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Prediction of Drug Treatment Effective in Narcolepsy Based on Digital Computer Analyzed EEG

INTHODUCTION In 1880 Gelineau (1) first descr-ibed a disease characterized by recurring sleep episodes during the daytime, sudden loss of muscle tone without clouding of consciousness (cataplectic attacks), brief episodes of inability to perform voluntary movements (sleep paralysis) and hypnagogic hallucinations. In the last three decades various EEG investigators have tried to solve the question of whether or not narcolepsy is an epileptic disease. Cohn and Cruvant (2), Roth (3), Stoupel (4), Vizioli and Giancotti (5), Bjerk and Hornisher (6) and Lugaresi (7) have described abnormalities in the EEGs of narcoleptic patients, indicating that the disease might be an "epileptic equivalent," while the majority of the investigators, including Blake et al. (8), Dynes and Finley (9), Gibbs and Gibbs (10,11), Aird et al. (12), Heyck and Hess (13), Daly and Yoss (14), Gastaut and Roth (15) and Roth (16), have reported electroencephalograms within normal limits. There is also evidence of a disturbed all-night sleep process in narcolepsy, i.e., narcoleptic patients have an insufficient n umber of deep slow waves sleep stages, numerous episodes of waking, and sometimes an excess of REM sleep (5, 17, 18), Rechtschaffen et al. (18), Roth et al. (19), Vincent et al. (20) and Hishikawa et al. (21) also reported a characteristic onset of sleep with REM activity when cataplexy was present. Thus, till now the main goals in the treatment of such cases have been improvement of the disturbance in the sleep-awake cycle, maintenance of wakefulness during daytime, insurance of sound sleep at night, and relief from cataplectic attacks which