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Classification and management of brittle asthma.

The term ‘brittle asthma’ was first used by Turner-Warwick (1977) to describe patients with asthma whose peak expiratory flow (PEF) varied ‘chaotically’; a pattern which could lead to death from an acute severe attack (Bateman and Clarke, 1979; Westerman et al, 1979). Morbidity from brittle asthma is considerable, and this review aims to identify possible causes and management strategies for this group of patients.