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ASSOCIATION OF FORCED EXPIRATORY VOLUME WITH DISEASE DURATION AND SPUTUM NEUTROPHILS IN CHRONIC ASTHMA

Little SA, MacLeod KJ, Chalmers GW, Love JG, McSharry C, Thomson NC. Am J Med. 2002;112:446–452 

Some patients with chronic asthma develop irreversible airflow obstruction. The aim was to assess whether reported duration of asthma and induced sputum cell counts were associated with pulmonary function in patients with asthma who did not smoke.

Maximal forced expiratory volume in 1 second (FEV1) was determined after a steroid trial (oral prednisolone, 30 …