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PP.LB02.18: AORTIC ELASTICITY AND PULSE PRESSURE INDEX WERE WELL CORRELATED IN HYPERTENSIVE PATIENTS

Objective: Aortic elasticity, measured by aortic stiffness index (ASI) and aortic distensibility (AD), is a mirror of cardiovascular burden of the subjects. The arterial stiffness develops with increasing age, hypertension, diabetes mellitus, atherosclerosis, and chronic kidney disease. In the studies dealing with arterial stiffness, pulse wave velocity technique have been used extensively but echocardiography hasn’t been used effectively to measure arterial stiffness. Pulse pressure (PP = systolic blood pressure (SBP) minus diastolic blood pressure (DBP)) has been shown to be associated significantly to coronary artery disease, heart failure, and stroke, especially in elders. Pulse pressure index (PPI = pulse pressure/SBP) is proposed for assessment of cardiovascular outcomes and well assosciated with left ventricular filling pressure and diastolic dysfunction in patients with chronic kidney disease. The relation between ASI and PPI hasn’t been searched before. The aim of this study was to investigate association between PPI and aortic elasticity measured via echocardiography in hypertensive patients. Design and method: Ninety six consecutive subjects aged between 18 to 55 years old otherwise normal patients with hypertension were included. Blood pressure measurement, echocardiographic examination were carried out according to the published guidelines. Aortic stiffness index is calculated by using ASI = ln(SBP/DBP)/[(Asd-Add)/Add] formula, aortic distensibility is obtained by using AD[1/(103xmmHg)] = 2x [(Asd-Add)/Add]/PP formula where Asd and Add means aortic systolic and diastolic diameters respectively. The relation between PPI and ASI or AD were examined. Results: There were 26 men and 70 women in the study population with average age of 47 ± 7 years. Average left ventricle ejection fraction was 65 ± 3%. Mean body mass index value was 29.1 ± 4.5 kg/m2. Mean heart rate at the time of echocardiographic exaination was 74 ± 8 bpm. Average systolic and diastolic blood pressures were 131 ± 16 and 81 ± 6 mmHg respectively. Average ASI and AD values were 2.90 ± 0.55 and 4.49 ± 2.60 1/(103xmmHg) respectively. Both ASI (r = 0.605, p < 0.001) and AD (r = −691, p < 0.001) were well correlated with PPI. Age showed a weak but significant correlation with ASI (r = 0.296, p < 0.005) while not with PPI (r = 0.078, p = 0.451). Conclusions: This study showed that PPI and aortic elasticity were significantly correlated in hypertensive patients.