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EP14.37: Cerebroplacental ratio for the prediction of placental vascular malperfusion in normally grown fetuses

Objectives: A number of placenta abnormalities may cause fetal growth restriction, which is assumed to be due to uteroplacental insufficiency. We discussed the correlation between 2D ultrasound images and pathological findings of the placenta with early-onset severe fetal growth restriction (FGR). Methods: This was a retrospective study performed at a single tertiary perinatal centre. Two obstetrical specialists and one pathologist reviewed medical records. Severe FGR was defined as estimated fetal body weight with less than 3rd percentile based on the guideline by the Japanese Society of Ultrasonics in Medi. Results: In some cases with early-onset severe FGR, huge fluid-like images were observed among placental villi. Their pathological findings were reported to be intervillous fibrin deposition or villitis of unknown etiology in 75%. Conclusions: The huge fluid-like area in the placenta could be linked to histological findings of intervillous fibrin deposition or villitis of unknown etiology and may cause early-onset severe FGR.