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Regional perfusion of VX 2 carcinoma with cis-DDP.

High dose effect of regionally applied cis-DDP was studied using VX 2 carcinoma as a tumor model. The tumors were transplanted on both hind limbs of New-Zealand rabbits. After strict standardization of the methods, treatment with cis-DDP systemically was compared to regional treatment with cis-DDP by isolated perfusion on extremities. These results were related to untreated controls. Therapeutic effect was determined by comparing the average tumor diameters at various time points after the end treatment. Remission could be induced for a short period by systemic treatment. After isolated perfusion, remission was continuous during the observation period. There was no therapeutic benefit by a dose increase from 20 to 40 mg cis-DDP/kg limb weight.