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GlycoSense™: A Simple Alternative to Existing Methods for Glycosylation Detection and Monitoring

Lectenz® Bio has developed an innovative technology called GlycoSense™ that detects binding between glycans and glycan‐specific reagents that are conjugated to spectrally‐unique beads. By combining the individual bead‐based reagents into a multiplex array, a profile of key glycan features can be obtained in less than a minute on a basic cytometer. We illustrate the performance of the method using glycoprotein standards and demonstrate its utility by monitoring changes in glycosylation patterns upon treatment with glycoenzymes. The GlycoSense™ approach addresses the unmet need for a rapid and robust tool to analyze protein glycosylation. In addition to established carbohydrate‐detection reagents such as antibodies and lectins, this approach can employ the engineered proteins (known as Lectenz®), developed by Lectenz® Bio.