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Swyer-James Syndrome: Diagnostic Application of Combined Radionuclide Ventilation and Perfusion Scanning

A case of Swyer-James syndrome, mainly suggested by the conventional chest x-ray, was further studied with radionuclide ventilation and perfusion imaging. The 99 mTc-macroaggregated albumin perfusion scan revealed diffusely diminished perfusion in the left lung, which showed hyperlucency on the chest x-ray. The 133Xe ventilation scan showed markedly diminished ventilation with diffuse gas-trapping in the same lung. The scan findings correlated well with the basic pathophysiologic changes of the entity. Combined radionuclide ventilation and perfusion scanning may be a useful means of demonstrating the physiologic abnormality of this syndrom.