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Acute regulation of plasma leptin by isoprenaline in lean and obese fasted subjects

Aim:  In human obesity, there is some evidence for impaired adrenergic sensitivity with respect to catecholamine‐induced lipolysis. The β‐adrenoceptor agonist isoprenaline has been shown to suppress plasma leptin levels in lean humans in vivo. We hypothesized that a reduced adrenergic sensitivity in obese humans would result in impaired suppression of leptin secretion.