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Parallel detection of fundamental and 6th harmonic signals using an ICR cell with dipole and 6th harmonic detectors.

Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) is a powerful instrument for high-resolution analysis of biomolecules. However, relatively long signal acquisition periods are needed to achieve mass spectra with high resolution. The use of multiple detector electrodes for detection of harmonic frequencies has been introduced as one approach to increase scan rate for a given resolving power, or to obtain increased resolving power for a given detection period. The achieved resolving power and scan rate increase linearly with the order of detected harmonic signals. In recent years, ICR cell geometries have been investigated to increase the order of the harmonic frequencies and enhance harmonic signal intensities. In this study, we demonstrated PCB-based ICR cell designs with dipole and 6th harmonic detectors for parallel detection of fundamental and harmonic (6f) signals. The 6th harmonic signals from the 6th harmonic detector showed expected six-times higher resolving power with (M + 3H)3+ charge state insulin ions as compared with that from fundamental signals from the dipole detector. Moreover, the insulin isotopic peaks with 6th harmonic frequency signals acquired with the 6th harmonic detector were resolved for 40 ms data acquisition period, but unresolved with the same duration dipole detector signals, corresponding to a six-fold improvement in achievable spectral acquisition rates for a given resolving power.