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Application Of Diffuse Energy Transfer To Dosimetry In Photodynamic Therapy

This approach to optical dosimetry in photodynamic therapy is based on the hypothesis that tumor eradication requires a minimum absorbed energy density by tissue-localized hematoporphyrin derivative. The required incident fluence is calculated from absorption profiles based on the diffusion approximation to radiative transfer. The results are in satisfactory agreement with empirical light dose levels reported in the clinical literature.