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NEUROLOGICAL DISORDERS AND OTHER KNOWN PATHOLOGIES DUE TO NITRIC OXIDE AND SUPEROXIDE CYCLING DISTURBANCES

The article discusses the mechanisms of development of a typical pathological process, oxi-dative and nitrosative stress, which underlie many neurological disorders and other known diseases. Cycles of nitric oxide and superoxide anion-radical under physiological conditions do not allow the development of pathological changes in the vital systems of the body. How-ever, when they are damaged, the main regulatory mechanisms are violated, and “dysregula-tory pathology” sets in (G.N. Kryzhanovsky), due to the formation of extremely active com-pounds - nitrogen dioxide (NO2), OH-radicals and peroxynitrites, which, after protonation, decompose again with the formation of radicals NO2 and OH radicals. It is hypothesized that it is these mechanisms that disrupt the cycles of nitric oxide and the superoxide anion radical that underlie the development of a typical pathological process.