{'fraction_non_alphanumeric': 0.017584994138335287, 'fraction_numerical': 0.004689331770222743, 'mean_word_length': 5.832, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
N‐Acetylcysteine Attenuates Aldosterone induced Vasoconstriction in Individuals with Type 2 Diabetes

Individuals with type 2 diabetes (T2D) have a high risk of developing cardiovascular disease. Chronic elevation of plasma aldosterone could contribute to endothelial dysfunction within this population by ROS dependent mechanisms. The antioxidant N‐acetylcysteine (NAC) is known for its free radical scavenging properties and NAC may potentiate the activity of nitric oxide (NO) directly by increasing NO‐bioavailability. A shift in the balance between vasoconstrictor and vasodilator responses to aldosterone could be involved in the detrimental actions of aldosterone, and NAC could revoke this effect. The purpose of this study was to investigate if infusion of NAC would improve the vascular response to infused aldosterone in individuals with T2D.