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Panda eye sign on diffusion weighted-MRI for the diagnosis of methotrexate-induced subacute leukoencephalopathy

Cancer Research, Statistics, and Treatment / Volume 2 / Issue 2 / July-December 2019 In this intriguing original article, Mahajan et al. have performed a retrospective analysis of adult acute lymphoblastic leukemia (ALL) patients who were treated with Berlin–Frankfurt– Munster‐90 protocol and found a consistent imaging finding of restricted diffusion in the centrum semiovale resembling ‘panda eyes’ in diffusion‐weighted (DW) magnetic resonance imaging (MRI) of the brain among patients who developed methotrexate (MTX)‐induced subacute leukoencephalopathy.[1]