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The evaluation of the maculopathy using dynamic contrast-enhanced MRI in patients with proliferative diabetic retinopathy.

BACKGROUND
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) technique could not only quantify blood-retinal barrier (BRB) breakdown leading to macular edema associated with diabetes but also provide a two-dimensional imaging method that is not interfered by refracting media.


OBJECTIVE
The current study was aimed to evaluate the macular change in patients with diabetic retinopathy using the DCE-MRI technique.


METHODS
Twenty patients with diabetic retinopathy (DR) and 20 normal controls (NC) were included. The fast spoiled gradient-echo sequence was used to perform dynamic contrast T1WI enhancement on a 3.0T MR system. The assessments of the macular region, optic papilla, and nasal retina were performed with quantitative DCE-MRI evaluation using Omni-Kinetics software.


RESULTS
The maximal concentration, the area under the concentration-time curve (AUCconcentration-time), and maximal slope of macular region were significantly higher in DR [0.270(0.03,1.20)mmol/100ml, 2.71(0.04,9.91) mmol*min, and 0.38(0.06,3.18) mmol/min, respectively] than that [0.169(0.03,0.72) mmol/、1.25(0.13,10.41) mmol*min, and 0.245(0.06,1.34) mmol/min] in NC (U value = 515.00 and P value = 0.080, U value = 433.00 and P value = 0.000, and U value = 563.00 and P value = 0.023, respectively). The receiver operating characteristic curve (ROC) analysis demonstrated that the area under AUCconcentration-time was 0.729±0.058 with the cut-off value of 1.479 mmol*min (sensitivity 80.00% and specificity 62.50%) for macular region.


CONCLUSION
The quantitative DCE-MRI technique could be used to evaluate the maculopathy associated with diabetic retinopathy.