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In Silico Studies, Comparative Synthesis and Antibacterial Activity of Some Imine Derivatives of Isonicotinic Hydrazide

The biological activity of schiff base cut across a range of activities, it is therefore called a versatile Pharmacophore [1]. One of the major activity or the most reported activity of schiff bases is their antibacterial activity [1,2]. Some scholars have also synthesized some analogues of isoniazid imines and tested them against many pathogenic bacteria [3-6]. Another prominent research on the computational studies of imines is that of isoniazid – ketoprofen co-drug imine [7].