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HLA haplotypes and hayfever: a possible protective role

The HLA haplotype frequencies of European asthmatic children and their immediate families were studied, and a disassociation between haplotype A1‐B8 and skin sensitivity to grass pollens was found, suggesting that within this allergic population, possession of the haplotype A1‐B8 conferred possible protection against grass pollinosis. There was no association between A1‐B8 and clinical asthma or between it and skin sensitivity to the house dust mite.