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8q24 translocations in blastic transformation of mantle cell lymphoma.

We report four cases of blastic transformation of mantle cell lymphoma (MCL), cytogenetically characterized by 8q24 karyotypic abnormalities in addition to t(11;14), suggestive of c-myc deregulation. Three patients developed blastic disease in lymph nodes, peripheral blood and bone marrow, after one to seven years, and died after 1 to 3 months. One patient presented with blastic MCL and died after 15 months. We propose that c-myc activation may be another cell cycle deregulation event leading to aggressive transformation in MCL.