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AGE-ASSOCIATED FACTORS CONTRIBUTING TO OBSTACLE NEGOTIATION ABILITIES: NOT ALL IS AS EXPECTED

We demonstrated the use of factor analysis to link dif-fering cognitive batteries over ARIC-NCS visits to common metrics representing general and domain-specific cognition. We used 23 years of data from the Atherosclerosis Risk in Communities Study (ARIC-NCS) (N=14,252). Using generalized estimating equations, we compared associations of diabetes with cognitive change using general and domain-specific factor scores vs. z- scores. Factor scores provided stronger associations with diabetes at the expense of greater variability around estimates (e.g., for executive functioning, -0.065 SD units/year, SE=0.015, vs -0.057 SD units/year, among older adults (50.0 ± 40.4%), as compared to young adults (100 ± 0.0%). For all subjects, the effect of unex-pected obstacle height on SR was opposite to our hypothe-sis; surprisingly, SR was lower when the obstacle height was higher (p<0.001). For young adults, SR was related to ART (p=0.02), however, for the older adults, SR was not related to ART. Among the older adults, SR was correlated with stride length (r s =0.42, p=0.039) and Trail Making Test B (r s =-0.38, p=0.055). These findings provide new insights into the ability of older adults to successfully negotiate obstacles and help to better understand the mechanisms that underlie this everyday skill. The UAB Life-Space Assessment (LSA) is a validated patient-reported outcome to measure community mobility and social participation. We have previously shown that LSA predicts adverse health outcomes including mortality, nurs-ing home admission, and cognitive decline, but the role of life-space in healthcare utilization among older adults in general is not known. Participants (N=400) were drawn from the UAB Study of Aging II, a longitudinal study of commu-nity-dwelling adults age ≥75 identifying predictors of mobility decline. LSA scores at each monthly follow-up interview were used to predict emergency department (ED) visits and hospitalizations over the next 30 days using generalized estimating equations, adjusting for baseline age, race, gender, education, Charlson comorbidity In multivariable models adjusted for age, sex, race, education, mobility diffi-culty, peripheral arterial disease, and number of joint pain sites, CAS scores were associated with shorter SRT (p=0.02) and CRT (p=0.01). The association persisted but was weaker after further adjusting for gait speed (SRT, p=0.05; CRT, p=0.03). Adjustment for vision impairment did not alter the relationship between CAS and reaction time. These results show that participation in cognitively stimulating activities is associated with shorter foot reaction time. Further research is needed to determine whether participation in cognitive activities could reduce fall risk in older adults.