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Nondialyzable urinary hydroxyproline as an index of bone collagen formation.

ABSTRACT Total and nondialyzable urinary hydroxyproline was measured in normal subjects and patients with metabolic bone disease. Normal adult urinary nondialyzable hydroxyproline was approximately 10% of the total urinary excretion of this imino acid. Dietary deprivation of hydroxyproline resulted in a decreased dialyzable hydroxyprolinuria, whereas the excretion of the nondialyzable form remained constant. Corrective surgery in 7 hyperparathyroid subjects was followed by an increased urinary excretion of nondialyzable hydroxyproline, and decreased amounts of the dialyzable form. The infusion of calcium into an acromegalic, hyperparathyroid subject was associated with a decrease in dialyzable hydroxyproline excretion, without alteration in the excretion of the nondialyzable component. The administration of growth hormone to hypopituitary dwarfs and normal subjects caused proportional increases in dialyzable and nondialyzable hydroxyproline excretion. Proportional decreases in dialyzable and nondialyzable...