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Female sex of older patients is an independent risk factor for red blood cell alloimmunization after transfusion

More women than men are encountered with red blood cell (RBC) antibodies. It is not clear whether this difference is explained by more immunizing events in women or by a different acting immune system. To assess whether there is a difference in the posttransfusion RBC alloimmunization rate between women and men, a study on RBC alloimmunization during a 5‐year period was conducted in patients with at least one antibody follow‐up more than 14 days after transfusion.