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Comprehensive management reduces incidence and mortality of acute chest syndrome in patients with sickle cell disease

multicenter European study, we were not able to identify reliable predictors of SVT recurrence, in our patient cohort. On the other hand, both studies were in agreement in terms of their failure to demonstrate the therapeutic value of systemic anticoagulation, and the non-trivial rate of event recurrence. Accordingly, it is reasonable to query the value of alternative forms of systemic anticoagulation, such as the use of direct-acting oral anticoagulants, despite the challenge of securing optimal anti-thrombotic effect against the ever present risk of bleeding. In our opinion, primary prevention through avoidance of precipitating factors and aggressive management of high risk patients remains the best treatment approach.