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Influence of ultrasound on the electroretinogram and ultrastructure of the frog retina.

Electroretinography and electron microscopy were used to analyze frog retinas exposed to ultrasound. Toxic doses of ultrasound reduce the ERG b-wave amplitude and induce irreversible destructive changes in cells of all retinal layers. Therapeutic doses of ultrasound increased the b-deflection amplitude and led to slight mitochondrial edema and a decrease in the osmiophilicity of rods and cones. These studies support the view that therapeutic ultrasound doses increase the activity of photoreceptor cells.