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STUDIES OF IN VITRO STEROID METABOLISM BY TESTIS TISSUE FROM ‘COMPLETE’ AND ‘INCOMPLETE’ FORMS OF TESTICULAR FEMINIZATION

The in vitro steroid metabolism of testicular tissue from seven cases of testicular feminization was studied. Using radioactive steroid substrates of both C21 and C19 configurations, kinetic studies of these tissues showed that the major pathway of testosterone production was via the Δ5 pathway, i.e. pregnenolone → 17α‐hydroxy‐pregneolone → dehydroepiandrosterone → androstenedione and androstenediol → testosterone, with the accumulation of dehydroepiandrosterone and androstenediol. This accumulation of dehydroepiandrosterone and androstenediol does not occur in similar incubations of normal human testis tissue.