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Changes of content of glutathione and metallothionein at plant cells and invertebrates treated by platinum group metals

The biological activity of the first platinum based cytostatic drug – cisplatin was discovered in 1965. Since then hundreds of platinum(II) and platinum(IV) complexes have been synthesized and evaluated as anticancer agents over past 40 years. Besides that, platinum group metals has been intensively using as a part of catalytic exhaust gas converters. Because of the huge employment of platinum in pharmaceutical and automobile industry, it became necessary to study the influence of platinum group metals on living organisms. Here, we studied the influence of the metals (e.g. cisplatin) on concentration of small peptides and proteins (e. g. glutathione, metallothionein ‐ MT) on invertebrates and plant cell cultures, particularly, earthworms, tobacco BY‐2 cells and duckweed (0 – 160 μM of cisplatin). We found out that content of MT increased about 200 – 500 % with increasing cisplatin concentration at earthworms. MT amounts in the biological samples could be marker of environment pollution.