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[Mechanisms of disorders of immunoregulatory lymphocyte function in the atopic form of bronchial asthma].

Peripheral lymphocytes from 36 patients were used to study pathogenetic mechanisms of development of atopic bronchial asthma (ABA), which are associated with regulatory dysfunction of T lymphocytes. Models of determining immunoregulatory lymphocytic subpopulations (CD4+ and CD8+) and assessing the function of concanavalin A-induced immunoregulatory lymphocytes indicated that the reception of the immune mediators IL-2 and alpha-interferon was impaired in ABA patients. The paper gives the data on a significant drastic decrease in cAMP concentrations and an increase in cAMP levels in the peripheral lymphocytes in the patients. The findings suggest that there is an impaired turnover of cyclic nucleotides in the lymphoid cells of patients with atopy.