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Atrial fibrillation compendium: historical context and detailed translational perspective on an important clinical problem.

### Circulation Research Compendium on Atrial Fibrillation:

Atrial Fibrillation Compendium: Historical Context and Detailed Translational Perspective on an Important Clinical Problem 

The Clinical Profile and Pathophysiology of Atrial Fibrillation: Relationships Among Clinical Features, Epidemiology, and Mechanisms

Emerging Directions in the Genetics of Atrial Fibrillation

Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance and Progression

Role of the Autonomic Nervous System in Atrial Fibrillation: Pathophysiology and Therapy

Mathematical Approaches to Understanding and Imaging Atrial Fibrillation: Significance for Mechanisms and Management

Atrial Fibrillation Therapy Now and in the Future: Drugs, Biologicals, and Ablation

Guest Editor: Stanley Nattel 

Atrial fibrillation (AF), the most common sustained tachyarrhythmia, currently affects 1% to 2% of the general population.1 Age is arguably the strongest determinant of AF occurrence, and the prevalence of AF is increasing as the population ages, projected to increase from ≈7 million today to ≈12 to 16 million predicted for the United States in 2050 (including estimates for paroxysmal and silent AF).1 There has been a marked progress in our understanding of the basic mechanisms underlying AF for the past 20 years.2–5 The management of AF continues to face huge challenges, but advancing knowledge and new technologies have also created unprecedented opportunities, which will undoubtedly revolutionize AF management over the next 20 years.6 Recognizing the importance of this area and the rapid pace of knowledge development, the Editorial Board of Circulation Research decided to develop a Compendium on Atrial Fibrillation. The compendium includes 6 state-of-the-art review articles on themes of clinical features and pathophysiology of AF,1 molecular electrophysiology of AF initiation, maintenance, and progression,7 autonomic nervous system control of AF,8 genetic factors determining AF occurrence and risk,9 the use of mathematical modeling to understand and manage AF better,10 and the mechanisms governing present and future therapy of the arrhythmia. …