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Opioid-induced hyperalgesia method is a clinically relevant issue.

The manuscript by Mercadante et al. (1) on opioid-induced 
hyperalgesia after rapid titration with intravenous morphine: 
switching and re-titration to intravenous methadone is not only 
interesting, but also provides clinically relevant information. As 
evidenced by multiple publications, opioid-induced hyperalgesia 
is no longer an extraneous research phenomenon. Its clinical 
relevance and importance are increasingly recognized (2,3).