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Transformation of Cells from the Normal Human Amnion into Established Strains*

Previous communications from this laboratory have reported the cultivation and poliovirus in fection of cells from the normal human amnion (11), the cytological changes associated with polio virus infection (3), and the continuous cultivation of a strain of cells (5). The present paper describes the transformation of cells from four normal human amnions into seven established, rapidly growing strains. These observations were made over a period of 8-14 months.