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A microelectronic approach to identifying and modeling biological noise

One issue of synthetic biology concerns the ability to predict the functioning of a new biosystem, right from the design stage. To do so, many models are developed. This paper focuses on the phenomenon of biological noise, which is actually not integrated in the standard models. This paper describes the different biological noises and draws a comparison between them and microelectronic noises. The developed models are presented and their addition to standard ODE equations is illustrated on two systems widely used in synthetic biology: the protein synthesis and an oscillator.