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Chromosome aberrations in patients with paranoid psychosis.

Axelsson, R. and Wahlstrom, J. 1984. Chromosome aberrations in patients with paranoid psychosis. —Hereditas 100:29–31. Lund, Sweden. ISSN 0018–0661. Received March 21, 1983 
 
 
 
By means of C- and G-banding techniques, 134 consecutive patients with paranoid psychosis and 26 controls without psychiatric disorders were screened for chromosome aberrations. About one third of the patients showed chromosome aberrations, whereas no such changes were found among the controls. The difference was highly significant. The most common findings were: duplication in the heterochro-matin regions (15 %), inversion on chromosome 9(10%), fragile sites on chromosomes 9 and 17 (about 4 %), and sex chromosome aberration (about 2 %). One patient had a translocation between chromosomes 5 and 6, another an inversion on chromosome 10. The findings are compared with the results of earlier studies on selected and unselected materials.