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Feasibility and stability of metaraminol in pre‐filled syringes

Metaraminol 10 mg/mL injection is often diluted with sodium chloride 0.9% and pre‐drawn into syringes by anaesthetists for use in the management of intraoperative hypotensive crisis. The 10 mg/mL ampoule presentation poses a significant safety hazard since the entire content needs to be drawn into a syringe and then diluted so that 0.5 mg doses may be administered. There have been incidents where 10 mg rather than the intended 0.5 mg have been administered to the patient. Additionally the pre‐drawn metaraminol is discarded at the end of the case if not used, which results in significant wastage. A pre‐filled syringe presentation of metaraminol will improve patient safety and reduce wastage.