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Theoretical approach to the hit probability of lung‐cancer‐sensitive epithelial cells by mineral fibers with various aspect ratios

Background:  Inhalation of fibers may lead to the damage and, as a further consequence, to the malignant transformation of specific (most of all non‐ciliated) cells of the bronchial and bronchiolar airway epithelium. In order to accurately estimate the cancer risk induced by inhaled fibers, hit probabilities of non‐ciliated (secretory) cells by mineral fibers (asbestos and chrysotile) were computed.