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Microarray analysis of the PVN of spontaneously hypertensive wistar rats (SHR)

The paraventricular nucleus (PVN) of the hypothalamus is a key autonomic regulation area in the brain known to influence sympathetic nerve activity. Identified neurons project from the PVN to the spinal cord and can modulate cardiac function (Coote JH 1995). The PVN has been linked to cardiovascular diseases such as hypertension, where an elevation in sympathetic nerve activity is observed (Guyenet PG 2006 and Zhang K et al. 2002). For example, the activity of ‘spinally projecting’ PVN neurons is altered in models of heart failure (Patel KP 2000) and lesioning of the PVN prevents the development of spontaneous hypertension in SHRs (Takeda K et al. 1991).