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Impact of Immune Function on Aerobic Capacity in Rats

The use of immunocompromised animals has been indispensable in cancer and immunology research. The use of exercise with these models in these areas of research has increased dramatically over the past decade, with little to no evidence of how immune modification of strains of animals is impacting exercise capacity and/or responses to training. This data is critical for extrapolation to exercise recommendations in humans as the majority of cancer patients do not present with primary immunodeficiency diseases. Recently, observations of lower skeletal muscle oxidative capacity between RNU (NIH Nude, immunocompromised) and Copenhagen rats (immunocompetent) have been speculated to result from possible differences between immune function in animals. The purpose of this study was to determine if there are differences in maximal aerobic capacity, through assessment of V̇o2max, between immune‐competent and ‐compromised animals of the same strain. We tested the hypothesis that immunocompromised animals would have a lower aerobic capacity than their immunocompetent counterparts.