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Restoration of the Ovarian Response to Gonadotropins in Patients After Molar Abortion

The recovery of the ovarian response to gonadotropin stimulation after molar abortion was investigated in relation to the serum human chorionic gonadotropin (hCG) level. Thirteen women with an aborted mole were given 225 IU of human menopausal gonadotropin (hMG) per day for 3 consecutive days, and their serum levels of estradiol (E2) were determined by radioimmunoassay on days 1, 3, 5, and 7 after hMG administration. Women with serum hCG levels of less than 2000 mlU/ml exhibited a normal increase in serum E2 levels in response to hMG, whereas women with serum hCG levels of 2000 mlU/ml or more did not show any change after hMG administration. These findings suggest that a serum level of hCG in excess of 2000 mlU/ml prevents normal ovarian E2 responsiveness to exogenous gonadotropin stimulation.