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Biochemically-defined differentiation markers on human early haemopoietic (K562) cells.

Both haemin, contrary to a previous report, and the tumor promoter TPA induce pronounced changes in surface protein patterns of human erythroleukaemic (K562) cells. Three major surface proteins are down-regulated by both inducers. These are not merely growth-related proteins and therefore represent candidate markers for an early stage of haemopoietic differentiation.