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Intravenous ondansetron versus lidocaine as pretreatment drugs to prevent pain on propofol injection

Background Propofol is one of the most popular intravenous anesthetics used for induction and maintenance of anesthesia and sedation in and outside of the operating room. Its role is valuable especially for day-case surgeries, and with laryngeal mask airways. Pain on propofol injection still remains a common anesthetic problem. This study aimed at comparing the effectiveness of pretreatment with ondansetron, a common antiemetic agent, with lidocaine, the commonest drug/method for prevention of this pain. Materials and methods This study included 100 women, American Society of Anaesthesiologists physical status classification I–II, scheduled for gynecological surgery under general anesthesia and randomly categorized into two equal groups. Group I (group O) received 4-mg (2 ml) ondansetron, whereas group II (group L) received 40-mg (2 ml) lidocaine 2%, accompanied by manual venous occlusion for 1 min, and then 25% of the total induction dose of propofol (2.5 mg/kg) was initially injected through the same cannula, and patients were asked for pain rating using a four-point verbal rating scale. Results The incidence of pain was higher in group L than group O, with 17 (34%) patients versus 13 (26%) patients, respectively; however, both groups were still comparable (P>0.05). Three (6%) patients in group O versus four (8%) patients in group L complained of severe pain (P>0.05). Three (6%) patients in each group had moderate pain (P>0.05). Seven (14%) patients in group O versus 10 (20%) patients in group L experienced mild pain (P>0.05). Conclusion Both ondansetron and lidocaine were similarly effective pretreatment drugs for prevention of propofol-induced pain.