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Rubia cordifolia extract inhibits cell proliferation in A‐431 cells

The antiproliferative property of Rubia cordifolia (Rubiaceae) extract has been studied on two different cell types, A‐431 cells (epidermal carcinomoid cells) and 3T3 fibroblast cells. It was observed that a fraction of Rubia cordifolia significantly inhibited the incorporation of [3H]‐thymidine, induced by fetal bovine serum, in a dose‐dependent manner. It also inhibited the PMA (phorbol 12‐myristate 13‐acetate) induced expression of c‐fos genes in A‐431 cells. It appears that inhibition of DNA synthesis underlies the mechanism for its antiproliferative properties. © 1998 John Wiley & Sons, Ltd.