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Clinical analysis of gouty patients with normouricaemia at diagnosis

Gouty attacks usually occur in patients with hyperuricaemia, but patients with gout who have normouricaemia are believed to be in the minority.1,2 This is a common conception about gout because monosodium urate crystals are formed at blood concentrations of uric acid over 420 μmol/l at a body temperature of 37°C.3 Recently, two studies showed that the incidence of gouty attacks in normouricaemia was as high as 39–43%,4,5 which is much higher than our traditional view.1–3 However, few data on normouricaemia in gout have been reported so far.6–8 The prevalence of patients with gout who have normouricaemia at diagnosis has not yet been determined, and even their clinical characteristics and laboratory findings have not been reported.

We designed this study to determine the …