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Hexamethylmelamine in advanced head and neck cancer A phase II study

THE RESULTS OF HEXAMETHYLMELAMINE THERAPY in 20 patients with advanced squamous cell head and neck cancer are reported. No patient had previously received chemotherapy. The dose of hexamethylmelamine was 8 mg/kg/day p.o. There was partial response in 3/20 (15%) patients. The duration of the response was 6–10 weeks. Twelve of 20 (12/20) patients had stable disease for a median of 8 weeks (range: 4–18 weeks). Hexamethylmelamine was well tolerated with the only significant toxicity being mild nausea and vomiting. This drug deserves further evaluation in the treatment of head and neck cancer.