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Visually evoked changes of blood flow velocity and pulsatility index in the posterior cerebral arteries: a transcranial Doppler study.

OBJECTIVE
Transcranial Doppler sonography (TCD) can detect visual evoked blood flow responses non-invasively and continuously with high temporal resolution. While the mean flow velocity response to visual stimuli is well documented, the response of the pulsatile characteristics of the waveform is less well known.


METHOD
We examined the changes of blood flow velocity and pulsatility index (PI) in the posterior cerebral artery (PCA) in 50 healthy volunteers. TCD responses were measured in response to metabolic activation of the visual cortex by visual stimulation.


RESULTS
A specific, stimulus-related increase of the mean flow velocity (MFV) in the PCA was found. The intensity of the blood flow response was significantly influenced by the complexity of the stimulus. During complex visual stimulation we found a mean flow velocity (MFV) increase of 29.4 % from the baseline in the subjects. However, a stimulus-related decrease was observed in the pulsatility index (PI); although the mean PI with closed eyes during baseline measurement was 1.18 (SD 0.27), on average, it fell significantly to 0.95 (SD 0.23) with the alternating chessboard and 0.82 (SD 0.22) during the complex stimulus condition. The relative decrement of the pulsatility index with increasing complexity of the visual stimulus is highly significant, with values of -19.5 % and -30.5 % compared to the baseline.


CONCLUSION
These findings demonstrate the inverse correlation between MFV response and pulsatility index in the PCA. We assume that this decrease of the PI in the PCA may reflect the reduced regional vascular resistance in the visual cortex during visual stimulation.