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INFLUENCE OF EXPRESSION OF THE NEONATAL FC-RECEPTOR (FCRN) ON THE SENSITIVITY OF THE CELLS TO NON-PATHOGENIC HUMAN ENTEROVIRUSES

In this work, the influence of the expression levels of the neonatal Fc receptor (FcRn) on the sensitivity of the human transformed and tumor cells to 15 non-pathogenic strains of human enteroviruses was shown. The Complete inactivation of the neonatal fc receptor gene FCGRT in cells led to loss of the sensitivity to Echoviruses 1, 6, 7, 11, 12, 25, 30, enterovirus 75.