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Generalized pustular psoriasis precipitated by trazodone in the treatment of depression

Severe psoriasis is commonly associated with depression and may be its cause. The hazards of treating such patients with lithium are well known (Lazarus & Gilgor, 1979), but other drugs may also destabilize psoriasis. We report a patient in whom the anti‐depressant trazodone hydrochloride (Molipaxin®, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).