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[Long-term organ cultures of mouse primordial respiratory tract both intact and isolated from the mesenchyma].

Morphogenesis of long-term organ cultures of intact and isolated from mesenchyma murine respiratory tract (RT) was studied. Differences were detected in the growing potency of proximal and distal RT parts. The removal of mesenchyma was demonstrated to stop morphogenesis and decrease the growing potency of explants. In some RT explants isolated from mesenchyma focal hyperplasia of atypical basophilic cells sometimes with squamous cell metaplasia (with or without keratinization) was observed. Such atypical cells were capable of microinvasive growth into reconstructed connective tissue and of extensive growth on cellulose filter.