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Metastatic Lung Adenocarcinoma to the Iris Mimicking Cogan-Reese Syndrome

PurposeCase report of metastatic lung cancer to the iris mimicking Cogan-Reese syndrome. MethodsA 61-year-old female with a history of non-small cell lung cancer presented with unilateral elevated intraocular pressure (IOP) and multiple hyperpigmented iris nodules associated with an anterior iris membrane. The patient's IOP could not be controlled medically, so she underwent trabeculectomy with simultaneous iris biopsy. ResultsHistopathology revealed proliferation of glandular epithelium on the iris surface consistent with metastatic lung adenocarcinoma. ConclusionsIris metastases have varied presentations, and one must consider metastatic disease in any patient with a history of cancer presenting with iris lesions. The formation of an iris membrane and nodules by metastatic adenocarcinoma to the iris may mimic Cogan-Reese syndrome.