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Prognosis in pregnant women with systemic lupus erythematosus following pregnancy management

This study was aimed to understand the effects of pregnancy management in the prognosis for pregnant women with systemic lupus erythematosus (SLE). A total of 217 pregnant patients who were diagnosed with SLE were divided into two groups, the control group (n = 96) and the intervention group (n = 121). The intervention group was treated with routine treatment and nursing care with additional pregnancy management, while the control group was treated with only routine treatment and nursing care. Additionally, 195 normal pregnant women were selected as the healthy controls in the same period. No significant difference of clinical features was observed in the three groups. Compared with the healthy control, increased ANA titer and dsDNA, lower immunoglobulin complement, renal damage, blood system damage, increased SLEDAI score and BILAG score were observed in the control group and the invention group. Both the control group and the intervention group showed significant increases in the incidences of PIH, premature delivery, fetal loss and neonatal complications as well as a significant decrease in neonatal weight compared with the healthy control. SLE activity rate and incidences of PIH, premature delivery and neonatal complications were significantly decreased; while neonatal weight was greatly increased in the intervention group compared with the control group. Low immunoglobulin complement, renal damage, increased dsDNA, and low immunoglobulin complement were independent risk factors for increased SLE activity rate, fetal loss, premature delivery and neonatal complications, respectively. The present study indicates that pregnancy management for pregnant SLE patients could significantly improve maternal and neonatal outcomes.