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Serum neopterin levels in patients with autism

Abstract Objective: Autism is a chronic neurodevelopmental disorder with an aetiology that is not fully understood. Published findings have identified widespread changes in the immune systems of children with autism. The latest findings show that the pathophysiology of autism may be associated with cellular immunity. Neopterin is a good indicator of cellular immunity, and changes in neopterin may have diagnostic importance. Methods: The study group consisted of 23 patients with autism. An age- and gender-matched control group was composed of 21 healthy subjects. Venous blood samples were collected, and the levels of neopterin were measured. Results: The levels of neopterin were significantly higher in the autistic children than in the comparison subjects. Conclusions: Cellular immunity may have a role in the aetiopathogenesis of autism. Increased serum neopterin levels may have diagnostic importance in autism.