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Immunohistochemical Analysis Of Breast Cancer Subtypes And Their Correlation With Ki 67 Index.

BACKGROUND
Breast cancer is the second most common cancer in females including Pakistan. Nowadays immunohistochemistry has revolutionized management of breast cancer. In this study, we determined the frequency of various subtypes of breast cancer on the basis of immunohistochemical staining and their correlation with ki 67 index.


METHODS
Fifty consecutive diagnosed breast cancers cases received during the period February 2014 to February 2016, at Ayub Medical College, Pathology Department were included in this cross-sectional study. Immunohistochemistry for Oestrogen receptor (ER), Progesterone receptor (PgR), Her2neu and ki 67 index were applied and the results were recorded.


RESULTS
Out of 50 cases, 34 (68%) were positive for ER and PgR, 6 (12%) were positive for her 2 neu while 6 (12%) were triple positive and 4 (8%) were triple negative.


CONCLUSIONS
Low risk Luminal A was the most frequently encountered breast cancer category.