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Study of the Relation between ApoE ε 4 Allele and Hippocampal Atrophy in Alzheimer Disease

Objective:To investigate the relationship between ApoEe4 allele and hippocampal atrophy in patients with AD.Methods:Using MRI-based volumetry techniques and PCR-FRLP,the hippocampal volume and ApoE genotype of 34 AD patients were examined,and the differences of the hippocampal volume between the ApoE e4 positive AD group(n=17)and the ApoEe4 negative AD group(n=17)were analyzed.The relationship between a number of ApoE e4 allele and the hippocampal volume has also been evaluated.Results:The volume of ApoEe4 positive AD group was significantly less than that of the ApoEe4 negative AD group(P0.05),and there was a negative relationship between a number of ApoEe4 allele and the hippocampal volume(r s=-0.210,P=0.0024),that is to say,the more of the number of ApoEe4 allele the patient has,the less the hippocampal volume he or she will have.Conclusion:There is a relationship between ApoEe4 allele and the hippocampal atrophy in AD,and it might play a role in the pathology of AD.