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THE EFFECT OF CYPROHEPTADINE ON OXIDATIVE PHOSPHORYLATION IN RAT LIVER MITOCHONDRIA

The ability of cyproheptadine to modify appetite (Oomura etal 1973) would appear to be secondary to its known action as a potent 5-hydroxytryptamine antagonist or anti-histamine agent (Pawlowski, 1975) and therefore the mechanism by which this compound stimulates food intake during the treatment of anorexia remains unknown. Recent invivo experiments have shown appetite modifying agents to be capable of changing intracellular energy production (McNamee etal 1985). The present study investigates the invitro effects of appetite-modifying agents on mitochondrial adenosine triphosphate formation.