{'fraction_non_alphanumeric': 0.02102496714848883, 'fraction_numerical': 0.015111695137976347, 'mean_word_length': 5.0436507936507935, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 1, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Maternal Exposure to Oxidized Soybean Oil Impairs Placental Development by Modulating Nutrient Transporters In A Rat Model.

SCOPE
As an exogenous food contaminant, dietary oxidized lipid impairs growth and development, trigger chronic diseases in humans or animals. This study explores the effects of soybean oil with different oxidative degree on the placental injury of gestational rats.


METHOD AND RESULTS
Thirty-two female adult rats were randomly assigned to 4 groups. The control group was fed the purified diet with fresh soybean oil (FSO), and the treatment groups were fed purified diets with lipid content replaced by oxidized soybean oil (OSO) at 200, 400 and 800 mEqO2 /kg from conception until delivery. On day 20 of gestation, OSO decreased placental and embryonic weights as the oxidative degree increased linearly and quadratically. The expression of Bax showed a linear increase, and Bcl-2 decreased as the oxidative degree increased. The expression of Fosl1 and Esx1 were linearly and quadratically decreased in OSO-treated groups than FSO group. OSO decreased the level of IL-10 but increased expression of IL-1β in placenta and plasma. OSO remarkably upregulated levels of Fatp1 and Glut1 and decreased expression of Snat2 and Glut3.


CONCLUSION
OSO aggravated placental injury by modulating nutrient transporters and apoptosis-related genes, impeded placental growth and development, and ultimately lead to the decrease of fetal weight. This article is protected by copyright. All rights reserved.