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Locally Advanced Breast Cancer, Its Management with Neoadjuvant Chemotherapy and Its Response in Southern Part of Odisha

BACKGROUND Locally Advanced Breast Cancer (LABC) is a subset of breast cancers characterized by advanced breast tumours in the absence of distant metastasis. The need to identify LABC as a separate group of breast cancers arose in view of the high associated rate of locoregional and systemic failure. Management includes multimodality treatment which is complex. LABC is the most common mode of presentation in the region of study i.e. the southern part of Odisha. Aim is to study the multimodal treatment and its response as provided in this institution. This prospective study Postgraduate General M.K.C.G. Medical Hospital, Berhampur, Orissa, from July 2017 to June 2019 including 6 months of follow up period. 49 cases of locally advanced breast cancer were included in the study. Multimodal treatment including surgery and chemotherapy was offered. chemotherapy, modified radical mastectomy, adjuvant chemotherapy achieved superior locoregional control and delayed systemic dissemination. Maximum clinical response was seen in paclitaxel receivers i.e. complete response in 22 % and partial response in 77 % of cases with 0 no response rates. After 6 months of follow up of multimodal treatment of LABC, the overall survival rate is maximum in stage IIIA with 95.8 %, followed by 83.3 % in stage IIIB and 42.8 % in stage IIIC. Surgery and chemotherapy are more effective in locally advanced breast cancer than surgery alone and paclitaxel as chemotherapy displays high level of antitumour activity.