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Global and local administration of BDNF regulate dendrite patterning via different pathways

Appropriate dendrite patterning determines how information is received and processed by a neuron. Abnormal changes in dendrite number result in improper signaling between neurons. Dendritogenesis is regulated by extracellular and intrinsic factors, many of which have been characterized recently. Brain‐derived neurotrophic factor (BDNF) is one of the most studied extrinsic factors regulating dendrite outgrowth and branching. Our laboratory has previously shown that cypin (cytosolic PSD‐95 interactor), a guanine deaminase, increases dendrite number when overexpressed in cultured hippocampal neurons. We also found that global stimulation of BDNF alters proximal dendrite branching by transcriptional regulation of cypin, and cAMP response element‐binding protein (CREB) and mitogen‐activated protein kinase (MAPK) signaling pathways are involved in this action of BDNF. Here we show that local BDNF application has different effects on the dendritic arbor by using BDNF‐coated beads. These studies suggest that global and local exposure to BDNF results in different effects on dendritic arborization and that these effects are due to different signaling pathways.