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A Mentalization-Informed Staging Approach to Clinical High Risk for Psychosis

The practice of diagnosis is fundamentally designed to orient treatment. In the case of early diagnosis for schizophrenia spectrum disorders (SSP) risk, the empirical base for such a practice is still young, and many clinical questions arise in the everyday clinical application of risk algorithms and ensuing therapeutic options. One of the key questions that we will focus on is the following: in cases of SSP where symptoms are successfully treated, why does residual social functioning impairment remain the most serious obstacle to remission and reinsertion in society? We will present the evidence suggesting that the roots of residual social functioning impairment may, in many cases, come from thwarted or arrested development in the specialization of social cognition during adolescence and early adulthood. We will review the evidence suggesting that both during the premorbid phase and clinical high-risk phase, attenuated psychotic symptoms may impede the maturation of key social cognitive processes, particularly the suite of reflective thinking processes coming under the term of mentalization. From this evidence base, we will adapt the staging model of SSP progression in function of our mentalization-informed model, tailored to provide a coherent framework of care addressing the key clinical needs at every stage of psychosis progression.

The practice of diagnosis is fundamentally designed to orient treatment. In the case of early diagnosis for schizophrenia spectrum disorders (SSP) risk, the empirical base for such a practice is still young, and many clinical questions arise in the everyday clinical application of risk algorithms and ensuing therapeutic options. One of the key questions that we will focus on is the following: in cases of SSP where symptoms are successfully treated, why does residual social functioning impairment remain the most serious obstacle to remission and reinsertion in society? We will present the evidence suggesting that the roots of residual social functioning impairment may, in many cases, come from thwarted or arrested development in the specialization of social cognition during adolescence and early adulthood. We will review the evidence suggesting that both during the premorbid phase and clinical high-risk phase, attenuated psychotic symptoms may impede the maturation of key social cognitive processes, particularly the suite of reflective thinking processes coming under the term of mentalization. From this evidence base, we will adapt the staging model of SSP progression in function of our mentalization-informed model, tailored to provide a coherent framework of care addressing the key clinical needs at every stage of psychosis progression.
Keywords: schizophrenia, treatment, early intervention, mentalizing, social functioning BACKGROUND In its short history, the topic of early diagnosis for clinical high-risk states to develop psychosis (CHR-P) has stirred both hope and controversy. Early diagnosis aiming to shorten the duration of untreated psychosis (DUP) proved valuable to improve outcome along the clinical course of schizophrenia spectrum disorders (SSP) (1). Powered by research on DUP, attempts to characterize the psychological risk states preceding psychosis were received with both enthusiasm and opposition. While an early diagnosis of prodromal states could justify indicated preventive treatment, intense debate and vigorous opposition appeared fuelled by concerns for the validity of the risk constructs, fear for diagnosing false positives and for the effects of labelling (2). Today, expert consensus puts forward validated tools to clinically assess CHR-P states preceding the onset of SSP (3); the clinical practice of these tools and the initiation of early treatment is currently exerted with caution (4). In this article, we wish to reframe the questions surrounding early diagnosis and early treatment to the following question: which type of clinical care is needed at different stages of the progression of psychosis? A central empirical finding will guide our discussion on this question: regardless of symptomatic remission in SSP, residual social functioning impairment remains the most serious obstacle to full recovery and reinsertion in society. We will present the evidence suggesting that the roots of residual social functioning impairment may, in many cases, come from thwarted or arrested development in the specialization of social cognition during adolescence and early adulthood. We will review the evidence that many factors along the preclinical phase of psychosis may impede the maturation of key social cognitive processes, particularly the suite of reflective thinking processes coming under the term of mentalization. From this evidence base, we will revise the staging model of psychosis progression, and outline our mentalization-informed approached tailored to provide a coherent framework of care addressing the key clinical needs at every stage of psychosis progression.

WHY EARLY DIAGNOSIS?
