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The importance of descending modulatory pain systems

The landmark paper discussed in this chapter is ‘Descending control of pain’, published by M. J. Millan in 2002. The perception of pain is affected by a complex interaction between nociceptors in the dorsal horn of the spinal cord, systems that transfer messages to cerebral structures. The complex interaction between the CNS and the peripheral nervous system in a modifiable and plastic neural system makes the perception of pain unique for each individual. In this regard, the author outlines the neurobiology of pain, providing a detailed description of the descending pathways which modulate the activity of spinal nociceptors which are located in the dorsal horn and which transfer nociceptive messages to cerebellar structures.