%0 Journal Article %A Kennedy, J %A Kelner, G S %A Kleyensteuber, S %A Schall, T J %A Weiss, M C %A Yssel, H %A Schneider, P V %A Cocks, B G %A Bacon, K B %A Zlotnik, A %T Molecular cloning and functional characterization of human lymphotactin. %D 1995 %J The Journal of Immunology %P 203-209 %V 155 %N 1 %X We describe the isolation of a cDNA that encodes human lymphotactin (Ltn), a new class of lymphocyte-specific chemokine. Human Ltn shows similarity to some members of the C-C chemokine family but has lost the first and third cysteine residues that are characteristic of the C-C and C-X-C chemokines. Ltn is chemotactic for lymphocytes but not for monocytes, a characteristic that makes it unique among chemokines. In addition, calcium flux desensitization studies indicate that Ltn uses a unique receptor. The human Ltn gene maps to a different chromosome than do the C-C and C-X-C chemokine families. Taken together, these characteristics indicate that Ltn is the first example of a new class of human chemokines with preferential effects on lymphocytes. %U https://www.jimmunol.org/content/jimmunol/155/1/203.full.pdf