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Aprotinin reduces hypothermic mortality-an experimental model

In order to test the postulate that posthypothermic damage may be caused by protease activation, the effect of the administration of aprotinin on hypothermic mortality was investigated in anaesthetized rabbits. A group of 6 animals received 40.000 KIU aprotinin intravenously prior to the induction of hypothermia by surface cooling and this was followed by a further 35.000 KIU each hour for 5 h. The animals were cooled to 29°C and then rewarmed. A control group received equal volumes of physiological saline. The aprotinin treated animals survived, whereas all the control group died within 7 days, 5 of them within 24 h. The haemodynamic, biochemical and haematological changes in the two groups are reported.