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Prediction of Serum Vancomycin Concentrations using One‐, Two‐ and Three‐compartment Models with Implemented Population Pharmacokinetic Parameters and with the Bayesian Method

Although previous studies have shown that vancomycin has a complicated pharmacokinetic profile requiring description using a two‐ or, better, three‐compartment model, until recently predictions of serum vancomycin concentrations have been mainly based on one‐ or two‐compartment models using computer software packages. In this study, we have predicted serum vancomycin concentrations in 59 patients using one‐, two‐ and three‐compartment models with implemented population pharmacokinetic parameters in the Abbott PKS program and by use of the Bayesian method.