{'fraction_non_alphanumeric': 0.02548131370328426, 'fraction_numerical': 0.026047565118912798, 'mean_word_length': 5.156794425087108, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
T‐Cell Receptor Gene Expression by Human γδ T‐Cell Clones from Peripheral Blood and Reproductive Tissues in Relation to Non‐MHC‐Restricted Cytotoxic Function

T‐cell receptor γ and δ gene expression was determined using V‐region‐specific monoclonal antibodies in conjunction with Southern blot analysis in panels of γδ T‐cell clones from human peripheral blood (n = 77) and reproductive tissue (n = 9). Whereas 53 out of 77 (69%) clones from peripheral blood expressed Vγ9 and Vδ2Jl, only 2 out of 9 (22%) from reproductive tissues expressed Vδ2J1. Two out of eight decidual clones expressed both Vγ9 and VδJ1, while this configuration was rare in clones from peripheral blood. The majority of clones from the peripheral blood of one donor expressed Vγ8 and Vδ3J1. Clones were identified which expressed Vδ1J1 in the disulphlde‐linked Cγ1 form of the receptor and which expressed a gene other than Vδ1 in the non‐disulphide‐linked Cγ2 form, indicating incomplete concordance between expression of Vδ1 and Cγ2. Vδ3 could be expressed in the disulphide‐linked or non‐disulphide‐linked form of the receptor. At least 5 out of 77 peripheral clones were expressing Vδ genes other than Vδ1. Vδ2. or Vδ3 in conjunction with Cγ1 or Cγ2. There was a strong but incomplete correlation between high non‐NHC‐restricted cytotoxic function and Cγ1 expression. Clones from the same donor expressing both Vγ9JPCγ1 and Vδ2J1 showed either high or negligible cytotoxicity. and cytotoxic clones expressing Cγ2 were found. Thus no complete correlation between cytotoxic function and expression of a particular form of the yδ heterodimer was identified. The results also suggest that yδ T cells from reproductive tissues are less likely to express Vδ2J1 than those from peripheral blood.