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Arousal Promoting Effects of Basal Forebrain are Mediated through Prefrontal Cortex in Rat

We recently showed that cholinergic stimulation of prefrontal cortex (PFC), via local carbachol delivery, increased local acetylcholine (ACh) levels and restored wakefulness in sevoflurane‐anesthetized rats.[1] PFC receives cholinergic projections from basal forebrain (BF), and activation of cholinergic BF neurons has been shown to promote behavioral arousal.[2] Increase in prefrontal ACh during carbachol‐induced wake state reflects BF activation, but it is not known if BF acts via PFC to promote behavioral arousal. The objective of the current study is to test the hypothesis that PFC gates the arousal promoting effects of BF.