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[Comparative characteristics of lipid components of gallbladder and liver bile fractions in children with chronic cholecystitis].

In the course of this research we studied indices of lipid components--neutral lipids, phospholipids of biliary and fatty acids--and made their comparative assessment in the cystic and hepatic bile fractions in 25 children with chronic cholecystitis (CC). Chronic cholecystitis is characterized by dislipoproteinemia in the cystic and hepatic bile fractions, which is displayed as a reduction of the level of tauroacids and augmentation of glycocholic acid at a simultaneous increase in levels of primary and secondary biliary acids, as an increase in the ratio of levels of free fatty acids and cholesterol esters (CE) against the background of the decreasing number of monoglycerides and CE; as an increase in the ratio of levels of lysophosphatidylcholine (lysoPTC) and phosphatidylcholine against the background of augmentation of lysoPTC and phosphatidylethanolamine; as augmentation of polyene fatty acids in the composition of general lipid bile fractions. It is assumed that the obtained results can be used as indices of efficacy of drugs and non-medicinal preparations prescribed with the purpose of correction of lipid metabolic imbalances in case of chronic cholecystitis in children.