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CD 200-mediated regulation of skin immunity.

Molecular interactions between CD200 and its receptors have been shown to suppress inflammatory responses and even induce peripheral immunological tolerance in selected tissues.Rosenblum et al (2004a,b) are the pioneers in studying the expression and function of CD200 in the skin. In this issue of the Journal of Investigative Dermatology (JID), the same group now reveals mRNA expression profiles of four putative CD200 receptor (CD200R) isoforms by murine epidermal cell subsets as well as functional abnormality of epidermal Langerhans cells in CD200-deficient mice and CD200-mediated immunomodulation of epidermal T cells. The new findings imply that CD200/CD200R-mediated intercellular communication among different epidermal cell subpopulations may play an important role in preventing undesired immune responses in the skin.