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Downregulation of central angiotensin II is involved in improvement of exercise training on cardiovascular activity in hypertensive rats

Exercise training (ExT) improves the cardiovascular activity in hypertension. Increase in central angiotensin II (Ang II) is a major contributor to cardiovascular activity in hypertension. The objective of the present study was to determine the role of central Ang II signaling in mediating the improvement of ExT on cardiovascular activity in spontaneously hypertensive rat (SHR). Following 12‐week low‐intensity ExT, the basal blood pressure was significantly decreased in SHR+ExT than in SHR. Central infusion of Ang II or the Ang II antagonist Sarthran produces the lower changes in blood pressure and sympathetic activity in the SHR+ExT than SHR group. Expression (mRNA) and bioactivity of angiotensin‐converting enzyme in the nucleus of solitary tract (NTS) was significantly upregulated in SHR compared with WKY, which was normalized by ExT. The concentration of Ang II was also decreased in SHR+ExT compared with SHR. In conclusion, the current data suggest that, in hypertension, ExT significantly improves the cardiovascular activity evoked by Ang II signaling, at least at the level of the NTS. This work was supported by the Shanghai Pujiang Program (09PJ1400100) and NSFC (30971061 and 81070214).