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BAYESIAN APPROACH TO THE DETERMINATION OF THE KINETIC PARAMETERS OF DNA HAIRPINS UNDER TENSION

In this paper we propose a Bayesian scheme for the determination of the unfolding and refolding kinetic rates of DNA hairpins under tension. This method is based on the hypothesis that the unfolding-refolding dynamics is well described by a Markov Chain. The results from the Bayesian method are contrasted to widely used techniques and good agreement is found. This work can be seen as a validation of the standard techniques from a statistical point of view.