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Neuron Survival Without Retrograde Transport

Some neurons depend on signals from their environment for their survival. In particular, sympathetic neurons are supported by nerve growth factor (NGF) that is secreted by their targets. Previous observations have indicated that NGF was internalized and transported back to the neuronal cell body. Using NGF anchored to beads, MacInnis and Campenot (see the Perspective by Miller and Kaplan) now show that although sympathetic rat neurons in compartmentalized culture do require NGF for survival, their survival does not require that NGF be internalized and transported. B. L. MacInnis, R. B. Campenot, Retrograde support of neuronal survival without retrograde transport of nerve growth factor. Science 295, 1536-1539 (2002). [Abstract] [Full Text] F. D. Miller, D. R. Kaplan, TRK makes the retrograde. Science 295, 1471-1473 (2002). [Full Text]