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GENETIC POLYMORPHISMS AND PHYSICAL ACTIVITY TO OPTIMIZE WEIGHT MAINTENANCE EFFORTS AND PREVENT CARDIOVASCULAR RISK FACTORS

The development of cardiovascular diseases is due to the interaction of genes with environmental factors. The individual body's response to diet therapy and lifestyle modification also largely depends on genetic factors, in particular the presence of polymorphic variants of the ADRB2 (Gln27Glu), ADRB2 (Agr16Gly), ADRB3 (Trp64Agr), PPARG2 (Pro12Ala) and FABP genes. Despite recommendations for lifestyle modifications, it is especially important for patients with cardiovascular disease to achieve weight loss and maintenance. However, there are no studies comparing the effects of drug therapy and lifestyle modification.