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[Carrier detection in Duchenne/Becker muscular dystrophy in the families in which the DNA of the affected person is not available].

INTRODUCTION
Duchenne muscular dystrophy (DMD) is a severe, progressive, X-linked muscular disease, which affects 1 in 3500 male newborns. The course of the other allelic form of the disease (Becker muscular dystrophy--BMD) is milder. Female relatives of affected subjects may carry the mutated gene.


AIM OF THE STUDY
The purpose of this study was to detect the carrier among 23 families affected with DMD/BMD, in whom DNA from the deceased affected person was not available.


MATERIAL AND METHODS
The analysis of polymorphic sequences within the dystrophin gene was applied.


RESULTS
Informative results were obtained in 26 of 39 females examined (66%): 7 females were found to be carriers and 19 noncarriers. In one family the deletion could be detected in the mother and sister of the deceased proband.