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Coffee drinking and risk of coronary heart disease. Cholesterol concentration may have been within natural fluctuations.

Editor–Rob Urgert and colleagues compared the effects of filtered and cafetière coffee on blood lipid concentrations and found that "After 24 weeks low density lipoprotein cholesterol concentrations were raised by 0.26 (SE 0.11) mmol/l, or 9% over baseline values relative to filtered coffee (P=0.03)." I am sceptical about the biological importance of differences with P values of this order; nor can we rule out the possibility that, had the experiment continued for longer, the plasma cholesterol concentration in the cafetière group might have returned to around the baseline value.