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Both collagen and elastin matrices are remodeled in the failing ovine atria – a role for elastin‐degrading enzymes in atrial structural remodeling

Left atrial (LA) remodeling is a feature of the full spectrum of heart failure (HF) and LA structural remodeling (fibrosis) will contribute to diminished ventricular contractile function and risk of atrial fibrillation. Whilst the fibrotic potential of the LA in HF has been documented, the mechanism by which this occurs, and the role of other matrix proteins is less well understood.