{'fraction_non_alphanumeric': 0.01818181818181818, 'fraction_numerical': 0.006993006993006993, 'mean_word_length': 4.774193548387097, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Identification of a New Serine Kinase That Activates NFKB by Direct Phosphorylation*

A novel serine kinase, named nuclear factor K B (NFrB) kinase, has been shown to be associated with the NFKB *IKB complex in the cytosol of human primary T lymphocytes. It activates the DNA binding activity of NFKB by directly phosphorylating its p65 and pS0 subunits. There is no evidence that it phosphorylates IrB. Experiments with inhibitors and antisera showed that it is distinct from other known serine kinases such as mitogen-activated protein kinase or Mos. It has an apparent molecular size of 43 kDa determined by the substrate binding assay. This kinase might have a central role in mediating various signals to NFrB.