PT - JOURNAL ARTICLE AU - Roth, Bryan L. TI - Neuronal Signal Transduction Pathways: Wasteland or the Promised Land? AID - 10.1126/stke.2000.45.pe1 DP - 2000 Aug 15 TA - Science's STKE PG - pe1--pe1 VI - 2000 IP - 45 4099 - 4100 - SO - Sci. STKE2000 Aug 15; 2000 AB - Review and commentary on Cerebral Signal Transduction: From First to Fourth Messengers, edited by Maarten E. A. Reith. The Humana Press, Totowa, NJ, 2000. 440 pp. $125.00 Proteins used in signal transduction pathways are commonly found in different cell types and organs. However, specific proteins whose expression is highly restricted are also utilized for allowing discrete responsiveness to signals that are otherwise ignored by other cells. How the brain uses common and specific signal proteins for communication within and beyond the cerebrum has been an area of intense study. A new book concentrates on the signaling that occurs in the brain under normal and pathological conditions--memory, apoptosis, neurodegeneration, depression, and drug dependence--and is filled with chapters written by experts in neurobiology and neurophysiology. Bryan Roth reviews the book and discusses in detail several chapters that may lead to promising future research.