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On the inhibition of 5‐lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo

BACKGROUND AND PURPOSE Leukotrienes (LTs) are pro‐inflammatory mediators produced by 5‐lipoxygenase (5‐LO). Currently available 5‐LO inhibitors either lack efficacy or are toxic and novel approaches are required to establish a successful anti‐LT therapy. Here we provide a detailed evaluation of the effectiveness of the plant‐derived alkaloid tryptanthrin as an inhibitor of LT biosynthesis.