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SIMULTANEOUS ANALYSIS OF EZETIMIBE AND ROSUVASTATIN BY UV SPECTROPHOTOMETRIC METHOD

A novel UV spectrophotometric method has been developed for the simultaneous estimation of ezetimibe and rosuvastatin in combined dosage form. Method is based on simultaneous equations method. The wavelengths selected for analysis were λmax of ezetimibe: 231.2 nm and λmax of rosuvastatin: 242 nm. Beer’s law was obeyed in the concentration range 2-40 µg mL-1 for ezetimibe and rosuvastatin, with correlation coefficient (r2) greater than 0.990. Validation of the developed method was as per ICH guidelines. The % assays of ezetimibe and rosuvastatin in tablet formulation complied with acceptance criteria. The developed method thus serves as a powerful quality control tool for simultaneous analysis of the drugs in bulk and in formulation by UV spectroscopy.