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ACUTE CHANGES OF ARTERIAL STIFFNESS INDEXES WITH SALT OVERLOAD: PP.31.225

Introduction and Objective: Ambulatory arterial stiffness index (AASI) is a novel measure of large arterial stiffness, and digital volume pressure (DVP), measured by using photoplethysmography let us measure the shape of peripheral artery pressure waves also influenced by arterial stiffness. The aim of our study was to evaluate the changes of different arterial stiffnees indexes induced by salt overload, in salt sensitivity (SS) and salt resistant (SR) healthy people. Patients and Methods: Data from 17 living kidney donors were included in the present analyses. The subjects were placed on a low-salt diet during 7 days and on a high-salt diet during the following 7 days. On the last day of both periods,arterial stiffness measurement was performed using a photoplethysmograph (Micro Medical, UK). 24-hour ambulatory blood pressure monitoring (ABPM) was performed in both periods with an automated, noninvasive device. We evaluated stiffness index (SI) and reflection index (RI) from DVP and AASI and PP24 from ABPM. Results: There were 13 women and 4 men with a mean age of 48 ± 10 years (range 27 to 67 years). 47% were SS, with a mean age of 51,3 ± 11years vs 45,6 ± 10 years in SR (p = 0,16). SR people did not shown significant changes between low and high salt diet in AASI: 0,34 (0,32–0,43) vs 0,33 (0,29–0,39) and PP24: 36,1 (35–44,2) vs 38,8 (36,7–41,4); but they showed significant changes in SI: 10,3 ± 2 vs 8 ± 2 (p < 0,02) and RI: 70 ± 11 vs 64 ± 12 (p < 0,05). SS people did not show significant changes between low and high salt diet in none of the four indexes AASI: 0,37 ± 0,30 vs 0,53 ± 0,23; PP24: 38,8 ± 8 vs 44,3 ± 12; SI: 8,4 ± 2 vs 8,1 ± 1, RI: 64 ± 10 vs 59 ± 12. Conclusion: We did not observe significant changes in AASI and PP24 with salt overload in none of the two groups, DVP showed significant changes in SI and RI in salt resistant but we did not observe it in salt sensitivity healthy people.