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Scleroderma: A Review of Vascular Features

Scleroderma (systemic sclerosis, SSc) is a connective tissue disease characterized by fibrosis of organ systems associated with vascular abnormalities and with distinctive serological autoimmune features. While organ fibrosis is the most clinically obvious feature of the disease, particularly in the skin, the underlying vascular changes are thought to play a crucial role in its pathogenesis; these capillary, arteriolar and small artery lesions have been shown to accompany and often precede fibrosis in SSc target organs.