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[Ultrastructural and radioautographic research on the skin in acantholysis bullosa].

By means of light microscopy 145 biopsies of skin in acantholytic pemphigus were studied. Electron microscopic and radioautographic study was carried out in 19 cases. It was determined that the whole complex of ultrastructural changes in epidermocytes (impairment of nucleolar apparatus, lysis of cytoplasmic organelles, disappearance of desmosomes) reflects the disturbance of protein synthesis. Radioautographic study in vitro with 3H-uridine and 3H-thymidine revealed the low level of RNA and DNA synthesis in epidermal cells in pemphigus. The data obtained were interpreted with a position from the conception of plastic deficiency.