In the past quarter of a century, research on the risk of developing schizophrenia spectrum and other SSPs [Diagnostic and Statistical Manual of Mental Disorders (DSM-5)] has dramatically transformed our clinical and scientific approach to what Eugene Bleuler referred to as the « schizophrenias » (5). In concert with emerging findings in developmental neuroscience, these disorders, which we regroup under the rubric of SSP, are now conceptualized as neurodevelopmental in origin (6). Importantly, expert agreement situates the development of SSP along four distinct periods: the premorbid phase, the clinical high-risk states, the first episode of psychosis, and the trajectories following the first diagnosis (7). The asymptomatic premorbid period during childhood and adolescence can be characterized by non-specific impairments in cognition (8), infra-clinical manifestations of trait risk such as negative and positive schizotypy or subtle cognitive disorganization (9)(10)(11), as well as slight social cognitive impairments (12,13). The pathogenesis can evolve from the premorbid phase to a subclinical stage of risk symptoms preceding the actual onset of the disorder. These risk symptoms represent CHR-P states, which are reliably diagnosed through the use of validated instruments such as the CAARMS (Comprehensive Assessment of At-Risk Mental-States) (14), the SIPS (Structured Interview for Prodromal States) (15), and the SPI-CY/SPI-A for basic symptoms (Schizophrenia Proneness Instrument-Child and Youth version or Adult version) (16). Questions of diagnosis and early treatment are most controversial during this phase (17), when rates of CHR-P individuals not developing SSP can be high (18), diagnostic procedures focusing on different types of manifestations (19), notwithstanding that clinically speaking, the recognition of the psychotic nature of the risk may be difficult to perceive for the young person and her/his family.
Once a diagnosis of psychotic disorder is established, the treatment guidelines are clear (20), and potential issues with these guidelines lie beyond the scope of this article. Hence, the most debated issue of early diagnosis and treatment lies within the CHR-P period, and as we will suggest, can be extended to questions surrounding early prevention strategies in the premorbid phase. The diagnosis of CHR-P states, while widely practised and accepted by experts in the field, still fosters debate (21). While a categorical diagnosis of Attenuated Psychosis Syndrome (which correspond broadly to the CHR-P state) has been recently added in the section 3 of the DSM-5 (22), concerns for over-diagnosis are currently being researched (23), and conceptual debates confronting categorical versus continuum views of psychosis remain vigorous (2,24).
The question of early treatment is closely linked to that of early diagnosis for a simple reason: ideally, a diagnosis should indicate clear treatment rationale and options. Yet in the present state of scientific advancement, research for treatment in CHR is only nascent (25). Additional issues originate from the point of view of public health: in many countries, health care systems will allocate resources to patients on the condition of a recognized medical diagnosis. In such instances, economic and political forces can both push for and/or pull away from the recognition of a condition (26). As it stands before the turn of the decade in 2020, the diagnosis of CHR (DSM-5) is still under observation, and as we have briefly summarized, a number of issues residing outside of the purely diagnostic debate still remain. While the question of early diagnosis is still open, an increasing number of studies point to two complementary pieces of evidence: 1) individuals diagnosed with a CHR-P state, but that do not transition to psychosis, still require clinical attention (27) and have worst outcome compared to those who didn't experienced a CHR-P (28); 2) longitudinal research does not overwhelmingly support the notion of transition to psychosis as a key predictor of functional outcome (29). This poses the questions of the clinical needs of individuals with sub-threshold psychotic symptoms and comorbid disorders, and furthermore, which kind of treatment would be adapted to their clinical profiles.

THE RATIONALE FOR EARLY TREATMENT
One of the issues reaching beyond diagnosis relates to the question of whether treatments can be offered to people before the onset of psychosis, and if so, what should be the main measure of outcome to judge their efficacy?
A recent meta-analysis of psychological and psychopharmacological randomized-control trials (RCTs) for individuals meeting the established criteria for CHR-P states a clear and structured perspective on the studies performed over the past 10 years (4), also pointing to areas of potential amelioration in both research and clinical work with CHR-P. The meta-analysis focuses on the conversion rate to psychotic disorder as the principal outcome of their analysis, and further considers functional improvements as a key outcome to studies with these populations. Schmidt et al. find evidence that early intervention provides significant benefits to individuals at CHR-P in terms of either significantly preventing or delaying the emergence of a psychotic disorder. This result has been supported by more recent meta-analyses on early treatment with CHR-P (30).
