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The ultrastructure and immunohistochemistry of the septum pellucidum in a case of thalamic low grade astrocytoma with review of literature

This article presents the results of light and electron microscopic (EM) findings of the septum pellucidum (Sp) in a case of thalamic low grade astrocytoma. Furthermore, it presents immunohistochemical staining of the Sp which has not been previously reported in the literature. The tissue specimen was obtained from a 34 year-old male patient, who had undergone subtotal tumor excision operation by the neurosurgery department. The intact part of the Sp was taken for routine light, transmission (TEM), scanning electron microscopic (SEM) and immunohistochemical examinations. In light microscopy and TEM examination the myelinated axons were small and medium sized. There was no grey matter in the examined area. In SEM examination, there were holes between the ependymal cells that showed transition zones between the inside of cavity and outside of it. In the immunohistochemical examination of the cryosections of the Sp, the ependymal lining cells were reactive with mAb B-F45. Significance and function of this antigen on ependymal cells remains to be clarified. The connection, relationships and function of the Sp is important in the human body. This detailed case study gives information for further research.