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OC26.07: Prenatal echocardiographic classification and prognostic evaluation strategy in fetal pulmonary atresia with intact ventricular septum

Objectives: Quantile score is a new reference system for prenatal diagnosis of fetal cardiovascular diseases. The study was to explore the new diagnostic and screening method in fetuses with tetralogy of Fallot (TOF) based on normal fetal q score data model. Methods: A total of 192 cases with TOF were collected and their echocardiographic examinations were retrospectively analysed. Q-score values of 48 fetal echocardiographic variables were calculated in each case. Forty-eight variables from 6272 normal fetal echocardiographic exams were used to determine the normal range of q score values. The core diagnostic variables of fetal TOF were obtained by statistical analysis in forward selection method and Naive Bayes classification, including the variables and combinations of variables within screening and diagnostic demand. Results: The four core diagnostic variables selected by statistical analysis were aortic diameter, pulmonary artery, inferior vena cava S wave. If the first three variables were used to diagnose fetal TOF, the area under the ROC curve is 0.90. If the diagnostic sensitivity of more than 90% is guaranteed, the above three parameters should be used together in the range of false positive rate ≤3%; in the false positive rate≤ 5% within the scope of the joint use of these three parameters can be achieved more than 95%. Conclusions: The diagnostic echo parameters acquired by medical big data statistical methods have higher diagnostic precision and the acquisition of core variables has the advantages of objectivity, facticity and intelligence.