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EFFECT OF RETINOL ON MURINE EPIDERMAL DENDRITIC CELLS

Numerous immunoregulatory activities have been attributed to retinoids. The present study examined the effect of a single application of retinol (RO) on immunocompetent cells in murine epidermis. The inner epidermis of the left ear of C57/BL6J mice was painted with RO (50 ug/ml) in ethanol, while the right (control) ear received ethanol alone. Mice were sacrified at 0,12,24,36 or 48 hours, and epithelial sheets of the treated areas prepared. Two cell populations were detected using enzyme histochemistry and indirect immunofluorescence: Langerhans cells (ATPase+, Ia+), and cells expressing Thy 1.2 antigen (ATPase‐, la‐). In all cases ATPase+ cells were more numerous that Ia+ cells, however, neither RO nor alcohol treatment modulated la+or ATPase+ expression on Langerhans cells. In contrast, R O treatment increased the number of Thy 1.2+ cells detected at 12 and 24 hr post‐treatment when compared to baseline and alcohol controls. These results indicate that retinol is capable of modulating antigen expression on murine dendritic cells in vivo.