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Symmetry-Based Inhibitors of HIV Protease with Rigid P2 Amino Acid Mimics



Conformationally restrained amino acid replacements for the P2/P2' positions of symmetry-based inhibitors of HIV protease were designed beginning with the X-ray crystal structure of an enzyme-inhibitor complex. Synthesis and incorporation of (S,S)-2-aminocyclohexyloxycarbonyl ((S,S)-ACHOC) and (S,S)-2-aminocyclo­ pentyloxycarbonyl ((S,S)-ACPOC) groups at the P2 position provided inhibitors with equal potency to the parent P2-valinyl inhibitors.
