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THE INFLUENCE OF ANTIHYPERTENSIVE THERAPY ON 24-HOUR PARAMETERS OF ARTERIAL STIFFNESS MEASURED BY OSCILLOMETRIC DEVICE: PP.25.27

Objective: According to the recent data, the effect of ACE inhibitors on arterial stiffness is preferable in comparison with beta-blockers. The aim of our study was to investigate the effect of metoprolol (M) and enalapril (E) on different 24h parameters of arterial stiffness, using the oscillometric ambulatory blood pressure measurement (osABPM) device, with the function of QKD (Korotkoff Diastolic pressure delay) measurement and analysis of native oscillometric curves. Methods: 32 patients (mean age 55,1 ± 8,9 years; mean 24h systolic blood pressure (SBP)/diastolic BP(DBP) >135/85 mmHg) were enrolled into the randomized cross-over study. The doses of E were 5-10 mg, the doses of M - 100 mg o.d. The 24 h measurements were performed by the BPLab-3 (Nizhny Novgorod, Russia) device at the end of both control periods and courses of therapy. We analyzed 24h pulse transmission time (PTT), maximum rate of increase of arterial pressure (dP/dt max), oscillometric arterial stiffness index (ASI), and augmentation index (Aix). We used t-test for assessment of the value of the variables (no treatment vs. treatment). Results: During the follow-up period, mean 24h SBP levels (150,4 ± 1,7 for E and 149,4 ± 1,6 for M) were decreased to 130,6 ± 1,6 and 128,5 ± 1,6, respectively; p > 0,05). Baseline mean 24h pulse pressure (58,9 ± 1.4 and 56,7 ± 1,4) was decreased to 50,9 ± 1,4 and 48,1 ± 1,4, respectively (p > 0,05). The dynamics of the arterial stiffness variables is shown in Table1. Conclusions: According to our preliminary data, there is no significant difference in the effect of E and M on 24h parameters of arterial stiffness. The value of the specific oscillometric parameters (dP/dt) seems to be higher than the PTT value. Figure 1. No caption available.