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An evaluation of the efficacy of adenovirus-mediated gene therapy with p53 for the treatment of cancer

Cancer is the second leading cause of mortality in the United States today, and equally prevalent throughout the world. Traditional treatments such as chemotherapy and radiotherapy have thus far proven unable to treat the disease with high efficacy, with different cancer types often requiring different treatments providing a spectrum of results. Cancer types in the late stages often have no adequate treatment at all. Over the past two decades, research in the field of gene therapy has created new hope in finding a remedy for cancer that displays a high efficacy in treating many different types and stages. The p53 tumor suppressor gene has garnered a great deal of interest, as p53 mutation or inactivation is present in approximately 50% of all cancers. The loss of p53 activity can be attributed to several different causes, including mutation of the p53 gene or overexpression of p53 inhibitors. Research has illustrated that the p53 protein plays an important role in tumor suppression by inducing senescence, cell cycle arrest, or cell apoptosis. Studies have shown that