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Synaptic plasticity studies and their applicability in mouse models of neurodegenerative diseases

During the past few years, there have been many important contributions to the better understanding of the different types of memory and the putative neural structures that generate them. Moreover, various studies on neurodegenerative diseases in human beings have added useful information about learning and memory formation, and about their loss in patients with these disabling diseases. The development of sophisticated pharmacogenetic tools applied to mouse models, reproducing different types of neurodegenerative disease or, at least, some of their main symptoms, has turned out to be extremely useful for the further development of contemporary neuroscience. In addition, ingenious behavioral and electrophysiological approaches have been developed to study the activity-dependent changes in synaptic strength during learning and memory processes in the best possible way — that is, in the alert behaving animal. Collected data from these numerous studies have enabled us to know more about the role of many different molecular components integrating the synaptic cleft, and to draw some conclusions about the concordance between in vitro and in vivo recorded data, and the generalization of the results to other types of learning and/or brain-related structures. As described here, changes in synaptic strength studied in key neural synapses during learning and memory processes in genetically manipulated mice can represent an interesting and powerful approach to the better understanding of neural processes underlying the acquisition of new motor and cognitive abilities and how they are affected by different human diseases involving the neural tissue.