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Metabolism of human thyrotropin in the dog.

The metabolism of labeled (131I-hTSH)and unlabeled human thyrotropin (hTSH) has been studied in the dog. Disappearance curves of labeled and unlabeled hormone were shown to be similar. Metabolic clearance rates of mI-hTSH performed by constant infusion in three dogs were 0.97 ± .15 cc⁄min⁄kg. Arteriovenous differences of 131I-hTSH at equilibrium across various organs revealed a significant 5.8‰ difference across the kidney but no significant difference was found across the liver, thyroid or lower extremity. (Endocrinology95:1181, 1974)