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[Effect of phenethyl isothiocyanate given at different duration of gestation on the outcome of pregnancy in rats].

OBJECTIVE
To investigate the effect of phenethyl isothiocyanate (PEITC) on fetal development and embryotoxicity in rats.


METHODS
Acute oral toxicity was conducted by Horn method. PEITC suspended in Tween-80 water was administered orally once a day to pregnant rats in the gestation day 0 -6 (pre-implantation) and 7 - 16 (post-implantation) at the doses of 15, 60 and 120 mg/kg, respectively. On the gestation day 16 or 21, the number of live fetuses, reabsorbed fetuses and implanted sites were counted. The placental weights, fetal weights and organ weights were also recorded.


RESULTS
The LD50 of PEITC for female rats was 1.47 g/kg. The maternial body weight gain and the number of implanted and live fetuses were decreased with the increase of PEITC dosage given during pre-implantation period. There was also a dose-dependent effect of PEITC given during post-implantation period on fetal weight/growth and placental weight. No toxicity on the organ weight of pregnant rats was observed.


CONCLUSION
Phenethyl isothiocyanate given at different duration of gestation exhibited some embryo-toxicity on pregnant rats, and the no observable adverse effect level was 15 mg/kg.