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Zinc and the Skin

The word zinc can be traced as far back as 1525, when Paracelsus is credited as having discussed "zinken."1 Among the essential trace metals, zinc has further claim to historical precedence. The zinc protein carbonic anhydrase was the first metalloenzyme to be identified.2 Many other essential enzymes and most alkaline phosphatases and alcohol dehydrogenases have since been identified as zinc proteins.J, 4