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[Possibilities of mathematical models of pharmacokinetics].

Mathematical modelling is currently the most rapidly developing branch of pharmacokinetics. Along with such traditional pharmacokinetic aspects as drug absorption, distribution, metabolism, and elimination, the pharmacodynamic area is also becoming actively involved in mathematical modelling. Complex pharmacokinetic-dynamic models are becoming a tool that finds wider application in drug therapy optimization. Current approaches to the pharmacokinetic modeling are discussed and classification of various model types presented, each type being briefly specified and compared to the others. Mention is made of the major problems that are encountered in pharmacokinetics and that require modelling to find a proper solution. Future tasks calling for the use of modelling are also considered.