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Radiation therapy alone for sarcoma of soft tissue

Fifty‐one patients have been treated with radiation therapy alone for soft tissue sarcomas, with 72.5% eligible for more than 5‐year follow‐up. Thirty‐six of 51 patients received a radiation dose of 6400 cGy (or its equivalent) or greater. Careful attention was paid to the radiation therapy technique, using multiple angled fields, tissue‐compensating wedges, immobilization devices, etc., in order to preserve a good functional result. Eleven of 51 patients are alive with no evidence of disease. The overall 5‐year survival and local control rates were 25.1% and 33% respectively. For patients treated to a dose of 6400 cGy or greater, the 5‐year survival and local control were 28.4% and 43.5%, respectively. Local control was better for tumors less than 5 cm diameter (87.5%) than in tumors 5 to 10 cm diameter (53%) or greater than 10 cm (30%). Only four patients in this series had a grade I tumor, and no survival difference could be detected between Grade 2 and Grade 3 tumors. This series indicates that radiation therapy alone can control tumor in a portion of patients with soft tissue sarcomas.