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Prevalence of Headache in Patients With Mitochondrial Disease: A Cross‐Sectional Study

Mitochondrial diseases are a heterogeneous group of diseases with different phenotypes and genotypes. Headache and, particularly migraine, seems to occur often in patients with MELAS and in patients with CPEO phenotypes. The International Classification of Headache Disorders (ICHD‐3 beta) has classified headache as a secondary entity only in MELAS patients. Other headache phenotypes in mitochondrial diseases are not considered in ICHD‐3beta. In this study, we analyzed headache phenomenology in a large group of patients with mitochondrial disorders.