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Endothelial function measured using flow‐mediated dilation in polycystic ovary syndrome: a meta‐analysis of the observational studies

Women with polycystic ovary syndrome (PCOS) demonstrate an increased prevalence of cardiovascular disease (CVD) risk factors. Previous researchers have compared flow‐mediated dilation (FMD), an early marker of CVD, in women with and without PCOS. Evidence for a PCOS‐mediated reduction in FMD remains equivocal, potentially because of study differences in cohort‐matching and measurement approaches. The aims of this systematic review and meta‐analysis were to examine to what extent FMD is impaired in PCOS and to explore the influence of potential moderators of FMD reduction, such as age and BMI.