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Optic Atrophy in Two Brothers

July 25, 1935: On July 3 the right eye was removed and a section was examined by Mr. F. Law, who has kindly supplied the following report:Macroscopic appearance: An opaque membrane stretches across in the position of the iris, of which the root is seen. The appearance is that of total detachment of the retina with cyst formation. Microscopic appearance: The cornea is degenerate, thinned and infiltrated. The anterior chamber is irregular in depth and contains exudate. Dislocated degenerate lens remnants are seen in which bone formation has occurred. Organized fibrous connective tissue stretches across from the root of the iris on either side: the ciliary body is unrecognizable as such, and no ciliary processes are found. The retina is totally detached, degenerate, and drawn forwards in the position close behind this membrane: hemorrhage and intraretinal cysts are present. The vitreous chamber is occupied by a hyaline exudate. The choroid is atrophic and sclerosed. There is pathological excavation of the optic disc and the optic nerve is hypercellular and atrophic.