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Effects of Chloral Hydrate, γ‐Butyrolactone, and Equithesin on the Efflux of Dopamine and 5‐Hydroxytryptamine Metabolites into Cerebroventricular Perfusates of Rats

Abstract: Chloral hydrate, γ‐butyrolactone, and Equithesin are general anesthetics which have been employed in a variety of neurochemical and electrophysiological experiments. The effects of these anesthetics on the efflux of dopamine and 5‐hydroxytryptamine metabolites into lateral cerebroventricular perfusates were determined in rats bearing chronically implanted cannulas. Chloral hydrate and Equithesin increased, whereas γ‐butyrolactone decreased, the efflux of the dopamine metabolites 3,4‐dihydroxyphenylacetic acid and homovanillic acid. None of the anesthetics had a consistent effect on the efflux of the 5‐hydroxytryptamine metabolite 5‐hydroxyindoleacetic acid.