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[Defect in the organification of iodide in patients with Hashimoto's thyroiditis (author's transl)].

Abnormalities in iodide organification were studied in patients with Hashimoto's thyroiditis. 1) A thiocyanate discharge test was performed in 18 patients with proven Hashimoto's thyroiditis. The per cent discharge of the test was significantly higher in groups with lower level of T4 (<5.5 big/d1), RSU (<25.5%) and BMR (<+2.5%), and higher levels of TSH (>10.0b1U/m1). The per cent thiocyanate discharge was increased in parallel with the degree of hypothyroidism. 2) The content of thyroidal iodine, protein and thyroglobulin was significantly decreased in 5 euthyroid as well as in the remaining hypothyroid patients with Hashimoto's thyroiditis compared with normal tissue (p<0.05, p<0.01 respectively). 3) In 5 euthyroid patients with Hashimoto's thyroiditis, thyroidal peroxidase (TPO) activity (8.17 ± 1.3 U, mean ± SE) was significantly less than in normal tissue (p<0.01). In 5 hypothyroid patients, TPO activity (27.64 ± 13.8 U) was almost the same as in normal tissue (33.7 ± 5.4). A positive correlation was obtained between TPO activity and serum TSH in ten patients with Hashimoto's thyroiditis (r=0.85, p<0.01). 4) In iodination of thyroglobulin in vitro, the per cent of radioiodine bound to the thyroglobulin was normal in two and increased in one euthyroid patient with Hashimoto's thyroiditis. But it was decreased in two and normal in one hypothyroid patient with Hashimoto's thyroiditis. Hypothyroidism was present despite normal TPO activity and positive discharge test was frequently observed in hypothyroidism with Hashimoto's thyroiditis. Since the degree of