Interestingly, however, the available meta-analyses examining early treatment during CHR-P find no treatment superiority effects when comparing psychological vs neuroleptic medication, nor any superiority effect within the different psychological treatments under study (4,25,30). The variety of types of treatment, at this stage, is moderate. In addition to psychopharmacological trials, RCTs have been performed for nutritional supplements, cognitive behavioural treatment, multifamily psychoeducation, and combined interventions with additional social skills training. Despite the important differences in methodology, no superiority effect was found for treatment type; this is consistent with recent reports on the "Dodo bird effect" in psychotherapy, using a variety of therapy models, for a variety of different psychiatric conditions (31). Perhaps most intriguing is the lack of superiority to control conditions with regards to functional improvements. Indeed, while specialized early treatment methods significantly decrease the transition rate to SSP, functional outcomes are roughly equivalent to those obtained through control conditions. It appears, therefore, that room for improvement in early treatment for psychosis is most apparent in the area of functional outcomes.

CONCERN FOR FUNCTIONAL OUTCOMES AND THE RELEVANCE OF A DEVELOPMENTAL MODEL
In many different domains of mental health treatment, a discrepancy can be observed between, on the one hand, an individual's symptomatic improvement with treatment, and on the other hand, the same individual's stability or worsening of adaptive functioning. In SSP, the functional outcome or global functioning beyond symptom severity represents the sum of several different but correlated domains, such as cognitive, role and social functioning. Further, several studies suggest that impairments in social functioning create the most disability in SSP. Conversely, the "symptom-disability gap" observed over the course of treatment is often portrayed in the treatment of SSP (32). This gap is not unique to SSP, it can also be observed in other conditions, for example attention deficit hyperactivity disorder (ADHD) (33). The symptom-disability gap creates a clinical puzzle: how can interventions that attenuate symptoms fail to produce positive cross-over effects into functional improvements? Treatment for individuals with the full diagnosis of schizophrenia have provided the clearest examples of the symptom-disability gap: indeed, it is estimated that social functional impairments characterize more than half of patients with treatment (34). While symptoms appear to respond to medication, patients often fail to benefit from improvements in their daily-living conditions.
In SSP, the issue of intact impairment of social functioning regardless of treatment also seems to apply to treatment for earlier stages of the disease, notably treatment for youth at CHR. In a recent meta-analysis of early interventions for youths at CHR for psychosis, Devoe et al. specifically examine the effect of preventive treatment on social functioning (35). The meta-analysis included 19 trials encompassing 1,513 patients meeting diagnostic criteria for CHR-P. Neither cognitive behavioural trials, nor omega-3 trials and cognitive remediation trials significantly improved social functioning in youth at CHR-P. The authors remark on the need to adapt early interventions to the domains of functioning, namely social functioning, that require support in the early stages of psychopathological progression to psychosis.
As we have argued elsewhere (36,37), targeting social cognition in early interventions constitutes a challenging ambition, especially in the case of youths at CHR-P. Firstly, decades of research on socio-emotional development during adolescence and early adulthood suggest that a number of different processes interact to promote growth and socially adaptive behaviour. In parallel, cerebral maturation during the same age period will sculpt the morphological brain areas, contribute to the specialization of skills needed to function at high levels of social complexity, and fuel the integration of complex neuro-functional networks that will sustain continued maturation of social functioning skills (38,39). Critically, within this same period of adolescence and early adulthood, youths in the premorbid stage can already show signs of subtle impairments on a range of skills sustaining social cognition, that is, the set of skills that enable to perceive, analyse, interpret and select adaptive behaviours in interpersonal and social contexts (40,41). This set of skills can be subsumed under the construct of mentalization, that is, the suite of social cognitive imaginative activity enabling the interpretation of behaviour in terms of intentional mental states (42). Mentalization confers the possibility of imagining the intentions, emotions, motivations, and beliefs behind others' actions, as well as behaviours of oneself that are more complex to understand or justify. It is crucial for social understanding and adaptation and, in evolutionary terms, it is thought to have evolved out of the need for human collaboration and competition (43). Thinking about mental states underlying individual actions can provide the necessary tools for anticipating behaviour, understanding relationship patterns, and adapting to different types of social environments (44). Recent neuroscientific research has shown how adolescence constitutes a key developmental window for the integration of the neuro-functional networks that articulate the processes to sustain accurate mentalizing (44)(45)(46).
