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Extracellular acidosis contracts coronary but neither renal nor mesenteric artery via modulation of H+,K+‐ATPase, voltage‐gated K+ channels and L‐type Ca2+ channels

What is the central question of this study? We asked whether there are any differences in responses to extracellular acidosis among arteries of different origin and whether K+ channels, Ca2+ channels and H+,K+‐ATPase are involved in extracellular acidosis‐induced coronary myogenic responses. What is the main finding and its importance? This report is the first to demonstrate that extracellular acidosis alkalinizes the cytosol of arterial smooth muscle cells freshly isolated from rat coronary artery and contracts the artery exclusively and to suggest that modulation of voltage‐gated K+ channels, voltage‐gated Ca2+ channels and H+,K+‐ATPase are involved in the contraction.