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Fixed drug eruptions: a case report and review of the literature.

Fixed drug eruptions (FDEs) have been described since 1889 with continually evolving documentation of implicated agents and clinical presentations. We report a case of FDE as a reaction to naproxen sodium in a 27-year-old woman. We offer an inventory of common causes of FDEs as well as a discussion of the spectrum of clinical presentations and differential diagnoses for this peculiar drug reaction.