In a similar line of thought, but focusing on the origin of social cognitive impairments in clinical samples, current research points out that the relationship between impaired social cognition and psychosis does not originate from secondary deficits associated with chronic psychosis, nor does it constitute a consequence of first episode psychosis, because impairments in social cognition are already apparent during the stage of CHR-P (47), and can be found to be predictive of conversion to psychosis, notwithstanding that more subtle impairments have been associated to the premorbid phase (48)(49)(50). In parallel, several reports have suggested subtle early impairments in a number of different social cognitive processes contributing to mentalizing. From the point of view of neurodevelopment, aberrant maturation of the right superior frontal, middle frontal, and medial orbitofrontal predict conversion to psychosis in CHR-P (51); these regions are best known to sustain mentalizing (52). Behavioural evidence of developing mentalizing skills in youths suggest, first, that in 11-12 year olds who report auditory verbal associations (a symptom of positive schizotypy), present faulty inferences of others' mental states in the form of hypermentalizing (12,13), that is, providing mentalistic assumptions clearly beyond the available evidence. Second, a number of studies reports impaired mentalizing in youths showing either trait risk, such as high schizotypy scores (53,54), or state risk, such as CHR-P (55,56). In a recent study on 632 CHR-P participants aged 12-35, evidence for reduced theory of mind (mentalizing the mind of others) could be evidenced as of 17 years of age (57), suggesting that adolescents and young adults with CHR-P can experience significant difficulties in understanding phenomena such as sarcasm and lies, which require specialized mentalizing skills that mature during adolescent development.
The nature of the relationship between impairments in social cognition and manifestations of psychosis from the premorbid to the clinical stages of expression still remains unclear. If the developmental process of social cognition is independent from the pathogenesis process of psychosis, then impaired social cognition may simply reflect the impact of pathogenesis at every stage in association to neurodevelopment (49). If impaired social cognition interacts with pathogenesis, as hypothesized by several authors including Paul H. Meehl's theory of schizotypy (58,59), then the best explanatory model would be one of the interacting processes leading to psychopathological outcome.
Another hypothesis, complementary to the first two, which stands on the idea of a synergy between psychotic symptoms and lack of social cognition, has recently been put forward by our group: we may conjecture that progressing psychotic pathogenesis impacts the very development of social cognitive processes, and vice versa (37). Indeed, the expression of negative schizotypy such as in physical and social anhedonia, social anxiety and social withdrawal may each impact the very opportunities of interpersonal and social interactions during adolescence and young adulthood. Anhedonia affects the motivational system responsible for triggering anticipated interest in interpersonal exchange, and impedes the allowance of cognitive resources to understand how minds work and how they influence behaviour. Social anxiety will affect the behavioural predisposition to seek out interpersonal and social exchange by fostering social avoidance. Finally, social withdrawal may affect the establishment and maintenance of close interpersonal relationships, a context in which significant interpersonal and social understanding can be experienced and deepened. Thus, many of the key manifestations in distal risk for psychosis (60) already affect the creation of the psychological tools to seek, participate in, and understand the interpersonal social world.
