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Problems in the phenotypic assessment of asthma

This paper will deal with five methodological problems in the phenotypic assessmetit of asthma. The first is the interrelationship between the two intermediate phenotypes. airway hyperresponsiveness and inflammation. The second is the issue of missing data. The third is the issue of single vs multiple phenotypes. The fourth is the lack of specific clinical phenotype, and the fifth is the issue of stability or variability of phenotype over time.