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Two Forensic Autopsy Cases of Liposarcoma

Primary liposarcoma outside thighs is rare. We present two forensic autopsy cases of clinically undiagnosed primary liposarcoma (Case 1: Mediastinum, Case 2: Mesentery). Case 1 was a thin male in his 60s who had a well-differentiated liposarcoma (850 g, 23 cm × 20 cm × 10 cm) in the superior mediastinum. Case 2 was a thin female in her 50s who had a pleomorphic liposarcoma (10 kg, 40 cm × 25 cm × 11 cm) in the abdominal cavity with liver metastases. The cause of death in Case 1 was airway obstruction due to liposarcoma of the neck; that in Case 2 was complications of liposarcoma with metastasis. Because liposarcoma often appears in deeper tissue without pain, it will grow quite large before it is noticed.