{'fraction_non_alphanumeric': 0.022154606827041932, 'fraction_numerical': 0.008082152705144053, 'mean_word_length': 5.231042654028436, 'pattern_counts': {'":': 0, '<': 1, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 1, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Large Borderline Ovarian Tumor: A Case Report

Surface epithelial-stromal tumors are believed to originate from the surface epithelium of the ovary. They are classified as benign if they lack exuberant cellular proliferation and invasive behavior; as borderline (also known as atypically proliferating or of low malignant potential) if there is exuberant cellular proliferation but no invasive behavior; and as malignant if there is invasive behavior. Surface epithelial-stromal tumors account for approximately 60% of all ovarian tumors and approximately 90% of malignant ovarian tumors.


Introduction
Most tumors of the ovary can be placed into one of three major categories; surface epithelial-stromal tumors, sex cord-stromal tumors, and germ cell tumors according to the anatomic structures from which the tumors presumably originate.
Surface epithelial-stromal tumors are believed to originate from the surface epithelium of the ovary. They are classified as benign if they lack exuberant cellular proliferation and invasive behavior; as borderline (also known as atypically proliferating or of low malignant potential) if there is exuberant cellular proliferation but no invasive behavior; and as malignant if there is invasive behavior. Surface epithelial-stromal tumors account for approximately 60% of all ovarian tumors and approximately 90% of malignant ovarian tumors.
Mucinous tumors are epithelial ovarian tumors formed by cells that resemble either those of the endocervical epithelium (endocervical or mullerian type) or, more frequently, those of the intestinal epithelium (intestinal type). Benign mucinous tumors are multiloculated cysts that are filled with opaque, thick, mucoid material. They account for up to one-fourth of all benign ovarian neoplasms and 75-85% of all mucinous ovarian tumors. Benign mucinous tumors most frequently occur between the third and fifth decades of life and are rarely bilateral [1]. Surgical removal is curative. The differential diagnosis is broad, including pancreatic cystic lesions, mesenteric cyst, lymphocele, cystic lymphangioma, cystic mesothelioma, teratoma, cystic hydatidosis, intraperitoneal pseudomyxoma peritonei and peritoneal carcinomatosis [2].
The concept of borderline epithelial tumors of the ovary has faced controversy since their descovery in 1898 by Hermann Johannes Pfannenstiel, who illustrated and described papillary ovarian cystadenomas with clinical features that stand on the border of malignancy [3]. Borderline tumors have been thought to possibly represent an intermediate stage in the stepwise progression to carcinoma. In the FIGO classification, the common primary epithelial tumors were subdivided into three groups: benign cystadenoma; cystadenoma with proliferating activity of the epithelial cells and nuclear abnormalities, but with no infiltrative destructive growth (low potential malignancy); and, cystadenocarcinoma [4]. According to the WHO definition, a borderline epithelial tumor lacks obvious invasion of the stroma and has mitotic activity and nuclear abnormalities intermediate between clearly benign and unquestionably malignant tumors of a similar cell [5].
In 1988, two basic types of borderline mucinous tumors were delineated: the intestinal type and the endocervical-like (Mullerian) type. The endocervical-like type is clinically and pathologically closely related to serous borderline tumors with which it is often mixed (also known as seromucinous borderline tumor and Mullerian borderline mucinous tumor). It accounts for only 5-14% of borderline mucinous tumors [6] and has little in common with intestinal-type mucinous tumors. The pure and mixed endocervical-like borderline mucinous tumors have a high association with endometriosis which is the site of origin of the tumors in some instances [7].
This report presents the short evolution (3-4 months) of a large mucinous cystadenoma in a 59 year old Caucasian woman.

Materials and Methods
A 59 year old Caucasian woman presented to the Clinical Hospital "Dr. Ioan Cantacuzino" in Bucharest with a progressively enlarged abdomen without manifesting any other clinical signs. The patient stated that she had first noticed her abdomen increasing in size over 3 months ago but she chose to ignore it as she did not feel any pain or discomfort. The physician's first presumable diagnosis was that the woman could be pregnant.
The patient's history revealed that she had hydrocephalus in 1998 and had had a ventriculoperitoneal shunt inserted. During her lifetime she has given birth to 5 babies and has had 3 abortions. She entered menopause when she was 48 years old. She is a moderate smoker and occasionally drinks alcohol.

