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1432 31-PHOSPHORUS NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY IN SMALL FOR GESTATIONAL (SGA) INFANTS

31-Phosphorus nuclear magnetic resonance (NMR) spectroscopy was used to sequentially study cortical metabolism in nonasphyxiated, premature SGA infants, with a mean birth weight of 1325 gm (range 1260-1360 gm) and mean gestational age of 33.8 wks (range 32-35 wks). Studies were obtained beginning after 2 wks of age. Phosphocreatine (PCr)/inorganic phosphate (Pi), a measure of bioenergetic reserve, phosphodiesters (PD)/beta adenosine trisphosphate (ATP), and phosphomonesters (PME)/ ATP, a precursor of membrane lipids, were obtained in premature SGA infants and compared with those in appropriate-for-gestational-age (AGA) infants of similar gestational age and with term infants:The lower bioenergetic reserve noted in premature SGA infants may be due to decreased substrate availability or increased utilization, secondary to chronic intrauterine deprivation. As PD/ ATP and PME/ ATP do not appear to be affected by growth retardation, they may be promising markers of gestational maturity.