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Effects of local structure on electrocatalytic behavior of doped RuO

C427 among the B-family DNA polymerases, which include all eukaryotic replicative DNA polymerases, E. coli DNA pol II and eukaryotic pol ζ are exceptional and specialized for translesion and mutagenic DNA synthesis (2). In this presentation, different mechanisms of translesion synthesis by a B-family member and the Y-family human DNA pol η will be discussed. The key to the specificity of DNA polymerases, whether in high-fidelity replication or translesion synthesis, appears to be two Mg2+ ions essential for the catalysis.