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Effects of sevoflurane on QT interval in a patient with congenital long QT syndrome.

THE inhaled anesthetics enflurane, halothane, and isoflurane prolong the electrocardiographic QT interval in healthy patients. 1 In patients with idiopathic long QT syndrome, however, cardiac arrest and death during halothane anesthesia, 2 absence of QT interval change during enflurane administration, 3 and shortening of QT interval during isoflurane anesthesia 4 suggest that generalizations from healthy patients to patients with long QT syndromes are unjustified. Similarly, thiopental prolongs QT interval in healthy patients 5 but had no effect in patients with long QT syndrome. 6 We recently anesthetized a young woman with idiopathic long QT syndrome. We report the effects of sevoflurane on the QT interval in this patient.