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Prospective Study To Investigate The Prevalence Of The 90 kDa Isoform Of Angiotensin Converting Enzyme In Vitória ‐ Brazil

Hypertension is considered a worldwide public health problem and identified as a risk factor for cardiovascular morbidity and mortality. The Renin Angiotensin System (RAS) has been a focus of interest of researchers in the area of hypertension both for the identification of its etiopathogenesis and for its treatment. In order to identify the components involved in the onset of hypertension and the participation of Angiotensin I Converting Enzyme (ACE) in this problem, the RAS has been the object of many studies. ACE has a great physiological importance for converting angiotensin I (Ang I) to angiotensin II (Ang II), a potent vasoconstrictor. Some papers suggest the association of ACE isoforms, especially the 90 kDa isoform, with hypertension. The aim of this study was to investigate the association between ACE isoforms and the presence of arterial hypertension in the second phase of the prospective study (MONICA Project) in the population of Vitória ‐ ES, Brazil.