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Current Evidence and Applications of Photodynamic Therapy in Dermatology: Part 1 Cutaneous Neoplasms

ABSTRACT Photodynamic therapy (PDT) involves the activation of a topical photosensitizing drug with exposure to a light source. Commonly used agents in PDT include 5-aminolevulinic acid and methyl aminolevulinic acid. These medications preferentially localize to diseased skin, resulting in selective cytotoxic damage and immunomodulation. In addition to the advantages of PDT as being noninvasive and capable of field treatment, PDT has also been associated with reduced recovery time and improved cosmetic results. This article is Part 1 of a two-part series reviewing the state of current evidence and applications of PDT in dermatology. Part 1 will address PDT as treatment for cutaneous neoplasms, namely, actinic keratosis and nonmelanoma skin cancers. Part 2 will follow with a discussion of more recent indications for PDT in dermatology, such as acne and photorejuvenation.