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Regulatory Networks Controlling Vibrio cholerae Virulence Gene Expression

Cholera, a severe disease caused by Vibrio cholerae bacteria, has had a central role in the history of infectious disease research. The cholera studies of John Snow and Robert Koch, among many others, largely gave birth to modern epidemiology and microbiology. Despite its long history as a research target, cholera continues to afflict approximately 5 million people each year and remains an important public health problem in many areas of the globe. Here we review the current knowledge of the complex regulatory network used by V. cholerae to control expression of its virulence determinants.