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Effects of inhaled fluticasone propionate on CTLA‐4‐positive CD4+CD25+ cells in induced sputum in mild asthmatics

Background and objective:  Cytotoxic T‐lymphocyte antigen 4 (CTLA‐4) signalling of regulatory T cells regulates mucosal lymphocyte tolerance and differentiation, and may therefore have a beneficial effect in allergic diseases such as asthma. The aim of this study was to evaluate the effects of fluticasone propionate (FP) on CD4+CD25+ T cell co‐expression of CTLA‐4 in the sputum of mild asthmatic subjects.