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ANTI‐APOPTOTIC EFFECT OF ATORVASTATIN, A 3‐HYDROXY‐3‐METHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR, ON CARDIAC MYOCYTES THROUGH PROTEIN KINASE C ACTIVATION

1. Pleiotropic effects of statins, which are independent of lipid lowering, have been reported. In the present study, we examined the effect of a statin on apoptosis of adult rat cultured cardiac myocytes. We used the protein kinase C (PKC) inhibitors staurosporine (1 µmol/L), chelerythrine (10 µmol/L) and rottlerin (5 µmol/L) to induce myocyte apoptosis. The effect of atorvastatin (10−7 g/mL), a statin, on myocyte apoptosis induced by these PKC inhibitors was examined.