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Catecholamines, adrenal hormones, and stress.

From its beginnings about a century ago, research into the mechanisms underlying the stress response has led by many avenues to the adrenal medulla and its chromaffin cells. The latter possess cholinergic synapses that, when activated by a wide variety of stimuli, trigger discharge of catecholamines directly into the blood. Control of the response is mediated by a final common pathway arising in the hypothalamus and/or midbrain.