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Cyber-Physical System for Donor Organs' Rejection Risks Prevention Based on Donor and Recipient Health Monitoring

Today in Ukraine the problem of transplantation of organs and other anatomical materials to humans is very acute. Among the reasons hindering the development of transplantation of anatomical materials to humans in Ukraine is the rejection of donor organs by the recipient's body. The dependences of the process of rejection of donor organs by the recipient's body on the different surface structures of cells in the recipient and donor, on the incompatibility of recipient and donor on HLA antigens, on the level of dangerous antibodies in the recipient's body, on consideration of only the waiting time for the distribution of donor organs, on the origin of the donor organ (cadaveric organ or organ from a living donor), on the general health of the recipient, on the age of the donor, on the gender of the recipient, on the recipient's disease and its phase, which required transplantation, on the chosen type of immunosuppressive therapy, and on the presence of progressive chronic dysfunction of the transplanted organ. The established dependencies are useful in the selection of donor organs in order to minimize the risk of rejection of organs by the recipient. Rules and method for supporting the decision on the possibility or undesirableness of donation and transplantation, taking into account the risks of rejection of donor organs, have been developed. The architecture of the cyber-physical system for donor organs' rejection risks prevention based on donor and recipient health monitoring is developed, aimed at verifying the existing list of factors of donor organ rejection. Based on this test, the developed cyber-physical system offers a conclusion on the possibility (if all donor organ rejection factors are eliminated or minimized) or undesirableness (if one or a group of donor organ rejection factors cannot be eliminated) of donation and transplantation in a given case.