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A6688 The effect of salt intake on blood pressure variability in normotensive and mild hypertensive salt-sensitive Chinese Adults

Objectives: High dietary salt intake was reported to increase blood pressure, but no study has investigated the effect of high dietary salt intake on blood pressure variability (BPV) in an intervention trial. Our aim was to assess if high salt intake is related to ambulatory BPV. Methods: The study included 49 subjects (23 male, 26 female) were selected from a rural community of northern China with a mean age of 56.1 ± 10.35 years. All subjects were sequentially maintained on a relatively low-salt diet for 7 days (3.0 g/day of NaCl), a high-salt diet for 7 days (18.0 g/day of NaCl). All the patients underwent 24-h ambulatory blood pressure monitoring at baseline and on the last day of each intervention to determine BP levels, the 24-h systolic BPV and 24-h diastolic BPV. 24-h urine sodium and Potassium were measured. The correlation between BPV and 24-h urinary sodium or Potassium was investigated. Results: High-salt diet induces the increase in BP levels and its variability based on ABPM and low-salt diet may induces the decrease in SS Chinese adults but not SR. Further analyses revealed that a positive relationship between the 24-h urinary sodium excretion and nighttime systolic ARV derived from ABPM in SS Chinese adults but not SR. No significant association between 24-h potassium excretion and nighttime systoli Conclusion: Our study indicates that variations in dietary salt intake had a significant effect on ambulatory BPV in SS Chinese subjects and that Sodium restriction may have an additional therapeutic advantage to lower the risk for cardio-cerebrovascular complications by decrease BP variability.