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26 th Annual Meeting of the Society for Clinical Trials Full Conference

Group sequential methods have traditionally been used in clinical trials to evaluate potential trial-stopping based on interim results. More recently, flexible or adaptive methods have been proposed as alternatives, in which the sample size may be adjusted based on interim results. There are many ongoing debates about the efficiency and implementation of these adaptive trial designs as compared with group sequential designs. In this session, the speakers will provide insightful views and comparisons of these methods in terms of trial design, implementation, efficiency, and operational issues. They will also illustrate the utility of these methods with specific examples.