Diosmin is a semisynthetic flavonoid molecule derived from citrus d (modified hesperidin). 

Diosmin is used for treating various disorders of blood vessels including hemorrhoids, varicose veins, poor circulation in the legs (venous stasis), and bleeding (hemorrhage) in the eye or gums. It is also used to treat swelling of the arms (lymphedema) following breast cancer surgery, and to protect against liver toxicity. It is often taken in combination with hesperidin.

Diosmin is currently a prescription medication in some European countries, and is sold as a nutritional supplement in the United States.


CAS No.: 520-27-4

EIENCS: 208-289-7

Molecular Formula : C28H32O15

Molecular Weight : 608.545

Specification : EP, BP, USP, 90:10,Micronized

Appearance: Greyish-yellow or light yellow hygroscopic powder





High Assay: ≥95% for EP standard

Impurity Control: Total impurities ≤4.0%

Low Pesticide Residue

Solvents Free

We can also control the quality on customers’ request.


It is the mixture of Diosmin and Hesperidin, which is widely used for pharmaceutical and food supplement.


Benepure has developed new technology to get the mixture directly by reaction process instead of blending.
And the assay can be customized as request.







Raw material harvest time is about June to August.
Benepure would visit the bases and evaluate to make the purchasing plan, and
select properly to guarantee the stability and abundance of the raw material supplying.




The flavonoid hesperidin is a flavanone glycoside (glucoside) comprised of the flavanone (a class of flavonoids) hesperitin and the disaccharide rutinose. Flavonoids are a type of polyphenol, which are antioxidants found in plants and are essential to human health. Besides its antioxidant properties, hesperidin can also be used as an anti-in-flammatory, anti-allergic, hypolipidemic, vasoprotective, and anti-car-cinogenic compound. It seems to reduce the symptoms of allergies and hay fever by inhibiting histamine production in the blood.

Hesperidin, in combination with a flavone glycoside called diosmin, is used for the treatment of venous insufficiency and hemorrhoids.


CAS No.: 520-26-3

EIENCS :208-288-1

Molecular Formula : C28H34O15

Molecular Weight : 610.57

Specification: 90~95% HPLC, 98% UV, Micronized




Hidrosmin, a derivative of Diosmin , is a semisynthetic drug and a member of the flavonoid family. It is used for the treatment of venous diseases.

Compared with Diosmin, Hidrosmin is more effective, which can efficiently treats edema and varicose ulcer. Hidrosmin gains better water solubility, and can be more easily absorbed by human body, less dosage required when people take it.


CAS No.: 115960-14-0

Molecular Formula : C30H36O16

Molecular Weight: 654.6142

Specification: ≥85% HPLC

Appearance: Yellow or yellow-brown hygroscopic powder, odorless




Naringin is a natural chemical compound known as a bioflava-noid found in grapefruit and other citrus fruits, giving it its bitter flavor. Hence, the food industry, uses naringin as a bitter in “tonic” beverages, bitter chocolate, ice cream, and ices.

This bioflavonoid has antioxidant and antifungal properties, as such may help prevent cancer and atherosclerosis (hardening of arteries), as well as a number of other ailments,such as Herpes, Diabetes, Alcoholism, Heart failure, Chronic venous insufficiency, Bruising.

Naringin also works synergistically with other nutrients, increasing the bio-availability (how much nutrient is absorbed by the body) and therefore maximizing the health benefits of these nutrients.


CAS No.: 10236-47-2

EINECS: 233-566-4

Molecular Formula : C27H32O14

Molecular Weight : 580.54

Specification: 98% HPLC

Appearance: Almost white powder




Hesperidin Methylchalcone is a methylate compound of soluble flavanone and soluble dihydrochalcone which can increase the effect of vitamin C with the same function as vitamin P.

What’s more, characters in strong anti-virus and anti-bacteria. It is preventing influenza virus’ breeding with large dosage, inhibiting tyrosinase which causing skin to black.

