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Association of cognitive performance and psychological traits with diffusion‐weighted tract metrics in older adults with subjective cognitive decline and mild cognitive impairment

Subjective Cognitive Decline (SCD) may represent the earliest clinical manifestation of Alzheimer’s disease (AD) (Jessen et al. 2014). In individuals with SCD and mild cognitive impairment (MCI), changes in white matter (WM) microstructure have been shown using diffusion weighted (DW) imaging (Brueggen et al. 2019). However, it is unknown to which extent these alterations are associated with cognitive and psychological deficits. Thus, this study aims to investigate the relationship between WM tract metrics and cognitive performance as well as psychological traits in pre‐dementia stages of AD.