@article {1576, title = {Corticothalamic feedback controls sleep spindle duration in vivo.}, journal = {J Neurosci}, volume = {31}, year = {2011}, month = {2011 Jun 22}, pages = {9124-34}, abstract = {

Spindle oscillations are commonly observed during stage 2 of non-rapid eye movement sleep. During sleep spindles, the cerebral cortex and thalamus interact through feedback connections. Both initiation and termination of spindle oscillations are thought to originate in the thalamus based on thalamic recordings and computational models, although some in vivo results suggest otherwise. Here, we have used computer modeling and in vivo multisite recordings from the cortex and the thalamus in cats to examine the involvement of the cortex in spindle oscillations. We found that although the propagation of spindles depended on synaptic interaction within the thalamus, the initiation and termination of spindle sequences critically involved corticothalamic influences.

}, keywords = {Animals, Biological Clocks, Cats, Cerebral Cortex, Computer Simulation, Feedback, Physiological, Male, Models, Neurological, Neural Pathways, Sleep, Thalamus}, issn = {1529-2401}, doi = {10.1523/JNEUROSCI.0077-11.2011}, author = {Bonjean, Maxime and Baker, Tanya and Lemieux, Maxime and Igor Timofeev and Sejnowski, Terrence and Bazhenov, Maxim} }