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Enhancement of peptide immunogenicity by linear polymerization

The effect of linear homopolymerization on the immunogenicity of synthetic peptides was studied using either haptenic peptides (representing amino acid sequences 103‐115 and 133‐147 of bovine rotavirus major protein) or immunogenic peptides TD‐103‐115 and TD‐133‐147 which were constructed by co‐linear synthesis of the former peptides and an amino acid sequence representing a determinant recognized by T helper cells (TD). It was found that the two haptenic peptides were rendered immunogenic by linear homopolymerization. Moreover, homopolymerization also enhanced the immunogenicity of TD‐103‐115 but not that of TD‐133‐147. In the three cases where polymerization enhanced immunogenicity, a reinforced amphipathic pattern was predicted in the neighborhood of the junction of the monomers. The possibility that polymerization might have generated a new T cell determinant is discussed.