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Abstract PR176: Dexmedetomidine and Phosphocreatine Posttreatment Provides Protection Against Focal Cerebral Ischemia-Reperfusion Injury in Rats

Materials & Methods: I/R was induced by intraluminal middle cerebral artery occlusion and reperfusion. Male Sprague-Dawley rats were randomly allocated to the Sham group and I/R group. I/R group was further divided into four subgroups: Group I/R, Group D (treated with 9μg.kg-1 dexmedetomidine), Group P (180mg.kg-1 phosphocreatine) and Group C (9μg.kg-1 dexmedetomidine + 180mg.kg-1 phosphocreatine). All treatments were given intravenously immediately at onset of reperfusion at a contant speed of 2 ml.h-1.Twenty-four hours after the reperfusion, neurological deficit score and magnetic resonance scan were performed to confirm successful modeling. Blood samples were taken to measure serum concentrations of malonaldehyde and 4-hydroxynonenal. Brains were harvested to estimate infarct volume and cerebral pathology by optical and electron microscopy. Neuronal apoptosis was further assessed by the expression of cleaved caspase-3 and co-localization of cleaved caspase-3 and NeuN.