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Effect of Food Restriction On Risk Assessment

major extrinsic factors contributing to premature death of laboratory animals and humans from degenerative disease and cancer at the end of this century. It is only recently that toxicological scientists have gained a general appreciation that ad libitum (AL) overfeeding of laboratory rodents is one of the most insidious, but significant, uncontrolled variables affecting the current bioassay. AL overfeeding is the single-most significant factor that accounts for much of the continued variability seen in these studies, potentially compromising their useful-