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Effect of Actinomycin D and Estradiol on the Response to LH-Releasing Hormone in Neonatally Androgenized Female Rats 1

Summary The effect of estradiol, actinomycin D, or both, on pituitary response to LH-RH was studied in 6-month-old female rats which had been injected with testosterone propionate on the 2nd day of life. Estradiol significantly augmented the pituitary response to LH-RH. Actinomycin D did not significantly modify basal serum LH levels and pituitary response to LH-RH but did significantly inhibit the augmenting effect of estradiol on such a response. The authors wish to express their gratitude to Dr. G. D. Niswender, Dr. L. E. Reichert, and N.I.A.M.D.D., Rat Pituitary Program, Bethesda, MD, for the gifts of reagents used in the radioimmunoassays and to Dr. V. Yohai for assistance in the statistical calculations of the data.