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ULTRASTRUCTURE OF THE EPIDERMIS

The structure of mammalian epidermis has been of considerable interest to investigators concerned with aspects of its synthesis of keratin, as well as with its neoplastic and other pathological changes. With the development of techniques for the examination of tissue sections with the electron microscope, several electron microscopic observations of skin have been reported (1-8), but no comprehensive studies of mammalian epidermis, employing the techniques currently regarded as optimum, have yet appeared. The present study was designed, therefore, to use recently established methods of thin sectioning and electron microscopy to extend the knowledge of certain features of the cytology of mammalian epidermis to the submicroscopic and macromolecular level.