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International symposium on energy metabolism and oxidative stress in liver pathophysiology

It is a great pleasure for me to introduce the Proceedings of the International Symposium on Energy Metabolism and Oxidative Stress in Liver Pathophysiology. The symposium was held in Tokyo, Japan on 16 and 17 December 2005. With the remarkable progress of molecular cell biology, the mechanisms related to the dysfunction of mitochondrial energy metabolism and those related to oxidative stress have been elucidated one by one. Nevertheless, many had been left unsolved. Along with rapid and steady progress in understanding the clinical feature of non-alcoholic steatohepatitis as well as alcoholic steatohepatitis, there has been dissemination of the concept of metabolic syndrome. In the field of hepatology in particular, I think that the significance of metabolic pathogenesis has been re-recognized. We believe that the symposium provided good opportunities to discuss liver disease and its pathophysiology from the viewpoints of energy metabolism in mitochondria and oxidative stress. We had more than 30 excellent invited speakers from around the world in this symposium, who gave us various perspectives on liver pathophysiology. We expect that the symposium will help your future research, and also help expand and strengthen our international cooperation and friendship in the future. On behalf of the Symposium Organizing Committee, I would like to express my appreciation to all the speakers and participants for their contributions, ending the symposium on a high note. I greatly appreciate Professor John J. Lemasters of University of North Carolina, Professor David A. Brenner, Dr Yoshiyuki Takei of Juntendo University and Dr Kenichi Ikejima of Juntendo University for their advice and support in organizing the symposium. doi:10.1111/j.1440-1746.2006.04637.x