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An Impedance Flow Cytometer Chip with Tunable Impedance Responses for High Sensitive Cellular Biomarker Detection

This paper presents a method to improve the sensitivity of an impedance flow cytometry (IFC) chip by tuning its parasitic capacitance and operating frequency. First, an equivalent impedance model of IFC chip was used to study parasitic capacitance effect, and a numerical simulation was used to predict the operating frequency shift of various electrode arrangements; Secondly, we validated our theoretical study using three types of electrode arrangements fabricated by soft lithography techniques; Thirdly, we characterized the impedance responses of our device. By using staggered electrode configuration, the parasitic capacitance was reduced by 57.7%, while the center operating frequency was increased by a factor of 4.3. Finally, we evaluated our chip’s cell classification performance with white blood cells (WBC) and tumor cells MCF-7. Based on a machine learning algorithm, the cell classification accuracy is high than 99.2%.