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Nutritional factors determine germ tube formation in Candida albicans.

Following a short (3 h) period of carbon starvation, exponential phase yeast cells of Candida albicans rapidly (T50 45 min) formed germ tubes in a glucose/ammonium ion solution. The presence of both a sugar (glucose, sucrose or galactose) and a nitrogen source (ammonium ion or an amino acid metabolized via glutamate) was critical for morphogenesis.