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Nodular melanoma arising in a patient treated with anti‐tumor necrosis factor alpha antagonists

Figure 1 The neoplasm is asymmetric (a, ·20), with a junctional component (b, ·200) and involvement of the hair follicle (c, ·200). There are dermal mitoses (d, ·400) and confluence of the dermal nests e, ·200). The tumor cell populations are different: some large with abundant cytoplasm while others are small and spindle-shaped with little cytoplasm. Histological examination reveals a brisk tumor infiltrating lymphocytes (f, ·200)