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VARICELLA LIKE DERMATOLOGICAL MANIFESTATION FOLLOWING SARSCOVID-19 INFECTION :A DIAGNOSTIC DILEMMA

The infection caused by the novel SARS-CoV-2 is a public health
emergency of international concern. Although, COVID-19, mainly
affects the lungs, the infection can spread to extrapulmonary tissues,
causing multiorgan involvement in severely ill patients. The
infectivity of SARS-CoV-2 is related to the pattern of expression of the
viral entry factors ACE2 and TMPRSS2 in human tissues. As such, the
respiratory and gastrointestinal tracts are at high risk for SARS-CoV-2
infection due to their high expression of ACE2 and TMPRSS2, which
explains the clinical phenotype described in the vast majority of
infected patients that includes pneumonia and diarrhea. Recently,
concern regarding virus to infect the skin has been raised by
dermatologists due to the increasing observations of cutaneous
manifestations in patients with SARS-CoV-2 infection. Although there
is little evidence of the expression of ACE2 and TMPRSS2 in the
normal skin, the dermatological ndings observed among COVID-19
patients warrants further investigation to delineate the mechanisms of
skin affection after SARS-CoV-2 infection[1]. The frequency of skin
lesions in these patients varies between 1.8 % and 20.4 % . The major
dermatologic morphologies described in CoVID-19 cases were
morbilliform, pernio-like, urticaria, macular erythema, vesicle,
papulosquamous and retiform purpura