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Characterisation of mechanisms of relaxation induced by omega‐3 polyunsaturated fatty acids (n‐3 PUFA) EPA and DHA in rat aorta and mesenteric arteries: A novel a role for IKCa and TRPV4 channels in DHA mediated relaxation

The omega‐3 polyunsaturated fatty acids (n‐3 PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) known as “fish oils” are associated with improved cardiovascular health. Their ability to relax blood vessels and reduce blood pressure contribute to these effects. Numerous studies investige the mechanisms of n‐3 PUFA mediated relaxation and various vasodilator mechanisms are implicated, including the NOS and COX pathways, and a direct effect on BKCa channels. Few studies fully characterised the dilator response and focus on either DHA or EPA in a single artery. We conducted a full characterisation of the various potential vasodilator mechanisms for both fish oils in a large muscular artery (aorta) and a resistance artery (mesenteric).