Why is LDL oxidized in atherosclerosis

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Title:Antibodies against oxidized LDL as a risk marker for atherosclerosis - A study on 258 patients after diagnostic and interventional coronary angiography at the University Hospital Hamburg-EppendorfOther titles:Autoantibodies against oxidized LDL as a risk factor for atherosclerosisLanguage:GermanAuthor:Kobbe, AyseTags:Antibody; oxidized LDL; Autoantibodies; oxidized; LDL; atherosclerosis; low-density lipoproteinGND keywords:Low-density lipoproteins; Atherosclerosis; oxidationPublication date:2011Day of the oral exam:2011-07-29Summary:
Lipid peroxidation plays a central role in atherogenesis. Antibodies against oxidized LDL (Ox-LDL-Ab) are discussed as a diagnostic marker for atherosclerosis progression. Numerous studies show a connection between Ox-LDL-Ab titers and artherosclerotic diseases and their progression, while other studies could not prove this connection. In this work, the Ox-LDL-Ab titer of 258 patients with coronary artery disease who had a diagnostic or interventional coronary angiography in 1998 was compared with that of 200 healthy blood donors. In addition, lipid parameters were compared between the test subjects and controls. The aim of the present work was to examine whether there is a connection between Ox-LDL-Ab, lipid parameters and the extent of atherosclerosis in order to verify Ox-LDL-Ab as a possible diagnostic marker for atherosclerotic diseases. The lipid parameters associated with atherosclerotic events tended to be found to be elevated in our patient group, although the use of cholesterol-lowering drugs had already potentially influenced pre-existing hyperlipoproteinemia. While other typical risk factors such as an unfavorable apolipoprotein E genotype, smoking, arterial hypertension, diabetes mellitus and a positive family history were found in the patients, no significant difference in the Ox-LDL-Ab titre between the patients and controls could be determined. Hypothetically, these results could be explained by a stronger immune competence of the younger control group and thus the weaker humoral immunity of the older patient group. In conclusion, it can be stated that our results do not allow a connection between Ox-LDL-Ab and the development of atherosclerosis. Further controlled, prospective studies with a sufficient number of cases, standardized Ox-LDL-Ab assays and broad coverage of the previously known risk factors are required in order to define the role of Ox-LDL-Ab in the atherosclerosis process in more detail.
Url:https://ediss.sub.uni-hamburg.de/handle/ediss/4149URN:urn: nbn: de: gbv: 18-52781Document type:dissertationSupervisor:Beisiegel, Ulrike (Prof. Dr. Dr.)Included in the collections:Electronic dissertations and habilitations