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The role of autophagy in age‐related macular degeneration (AMD) – studies into the pathogenesis of AMD

Age-related macular degeneration (AMD) is themajor reason for blindness and visual impairment in the developed countries. The prevalence of AMD is increasing due to the rise in life expectancy. There are estimations that the number of AMD patients will at least triple in the upcoming decades. About eight in 10 of AMD patients suffer from the untreatable dry form of AMD. The progression of wet AMD can be slowed downor in some cases even stoppedwith anti-vascular endothelial growth factor medications. Nonetheless, the pathogenesis of AMD has been a somewhat mysteryuntil recent discoveries. It seems that chronic oxidative stress evokes disturbances in proteasomal and autophagy clearance that secondarily leads to inflammation.