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A placebo‐controlled trial shows no effect of vasopressin on recovery from closed head injury

Vasopressin and its analogues have been claimed to benefit patients with posttraumatic amnesia. To test this hypothesis a double‐blind, placebo‐controlled, prospective trial of vasopressin was carried out in the chronic (rehabilitation) phase of recovery from closed head injury. Seven patients who received vasopressin and 6 who received a placbo were comparable in age, sex, and degree of disability upon entry into the study. Both groups inproved at the same rate in mental status, neurological status, and activities of daily living.