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A-112 Cognitive Reliability and Time to Failure Rate Theory and Genetics


 Objective: In this study, we utilized the cognitive reliability intact the failure theory toward an understanding of the impact of genetics and more specifically APOE-4 on cognitive decline. This method allows for the identification of the threshold as well as the decline rate in groups with different levels of education.
 Method: Data was obtained from the National Alzheimer’s coordination center(NACC). Following Brickell et al, 2020 we focused on the Trail Making Test part B (number of seconds to complete the task) and semantic fluency (animals) tests.
 Results: The study shows higher performance on the TMT B among those without the E4 allele emerging already at the age of 65. The decline rate however remains identical across the 3 groups. On the Semantic Fluency, Taskwe compared high school and college-educated subjects. Those without copies of the E4 allele exhibit stable functioning until about the age of 75 and then show a rapid exponential decline. Those with one copy exhibit an earlier threshold at about the age of 55. Those with a college education have a higher asymptote and show a decline before the age of 45 With the rate of decline has a linear characteristic.
 Conclusion(s): The present study demonstrates the utility of the reliability intent of failure theory for the study of cognitive decline across the lifespan. They show that the distinction between threshold decline rates could serve as an important factor in examining the impact of genetics.
