Phloridzin dihydrate

Phloridzin Dihydrate is a dihydrochalcone produced from apple wood, which reduces blood glucose levels and may be a natural anti-diabetic molecule.

Dietary consumption of Phloridzin has been shown to reduce blood glucose levels. Phloridzin is shown to induce experimental glycosuria by blocking the reabsorption of glucose from the kidney. The anti-diabetic action is through the competitive inhibition of the sodium-dependent blood transporters (SGLT1 and SGLT2) of metabolites such as glucose. Additionally, Phloridzin activates a cascade of enzymes, including tyrosinase, by blocking the activity of protein kinase C. As a result, it is involved in inhibiting the growth of tumor cells and provides increased protection against ultraviolet radiation through the activation of melanogenesis.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
Phloridzin dihydrate, 1g
1g 1-2 weeks
Regular Price:$141.90
On Sale:
Phloridzin dihydrate, 5g
5g 1-2 weeks
Regular Price:$567.60
On Sale:

Product Type: Small Molecule
Chemical Formula: C21H24O10, 2H2O
CAS number: 7061-54-3
Molecular Weight: 472.44
Format: White crystalline solid
Purity: >99 % determined by HPLC
Solubility: Soluble in boiling water, methanol, ethanol, acetone, and ethyl acetate.
Stability: Stable when stored at 4C away from oxygen and direct sunlight
Storage: 4C, avoid exposure to heat and direct sunlight
Shipped: Ambient temperature


Phloridzin dihydrate HPLC Chromatogram.

Purification Notes: Extracted from apple wood using segmentation chromatography.

  4. The Merck Index (2001). Thirteenth Edition. p. 7414.
