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Demonstration of tumor associated antigen in normal colon and lung

An ion sensitive antigenic site on carcinoembryonic antigen which has been previously demonstrated to be present in non‐entodermally derived tumors and called Tumor Associated Antigen (TAA), has been demonstrated in perchloric acid extracts of normal lung and colon. This antigenic site in normal colon and lung has been shown to be identical to the antigenic site on carcinoembryonic antigen (CEA) by radioimmunoassay and Ouchterlony analysis. This provides further evidence that a common antigenic site exists on CEA as CEA is found only in entodermally derived tumors and is truly tumor specific. This antigenic site in nonentodermally derived tumors and normal tissues is structurally and chemically similar to CEA and further defines the tumor associated antigenic site (TAA).