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Efficient fluorescence resonant energy transfer between ZnO nanoparticles and fluorescein dye in liquid medium for cell imaging and cancer therapy

This paper reports the Fluorescence Resonant Energy Transfer (FRET) mechanism observed in fluorescein dye doped ZnO nano composite which is due to the electron transfer between the acceptor and the donor resulting in the fluorescence quenching of the donor. The Fluorescein Isothiocynate (FITC) encapsulated multifunctional ZnO nanocomposite can be used as smart nanostructures for cell imaging and cancer therapy. During FRET the energy transfer between the donor and acceptor takes place non-radioactively. This result is of great use in the quantitative analysis of molecular dynamics in biophysics and microbiology. We have observed FRET efficiency as high as 76% in the studied composite by varying the doping level of ZnO nanoparticles with Fluorescein dye. We have confirmed the potential of this composite for cancer treatment and cell imaging. These results are also reported.This paper reports the Fluorescence Resonant Energy Transfer (FRET) mechanism observed in fluorescein dye doped ZnO nano composite which is due to the electron transfer between the acceptor and the donor resulting in the fluorescence quenching of the donor. The Fluorescein Isothiocynate (FITC) encapsulated multifunctional ZnO nanocomposite can be used as smart nanostructures for cell imaging and cancer therapy. During FRET the energy transfer between the donor and acceptor takes place non-radioactively. This result is of great use in the quantitative analysis of molecular dynamics in biophysics and microbiology. We have observed FRET efficiency as high as 76% in the studied composite by varying the doping level of ZnO nanoparticles with Fluorescein dye. We have confirmed the potential of this composite for cancer treatment and cell imaging. These results are also reported.