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Chlorpromazine and Horner ’ s Syndrome

Horner’s syndrome is characterized by an interruption of the sympathetic nerve pathway somewhere between its origin in the hypothalamus and the eye. We describe a case of Horner’s syndrome in a 13-year-old girl during chlorpromazine therapy. Phenothiazines are strong α-adrenergic antagonists with consequent inhibitory action on sympathetic innervation. The low daily dose, 40 mg, suggests a complex etiology (German J Psychiatry 2005; 9: 33-35).