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Macrophage‐Specific Phenotypes Direct Fibroblast Expression of Matrix Metallopeptidases

During wound repair, fibroblasts secrete abundant extracellular matrix (ECM) components and participate in remodeling of the provisional ECM. Macrophages and other immune cells play a critical role in all stages of wound healing and are primarily responsible for directing ECM‐producing cells into the wound site to replace it with the new scar tissue. Classically activated macrophages, M1M□, contribute to inflammation early on, whereas alternatively activated macrophages, M2M□, secrete ECM‐degrading enzymes, including matrix metallopeptidases (MMPs), during resolution. Macrophages instruct fibroblast activities, largely via secreted factors. However, the differential effects of M1M□vs M2M□ on fibroblasts remains unknown. This study is designed to evaluate the various roles of differentially polarized macrophages through secreted factors on fibroblast activities that relate to wound resolution.