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[Comparative study of expressions of P16 protein in patients suffered from non-small-cell-lung-cancer of Xuanwei and Kunming district].

OBJECTIVE
To study the effect and function of P16 protein during the development of lung cancer, in order to explore the differences of expression of P16 protein in non-small cell lung cancer (NSCLC) between Xuanwei and Kunming district.


METHODS
45 patients with NSCLC from Xuanwei and 45 patients from Kunming,18 patients from pneumatocele who underwent radical resection were collected. Immunohistochemical staining were used to analyze the expressions of P16 protein in paraffin-embedded tissues from these 90 residing patients with lung cancer.


RESULTS
45 cases with lung cancer were negative for P16 protein expression, total loss expression rates were 41.7% (45/108). Loss expression rates of Xuanwei,Kunming and pneumatocele were 57.8% (26/45), 37.8% (17/45), 11.1% (2/18), respectively. In comparition the loss expression of P16 protein in clinicopathologic characteristics between the two groups, there were some statistically significant differences in the loss expression rate of P16 (P < 0.05): the loss expression rate of P16 in cases with stage I, adenocarcinoma and stage T2 in Xuanwei were more higher than those in Kunming; the loss expression rates of P16 in Xuanwei and Kungming were more higher than those in pneumatocele respectively.


CONCLUSION
Loss expression rates of P16 protein in the early stage and adenocarcinoma in Xuanwei lung cancer group were significant difference compared with in Kunming lung cancer group.