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TRIGLYCERIDES-GLUCOSE INDEX: A NEW PREDICTOR OF INCREASED ARTERIAL STIFFNESS. RESULTS FROM SEPHAR III – BRISIGHELLA HEART STUDY POOLING PROJECT

Objective: To analyse the use of Triglycerides-Glucose Index (TGI) – an easy index of insulin-sensitivity, as a predictor of increased arterial stiffness. Figure. No caption available. Design and method: A pooling project combining SEPHAR III's (Study for the Evaluation of Prevalence of Hypertension and cardiovascular risk among the Adult population of Roumania III) and Brisighella Heart Study's databases was carried out selecting all subjects with common variables available and excluding frankly diabetic subjects and subjects with sever CKD, resulted in a very large database of 2903 adult subjects (52.5% females). Arterial stiffness was evaluated by aortic PWV values. TGI was calculated as serum triglycerides to fasting plasma glucose ration (mmol/L). Variables included in the multiple linear regression analysis, having PWVAo as the target variable, were: age, smoking habit, sedentary, family history of premature CVD, SBP, DBP, HR, total cholesterol (TC), LDLcholesterol, HDLcholesterol, serum uric acid (SUA), eGFR and TGI. Results: The results of the descriptive analysis of the target variables are detailed in Table 1. Multiple linear regression analysis validated TGI as predictor of increased arterial stiffness in a model that includes also age, SBP, DBP, HR, LDLcholesterol and serum uric acid, irrespective of the gender (Table 2). Conclusions: Although having some limitation arising from the pooling design, our results offers support that Triglyceride-Glucose Index (an easy index of insulin-sensitivity, already demonstrated to be a good predictor of IMT) could serve as a predictor for increased arterial stiffness in our large sample.