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Chemical Composition and In vivo Anti-inflammatory Activity of Bursera morelensis Ramírez Essential Oil

Abstract Bursera morelensis Ramírez is an endemic tree from Mexico that posses a relatively higher quantity of essential oil respect to others species of the same genus. This work was focused on the determination of the chemical composition of Bursera morelensis Ramírez essential oil and its anti-inflammatory activity when extracted by steam distillation from aerial parts. GC and GC-MS analyses displayed the presence of at least 17 components that constitute the essential oil including α-phellandrene, β-phellandrene, α-pinene, caryophyllene and p-cymene, as major components. Anti-inflammatory activity was evaluated by means of the carrageenin induced rat paw edema model, displaying a positive anti-inflammatory behavior comparable to Dexamethasone as reference standard. Results justify the use of B. morelensis Ramírez as antiinflamatory in the traditional medicine, nevertheless, further studies are required to best understand its mechanism of action.