{'fraction_non_alphanumeric': 0.029411764705882353, 'fraction_numerical': 0.011312217194570135, 'mean_word_length': 5.413043478260869, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Role of the PROS1 gene in thrombosis: lessons and controversies

The PROS1 gene codes for the vitaminK-dependent plasma protein, protein S (PS), an essential anticoagulant and multifunctional protein. The association of PS with thrombosis [1] is well established, but the particular anticoagulant activity or activities of PS that are compromised in thrombosis are not entirely clear and the effects of PS deficiency on more recently discovered functions of PS in inflamma tion, apoptosis and receptor activation are unknown. Lessons can be learned from the phenotypes of reported mutations and polymorphisms in the PROS1 gene, but many questions and controversies remain. For greater depth, the reader is referred to extensive databases of PS mutations [2,3], recent reviews [4,5] and molecular models that rationalize PS mutations [6,7]. PS cofactor activity for activated protein C