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Response to "Drug Diffusion to the Apex of the Human Cochlea?".

In summary, the primary conclusion in the abstract that ‘‘Bisphosphonate introduced via the oval window in the human cochlea can be delivered up to the apical cochlear turn’’ may be true for the dead, partially disintegrated ear but cannot be assumed to occur the live state. The authors should have made clear that for numerous reasons, the distribution reported here will be very different from that in a live ear, to which this or any other drug is locally applied.