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Photodynamic biologic tissue glue in perforating rabbit corneal wounds.

OBJECTIVE
To evaluate the in vivo wound modulating effects of a new biologic tissue adhesive.


BACKGROUND DATA
Biological tissue glue can serve as an important adjunct technology in the treatment of a number of ocular conditions, including closure of corneal wounds. These experiments were performed to evaluate the wound healing effects of a new photodynamic biologic tissue glue (PBTG) in perforating rabbit corneal incisions.


METHODS
Perforating corneal wounds were created in 12 pigmented rabbits. Two perforating incisions were made 180 degrees apart 2 mm from the limbus. One incision in each eye was closed with a single interrupted 10-0 nylon suture, and the other closed with PBTG. Rabbits were followed biomicroscopically and sacrificed at 1-, 3-, and 7-week intervals for histological evaluation of their corneal wounds.


RESULTS
There were no clinical signs of PBTG-related toxicity in any of the rabbits. Compared to control wounds, all glued corneas had greater epithelial filling, less stromal edema, and fewer inflammatory cells at the 1-, 3-, and 7-week stages and showed greater overall wound maturation.


CONCLUSION
Our data suggest that PBTG is an effective and nontoxic tissue adhesive that accelerates normal corneal wound healing.