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PROCEEDINGS OF THE SIXTY‐FOURTH MEETING OF THE BRITISH NEUROPATHOLOGICAL SOCIETY HELD AT THE NATIONAL HOSPITAL, QUEEN SQUARE, LONDON, 13–14 JANUARY 1983

Albino animals and man show a reduced size of ipsilateral RGP, which correlates with the absence of retinal pigmentation. The heterozygous mouse (mi/-) shows fur spotting and slight reduction in retinal pigmentation, while the homozygous (milmi) shows pleotrophic effects, including micropthalmia and absence of pigmentation of the fur and retina. After unilateral enucleation in the heterozygous mouse (mi/-) there was no reduction in the ipsilateral component of the RGP, confirming other studies that the ipsilateral RGP is only reduced when there is significant diminution in retinal pigmentation (Lavail et al., 1978, J. Comp. Neurol. 182, 399). The homozygous mouse' (milmi) showed extensive bilateral degeneration of the RGP, more contralateral to the enucleation. The Fink-Heimer technique was applied to all three groups of animals (-/-, mi/and milmi) at 2, 4, 6, 8, 10 and 12 weeks of age. This identified the transitory period of degeneration in all groups of supernumerary RGP fibres at 2 weeks of age. In addition, in the homozygous mouse (milmi) persistent degeneration occurred at all stages examined which correlated with progressive shrinkage and calcification of the microphthalmic eye.