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Abstract 2347: Incidence and mortality rate of liver and intrahepatic bile duct cancer in the United States, 2000-2016

Introduction: Liver and intrahepatic bile duct cancer is highly deadly. Incidence and mortality rates of Liver and intrahepatic bile duct cancer have increased significantly from 2000-2016 in the United States. The purpose of this study is to investigate the incidence and mortality rates of this cancer according to sex and race. Methods: We used the Surveillance, Epidemiology, and End Results (SEER) 18 data to calculate age-adjusted incidence and mortality rates from 2000-2016. Annual Percent Change (APC) was obtained for incidence and mortality rates by sex and race. Results: Between 2000 and 2016, the incidence rate increased significantly for both male and female from 8.9 to 13.0 and 3.3 to 4.7 per 100,000 persons, respectively. Additionally, the highest incidence rates have been reported among Hispanic, non-Hispanic American Indian/Alaska Native and non-Hispanic Asian or pacific Islander with 13.5, 14.6 and 11.6 per 100,000 persons, respectively. Overall mortality rate has increased specifically among male from 5.1 to 10.9 per 100,000 persons during the same period. Hispanic, non-Hispanic American Indian/Alaska Native and non-Hispanic Asian or Pacific Islander still have the highest mortality rate compared to other race/ethnicity with 11.3, 12.9 and 9.4 per 100,000 persons), respectively. From 2015 to 2016, incidence and mortality rates have decreased among all races and gender. Conclusions: Hispanic, non-Hispanic American-Indian/Alaska native and non-Hispanic Asian or pacific Islander are at greater risk of developing and dying from this cancer. Additionally, males are more likely to acquire and die from this cancer. Prevention programs should focus on these populations in order to reduce the burden of this cancer. Further studies are necessary to examine the alarming increase in overall incidence and mortality rates of this cancer. Citation Format: Michael Rutalira Koko, Glodi Mutamba. Incidence and mortality rate of liver and intrahepatic bile duct cancer in the United States, 2000-2016 [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 2347.