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[Annexins as a new thrombotic factors].

This review retraces the current state of knowledge on Annexin A2 and A5 functions causing thrombophilia. Thrombophilia is multifactorial inherited hypercoagulable state, promoted by multiple gen-gen and gen-environmental factors. Abnormalities of placenta in intervillous spacies and horion vessels are discussed as venous thrombosis. The cause of adverse pregnancy outcome is still unknown, etiological up to 50% of cases. Understanding of function of sequence variations in potencial risk factors annexins A2 and A5 could precise estimation of individual risk and should guide the adequate prophylaxis among pregnant women.