In the opposite but complementary direction, the development of mentalizing seems to confer a protective role in those individuals at risk of developing psychosis. In a longitudinal study among children experiencing auditory hallucinations at ages 7-8 and/ or 12-13, Bartels-Velthuis et al. found that the development of delusional ideation secondary to abnormal perceptual experiences (AVH) was reduced when participants demonstrated strong mentalizing skills (61), hinting to the protective nature of strong mentalizing skills early in development. Furthermore, robust mentalizing may also reduce the distress caused by psychotic symptoms, as suggested recently by Peters et al. (62). In this original study comparing non-schizophrenic but persistent voice hearers to voice-hearers with schizophrenia and to non voice-hearing controls, the study investigated which kind of features might reliably distinguish between these three groups. While testing for a variety of clinical, socio-demographical and psychological characteristics, the study, which enrolled almost 100 participants in each group, found that the only psychological process distinguishing persistent but non-schizophrenic voice hearers from both controls and voice-hearers with schizophrenia was mindfulness, as measured by the Southampton Mindfulness Questionnaire (SMQ) (63). Indeed, the non-clinical voicehearers reported higher mindful responding to internal thoughts and images in comparison to clinical voice-hearers, but what is more surprising is their increased mindfulness skills in comparison to controls. Mindfulness is directly linked to mentalizing one's own thought content, and cultivating a relationship of curiosity and acceptance with the production of one's mind (64). This study underlines that mentalizing others, as measured in ToM tasks, is not the only dimension of mentalizing that is key to resilience processes. Indeed, as we have suggested elsewhere, mentalizing oneself may be especially important in relation to risks for psychosis, because individuals on the clinical continuum of psychosis experience disturbing stimuli that is self-generated (self-criticism, paranoia, thought disorganisation, or disturbing sensory or perceptual experiences for example) that do not temporally respond to contingent and upsetting emotional stimulation by others, more typical in emotional arousal observed for borderline personality disorders (36,37). As suggested by these reports and others [for a review, see Ref. (37)], both self and other mentalizing may thus constitute potent protective factors in the face of risk for psychosis. These different strands of evidence also underline the utility of the concept of mentalization, which unifies different psychological constructs related to thinking about mental states into a coherent framework articulated to a therapy model (65,66).
Indeed among the therapeutic models adapted to focus on the early impairments in social cognition, Mentalization-Based Therapy (MBT) constitutes an integrative intervention first developed to address psychotherapeutic treatment for Borderline Personality Disorder (BPD), and more recently successfully adapted to psychological treatment for the most severe psychopathologies in adolescents and adults (67,68). The model aims to increase the client's capacity to mentalize, that is, to identify mental states in oneself and others, and reflectively assess their contributions to patterns of dysregulated behaviour, emotional reactions, or maladaptive thought patterns. Three main reasons would sustain the pertinence of such a model for psychosis along its different stages of clinical evolution. First, recent studies on MBT adapted for patients with non-affective SSPs have shown feasibility and promising results (69,70). Furthermore, MBT has proven to be effective in adolescent conditions which typically present sub-clinical psychotic symptoms (68). As such, the same model of therapy is applicable to the range of clinical manifestations along the continuum of psychosis expression. Randomized controlled trials (RCTs) conducted with patients suffering from borderline personality disorder have shown its therapeutic effect on interpersonal relationships and emotion regulation processes (71)(72)(73). More recently, MBT has been successfully adapted to a range of disorders (74), and interestingly, an increasing number of reports relate successful attempts to adapt MBT for CHR-P (36,37) and SSP (75)(76)(77). In line with this preliminary evidence, we next sketch out a mentalization-informed staging approach to psychosis, from the premorbid to the full diagnostic conditions.

A MENTALIZATION-INFORMED STAGING APPROACH TO PSYCHOSIS
Broadly speaking, the clinical staging model is a transdiagnostic heuristic approach aimed at understanding the neurobiological and environmental processes underpinning the onset and course of a disorder. Clinical staging, through integrating stage and timing with evolution of clinical phenotype, also allows interventions to be tested from a preventive standpoint in reducing the risk of progression and persistence of illness. The idea of a clinical staging approach for psychosis as a progressively intensive intervention model aimed at prevent/delay the transition to psychosis in CHR-P subjects has been firstly developed by McGorry and colleagues more than 10 years ago (78). This model was originally focused on preventing the progression of psychotic symptomatology through different levels of intervention (starting from psychosocial interventions up to antipsychotic medications), in accordance with the severity of the symptomatology. Even if the most recent developments of the clinical staging model for psychosis (79) have broadened the outcomes of interest moving from symptoms to functioning, the proposed interventions are more focused on treating symptoms instead of intervening directly on psychological processes that sustain resilience, such as mentalization.
