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A new view on development of a Staphylococcus aureus vaccine

When rationally designing a vaccine against a specific pathogen, several categories of microbiologic and immunologic data can offer insight. The identification of the protective antigen is of paramount importance. Another is the nature of the immune response to natural infection, which presumably is protective against recurrent infection caused by the same pathogen. A third category concerns the insight that is sometimes gained from understanding the nature of host defense immunologic defects that predispose to, or increase the severity of, the pathogen in question.