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Effect of in vitro non‐enzymatic glycosylation of human skin collagen on susceptibility to collagenase digestion

Abstract. The effect of glycosylation on susceptibility of skin collagen to collagenase digestion was studied in a skin sample obtained at autopsy from the interscapular region of a 24 year old white male who had died of an acute illness and who had no history of diabetes. Homogenous suspensions of insoluble collagen were prepared, and were incubated in 50 mmol 1‐1 dextrose at pH 7·35 and 37°C for 7 days. Non‐enzymatic glycosylation measured by the weak acid hydrolysis/thiobarbituric acid method increased from 13·1 ± 1·0 (n= 5) to 45·2 ± 5·5 (n= 8) nmol fructose per 10 mg collagen (P < 0·001).