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ANALYSIS OF ANTIOXIDANT PROTECTION INDICATORS FROM THE POSITION OF AGE CHANGES IN CHRONIC PANCREATITIS PATIENTS

Introduction. The identification and assessment of all external and internal factors affecting the development of the chronic pancreatitis (CP) is one of the most important conditions for the personalized selection of its adequate therapy. The authors analyze the indicators of lipid peroxidation (LPO), endogenous intoxication (EI) and the antioxidant defense system (AODS) in CP patients of different ages. The objective: to assess the indicators of LPO, EI and the AOS system in CP in different year classes. Materials and methods. 247 CP patients were examined; they were divided into 3 groups depending on age. The control group consisted of 30 apparently healthy persons of different ages without clinical signs of CP. LPO was assessed by the level of malonic aldehyde (MA) according to the method of V. B. Gavrilov et al. AODS was determined by the level of SOD; ceruleoplasmin (CP) was determined in blood serum (according to Ravin); free glutathione (SH-groups) was determined by Boyer method with sodium p-mercurbenzoate; catalase according to the level of decomposition of hydrogen peroxide and determination of the ratio of catalase number to the number of erythrocytes. Statistical processing of the results were carried out with the use of standard software packages Microsoft Excel and Statistica 6.0. The results were evaluated according to Student's t criteria. Results: It was revealed that LPO activation in terms of MDA, MM and EI response significantly increases in the middle age category (p <0.05) and in CP patients over 66 years old (p <0.001). Simultaneously, weakening of enzymatic (by levels of SOD, catalase) and non-enzymatic (according to the state of free glutathione, retinol and tocopherol) composition of the AODS (p <0.05) took place. It was established that with the increase of biological age depletion of host defenses followed by signs of oxidative stress and endotoxemia took place. It was proved by SOD (p <0.05) and (p<0.001) and catalase (p <0.001) decrease in middle-aged and elderly CP patients. The study of the vitamin balance showed a decrease in retinol and tocopherol levels in older age CP patients, in the group of elderly patients their levels were below normal (p <0.001). Conclusions. The results obtained will make it possible to create a scheme of differentiated approach to clinical examination of CP patients depending on their age, and predict of polyinutrient disorders accurately and timely.All human studies were conducted in compliance with the rules of the Helsinki Declaration of the World Medical Association "Ethical principles of medical research with human participation as an object of study". Informed consent was obtained from all participants.