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Lymphoid-cell renewal under low-level irradiation. XI. The cell cycle and growth kinetics during radiation leukemogenesis in C57BL mice.

Studies of thymus-cell population kinetics suggest that during leukemogenesis, changes in the control of cell growth and division occur in cells undergoing differentiation and in those which are functionally mature as well as in proliferating cells, thus disturbing the rate of cell flux and transition from one phase of cell maturation to another. Progressive breakdown of cellular control mechanisms may be involved.