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Studies on the afferent and efferent lymph of lymph nodes draining the site of application of fluorodinitrobenzene (FDNB).

Peripheral lymph (afferent to the popliteal node) or intermediate lymph (efferent from the popliteal or prefemoral node) was collected from unanaesthetized sheep before and after painting the skin of the drainage area with a 10 per cent solution of fluorodinitrobenzene (FDNB) in acetone. In some experiments FDNB labelled with tritium ([3H]FDNB) was used. 
 
The changes in the cell population of efferent lymph from nodes thus stimulated were generally similar to those which occur following stimulation with conventional antigens, i.e., between 90–120 hours later many large basophilic lymphoid blast cells (immunoblasts) appeared in the lymph and specific antibody appeared in the lymph plasma. 
 
Studies with [3H]FDNB showed that although some of it appeared in afferent lymph almost immediately after application, substantial amounts were not present usually until 20 hours or so later. All of the FDNB in the afferent lymph was bound to soluble proteins in the plasma and none was found in association with the lymph cells. Apparently, this protein bound FDNB was inefficiently phagocytosed in the regional node because much of it passed through the node so that it could be recovered in the efferent lymph for 100 hours or more following the original application. 
 
It was concluded that skin sensitizing chemicals of the FDNB class are transported to the node after they have combined with soluble proteins that enter the lymph; in the combined form they behave like other soluble protein antigens and provoke similar cellular responses in the regional tissue.