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Activation of hormone‐sensitive adenylate cyclase by forskolin

An overview of the organization of adenylte cyclase systems and various sites for regulation is presented. These components are discussed with respect to the activation of adenylate cyclase by forskolin. Evidence for direct activation of adenylate cyclase as well as potentiation of hormone‐activated adenylate cyclase by forskolin is reviewed, as these data relate to the possible site(s) of action of forskolin. Studies of the action of forskolin in different systems and interaction studies with different regulators of adenylate cyclase have yielded valuable information about the regulation of adenylate cyclase and the relationship of its various components. A better understanding of these relationships may reveal new therapeutic potential for forskolin.