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Treatment of vertebrobasilar insufficiency. Use of calcium antagonists.

The influence of various calcium-entry blockers on the vestibular system was investigated. This paper reports results from animal experiments and also from clinical studies with Flunarizine and Nimodipine. An animal experimental model of vertebrobasilar insufficiency was developed. The effect of these drugs on vestibular nystagmus was studied in Alsatian dogs before and after occluding one vertebral artery. In order to analyse the influence of these drugs on the vestibular nystagmus and on the clinical symptoms in patients with vertebrobasilar insufficiency, different open and double-blind studies were performed.