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Effects of sex and dose of inoculum on the antibody response of mice to Tahyna virus (Bunyaviridae).

Six weeks old random bred ICR mice were inoculated intraperitoneally with two different doses of Tahyna virus (125 and 12 500 smicLD50). The higher dose caused marked involvement of the central nervous system in a few animals and induced high virus neutralization (VN) antibody titres in more animals than the lower dose. The dose of inoculum had no effect on the height of VN antibody titre in mice with antibody titres > 64. The proportion of mice with VN antibody titres > 64 was 72.7% in males and 56.8% in females. Male mice thus appeared to be somewhat more susceptible to Tahyna virus infection than female mice.