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Functional ultrasound imaging can detect vascular changes in tau P301S mouse model of Alzheimer’s disease

Tauopathies are neurodegenerative disorders characterized by the accumulation of abnormal tau protein leading to cognitive and/or motor dysfunction. Evidence suggests that tauopathy mouse models develop changes in blood vessel morphology, density and altered cerebral blood flow, which could be linked to cognitive deficits in Alzheimer’s Disease. Here we assess changes in neurovascular coupling in Tau P301S mouse model (MAPT P301S, PS19) using functional ultrasound (fUS) and its relationship to histological changes and cognitive deficits.