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Inbreeding coefficients and degree of consanguineous marriages in Spain: A review

The contribution of consanguineous marriages corresponding to uncle–niece or aunt–nephew (C12), first cousin (C22), first cousin once removed (C23), and second cousin (C33) to the inbreeding coefficient (α) was analyzed from a sample of Spanish areas and periods. Multiple regressions were performed taking as independent variables the different degrees of consanguinity previously selected (C12, C22, C23, and C33) and as dependent variable the inbreeding coefficient (α). According to the results obtained for any degree and period, rural frequencies always surpass urban. However, the pattern is similar in both areas. In the period where consanguinity was more elevated (1890–1929) the C22/C33 ratio increased. Its variation is not due to C22 and C33 changes in the same way. In rural areas, this ratio surpasses the expected value by a factor of 2–3, but in urban areas it was 7–10 times larger, in some cases due to migration. While in rural Spain the C33 frequency was ∼1.5 times C22, in cities C22 was 1.5 times C33. The best fit among the various types of consanguineous matings and α involves a lineal relationship. Regardless of the number of variables contributing significantly to α, C22 matings are always present. Moreover, their standardized (β) coefficients are the highest. The above indicates that this consanguineous relationship conditions the inbreeding coefficient the most. In the period of greater consanguinity, close relationships, uncle–niece C12, and first cousin once removed (C23) make a significant contribution to α. In rural Spain second cousins (C33) always significantly determined α; however, in cities the inbreeding variation was mainly due to C12 and C23. Am. J. Hum. Biol. 15:709–716, 2003. © 2003 Wiley‐Liss, Inc.