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THE EFFECTS OF ANTIPYRETICS IN A MOUSE MODEL OF REYE“S SYNDROME

Aspirin has been implicated as an etiologic agent in Reye's syndrome (R.S.) in older children (>4 yrs.). However, in previous experiments, clinical doses of aspirin were unable to initiate any of the features of R.S. when given with Influenza B or varicella virus. We have previously described an animal model of R.S. using young mice exposed to an industrial surfactant and then infected with a mouse adapted Influenza B virus (Lee). We used this model in two age groups of mice, 10 days of age, and weanling mice (4 weeks). Aspirin (ASA), Tylenol (T), or a placebo were given for 3 consecutive days to mice at 50 mg/kg after infecting the animals intranasally with Influenza B virus. ASA and T alone, without surfactant, were also given with Influenza B virus. Survival curves for 10 day olds were statistically similar to virus control with T or ASA. A significant (p=0.01) shift of the early portion survival curve resulted when ASA was given to 10 day old mice which has been preinjected with surfactant and virus, similar results were seen in weanling mice. T had no effect on survival curves. Weanling mice also changed survival curves with ASA and not with T in the early stages of the disease, although, later the survival curves became similar. We conclude that aspirin has the potential of increasing the severity of disease in this R.S. model but by itself without the other factors cannot initiate the disease.