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Emerging role of notch 1 signaling in brown adipogenesis.

In recent years, activation or harvesting of classical brown adipose tissue (cBAT) or the browning of white adipose tissue (WAT), or beige fat, have attracted immense attention as potential new therapeutic strategies. This is particularly the case for the browning of the WAT approach in part because a significant portion of the active BAT detected in adult humans is beige fat by gene profiling [2]. Drug discovery along this line of investigation is on-going but not without challenge in human translation [1 & ].