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Serum IgE Level in Systemic Lupus Erythematosus Associated Nephropathy

The present study aimed to measure the total IgE levels in Iraqi SLE patients with renal involvement. The study involved a total of 136 SLE patients with renal manifestations (76 females and 60 males) who attended one of Baghdad's private hospitals and had haemodialysis from January 2017 to May 2018. In addition, a total of 36 apparently healthy age and gender matched individuals were also included in the study as a control group. Measurement of C4 showed no significant difference between patients (57.30 ± 1.393 mg/dl) when compared to the control (55.17 ± 3.111 mg/dl). A highly significant increase was shown in the level of total IgE in patients as compared to control (43.04 ±28.75 and 16.11 ± 5.075 IU/ml respectively). Interestingly, analysis of total IgE levels according to the number of haemodialysis that the patients needed revealed that SLE patients who needed haemodialysis for three time had the highest level of total IgE (105.0±62.86 IU/ml) at the beginning of SLE flare, followed by the patients who had haemodialysis for two times (62.64 ±18.26), while the patients who needed haemodialysis for one time only (31.26 ±23.49 IU/ml) had the lowest level of total IgE.