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Vitamin A and biochemical development. I. Effect of postnatal excess vitamin-A administration on lipogenesis in various organs of the rat.

The effect of the administration of an excessive dose of vitamin A (1,000 IU) to rat pups on the 4th, 6th, 8th and 10th days of age was studied on the contents of saponifiable (total fatty acids) and non-saponifiable (cholesterol) lipids. Lipogenesis and cholesterogenesis was studied with the help of sodium-1-14C-acetate incorporation. The heart, liver and lung showed impaired lipogenesis while in the brain only cholesterogenesis was affected.