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[The HIF1a polymorphism is a diagnostic marker of ischemic stroke].

AIM
To study a variant of the C1772T polymorphism of the hypoxia inducible factor-1a (HIF1a) gene as a molecular genetic predictor of increased risk of ischemic stroke.


MATERIAL AND METHODS
The study included patients with ischemic stroke which was confirmed clinically and by MRI (n=1200), the control group consisted of 500 patients without cardiovascular disease. DNA was extracted from the venous blood using the phenol-chloroform method. Determination of alleles was performed using allele-specific RealTime PCR as well as PCR/RFLP diagnosis.


RESULTS
The carriage of one or two copies of the allele T significantly increases the risk of ischemic stroke (OR=1.603, p=0.01). At the same time, the minor allele was not associated with the prognosis of the disease outcome.


CONCLUSION
The results allow us to consider the HIF1 C1772T polymorphism as a new molecular genetic predictor of ischemic stroke.