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Estrone‐3‐Sulfate is a substrate to verify functionality of uptake transporters in primary hepatocytes

Primary mammalian hepatocytes are used for several in vitro applications like testing of drug metabolism, toxicity and transporter assays. However, little is known about species specific differences or similarities in the activity of uptake and efflux transporter. Therefore, we started a species specific characterization and comparison of uptake transporters functionalities in relevant species used for drug testing. Here, we report the uptake of estrone‐3‐sulfate (E3S) in primary hepatocyte cultures of human, rat and monkey.