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Development of the drug fibronectin and substantiation of its use to stimulate corneal healing

The urgency of the search for remedies accelerating corneal healing after its accidental and surgical injuries is obvious. In recent years, along with physical factors, some natural and synthetic substances, fibronectin turned out to be among the most promising therapeutic agents. It is an adhesive protein of connective tissue involved in cell attachment to fibrillar substrates, formation of collagen fibers and intercellular substance. Fibronectin and its fragments have chemotactic activity and can accelerate phagocytosis reactions by macrophages and neutrophils, acting as a non-specific opsonin against many exo- and endogenous pathological microparticles. One form of this protein, called plasma fibronectin, is present in blood and has many biological properties in common with tissue fibronectin.