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Influence of antisecretory drugs on Helicobacter pylori eradication rates.

We read with great interest the article by Sherwood and colleagues ( Gut 2002; 51 :490–5) evaluating the role of acid secretion and gastric luminal pH on the gastric transfer rate of amoxycillin, clarithromycin, and metronidazole. The study showed that metronidazole and clarithromycin but not amoxicillin transfer was increased by acid secretion. Gastric acid suppression, induced by the use of omeprazole, produced the fall in clarithromycin and metronidazole transfer.

These data may help to clarify preliminary results of our study on Helicobacter pylori eradication in a population of 120 H pylori infected dyspeptic patients (63 males and 57 females; mean age 53.2 (12.31) years).1 None of the patients received prior antibiotic treatment with nitroimidazoles or macrolides, or H pylori eradication therapy, nor was there a history of gastrointestinal surgery, alcohol use, or smoking.

Our population was divided in two groups of 60 patients who underwent two different 14 day triple eradicating regimens based on …