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Structural features of non-cellular tissues of the human body during ochronosis

With the help of special methods of dehydration, the features of the structural organization of the solid phase of biological fluids of a patient with a rare genetic disease — ochronosis were revealed. Three biological fluids were taken as material for the study: urine, blood serum, and synovial fluid. For the transfer of biological fluids into a solid phase, the methods of cuneiform and marginal dehydration (technology “Litos-System”) were used. The structure of the solid phase of biological fluids was studied using stereomicroscopy in white and polarized light, as well as in a dark field. It was found that the structures of the solid phase of biological fluids reflect the main clinical signs of ochronosis, and also contains information about concomitant pathological processes. Specific structures of the solid phase of patients with ochronosis can be used as diagnostic markers of this disease.