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Renal Cadaver Transplantation Followed by Successful Pregnancies

Twenty-three cases have been reported in which pregnancy and delivery have occurred in patients with renal transplants. We add 2 cases, bringing the total to 25. Eight of the 25 cases, including the 2 reported here, have received cadaver renal allographs. Labor obstruction due to the kidney is uncommon but has occurred on 2 occasions. Premature rupture of the membranes occurred in 20% of cases. The mean length of the transplant-pregnancy interval has been 16.8 months. Although there have been reported cases of chromosomal abnormalities and one instance of a birth defect in the children of mothers on imunosuppressive drugs, the infants have done well. Mean infant birthweight was 2470 g. Renal function during pregnancy does not appear to have been seriously jeopardized.