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Effects of serum biochemical parameters on the prevalence of colon polyps

DOI: 10.4328/ACAM.20521 Received: 2021-02-05 Accepted: 2021-03-20 Published Online: 2021-04-02 Printed: 2021-07-01 Ann Clin Anal Med 2021;12(7):775-779 Corresponding Author: Muhammet Fatih Aydin, Altinbas University, Bahcelievler Medical Park Hospital, Department of Gastroenterology, Mahmutbey Dilmenler street, No:26, 34217, Istanbul, Turkey. E-mail: mdfatihaydin@gmail.com P: +90 212 604 01 00 F: +90 212 445 81 71 Corresponding Author ORCID ID: https://orcid.org/0000-0001-6056-9360 Abstract Aim: Early detection of colorectal polyps is important to prevent malignant transformation. The levels of several metallic and hematologic parameters may be indicators of these polyps. The objective of this study was to investigate whether iron levels may indicate the presence of colorectal polyps. Material and Methods: A total of 897 patients who underwent routine biochemical analysis and colonoscopy were retrospectively evaluated. Patients were grouped as polyp (-) and polyp (+) and further divided into two groups as those with neoplastic polyps and the patients with non-neoplastic polyps. The levels of iron, ferritin, hemoglobin, glucose, cholesterol, triglycerides and vitamin D were compared between the groups. Results: Males accounted for 60.5% of all patients, and 39.5% were females. The mean age of the patients was found as 43.3±11.9 years. The mean iron (p=0.023), ferritin (p=0.002), cholesterol (p=0.008) and triglycerides (p=0.005) levels were significantly higher in patients with polyps compared to those without polyps. The mean iron (p=0.001), ferritin (p<0.001), hemoglobin (p<0.001) and triglyceride (p=0.007) levels were higher in the males compared to the females. The mean iron (p<0.001), ferritin (p<0.001) and cholesterol (p=0.020) levels were significantly higher in patients with neoplastic polyps compared to those with non-neoplastic polyps. Discussion: Iron levels were elevated in individuals with colorectal polyps and further elevated in patients with neoplastic polyps. Determination of cut-off values of iron and other parameters in predicting colorectal polyps will enable early detection of colorectal polyps and proper intervention.