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Hemostasis and clotting markers and its significances in unstable angina pectoris patients complicated with diabetes mellitus

Background: Recent studies have confirmed that patients with unstable angina pectoris (UAP) complicated with diabetes mellitus(DM) have obvious per-thrombosis state. However, it is not clear that the changes of the hemostasis and clotting markers are very clear. Therefore, this paper is to determine the hemostasis and clotting markers in patients with UAP complicated with DM and those without DM and compared with the control group. Methods: Forty patients with UAP, forty patients with UAP complicated with DM, and forty healthy participants were included in the study as UAP group, complication group, and control group, respectively. Levels of platelet membrane glycoprotein(GP), Von Willebrand (vWF), plasminogen, antithrombin III(ATIII), factor VIII-related antigen(VIII: Ag), platelet membrane glycoprotein-140(GMP-140), protein C(PC), factor II activity(FIIa), tissue plasminogen activity(t-PA), PA inhibitor(PAI), D-dimer, and thromboxane B2(TXB2) were measured in all groups. Results: Compared with a control group and UAP group, there were significant changes of GP, vWF, ATIII, VIII: Ag, GMP-140, PC, FIIa, t-PA, PAI, D-dimer, and TXB2 in complication group (P<0.05, or P <0.01). Compared with control group, there were significant changes of GP, vWF, ATIII, VIII: Ag, GMP-140, PC, FIIa, t-PA, PAI, D-dimer, and TXB2in UAP group (P <0.05, or P <0.01). Conclusions: There are significant changes of hemostasis and clotting markers in patients with UAP, especially in those complicated with DM, which may be an important reason for the poor prognosis of these patients.