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Neurocognitive Disorders (NCD)

Oxidative stress is implicated in several disorders of the brain including neurodegenerative disorders resulting in cognitive impairment.

These may be due to Alzheimer’s Disease, vascular disorders, Parkinson’s disease, HIV infection, TBI and CTE, among others.

However, there are many cases of NCD where a clear disease-related etiology cannot be determined, and they are primarily due to environmental and other unspecified causes.

“Brain fog” is associated with poor mental function, especially regarding concepts, words, memories, and is characterized by confusion, forgetfulness, difficulty in concentration, and maintenance of focus.

Sleep patterns are often disturbed and defective REM (dream) sleep may result in serious depressive disorders.

Extreme somatic and psychological fatigue, severe stress, and sleep deprivation are potential precipitating factors.

In the military, psychological fitness is defined as the integration and optimization of mental, emotional, and behavioral abilities and capacities to optimize performance and strengthen the resilience of warfighters.

Appearance of NCD symptoms severely impacts the ability of military personnel to function properly.

BBI is investigating the usefulness of NACA in NCD associated with military conditions.