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Regulation of Glycogenolysis and Pyruvate Oxidation in Human Skeletal Muscle In Vivo

It is well established that glycolysis increases dramatically in skeletal muscle during heavy exercise. Most of the glucose moieties used for the increased glycolysis are derived from muscle glycogen stores, although a significant portion may be derived from blood glucose. The intent of the present studies was to determine the important regulatory factors controlling human skeletal muscle glycolysis during heavy exercise.