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Non-clinical toxicity study of the oil-resin and vaginal cream of Copaiba (Copaifera duckei, Dwyer)

Abstract The toxic effects of copaíba oil-resin (ORC) and the copaiba oil-resin vaginal cream (CVC) were evaluated in subacute treatment phase, in wistar rats, which were treated orally (p.o) and intravaginal (ivag). Treated groups received the dose of, 0.04 mg/kg, 28 mg/kg, and 32 mg/kg, respectively, with ORC (p.o), Copaifera duckei oil-resin (ORCV-ivag) and vaginal cream with oil-resin C. duckei (CVC – ivag). The treatment for 22 days with ORC and CVC did not cause clinical signs of toxicity, no deaths have been reported, and did not change the development weight of the animals. The females treated with ORC (p.o), exhibited greater intake of water, but the feed intake was not different in males and females. The use of CVC did not change the water intake of females, but altered feed intake. The ORCV was capable of causing hypoglycemic effect and elevated serum creatinine levels. The hematology parameters of the animals were not changed by ORC (p.o, 32 mg/kg). The use of CVC changed hematocrit, lymphocytes, and the concentration of hemoglobin. The use of CVC and ORCV (ivag), did not altered the biochemicals parameters. Females treated with ORC (p.o, 32 mg/kg) showed some kind of susceptibility to specific use (elevation of total cholesterol, HDL and alkaline phosphatase). The elevation of serum ALT and AST enzymes was not attributed to the use of ORC orally and intravaginal and the use of CVC, as well as the product of its formulation (BVC). The subacute treatment with C. duckei oil-resin and cream (CVC) did not cause clinical signs of toxicity, no deaths have been reported and did not change significantly the parameters evaluated in this study.