In accordance and as a consequence of the hypothesis that we formulated in the previous section, we propose a revised staging model, which is more focused on treating the progressive delay/impairment in social cognition (social functioning) alongside the monitoring of potentially progressing psychotic (and others) symptoms. As showed in Table 1, together with the clinical progression of the psychotic symptomatology from stage 0 (subtle, subjective, non clinical pre-psychotic experiences such as psychotic-like experiences (PLEs), anomalous self experiences (ASE), basic symptoms (BS), NSS) to stage III (chronic psychosis), we propose a model of progressive impairments mentalizing skills which filtrates in parallel (in synergy) to progressing symptomatology. This progression starts by slightly affecting interpersonal, academic and social functioning, may increase by perturbing the ability to interpret social interactions (further affecting interpersonal, academic, and social functioning), and can lead to an arrest in the development of mentalizing competences, with ensuing consequences much later in the outcome of trajectories with psychosis.
In Table 2, we attempt to provide an overview of a coherent and progressive MBT intervention model (MBT CHR-P) aimed at sustaining the development and safeguarding against impairments in mentalizing abilities in patients putatively at-risk for psychosis, at each stage of the clinical progression ( Table 1). Broadly speaking, this intervention model is based on the 5 principles of the clinical staging model for CHR-P. Firstly, a staged approach to treatment is offered, with low intensity and least specialized interventions used initially, and "stronger, " Co-morbidity as a rule Severe and chronic impairment in social and professional functioning; no or limited recovery more intensive interventions, reserved for those who do not respond to the earlier stages of intervention. In line with this approach and with the original clinical staging model for CHR-P, medications are considered as a possible intervention only starting from stage Ib. Moreover, there is still a lack of evidence concerning the efficacy of medications such antipsychotics or other molecules (eg. Omega-3 fatty acids; NAC) to prevent/ delay transition to psychosis (80). Secondly, this strategy should address the problem of the low transition rate to psychosis (2). Indeed, this strategy is primarily addressed at improving mentalizing abilities and consequently the clinical and social functioning needs instead of mainly avoiding transition to psychosis. Nevertheless, this latter remains one of the targets of the model. Thirdly, this model is based on the hypothesis that the efficacy of therapeutic interventions that strengthen resilience (such as MBT) is closely correlated to the timing of the intervention. In this sense, the developmental phase (i.e. age, psychological maturity) as well as the stage of the disorder must be taken into account to decide the type of intervention. Fourthly, the model seeks to enhance compliance by addressing the therapeutic objectives of the patient themselves in the treatment formulation, which do not necessarily include attenuated psychotic manifestations, but issue such as patient-reported sources of distress such as anxiety and social functioning (81). In line with the fourth principle, this staged approach addresses ethical concerns, namely the potential stigma, the "false positive" issue, and a perceived relative lack of predictive power, by adapting the intervention to key clinical targets at every stage. We further attempt to integrate notions of primary and indicated selective prevention within the MBT-informed care plan. Referring again to Table 2, interventions for stage 0, a stage characterized by less severe and less specific clinical phenotypes, are tailored on the primary prevention that aims the education sector (82). In this early phase, interventions are provided at school and family levels and are aimed at sustaining the development of mentalizing skills and fostering a mentalizing environment which has a number of transversal benefits, such as reducing bullying and violence in schools (83,84), and therefore may be relevant to legislators that would be less sensitive to a psychosis-targeted primary prevention program. The focus at this stage is really to enrich the traditional pedagogical stance with some mentalizing knowledge, and certain current schoolsbased experiments focus on integrating a mentalizing perspective within the educational context (85).
