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Failure of terfenadine in relieving the pruritus of atopic dermatitis

We report the results of a double‐blind, placebo‐controlled, cross‐over study of terfenadine 120 mg twice daily for pruritus in atopic dermatitis. Twenty‐eight subjects with chronic atopic dermatitis received both terfenadine 120 mg b.d. and placebo each for a period of 1 week. Response was recorded by the subjects using visual analogue scales for severity of pruritus twice daily for the last 4 days of each treatment phase. There was no benefit from terfenadine.