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Synthesis and structure-activity studies on aliphatic carbamates and thiocarbamates toxic to scabies mites, Psoroptes spp. (Acari: Psoroptidae).

In laboratory tests, dialkyl carbamates of types ROC(O)NHR′, RSC(O)NHR′, and ROC(S)NHR′ were found to be extremely toxic to Psoroptes spp., including P. ovis (Hering), the common scabies mite of cattle and sheep. Fifty-six compounds of these three types were lethal to P. cuniculi (Delafond) at 0.001 % AI in a tea bag assay. Molecular length, and not the position of the functional group, determined toxicity. Those compounds also tested against P. ovis had approximately equal activity for both species. Testing on rabbits or cattle with scabies showed activity comparable to that of toxaphene, the commercial standard.