{'fraction_non_alphanumeric': 0.05859872611464968, 'fraction_numerical': 0.07006369426751592, 'mean_word_length': 4.614285714285714, 'pattern_counts': {'":': 0, '<': 1, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
[Feature analysis of IDH1 mutation in oligodendroglial tumors].

OBJECTIVE
To analyze the features of isocitrate dehydrogenase 1 (IDH 1) mutation in 165 oligodendroglial tumors.


METHODS
IDH1 was detected in a series of 165 oligodendroglial paraffin specimens from 2009 to 2011. And their features were analyzed.


RESULTS
Mutant IDH1 was detected in 111 (67.3%) tumors including 109 (98.2%) CGT→CAT mutations, 1 (0.9%) CGT→AGT mutation and 1 (0.9%) CGT→TGT mutation. The frequencies of IDH mutation in AO, O and OA were 13/15, 83.3% and 72.9% respectively. They were significantly higher than that in AOA (27.0%, P < 0.001).


CONCLUSION
The different frequencies of IDH1 mutation in different subsets of oligodendroglial tumors may imply varied tumorigenic pathways between subsets.