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[Expression of IGF-IR and COX-2 in renal cell carcinoma and their relationship with cell proliferation].

AIM
To investigate the expression of IGF-IR and COX-2 in renal cell carcinoma(RCC). To explore the correlation among IGF-IR, COX-2 and PCNA expression.


METHODS
Immunohistochemical staining was performed to detect the expression of IGF-IR, COX-2 and PCNA in 64 cases of RCC.


RESULTS
The positive rates of IGF-IR expression and COX-2 expression were 60.9%(39/64) and 51.6%(33/64) in RCC respectively. The expressions of IGF-IR and COX-2 in RCC tissues were not related to the histological type of RCC (P>0.05), but they were related to and increased with the size and clinical stages of RCC (P<0.05). The expression of IGF-IR was related to pathological grades, but COX-2 was not. The expression of IGF-IR was positively related with the expression of COX-2 and PCNA respectively, but there was negative correlation between COX-2 and PCNA.


CONCLUSION
The experiment suggests that IGF-IR and COX-2 may produce a synergetic effect in oncogenesis and progression of RCC. Detection of these genes has positive effects on early diagnosis, malignancy determination, prognosis and treatment of RCC.