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Influence of ethionine on the ultrastructural morphology of the porcine hepatocyte.

In the present study the morphological alterations induced by ethionine poisoning in the porcine liver were examined by electron microscopy. It was found that the most prominent ultrastructural changes were: accumulation of fat drops in the cytoplasm, disappearance of polysomes, fragmentation and vesiculisation of the endoplasmic reticulum, altered glycogen distribution and mitochondrial swelling. These closely resembled the pathological changes found in rat parenchymal cells under the same circumstances. In addition, moreover fat deposits were found in the nucleoplasm. The microbodies showed an altered morphology.