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Analysis of morphologic patterns of fine‐needle aspiration of the breast to reduce false‐negative results in breast cytology

The identification of specific morphologic diagnostic criteria is of paramount importance to optimize the accuracy of fine‐needle aspiration cytology (FNAC) and to reduce the rate of false‐negative results. In the current study, the authors reviewed a consecutive series of false‐negative findings observed in the study center to define the presence and degree of cytologic abnormalities. False‐negative cases were randomly mixed with true‐negative cases and were reviewed by a panel of expert readers in a blinded fashion. The main objective of the current study was to identify a morphologic pattern that may permit the reduction of false‐negative findings while maintaining the specificity of FNAC.