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AB0574 The Relationship Between Anti-C Reactive Protein (CRP) Antibody and Disease Activity in Patients with Systemic Lupus Erythematosus

Background Systemic erythematosus lupus (SLE) is an autoimmune disease with multi-organ involvement and diverse autoantibodies are associated with SLE [1]. Recently, many reports have suggested that anti-C reactive protein (CRP) antibody is more prevalent in patients with SLE, and the level of anti-CRP antibody increases when the disease flares up [2]. Objectives This study was performed to investigate the relationship between anti-CRP antibody and the disease activity markers in Korean patients with SLE. Methods 29 patients with SLE and 30 healthy people were enrolled between April 2014 and November 2014. The presence of anti-CRP antibody was analyzed by enzyme-linked immunosorbent assay (ELISA). Data on clinical variables and disease activity markers, such as complement, anti-dsDNA antibody, and systemic lupus erythematosus disease activity index (SLEDAI) were recorded. Results The level of serum anti-CRP antibody in SLE patients was significantly higher than that of healthy controls (p=0.035). However, anti-CRP antibody levels were not positively correlated with the complement levels, the SLEDAI score, and anti-dsDNA antibody levels. And also there was no significant difference in the level of anti-CRP antibody between the patient group with lupus nephritis and the patient group without lupus nephritis. Conclusions This study shows the presence of serum anti-CRP antibody in Korean SLE patients. But there was no significant relationship between anti-CRP antibody and disease activity, lupus nephritis. These findings are not consistent with previous study that anti-CRP antibody is a useful marker to evaluate the disease activity. References Shere Y, et al. Semin Arthritis Rheum 2004;34:501-37. Sjöwall C, et al. Arthritis Res Ther 2004;6:R87-R94. Disclosure of Interest None declared