{'fraction_non_alphanumeric': 0.01797175866495507, 'fraction_numerical': 0.0019255455712451862, 'mean_word_length': 5.261044176706827, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
BEYOND PAIN : FUNCTIONAL ALTERATIONS IN THE REWARD-AVERSION BRAIN SYSTEM INDUCED BY CHRONIC PAIN

Final results: We obtained results on five distinct topics: a) using multielectrodes implanted in the orbitofrontal cortex of adult rats performing the Rodent Gambling Task, we have shown that the neuronal firing rate was correlated with the probability of choosing a low versus high-risk food reward in each trial. b) using multielectrodes implanted in the hippocampus of rats performing a foodreinforced alternation task, we showed that neuropathic pain induces an increase of the number of place fields encoded in the hippocampal networks. c) using continuous 24-hour recordings in the thalamocortical loop, we showed that chronic pain disrupts sleep patterns, and causes a large decrease in the functional connectivity in the thalamocortical axis. d) using in vivo recordings, patch clamp in brain slices, and various behavioral assays, we showed that pain increased neuronal activity in the amygdala that triggered a decrease in prefrontal activation and impaired decision-making. e) using multielectrodes implanted in the hippocampus and in the prefrontal cortex we showed that pain induces a clear impairment of working memory performance that is temporally correlated with a decrease in single neuron activity in the mPFC. f) we demonstrated that the lack of pain in the KO mice Prrxl1 -/of congenital hypoalgesia causes a behavioural and neurophysiological pattern of brain activity that is the inverse of what we observe in animals with chronic pain.