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COVID-19: immune response and its implications for disease monitoring and therapy

Immune disorders are currently recognized as the major cause of aggravation of clinical symptoms in corona virus disease 2019 (COVID-19) patients. This review summarized the characteristics of the immune response to COVID-19 from the abnormal dynamics of lymphocyte subsets, including the decrease in the count of natural killer cell and T cell subsets and the large accumulation of cytokines during disease progression. This review also clarified the possible mechanisms of changes in key lymphocyte subsets and the dynamic of cytokines. Thus, it provided new strategies for clinical treatment and granted potential targets for drug discovery.