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Relationship between circulating leptin and TNFα in obese and non-obese human subjects in the UK

Obesity constitutes a worldwide health problem and is epidemic in many countries caused by accumulating fat to the point where health is likely to be affected. The objective of this study was to identify relationships between leptin, body fatness, BMI and the pro-inflammatory cytokine TNFa in both obese and healthy control subjects. Ten healthy controls, mean age 23.3 years, mean BMI <22.5 kg/m and seven obese subjects, mean age 27.6 years, mean BMI >34.5 kg/m volunteered for the study. Body fat percentage was obtained with a ‘Harpenden’ skinfold calliper (sturdy metal construction with contoured handgrip) measurement in combination with a body composition programme (Jackson & Pollock 4-Site Equation), the four sites measured were abdomen, suprailiac, triceps and thigh. Body fat percentage was measured using a futrex-5000 body composition analyser, inclusive of measuring ankle girth to measure frame. Plasma concentrations of leptin and the pro-inflammatory cytokine TNFa were measured in all subjects by ELISA (R&D Systems, Ltd, Abingdon, UK). Both plasma TNFa and leptin concentrations were found to be significantly higher in the obese volunteers compared with healthy controls (Table)