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Aspects of the migration of invasive parasitic juvenile nematodes in the tissues of laboratory rodents

Rigorous proof that a specific site is part of the migratory pathway of a skin penetrating nematode depends on the data satisfying the inequality Po + 2 > 1, where Po is the peak proportion of the dose found in the site, and P f the maximum proportion of the dose reaching the destination. It is shown that third stage larvae of Strongyloides ratti (two strains) applied in exact doses in the order of 20 to the skin of the rat can be extracted from the nasal region of the head in sufficient quantities to satisfy the criteria. The timing of the peak of the dose of larvae () in the nasal region was found to vary between the strains. The maximum proportion of the dose completing migration (2k) was quantified on days 5 to 8 by counting the number of egg-tracks present in the small intestine. With appropriate statistical tests, the excess of the sum of the means of these two proportions over unity is shown to be highly significant for both strains. Thus it is effectively certain that the nasal region of the rat head is part of a pathway taken by this parasite on its way from the skin to the intestine. Larvae of both strains were also recovered from the cranial region of the rat head but in insufficient numbers to satisfy the inequality. Nevertheless, the results combined with a histological study ,suggest events in the cranium precede those in the nasal region, with the two sites forming a single step on a specific pathway. Larvae of Nippostrongylus brasiliensis, applied to the skin of the rat in exact doses in the order of 20 partially sheathed L3's, were found in sufficient quantities in the lung (P-0 = 35h) to fulfil the inequality = adult worms in the small intestine on days