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Antisense‐mediated post‐transcriptional silencing of SCN1B gene modulates sodium channel functional expression

Voltage‐dependent sodium channels are membrane proteins essential for cell excitability. They are composed by a pore‐forming α‐subunit and one or more β subunits. Nine α subunit and five β subunit isoforms have been identified in mammals: β1, its splice variant β1B, β2, β3 and β4. Although they do not form the ion channel pore, β subunits modulate both function as well as expression of sodium channels on cell membrane.