{'fraction_non_alphanumeric': 0.0231809401159047, 'fraction_numerical': 0.014810045074050225, 'mean_word_length': 5.291497975708502, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Effect of High-salt Consumption on Rodent Gut Microbiome: A Meta-Analysis.

The global climate change brings about myriad of changes in the environment and ecosystem. The sea-level rise due to climate change results in salt-water intrusion into freshwater reservoirs of the coastal areas, increasing the salinity of the natural sources of potable water. People in the coastal areas consume saline water, exposing the intestinal tract to higher salt concentration on regular basis. This meta-analysis attempts to relate consumption of saline water to dysbiosis of rodent gut microbiome. Scientific reports were searched in PubMed/Medline, the Cochrane Library and Google Scholar. Original articles, abstracts and short communications were included depending on predetermined inclusion/exclusion criteria. A total of 8 original reports involving 124 rodents were included in this study. The pooled specificity and sensitivity of the reports were found to be 0.833 and 0.891 respectively by Meta Disc software v1.4. Pooled odds ratio and AUC were 20.056 and 0.896 respectively, implying a correlation between increased salt intake and gut microbiome dysbiosis (imbalance), measured from altered Firmicutes: Bacteroidetes ratio. Microbiome dysbiosis makes the intestine prone to enteric diseases. The outcomes of this meta-analysis indicates the dependence of mammalian gut microbiome on the amount of salt ingested, a condition aggravated by the global climate change and therefore necessitates similar studies on human populations living on coastal areas.