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Rapid Detection of Bacterial Response to Antibiotics through Induced Phase Noise of a Resonant Crystal

A new low-cost, multi-channel desktop digital instrument was developed that measures the response of bacteria to multiple antibiotics in about an hour by detecting phase noise induced by mechanical motion of the bacteria when tightly tethered to a resonator. The motivation for this work comes from the approximately 13 million urinary tract infections (UTIs) leading to some 63,000 deaths yearly in the USA and many more worldwide, primarily due to E. Coli and the two-day delay in diagnosing antibiotic resistance. Rapid determination of efficacy could potentially save lives and extend antibiotic lifetimes.