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P4‐4: Role of the thiol‐disulphide system in the protection of alveolar macrophages against exposure to suspended particle matter of the atmospheric surface layer

were included in this study. The subjects were asked to answer two types of self-administered questionnaires: Daily Life Questionnaire and International Physical Activity Questionnaire (IPAQ). IPAQ was administered twice; prior to the COVID-19 pandemic and after the COVID-19 quarantine. Physical activity before the COVID-19 pandemic and after the state of emergency lifted were defined as "IPAQ baseline" and "IPAQ after COVID-19 quarantine", respectively. Results: The total number of subjects were 237, of which 161 subjects were with respiratory diseases. There was no significant difference between the IPAQ baseline and IPAQ after COVID-19 quarantine. The group with “negative” attitude toward going out showed a greater decline than the “positive” group (p<0.01). Odds ratios for decreased physical activity were “Employment” (OR, 1.95; 95%CI, 1.00-3.78, p<0.05) and “Caution against going out” (OR, 16.88; 95%CI, 0.19-59.59, p<0.01) in the analysis of all subjects. It was “Caution against going out (by self)” (OR, 14.68; 95%CI, 0.18-57.78, p<0.01) in respiratory diseases patients. Conclusion: It is showed that subjects who have negative attitudes toward going out are at high risk of decreased physical activity. In additional, it is probable that people who are not working are also at risk of physical inactivity.