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Stage-specific effects of antimalarials on an Indian isolate of Plasmodium falciparum.

In this study, effects of timed sequential exposure to various concentrations of chloroquine and its two metabolites (SA100387/050 B, SA 100487/053 B), quinine, hydroquinine and quinidine were monitored by morphological analyses, using synchronous cultures of Plasmodium falciparum. The trophozoites and schizonts were sensitive to chloroquine and its metabolites. However, quinine and two of its derivatives were lethal without particularly being stage-specific.