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Study for noninvasive determination of optical properties of bio-tissue using spatially resolved diffuse reflectance

The optical characteristics of absorption and scattering of irradiated tissue determine light spatial distribution and the subsequent biological effects, which could decide the dosimetry for laser medical applications. Studys have shown that the optical properties of bio-tissue could be determined through some fitting algorithms with spatially resolved diffuse reflectance theory based on the measurement of diffuse reflectance. The regression of reflectance data with by diffusion theory model was important for optical properties estimation. In the paper, the reflectance versus distance data acquired from Monte Carlo method was by fit to diffusion theory model by the nonliear least-squares fitting algorithm to study the produre and mothod of determination of optical properties. And attention was especially paid to the influence of the radial step width Δr, length of radial distance rL and start value of radial distance r0 on the regression results. Preliminary results indicated that the radial step width and length of radial distance rL both have little influence on the fitting. Nevertheless, the start value of radial distance r0 of reflectance data has great influence on the fitting. Fitting deviation would become little while the start value of radial distance r0 grow greater. and an appropriate r0 was important for data fitting. Study also showd a more accurate light diffuse reflectance theoretical model was need for estimate the optical parameters by fitting the diffuse reflectance data accurately. Our work maybe be helpful to the experiment measurement of light diffuse reflectance data for noninvasive optical properties determination.