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AB0570 CLINICAL STUDY OF THE DISEASE ACTIVITY AND IMMUNE SCREENING OF PRIMARY SJOGREN’S SYNDROME

Objectives: To evaluate the change features of peripheral blood lymphocyte subsets and disease activity in patients with primary Sjogren’s syndrome before and after treatment. Methods: A total of 30 patients with primary Sjogren’s syndrome in the Department of Rheumatology from the Second Hospital of Shanxi Medical University from January 2016 to December 2018 were enrolled. According to the treatment time of patients, they were divided into baseline group, 0-3 months group, 3-6 months group, 6-12 months group, and the absolute counts of T, B, NK, Th1, Th2, Th17 and regulatory T cells(Tregs) in peripheral blood of patients before and during the treatment were measured by flow cytometry. The ratio of various cells to Tregs was calculated as well.The primary Sjogren’s syndrome disease activity was assessed according to the Sjögren’s syndrome disease activity index (ESSDAI) score and compared with 30 healthy people. Results: The Tregs counts in the disease group were significantly lower than those in the healthy control group (p<0.05), and the ratio of proinflammatory lymphocytes to Tregs (Th17/Treg) was higher(p<0.05).Tregs counts in peripheral blood of patients with primary Sjogren’s syndrome has increased significantly after 3-month treatment,at the same time, the inflammatory index ESR was significantly lower (p<0.05), the ESSDAI score was significantly lower (p<0.05), and the high remission rate was maintained. However there was no statistically significant increase in Treg cell growth before treatment at 3-6 months and 6-12 months, (p>0.05).Figure 1 The Tregs counts in the disease group were significantly lower than those in the healthy control group (p<0.05), and the ratio of proinflammatory lymphocytes to Tregs (Th17/Treg) was higher(p<0.05).Tregs counts in peripheral blood of patients with primary Sjogren’s syndrome has increased significantly after 3-month treatment.Figure 2 the inflammatory index ESR was significantly lower (p<0.05), the ESSDAI score was significantly lower (p<0.05), and the high remission rate was maintained. Conclusion: The imbalance between pro-inflammatory lymphocytes and Tregs caused by the significant decrease of Tregs may be the cause of primary Sjogren’s disease activity. We propose to promote the growth of Tregs and maintain the balance between pro-inflammatory lymphocytes and Tregs,which provides a new idea for disease relief of primary Sjogren’s syndrome. Disclosure of Interests: None declared