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Effect of alpha-tocopherol on doxorubicin-induced changes in rat heart lysosomal enzymes.

Effect of doxorubicin on heart lysosomes were studied in rats with or without the administration of alpha-tocopherol. Rats were treated with doxorubicin (2.5 mg/kg body wt, iv) once a week for 8 weeks. alpha-tocopherol (400 mg/kg body wt) was co-administered orally for 2 months. Activities of acid phosphatase, beta-D-glucuronidase, cathepsin-D and beta-D-galactosidase were decreased in heart lysosomes but increased significantly in serum. A significant increase in lysosomal lipid peroxide level was noted. alpha-tocopherol co-administration reduced the lipid peroxide level as well as maintained the above mentioned enzyme activities.