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THU0335 Microvascular Findings in Patients with Systemic Lupus Erythematosus - Assessed by Fundus Photography and Fluorescent Angiography

Background Although a series of trials support systemic lupus erythematosus (SLE) is associated with increased atherosclerosis and cardiovascular events, the link between microvascular structural change and the disease activity of SLE is not defined. Objectives We measured retinal microvasculature change by fundus photography and fluorescent angiography (FAG) and investigated the association between retinal vasculature and clinical parameters of SLE. Methods Fifty SLE patients and fifty healthy controls were included. Morphometric and quantitative features of the capillary image including retinal vascular sign and vessel diameters were measured with fundus photography and FAG. Information concerning SLE duration, cumulative dose of steroids and/or immunosuppressive drug intake were recorded, and autoantibodies were checked. SLE activity was assessed by SLE disease activity index (SLEDAI). Results The mean Central retinal arteriolar equivalent (CRAE) was 89.7 ± 14.5 µm in SLE patients, 123.8 ± 19.9 µm in control, showing narrower arteriole in SLE patients, and were significantly narrower than that of control (p < 0.001). The mean central retinal venular equivalents (CRVE) was 127.7 ± 14.8 µm, and but it reached no statistical significance (144.1 ± 23.1 µm, p = 0.226). Retinopathy was found in 26% of SLE patients. SLE patients with retinopathy were older than those without it, but reached no statistical significance. Disease duration, antidsDNA, and complement levels had no effect on the presence of retinopathy. SLE patients with retinopathy had a tendency to have higher cumulative steroid doses, hsCRP and IgG aCL levels than those without retinopathy. With multiple regression analysis, hsCRP and IgG aCL were identified as contributing factor to the decreased CRAE, whereas no contributing factor was found to CRVE Conclusions retinopathy and retinal arteriolar narrowing were more common in SLE patients, and retinal arteriolar diameter had significant correlation with hsCRP and IgG aCL levels. Retinal imaging is a comparative method for the assessment of microvascular findings of SLE patients. Disclosure of Interest None Declared