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CD4+ T cell cytokine production is influenced by jagged 1

Notch is a promiscuous system consisting of four receptors and five ligands that is important for providing signals to direct cell differentiation in developing organisms. It has been shown that the Notch system also plays a role in T cell education. Recently, several labs have demonstrated that Notch signals also play a role in the activation of T cells during immune responses. While the Notch ligand Dll4 is upregulated on dendritic cells (DC) via a MyD88 dependent pathway, the ligand Jagged 1 is constitutively expressed on DC. To determine the role of jagged 1 in directing T cell immune responses, we used a specific polyclonal antibody to block this ligand during both a primary and secondary response to S. Mansonii eggs. The data indicate altered levels of the Th2 cytokines IL‐4, IL‐5 and IL‐13 as well as IL‐10 regardless of if the response was a primary or secondary in nature. Further studies where CD4+ T cells were stimulated with anti CD3/CD28 in the presence of recombinant jagged 1 demonstrate that this molecule alters the level of Th2 cytokines.