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The Immunological Basis of Glomerulonephritis

The availability of experimental models of glomerulonephritis has been a major factor in the growth of knowledge of this subject. A detailed review of experimental allergic glomerulonephritis was presented by Unanue & Dixon (1967). More recently much information has been obtained from immunopathological studies of human nephritis, and it is this aspect that I shall emphasize. However, I will first summarize the principal events in experimental allergic glomerulonephritis to provide a background against which the immunological mechanisms of human glomerulonephritis can be more readily understood.