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Reduced local immune response with continuous positive airway pressure during one-lung ventilation for oesophagectomy.

Editor’s key points † One-lung ventilation can cause local and systemic inflammatory responses. † In this study of patients undergoing oesophagectomy, cytokine concentrations in broncho-alveolar lavage fluid were lower in patients receiving CPAP to the collapsed lung. † There were no differences in systemic concentrations of inflammatory markers or clinical outcomes. † Furtherdata are required to confirm these findings and investigate any clinical benefit. Background. Transthoracic oesophagectomy requires prolonged one-lung ventilation causing systemic and local inflammatory responses. Application of continuous positive airway pressure (CPAP) to the collapsed lung potentially reduces pulmonary damage, hypoxia, and consequent inflammation. This randomized controlled trial studied the influence of CPAP applied to the collapsed right lung during thoracoscopic oesophagectomy on local and systemic inflammatory response.