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Regional distribution of Renin/Prorenin receptor (RPR) in heart from healthy pregnant and pregnancy‐induced hypertensive rats

The renin‐angiotensin system (RAS) has become more complex with new components with cardiovascular functions. Renin/Prorenin receptor (RPR) is an important component of the renin‐angiotensin system. Its role during normal pregnancy and pregnancy‐induced hypertension (PIH) is not elucidated. The aim of this work was to study the distribution of RPR in heart during normal pregnancy and PIH in the rat. We used a subrenal aorctic coarctation (SRAC) model in female Wistar rats as an experimental model of PIH. Heart was weighted and auricular, septum and ventricular tissue samples were homogenized and immunoblotted using an Anti‐RPR antibody. We also measured gene expression by real time PCR. We found basal expression of RPR in control, non‐pregnant sham rats. We also found higher expression of both, gene and protein in pregnant rats compared to control rats. Moreover, in PIH we observed a consistent increase in expression of both, protein and gene, except in ventricular tissue, where only protein was increased. These findings indicate that RPR might play an important role in cardiac function and a probable role in the pathophysiology of PIH. Supported by SIP‐IPN 20100012 and 20101460 grants.