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[An evaluation of the long-term effect of clustered immunotherapy in house-dust-mite-sensitive adult bronchial asthma].

The optimal treatment period for specific immunotherapy in atopic asthma remains to be established. The present study was undertaken to evaluate the efficacy and the optimal treatment period of immunotherapy in adult asthma patients. Eight house-dust-mite-sensitive asthmatics were initiated by clustered immunotherapy (C-IT) using house-dust (HD) antigen followed by maintenance treatment with 10-fold dilution of HD. The increase in morning peak expiratory flow rate reached a plateau at 16 weeks following C-IT. On the other hand, the maximal improvement in clinical scores was observed at a year following C-IT. Thus, it would be reasonable to determine the clinical response of immunotherapy at a year following maintenance treatment.