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Use of posaconazole delayed‐release tablets for treatment of invasive aspergillosis

A 65‐year‐old man developed Aspergillus brain abscesses following surgical resection of a sinus aspergilloma. He was treated with voriconazole for 1 year but infection recurred. We elected to treat with posaconazole delayed‐release tablets, currently only indicated as antifungal prophylaxis in high‐risk patients. A maintenance dose of 300 mg Q24 h resulted in a therapeutic serum concentration and appears safe and clinically effective thus far. This is the first report of successful use of posaconazole tablets for treatment of invasive aspergillosis.