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A highly integratable microfluidic biosensing chip based on magnetoelastic-sensor and planar coil

This paper presents a novel lab-on-a-chip type bio-sensing system that is comprised of magnetoelastic (ME) biosensor, planar coil, and microfluidic system. The novelty of this system is to integrate planar coil to wirelessly actuate and detect the ME biosensor. Compared with solenoid coil that is traditionally used to measure ME sensors, the two-dimensional planar coil made by micro-fabrication process shows advantages of easy miniaturization and integration. The ME-sensor based microfluidic-chip was fabricated. By assembling poly-L-lysine coated ME biosensors into the chip, real-time in-liquid detection of yeast cells at different concentrations was successfully performed. The results showed that continuous decrease in the resonant frequency of the ME biosensor was observed as yeast cells were attaching on the sensor surface. Significant frequency shifts were obtained when the cell binding reached equilibrium. With the in situ real-time bio-sensing capability, this highly integratable system shows great potential of being used for rapid and low-cost bio-analysis.