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From the mouth to gut: A microbial journey!

The oral microbiome invades almost the whole of the body, resulting in “n” number of systemic diseases. The gut is no exception in falling short to them. Many studies both in the four legged animals and their two legged successors (presumed to be the humans) have concluded that the oral microbiome can translocate to the gut and change its microbiota and eventually the immune defense. This ectopic displacement of oral microbiome specifically occurs in severe systemic diseases. Most commonly it is seen having its rage in patients with chronic periodontitis. Dysbiosis in the subgingival microbiota and immune defense, sometimes dysregulation in the gut, turns out to be the threat posed by the oral microbes. Among the other tiny troublemakers, Porphyromonas gingivalis remains the most serious. A dysbiotic gut microbiota may further cause diseases elsewhere in the body. The fact that chronic periodontitis may affect the gut microbiota suggests that the future would foresee a coordinated approach to the treatment of periodontitis and gastrointestinal diseases. Although this specific area of investigation is still a bud, it may portray different pathways for the oral microbiome to cause systemic diseases thence deserving a detailed probe furthermore.