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Correlation between Musashi‐1 and c‐hairy‐1 expression and cell proliferation activity in the developing intestine and stomach of both chicken and mouse

Musashi‐1 (Msi‐1) is an RNA‐binding protein that plays key roles in the maintenance of neural stem cell states and in their differentiation into neural cells. Msi‐1 has also been proposed as a candidate marker gene of mammalian intestinal stem cells and their immediate lineages. In this study, we examined Msi‐1 expression in the small intestine and the stomach of both chicken and mouse during embryonic, fetal and postnatal development. In addition, we analyzed the expression of c‐hairy‐1, a chicken homologue of mouse Hes1, and assessed the proliferative activity of the cells expressing both of these factors. Significantly, during the development of these digestive organs in both species Msi‐1 expression showed dynamic changes, suggesting that it is important for digestive organ development, particularly for epithelial differentiation. Based on our observations of the expression patterns of Msi‐1 and c‐hairy‐1 in the adult small intestine, we speculate that Msi‐1 is also a stem cell marker of the chicken small intestinal epithelium.