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Chernogubov's syndrome: a translation of the first modern case report of the Ehlers-Danlos syndrome.

The heritable disorder of connective tissue, now termed Ehlers--Danlos syndrome, was described by Chernogubov, a Russian dermatologist, in 1892. His graphic description of the first modern case with multisystemic features is presented in English translation. Chernogubov attributed the development of this disorder to a generalized defect in the embryological formation of connective tissue fibers. Chernogubov's observations were recognized by his colleagues as providing new insights in explaining an interesting and puzzling case. In the literature of the Soviet Union this syndrome is known as Chernogubov's syndrome. This work is justifiably recognized as a seminal publication in rheumatology.