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Comparative study of ~(13)C octanoic acid breath test and gastric emptying ultrasonography for gastric emptying of meal in diabetic patients

Objective: The 13C octanoic acid breath test (OBT) has been proposed as a reliable noninvasive test to measure gastric emptying. OBT has been compared with scintigraphy; however, there are no data comparing it with gastric emptying ultrasonography (GEU).The aim of this study was to correlate gastric emptying of a solid meal, with OBT and GEU evaluated in diabetic and healthy group. Methods: A total of 71 patients with diabetes and 30 normal subjects ingested a standard test meal with 100 mg of 13C octanoic acid. Breath samples for 13CO2 analysis were collected. GEU was also performed. Lag time (tlag) and half gastric emptying time GET1/2 were calculated for OBT. Data were analyzed by the Student's t test for paired data, correlation coefficient, and regression line. Results: The results show a statistically significant longer tlag and GET1/2 for OBT in diabetes. A significant correlation was computed between OBT and GEU. Conclusion: Results show that both techniques give data in good correlation. Because OBT is less operator-dependent, it may be more useful in clinic.