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Association Between Cardiovascular Health Metrics and Cancer Mortality in Men and Women: 1867 Board #19 June 2, 3: 30 PM - 5: 00 PM.

RESULTS: Patients with FACT-positive assays were significantly more likely to show improvement in their VAS and ODI at follow-up. Mean VAS improvement in FACTpositive patients was 4.9 ±0.9 and 4.0 ±1.0 at 3 and 6-months, compared to 1.5 ± 1.2 and 2.3 ±1.3 in those with negative FACT (p < 0.0001). ODI improved on average 37 ±9.3 and 28 ±14 points at 3 and 6-months in FACT-positive patients compared to 9.4 ±11.9 and 12.6 ±11.8 points at 3 and 6-months in FACT-negative patients (p<0.0001). Correlation analysis demonstrated that a FACT-positive test correlates with improvement in 3-month VAS (Pearson r = 0.83; p < 0.0001) and ODI (Pearson r = 0.71; p<0.0001) and 6-month VAS (Pearson r = 0.58; p<0.0001) and ODI (Pearson r = 0.53; p<0.0001). When a 20-point ODI improvement cut-off is applied, 77% of FACT+ patients and 27% of FACT-negative patients meet this strict definition of clinical improvement. DISCUSSION: Patients who are FAC+ within the disc are more likely to demonstrate clinical improvement following intradiscal autologous A2M injection. The results of this investigation suggest that autologous A2M may be an efficacious biologic treatment in discogenic pain and that FAC may be an important biomarker in patient selection for this treatment. We utilized a definition of clinical improvement that was in excess of the minimal clinically improved difference (MCID). This study demonstrates that a PPP concentrate rich is A2M is likely to result in clinical improvement of LBP in patients who demonstrate the FAC in the suspected disc.