Moving along in Table 2, Stage Ia and Ib provide a progressively more intensive and specific intervention based on the MBT-adolescents (MBT-A) and MBT-family (MBT-F) model, along a selective prevention principle (36). MBT-A program and MBT-F are manualized, psychodynamic psychotherapy programs with roots in attachment theory [for descriptions of the interventions, see Refs. (68,86,87)]. During stage Ia, this intervention will be mostly provided for short periods and in a group setting. It involves weekly individual MBT-A sessions and monthly mentalization-based family therapy. During stage Ib, the MBT-A program will become more intensive and mostly structured on individual setting. In stage II and III, progressively more specific MBT intervention for SSP, such as MBT-G [see Ref. (69)] for psychosis and Adaptive Mentalization Based Integrative Treatment (AMBIT) (67,88), which guides multidisciplinary teams working with hard to reach clinical cases using case manager models of care. Overall, the mentalization-based approach to clinical staging of psychosis provides a coherent theoretical and clinical framework. This framework affords two key advantages: it provides a clinical intervention that is suited for both the psychotic related symptoms, but also the other psychiatric comorbidity issue that ultimately influence the severity of clinical outcome. Second, it provides a framework for training professionals that is applicable to a range of professionals who are susceptible to intervene at different stages of the progression of psychosis, from educators to general practitioners, as well as case managers, psychiatric nurses, psychologists and psychiatrists. The MBT model is based on the past 20 years of empirical research in child, adolescent and adult clinical interventions (89,90). With regard to early diagnosis and treatment, the mentalization-informed model of staging we present here is specifically designed to promote development and prevent impairments in the key social cognitive processes before the onset of psychosis, in order to respond to the clinical needs of individuals "at-risk, " and further to attempt to ameliorate the poor long-term outcome of social functioning should individuals evolve towards a diagnosed psychotic disorder. Nevertheless, at this stage, the proposed MBT intervention based on the clinical staging model still needs to be tested and evaluated in clinical settings. Indeed, while there are some preliminary reports on the efficacy of MBT in FEP and in SSD (69,91), there is still a lack of evidence concerning the ability of this intervention to reduce the transition to psychosis and ameliorate social functioning in patient at CHR-P (36).
Consequently, the usefulness of MBT in these early stages should be tested empirically with pilot randomized singleblind superiority trials comparing the efficacy of the MBT model with TAU in CHR-P adolescent population on several targets. Indeed, such trials should test firstly the 1) acceptability and attrition rate of the MBT model. Secondly, the efficacy of MBT in improving 2) mentalization abilities and 3) social functioning in CHR-P patients indipendently to transition to psychosis should confirmed. Thirdly, the efficacy of MBT in reducing 3) severity of psychotic symptoms and 4) transition to psychosis rates should be investigated. As a fourth step, the presence of biological substrates of the effect of MBT such as stress hormones and brain function (f-MRI) should be investigated in order to confirm the validity and the specificity of the MBT model.

CONCLUSION
In providing a mentalization-informed framework for the staging of CHR-P and transition to psychosis, we attempt to target a key problem in the treatment of SSP, namely, the symptom-disability gap in outcomes of treatment where individuals still suffer from poor social functioning. We argue that the roots of residual social functioning impairment may, in many cases, come from thwarted or arrested development in the specialization of social cognition during adolescence and early adulthood. Our approach is also pragmatic, and sensitive to the cases of "non-conversion" to psychosis, for which important clinical care is still needed. Much of the clinical practice in developmental psychopathology is performed under conditions of uncertainty as to the symptomatic evolution and clinical outcome of individuals seeking help. Further clinical research that integrate the principles of good practice in the respect of empirical evidence will further sculpt the tools and methods of early diagnosis and intervention, to provide the most adapted care plan sustaining the development of the individual while attempting to divert the negative impact of psychosis progression on the interpersonal and social functioning domains, which today represent the key obstacles to therapeutic success with psychosis.

AUTHOR CONTRIBUTIONS
All three authors contributed to writing the manuscript.