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Crystal‐storing histiocytosis and immunocytoma associated with multifocal fibrosclerosis

Crystal‐storing histiocytosis is a rare disorder described in patients with lymphoproliferative diseases, mainly in cases of multiple myeloma but also in lymphoplasmacytic lymphoma (immunocytoma). Most cases involve one single organ which, in the majority, is related directly to the presence of tumour. We describe a 44‐year‐old man with a clinical picture of multifocal fibrosclerosis (with mesenteric panniculitis, peritoneal, mediastinal and orbital fibrosis) in which the autopsy showed a systemic infiltrate of crystal‐storing histiocytes and functional alteration of the organs involved, associated with IgG‐kappa type immunocytoma.