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Absence of magnesium sparing effect of a single dose of triamterene in combination with frusemide in healthy male adults.

In a study of cross-over randomized design in 12 healthy volunteers we compared the effect on magnesium excretion after administration of single oral doses of frusemide 40 mg (F) and of frusemide 40 mg in combination with a single dose of triamterene 50 mg (F+T). F as well as F+T induced significant increases in volume, sodium and magnesium mean 24 h output as compared with 24 h renal excretion without medication. Addition of triamterene to frusemide significantly reduced the 24 h potassium excretion, but did not attenuate the excretion of magnesium. The time to reach the maximum magnesium excretion rate after F as well as after F+T administration was similar to that of the sodium excretion rate. We conclude that triamterene does not inhibit the magnesiuric effects of frusemide in healthy male adults.