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AChR‐Specific Proliferative T‐Cell Lines: Helper Function, Ia Requirements, and Response to Interleukins

The pivotal cell in the development of an immune response to a thymus-dependent antigen like the AChR is the helper-proliferative T lymphocyte (Th). This cell provides the necessary “help” for optimal production of antibody to the antigen, and is the final common pathway through which regulatory influences pass. In most antigenic systems studied, the triggering of this cell requires the antigen in the context of class I1 antigens on the surface of “antigen-presenting” cells. The study of Th cells in autoimmunity is in its infancy-it is completely unclear whether this cell functions the same in the response to autoantigens as it does to “normal” antigens. In order to evaluate this question, we induced and maintained murine AChR-specific T-cell lines, and studied the response of these cells to antigen and the effects that these cells and their supernatants had upon AChR-primed B cells.