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Estimate Of Pulsatile Cerebral Blood Volume Change Derived From The Intracranial Pressure Signal

Digitized recordings of electrocardiographic and intracranial pressure signals were obtained from standard bed-side physiologic monitors in the neurosurgical intensive care setting. Assuming an exponential relationship between intracranial pres.sure and intracranial volume and using standard numericaltechniques, estimates of pulsatile change in cerebral blood-volume over each cardiac cycle were derived. Pulsatile change in cerebral blood-volume varied during the respiratory cycle, reaching a maximum during expiration and a minimum during inhalation. The magnitude of average difference in pulsatile cerebral bloodvolume between expiration and inhalation may be an indicator of the magnitude of the non-vascular component of intracranial elastance.