Research Paper Volume 12, Issue 5 pp 4489—4505

Methionine abrogates the renoprotective effect of a low-protein diet against diabetic kidney disease in obese rats with type 2 diabetes

Figure 2. Biological parameters of rats. Blood glucose levels under ad libitum feeding during the 20-week experimental period (A), mean blood glucose levels under ad libitum feeding over the entire study (B), HbA1c levels (C), mean food intake over the entire study (D), fasting T-CHO (E), TG (F), postprandial plasma FGF21 levels (G), urinary albumin/Cr ratio (H), urinary L-FABP/Cr ratio (I) and urinary 8-OHdG/Cr ratio (J), at the end of the study (n=7). The data shown are the means ± SD. #p<0.05, ##p<0.01 vs. diabetes, ††p<0.01 vs. diabetes + LPD, *p<0.05, **p<0.01, ***p<0.001 vs. the indicated groups. ns: not significant. White circles: control, black circles: diabetes, white triangles: diabetes + LPD, black triangles: diabetes + LPD + Met. T-CHO: total cholesterol, TG: triglyceride, FGF21: fibroblast growth factor 21, Cr: creatinine, L-FABP: liver-type fatty acid binding protein, 8-OHdG: 8-hydroxy-2'- deoxyguanosine.