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Analysis of time sequence of glucocorticoid action on granulomatous inflammation.

Time course of the effects of a single local injection of glucocorticoid on synthesis of collagen, non-collagen protein and deoxyribonucleic acid (DNA), and on vascular permeability of pre-formed carrageenin granuloma in the rat has been investigated. Maximum inhibitions for the synthetic activity of collagen and non-collagen protein were attained at 4 hr after the administration of a single dose (3 mg/kg) of hydrocortisone acetate. The synthetic activity of collagen had recovered quickly to the control level at around 18 hr after the injection of the steroid, while non-collagen protein showed a recovery reaching the control level at 32 hr. The inhibitory effect of the steroid on the synthetic activity of DNA was greater than those on proteins and a significant inhibition was still noted at 32 hr (34.7% inhibition). Vascular permeability measured with the aid of radioiodinated human serum albumin was also inhibited markedly by the steroid treatment and preserved the level of 48% inhibition continuously from 8 hr upto the end of the experimental period. Possible differences in the mechanism of action of anti-inflammatory steroid between a single acute and repeated chronic treatments are discussed.