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Impact of Dietary Restriction and Exercise on Dopamine Transporter Function in Male and Female Adolescent and Adult Rats

Eating disorders, including anorexia, are a major public health concern, compounded by a lack of effective treatments. They are complex illnesses and their etiology remains unclear, however, dysregulation of dopamine (DA) neurotransmission is a consistent finding. The DA transporter (DAT) terminates DA neurotransmission by high‐affinity uptake of DA into neurons and because of this, is a primary regulator of both the strength and duration of DA signaling. Surprisingly, however, few studies have investigated the relationship between DAT and eating disorders. We and others have shown that DAT activity is highly sensitive to diet. An important caveat of these studies is that they have been performed almost exclusively in adult, male rodents; however eating disorders are more prevalent in adolescents and more so in girls than boys. Here we use a modified version of the activity‐based anorexia (ABA) model to investigate the impact of age, gender, exercise and restricted food access on DAT function to gain insight into the potential role of aberrant DAT activity in eating disorders.