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Ultrastructure of Anterior Lens Capsule and Epithelium in High-Myopic Cataracts


 BACKGROUND: The mechanism of high-myopic cataract (HMC) is not fully understood yet. The ultrastructure of anterior lens capsule (aLC) and lens epithelial cells (LECs) may provide some clues to this issue.METHODS: Capsulorhexis samples from 10 eyes with HMC and 10 eyes with age-related cataract (ARC) were analyzed for morphologic characteristics using transmission electron microscopy (TEM).RESULTS: Several common pathologic disorders of LECs, including pleomorphic cellular structure, extensive intracellular vacuoles, swollen organelles, degeneration and necrotic lesions, could be observed in both HMC group and ARC group, to a similar extent. Specimens of HMC group disclosed remarkable extracellular spaces, interdigitation of LECs as well as protuberances of aLC towards LECs. CONCLUSIONS: The ultrastructure of aLC and LECs in HMC demonstrated some specific pathologic disorders in comparison with ARC, which might play a role in the formation of cataract in high myopes.