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Bisatellited extra small metacentric chromosome in newborns

Among 5,049 consecutive liveborn children in a Danish maternity hospital, three had an extra small bisatellited metacentric chromosome, apparently an isochromosome of the short arms of a D or G group chromosome. In two of the probands' families, the deviating chromosome was inherited through three generations. One proband was a mosaic; her grandmother, mother and one sister had the karyotype 46, XX,9qh+; one of her brothers had the karyotype 46, XY,9qh+, and he had one daughter with the karyotype 46, XX,9qh+ and another daughter who was 45, X.