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15 N Hyperpolarisation of the Antiprotozoal Drug Ornidazole by SABRE in Aqueous Medium.

Signal Amplification by Reversible Exchange (SABRE) offers a cost-effective route to boost NMR signal by several orders of magnitude by employing readily available para-hydrogen as a source of hyperpolarisation. Whilst 1 H spins have been the natural choice of SABRE hyperpolarisation since its inception due to its simplicity and accessibility, limited spin lifetimes of 1 H makes it harder to employ them in a range of time dependent NMR experiments. Heteronuclear spins e.g. 13 C and 15 N in general have much longer T1 lifetimes and thereby found to be more suitable for hyperpolarised biological applications as demonstrated previously by techniques e.g. PHIP and DNP. In this study we demonstrate a simple procedure to enhance 15 N signal of an antibiotic drug ornidazole by up to 71,000 folds with net 15 N polarisation reaching ~23%. Further, the effect of co-ligand strategy is studied in conjunction with the optimum field transfer protocols and consequently achieving 15 N hyperpolarised spin lifetime of >3 mins at low-field. Finally, we present a convenient route to harness the hyperpolarised solution in aqueous medium free from catalyst contamination leading to a strong 15 N signal detection for an extended duration of time.