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Secrets of Drug Resistance in NSCLC Exposed by New Molecular Definition of EMT

Non–small cell lung carcinoma (NSCLC) metastasis and drug resistance has been associated with epithelial-to-mesenchymal transition (EMT). This study reports the development of a robust gene expression signature of EMT in NSCLC and reveals new insights into the key molecular events that underlie EMT and drug resistance in NSCLC. Clin Cancer Res; 19(1); 3–5. ©2012 AACR.