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Childhood Pre‐B acute lymphoblastic leukemia and glutathione S‐transferase omega 1 and 2 polymorphisms

Acute lymphoblastic leukemia (ALL) is the most prevalent malignancy among children and makes up 23% of total childhood cancers worldwide. Pre‐B ALL is one of the most common ALLs, comprising about 80% of childhood cases. A variety of genes are involved in metabolizing carcinogens. These gene polymorphisms can result in less efficient or overly‐down metabolic pathways, which may contribute to the susceptibility to develop cancer. Glutathione S‐transferase omega (GSTO) is a new known class among GSTs superfamily. GSTO1 and GSTO2 polymorphisms have been reported to be related to several types of disease. We assessed the association between GSTO1 and GSTO2 polymorphisms and childhood pre‐B ALL risk in Iran.