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Progressive melanosis of the skin

SIR, The case reported in detail by Dr Levene {British Journal of Dermatology (1979) loi, 197) may be identical with one or more of those described by Darier in 1925 and referred to in his Precis (Darier, 1928) as mesenchymatous malignant melanoma or melanosarcoma or progressive melanosis. Darier comments on the similarity to the melanosis of white horses. The case I reported (Bettley, 1938) more closely resembles those subsequently described by Ito. In my paper I included a brief account of a calf affected by benign melanosis and accepted Darier's suggestion that the human cases have much in common with those of horses and cattle. My case showed no evidence of dissemination at the time, but was lost to follow-up.