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Pilot Study Comparing Adrenergic and Substrate Dependent Oxygen Consumption Rates Between Malignant Hyperthermia Susceptible (MHS) and Malignant Hyperthermia Non‐Susceptible (MHN) Immortalized Human B‐Lymphocytes

Heat or exercise have been implicated as potential initiators of the hypermetabolic cascade within MHS individuals. A significant amount of the MHS diagnosed population do NOT express known pathogenic mutations. Greater screening for MH susceptibility is required. Altered 3’ 5’ cyclic adenosine monophosphate (cAMP) second messenger activity and altered metabolism have correlated with the MHS genotype.