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[Synthesis of N1-(aryl)alkyloxyacyl-5-fluorouracil derivatives].

OBJECTIVE
To synthesize N1-(aryl)alkyloxyacyl-5-fluorouracil derivatives and investigate their antitumor activities.


METHODS
Title compounds (I) were prepared by 5-fluorouracil which was trimethylsilylated by hexamethyl-di-silazane, and then acylated. Hydrogenization of compounds (I) brought on compounds (II), which were esterified to produce title compounds (III) afterwards.


RESULTS
Twelve title compounds were synthesized.


CONCLUSION
These compounds were designed products confirmed by 1H-NMR, IR and MS spectral data.