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Control of Inflammatory Damage by Anti-Lfa-1: Increase Success of Myoblast Transplantation

• Abstract — Myoblast transplantation is a potential treatment for Duchenne Muscular Dystrophy. This article confirms by experiments in mice that one problem that has limited the success of clinical trials of this procedure is a rapid (within 3 days) inflammatory reaction which kills most of the injected myoblasts. The death of the trans­ planted myoblasts can be prevented by treating the host with a mAb against LFA-1. This led to a 27-fold increase in the number of muscle fibers expressing a reporter gene present in the donor myoblasts when the host is also ad­ equately immunosuppressed with FK506. Therefore, both the nonspecific inflammatory reaction and the specific im­ mune response should be adequately controlled following myoblast transplantation. © 1997 Elsevier Science Inc.