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High-Content Screening for the Development of Neuro-Pharmaceuticals The Innovation Network BioSystems Technology

Scientists of the University of Rostock, in cooperation with the enterprises Bionas GmbH, Micronas GmbH, Teraklin AG, and PATTERN EXPERT, are improving test systems for the screening of neuro-active substances. The members of the group have joined forces and collaborate in the consortium "Innovation Network Bio-Systems Technology". The model system is basically characterized by neuronal networks growing on a microchip surface with integrated electrodes. By the introduction of cell culture SOP’s, the development of a refined neuro-chip system with several sensor types, and by the establishment of new active agent classification algorithms an advanced system was created that is now offered for high-content screening which allows quantitative statements and safe classification in an early phase of drug development (Fig. 1).