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Is the glutathione S‐conjugate pump a flippase?

A hypothesis of the flippase nature of the glutathione S‐conjugate transport is presented. Experimental premises for this hypothesis include interaction of glutathione S‐conjugates with the membrane, as demonstrated by their effects on membrane fluidity, quenching of 1‐(4‐trimethylammoniumphenyl)‐6‐phenyl‐1,3,5‐hexatriene fluorescence and induction of echinocytosis by 2,4‐dinitrophenyl‐S‐glutathione (DNP‐SG). This hypothesis can rationalize, i. a., observations of the enhancement of DNP‐SG transport by butanol and stimulation of erythrocyte membrane Mg2+‐ATPase activity by albumin‐coupled DNP‐SG.