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5-azacytidine-induced decrease in the frequency of Barr body in human fibroblasts.

5-azacytidine-treated human fibroblasts exhibit a significant decrease in the frequencies of Barr body + cells as compared to nontreated cultures. This presumably indicates that 5-azacytidine can induce a change in the degree of condensation of the Barr body. It is suggested that the state of chromatin condensation of the Barr body may be related to the reactivation process by 5-azacytidine of gene loci in the inactive X .