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[Long term results of treatment of highly-malignant non-Hodgkin lymphoma in the elderly (70 years and older)].

OBJECTIVE
To assess retrospectively the results of long-term combined chemotherapy and radiotherapy of patients 70 years of older, taking into account the international non-Hodgkin lymphoma (NHL) prognostic index of Shipp as well as the dose-intensity.


PATIENTS AND METHODS
Of 303 patients treated for aggressive NHL 100 were aged 70 years or more (median age 76 years). Localized stages I or II were present in 56, advanced stages III or IV in 44, and 38 had extranodal tumours. 92 patients were given multiple-drug chemotherapy according to the CHOP or COP BIAM protocols (n = 89 and 3, respectively), followed by single large-field or "involved field" radiotherapy with the aim of consolidation (n = 49) or cure (n = 26).


RESULTS
Recurrence-free and total survival probabilities were 32% and 30%, respectively. 54 patients with stages I or II survived 10 years, but only six survived just 4 years with stages III or IV. There were five treatment-associated deaths.


INTERPRETATION
Combined chemo- and radiotherapy can achieve long-term remission in most even elderly patients with localized stages of aggressive NHL.