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Preliminary Study of Pulsed-Electromagnetic Fields Effects on Endothelial (HUVEC) Cell Secretions—Modulation of the Thrombo-Hemorrhagic Balance

We investigated the role of low-amplitude magnetic pulse with low repetition frequency superimposed on the environmental electromagnetic field (EMF) on the secretion of anti-aggregant (Prostacyclin or PGI2) and pro-aggregant (Thromboxane A2) agents in endothelial cells of the human umbilical cord vein (HUVEC). We established that magnetic pulse exposure modulates both PGI2 and TXA2. These modulations depend on the frequency, width of the pulse, and intensity of the magnetic field. Moreover, we corroborated previous results obtained with an endothelial cell line (EaHy-926), concerning the increased thrombo-embolic risk for the 1 Hz frequency.