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The increase in cytosolic levels of protein kinase C precedes the growth factor requirements during the transition stem cells to differentiated progeny in the MCF‐7 breast tumor cells.

The expression of regulatory genes within the context of a differentiation program can have profound long‐term consequences in tissues with permanent renewing populations. The breast tumor cell line MCF‐7 retains in culture some of the characteristics of a unidirectional differentiation pathway. We show that the cytosolic activity of the regulatory enzyme protein kinase C (PKC) precedes and continues the sequence of maturation in pre‐differentiated subpopulations derived from a stem cell fraction. However, the activity declines in the most differentiated, post‐mitotic fraction. These results indicate that PKC may be considered among the regulatory genes in MCF‐7 cells that specify maturation of the stem cell progeny.