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Glyceryl-ether Monooxygenase [EC 1.14.16.5] A Mixed Function Oxidase Requiring Oxygen and a Tetrahydropterin Cofactor

Glyceryl-ether mono-oxygenase is a microsomal enzyme present in mammalian tissues. It is improtant in ether-lipid metabolism and ether-lipids may form up to 15% of lipids in tissues. The enzyme isolated from rat livers shows strict requirement for oxygen and a 2-amino-5,6,7,8tetrahydropteridin-4-one in order to hydroxylate the a-CHz of the aliphatic acid side-chain of 1alkyl glyceryl ethers (13 ).