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Targeting serotonin synthesis to treat irritable bowel syndrome.

Serotonin (5-hydrodytryptamine; 5-HT) is an important signaling molecule in the gastrointestinal (GI) ract, where it is predominantly produced in the enterohromaffin (EC) cells in the mucosa, and also by a subopulation of enteric neurons.1 In the brain, 5-HT is a neurotransmitter that plays a pivotal role in the regulation of mood and cognition. Animal studies revealed that 5-HT, released from EC cells and interneurons, is involved in the control of GI secretion, motility, and visceral perception.1 5-HT is synthesized through the actions of the ate-limiting enzyme tryptophan hydroxylase (TpH), of