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Regenerative medicine in the treatment of gastro-esophageal reflux disease and laryngo-pharyngeal reflux. From research to cure.

We present our observational study on 40 patients treated with the medical device containing sodium
hyaluronic acid and magnesium alginate, performing a lubricating and hydrating action. This device
is in the form of a gel, with topical action to contrast gastroesophageal reflux and to exert a mechanical
role of protection of the mucosal tissues (mouth-pharyngo-esophageal mucosa and gastric mucose.). Forty
patients were recruited aged between 22- and 72-years-old with painful dyspeptic Gastro Esophageal
Reflux Disease (GERD) symptomatology in acute or in clinical phase (25 patients) and with pharyngolaryngo-
tracheal symptomatology (15 patients). Patients were divided into two clinical groups: Group
A was treated with the medical device, while Group B with conventional treatments without the medical
device. Subjects of both groups were also treated with proton pump inhibitors (PPIs). Follow-up was at
10, 20 and 30 days and patients were evaluated for reduction of their subjective symptoms, reduction of
symptomatic and occasional therapies, reduction of inflammatory process or disappearance of epithelial
lesions of the examined mucosa, healing process. The reduction of subjective symptoms was observed at 10
days in the patient with food bolus (disappearance after 5 days) and in patients with a reduction of 70%. A
relevant reduction in the use of symptomatic drugs was noted. Our data are relevant considering symptom
relief (heartburn, reflux and dyspepsia). New scenarios for the treatment of inflammatory diseases of the
digestive and respiratory tract mucosa are at the horizon. Interdisciplinary translational research brings
to the development of novel medical devices (as the one described in this study) with a high safety profile,
and extremely active on the inflammation-repair-regeneration complex of different tissues and organs.