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Infiltrating cells and related cytokines in lesional skin of patients with chronic idiopathic urticaria and positive autologous serum skin test

Abstract:  In approximately one‐third of patients with chronic idiopathic urticaria (CIU), autoantibodies against the high‐affinity IgE receptor and/or against IgE can be detected and a wheal‐and‐flare response can be provoked by the intradermal injection of autologous serum (ASST). In this study we aimed to further characterize the inflammatory response observed in the subgroup of CIU patients with positive ASST and serum‐evoked histamine‐release in vitro from basophils in comparison with unaffected skin and healthy donors. An immunohistochemical analysis of infiltrating cells (CD4, MPO, EG1, EG2, tryptase), cytokines (IL‐4, IL‐5, IFN‐γ), chemokines and chemokine receptors (IL‐8, CCR3, CXCR3), and adhesion molecules (ICAM‐1, VCAM‐1, ELAM‐1) was performed on seven selected patients (four males and three females; median age: 45 years; range: 22–57) and five healthy donors. Cytokine evaluation was also performed in five psoriatic patients to obtain an additional control.