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Escherichia coli Endotoxin Effect on a Methylcholanthrene-lnduced Sarcoma in the Hamster Cheekpouch 1

Summary Golden hamsters, Mesocrice-tus auratus, were transplanted in their cheekpouches with 105 methylcholanthrene-induced sarcoma cells maintained in tissue culture. At varying times the animals were injected intraperitoneally with a single dose of E. coli endotoxin and the tumors were observed periodically for damage. Animals treated with endotoxin on Days 4 through 8 after tumor transplantation exhibited hemorrhaging adjacent to the tumor nodule, hemorrhaging within the tumor, decreased tumor growth rate, and, in a quarter of cases, necrosis of the tumor. Normal tissue transplants did not exhibit these effects. It appears that the hamster cheek-pouch may be a useful model for the study of endotoxin effects on young tumors.