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[Effect of Rehmannia glutinosa Libosch water extraction on gene expression of proinsulin in type 2 diabetes mellitus rats].

OBJECTIVE
To investigate the mechanisms of treating 2-DM by Rehmannia glutinosa Libosch water extraction (RGLE).


METHODS
The mRNA level of proinsulin in rats panreas tissue was examined by semi-quatitativa RT-PCR,and the protein was measured by SDS-PAGE.


RESULTS
The mRNA and protein expressions of proinsulin in RGLE group were higher than those of diabetic model group (P<0.01). The levels of FPG decreased. FINS,IS, HbetaCI increased (P<0.01).


CONCLUSION
It may be the mechanism how the RGLE to decline high FPG and cure the 2-DM.