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Adjunctive cholestyramine therapy for thyrotoxicosis *

OBJECTIVE Initial therapy of thyrotoxicosis usually includes beta‐blockade for symptom relief and thionamides to block new thyroid hormone synthesis. In view of the increased enterohepatic circulation of thyroxine (T4) and triiodothyronine (T3) in thyrotoxicosis, we proposed that cholestyramine, an anion exchange resin which binds iodothyronines, when used adjunctively with thionamides and a beta‐blocker, would lower serum iodothyronine levels faster than would standard therapy alone.