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Changes in lung volumes and airway resistance after exercise in asthmatic subjects.

Lung volumes and airway resistance were measured in a body Plethysmograph in 9 normal children and 7 patients with asthma at rest and after exercise by running. In the normal subjects, exercise resulted in minimal changes in lung volumes but some increase in airway resistance. The increases in lung volumes and airway resistance in the asthmatic subjects were much greater and highly significant. With administration of disodium cromoglycate to asthmatic patients 30 minutes before exercise, bronchoconstriction following exercise was completely prevented in 2 subjects and partially prevented in 3. In the other 2 patients, the duration of bronchoconstriction was shortened. In both normal and asthmatic subjects, specific airway conductance and maximal midexpiratory flow were more affected by the exercise than forced expiratory volume in one second and peak expiratory flow.