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Noopept: The Common Side Effects and Reactions | Schiz Life

Noopept: The Common Side Effects and Reactions | Schiz Life

Nootropics are smart drugs or cognitive enhancers. They are a class of supplements and drugs that enhance cognitive function, motivation, and creativity in healthy individuals. Even though the manufacturers claim nootropics improve cognitive function, research is still in the early stages, and the effects of most these substances are yet to be fully understood. Noopept is one of the most common nootropics.

The use of cognitive enhancers like Noopept by healthy people in the absence of an underlying medical condition is controversial and spans many issues like fairness and ethics of use, concerns over side effects, and diversion of prescription drugs for nonmedical use. The sale of these smart drugs is a growing industry. Before taking Noopept, it is vital you understand how it works. This article highlights what Noopept is, the benefits, the side effects, and adverse reactions.


What Is Noopept? 

Noopept is a nootropic supplement derived from the racetam drug family. It is a cognitive enhancer, but its efficacy is questionable. Noopept is considered the best nootropic and is one of the most powerful cognitive enhancement drugs. Chemically, it is a hydrophilic proline. It also has a dipeptide structure and is considered a very strong racetam since it has a dipeptide analog of piracetam, but thought to be 1000 times stronger.

Noopept is unique in its functions as a prodrug. When you ingest the supplement, it won't appear in the serum. Even though the pharmacodynamics of the drug are not fully elucidated, it is thought to act as a modulator for brain receptors and optimizes the transmission of acetylcholine.

In most cases, the drug is unregulated. For instance, in the US, many consumers buy it online and usually, they take it without medical supervision or a doctor's prescription. Since it is taken without a doctor's prescription or supervision, it is likely to bring negative side effects. Some users report favorable experiences, but others have experienced adverse reactions and deleterious side effects.

However, studies have shown the drug to be memory-enhancing and neuroprotective. Since it is peptide-derived compound, it displays a good blood-brain barrier penetration and a high oral bioavailability in human and rats. Studies have also established that it can be used in treating Alzheimer's disease although research in this aspect is still at its infancy. Some people even claim the supplement can help in the growth of brain cells, but this is yet to be proved, at least by experts.

Studies have shown that it is a strong stimulant of two hormones: Brain-Derived Neurotrophic Factor (BDNF) and Nerve Cell Growth (NGF). This is specifically in animals like rats, which is why it could be correlated with the prevention and reduction of neuronal degeneration. The hormones help in keeping neurons healthy and alive. The drug is also thought to strengthen the growth of new synapses and neurons.

The supplement also stimulates receptors and their pathways, such as AMPA. Since it can stimulate brain receptors, it plays a role in the thought and memory processes. Noopept lowers anxiety by interacting with dopamine and nicotinic receptors. It is also thought to have anti-inflammatory and antioxidant properties.


Is There a Need for Noopept? 

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It Improves Brain Health

It Improves Memory Recall and Learning

It Lowers Anxiety and Boosts Mood

Is It Legal?


Noopept Side Effects and Reactions

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Many people who take Noopeptdon't experience any major side effects. The drug has been approved as safe in clinical tests. However, even though it has been deemed safe, that does not mean it can't have undesirable effects. Though researchers have shown that it is effective and has a low toxicity level when taken within the recommended dosage range, it can cause adverse effects in sensitive users.

The common side effects that would result when a person takes the drug in high dosages are:

  • Fatigue
  • Insomnia
  • Nausea
  • Visual changes
  • Temperature changes
  • Tingling sensations
  • Weight changes
  • Restlessness
  • A headache
  • Gastrointestinal Problems

The effects are not limited to the above. Other problems that have been documented include:

  • Sleep

Sleep is an issue associated with the drug's use. Users experience fatigue and grogginess. Some have even reported sleep paralysis after consuming the drug. There are users who blame the drug for causing insomnia.

  • Anxiety

Even though the drug elicits an anti-anxiety effect in many users, some have reported an increase in anxiety. This could be relaxation-induced anxiety. The excess neurophysiologic relaxation after consuming the drug may be uncomfortable and can interfere with the brain performance. If the drug induces brain fog, you may feel anxious, which compromises your brain performance. It is best to discontinue taking the drug if you experience anxiety upon intake.

  • Depression

After taking the drug, depression may occur. Some people report thoughts of death after taking the drug for just three weeks. There is a chance that taking the drug will induce mood shifts. This is because the drug alters acetylcholine, monoamines, and region-specific activity, all of which may contribute to depression. If you have already been diagnosed with depressive disorder, note that the drug could worsen certain depressive symptoms.

  • Memory Impairment

Even though the drug should enhance memory, some users have reported that their memory worsened upon taking the drug. It is unclear whether the worsening of the memory was attributed to improperly calibrated dosage or low choline levels, among other factors. If you notice that you cannot recall information or encode memories after taking the drug, discontinue its usage.

  • Motivational Deficit

Long-term users of the drug have reported a decline in motivation. Initially, users report an increase in motivation, but after several months, the motivational capacity plummets. It is not clear if the deficit is caused by downregulation in certain neurotransmitters.

  • Physical Weakness

Piracetam drugs typically cause weakness. Since Noopept is similar to piracetam, but 1000 times stronger, it has more potential of causing physical weakness. If you're losing strength or feel too weak to complete normal workout routines after taking the drug, it could be the cause.

  • Rapid Thinking

Some people report an acceleration of their thought speed. This is due to an increase in acetylcholine concentrations or neurotransmitter turnover in some brain regions. Even though this is the desired effect, it may also cause thoughts that are random and meaningless, interfering with the ability to focus.  



Noopept is a nootropic and is marketed as a smart drug or cognitive enhancer. It is a dipeptide and is 1000 time stronger than piracetam drugs. It acts as a modulator for the transmission of acetylcholine and improves the functionality of brain receptors. It is unregulated in the US and is mostly sold online. The drug improves brain health, memory recall, and learning. It also lowers anxiety and boosts mood. It is even claimed the supplement can help in the growth of brain cells, but this is yet to be proven by experts.

The common side effects include headaches, fatigue, nausea, irritability, and gastrointestinal issues. It may also lead to visual, weight, and temperature changes, tingling sensations, restlessness, anxiety, depression, memory impairment, motivational deficits, physical weakness, and rapid thinking. Before considering Noopept, consult with your physician.

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