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The Relation of Plasma Endothelin Levels and Albumin Excretion Rate in Microalbuminuric Type 2 Diabetic Patients

Objective: In a selected group of type 2 diabetic patients with microalbuminuria,we investigated plasma endothelin (ET) levels compared to a normal albuminuria group of type 2 diabetic patients and verified whether there is a relationship between endothelin levels and albumin excretion rate in type 2 diabetics. Methods: Forty-six type 2 diabetic patients without hypertension or nephitis and urinary tract infection were selected. They were divided into two groups,normal albuminuria group and microalbuminuria group. Blood pressure,fasting plasma glucose,glycosilated hemoglobin(HbA_ 1c ),serum creatinine,serum cholesterol,serum triglyceride,urinary albumin excretion rate and plasma ET levels were measured. Mean ET values in two groups of type 2 diabetic patients were compared using Student's t-test. Linear regression test was done to relate two variables. Results: Mean ET values were significantly higher in the microalbuminuria group than in normal albuminuria group (92.1±26.9 pg/ml vs 50.8±7.6 pg/ml;P0.01). No relationship was found between plasma ET level and blood pressure,serum creatinine,serum cholesterol,serum triglyceride and HbA_ 1c in the microalbuminuria group. There was a significant positive correlation between plasma ET levels and albumin excretion rate in the microalbuminuria group (r=0.512;P0.05). Conclusion: Our results showed that plasma ET values were increased in microalbuminuric,normotensive,type 2 diabetic patients and correlated with albumin excretion rate. These findings confirmed that endothelial dysfunction,as expressed by ET levels,occurred early in these patients and supported the hypothesis of a potential role for this peptide in development of microalbuminuria in diabetic nephropathy.