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[Overcoming difficulties is our goal in 2011].

During the past two years, Investigación Clínica has undergone a substantial reduction in its funding caused by the insufficient budget allotment that the University of Zulia has received from the Venezuelan Government. The progressive increase in the number of articles contained in each issue of the journal caused its weight to exceed the established limits, affecting the distribution costs. Therefore, some adjustments to its structure and distribution are required to maintain its frequency and quality, including reducing the number of papers per issue and sacrificing free shipping to many libraries and health centers in our country and abroad. The "Instructions to Authors" will appear only in the first issue and we will keep the "Index of Authors" in the last issue of the year. Also the publishing of reprints will be limited and only will be sent to authors upon request and shipment pre-payment. Likewise, color pages fees will be canceled to the Publishers, prior to printing. For the above mentioned difficulties, we recommend our regular readers to use the website https://sites.google.com/site/revistainvestigacionesclinicas/, where all articles can be found in PDF format, as they appear in our printed edition. Despite these difficulties, all our collaborators will keep working to maintain the high standards that have characterized this journal for over 50 years, inspired by our founder, Dr. Américo Negrette.