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Prognosis in renal carcinoma

The factors influencing prognosis have been analyzed in 100 patients with renal carcinoma, collected as a prospective study. Malignancy grading was valuable in determining prognosis in an individual case, but staging gave an even better correlation with survival. Multiple regression analysis demonstrated that the 2 most important factors were the presence of remote metastases and an elevated E.S.R. Grade, size of the tumor, and invasion of the renal vein also correlated well with prognosis but were of less importance than metastases and E.S.R. A prognostic index, including the effect of all these variables, showed good agreement with individual survival. An elevated E.S.R. per se, i.e., without metastases, was compatible with a high rate of survival.