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[Effects of the graft versus host reaction on the thyroid gland: evidence of correlations between the severity of the immunological conflict and the disease of thyroid activity in the chick embryo].

The allograft of chicken spleen to homologous embryo recipients aged 9 days induces a systemic Graft Versus Host Reaction. In the 8 days after grafting, the recipients show a mesenchymatous goitre. The severity of the immunological conflict, expressed with the spleen index, and the decrease of thyroid activity, detected by follicle number reduction and T4 level fall, are closely linked; these findings indicate that, in this model, thyroid is a target organ of the immunological conflict.