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Liver Function Status of Hypertensive and Normotensive Rats Administered Persea americana Mill. (Avocado) Seeds

The effects of aqueous seed extract of Persea americana var. fuerte (avocado) on body weight, blood pressure, serum levels of total protein, albumin, alkaline phosphatase, alanine and aspartate aminotransferases were investigated. Thirty albino rats were divided into six groups of 5 rats each; group 1 (normal control), group 2 (hypertensive control), group 3 (hypertensive+200 mg/kg), group 4 (hypertensive+500 mg/kg), group 5 (hypertensive+700 mg/kg) and group 6 (normal+200 mg/kg). Except for group 1 and 6, which received 100% growers mash, all other groups received 92% growers mash and 8% NaCl as their daily meal for 4 weeks. Results showed significantly (P 0.05) differences in protein, albumin, alanine and aspartate aminotransferases of normal and hypertensive rats administered the different doses of the aqueous seed extract. Alkaline phosphatase activity were significantly reduced in normal rats administered the aqueous seed extract. This work justifies the use of avocado seeds in the treatment of hypertension and demonstrates its antihepatotoxic effect.