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Inferences and conjectures in clinical trials: a systematic review of generalizability of study findings

Despite the considerable literature available on this topic, the issue of generalizability of findings from randomized trials (RTs) remains poorly understood. This letter aims to (i) report the results of an extensive review of the recent literature with respect to how generalizability of RT is presently evaluated and reported, and (ii) provide recommendation on studydesign, data collection, analytic approachand interpretation of findings of RT’s.