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Interleukin‐13 and interleukin‐13 receptor in Hodgkin's disease: possible autocrine mechanism and involvement in fibrosis

Aims: Hodgkin's disease (HD) is characterized by the presence of Hodgkin and Reed–Sternberg (H–RS) cells against a hyperplastic background of reactive cells such as lymphocytes, histiocytes, plasma cells, eosinophils, neutrophils, and stromal cells. There is ample evidence to suggest that proliferation and survival of HD‐derived cells is due to cytokine signalling. Recently, high expression of interleukin (IL)‐13 was described in HD‐derived cell lines. Here we investigated the possible involvement of IL‐13 in the pathophysiology, especially autocrine pathways of H–RS cells.