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Medication That Treats Chronic Dry Eyes and Increase Tears Production

Cyclosporine is a cyclic polypeptide of 11 amino acids. It is produced by a fungal species which has immune-suppressive properties. It shows specific action on T cells and the cellular immune response.

Dry eye is a condition in which a person doesn’t have enough tears that lubricate and nourish the eye. It is a condition caused by inflammation of eyes. Tears play an important role to maintain the health of the front surface of the eyes. It also helps to provide clear vision and reduce the risk of infection etc. Many vital functions are done by the tears. Dry eyes occur when the balance between the production and drainage of tear is disturbed.

Cyclosporine is an ophthalmic solution used to increase tear production in people with dry eye disease. It was approved by FDA in January 2003.


How does dose Cyclosporine work?

Cyclosporine belongs to the class of medications known as immune-suppressants. It helps to increase tear production in people with dry eye disease. It decreases swelling in the eye to allow the production of tears.

The solutions is thought to work locally in the eyes as a partial modulator of the immune system. A lymphocyte is a type of white blood cell of the immune system. A condition may occur where these cells may die and accumulate in the tear glands. Cyclosporine can reserve this condition and lead to increase in tear production. The treatment may take 3 to 6 months to shows increase in tears production.

What are the uses of cyclosporine?

  1. Cyclosporine is an immune-suppressive agent. It helps to treat chronic dry eyes that may be caused due to inflammation.
  2. Helps patient increase their eye’s natural ability to produce tears.
  3. Can help reverse a worsening dry eye.
  4. Allows your eye to produce the maximum amount of tears that it is capable of producing.
  5. It is very safe and won’t penetrate into the bloodstream to any significant levels.
  6. The medication may be prescribed for other uses ask your doctor for more information.

How to use the ophthalmic Cyclosporine?

Cyclosporine is available in the form of an ophthalmic solution of 3 ml bottles (strength 0.05%).

  • General Dose: – One drop of the above solution two times a day in each eye at a difference of 12 hours.
  • Children: – Safety and efficiency not established in the age group below 16 years.


  • It can be used with artificial tears allowing a 15-minute interval between products.
  • Use the drop at around the same times every day.
  • It comes in small bottles to be used for one dose.
  • Close your eyes for 2 minutes after installation.

What are the precautions in using Cyclosporine?

  1. Some important instruction has to be followed while using cyclosporine. Inform or ask your doctor if you are/ have.
  • Eye infection.
  • Punctal plug in your eye.
  • Herpes infection of the eye.
  • Pregnant.
  • Breastfeeding.
  • Allergic to Cyclosporine or any other medicine.
  1. Remove your contact lenses before installing Cyclosporine. Put them back 15 minutes later.
  2. Don’t use in a patient younger than 16 years of age.
  3. Close your eyes for 2 minutes.
  4. Inform your doctor about other drugs you take or other eye drops to avoid drugs interaction.
  5. Your eyes may sting or burn for a short time. It is normal. Inform your doctor if the condition persists for a long time.

Cost of cyclosporine (generic & brand).

Generic medicines does not need to spend much on research and development of the drug. Other costs like the commission to agents etc. are also saved due to direct sourcing from the manufacturer. Another cost-cutting method allows us to sell cheap generic medicine to our customers.

Brand drugs include cost spend on advertising packaging and pricing. It also spends a lot of amounts on advertising their brand name. So the brand medicine is always costlier.

Cost of Generic Cyclosporine.

1 Bottle of 3 ml of 0.05 % of Cyclosporine cost $ 24.

Cost of Brand sandimmune.

1 ampule of 5 ml (50 mg/ml) costs $ 64.80.