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[Effect of antibiotics on Na(+),K(+)-ATP-ase activity of the membranes in the Misgurnus fossilis L. embryos].

The influence of some antibiotics of the fluoroquinolone classes on the Na+, K(+)-ATP-ase activity of loach embryo (Misqurnus fossilis L.) was investigated at different stages of blastomer divisions. It was determined that norofloxacin and borocin induce a dose-dependent decrease in Na+, K(+)-ATP-ase activity. Addition of norofloxacin (5.25 mcg/ml) into the incubation media caused pronounced oscillations in Na+, K(+)-ATP-ase activity, following borocin addition (5,15.25 mcg/ml) this effect was less pronounced. A conclusion was drawn about the influence of the fluoroquinolone on the membrane level.