

MeSH Review



Disease relevance of Gammaherpesvirinae


High impact information on Gammaherpesvirinae

  • Open reading frame 31 (ORF31) is conserved among the Beta- and Gammaherpesvirinae subfamily, and there is no known mammalian homologue of this protein [4].
  • Phylogenetic trees for both single-gene and concatenated alignments were evaluated thoroughly by maximum-likelihood methods, with each of the three herpesvirus subfamilies (the Alpha-, Beta-, and Gammaherpesvirinae) examined independently [5].
  • These are new characteristics with regard to the general features of gB in the Gammaherpesvirinae subfamily [6].
  • In all cases the three recognised subfamilies (Alpha-, Beta- and Gammaherpesvirinae), and major sublineages in each subfamily, were clearly distinguished, but within sublineages some finer details of branching were incompletely resolved [7].
  • All sequences (gB, DPOL and TERM) showed a close relationship with the corresponding genes of the Gammaherpesvirinae [8].

Chemical compound and disease context of Gammaherpesvirinae


  1. Genetic relations between varicella-zoster virus and Epstein-Barr virus. Davison, A.J., Taylor, P. J. Gen. Virol. (1987) [Pubmed]
  2. The nonessential UL49.5 gene of infectious laryngotracheitis virus encodes an O-glycosylated protein which forms a complex with the non-glycosylated UL10 gene product. Fuchs, W., Mettenleiter, T.C. Virus Res. (2005) [Pubmed]
  3. Relative deficiency in CpG dinucleotides is a widespread but not unique feature of Gammaherpesvirinae genomes. Takács, M., Segesdi, J., Balog, K., Mezei, M., Tóth, G., Mináróvits, J. Acta microbiologica et immunologica Hungarica. (2001) [Pubmed]
  4. Murine gammaherpesvirus 68 open reading frame 31 is required for viral replication. Jia, Q., Wu, T.T., Liao, H.I., Chernishof, V., Sun, R. J. Virol. (2004) [Pubmed]
  5. Toward a comprehensive phylogeny for mammalian and avian herpesviruses. McGeoch, D.J., Dolan, A., Ralph, A.C. J. Virol. (2000) [Pubmed]
  6. Glycoprotein B of bovine herpesvirus 4 is a major component of the virion, unlike that of two other gammaherpesviruses, Epstein-Barr virus and murine gammaherpesvirus 68. Lomonte, P., Filee, P., Lyaku, J.R., Bublot, M., Pastoret, P.P., Thiry, E. J. Virol. (1997) [Pubmed]
  7. Molecular phylogeny and evolutionary timescale for the family of mammalian herpesviruses. McGeoch, D.J., Cook, S., Dolan, A., Jamieson, F.E., Telford, E.A. J. Mol. Biol. (1995) [Pubmed]
  8. Detection and multigenic characterization of a novel gammaherpesvirus in goats. Chmielewicz, B., Goltz, M., Ehlers, B. Virus Res. (2001) [Pubmed]
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