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A0821 Cardiac biomarkers and lipid profile levels in patients with acute myocardial infarction and antecedent arterial hypertension

Objectives: To determine the peculiarities of cardiac biomarkers serum levels and lipid profile changes in patients with acute myocardial infarction (AMI) and antecedent hypertension (AH). Methods: 35 hypertensive patients (31 men, 14 women; mean age 64.28 ± 8.93 years; duration of hypertension 9.8 + 3.7 years) and 31 normotensive patients with their first Q-AMI were examined. Groups were comparable in age and gender. The levels of troponin, creatine kinase-MB (CK-MB), myoglobin, C-reactive protein (CRP) and ESR were determined in blood of all patients. Blood lipid test was done. Results: AH was associated with a significantly increased baseline risk profile: higher body mass index, higher incidence of metabolic syndrome and diabetes, dyslipidemia, p < 0.05 for all). Patients with AH had significantly higher levels of total cholesterol (+16.7%, p = 0.012), triglycerides (+27.3%, p = 0.006), low-density lipoproteins (+14.5%, p = 0.025), and lower levels of high-density lipoproteins (−16.2%, p = 0.013). Patients of both groups demonstrated increase of cardiac biomarkers. However, patients with Q-AMI and AH had significantly higher level of troponin I (+22.7%, 31.4 ± 3.02 ng/ml, p = 0.007) and CK-MB (+17.1%, 254.4 ± 19.3 units/L, p = 0.003) than patients without AH. The myoglobin levels differed insignificantly in studied groups (103.8 ± 14.6 vs 94.7 ± 11.8, p ≥ 0.05). Patients of the main group also demonstrated higher levels of inflammation markers: CRP (+28.5%, p = 0.016) and ESR (+16.2%, p = 0.036). Conclusion: Patients with Q-AMI against the background of AH are prone to more significant myocardial injury, lipid metabolism derangements, and inflammatory response than normotensive Q-AMI patients, and therefore require more accurate approach to evaluation and treatment.