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Dopamine D2 receptor regulation of reactive oxygen species production via paraoxonase 2

An intact dopaminergic system is necessary to maintain normal blood pressure. We have reported that D2 dopamine receptor (D2R) regulates renal reactive oxygen species (ROS) production and that altered D2R function results in ROS‐dependent hypertension. Paraoxonase 2 (PON2) belongs to the paraoxonase gene family that is expressed in various tissues including the kidney and protects against cellular oxidative stress.