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Dorsoventral differences in Kv7/M‐current and its impact on resonance, temporal summation and excitability in rat hippocampal pyramidal cells

Kv7 (KCNQ/M) channels are known to control excitability and generate subthreshold M‐resonance in CA1 hippocampal pyramidal cells, but their properties and functions have not previously been compared along the dorsoventral (septotemporal) axis We used whole‐cell recordings to compare electrophysiological properties of dorsal and ventral CA1 pyramidal cells in hippocampal slices from 3‐ to 4‐week‐old rats Blockade of Kv7/M‐channels with 10,10‐bis(4‐pyridinylmethyl)‐9(10H)‐anthracenone dihydrochloride (XE991) had a stronger impact on electrical properties in dorsal than ventral pyramidal cells, including input resistance, temporal summation, M‐resonance, spike threshold, medium after‐hyperpolarization, excitability, and spike frequency adaptation. Voltage‐clamp recordings revealed a larger amplitude and left‐shifted voltage dependence of XE991‐sensitive current (IM) in dorsal vs. ventral cells. IM‐dependent differences in excitability and resonance may be important for rate and phase coding of CA1 place cells along the dorsoventral axis and may enhance epileptiform activity in ventral pyramidal cells.