{'fraction_non_alphanumeric': 0.01327433628318584, 'fraction_numerical': 0.014749262536873156, 'mean_word_length': 4.925764192139738, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
[Dilatation of the sinusoids in liver tissue caused by oral contraceptives. Electron microscopy studies in 14 cases of surgical liver excision].

Various liver changes due to taking oral contraceptives have been described one of them is the dilation of sinusoids. About 40% of patients who underwent liver biopsy had this condition. Whether it is a benevolent reversible phenomenon or it could lead to severe peliosis hepatis is not clear. In a previous study by the authors 5 patients had liver biopsies because of hepatomegaly and slightly positive liver function tests. Both sinusoid ectasia and hepatomegaly became reversed after the discontinuation of contraceptives. In another study cholecystectomy was performed in 21-40 year old women with complaints of gallstones with contraceptive use of 6 months to 12 years. 37 biopsies were taken and examined by electron microscope. 14 showed dilatation of the liver sinusoids. As controls 10 liver tissues of patients who underwent liver resection because of tumors were studied. 8 of these had dilatation of sinusoids and in 2 cases peliosis hepatis was observable. It is possible that the elements of the cytoskeleton are damaged by contraceptives and perhaps changes also occur in the shape and motility of liver cells which can promote the dilation of sinusoids. More studies are needed to verify this.