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Lipase Catalyzed In Situ Production of Acetaldehyde: A Controllable and Mild Strategy for Multi‐Step Reactions

The set-up of one-pot multi-step processes (domino or cascade reactions) is currently matter of intense research, as these highly integrated one-pot approaches may enable synthetic routes with a significant waste reduction (e.g. by the direct reduction of downstream units). 2] Furthermore, these strategies are also finding a value for the in situ formation of hazardous and volatile substrates (e.g. formaldehyde) needed for a desired synthetic application. For a broad range of synthetic purposes, acetaldehyde might become an excellent reagent or substrate. Yet, its inherent high volatility and reactivity hampers its wider synthetic use, as acetaldehyde is easily prone to react with itself or with other substrates, for example, undergoing aldol condensations, or other undesired competing reactions. Indeed, its use in fields like organocatalysis has been somehow restricted because of that reason, and several approaches for in situ acetaldehyde formation have been reported. In this context, we became interested to assess whether lipases could be used as catalysts for the mild and controllable in situ formation of acetaldehyde. Actually, in non-aqueous media, lipases are wellknown biocatalysts for the enantioselective (dynamic) kinetic resolution of alcohols, amines, etc. , using vinyl esters as acyl donors. In this process acetaldehyde is generated as a by-product (Scheme 1), which often leads to enzyme deactivation