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Acute Changes in Serum Estradiol Concentrations Do Not Elicit Changes in Serum Osteocalcin Concentrations

Circulating osteocalcin (OC) concentrations reflect the rate of osteoid synthesis by osteoblasts in both physiologic and pathophysiologic conditions.’ It has previously been reported that acute changes in circulating sex steroid levels can alter serum OC concentrations reflecting acute changes in bone metabolism.2 The purpose of this study was to determine whether short-term changes in circulating serum estradiol (E2) produced alterations in circulating OC levels and further to determine whether a dose-response relationship existed.