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Sickledex test for hemoglobin S. A critique.

The Sickledex test has been proposed as "specific" for hemoglobin S in the absence of a disclosure of the principle and reagents. Its convenience and simplicity has already assured widespread usage. But serious errors will be made unless the chemistry of the test is understood and coupled with the insights of modern molecular hematology. Evidence indicates that the Sickledex test consists of potassium phosphate, sodium dithionite, and saponin. When this test is used with insight, much diagnostically valuable information can be obtained.