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1037 PROSTAGLANDIN-MEDIATED LYMPHOCYTE SYPPRESSION AFTER PRIMARY EBV INFECTION

Primary Epstein-Barr virus(EBV) infection alters the host's immune system. We examined lymphocyte(PBL) function in 12 young adults for 5 months after infectious mononucleosis(IM) by measuring specific PBL blastogenesis to 7 heat-killed viral antigens. We tested prostaglandin(PG)E2-mediated suppression of these reactions by adding indomethacin(IDH) in vitro. The % enhancement (higher cpm) of antigen + PBL cultures with IDM compared to those without IDM represented the abrogation of PG suppression(A)(100% = no enhancement). The number of antigens (of 7)showing enhancement were averaged(B). Serum content of the PG precursor, arachidonic acid(AA) was measured by gas-liquid chromatography from total lipid extractions (C). We compared these values to those of age-matched normals without IM :PGEg-mediated functional suppression, a minor part of normal im-munoregulation, is markedly increased 5-12 weeks after IM. Total serum AA appears consistent with high PG metabolism. The role of PG in the control of EBV infection merits investigation.