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Influence of adrenocorticotrophic hormone on the behaviour in the swim test of rats treated chronically with desipramine

Abstract— Chronic desipramine (DMI) administration induced a dose‐dependent reduction in the immobility time of the swim test in rats. A combined treatment of ACTH (50 iu kg−1 s.c.) and DMI (5 or 10 mg kg−1 i.p.) for 7 days potentiated the anti‐immobility effect of DMI. ACTH 4–10, a fragment peptide with little corticotrophic activity, mimicked ACTH‐induced potentiation. No stimulating effect on locomotor activity was observed following seven daily co‐administrations of ACTH or ACTH 4–10 and DMI (10 mg kg−1). This behavioural evidence indicates that ACTH potentiation involves a central mechanism and demonstrates a functional interaction between ACTH and DMI at the behavioural level.