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Intragraft expression of transforming growth factor β1 gene in isolated glomeruli from human renal transplants

Experimental evidence suggests that transforming growth factor (TGF) β1 is a fibrogenic cytokine. The histopathological changes of chronic renal allograft nephropathy are dominated by fibrotic changes and TGF‐β may have an important aetiological role. This study investigated the relationship between intragraft TGF‐β gene expression and extracellular matrix protein deposition in human renal allografts.