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Presentation Title: Systematic in Vivo Electroencephalographic Characterization of Spatial Phase Coupling in Mouse Models of Schizophrenia Location: Hall F-j

Print View Abstract: It is well known that certain phenotypes of neural circuit dynamics, such as anomalous levels of power and/or spatial phase coupling in the gamma and theta frequency ranges, are characteristic of mental disorders like schizophrenia. In order to uncover the underlying neurobiological mechanisms of these spatio-temporal network abnormalities, it is important to model the disorder in model species such as mice. However, work of this kind is currently faced with two long-standing challenges. First, due to the 3 to 4 orders of magnitude difference in brain volume between mouse and human, conventional techniques capable of probing spatial interactions among distinct brain areas in human subjects, such as electroencephalography (EEG), cannot be directly translated to the mouse without properly standardized miniaturization, leaving a blank in the work of EEG characterization of schizophrenia-related phase coupling across distinct cortical loci in freely behaving mice. Secondly, the existence of numerous and hugely diverse mouse models of schizophrenia, as a result of the complexity in etiology of the disease, calls for a reliable means to compare and contrast specific neural circuit mechanisms consequent of a wide range of genetic, pharmacological and environmental perturbations that result in schizophrenia-like behavioral phenotypes. Although neurochemical commonalities, such as NMDA receptor hypofunction and deficient inhibitory neurons, have been reported in