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association between body mass index and cardiovascular-related mortality

The relationship between body mass index (BMI) and cardiovascular (CVD) related mortality has been extensively investigated in the general population. However, the research on this matter is relatively limited, and the conclusions from these studies are inconsistent. This study aimed to review the association between body mass index with CVD related mortality. Articles that reported hazard ratio (HR) for all-cause mortality using standard BMI categories of general populations of adults were selected from the following databases including PubMed, ProQuest, Springer link, and Science direct for English language articles published until 2022. Ten studies were included in this study. Random and Fixed-effects summary of CVD-related mortality HRs were 1.72 (95% CI, 1.51-1.97) for underweight, 1.40 (95% CI, 1.15-1.69), and 1.33 (95% CI, 1.17-1.52) for obesity. Being underweight and obese might increase CVD related mortality in all populations, including males and females.