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Mouse alloantibodies capable of blocking cytotoxic T cell function. II. Further study on the relationship between the blocking antibodies and the products of the Lyt‐2 locus

The specificity of mouse alloantibodies which blocked allogeneic killer cells has been confirmed as Ly‐2.2 using B 6 × C 3 H recombinant inbred (RI) strains. All of the RI strains tested were sensitive to the cell‐mediated lymphocytotoxicity (CML)‐blocking effect of our C3 H anti‐B 10.BR antisera and also carried the Lyt‐2b allele. This result and studies using Lyt‐2‐congenic strains firmly localized the genes encoding the target antigen of CML‐blocking antibodies in or near the Lyt‐2 locus. In addition, a monoclonal anti‐Lyt‐2.2 antibody was found to block the CML reaction of B 6 killer cells, but not that of B 6 Ly‐2.1 killers. Blocking antibodies to one allele blocked killing by Lyt‐2‐heterozygous F1 killer cells, but the inhibition curve reached a plateau at a significantly lower level than that seen on the killer cells of the sensitive parent. Our results thus suggest that Lyt‐2 antigens are of functional significance on killer T cells, but do not reveal whether or not that significance involves the T cell receptor.