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QuantiFERON-TB Gold Plus Assay Specificity in Children and Adolescents With Suspected Tuberculosis—A Multicenter Cross-sectional Study in Spain

Supplemental Digital Content is available in the text. In this cross-sectional study of 284 children and adolescents with clinically or radiologically suspected tuberculosis in a low-endemic country, the QuantiFERON-TB Gold Plus assay specificity, sensitivity, positive predictive value and negative predictive value were 91.5%, 87.3%, 86.4%, and 91.2%, respectively. The specificity was higher than that observed in tuberculin skin tests performed simultaneously, but similar to previous-generation interferon-gamma release assays.