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[Relationship between dehydroepiandrosterone and arteriosclerosis in premenopausal and postmenopausal women].

OBJECTIVE
To investigate the correlation between dehydroepiandrosterone and arteriosclerosis in premenopausal and postmenopausal women.


METHODS
Forty premenopausal and 40 postmenopausal women were examined for serum concentrations of dehydroepiandrosterone and intima-media thickness of the carotid artery, and the serum concentrations of lipids, estrogen, endothelin, and E-selectin were also measured.


RESULTS
Compared with premenopausal women, the mean intima-media thickness was increased but dehydroepiandrosterone and estrogen levels were decreased in postmenopausal women. A significant inverse correlation was detected between the intima-media thicknesses and dehydroepiandrosterone level. The postmenopausal women had decreased antioxidation and elevated low-density lipoprotein level.


CONCLUSION
Arteriosclerosis is more likely to occur in women with low dehydroepiandrosterone level which causes decreased antioxidation and elevation of blood lipid levels.