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Acute Hypotensive Reaction to Etoposide with Successful Rechallenge: Case Report and Review of the Literature

Hypotension, bronchospasm, and facial flushing associated with an intravenous infusion of etoposide occurred in a 38-year-old man with advanced testicular cancer. The reaction began within three minutes after the initiation of the infusion and was reversed with intravenous fluids and diphenhydramine. He was successfully retreated with four additional doses of etoposide after pretreatment with diphenhydramine and dexamethasone. The literature concerning similar anaphylactoid reactions to intravenous etoposide is reviewed.