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Analytical Tools for Functional Connectivity: A New Review.

milliseconds). The authors suggest that this early increased functional connectivity of the amygdala to both frontal and temporal regions represents rapid, parallel processing within a distributed corticolimbic network. The report of Hesse et al is consistent with previous work suggesting that the amygdala is an important early encoder of information related to moral cognition and plays a critical role in complex cognitive processes that are affected by the salience of behavioral stimuli. The data support the notion that pathologically increased activity in the amygdala could result in the attribution of harmful intent to neutral stimuli and that disrupting this process could be beneficial to patients suffering from posttraumatic stress disorder. Further work in a greater number of subjects aimed at delineating a functional topography of behavior-specific neural dynamics within the amygdala would significantly inform efforts to develop this brain target for deep brain stimulation.