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METHODOLOGICAL INVESTIGATIONS ON THE IN VITRO UPTAKE OF 5‐HYDROXYTRYPTAMIN BY HUMAN BLOOD PLATELETS

Blood platelets and monoamine-containing nerve endings of the brain share anatomical and functional properties, particularly with regard to active uptake, storage, and release of 5-hydroxytryptamin (serotonin). Thus experimentally induced changes in the serotonin metabolism of blood platelets may reflect changes occurring intraneuronally (Page ( 1968), Paasonen ( 1968), Murphy ( 1969) ). In a series of investigations on the effect of drugs used in manic-depressive illness, e. g. lithium, on brain serotonin metabolism, we were therefore interested in examining also the effect of these drugs upon blood platelets in vit 7 0 . However, with this particular aim of the study, it was felt that some of the usually applied analytical procedures for examination of blood platelets might lead to erroneous conclusions. We were, in this respect, particularly concerned about the use of Ca++and Mg++ -removing anticoagulants. The present study was undertaken to establish the significance, for this particular type of investigation, of some analytical details, i. e. type of incubation medium, incubation period, concentration of serotonin and pH of the incubation medium, and the use of anticoagulants.