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The effectivity of single and combined dose of oseltamivir therapy on length of stay of COVID-19 patients in Mataram General Hospital, Indonesia

Background: Oseltamivir is an antivirus for the corona virus which is currently used as part of the therapy regiment for COVID-19 patients. This is because the definite antivirus of choice for COVID-19 is yet to be found. The combined administration of oseltamivir and antibiotics compared with oseltamivir alone is known to shorten the hospitalization length of patients with severe respiratory infections in the ICU. However, there is no solid data explaining the effectiveness of oseltamivir, both alone or as part of a combination therapy, in the prevention and treatment of COVID-19 patients. The success of treating confirmed COVID-19 patients who are hospitalized can be seen from the length of patient hospitalization. This study aimed compare the length of hospitalization between patients with confirmed COVID-19 cases receiving oseltamivir alone or in combination with antibiotics.Methods: This study was conducted using an analytical observational design with a cross sectional approach. The samples were 238 people hospitalized at the Mataram General Hospital who were sampled using a total sampling technique according to the inclusion and exclusion criteria.Results: Amongst the 238 confirmed COVID-19 patients hospitalized at the Mataram General Hospital, 52.5 % received oseltamivir alone, while 47.5% received a combination of oseltamivir and azithromycin. Analysis showed that there was a significant difference in the length of hospitalization between both groups (p<0.001).Conclusion: The hospitalization period of patients given oseltamivir-azithromycin combination therapy was relatively shorter than that of patients given oseltamivir alone.