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[The effect of new quinolone antimicrobial agents and macrolide antibiotics on the clearance of theophylline].

Many drugs have been found to increase or decrease the clearance of theophylline. Some of new quinolone antimicrobial agents (ciprofloxacin, enoxacin, pefloxacin and tosufloxacin) and macrolide antibiotics (erythromycin, troleandomycin, roxithromycin and clarithromycin), are potent inhibitors of the metabolism of theophylline. Concomitant administration of these drugs may, thus, prolong the half-life of theophylline, elevate serum theophylline concentrations, and increase the risk of theophylline-related adverse events. Therefore, these data indicate that careful clinical and pharmacokinetic monitoring of patients receiving both theophylline and some of antimicrobial agents should be carried out.