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Proliferative kinetics of human hematopoietic cells during different growth phases in vitro.

Summary The proliferation kinetics of an established human hematopoietic cell line (SK-L7) derived from the peripheral blood cells of a patient with acute myeloblastic leukemia were studied during different phases of cell growth with thymidine- 3 H and autoradiographic methods. As the population changes from logarithmic to stationary growth, the S, G 2 , and G 1 phases of the cell cycle become longer and more variable; G 1 is most affected, and an increased proportion of cells remain in G 1 . Both nutrient deficiency and the extent of cell confluence affect the cell cycle as the cultures approach saturation density; the changes are reversible if the cells are fed and their population density is reduced. The kinetic behavior of SK-L7 cells in many ways resembles that of leukemic cells in the marrow in acute leukemia, and this system may be a useful in vitro model to study growth-regulatory factors and chemotherapeutic effects.