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Reparative effect of super active platelet lysate combined with allogeneic bone for large bone defects.

BACKGROUND
In clinical practice, autologous bone transplantation is usually used to treat large-scale bone defects. However, autologous bone can cause complications such as secondary injury to patients, the scarcity of autografts. In this study, the study of using super active platelet lysate (sPL) and allogeneic bone to treat the 15 mm long bone defect in right radius of New Zealand white rabbits, and provide an experimental basis for the next step of bone defect treatment.


METHODS
The critical-size defect of New Zealand white rabbits was made and divided into three groups: autologous bone group, allogeneic bone group and sPL group. They were euthanized 1 month, 2 months and 3 months after the operation. perform imaging and histological observation on the repair of bone defect area.


RESULTS
The results showed that there were varying degrees of new bone in the bone defect. CT data showed that the bone defect repair rate and new bone mass in each group increased month by month (P <0.05). Bone tissue (BV) and bone tissue to the total volume (BV/TV, %) in the sPL group> allogeneic bone group, autologous bone group > allogeneic bone group, with statistical significance (P <0.05). Compared with the allogeneic bone group, the sPL group can significantly promote the healing of bone defects, enhance the bone density after fracture healing. The repair effect after three months was similar to that of the autogenous bone group.


CONCLUSIONS
The use of allogeneic bone and sPL therapy may become part of a comprehensive strategy for tissue engineering to treat bone defects.