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Ventricular interaction quantified with a novel multi‐scale cardiovascular model

Ventricular interaction (VI) in the heart is the influence of function of one ventricle on the other. To investigate VI, a novel multi‐scale model of the canine cardiovascular system was developed. Multiple beats of a normal heart were simulated, followed by pulmonary artery constriction (PAC). VI was quantified by computing ventricular co‐compliances, i.e. the volumic changes in each ventricle due to a pressure change in the other ventricle (CRL = dVR/dPL and CLR = dVL/dPR). CLR and CRL varied throughout the cardiac cycles. After PAC, diastolic values changed acutely from –5.7 to –6.5 ml/mmHg, due to an abrupt change in VI. The model is likely to be useful in investigating VI, among others, in many clinical settings. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)