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Grants and Contracts

INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARD (U54): RFA-RM-07-002 National Institutes of Health (NIH) This request for applications (RFA) is developed as a Roadmap initiative. All NIH Institutes and Centers participate in Roadmap initiatives. This RFA will be administered by the National Center for Research Resources (NCRR) on behalf of the NIH. Application receipt date: January 17, 2007 Growing barriers between clinical and basic research, along with the ever-increasing complexities involved in conducting clinical research, are making it more difficult to translate new knowledge to the clinic—and back again to the bench. These challenges are limiting professional interest in the field and hampering the clinical research enterprise at a time when it should be expanding. The purpose of this initiative is to assist institutions to create a uniquely transformative, novel, and integrative academic home for clinical and translational science that has the resources to train and advance a cadre of well-trained multiand interdisciplinary investigators and research teams with access to innovative research tools and information technologies to promote the application of new knowledge and techniques to patient care. Clinical and Translational Science Awards (CTSAs) will attract basic, translational, and clinical investigators; community clinicians; clinical practices; networks; professional societies; and industry to develop new professional interactions, programs, and research projects. Through innovative advanced degree programs, CTSAs will foster a new discipline of clinical and translational science that will be much broader and deeper than their separate components. To succeed, CTSAs will need institutional support and the status of a major administrative entity within the applicant institution and a principal investigator (PI) who has authority, perhaps shared with other high-level institutional officials, over requisite space, resources, faculty appointments, protected time, and promotion. NIH anticipates that diverse models will be proposed to fulfill these goals and welcomes innovative proposals that meet the needs of both the local institution and the wider research community. This RFA invites applications for institutional CTSAs that will enable applicants to innovate and to transform their own environment to develop and advance clinical and translational science as a distinct discipline. NIH Roadmap resources will give institutions the flexibility to develop their existing resources and talent and to propose ways to increase the efficiency and speed of clinical and translational research. The academic home, which can be a center, department, or institute (C/D/I), is expected to include faculty who conduct original research, develop graduate and postgraduate training curricula, and lead programs that integrate clinical and translational science across multiple departments, schools, research institutes, and hospitals. Applicants will be expected to define the key functions, components, governance, and structure of their C/D/I. They should describe the existing and planned activities that would be integrated to create the CTSA and the role that the participating schools and departments within the applicant organization, affiliated institutions, community, foundations, and industry would play. The C/D/I will provide career paths in clinical and translational science through research education, training, and career development leading to advanced degrees (MS or PhD). The C/D/I will work in close cooperation with activities of the NIH Roadmap, NIH Institutes and Centers, and other appropriate trans-NIH activities. The C/D/I at each institution will be expected to complement and interact with existing centers that are funded by the categorical institutes of the NIH and to interact with affiliated institutions and industry. The total funds available for the new awards are approximately $38 million. Awards will vary in size owing to the consolidation of multiple programs within the CTSA program. Applicants may request total costs up to $6 million annually for 5 years in addition to the combined current total costs of certain NIH awards (NCRR K12, K30, M01 and Roadmap T32 and K12) held by the applicant institution and its affiliates as stated as ‘‘Approved Budget’’ in the last Notice of Grant Award issued prior to October 1, 2006. Revised applications should use the NIH award budget base of the previous, unsuccessful application. If the application is successful, all of the above-listed awards at each participating institution will be reconfigured into the CTSA program. It is possible for more than one of each type of award to be included in the CTSA and for more than one institution to participate in a single CTSA; however, a single institution can participate in DOI 10.2310/6650.2006.X0028