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Uterine rupture with the use of vaginal prostaglandin E2 suppositories.

We have no objection if Dr. Bourke prefers to use the statement “the study did not detect any effect on FHR or FHRV‘ rather than that which we published. However, we reexamined our data using paired t-test and Mann-Whitney U test and we still found no changes in FHR. At this point we feel that with the number of cases we have done, our conclusion is reasonable. We question whether it is warranted to triple the number of patients to possibly detect a 10 beatimin change in baseline FHR, which clinically is considered to be not significant and perhaps statistically not significant either.