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Metabolism and excretion of chromonar and its metabolite in dog and man.

A simple method for the detection of chromonar and its acid metabolite by fluorescence techniques is described. Following oral or intravenous administration, chromonar is rapidly hydrolyzed to its metabolite, the corresponding acid. No further metabolism is observed. The metabolite distributes according to a single-compartment model. The plasma half-life is 1 hr. in man and dog. Excretion of the metabolite into the bile accounts for approximately 25% of the dose, and excretion into the urine accounts for the remainder.