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Enzyme Histochernical Phenotypes in Primary Hepatocellular Carcinomas1

A marked heterogeneity of enzyme histochemical phenotypes was demonstrated in 48 primary hepatocellular carcino mas induced by feeding 2-acetylaminofluorene to rats. All eight possible combinations of three abnormal traits, gain of y-glutamyl transpeptidase activity, loss of adenosine-5'-triphosphatase activity, and loss of glucose-6-phosphatase activity, were represented among the hepatocellular carcinomas. The four combinations in which two or three traits occurred together were seen in 85% of the carcinomas, while those categories with a normal phenotype or containing only single marker changes contained the few remaining neoplasms. As expected, the carcinomas all showed greatly increased and variable [3H]thymidine labeling indices; however, neither the rates of cell replication nor the degrees of differentiation of the carci nomas appeared to correlate in any meaningful way with the patterns of phenotypic diversity. The distribution of histochem ical phenotypes in the carcinomas differs greatly from that reported for enzyme-altered hyperplastic islands induced by carcinogens, but the significance of the difference is not ap parent at the present time.