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Adipocyte insulin receptor binding and lipogenesis at term in normal pregnancy

Abstract. Lipogenesis in subcutaneous abdominal adipocytes during late human pregnancy was investigated by studying insulin receptor binding, 3‐O‐methyl‐(14C‐(U))‐glucose flux and incorporation of (14C(U))‐glucose into CO2 (oxidation) and total lipids (lipogenesis) in adipocytes from 18 healthy pregnant women undergoing Caesarean section at term, and 19 non‐pregnant women undergoing gynaecological surgery. The cell diameter and fasting insulin were increased in the pregnant women, compared with controls (P < 0·01 and P < 0·05, respectively). The insulin receptor binding, 3‐O‐methyl‐glucose flux, and basal oxidation were similar in both groups. Basal lipogenesis was higher in adipocytes from pregnant women than from controls (P < 0·05), but the maximally stimulated increment was similar in both groups. Basal and maximally stimulated lipogenesis correlated positively with the cell diameter (P < 0·001 and P < 0·05, respectively). The findings indicate that lipogenesis in subcutaneous abdominal adipocytes from pregnant women is increased due to post‐receptor events and that adipocytes do not contribute to the insulin resistance in late pregnancy.