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High‐resolution mouse kidney perfusion imaging by pseudo‐continuous arterial spin labeling at 11.75T

Quantitative measure of blood flow provides important information regarding renal function, nephropathies and viability of kidney transplantation. Therefore, a method that would allow quantitative and reliable assessment of the renal microvascular perfusion would be very valuable. Arterial spin labeling Magnetic Resonance Imaging has started to be widely used for human studies. For rodents though, despite the increasing number of transgenic mouse models, renal perfusion Magnetic Resonance Imaging has been only sparsely reported. This study investigated the use of FAIR (flow‐sensitive alternating inversion recovery) and pseudo‐continuous arterial spin labeling (pCASL) for mouse renal blood flow measurements.