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Preparation and Characterization of Chelerythrine Nanoparticles Composed of Magnetic Multiwalled Carbon Nanotubes

In this study, chelerythrine nanoparticles composed of magnetic multiwalled carbon nanotubes (Fe3O4/MWNTs-CHE) were prepared by adsorption method with CHE as the model drug and Fe3O4/MWNTs nanocomposites as the drug carrier. Optimized nanoparticles were characterized by scanning electron microscopy (SEM), Zeta potential and in vitro drug release.The in vitro drug release profiles of Fe3O4/MWNTs-CHE nanoformulation exhibited a biphasic pattern with an initial fast release phase followed by a slower release phase. The CHE release profile from Fe3O4/MWNTs-CHE nanoparticles followed Korsmeyer-Peppas model with Fickian diffusion mechanism for drug release.