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HLA AND NON‐INSULIN DEPENDENT DIABETES IN FIJI INDIANS

HLA frequency distributions in Fiji Indians with non‐insulin dependent diabetes were compared with those in control subjects with confirmed two‐hour plasma glucose levels less than 7.8 mmol/L. Antigen frequencies at HLA‐A and HLA‐DR loci were similar in patients and controls. At HLA‐B, there was a significant increase in Bw61 (Bw40.2) in diabetics, with a relative risk for this antigen of 4.8. Since a similar finding has been reported previously in South African Indians with insulin‐dependent diabetes, it is possible that we have defined yet another genetically‐distinct form of diabetes, especially prevalent in Indians. Alternatively, definition of new HLA alleles such as Bw61, a new subdivision of an established antigen, may reveal HLA associations with non‐insulin dependent diabetes in European Caucasians also.