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BENEFICIAL EFFECT OF VITAMIN D SUPPLEMENTATION ON WEIGHT AND BMI OF MICE TAKING HIGH-FAT DIET

: Objective: Obesity is a serious health issue that is rising worldwide. Underdeveloped and developed countries both are becoming the culprits of this pandemic. Decreased levels of vitamin D and obesity are correlated. This study was planned to see whether vitamin D supplementation has any effect on weight and body mass index (BMI) of mice taking the high-fat diet. Methods: This was a randomized control trial, conducted at the Physiology Department of Akhtar Saeed Medical and Dental College, Lahore from October 2017 to December 2017. Ninety (90) male mice were randomly divided into 3 groups. Each group had 30 mice. The total duration of the study was 6 weeks. Group A was the normal diet control group, Group B was the high-fat diet control group, Group C was high-fat diet and vitamin D taking test group. The weight of every mouse was recorded twice a week for 6 weeks by the electronic weighing machine. Initial and final nasoanal length of every mouse was taken and initial and final BMI was calculated. The difference in the nasoanal length and BMI was calculated and data was analyzed using SPSS version 20. Results: Mean weight of group B mice increased significantly as compared to group A mice(p=0.005). Mean weight of group C mice reduced significantly as compared to group B mice(p=0.028). Mean weight of group A and C mice was not significantly different from each other (p=0.822).Mean BMI of group C mice reduced significantly as compared to group B mice (p=0.002). BMI of group A and B mice was not significantly different from each other (p=0.330). Difference of BMI between group C and A was also statistically insignificant (p=0.111). Conclusion: Vitamin D prevents weight gain and increase in BMI of mice taking high fat diet.