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Are Hemodynamic Factors Involved in Cognitive Impairment?

See related article, pp 176–182 

Subjects aged >80 years (the so called old-old subjects) are the fastest growing segment of the population, contributing to the aging of an aging population. In this age group, the prevalence of clinical overt dementia is 30% (when compared with 7% in subjects >65 years of age),1 representing a great burden to family and caregivers and to healthcare costs.

In the current issue of Hypertension , Cooper et al2 reported that elevated carotid-femoral pulse wave velocity (PWV) was associated with higher cerebral white matter hyperintensities (WMH) volume and vascular resistance and higher odds for the presence of subcortical infarcts in a large population of old old subjects. PWV has also been confirmed to be associated with more impaired memory function. …