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Synthesis of isoxazolidines via catalyst-free one-pot three-component cycloaddition of sulfoxonium ylides, nitrosoarenes and alkenes

A general and practical strategy for the construction of various keto-substituted isoxazolidines via one-pot three-component reaction of easily accessible, safer and more stable sulfoxonium ylides, nitrosoarenes and olefins is described. This three-component approach features remarkably much broader substrate scope, good functional group tolerance, good to high yields, operational safety and mild reaction conditions, and this method is also catalyst-free, additive-free and operationally simple.