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Uterine Natural Killer Cells Do Not Require Interleukin‐2 for Their Differentiation or Maturation

PROBLEM: Natural Killer lymphocytes (NK cells) from the pregnant uterus and from other tissues in pregnant and nonpregnant mammals can be stimulated by interleukin‐2 (IL‐2) during culture to become Lymphokine Activated Killer (LAK) cells. The susceptibility of cultured trophoblast cells to lysis by LAK cells raises the enigma of why uterine (u) NK cells that are characterized by morphology and by surface phenotyping as “activated,” and thus potentially damaging to the placenta, become localized to implantation sites during normal rodent gestation.