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ABO alleles are linked with haplotypes of an erythroid cell‐specific regulatory element in intron 1 with a few exceptions attributable to genetic recombination

Recent investigation of transcriptional regulation of the ABO genes has identified a candidate erythroid cell‐specific regulatory element, named the +5·8‐kb site, in the first intron of ABO. Six haplotypes of the site have been reported previously. The present genetic population study demonstrated that each haplotype was mostly linked with specific ABO alleles with a few exceptions, possibly as a result of hybrid formation between common ABO alleles. Thus, investigation of these haplotypes could provide a clue to further elucidation of ABO alleles.