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Once nightly sustained release theophylline in elderly subjects.

A recent paper (Steffensen & Pedersen, 1986) has suggested that once nightly sustained release theophylline therapy (Uniphyllin, Napp Laboratories) produces 'very reliable' absorption profiles in adults, though demonstrates unpredictable absorption in children. Our clinical impressions of this product in elderly patients are that absorption is not very reliable, and we present some data to support this contention. Indeed the data from Steffensen & Pedersen (1986) show a wide range of Cmax and tmax after nocturnal administration despite an 8 h fast pre dose, and a 4 h fast post dose. This situation is unlikely to arise in clinical practice and we have attempted to