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Autoimmune disease in the dog

IT was early in the 1900s that a German microbiologist, Paul Ehrlich, introduced the concept of 'horror autotoxicus' to express the underlying biological principle that an animal generally does not respond to the chemical groupings in its own body. Ehrlich speculated that if it did, the body's immune system would injure its own tissues, causing autoimmune disease. It is now known that autoimmunity is a primary cause or a secondary contributor in many well recognised diseases. Autoimmune disease is characterised by the presence in the blood and, or, tissues, of autoantibodies or autoreactive cells. Autoantibodies are capable of reacting against self components. Autoreactive cells are immunocytes capable of also reacting against self. For a disease to be truly autoimmune, these autoantibodies and autoreactive cells must be involved in the pathogenesis.