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AB1378-HPR EFFECT OF CLINICAL CHARACTERISTICS, HABITS, PHYSICAL ACTIVITY LEVELS AND FUNCTIONAL CAPACITY ON QUALITY OF LIFE IN SYSTEMIC SCLEROSIS PATIENTS

Background In patients with Systemic sclerosis (SSc), many factors such as inactivity, smoking, gastrointestinal system involvement are reported to have an adverse effect on overall health related quality of life, and quality of life is in line with the prognosis of the disease (1,2). Objectives The aim of this study was to investigate the effect of clinical characteristics, habits, physical activity levels and functional capacity of patients with SSc on quality of life. Methods Twenty-tree SSc patients were included in the study. The ages of patients, the amount of cigarette consumption, duration of diagnosis and body mass indexes (BMI) were questioned and recorded. Functional capacities of patients were measured by 6 Minute Walking Test (6MWT). Physical activity levels of patients were calculated using the International Physical Activity Questionnaire (IPAQ; using metabolic equivalent-MET). Quality of life was evaluated by the short form SF-36 quality of life questionnaire(SF-36 QoLQ). The SF-36 questionnaire was evaluated as two sub-scales, physical and mental. Results The mean age of the patients was 51.0011.10 years and the duration of diagnosis was 7.604.80 years, BMI was 26.606.37 kg/m2 and amount of cigarette consumption was 6.023.30 packetyears. The mean physical activity levels (IPAQ) were 281.6860.45 MET, 6MWT distance were 435.3980.45 m, SF-36 QoLQ-physical were 32.4813.42 and SF-36 QoLQ-mental were 38.5611.42 score. It was found that there was a significant correlation between SF-36 QoLQ-physical and BMI (p =0.043, r =-0.426), 6DWT (p <0.001, r= 0.737) and IPAQ (p =0.001, r = 0.647). There was a significant correlation between the SF-36 QoLQ-mental and 6MWT (p=0.020, r = 0.483) and IPAQ (p =0.002, r = 0.614). Conclusion Reduced levels of physical activity in SSc patients affect functional capacity. Reduced physical activity level and functional capacity decrease the quality of life of patients related to both physical and mental health. Physical health related quality of life of patients is negatively affected by the increase in BMI. Functional capacity, clinical characteristics, habits and physical activity levels should be evaluated and improved in treatment programs aimed at improving the overall health-related quality of life of patients. References [1] Turesson, C., & Matteson, E. L. (2007). Cardiovascular risk factors, fitness and physical activity in rheumatic diseases. Current Opinion in Rheumatology, 19(2), 190196. [2] Hudson, M., Thombs, B. D., Steele, R., Panopalis, P., Newton, E., Baron, M., & Canadian Scleroderma Research Group (2009). Health-related quality of life in systemic sclerosis: A systematicreview.ArthritisandRheumatism,61(8),11121120. https://doi.org/10.1002/art.24676 Disclosure of Interests None declared