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Vasopressin and Oxytocin in Regulation of Renal Cation and Water Excretion: Nephrone ‐ Kidney Interaction

Hydrin, mesotocin, vasotocin are the neurohypophyseal nonapeptides of the vertebrates except the mammals, arginine‐vasopressin (AVP) and oxytocin (OT) are secreted into blood in man and rat. The activation of V‐ and OT‐receptors (OTR) provides different functions of the peptides, including osmoregulation. AVP effect on sodium transport in tubule cells was shown earlier: increased Na+ reabsorbtion was observed in TAL due to activation of V2R, and decreased Na+ reabsorbtion ‐ due to activation of V1aR. The aim of the study was an investigaion of the effect of the nonapeptides in vivo and evaluation of cumulative reaction of all the nephrone populations on renal ion and water excretion.