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The Cambridge dilemma.

A marked depletion of the CD8 T cell subset in the peripheral blood of patients with arteritis temporalis and polymyalgia rheumatica (AT/PMR) has now been reported from several centres' and has been found in 80-90% of patients with active, untreated disease.6 How is it, then, that the group from Addenbrooke's Hospital in Cambridge in a report on this subject in the November 1993 issue of the Annals7 concluded "that the case that CD8+ cells are lowered in patients with PMR/AT is not proven"? We would like to comment on the paper in the light of our and other recent results. In the period 1984-91 we performed temporal artery biopsy and simultaneous determination of the CD8 T cell subset in 411 patients.8 All patients were admitted to hospital; between 08:00 and 09:00 (before the subject undertook any exercise), blood specimens were drawn and separated within 30-60 minutes with the Ficoll-Hypaque method, followed by immediate incubation