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Nonlinear mixed effects evaluation of Hamilton Depression Rating Score following combination treatment of presynaptic- and postsynaptic glutamate receptor inhibitors in bipolar depression patients

Presynapticand postsynaptic glutamatergic modulation is associated with anti-depressant activity that takes several weeks to reach a maximal full effect [1]. Limiting mood elevating effects after single drug administration may be the result of compensatory synaptic processes [2, 3]. Therefore, using augmentation treatment with agents having presynapticand postsynaptic effects on the glutamatergic system (lamotrigine and memantine, respectively), this study aims to evaluate the effect of augmentation therapy on the rate of change in mood elevation in patients with bipolar depression.