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Expression of Cre recombinase in mouse oocytes: A means to study maternal effect genes

., 1998). Thesematernally derived transcripts are responsible for thecompletion of meiosis, initiation of mitosis, activation ofthe embryonic genome, and completion of the transfor-mation of the highly differentiated oocyte into a totipo-tent embryonic cell. To study the effect of speciﬁc ma-ternal transcripts on these processes, we have sought toestablish a Cre-