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Histologic Evaluation of a Cornea in a Patient With Apolipoprotein A-I Deficiency

Purpose: To report the histology of a cornea in a patient with apolipoprotein A-I (apoA-I) deficiency. Methods: A cornea from a patient with apoA-I deficiency was obtained by keratoplasty and examined histologically. Results: There were many small vesicles in the extracellular matrix throughout the corneal stroma. The vesicles were round or oval, and their diameters ranged from 200 nm to 2 μm. These histologic properties suggest that the small vesicles are lipid droplets. Conclusions: Myriad lipid droplets in the extracellular matrix in the corneal stroma induce diffuse corneal opacity in a patient with apoA-I deficiency.