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[Effects of adrenoreceptor agonists and cyclic nucleotides on membrane potential of isolated endothelial cells of the rabbit aorta].

The influence of adrenoceptor agonists and changes in the intracellular cyclic nucleotide concentration on the membrane potential of an isolated endothelial cell layer from rabbit aorta has been investigated. The alpha 1-adrenoceptor agonist phenylephrine evoked deep depolarization of the endothelium of an intact aorta, but had a little effect on the membrane potential of the isolated endothelium. The nonselective adrenoceptor agonist noradrenaline, the beta-adrenoceptor agonist isoproterenol and the inhibitor of phosphodiesterases IBMX all strongly depolarized the isolated endothelium. These data suggest that the rise in cyclic nucleotide concentration depolarizes endothelial cells, and this fact may account for the noradrenaline-induced depolarization of the endothelium through beta-adrenoceptors.