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A Study of the spectrum of Urinary Tract infections in patients with Adult Polycystic Kidney Disease – An old problem with a better outcome

Background: Autosomal Dominant Polycystic kidney disease (ADPKD) is the most common hereditary cause of End stage renal disease (ESRD). Urinary tract Infections (UTI) are common in these patients and include a spectrum of both Lower tract and upper tract UTI. Methods: This retrospective study which included patients of ADPKD who manifested UTI between June 2012 to May 2017. Clinical, Laboratory, imaging and microbiological data was analyzed. Few patients had more than one episode of UTI and there by the total number of UTI episodes were 52.Out of the 58 episodes of UTI, Lower tract UTI and Upper tract UTIs were 13 and 45 episodes. Among the total 45 episodes of upper UTI, 17 were Acute Pyelonephritis and 28 were Cyst infections. 40 % of UTI episodes necessitated Hospitalization. Conclusions: Cyst infection is the most common form of UTI followed by acute pyelonephritis and Lower tract UTI. Majority of the UTI episodes were caused by E.coli. Around 40 % of patients with UTI mandated hospitalization but no episode of death attributable to UTI was noted.