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Etiological structure of infectious complications and microbial colonization in patients of COVID-19 hospital of a multidisciplinary federal medical institution // Epidemiology and infectious diseases.

The aim of the study is to describe the etiological structure of infectious complications and microbial colonization in patients of the COVID-19 Hospital on the basis of a multidisciplinary federal medical institution. Materials and methods: Clinical samples (blood, lower respiratory tract discharge, urine, other biological materials) of patients with COVID-19 who were treated in the COVID-19 Hospital on the basis of a multidisciplinary federal medical institution were obtained and processed. Results: The bacteriological laboratory received 1821 samples of biomaterial from 452 patients, microorganisms were isolated from 620 (38.0%) samples. Most of the biomaterial is represented by blood - 35.9% and 31.7% of the lower respiratory tract separable. The structure of microorganisms was dominated by C. albicans - 19.7%, S. aureus - 10.2%, K. pneumoniae - 10.1%, E. faecalis - 7.9%. In the initial period of operation of the Hospital, the most frequently sown microorganisms were S. aureus and H. influenzae - 19.7% and 7.9%, respectively, in the final period there was a change in the spectrum of microorganisms to nosocomial ESKAPE pathogens with multidrug resistance (MDR), the structure was dominated by A. baumannii - 24.3%. The consumption of antibiotics in the hospital increased from 18.3 DDD/100 patient days in 2019 to 28.8 DDD/100 patient days in 2020. Conclusion: Significant colonization of various loci of patients with COVID-19 fungi of the genus Candida was revealed. There was a change in the microbial spectrum of infectious agents from community-acquired (H. influenzae and S. pneumoniae) to nosocomial ESKAPE pathogens with MDR. The consumption of antibiotics has significantly increased.