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Synthesis of S-100 protein in monolayer cultures of rat-glial cells.

Synthesis and degradation of the brain-specific S-100 protein were measured in monolayer cultures of clonal rat glial cells C 6. The cells synthesize a small but definite amount of S-100 protein in logarithmic growth. The increase in accumulation of S-100 protein which occurs at the end of logarithmic growth is brought about by changes in synthesis.