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Improvement in Pharmacokinetic Parameters of Ibuprofen by Crystal Engineering Approach

Purpose: The aim of present work was to improve the pharmacokinetic parameters like Cmax, Tmax, and AUC of Ibuprofen by crystal engineering approach. Methods: Ibuprofen crystals were prepared by conventional solvent evaporation process in presence of saccharin sodium excipient at room temperature. The Ibuprofen crystals were evaluated by in-vivo study and the results obtained were compared with the pure drug. Results: In-vivo pharmacokinetic study was carried out by using albino wistar rats which shows the improvement in 2.95 folds higher plasma concentration from Ibuprofen crystals compared to the plain drug. One group of rats treated with pure drug i.e., Ibuprofen suspension (STANDARD) while the other group of rats treated with Ibuprofen loaded crystals (TEST). The results revealed that the plasma concentration-time profile of standard group and test group depicted the Cmax of 16181.12 ng/mL and 29585.68 ng/mL while Tmax of 90 minutes and 30 minutes, and AUC found was 44816.86 ng*h/mL and 132080.30 ng*h/mL respectively. Conclusions: The crystal engineering approach can be used as a tool to improve the pharmacokinetic parameters of BCS Class-II drugs. © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Vaghela, P.D.; Tank, H.M. Improvement in pharmacokinetic parameters of ibuprofen by crystal engineering approach. Indo Global J. Pharm. Sci., 2020; 10(1): 19-24. DOI: http://doi.org/10.35652/IGJPS.2020.10103 . Indo Global Journal of Pharmaceutical Sciences, 2020; 10(1): 19-24 20 Pharmacokinetics of Ibuprofen includes rapid absorption through the gastrointestinal tract and peak plasma level is achieved within 1-2 hours after the oral administration of 200400 mg dose and the concentration appears in the blood circulation is about 15-25 mg/mL. Ibuprofen has extensive protein binding capacity and is excreted via kidneys. The biological half-life is about 2-3 hours. Ibuprofen is used primarily as an anti-inflammatory, to treat fever, mild to moderate pain after surgery, osteoarthritis, toothache, painful menstruation and headache [15]. It is used as an anti-inflammatory drug and it can be employed in juvenile as well as rheumatoid arthritis and also in pericarditis [16-18]. MATERIALS AND METHODS