Urtica dioica (stinging nettle root)

Urtica dioica, also called stinging nettle root, can help to support the natural testosterone production by making sure the testosterone molecule does not bind to the SHBG transport protein (Sex Hormone Binding Globulin) (1). As the SHBG helps to let free testosterone circulate longer in the blood, it prevents free testosterone from binding to certain receptors in the muscle cells. By blocking the interaction between free testosterone and SHBG, higher levels of free testosterone are available in the body, which can lead to increased muscle growth.

Urtica dioica contains 3,4-divanillyltetrahydrofuran, which has a direct influence on natural testosterone production (1).

Urtica dioica

Furthermore, Urtica dioica also helps to block the conversion of testosterone into DHT (2)(3).

Urtica dioica is used as a key ingredient in SynTest PM.

syntest saw palmetto

Schöttner M, Gansser D, Spiteller G. “ Interaction of lignans with human sex hormone binding globulin (SHBG) ”. Z Naturforsch [C]. 1997 Nov–Dec; 52(11–12): 834–43

Safarinejad MR. “ Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study ”. J Herb Pharmacother.. 2005;5(4): 1-11.3

Lopatkin N, Sivkov A, Walther C, Schlafke S, Medvedev A, Avdeichuk J, Golubev G, Melnik K, Elenberger N, Engelmann U. “ Long-term efficacy and safety of a combination of sabal and urtica extract for lower urinary tract symptoms: a placebo-controlled, double-blind, multi-center trial ”. World Journal of Urology. 2005, June 1