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Repair of potentially lethal lesions in x-irradiated, density-inhibited Chinese hamster cells: metabolic effects and hypoxia.

Plateau phase Chinese hamster cells (HA-1), growing in monolayers, form a convenient system for studying the repair of potentially lethal damage. Cells are irradiated under conditions of density inhibition, and the interval between irradiation and explant (to assay survival) is varied. Repair is evidenced by higher survival of those cells maintained in plateau. This increase in survival can be expressed as a slope-modifying factor. The magnitude of the slope-modifying factor is determined by the cells' post-irradiation environment. Cells overlaid with Hanks' BSS in the interval between irradiation and explant showed a maximum slope-modifying factor (∼1.3), cells in serum free or "conditioned" medium a somewhat lower value, while minimum repair was seen if the cells were in fresh medium supplemented with fetal bovine serum. Hypoxia does not seem to affect the magnitude of repair of potential lethal damage if the comparison of survival increase is made at similar survival (rather than dose) levels. Cells in...