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FACILE SPECTROPHOTOMETRIC DETERMINATION OF NIMODIPINE AND NITRAZEPAM IN PHARMACEUTICAL PREPARATIONS

A simple, accurate and sensitive visible spectrophotometric method for the determination of nimodipine (NMD) and nitrazepam (NTZ) is described. The method is based on the diazotization of reduced drugs with nitrous acid followed by coupling with resorcinol to form colored azo/dye in an alkaline medium. The resulting colored azo/dye exhibits maximum absorption peak at 480 nm for both NTZ and NMD. Beer's law was obeyed over the concentration ranges 0.5/10 and 1.0/40.0 5g/mL for NTZ and NMD, respectively. The calculated molar absorptivities are 1.84 × 10 4 and 0.67 × 10 4 L mol /1 cm /1 for NTZ and NMD, respectively. All the variables such as effect of acid, alkali and reaction time were studied in order to optimize the reaction conditions. No interference from the excipients added to tablets was found. Statistical analysis of the results using Student's t/test for accuracy and F/test for precision revealed no significant difference between the proposed method and the literature method. The accuracy and validity of the methods were further established by recovery studies through the standard addition technique.