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Augmentation With Modafinil to Achieve Remission in Depression: A Case Report.

Sir: Depression, with a prevalence rate from 4.8% to 9.2%, is a common illness treated by family physicians.1 Over the last 20 years, a number of antidepressants have become available for physicians to treat patients with depression. Approximately 50% to 60% of patients will respond to treatment2; however, only about half of those patients responding to treatment will achieve remission.3 Clinicians are then left to treat a large number of patients who have responded to initial treatment but continue to experience depressive symptoms that interfere with their level of functioning. A case is presented of a patient diagnosed with depression, taking 2 antidepressants, who had previously failed augmentation with lithium and levothyroxine, but achieved remission with the addition of modafinil.