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Tissue Engineered Cartilage Patches for Laryngotracheal Reconstruction

Galway, Ireland Tissue Engineered Cartilage Patches for Laryngotracheal Reconstruction James E. Dennis, David Gilpin, Mark Weidenbecher, Corresponding Author: James.Dennis@case.edu Case Western Reserve University, Cleveland, OH, USA and University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH USA Introduction Currently, the treatment for tracheal stenosis in infants is to use costal cartilage for laryngotracheal reconstruction (LTR) to widen the tracheal lumen. However, there is not sufficient costal cartilage for infants less than 6 months in age, plus there is the potential for pneumothorax when harvesting costal cartilage. To address this problem, auricular chondrocytes were used to engineer a cartilage patch for LTR in a rabbit model.