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Neural dynamics in mental disorders

The search for the pathophysiological substrates of mental disorders remains an important challenge for psychiatric research. While major psychiatric conditions have a biological signature that can be identified with a range of neuroimaging approaches, biomarkers that allow reliable differentiation between different conditions as well as detection at early-illness stages have yielded only modest success. Given the importance of early intervention in a range of disorders as well as the move towards personalized medicine (1), understanding the underlying neurobiology is of crucial importance towards the development of more effective treatments and care.