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Letters to the Editor Morphological Quantitation of Emphysema: A Debate The following series of letters to the editor concerns a recently published morphologic method proposed by Parameswaran and colleagues for sensitive, early detection of emphysema

The following series of letters to the editor concerns a recently published morphologic method proposed by Parameswaran and colleagues for sensitive, early detection of emphysema (J Appl Physiol 100: 186–193, 2006). The validity of the proposed method was critiqued by Ewald Weibel, and, in turn, this critique was rebutted by Parameswaran et al. Additional brief commentaries were contributed by scientists working in the field. Further comments on this important topic are welcome.