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OC23.02: Sonographic assessment of normal transient patterns of fetal cerebral lamination

VOCAL tool within 4D View (GE Medical Systems) was used to outline the placenta. The power Doppler signal within this volume was counted in a three-dimensional manner adapting the random but systematic techniques used in stereology. Results: The mean (SD) placental FrVolBV was higher in the non-diabetic than in the diabetic group at each gestation; 0.144 (0.05) versus 0.104 (0.03) at 20 weeks, 0.145 (0.05) versus 0.128 (0.03) at 24 weeks, 0.159 (0.05) versus 0.133 (0.02) at 28 weeks and 0.154 (0.03) versus 0.123 (0.04) at 32 weeks. There was a significant difference in FrVolBV between normal and diabetic subjects [F(1.31) = 5.396, P = 0.027] and across gestation [F(3.93) = 3.633, P = 0.016]. Conclusions: Placental FrVolBV is reduced in women with diabetes from 20 weeks gestation using this novel stereological technique. This contrasts with the known increase in volume of the villous vasculature determined histologically. Structural changes in the large and apparently vascular placenta are therefore accompanied by altered function, with reduced perfusion demonstrable in-vivo.