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Origins of the First Cell. A New Model for the Spontaneous Formation of the First Living Cell Based on a Novel Approach

Abstract Whether proteins or nucleic acids were responsible for the emergence of life has been debated for a long time. Taking the observation that families of proteins display a remarkable invariance of their amino acid sequence around critical regions, such as active/binding sites, even though these proteins may represent considerable evolutionary diversity, as the naturally provided evidence of evolutionary selection of a working system, the idea is developed that: 1. Proteins had to have been first informational macromolecules that were necessary and sufficient to lead to the emergence of life; 2. it is impossible for a nucleic acid molecules to have formed, by chance, whose base sequence could yield a biologically active protein. A model is proposed to account for the emergence of the first sucessful cell according to this approach.