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Interstitial Magnetic Resonance Lymphography: Comparative Animal Study of Gadofluorine 8 and Gadolinium Diethylenetriamine-Pentaacetic Acid

Purpose We evaluated the usefulness of gadofluorine 8 (G8) and gadolinium diethylenetriamine-pentaacetic acid (Gd-DTPA) for interstitial magnetic resonance lymphography (MRL). Method Phantom imaging studies were conducted with G8 and Gd-DTPA corresponding to 0.1–0.005 &mgr;mol Gd/mL, and signal intensity was measured. Popliteal lymph node (PLN) accumulation was investigated in rabbits. Imaging was performed before and after subcutaneous administration of G8 (50 &mgr;mol Gd/mL) and Gd-DTPA (50 &mgr;mol Gd/mL). Contrast enhancement ratio measurements of PLN were determined both prior to and following the administration. Results Signal intensity of phantom for G8 are higher than those for Gd-DTPA from 0.1 to 0.002 &mgr;mol Gd/mL (P < 0.0001). Imaging after 5 minutes can clearly detect PLN accumulation on two contrast agents. Nevertheless, PLN accumulation of Gd-DTPA disappeared after about 30 minutes. A statistically significant difference between G8 and Gd-DTPA can be seen from 5 to 90 minutes in CER (P < 0.0001). PLN became clearly visible at 5 minutes after the injection of G8 and Gd-DTPA. Nevertheless, PLN accumulation of Gd-DTPA disappeared at 30 minutes. Otherwise, PLN accumulation of G8 continued up to 90 minutes. Conclusion These studies indicated that G8 was more suitable than Gd-DTPA as a contrast agent for interstitial MRL up to 90 minutes.