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Articles of Significant Interest in This Issue

Per-Oral Vaccination Induces IgA Secretion in the Female Reproductive Tract and Protection against Vaginal Chlamydia Challenge in Mice Chlamydial infections in women cause reproductive tract pathologies and infertility. There is no effective vaccine against this pathogen. Shillova et al. (e00413-20) show that per-oral immunization with live or killed Chlamydia muridarum protects against vaginal challenge, reflected in reduced Chlamydia burden and reproductive tract pathology. Secreted IgA induced by per-oral immunization neutralizes Chlamydia, thus lowering infectivity, hindering ascension to the upper reproductive tract, and accelerating Chlamydia clearance. The authors propose that the gut-associated lymphoid tissue is the inductive site for reproductive tract B cell responses and that per-oral immunization may also be effective for developing vaccines against other sexually transmitted pathogens.