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Focused ultrasonic transducer for localized sonodynamic therapy

The aim of this study is to develop the focused ultrasonic transducers using a concave-shaped PZT for localized sonodynamic therapy in the human body. The concave-shaped PZT was fabricated from a bulk PZT using a high-speed micro-milling machine, and then repolarized for the optimized polarization direction. The measurement result of the acoustic field using a PVDF hydrophone indicated that the ultrasound emitted from the focused ultrasonic transducer was successfully focused in three-dimensions. At the focal point, the measured peak intensity would be sufficient for sonodynamic therapy.