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A nigro‐vagal pathway controls colonic motility and may be impaired in a model of environmental Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor deficits caused by the loss of substantia nigra pars compacta (SNpc) dopaminergic neurons. It is well known that the majority of PD patients experience gastrointestinal (GI) dysfunctions such as gastroparesis, impaired swallowing and severe constipation. Upper GI tract functions are modulated by vagal reflexes, the central neurocircuit of which are located in the dorsal vagal complex (DVC, i.e. dorsal motor nucleus of the vagus (DMV), nucleus tractus solitarius and area postrema). We discovered a monosynaptic nigro‐vagal pathway recently that modulates gastric tone and motility and is impaired in an environmental PD model induced by oral administration of subthreshold doses of paraquat (P) and lectin (L). It is not known, however, whether this pathway also modulates colonic motility and whether the P+L model of PD decreases intestinal transit.