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Effector‐cell blockade. II. A demonstration of the reversible masking of an immune response by blockade of antibody‐forming cells

Previously we showed that multivalent forms of antigen could specifically block the effective secretion of antibody by binding to the antibody‐forming cell (AFC). We termed this inhibition of antibody‐secretion at the level of the AFC “effector cell blockade” (ECB). The present paper shows that dinitrophenylated gelatin, (DNP‐GEL), can induce ECB in vitro. Thus, portions of a suspension of spleen cells from DNP‐immune mice were incubated for 30 min with DNP‐GEL, washed and then assayed for anti‐DNP‐plaque‐forming cells. The resultant plaques were much fewer and smaller than those in assays of control portions of the spleen cell suspension. This DNP‐GEL‐induced ECB was shown to be reversible by treatment of the DNP‐GEL‐incubated cells with the specific enzyme collagenase. The reversibility of ECB by removal of extracellular antigen was confirmed using the multivalent antigen DNP‐glucan, together with the enzyme β‐lichenase, an enzyme with no action on mammalian carbohydrates.