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Cellular localization of class I (HLA‐A, B, C) and class II (HLA‐DR and DQ) MHC antigens on the epithelial cells of normal human jejunum

HLA class I and class II (HLA‐DR (human I‐E equivalent) and DQ (human I‐A equivalent] antigens were localized by immunofluorescence technique on thin frozen sections of normal human jejunum using a panel of monomorphic monoclonal antibodies. HLA class I (A, B and C) and HLA‐DR molecules were found in the basolateral membrane of enterocytes; HLA‐DR were also detected in a patchy distribution in the apical part of enterocytes; HLA‐DQ molecules (the human equivalent of the murine I‐A molecular subset) were not detected on normal enterocytes. All three molecules were detected on the membrane of lymphocytes and monocytes present in the lamina propria.