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Glucocorticosteroids rapidly inhibit allergen‐induced expression of E‐selectin in vitro in a mucosal model of allergic rhinitis

Background: Transendothelial migration of cells to sites of inflammation is a hallmark of the allergic reaction. The adhesion cascade involves the initial expression of the adhesion molecule E‐selectin on endothelial cells. The aim of the study was to determine the efficacy of a 30‐min preincubation of the glucocorticosteroids (GCS) fluticasone, prednisolone, and fluocortin butyl on allergen‐ and interleukin (IL)‐1β‐induced E‐selectin expression in allergic rhinitis.