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Melatonin inhibits growth of diethylstilbestrol‐induced prolactin‐secreting pituitary tumor in vitro: possible involvement of nuclear RZR/ROR receptors

Melatonin exerts a marked antiproliferative action in numerous experimentally‐induced tumors in vivo as well as in both animal and human cell lines in vitro. However, the mechanisms of oncostatic action of melatonin is not clear, and the involvement of both membrane and nuclear receptors are suggested. Therefore, the aim of this study was to investigate effects of melatonin, and both agonist (CGP 52608), and antagonist (CGP 55644) of RZR/ROR nuclear receptors on the growth of diethylstilbestrol‐induced rat prolactin‐secreting pituitary tumor cells in vitro.