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Effect of ozone therapy on the emotional state of a patient after the novel coronavirus infection

Purpose of the study. To assess the impact of systemic ozone therapy on the emotional state of patients after the novel coronavirus infection in the early recovery period. Materials and methods. A randomized controlled clinical trial, including 39 patients aged 29 to 78 years with a confirmed diagnosis of bilateral polysegmental viral pneumonia associated with SARS-CoV-2 coronavirus (J12.8), was conducted. The patients were divided into 2 statistically comparable groups. In the first group (N=19), the patients received a standard complex of rehabilitation treatment: exercise therapy, chest massage, and physiotherapy procedures (low-frequency magnetic therapy and drug electrophoresis in the projection of the lung fields), while the patients in the second group received daily intravenous infusions of ozonated saline solution with an output ozone concentration of 2.0 mg/l in addition to the basic complex rehabilitation. In order to assess the impact of systemic ozone therapy on the emotional state of the patients who underwent COVID-19, we analyzed the dynamics of complaints, changes in the quality of life of the patient based on the EQ-5D-3L questionnaire, as well as the severity of anxiety and depression according to the results of the HADS (Hospital Anxiety and Depression Scale) on the 1st and 10th days of the rehabilitation treatment. Results. In all patients, positive dynamics was noted against the background of rehabilitation measures in relation to complaints, the severity of anxiety and depression, as well as the quality of life. At the same time, the analysis of various indicators revealed greater efficiency in the prescription of a comprehensive program, including systemic ozone therapy. Conclusions. The use of ozone therapy in the complex rehabilitation of patients who have undergone COVID-19 has shown its efficiency and safety. Further study in higher number of patients is required to determine indications and criteria for its use.