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The Treatment of Urinary Candidosis with the Oral Antifungal Drugs 5–Fluorocytosine and ‘Clotrimazole’

Five children with congenital anatomical abnormalities were treated orally with 5–fluorocytosine for severe urinary candidosis, following prolonged anti‐bacterial therapy. Dosage was started at 50mg/kg/day at 6–hourly intervals and was continued for 4 to 6 weeks. Numerous serum and urine assays were made. Urine samples soon became negative on microscopic and cultural examination, except in one case where a more resistant variant of Candida appeared during therapy, necessitating a higher dosage. No clinical, haema‐tological or biochemical side‐effects were noted.