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Inhibition of Apoptosis by Angiotensin 1‐7/mas Pathway through MKP‐2 Activation in Alveolar Epithelial Cells

The autocrine generation of angiotensin II (ANGII) and c‐Jun‐N‐ terminal kinase phosphorylation (pJNK) are both required in alveolar epithelial cell (AEC) apoptosis which contributes to lung diseases. Angiotensin 1‐7 (ANG 1‐7) protects against AEC apoptosis which is induced by ANG II. However the exact inhibitory mechanisms of ANG 1‐7 and the mas receptor are currently unclear in AECs. The objective of the current research is to identify the role of map kinase phosphatase (MKP‐2) in AEC survival. We hypothesized that ANG 1‐7 activates MKP‐2 and maintains low pJNK levels thereby preventing apoptosis.