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Hypomethylation of long interspersed nucleotide element‐1 in peripheral mononuclear cells of juvenile systemic lupus erythematosus patients in China

Methylation abnormalities in T lymphocytes have been reported to correlate with systemic lupus erythematosus (SLE). Previous studies identified hypomethylation in the promoter of several genes linked to SLE. Long interspersed nucleotide element‐1 (LINE‐1) constitutes 17–25% of the human genome, and LINE‐1 hypomethylation has been reported in SLE. Limited information is available regarding LINE‐1 methylation in juvenile SLE (JSLE).