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Reproductive function in the genetically obese "fatty" rat.

This study characterized some of the abnormalities in reproductive function of the Fatty (fa/fa) strain of genetically obese rats. “Fatty” females were demonstrated to have delayed vaginal opening, prolonged estrous cycles, decreased uterine weight and absence of deciduomata formation during reserpine-induced pseudopregnancy. These findings are consistent with a decreased estrogen secretion or impaired estrogen effect. However, serum LH and FSH, instead of being elevated as expected in hypoestrogenized animals, were identical to lean controls, thus suggesting a second defect in hypothalamic-pituitary threshold to feedback inhibition of gonadotropins. The latter postulated defect would appear to be partial as serum LH and FSH increased normally in response to castration. Moreover, ovarian hypertrophy occurred in response to unilateral ovariectomy. (Endocrinology 93: 1251, 1973)