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Selected laboratory parameters and seric PRR correlation as prognostic factors in patients with preeclampsia (701.6)

Preeclampsia (PE) shows high maternal‐fetal morbidity. Its pathophysiology is multifactorial. Prorrenin/renin receptor (PRR), a new component of the renin‐angiotensin system, has been implicated in hypertensive disorders. Our goal was to determine if seric PRR correlates with selected laboratory parameters as prognostic factors in PE. After ethics committee approval, we selected term pregnant patients with PE from the intensive care unit (n=8), and normal pregnant patients (n= 15). Pregnancy was interrupted within 24 hrs by cesarean incision. Blood samples were collected and analyzed for cholesterol, triglycerides, albumin, calcium, uric acid (UA), Mg, lactate and C‐reactive protein before and after pregnancy termination. Body mass index (BMI) was calculated at the beginning and end of pregnancy. Our results showed that PE patients had elevated serum cholesterol, triglycerides, C‐reactive protein and hypoalbuminemia before and after delivery. BMI, UA and Mg were significantly higher and all PE patients showed significant thrombocytopenia even 24 h after cesarean. Placental weight was significantly lower. Seric PRR was higher in PE patients and positively correlated with albumin, calcium and Mg. These results suggest a close correlation of PRR with several markers and might be used as prognosis factors during PE