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AOVSM Posters Abstracts

Purpose: To explore the relationship between ocular surface sensitivity, symptoms of dryness and discomfort, and dry eye parameters. Methods: Central corneal sensitivity (CCS) and inferior conjunctival sensitivity (ICJS) were measured using a Cochet Bonnet esthesiometer (0.08-mm-diameter thread) on 36 normal subjects (27F : 9M, 38 ± 14 years). The subjects completed the Ocular Comfort Index (OCI) questionnaire. Dry eye parameters (tear osmolarity, Phenol red thread, tear break-up time, fluorescein and lissamine green corneal and inferior conjunctival staining, and Meibomian glands) were assessed on a single visit. Associations were assessed using Spearman or Pearson correlation tests, where appropriate. Results: CCS only was associated with frequency of the dryness and tiredness symptoms (r = −0.34, P < 0.05, r = −0.29, P < 0.05, respectively) but not the total OCI score. Lissamine green staining of the inferior conjunctiva was significantly associated with ICJS (r = 0.21, P < 0.05). The total symptom score for OCI was associated with tear osmolarity (r = 0.38, P < 0.01). Conclusion: The symptom of ocular dryness, as measured using the OCI, is associated with lower CCS in a normal population. Tear osmolarity, which is a key indicator of ocular surface status, is associated with the total OCI symptom score.