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THE IMMUNOCYTOCHEMICAL DEMONSTRATION OF CATHEPSIN D

Cathepsin D has been demonstrated for the first time using an immunocytochemical approach and fluorescence microscopy. It has been localized in chick epithelium-like cells and in cells of synovia from joints of rabbits with an experimental arthritis. The enzyme is associated with lysosome-like organelles: it also has a diffuse cytoplasmic distribution in these cells.