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Placental Exposure to Hypoxia and Oxidative Stress Causes Mitochondrial DNA Release into the Extracellular Space

In preeclampsia, a severe hypertensive disorder of pregnancy, placentae experience reduced perfusion, increased cell death, and oxidative stress, with an increase in circulating cell‐free mitochondrial DNA (mtDNA). Our lab has shown that a synthetic mimetic of mtDNA during rodent pregnancy increases maternal blood pressure and vascular reactivity, features of human preeclampsia. The main objective of this study was to determine the role of hypoxia and oxidative stress in mtDNA release from placental cells, and to examine the effects of soluble factors from hypoxia‐exposed placentae on vascular reactivity.