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Theophylline pharmacokinetics after intravenous infusion with ethylenediamine or sodium glycinate.

Six healthy volunteers received two theophylline preparations by short intravenous infusion, at weekly intervals in a randomized cross-over design. The solubilizer was ethylenediamine or sodium glycinate. Plasma concentrations of theophylline and ethylenediamine were measured by h.p.l.c. for up to 24 h after dosing. The pharmacokinetics of theophylline did not show any significant intra-subject variation associated with the solubilizing agent used.