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Progress in Synthesis and Bioactivity Evaluation of Pyrazoloquinazolines



This paper reviews the research progress of pyrazoloquinazolines which
widely used in the field of medicine and pesticide in recent years. Five types of
pyrazoloquinazolines are introduced: pyrazolo [4,3-h]quinazolines, pyrazolo[1,5-c]quinazolines,
pyrazolo[4,3-f]quinazolines, pyrazolo[1,5-a] quinazolines , pyrazolo[1,5-b]quinazolines, and their
new progress in the synthesis methods and treatment of diseases.



The derivatives of pyrazoloquinazolines exhibit a wide range of pharmacological
properties such as antibacterial, anticancer, antioxidants, anti-inflammatory, anti-diabetic, antiviral
activities. Consequently, their syntheses have attracted significant interest. Various methodologies
have been developed for the synthesis and functionalization of these class of compounds.



In the present article, the relevant and recent advances in the field will be briefly
covered.
