similar conditions, hyperbranched poly(amino acids) containing residues of glutamic acid or alanine and their oligomers, along with residues of lysine or their oligomers, between the branching points, lysine residues, or outside of them were prepared from N e -carbobenzyloxy-L-lysine-N-carboxyanhydride and N-carboxyanhydrides of γ-tert-butyl-L-glutamate or L-alanine. The macromolecular structure and conformation of hyperbranched poly(L-lysines) were examined by static and dynamic light scattering, sedimentation-diffusion analysis, and circular dichroism. It was demonstrated that the polymers have a compact symmetric shape that differs appreciably from the rodlike structure of a linear poly(L-lysine).