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A brief history of RNAi: the silence of the genes

The use of the RNA interference (RNAi) pathway to eliminate gene products has greatly facilitated the understanding of gene function. Behind this remarkable pathway is an intricate network of proteins that ensures the degradation of the target mRNA. In this review, we explore the history of RNAi as well as highlighting recent discoveries.—Sen, G. L., Blau, H. M. A brief history of RNAi: the silence of the genes. FASEB J. 20, 1293–1299 (2006)