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Novel Insights Into the Genetics of Intracerebral Hemorrhage

Isolated observations suggest a role for genetic risk factors in intracerebral hemorrhage (ICH). However, no systematic evaluation on the role of DNA variation in ICH has been attempted to date. We performed a large-scale genetic association study of 2189 ICH cases and 4041 controls. We included 1104 ICH cases attributable to cerebral amyloid angiopathy (CAA-ICH) and 1085 hypertensive ICH cases (H-ICH). Recently developed methods were used to determine heritability from unrelated ICH cases and controls. We also analyzed clinical ICH phenotypes: …