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Pholcodine stimulates a dramatic increase of IgE in IgE‐sensitized individuals. A pilot study

Background:  A previous study showed a relation between pholcodine (PHO) consumption, prevalence of IgE‐sensitization to PHO, morphine (MOR) and suxamethonium (SUX) and anaphylaxis to neuromuscular blocking agents (NMBA). The purpose of this pilot study was to explore the effect on IgE production, in IgE‐sensitized and nonsensitized individuals, of exposure to cough syrup and environmental chemicals containing PHO, MOR and SUX related allergenic structures.