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The development of endolymphatic hydrops following cmv inoculation of the endolymphatic sac

The effect of inoculation of cytomegalovirus (CMV) into the endolymphatic sac was examined in CMV‐seronegative and seropositive animals. Seronegative animals developed hearing loss, infection in the epithelial cells of the endolymphatic sac and perisaccular connective tissue, and endolymphatic hydrops. Control animals inoculated with inactivated CMV showed no hearing loss, viral infection, or endolymphatic hydrops.