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Interferon System in Primary Acute Lymphocytic Leukemia Cells With or Without Deletions of the <w-/P-Interferon Genes

Various aspects of the intetferon (IFN) system were studied in malignant cells from 37 unselected patients with acute lymphocytic leukemia (ALL). It was found that leukemic cells from two of 37 patients had a complete loss of w and fi-IFN genes, whereas cells from four of 37 had lost one of the u / ~ I F N alleles. In 25 cases, viable cells were also available for functional studies. Cell clones with loss of one of the a-/p-IFN alleles produced low amounts of IFN after virus induction in vitro. Some clones with an apparently normal set of IFN genes were unable to produce detectable amounts of IFN. All clones studied were found to carry high-affinity IY-IFN receptors. In clones carrying deletions of IFN genes, the cells were sensitive to IFN in vitro as measured by a-IFNinduced enhancement of 2‘,5‘-oligoadenylate synthetase