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Granulocyte microbicidal function in patients undergoing major abdominal surgery under balanced anaesthesia

Granulocyte microbicidal functions were studied in 11 major abdominal surgery patients with the luminol‐enhanced chemiluminescence method. The responses of granulocytes in phagocytosis of zymosan, S. aureus and E. coli and responses to N‐formylmethionyl‐leucylphenylalanine (FMLP) were unaffected by surgery. The percentage of high‐peroxidase‐activity cells among neutrophils was increased on postoperative days 1 (P<0.01) and 3–4 (P<0.05). We propose that microbicidal‐related oxidative phagocytic functions of granulocytes are well maintained after major abdominal surgery under balanced anaesthesia.