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Higher Membrane Permeability Predicts Poorer Patient Survival

The CANUSA trial recently reported higher mortality in patients with lower KTN and worse nutritional status ( 1). A separate analysis of the same data showed worse technique and patient survival with increased membrane permeability (2). This is intriguing because patients with higher dialysatel plasma (D/P) creatinine would be expected to have a higher KTN (though a lower serum albumin), than those with lower membrane permeability (3). Patients in the highest peritoneal equilibration test (PET) group had the worst survival. We decided to examine these apparently contradictory results.