{'fraction_non_alphanumeric': 0.01806083650190114, 'fraction_numerical': 0.008555133079847909, 'mean_word_length': 5.460122699386503, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Respiratory effects of pethidine and pentazocine during trichloroethylene anaesthesia.

SUMMARY To control tachypnoea during nitrous oxide, oxygen and trichloroethylene anaesthesia, pethidine (mean dose of 344 mg) or pentazocine (mean dose 38 mg1) was given intravenously. The dose (mg) of the two drugs needed for the effective control of tachypnoea approximated the peak respiratory rate. This produced a reduction of pH and rise in Pa0o25 the changes being more marked after pentazocine. Both drugs caused a reduction in respiratory rate and minute volume but an increase in tidal volume comparable to the control values was seen only with pethidine. Since, at identical weights, pethidine has only one-third of the respiratory depressant effect of pentazocine, the two drugs may be acting differently to control the tachypnoea. Pethidine may be controlling the tachypnoea both by central depression and by interfering with the afferents from pulmonary stretch receptors, while pentazocine may be acting directly by depressing the respiratory centre