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Reader response: Association between diabetes and subsequent Parkinson disease: A record-linkage cohort study

The article by De Pablo-Fernandez et al.1 reported that type 2 diabetes mellitus (DM) was associated with increased hazard of Parkinson disease (PD) (hazard ratio 1.32, 95% confidence interval 1.29–1.35). The authors proposed that DM and PD might share a similar genetic predisposition with potential opportunities to develop therapeutic strategies.1 To the contrary, other studies revealed a negative association or no association between DM and PD.2,3 One meta-analysis revealed data from cohort studies that suggested DM being associated with an increased risk of PD, but case–control studies did not reveal such an association.4 There seems to be no conclusive evidence on this association.