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Epithelioid hemangioma in the oral mucosa – A case report.

Introduction
Epithelioid hemangioma is an uncommon benign vasoproliferative neoplasm that usually
manifests as multiple red nodules in middle-aged adults


Case Outline
52-year-old male patient presented with a one-year history of a nodular lesion in the
left buccal mucosa measuring 3 cm. The clinical hypothesis was lipoma. An excisional biopsy revealed a
circumscribed lesion composed of lobules of vessels with perceptible or poor lumina, associated with a
prominent inflammatory infiltrate consisting of eosinophils, histiocytes and chronic inflammatory cells.
The endothelial cells composing the lesion had an epithelioid morphology and contained abundant
eosinophilic cytoplasm. Immunohistochemistry for CD34, factor VIII, collagen IV, alpha-smooth muscle
actin, and mast cells, as well as histochemical staining with Weigert’s orcein were performed.


Conclusion
Vascular proliferations of soft tissues are a diverse and morphologically complex group of
lesions that are difficult to diagnose. This report presents a case of oral epithelioid hemangioma, highlighting
relevant morphological and immunohistochemical features that could help distinguish this
condition from other neoplasms.