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Evident, but poorly defined: left ventricular hypertrabeculation/noncompaction and its diagnostic criteria.

We read with interest the article by Murphy et al. 1 about the natural history and familial characteristics of left ventricular hypertrabeculation/noncompaction (LVHT). In 45 patients with LVHT, they observed a survival from death or transplantation of 97% and conclude that LVHT is associated with a better prognosis than previously reported.

That LVHT is a disorder of endomyocardial morphogenesis, as stated by the authors, is only one of several hypotheses. Actually, the etiology of LVHT is not known. Arguments against the ‘embryonal’ hypothesis are patients in whom LVHT developed during life: three members of a family who subsequently developed LVHT did not show LVHT-characteristic …