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Rac1 regulates nucleus pulposus cells degeneration and promotes the progression of intervertebral disc degeneration.

Nucleus Pulposus Cells (NPCs) dysfunction is considered as an important event related to intervertebral disc degeneration (IVDD). In the present study, tandem mass spectrometry (TMT) was used to detect total protein expression of NP in patients with IVDD and healthy controls. Bioinformatic analysis was performed to identify differentially expressed proteins that may be involved in the degeneration of NP. The results show that Rac1 may be a key protein involved in the degeneration of NP via Wnt/β-catenin pathway activation. We investigated the influence of Rac1 on IVDD degeneration and associated mechanisms. This study has the potential to advance understanding of the mechanism of occurrence of degenerative NP tissues and provide novel strategies for slowing IVDD progression.