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Energy dependent normalization method in positron emission tomography (PET)

During the reconstruction process, scatter correction and normalization needs to be applied to correct raw PET data. Normalization corrects for all the variations between the detector responses and typically consists of various components each representing specific physical effect. Only one set of normalization components is typically estimated for the clinical energy window. However, some of the components might change depending on the energy of the detected photons within the clinical imaging window. In this work, we investigated the need for accounting for such dependency in clinically used energy window.