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Is long‐term humoral immunity in the mucosa provided by long‐lived plasma cells? A question still open

The biology of antibody‐secreting cells is still a matter of controversial discussion. One of the key questions is how the migration and lifespan of antibody‐secreting cells is linked to their generation. A paper in this issue of the European Journal of Immunology provides further information on the generation of long‐term mucosal immune responses; however, the study leaves many questions unanswered as discussed in this brief Commentary.