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The selective localization of B lymphocytes in the spleen and the role of complement receptors

The role of complement receptors on the localization of T and B cells in the spleen of mice was studied using short‐term homing experiments in cobra venom factor (CoF)‐ treated animals. The localization ratio of B and T cells in the spleen of CoF‐treated mice decreased significantly compared to control recipients. No changes could be found in the relative distribution of resident T and B cells in the spleen or other lymphoid organs of CoF‐treated animals and when their spleen or lymph node cells were transferred, the localization pattern was normal. When cells were incubated in serum prior to transfer a disturbed localization ratio in the spleen of untreated recipients was observed. This was due to a blockade of complement receptors as determined by the inability of the incubated cells to form EAC rosettes. No blockade of EAC rosettes and no changes in localization ratios upon transfer could be observed when the cells were incubated in functionally C3‐depleted serum. The results suggest a role for the complement‐receptor on B cells in the initial localization in the spleen, whereas no influence upon the selective localization in high endothelial venules‐ bearing organs was found.