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C6 Peptides from Borrelia Burgdorferi Sensu Stricto, Borrelia Afzelii and Borrelia Garinii as Antigens for Serological Diagnosis of Lyme Borreliosis

ABSTRACT Four different peptide ELISA tests were developed for the first time in Bulgaria based on IR6 regions of two B. burgdorferi sensu stricto strains, one B. afzelii and one B. garinii strain. Serum samples from patients with various manifestations of Lyme borreliosis were tested in order to reveal the applicability of such antigens. Test specificity was tested by reactivity with sera from other than Lyme borreliosis diseases, all of them already well-known to give false-positive results. This study showed that C6 peptides can be used successfully for diagnosis, since up to 80% of the patients with early Lyme borreliosis and neuroborreliosis and all patients with Lyme arthritis could be diagnosed by the peptide ELISA tests. The data obtained revealed higher reactivity of C6 from B. burgdorferi sensu stricto in comparison with C6 peptides from B. garinii and B. afzelii.