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Bacterial invasion induces interleukin‐7 receptor expression in colonic epithelial cell line, T84

The intestinal epithelial layer forms the interface between the external and the internal environments of a host. Since the interleukin‐7 (IL‐7) and IL‐7 receptor (IL‐7R) signaling pathway has been shown to play an important role in the mucosal immune system, we studied the expression of IL‐7R in T84, a colonic epithelial cell line, after cells were infected with several types of enteropathogenic bacteria, including Salmonella typhimurium, enteropathogenic Escherichia coli and enteroinvasive Escherichia coli. Bacterial invasion induced IL‐7R expression in T84 assessed by a semi‐quantitative reverse transcription‐polymerase chain reaction technique and flow cytometry. The inhibition of bacterial invasion by cytochalasin D, a specific inhibitor of actin polymerization, led to a reduction in the expression of IL‐7R. These data indicate that bacterial invasion into intestinal epithelial cells is likely to be an essential process in the induction of IL‐7R. The communication between the epithelium and mucosal lymphocytes which is mediated via IL‐7 and IL‐7R may be involved in the modulation of the mucosal inflammation which occurs in bacterial infection.