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Image cytometry and chemoprevention in cervical cancer

Of the approximately 60 million Pap smears performed in the United States in 1995, about 8% or 5 million will show cytology that is “not negative” (ASCUS, AGCUS, LSIL, HSIL, etc.). Possibly 15% or about 0.7 million of these cases will have positive follow‐up by repeated Pap smears, colposcopy or biopsy. More than 4 million will be false‐positive smears based on the reference standard of biopsy or repeated smears. If no treatment or medical intervention was offered to the 0.7 million cytologically and histologically positive cases, perhaps 20,000 (3%) would develop into invasive cancer. Of the original 5 million cytologically “not negative” cases, fewer than 0.5% have the potential to develop into invasive cancer.