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Tenidap, but not Nonsteroidal Anti‐Inflammatory Drugs, Inhibits T‐Cell Proliferation and Cytokine Induction

T‐lymphocytes are involved in the inflammatory response that occurs in affected joints of patients with rheumatoid arthritis (RA). Some second‐line disease modifying anti‐rheumatic drugs used in the treatment of patients with RA are known to block T‐cell activation. The present study assessed whether tenidap, an investigational anti‐rheumatic drug, affects in vitro T‐cell responses such as proliferation and cytokine production. It was found that tenidap, in contrast to several nonsteroidal anti‐inflammatory drugs, inhibits anti‐CD3 or IL‐2 driven proliferative responses of cloned human T‐cells. Furthermore, tenidap was found to inhibit IFN‐γproduction as well as the induction of mRNA encoding IFN‐γ or TNF‐α. The results indicate that tenidap may exert at least part of its anti‐inflammatory activity via inhibition of T‐cell function and cytokine production.