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Granulocyte response in vitro to isoproterenol, histamine, and prostaglandin E1, during treatment with beta-adrenergic aerosols in asthma.

We previously reported that isoproterenol (ISO) inhibition of in vitro granulocyte (PMN) zymosan-induced lysosomal enzyme beta-glucuronidase release is decreased in asthma. To determine whether the regular administration of beta-adrenergic sympathomimetics in the treatment of asthma affected this abnormality, this PMN response to ISO was measured serially in a group of 11 asthmatics who received aerosols of ISO (600 µg per day) or albuterol (680 µg per day) for 12 wk. The maximal bronchodilator response to beta-adrenergic aerosols was unchanged during the study period. ISO (1.0 µ M to 100 µ M) inhibition of PMN lysosomal enzyme release was significantly impaired after the patients received either aerosol sympathomimetic for 4 wk, and the change in PMN response to ISO was most evident at this time. Impairment in PMN response to ISO was also significantly decreased in its ability to stimulate formation of cyclic adenosine monophosphate. The impaired ISO response persisted during the next 8 wk. In addition, ...