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Emerging modifiable risk factors for cardiovascular disease in women: obesity, physical activity, and sedentary behavior.

Cardiovascular disease (CVD) remains the leading cause of death among women in the United States. In 2008, more than 400,000 women died of CVD.1 The increased risk of CVD from established modifiable risk factors—tobacco use, hypertension, diabetes mellitus, and hypercholesterolemia—is well documented.2 More recently, nonestablished behavioral and lifestyle risk factors—like obesity, physical inactivity, and sedentary behavior—have been studied. Understanding the crucial role that weight and daily activity play in CVD risk can greatly influence the counseling advice and recommendations that clinicians give their patients.