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Evoked potentials in cerebral ischemia.

THREE PAPERS in this issue of Stroke highlight the use of short latency somatosensory evoked potentials (SEPs) to quantify neuronal dysfunction in models of cerebral ischemia. These investigators, and others, have taken advantage of two special properties of SEPs, and "early" EPs in general: a relative resistance to general anesthesia, and an approximate localization of cortical SEP generators to the somatosensory cortex, (or the ectosylvian gyrus in animals), allowing correlation of electrical activity with local CBF. Unfortunately, this literature is arduous reading, even for the initiated. Because SEPs are likely to be used more often to validate models of ischemia and to study stroke patients, it is important to understand the technical difficulties, to appreciate the care required for a dependable result, and to recognize the limitations on interpretation, especially in ischemia.