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[Determination of intrapulmonary shunt in acute lung failure and during therapy by means of extracorporeal oxygenation (author's transl)].

The reasons for the especial importance of acute lung failure within the framework of intensive medicine are elaborated. In most cases acute lung failure can be successfully treated by timely ventilation and support for the heart-function. If conventional therapy fails, extracorporeal long-term oxygenation by means of a membrane oxygenator can be a successful technique, provided that a very critical indication is available. The magnitude of the intrapulmonary right-left shunt S is an important parameter for the assessment of the extent of acute lung failure and its prognosis, and also in the establishment of the indication for the use of extracorporeal oxygenation and the therapeutic process. The derivation of simple extended shunt equations for any form of extracorporeal oxygenation is possible on the basis of measurements of blood-flow and oxygen transport. This represents an important contribution to the mathematical description of a therapeutic technique.