{'fraction_non_alphanumeric': 0.023614895549500452, 'fraction_numerical': 0.002270663033605813, 'mean_word_length': 5.675757575757576, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Primary biliary cirrhosis and pernicious anemia

the end stage of this type of gastritis. In other words, pernicious anemia evolves almost exclusively from type A gastritis. A genetic predisposition to type A gastritis is suggested by the clustering of autoimmune diseases and of gastric autoantibodies in families. Recently, the proton pump H, K-adenosine triphosphatase (H, KATPase) of parietal cells was confirmed to be the major humoral autoantigen in both human and experimental autoimmune gastritis characterized by an inflammatory infiltrate in the gastric mucosa and a loss of parietal cells. An association with other autoimmune endocrinopathies, such as Hashimoto’s thyroiditis, Addison’s disease, insulin-dependent diabetes mellitus, and idiopathic adrenocortical insufficiency has also been previously reported, and pernicious anemia is known to be one of the component disorders of autoimmune polyglandular syndrome. One particularly attractive theory is the concept of molecular mimicry, which is based on the principle that a common epitope between the bile duct epithelial cell and the parietal cell initiates an autoimmune response and subsequent immunopathology by generating autoreactive lymphocytes and/or antibodies. As Takahashi et al. mentioned in their report, no significant amino acid sequence homology or even similarity of both PDC-E2 and H, and K-ATPase could be found in the Genebank database. An association with various kinds of autoimmune diseases is one of the characteristics of PBC. Associated diseases include Sjögren’s syndrome, Hashimoto’s thyroiditis, rheumatoid arthritis and calcinosis, Raynaud’s phenomenon, esophageal dysfunction, sclerodactyly and telangiectasia (CREST) syndrome. However, immunoserologically, in addition to AMA, PCA is frequently detected in patients with PBC, as in the case of atrophic corpus gastritis. Oya et al. reported that severe and extensive gastric mucosal atrophy was manifested in autoimmune liver diseases, including PBC, which exhibited positive PCA. However, although the stomach can also be regarded as an exocrine organ, the association of PBC with atrophic corpus gastritis or pernicious anemia See article on page 1420