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Methodological needs and pharmacological research with adult dental patients.

The final statement of the Consensus Development Conference on Anesthesia and Sedation in the Dental Office concluded that the "available evidence suggests that the use of sedative and anesthetic drugs in the dental office by appropriately trained professionals has a remarkable record of safety."1 This statement was made despite the panel's conclusion that "Reliable national estimates of mortality or morbidity associated with the use of general anesthesia and sedation in the dental office are not avail-able for the United States" and that "Data concerning morbidity are extremely limited and do not permit the calculation of rates." This dichotomy between the conclusion that anesthesia and sedation in the dental office are "remarkably" safe and the lack of reliable data led the panel to propose that "There is a critical need for a comprehensive approach to research in dental anesthesiology." The purpose, in part, of this workshop is to specifically identify these critical areas of need, to identify the appropriate methods for conducting well-controlled clinical trials of drugs used for anesthesia and sedation, and, possibly, to identify drugs or combinations which require further evidence to support their use in rational therapeutics, The evaluation of drugs used for anxiety relief in dental outpatients falls into a scientific and regulatory void. The paucity of published articles on the use of drugs for dental outpatient sedation and anesthesia indicates that little scientific activity exists in this area.