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Imipramine and methylphenidate in hyperactive children.

SUMMARY 
 
A double blind, placebo controlled, crossover study using methylphenidate as a standard and two doses of imipramine was carried out in 30 hyperactive children. Particular emphasis was placed upon imipramine's action on cognitive function, physiological function, self-esteem, and dosage effects. There were positive effects on learning, motor performance, and social behavior, but self-esteem showed only minimal fluctuations. Certain physiological measures (in particular, cardiovascular) were adversely affected by the drugs. There were few statistically significant dose effects but, in general, the changes suggested that the lower dose resulted in less motor tremor and slightly superior clinical response. The effect of imipramine was basically similar to that of methylphenidate suggesting a stimulant-like action. In contrast to other studies, imipramine was, in the short term, clinically more effective than methylphenidate but, as in other investigations, side effects were greater.