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[Idiopathic osteoporosis at an early age].

Two males, aged 33, with progressive pains in the spine are described as well as with high degree osteoporosis, compressive fractures of several vertebrae and a rapid evolution of the changes. The values of serum calcium and phosphorus as well as alkaline phosphatase proved to be normal. Excretion of calcium and hydroxyproline in urine were also normal, whereas phosphorus excretion was increased. It was concluded that the case concerned idiopathic osteoporosis in early age, with unknown pathogenesis. The carried out treatment with vit. D and sodium fluoride in the course of one year impeded the evolution of the bone changes in the second patient, while the anabolizing treatment in the first patient was without any effect.