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[Maturation of the pituitary-gonadal system in girls born at term with low birth weight].

Blood levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol and progesterone have been assayed in 92 girls of 10 to 17 years of age who were term low birthweights and in 114 girls of matched ages who had normal birthweights. The girls with perinatal complications were found to have an aberrant pituitary-gonadal status: an increased FSH and estradiol level in the pubertal phase, relatively early age of menarche, delayed maturation of steroid and ovulatory ovarian function, significant incidence of menstrual disorders. These abnormalities of reproductive maturation are likely to be associated with adverse factors of the antenatal period of ontogenesis.