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Contribution of Various Dietary Constituents to the Acid Base Status: Interest of Animal Models of Latent Metabolic Acidosis

Animal models of metabolic acidosis are generally based on drastic treatments and are poorly suitable as mod- els of latent metabolic acidosis (LMA). Specific rodent diets have been evaluated as LMA models, together with their re- sponsiveness to dietary alkalinizing factors. Using this model, the possibility to obtain LMA states with moderate levels of protein intake was identified, pointing to the critical role of anions in the mineral moiety of the diet. The potential role of large intestine fermentations to acid-base control has also been examined with this model.