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Olanzapine induced neutropenia: Rechallenging with olanzapine combined with lithium

Olanzapine is an atypical antipsychotic medication and a very effective treatment for schizophrenia. However, it is associated with third highest incidence of neutropenia among all antipsychotics, and this may limit its use. We present a case of a schizophrenic female who was successfully treated with olanzapine and lithium to enhance white blood cells after a history of neutropenia caused by olanzapine treatment. We briefly discuss the use of lithium in patients who were rechallenged with antipsychotic medications. This case study supports the use of lithium for olanzapine-induced neutropenia as a successful and safe strategy.