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Piperacillin plus aztreonam for treatment of neutropenic fever

Background : A combination of beta‐lactam plus an aminoglycoside is the most frequently used regimen for febrile episodes in neutropenic cancer patients. However, aminoglycoside‐related toxicity occasionally makes this regimen difficult to use as the first‐line drug therapy. In the present study, we chose aztreonam as the alternative to aminoglycoside in combination with piperacillin for neutropenic fever in pediatric patients and we evaluated its effectiveness.