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Staphylococcus aureus biofilm activates the nucleotide‐binding oligomerization domain containing 2 (Nod2) pathway and proinflammatory factors on a human sinonasal explant model

The presence of Staphylococcus aureus biofilms on sinonasal mucosal surfaces is associated with recalcitrant chronic rhinosinusitis (CRS), but little is known about the innate immune response they trigger. We aimed to study the human pattern recognition receptor (PRR) nucleotide‐binding oligomerization domain containing 2 (Nod2) receptor and downstream pathway in response to initial S. aureus biofilm infection.