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Estimation of the applicability of differential spectroscopic method for the determination of lisinopril in tablets and for the evaluation of its stability.

Classic spectroscopy and first-, second-, third derivative UV-spectroscopy methods were applied to the determination of lisinopril (LIS) in the model solutions, tablets as well as to estimate its stability in solid phase. These results were compared with results received by the HPLC method. Derivative UV-spectroscopy and the HPLC method was tested for: selectivity, precision, linearity, accuracy and repeatability. The study shows that derivative UV-spectroscopy (only first and second derivative) and HPLC can be successfully applied for the quantitative analysis of lisinopril in pharmaceutical formulations and evaluation of its stability in solid phase.