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Interferon modifies EEG and EEG-like activity recorded from sensory, motor, and limbic system structures in freely behaving rats.

The finding of major interest in the present experiment is that interferon injection in normal animals modifies the EEG and EEG-like activity in all the structures examined independently (unsynchronized in time). The initial effects were observed in the hypothalamus followed by limbic, somatosensory, and motor structures, respectively. The effects observed were mainly increases in the amplitude of the dominant frequency and irregular spiking. The irregular change in the amplitude remained during the six hours of the recording sessions. Complete recovery was observed twenty-four hours after drug injection.