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Results of ofloxacin therapy in andrologic patients suffering from therapy‐requiring asymptomatic infections

Summary. In 1990, microbiological ejaculate analyses were carried out on a routine basis on 125 andrological patients, in addition to the determination of the concentration, motility and morphology of the spermatozoa. Fourteen patients (11.2%) with therapy‐requiring asymptomatic infections (TAI)>104 CFU (colony‐forming units) ml−1 were effectively treated with Ofloxacin (TarividR) at 2 times 200 mg d−1 for a period of 20 d. Concentration, motility and morphology of the spermatozoa were determined before the Ofloxacin treatment and controlled 1, 3, and 6 months later and correlated to the values obtained before the treatment. Over the entire period of observation, the morphology did not change significantly, whilst initially 1 month after the treatment the concentration and the motility decreased significantly (P<0.05). Three months later they again reached the starting values. After 6 months, a significant improvement occurred with regard to the motility, as compared to the starting values (P<0.01), whilst the concentration remained at the level of the starting values.