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Synthesis of novel 1,5-benzothiazepine[7,6-b]-1, 8-naphthyridines under microwave irradiation via Mannich condensation

A series of novel 1,5-benzothiazepine[7,6-b]-1,8-naphthyridines 3a–j were synthesized by reaction of substituted 2-amino-thiophenol with different substituted 2-chloro-3-formyl-1,8-naphthyridines 1a–d under microwave irradiation and solvent-free condition is described. A judicious choice of the reaction conditions under microwave allowed the final products 3a–j in excellent one-step procedure, whereas experiments under thermal conditions led to 3a–j in lower yields with tedious work-up. The new compounds have been characterized with the assistance of elemental analyses, IR, 1H NMR and mass spectral studies.