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[Pathological study of ER and PR in osteosarcoma].

OBJECTIVE
To determine the relationship between estrogen receptor (ER), progesterone receptor (PR) and pathological characteristics of osteosarcoma.


METHOD
ER and PR were detected by streptavidin/peroxidase (SP) method immunohistochemically using the paraffin embedded tissues from 65 cases of osteosarcoma. The patients were typed and graded pathologically according to Liu Zijun's classification.


RESULT
The positive rates of ER and PR were 40% (26/65), 32.3% (21/65) respectively. The positive particles were distributed in cytoplasm and nucleus. The positive rates of ER and PR in osteosarcoma with higher cell differentiation grade were higher than those in the tumor with lower one. The differences were statistically significant (P < 0.05). There were no relations to the pathological type.


CONCLUSION
ER and PR exist in osteosarcoma and their positive rates are related to the cell differentiation of osteosarcoma.