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[Study on the association between HPV16/18 and expression of p53 protein in laryngeal papillomas].

OBJECTIVE
To understand the relationship between the expression of p53 protein and HPV16/18 infection in laryngeal papillomas.


METHOD
Using PCR and immunohistochemistry techniques examined the paraffin embedded tissues of 35 cases of laryngeal papillomas.


RESULT
Showed that HPV16/18-DNA were found in 24 cases of laryngeal papillomas (68.8%); overexpression of p53 protein were detected in 19 cases (54.3%); both of HPV16/18-DNA and overexpression of p53 protein were demonstrated in 12 cases of laryngeal papillomas (34.3%).


CONCLUSION
This study suggests that HPV16/18 infection and p53 gene mutation are associated with pathogenesis of laryngeal papillomas. The relation between HPV infection and p53 mutation in tissues of laryngeal papillomas remains to be clarified.