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The Haemoglobin Constitution of Infants with the Haemoglobin Bart's Hydrops Foetalis Syndrome

Summary. The haemoglobin constitution of 14 infants with the haemoglobin Bart's hydrops syndrome has been examined. Thirteen of the infants were stillborn or lived only a few minutes after delivery, but in one case an exchange transfusion was performed and the pattern of globin chain synthesis examined by an [H3]leucine incorporation experiment utilizing umbilical cord blood. These studies indicate that the syndrome results from a total deficiency of α‐chain production. Furthermore, it has been possible to exclude the presence of fragments of α‐chain longer than II residues in the cells of these infants.