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Articles of Significant Interest Selected from This Issue by the Editors

Ehrlichia chaffeensis is an obligate intracellular bacterium that parasitizes macrophages. With a genome of about 1 Mb and containing no plasmids, this bacterium has frustrated attempts at genetic manipulation. Likewise, the host factors required for replication are mostly a mystery. Von Ohlen et al. (p. 3576 –3586) reveal host mitochondrial biochemical pathways and molecules necessary for infection. These include the processing of pyruvate to provide acetyl coenzyme A, pathways that provide enzymes and substrates for the production of cytidine diphosphate-diacylglycerol, and the release of cytochrome c from mitochondria. The data help explain why mitochondria cluster around morulae, the sites of bacterial replication, in cells parasitized by E. chaffeensis.