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Multi-modality photoacoustic/ultrasound imaging based on a commercial ultrasound platform.

Multimodal imaging takes advantage of each modality and has become a recent trend in the field of biomedical imaging. In this Letter, we develop and evaluate an integrated multi-modality imaging system combining photoacoustic computed tomography, optical resolution photoacoustic microscopy, brightness mode, and power Doppler ultrasound imaging on a commercial ultrasonographic platform. Using different imaging modalities enables the hybrid system to recover dense vascular networks and hemodynamic and morphological variations in both superficial and deep tissues. To evaluate the performance and illustrate the advantages of this system, we carried out both phantom and in vivo experiments. In addition to the complementary tissue information offered by different imaging modalities, the use of a commercial ultrasound platform shows the feasibility of the proposed method for future clinical translation.