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Plasma and Cerebrospinal Fluid Progesterone Concentrations in Pregnant and Nonpregnant Women

Pregnancy is associated with a wider dermatomal spread of local anesthetics after epidural and spinal anesthesia. This phenomenon also exists in the immediate postpartum period. The mechanism of this observation is unresolved. However, an increase in progesterone concentration in pregnancy has been implicated as one of the factors. Although plasma progesterone concentrations in humans have been well-documented, the cerebrospinal fluid (CSF) progesterone levels, which may also be important in this regard, have not been determined. Therefore, this study was undertaken to measure plasma and CSF progesterone in the nonpregnant, term parturient and in the immediate postpartum patient and also to determine the relationship between the CSF progesterone concentration and the intrathecal spread of lidocaine used for spinal anesthesia. The plasma progesterone concentrations in 12 nonpregnant, 21 term and eight postpartum patients were 2.3 ± 61 (SEM) ng/ml, 122 ± 8 ng/ml and 16 ± 2.2 ng/ml, respectively. The CSF progesterone concentrations in term parturients (3 ± 0.28 (SEM) ng/ml) and postpartum patients (1.03 ± 0.16 ng/ml) were eight and three times greater than that of nonpregnant women (0.39 ± 0.01 ng/ml). Significantly less lidocaine was needed (P < 0.05) for comparable segmental levels of spinal anesthesia in term and postpartum patients than in nonpregnant individuals. These data suggest that high CSF, plasma progesterone concentrations, or both may augment the anesthetic spread of lidocaine.