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In-vitro contrast agent detection combining pulse inversion and SURF imaging

Microbubbles as an ultrasound contrast agent have great diagnostic value, and can be used to visualize the vascularization in a variety of organs, e.g. imaging the neo-angiogenesis in tumors. Pulse inversion (PI) is a common method for detection of these bubbles, implemented in many ultrasound scanners. A dual band imaging technique named SURF has shown the ability to further enhance contrast-to-tissue ratio (CTR) in imaging of microbubbles. A new method is proposed here that combines the two techniques, potentially resulting in even better CTR.