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A Scintigraphic Study of the Deposition of Artificial Surfactant Exosurf in the Guinea‐pig

The deposition and clearance of an artificial pulmonary surfactant preparation (Exosurf) has been studied using gamma scintigraphy in the anaesthetized guinea‐pig. The lipid phase of the formulation was radiolabelled by the incorporation of [99mTc]hexakis (t‐butyl isonitrile) (TBIN); the aqueous phase by [113mIn]InCl3. The formulation was administered by intratracheal lavage and compared with the whole‐lung image obtained following administration of 133Xe gas. Pulmonary inflation pressure and arterial pressure were monitored throughout the experiment.