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Correspondence: radiosensitivity of surviving cells in tumours pretreated with continuous irradiation.

In his comment on our paper entitled “Effects of continuous irradiation at low dose-rates on a rat rhabdomyosarcoma” (Kal and Barendsen, 1972), Dr. Liversage implies that the greater response of surviving cells in tumours pretreated at low dose rates as compared with cells in untreated tumours to an acute dose of 800 rads, may be entirely due to accumulation of sublethal damage during the protracted pretreatment (Liversage, 1973). From our experimental data it can be deduced, however, that at least three factors can play a part in the response of these cells, namely a rapid reoxygenation, changes in cell age distribution, and repair of sublethal damage.