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Normal preoperative levels of parathyroid hormone signify a mild form of primary hyperparathyroidism

Primary hyperparathyroidism (pHPT) is characterized by an inappropriate serum level of parathyroid hormone (PTH) in relation to the serum level of calcium. Nowadays, patients often are diagnosed with an overtly asymptomatic pHPT with mild or even intermittent hypercalcaemia. Indeed, health screening surveys have shown that a significant proportion of patients with pHPT is normocalcaemic. Most studies also demonstrate patients with PTH levels in the upper normal range. The aim of the present study was to define subgroups of patients with mild pHPT, which potentially could give valuable insights into the pathogenesis of the disease.