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Micropatterned substrates: Tools for studying cell motility and aiding rational drug design

We have developed a novel class of cell biology tools for the quantification of cytoskeletal organization and dynamics in populations of cancerous cells with low variability. Anisotropic Solid Microetching (ASoMiC) was used to constrain cells onto transparent microislands and subsequently imaged. This methodology creates a unique platform for studying cell motility and identifying therapeutic targets.