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Programmable shape-shifting micelles.

Nanoscale particles that undergo reversible and defined changes in morphology in response to stimuli are expected to have broad utility in a range of applications, including targeted drug delivery, detection strategies, soft templates, and self-healing materials. To date, programmable materials with these properties have not been reported, despite the many elegant examples of stimuli-responsive soft nanoparticles and micelles.[1–11] Inspired by the utility of DNA as an informational molecule in nanotechnology,[12–20] we report herein DNA-encoded polymeric materials that are capable of in situ controlled, selective, reversible, and user-defined shifts in morphology. The design is based on polymeric micelles formed from a novel set of amphiphilic DNA-brush copolymers (Figure 1).[16,21] By utilizing the sequence-selective recognition properties of DNA,[22] and its performance as a substrate for selective enzymatic cleavage,[23,24] information stored in the micelle shell may be read and manipulated in several modes, causing dramatic changes in morphology and particle size.