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Metformin revisited: re‐evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents

Background:  The usefulness of metformin as an oral antidiabetic agent is widely accepted. However, several other classes of oral antidiabetic agents have been recently introduced, raising the need to evaluate the role of metformin as initial therapy and in combination with these newer drugs for treatment of type 2 diabetes mellitus (DM).