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SPECIAL REPORT Endothelium‐dependent relaxation to the B1 kinin receptor agonist des‐Arg ‐bradykinin in human coronary arteries

Des‐Arg9‐bradykinin (des‐Arg9‐BK) caused endothelium‐dependent relaxations in human, isolated coronary arteries which upregulated with in vitro incubation time. Relaxations to des‐Arg9‐BK were inhibited by the B1 receptor antagonist, des‐Arg9‐[Leu8]‐BK (pKB, 6.14 ± 0.11) but were unaffected by the B2 receptor antagonist, Hoe‐140. Therefore, this is the first demonstration that human coronary arteries possess endothelial B1 receptors which mediate endothelium‐dependent relaxation and appear to be synthesized de novo during the incubation period.