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Plasma concentrations and excretion of zipeprol in man under acidic urine conditions

Plasma concentrations of zipeprol, and the urinary excretion of it and two of its basic metabolites, compound II and compound III were examined after oral administration of zipeprol hydrochloride to man. The drug was rapidly and extensively metabolized, and the amount of unchanged drug excreted in the acidic urine varied from 1–5% of the dose; the two basic metabolites accounted for 19–38% of the dose.