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Temporary changes in acid phosphatase activity in the organs of mice treated with AET or MEA prior to 60Co gamma-irradiation.

Different patterns of temporary changes were observed in the acid phosphatase/E.C. 3.1.3.2./activity in the spleen, liver, and kidneys expressed in nkat per 1 mg of protein, 1 g of fresh tissue, and per whole organ weight in mice exposed to 60Co gamma-rays only and those irradiated after AET (2-aminoethylisothiouronium Br.HBr) or MEA (cysteamine HCl) treatment. The extent and timing of the alterations in enzyme activity was dependent on the particular organ chosen and the thiol agent applied. AET and MEA administered before irradiation modified the effects of exposure of mice to gamma-rays on the acid phosphatase activity in the organs studied.