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THE FOLDING AND BINDING PATHWAY OF THE TRANSCRIPTION FACTOR CREB TO CBP

A central tenet of genomics is that sequence determines structure, and structure determines function. Even though this is true for most proteins, in the last years an increasing number of proteins have been found that are natively unfolded. For many of these proteins, this intrinsic disorder appears to be required for their function. Many transcription factors have been experimentally observed to be unstructured in solution. Transcription factors are central components of intracellular regulatory networks that control the expression of genes involved in a variety of biological processes, ranging from cell proliferation and differentiation to migration, and their aberrant activity can result in tumorigenesis. The cAMP‐response element binding protein (CREB) is one of the best characterized transcription factors in terms of structure and function.