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Disseminated Intravascular Coagulation with Microangiopathic Haemolytic Anæmia in Eclampsia

Comment Microangiopathic haemolytic anemia is a term used by Brain et al. (1962) to indicate the possible role of altered blood vessels in the pathogenesis of himolysis. Furthermore, Brain et al. (1967) have shown that the red cell participates in the development of the vascular thrombi in the generalized Schwartzmann reaction, produced by endotoxin or thrombin infusion. In malignant hypertension and in some cases of eclampsia there may be abnormalities of the blood vessels. A stimulus may be derived from the placenta which activates procoagulant factors to permit the formation of thrombin and induce disseminated intravascular coagulation and fibrin deposition, resulting in fragmentation ofred cells and heemolysis. Heparin has been shown to be of benefit as in one of the cases reported.