For the treatment of black spot, freckle such skin disease. It has an effect on remaining normal permeability, boosting resistance, enhancing elastic and toughness of vessels, preventing and curing blooding of capillary or gums.


CAS No.: 24292-52-2

EINECS: 246-128-2

Molecular Formula: C29H36O15

Molecular Weight: 624.59

Specification: 98% UV

Appearance: Yellow powder





It is the 7-O-neohesperidose derivative of hesperetin, which in turn is the 4′-methoxy derivative of eriodictyol. The main use of Neohesperidin is to get Neohesperidin dihydrochalcone which is an intensive sweetener widely used in food and feed industry.。



CAS No.: 13241-33-3

EINECS: 236-216-9

Molecular Formula: C28H34O15

Molecular Weight: 610.56

Specification: 95% HPLC

Appearance: Light white fine powder




Synephrine is the main active ingredient in the citrus auran-tium extract, whichis mainly used in dietary supplements and slimming products.

It can effectively oxidize fat and suppress appetite as the main component of slimming products. Synephrine for the treatment of bronchial asthma and surgery and anesthesia, hypotension, collapse and shock, orthostatic hypotension. Synephrine is also a 21st centurynatural stimulant with no side effects and positive reactions. It is widely used in the health care industries such as medicine, food and beverage. The demand and value of synephrine will increase with the ban on the use of chemicallysynthesized drugs.



CAS No.: 94-07-5

EINECS: 202-300-9

Molecular Formula: C9H13NO2

Molecular Weight: 167.21

Specification: 6%-98% HPLC

Appearance: Brown to white fine powder




Hesperetin is the 4′-methoxy derivative of eriodictyol, a flavanone. Hesperetin’s 7-O-glycoside, is hesperidin. It is obtained from the enzymolyis of hesperidin.

It is mainly coming from the enzymolysis of hesperidin with the functions of invigorating the stomach, eliminating phlegm, preventing cough, expelling rheumatism, treating diuresis, anti-virus, anti-microbial, treating non-return and relieving stomachache, widely used in the food, pharmaceutical and healthcare product industry etc.



CAS No.: 520-33-2

EINECS: 208-290-2

Molecular Formula: C16H14O6

Molecular Weight:302.28

Specification: 90%, 95%, 98% HPLC

Appearance: Light-cream yellow fine powder, melting point: 226-228℃, easily soluble in ethanol, soluble in diluted alkali solution, partly soluble in diethyl ether, slightly soluble in water, chloroform and benzene.




Bioflavonoids are a group of plant pigments that are responsible for the colors of many flowers and fruits. The common citrus bioflavonoidsinclude Apigenin,Diosmin,Diosmetin, Hesperidin, Hesperetin, Naringin, Naringenin, Narirutin, Neohesperidin, Nobiletin, Quercetin, Rutin, Tangeretin.

Citrus bioflavonoids encompass a diverse set of structures, including numerous flavanone and flavone O- and C-glycosides and methoxylat-ed flavones. Each of these groups of compounds exhibits a number of in vitro and in vivo anti-inflammatory and anticancer actions.

These biological properties are consistent with their effects on the microvascular endothelial tissue.
Citrus bioflavonoids and related substances are widely used to treat diseases of the blood vessels and lymph system, including hemorrhoids, chronic venous insufficiency, leg ulcers, easy bruising, nosebleeds, and lymphedema following breast cancer surgery.

Citrus bioflavonoids are thought to work by strengthening the walls of blood vessels.

Citrus bioflavonoids are believed to have antioxidants, anti-viral, anti-inflammatory, and anti-allergy properties. They have been shown to help fight infection, free radical damage, viruses and the common cold.


Specification: 30%-80% HPLC
Appearance: Brownish powder, soluble in dimethyl formamide and formamide at 60℃, slightly soluble in methanol and heat glacial acetic acid, practically insoluble in acetone, benzene and chloroform, freely soluble in dilute alkali and pyridine.