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Late diagnosis of Neural Tube Defects: About two uncommon cases

Background: Neural tube defects are pathologies of the central nervous system occurring between the 23rd and 27th day of embryonic life. Classified into two groups: cephalic pole anomaly (anencephaly) and spinal pole anomaly (spina bifida), these are uncommon anomalies representing one case per 1000 births, often resulting in therapeutic termination of pregnancy. The etiopathogenesis is not yet known but an interaction of genetic, environmental and drug factors is implicated. Folic acid supplementation is a means of prevention. Ultrasound is an essential and increasingly effective means of antenatal screening. Our objective is to report two uncommon cases of neural tube closure anomalies diagnosed at birth due to unmonitored pregnancies.