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Correlation between ocular response analyzer (ora) and dynamic contour tonometer (pdct) parameters in normal subjects and in glaucoma patients

Purpose: The ORA measures corneal biomechanical properties: CH and CRF. The PDCT measures OPA, the systolo-diastolic variation of IOP. Both ORA and OPA values are lower in glaucoma than normal patients. Our purpose is to assess if there is a correlation between ORA and OPA values, and to compare these values between normal and glaucoma patients. 
 
 
 
Methods: 40 adult healthy volunteers (group1: G1) and 42 glaucoma patients (group2: G2) underwent prospectively consecutive 4 ORA, 3 OPA and 2 GAT measurements. Patients with previous refractive or intra-ocular surgery, contact lenses were excluded for both groups. Also, patients with ocular eye disease, topical or general medications were excluded for G1. 
 
 
 
For each device, the mean of the measurements for one randomised eye in G1 and for the more affected eye in G2 was used for statistical analysis. Pearson correlations were used. Comparisons of the two groups mean values were made with a two-tailed Student’s t test. 
 
 
 
Results: 82 eyes of 82 patients. The mean age for G1 and G2 was respectively: 43.6±14.6 and 65,1±13,6 years. The mean IOP was higher in G2 ( p <0.001) for the 3 devices, with no difference in CCT. CH ( p <0.001) and CRF ( p= 0,028) values were lower in G2. OPA was higher in G2 ( p =0,014). The OPA/CH and OPA/CRF Pearson correlations were respectively: r=0,079, p =0,627 and r=0,258, p =0,108 for G1, and r=-0,116 p =0,463 and r=0,180 p =0,253 for G2. 
 
 
 
Conclusions: We did not find any statistical significant correlation between corneal biomechanical properties and the OPA values either in normal or in glaucoma group. We found lower corneal biomechanical properties in glaucoma than in normal group.