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Clinicopathological and genomic copy number variation analysis in nodular hidradenoma and hidradenocarcinoma with focus on prognostically important features.

Nodular hidradenoma is a cutaneous adnexal tumor of sweat gland origin, characterized by its diverse but overlapping histomorphologic features with other skin tumors. In addition, distinction of benign hidradenoma and its malignant counterpart hidradenocarcinoma can be challenging, especially in prognostic prediction. We retrospectively reviewed pathological features of 29 cases, including benign nodular hidradenoma (n=17) and hidradenocarcinoma (n=12), with clinical follow-up ranging 18 to 216 months. Genomic copy number variation (CNV) was studied in selected cases (n=18) by single nucleotide polymorphism (SNP) microarray. None of the benign hidradenomas (0/17) or low-grade hidradenocarcinomas (0/6) had recurrence or metastasis after complete excision, while all 6 high-grade hidradenocarcinomas (6/6) showed locally destructive disease, recurrence, or local metastases. In benign hidradenomas, CNV abnormality was absent in all clear cell hidradenomas (0/5) but was detected in a considerable portion of poroid hidradenoma (3/5), with number of abnormalities ranging 2, 4 and 9. In malignant cases, regardless of morphological classification, both low-grade hidradenocarcinoma demonstrated limited CNV abnormalities in 2 areas (2/2), while all high-grade hidradenocarcinomas contained 8 or more CNV abnormalities (6/6). No disease associated death was recorded in the cohort except one case was lost to follow-up after the development of metastatic disease. Overall, the findings support genomic CNV abnormalities may serve as a sensitive but less specific tool in detecting malignancy in these tumors, and potentially have a role in predicting clinical behavior particularly in the tumors of non-poroid morphology.