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Crystalloid Inclusions in Hepatocyte Mitochondria of Dogs Treated with Levamisole

Intramitochondrial crystalloid inclusions were seen in about 10% of the hepatic cells of four dogs treated with levamisole. Three degrees of severity of mitochondrial alteration occurred. Mild changes consisted of condensation of mitochondrial matrix into electron-opaque clumps. The intermediate stage was manifested as well-developed crystalloid inclusions composed of bundles of parallel fibers. Such fibers might be tubular structures. Severe alteration was characterized by a markedly elongated crystalloid inclusion that caused the involved mitochondrion to be greatly enlarged.