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Anti-tumor necrosis factor alpha therapy of rheumatoid arthritis. Mechanism of action.

The use of anti-TNF-alpha antibodies has led to considerable new insights into their mechanism of action, and by inference into the pathogenesis of disease. The work has shown that cytokines are very useful targets for therapy. A deeper account of recent findings in this field is found in (Feldmann et al., 1996; Feldmann et al., 1997; Maini, 1996; Maini et al., 1995). IN VITRO BIOLOGY OF ANTI-TNF-alpha (cA2) [...]