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[Epidermal thickness and keratinocyte proliferation after cutaneous application of vitamin D].

Using light microscopy, morphometry and immunohistochemistry, the epidermis of 72 male and female rats was examined 1 day and 1 month after the completion of daily cutaneous applications of vitamin D3-containing composition lasting for two weeks. It was found that vitamin D3 causes a statistically significant reduction in the thickness of interfollicular epidermis and in the number of Ki-67 positive keratinocytes. The identified effects persisted for 1 month after the last application of the preparation. Modifying influence of vitamin D3 on the morphogenetic processes in the epidermis, which were manifested, in particular, by a decreased proliferative activity of keratinocytes, is discussed in the light of the data on the possibility of the formation of its active metabolite--calcitriol--directly in the skin.