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[Expressions of p21 and CD44v in human lung cancer and their significance.].

BACKGROUND
To investigate the clinical role of p21 and CD44v in primary lung cancer and their relationship with each other.


METHODS
p21 and CD44v expression in 29 frozen lung cancer and 10 corresponding non-cancer tissues were measured by flow cytometry (FCM) .


RESULTS
In lung cancer , the expression rates of p21 and CD44v were 75. 9 % and 51. 7 % respectively. The two proteins showed much higher FI values and positive rates in lung cancer than those in non-cancer tissues ( P < 0. 01) . p21 alteration was independent from tumor size ,lymph node metastasis , TNM stage , differentiated grade and histological type. CD44v expression in stage II+III(83. 3 %) was much higher than that in stage I(29. 4 %) ( P < 0. 01) . As compared with lung cancer without lymph node metastasis (33. 3 %) , primary lung cancer with lymph node metastasis showed significantly higher expression rate of CD44v (81. 8 %) ( P < 0. 05) . Coexpression of p21 and CD44v had a distinct statistic significance ( P < 0. 01) .


CONCLUSIONS
Abnormality of p21 and CD44v may be involved in the carcinogenesis and development of lung neoplasms in coordination. Immunopositivity of CD44v may suggest a potential of high risk for lymph node metastasis in lung cancer.