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Plasma total coenzyme Q9 (CoQ9) in the New Zealand population: reference interval and biological variation.

Coenzyme Q9 (CoQ9) in human plasma may originate as a product of incomplete CoQ10 biosynthesis or from the diet. The estimated dietary CoQ9 intake is 0–1.3 μmol/day, primarily from cereals and fats (1)(2), but this is unreliable because many food items contain levels below the detection limit (1).

Some methods for estimating human plasma CoQ10 use CoQ9 as an internal standard; thus, intraindividual variation in the concentration of endogenous CoQ9 is a potential source of error.

We measured total CoQ9 in human plasma, determined a reference interval, examined the biological variation, and documented the influence of CoQ10 supplementation on plasma CoQ9 concentrations.

Self-reportedly healthy volunteers (n = 193; men/women, 82/113) were enrolled for determination of a reference interval for CoQ9. Mean age of participants was 45 years (range 18–82). No participants reported taking CoQ10 supplements.

Biological variation of CoQ9 was determined in healthy adult male volunteers …