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Influence of the Mobile-Phase Modifier on the Retention of Some para-Substituted Amides; Correlation with Compound Lipophilicity

Summary The chromatographic behavior of para-substituted amides of αphenylacetic, benzoic, propanoic, and 2,2-dimethylpropanoic acid has been studied in reversed-phase thin-layer chromatography on silica gel impregnated with paraffin oil. Mobile phases used were acetone–water, methanol–water, and dioxane–water. RM 0 values were calculated by linear extrapolation of retention to 0% organic modifier for each mobile phase. The relationships between R M 0 values obtained with different organic modifiers in the mobile phases are discussed. C 0 values were obtained from the slopes and intercepts of linear relationships between retention and volume fraction of modifier. Correlation between partition coefficient, log P, and R M 0 and between log P and C 0 was examined. Results show that C 0 is a better measure of the lipophilicity of the amides than R M 0.