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Differentiation in a Physiologically Relevant Oxygen Microenvironment : Differential Response of Chondrocytes and Infrapatellar Derived MSCs Undergoing Chondrogenesis

Introduction MSCs derived from knee joint tissues such as the infrapatellar fat pad possess significant chondrogenic potential [1, 2]. Current tissue engineering or regenerative medicine strategies typically involve culturing chondrocyteor MSC-seeded constructs in normoxic conditions (21%). In vivo oxygen tensions decrease with depth from the cartilage surface with mean oxygen tensions estimated at about 6-8% at the superficial zone [3]. This study investigates the influence of a physiologically relevant, low oxygen environment (5%) on functional properties of cartilaginous tissues engineered using chondrocytes and infrapatellar fat pad derived MSCs compared to normoxia (21%).