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Dual role of junctin in the regulation of ryanodine receptors and calcium release in cardiac ventricular myocytes

Non‐technical summary  Each heartbeat is accompanied by the coordinated release of calcium ions into cardiac cells through ryanodine receptors, which span the membrane of the sarcoplasmic reticulum. We show that an intra‐sarcoplasmic reticulum protein, junctin, interacts with ryanodine receptor channels and appears to activate them when calcium inside the sarcoplasmic reticulum is low. Conversely, junctin appears to act as an inhibitor of ryanodine receptors when calcium inside the sarcoplasmic reticulum is high. Knowledge of how junctin interacts with ryanodine receptors helps us to understand how calcium within the sarcoplasmic reticulum helps to regulate ryanodine receptor activity in normal hearts and also helps us to understand why junctin is decreased in patients diagnosed with certain forms of heart failure.