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Non-Effectiveness of Azadirachta indica (Neem Tree) Leaf Extract against the Larvae of Angiostrongylus cantonensis and Trichinella spiralis.

The effectiveness of the leaf extracts of Azadirachta indica (neem tree) against two nematodes, Angiostrongylus cantonensis and Trichinella spiralis was investigated in mice. Laboratory mice were inoculated with the nematodes followed by the oral administration of the leaf extracts. Two standard drugs, flubendazole and mebendazole were compared with the plant extract in the study. No significant effects of the leaf extract against the nema- todes were observed. Thus, although the extract has been shown by other investigators to be animalarial, antibacterial and antifungal, no activity was observed against the two nematodes in this study.