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Diffusion-weighted MRI in severe leukoaraiosis.

To the Editor: 

Recent articles1 2 have reported that diffusion-weighted MRI (DWI) is useful in both detecting very early ischemic lesions and identifying the responsible lesion in multiple subcortical lesions. Singer and colleagues1 described the very high accuracy of DWI for their 39 subjects with acute subcortical infarction. They reported that the sensitivity of DWI for acute subcortical infarction was 94.9% and the specificity was 94.1%. But they did not refer to its relation to the periventricular hyperintensity area (PVH).

We studied 18 cases (10 men and 8 women; mean age, 72±7.9 years) with serial acute cerebral infarction. They were consisted of 3 cases with cortical infarction and 15 cases with subcortical infarctions, including infratentorial regions. …