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Insulin-induced hypertrophic lipodystrophy.

Localized asymptomatic soft tissue swellings developed in a 20-year-old woman, Type I juvenile-onset diabetic, at the site of repeated insulin injections. Histopathologic examination of specimens from these lesions in three patients showed chronic inflammatory changes and exogenous foreign material that was thought to be silicon. Lipodystrophic changes associated with insulin therapy are briefly reviewed.