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Inactivation of the NF2 tumor suppressor protein merlin in DU145 prostate cancer cells

The neurofibromatosis 2 (NF2) tumor suppressor gene product merlin is an important regulator of contact‐dependent cell proliferation. Phosphorylation of merlin at serine 518 (Ser518) by the Rac effector p21‐activated kinase (PAK) inactivates merlin's growth suppressing function, and is regulated by cell‐culture conditions, including cell density, cell/substrate attachment, and growth factor availability. We examined the regulation of merlin expression and merlin phosphorylation in prostate cancer cells.