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Dialysis-related amyloidosis of the tongue.

Dialysis-related amyloidosis (DRA) is a serious complication occurring most commonly in patients undergoing long-term hemodialysis and in patients with renal replacement therapy.1-4 The deposition of amyloid, which consists of beta2-microglobulin (beta2m), is a major contributing factor in DRA and preferentially involves bone and joint structures, presenting as carpal tunnel syndrome, destructive arthropathy, spondyloarthropathy, and subchondral bone erosion and cysts.1,2,5 As the number of long-term hemodialysis patients has increased, amyloid deposits have been found very occasionally in various extraosteoarticular organs, such as skin, liver, heart, spleen, kidney, and the gastrointestinal tract, following the onset of osteoarticular DRA.1,6 Dialysis-related amyloidosis of the tongue has rarely been reported, but may cause serious lingual dysfunction affecting the patient’s quality of life.3,7-12 We describe a rare case of lingual DRA in a longterm hemodialysis patient for whom dialysis treatment using a Lixelle column (Kaneka Co, Osaka, Japan) has been useful in decreasing the circulating beta2m levels.