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Pulmonary abnormalities in patients intravenously receiving the methanol extraction residue (MER) of bacillus calmette‐guerin

Eight of 64 patients receiving intravenous administration of methanol extraction residue (MER) of Bacillus Calmette‐Guerin (BCG), developed miliary‐type pulmonary parenchymal changes. The clinical and radiological characteristics are described. An increased incidence was noted in patients with a history of previous BCG exposure or with positive PPD skin reactivity. Spontaneous resolution was observed upon discontinuation of MER. These changes most likely represent a granulomatous inflammatory process, although no histological confirmation was obtained.