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Systematic and scoping reviews to assess biological parameters.

INTRODUCTION
The evidence synthesis approach compiling biological/laboratory data is effective in advancing health-related knowledge. However, this approach is still underused in the oral health field.


METHODS
This Commentary discusses the opportunities and challenges of systematic and scoping reviews of laboratory data in dentistry. Special focus is put on the potential of these reviews to elucidate etiological and treatment concepts of oral diseases, such as periodontitis and periimplantitis.


RESULTS
The following difficulties associated with such studies are discussed: (i) selection of ideal study design, (ii) assessment of "risk of bias" and definition of "certainty of evidence", (iii) evidence assembly and summary, and (iv) paper review process.


DISCUSSION
Despite those challenges, high-quality reviews integrating laboratory data may generate relevant scientific information and help identify new avenues for future investigations. Experts in different oral health topics should build a process capable of helping researchers assemble and interpret these types of data.