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HLA patterns and diabetic retinopathy.

The major cauise of morbidity in insulin-dependent diabetic patients is vascular complications-particularly microangiopathy, as reflected by retinopathy and nephropathy. The factors influencing the development of these complications remain poorly understood. Studies in diabetic identical twins have suggested that genetic factors may have a role not only in the liability to diabetes but also in the likelihood of diabetics developing retinopathy.1 The pattern of HLA antigens is genetically determined and an association between the HLA pattern and several diseases, including insulin-dependent diabetes, has been well established. This investigation aimed at seeking an association between the HLA pattern and liability to or protection from severe diabetic retinopathy in insulin-dependent diabetic patients. Because of a recent report in abstract form,2 we directed our attention to the antigens HLA-A1 and HLA-B8.