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Effects of insulin‐like growth factor‐I on growth hormone and prolactin secretion and cell proliferation of human somatotrophinomas and prolactinomas in vitro

OBJECTIVE IGF‐I inhibits GH secretion from normal and some tumorous pituitary tissue, and has been shown to be mitogenic for gonadotrophinoma cells in vitro. It is not known whether IGF‐l affects somatotrophinoma cellular proliferation or the secretion of other hormones, such as PRL and α‐subunit, which are often co‐secreted by these tumours. We have therefore examined the effects of IGF‐l on proliferation and hormonal secretion of human somatotrophinomas and prolactinomas in vitro.