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Role of Wnt pathway in medulloblastoma oncogenesis

To clarify the roles of Wnt pathway in medulloblastoma oncogenesis, immunohistochemical staining of β‐catenin and Wnt‐1 and genomic analyses of CTNNB1 (β‐catenin) and AXIN1 (axin 1) were examined in 23 sporadic cases. Accumulation of β‐catenin in tumor cells was immunohistochemically proven in 5 cases; 2 cases showed positive immunoreactivity for Wnt‐1 and another 2 showed mutation of either CTNNB1 or AXIN1. AXIN1 mutation was in exon 3, corresponding to GSK‐3β binding site and CTNNB1 mutation was in exon 3, corresponding to its phosphorylation site. Disruption of these proteins could result in upregulation of the Wnt signaling and accumulation of β‐catenin, followed by cell proliferation and medulloblastoma oncogenesis. © 2002 Wiley‐Liss, Inc.