{'fraction_non_alphanumeric': 0.05056890012642225, 'fraction_numerical': 0.020859671302149177, 'mean_word_length': 5.111969111969112, 'pattern_counts': {'":': 0, '<': 1, '<?xml version=': 0, '>': 1, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Significance of a solid component in the papillary thyroid carcinoma associated with clinicopathological parameters

Aims Solid variant of papillary thyroid carcinoma (SVPTC) is characterized by a solid component (SC) involving more than 50% of the tumor with the preservation of the classical cytological features of papillary thyroid carcinoma (PTC). However, clinical significance of SC in PTC has rarely been examined. Herein, we retrospectively investigated the clinicopathological features of PTC with various degree (10 to 85%) of SC (PTCSC). Methods Patients with PTCSC (n=27) were stratified into SC-major (SC >50% of the tumor) and SC-minor (SC <49%) groups. The clinicopathological parameters were compared to well-differentiated PTC (WPTC) group (n=47). Results Both SC-minor (n=18) and SC-major (n=9) groups had increased incidence of a large-sized tumor, extra-capsular extension, and a high recurrence rate, compared to WPTC. Disease-free survival (DFS) of both SC-minor and SC-major was shorter than that of WPTC (p=0.035 and 0.016, respectively). Overall survival was similar among all the groups. Univariate analysis revealed that SC was significantly associated with a A cc ep te d A rt ic le This article is protected by copyright. All rights reserved. recurrence rate (p=0.018). By multivariate analysis, SC appeared to be associated with a recurrence rate with the borderline significance (p=0.055) Conclusions Our findings indicate that the presence of SC in PTC, regardless of the proportion, is associated with adverse clinical parameters and a shorter DFS.