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Muscle‐kidney crosstalk through microRNA‐29 in chronic kidney disease mouse

Kidney fibrosis is a progressive process that ultimately leads to end‐stage renal failure. Muscle wasting is a serious complication of chronic kidney disease (CKD) and contributes substantially to the morbidity and mortality of patients. Exosomes, natural carriers of many signal molecules including microRNA (miR), mediate organ to organ communication. MiR‐29 has been suggested a therapeutic target for muscle wasting by our studies (Wang JANS 2011), and also has anti‐fibrosis character. We hypothesized that miR‐29 has benefic for both unilateral ureteral obstruction (UUO)‐induced muscle wasting and kidney fibrosis through exosomes‐medicated muscle‐kidney crosstalk.