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Interferon Levels and Resistance to Viral Infection Associated with Selected Interferon Inducers

Summary Comparative studies of protection of mice against infection with MM virus and levels of interferon induced by graded amounts of Escherichia coli endotoxin, statolon, maleic acid-divinyl ether copolymer, and polyinosinic-polycytidylic acid complex have been carried out. In every instance, both protection and interferon response were dose-dependent, but interferon titers did not correlate with protection. The degree of protection could not be correlated to any specified amount of interferon. Possible explanation of these results would include: (i) protective potency of interferon may differ with the type of inducer, (ii) different interferons are utilized for protection in different ways, or (iii) the protective effect of inducers used may be unrelated to interferon.