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Cytoplasmic accumulation of α‐catenin in thyroid neoplasms

Alpha‐catenin (α‐cat) is one of the anchoring proteins of E‐cadherin. It has been shown that deviation in its function may alter the cadherin–catenin complex leading to disturbed cell–cell adhesion. Immunohistochemical studies have shown that cytoplasmic localization of α‐cat in tumors is associated with aggressive behavior. In this study, we evaluated the expression of α‐cat in various thyroid tumors by immunohistochemical analysis.