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[Effect of Deposiston on hormone secretion of the renin-aldosterone system, the adrenal cortex and the pituitary - ovary system].

Effects of Deposiston a combination contraceptive on the renin-angiotensin-aldosterone system the hypophyseal-ovarian system and the adrenal system are studied. Blood hormone parameters in 25 healthy women (24-42 years old) were assayed before Deposiston use 3-6 days after use and after 2-3 cycles of Deposiston. Aldosterone was increased after 3-6 days and still pronounced (2 times normal) after 2-3 cycles. Renin activity increased (2 times normal) after 3-6 days and was 3 times normal after 2-3 cycles. Cortisol increased from 10.4 to 20.1 ng/100 ml. Estradiol decreased to about 1/3 its normal level and was characteristic for anovulatory cycles. LH decreased to the lowest level of normal. Results of all parameters were comparable to those of other authors where different hormonal contraceptives were used. Although there is a causal relationship between aldosterone levels and hypertension there is only a small percentage of biologically-available aldosterone; the rest is bound to aldosterone-binding globulin. The physiology of renal chemo and baroreceptors maintains renin homeostasis. Cortisol biological availability remains low since estrogens stimulate cortisol-binding globulin. Suppression of estradiol levels prevents follicle maturation. Effectiveness of contraceptive agents can be monitored by the lack of an LH-peak; this and the suppression of estradiol show Deposiston to be equally effective and reliable as traditional estrogen-progestin agents. Although Deposiston can promote hypertension such occurrences are rare. Continued monitoring is indicated and Deposiston is contraindicated in patients with existing hypertension diabetes mellitus or a familial disposition to either of these diseases.