Results
Physical examination revealed an enlarged abdomen with a palpable fixed formation along the xifo-pubian line. The formation did not provoke any pain when palpated and the percussion revealed dull sounds. The blood work of the patient came back normal having only a  (Figure 1).
The ultrasonography showed a large cystic formation (19/19/31 cm) with a well-defined wall and a hypoechoic image inside of approximately 12.6 cm in diameter which contained multiple cysts. The formation was a space occupying process which had pushed the entire colon and the intestinal loops; it had moderate vascular drawings and was adherent to the abdominal aorta and the inferior vena cava. The image was suggestive for a lymphangioma.
The CT revealed a large cystic formation occupying most of the abdomen (Figure 2). It had a good vascular supply which seemed to originate from the vascular pedicle of the left ovary. The tumor was pushing on the urinary bladder and the uterus; the kidneys had a grade 1 hydronephrosis. All the intestinal loops and the supramezocolic organs were pushed against the diaphragm.
Surgical intervention followed. A large xifo-pubian incision was made to allow access to the entire tumor. Left salpingo-oophorectomy was performed. The uterus and right adnexa looked healthy and there was no apparent lymph node infiltration. The cyst, which was adherent to the left ovary was removed (it measured in diameter 28/22 centimeters) and 4L of liquid were drained from it. Intraoperative histology using frozen section is useful; however the technique was unavailable at the time [8].
Post-operative recovery was uneventful. The patient was discharged after 5 days of close observation and told to come back every 6 months during a period of 2 years for follow-up [9,10] (Figures 3 and 4).
The histological examination revealed a multilocular mucinous cystadenoma with borderline areas and necrosis. The left salpinx had thickened mucus creases. Towards the internal layer of the cyst there are papillary proliferations and ramifications. You can also observe unistratified and pluristratified layers of cylindrical and cubic cells of different sizes along with areas that appear to be squamous metaplasia. In our samples we can see intensely basophilic nuclei and citoplasm with   various degrees of acidophilia. This suggests a highly increased rate of division which is specific for borderline tumors ( Figure 5).
The epithelium of the cyst is made out of one layer of cubic cells mixed with cilindrical cells. The cells have a basal nucleus. The stroma is rich in fibroblasts with frequent capillaries. Col H.E. x 10.

Discussion
Mucinous tumors of the ovary demonstrate marked morphological diversity, both within the group as a whole and in individual tumors. A major change that has occurred relatively recently is the subdivision of mucinous tumors into those of intestinal and Müllerian types. In contrast to intestinal-type tumors, Müllerian borderline tumors are typically lined by endocervical-like mucinous cells and often performed either radical or conservative depending on the histological type of the tumor [13,14].

Conclusion
This patient is presented as a special case because of the rapid onset and evolution of the tumor as well as its impressive size and evolution which are characteristic for borderline tumors of the ovary.
In our patient, conservative surgery was chosen because of the macroscopic and microscopic (extemporaneus histopathology) aspect of the tumor. Left salpingo-oophorectomy was performed because the mass was adherent to the left ovary and the left fallopian tube was unhealthy. The uterus and right adnexa were left intact as there was no apparent infiltration or any other signs of metastasis. Conservative surgery as ovarian cystectomy and salpingo-oophorectomy is adequate for benign lesions. Postoperatory monitoring of patients plays a critical role in case of any possible relapses, especially consequent malignant evolutions. The follow-up is done by performing ultrasound and contrast CT every 6 months for a minimum of two years post operatory.  have distinctive polygonal cells with eosinophilic cytoplasm. They are characterized by large papillae similar to those seen in serous borderline tumors and occasionally in endometrioid borderline tumors. Mulleriantype tumors are also frequently associated with pelvic endometriosis, unlike intestinal-type tumors. A morphological continuum exists from mucinous cystadenoma to mucinous carcinoma, and epithelium that varies from benign to borderline to frankly malignant is frequently found within a single tumor. Because of this continuum, drawing the line between these three major categories of neoplasia can be problematic [11]. A tumor composed predominantly of cystadenoma with a minor component of borderline tumor (<10%) should be primarily diagnosed as a mucinous cystadenoma. Upon gross pathologic examination, borderline mucinous tumors are similar to benign mucinous tumors but may have solid regions and exhibit papillae projecting into the cyst chambers [12].
Ovarian tumors are seen frequently in medical practice but giant tumors that have a rapid growth and present with no symptoms are rare. Early detection is the key to improving the outcome of the patient but it is difficult to discover something that the patient does not complain about. Usual symptoms that can be seen in such patients include: pressure or pain in the abdomen or legs, indigestion, diarrhea, constipation, gas, polyuria, shortness of breath, vaginal bleeding. Screening is very important and should be done regularly; however, in this case it was unhelpful because of the rapid onset and development of the tumor. Surgery with the intent of excising the lesion is the elected method of treatment and it can be