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The effect of oxidized regenerated cellulose on experimental intravascular infection.

Two groups of dogs had aortotomies and insertion of a Teflon patch. One group had the area of the aorta with the patch wrapped with oxidized regenerated cellulose (ORC); the other group served as a control. Both groups of animals were infected with S. aureus intravenously immediately after removal of the aortic clamps. The animals which had ORC wrapping of the aorta had significantly lower bacterial counts at the time of death than did the untreated group. This was measured from an hour after challenge up to 30 days.