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PXD010878 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDT2216 is a specific BCL-XL PROTAC
DescriptionTo validate the specificity of DT2216, we used the stable isotope labeling with amino acids in cell culture (SILAC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics to analyze the changes in proteins in WI-38 normal human diploid fibroblasts after DT2216 and DT2216NC treatment. The results show that DT2216, but not DT2216NC, reduced the levels of BCL-XL, but none of other proteins were significantly affected by either agent, demonstrating that DT2216 is a specific BCL-XL PROTAC.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDongwen Lv
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-08-28 01:27:57ID requested
12019-10-08 07:04:21announced
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biological
submitter keyword: DT2216 Bcl-xl PROTAC SILAC LC-MS/MS
Contact List
Daohong Zhou
contact affiliationDepartment of Pharmacodynamics, University of Florida
contact emailzhoudaohong@cop.ufl.edu
lab head
Dongwen Lv
contact affiliationUniversity of Florida
contact emaillyu.dongwen@cop.ufl.edu
dataset submitter
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PRIDE project URI
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