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Alterations in β‐catenin expression and localization in prostate cancer

Wnt signaling is thought to be important in prostate cancer, in part because proteins such as β‐catenin can also affect androgen receptor signaling. β‐Catenin forms a cell adhesion complex with E‐cadherin raising the possibility that loss of expression or a change in β‐catenin distribution in the cell could also alter downstream signaling, decreased inter‐cellular adhesion and the promotion of metastasis. A number of studies have reported the altered expression and/or localization of β‐catenin as a biomarker in prostate cancer.