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Study on the Joint Toxicity of Multi-component Mixtures of Quaternary Ammonium Compounds

Pollutants generally exist as mixtures in the environment. Their cumulative toxicity and toxicity interactions are potential risks. Therefore, this study aimed to examine the variation of joint toxicity of a multi-component mixture system, which consisted of six common quaternary ammonium salt surfactants in the environment, on Vibrio qinghaiensis sp.-Q67 (Q67). Vibrio qinghaiensis sp. -Q67 (Vqin-Q67) is a freshwater luminescent bacterium that continuously emits blue-green light (485 nm). The bacterium has been widely used for detecting toxic contaminants. In the mixture system, the luminescent toxicity of each component of the mixture to Q67 was determined by the microplate toxicity analysis method, and the toxicity interaction of the mixture was determined by the toxicity unit method (TU). The combined toxicity of the mixture system was investigated from four aspects, including the number of components, key components, concentration (toxicity) ratio, and exposure time. The results showed that the combined toxic effect of the same mixture system tends to be an additive effect with the increase of the number of components. The combined toxicity of the mixture system was close to that of the key components. Antagonism was presented in the equal toxicity mixture, while synergism was presented in the non-equal toxicity mixture. The combined toxic effect of the multi-component mixture system was not only related to the concentration of the pollutant but also related to the exposure time of the pollutant.
