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High Sodium Diet – Role in Renal Sympathodepression

Afferent renal nerve pathways are likely involved in the development of salt sensitive hypertension. We recently reported that intrarenal NaCl elicited a long‐lasting sympatho‐depression via a neuro‐humoral TRPV1 dependent and tachykinin mediated renal afferent nerve pathway. We now wanted to test the hypothesis that high sodium intake impairs this afferent sympatho‐depressory mechanism.