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APOE ε4 alters docosahexaenoic acid's influence on preclinical markers of Alzheimer disease

Docosahexaenoic acid (DHA) is the main long chain omega‐3 polyunsaturated fatty acids in the brain and accounts for 30% to 40% of fatty acids in the grey matter of the human cortex. Although the influence of circulating DHA levels on memory function is widely researched, its association with brain volumes is under investigated and its association with spatial navigation is virtually unknown. This is despite the fact that spatial navigation deficits are a new cognitive fingerprint for symptomatic and asymptomatic AD, and that spatial navigation crucially relies on hippocampal and the entorhinal cortex integrity. Thus, we investigated the relationship between DHA levels and the major structural and cognitive markers of preclinical AD, namely hippocampal volume, entorhinal volume, and spatial navigation ability, across two independent non‐demented populations.