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Natural Products: Anti‐inflammatory Activity in Rats and Mice of Phenolic Acids Isolated from Scrophularia frutescens

Different species of the Scrophularia genus (Scrophulariaceae) have been reported to have bacteriostatic and anti‐inflammatory properties. In previous studies the anti‐inflammatory and antibacterial activity of different extracts from Scrophularia frutescens were investigated and p‐coumaric, caffeic, ferulic gentisic, protocatechuic, syringic and isovanillic acids were isolated and identified. In this work the anti‐inflammatory activity of these compounds, administered orally, has been studied against carrageenan‐induced rat paw oedema and, administered topically, against tetradecanoylphorbol acetate (TPA)‐induced mouse ear oedema. The compounds' myeloperoxidase activity in inflamed ear was also investigated.