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Modulation of biomarkers in minimal breast carcinoma

The widespread use of diagnostic breast imaging has yielded an increase in the detection of in situ, microinvasive, and small invasive carcinomas and has provided opportunities to study the earliest stages of breast carcinoma development. The authors of this report analyzed the pathobiologic features of 577 minimal breast carcinomas (MBCs), including in situ carcinomas and invasive carcinomas ≤1 cm, according to the definition given by Hartmann in Cancer (1984;53:681‐4).