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337 A COMPARISON OF THE PHARMACOKINETICS OF NETILMICIN AND GENTAMICIN IN NEWBORNS

In a prospective double-blind randomized study, 20 newborn infants were given either NT or GT IV 5mg/kg/day, q 12h for presumed septicemia. After at least 4 doses of aminoglycoside antibiotic, serum samples were drawn prior to and 0.5, 2, 4, 8, and 12 hours after infusion. (Antibiotic concentrations in sera were determined by microbioassay).The following were determined for each drug: t½=half life, kel=rate of elimination, Vp=apparent volume of central compartment Cpo=theoretical concentration of aminoglycoside in plasma at t=0.There were no statistically significant differences in serum values at any time (see graph) or in pharmacokinetic parameters (see table.)Our data indicate that the pharmacokinetics of netilmicin and gentamicin in the newborn are comparable.