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CALCITONIN‐PRODUCING INSULINOMA: An Immunohistochemical and Electron Microscopic Study

A pancreatic endocrine tumor measuring 1.5×1.0×1.0 cm in a 67‐year‐old man with recurrent hypoglycemic attacks was examined by immunohistochemistry and electron microscopy. The tumor cells were relatively uniform, and almost all of them were immunoreactive to Insulin. A few calcitoninpositive cells could be identified scattering in tumor cell strands, and the content of calcitonin in the tumor was 85 ng/g wet tissue. Coexistence of insulin and calcitonin in tumor cells was demonstrated by using adjacent semithin sections of the Epon‐embedded material. Electron microscopically, the tumor consisted of a single type of cells with secretory granules identical to B‐cell granules in the normal counterpart.