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Inactivation and reactivation of 20-hydroxyecdysone during pupal-adult development of the fleshfly, Sarcophaga peregrina.

The inactivation process of ecdysteroids during pupal-adult development of the fleshfly, Sarcophaga peregrina, was analyzed by following injected 3H-20-hydroxyecdysone, 20-Hydoxyecdysone was rapidly metabolized and converted mostly into three groups of metabolites, one of which was closely related to 20-hydroxyecdysone in its chemical nature and the other two were polar conjugates of 20-hydroxyecdysone (OA and OB). The first group of metabolites decreased through the first day after injection of 20-hydroxyecdysone, and began to increase thereafter. Those of conjugates OA and OB increased through the first day after the injection and then began to decrease. The conjugate OA introduced into phraate pupae changes to less polar substances, liberating 20-hydroxyecdysone at the beginning of adult development. Since the conjugates OA and OB did not exhibit any appreciable moulting hormone activity, we consider that some part of 20-hydroxyecdysone synthesized during larval-pupal development is stored as conjugate forms until the beginning of adult development, and that the conjugate OA is converted to 20-hydroxyecdysone for adult development.