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[Cross infection of guinea pigs with different pneumococcal serotypes in the presence of the carrier state].

The possibility of the pneumococcal cross infection of guinea pigs in experimental conditions, the time course of the distribution of pneumococci in their organs, and the duration, within the time limits of the experiment, of persistence of the given infective agent were studied. Normal animals placed in the same room with infected ones were shown to become the carriers of definite pneumococcal serotypes. As a result, these studies revealed that nasopharyngeal carriership and infection of different organs were not directly interrelated and the method of infection of guinea pigs did not influence the time course of distribution of pneumococci in their organs. The data on the duration of persistence of the infective agent, as well as on the importance of this phenomenon for determination of the relationship between pneumococcal carriership and disease, are presented.