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Intra‐uterine insemination with prepared sperm vs. unprepared first split ejaculates. A randomized study

Summary. In this randomized prospective study, we determined the conception rate following intra‐uterine insemination with washed and prepared sperm, or with the first portion of a split ejaculate, in couples with longstanding male (n = 27, 70 treatment cycles) or cervical infertility (n = 14, 29 treatment cycles). Folliculogenesis and ovulation were induced by human menopausal gonadotropin and human chorionic gonadotropin. Significantly more couples conceived in the male infertility group following intra‐uterine insemination with washed sperm, than after intrauterine insemination with split ejaculate (9 vs. 2; P<0.05), while no difference in pregnancy rate (2 vs. 2) was found by the two intra‐uterine insemination methods in the cervical infertility group.