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Plasma renin substrate in the prediction of pregnancy outcome in threatened abortion

Summary. Concentrations of plasma renin substrate, serum oestradiol‐17β, human chorionic gonadotrophin, sex‐hormone binding globulin and plasma renin activity were measured in 77 samples from 74 patients with uterine bleeding during the first and second trimesters of pregnancy and in a control group of 29 normal pregnant women (51 samples). Mean concentrations of these substances were lower than control values in patients with an abnormal outcome of pregnancy. In patients with a normal outcome after uterine bleeding, concentrations were mostly within the control range. Serum oestradiol‐17β concentration was superior to the other variables in predicting fetal outcome in the whole group. In patients with a live fetus at the time of blood sampling but who subsequently aborted, serum oestradiol‐17β concentration was mostly normal, whereas plasma renin substrate was decreased. Our results suggest that plasma renin substrate may provide additional prognostic information to that given by serum oestradiol‐17β measurement or ultrasonography in threatened abortion.