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Case reports of patients with treatment-resistant schizophrenia and related psychotic disorders intolerant to clozapine responding to high doses of quetiapine

Treatment-resistant schizophrenia and related psychotic disorders remain a major therapeutic challenge. Clozapine has undoubtedly been the gold standard treatment for this patient group. However, a significant proportion of patients develop intolerance to clozapine. There is limited available evidence to support the use of alternative treatment strategies. 
 
In this case report we present two diagnostically different cases, where stabilization on clozapine was followed by discontinuation due to the development of neutropenia. These cases were subsequently managed with high doses of quetiapine, which produced a satisfactory clinical response.