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Comparative study of the toxicity of hydroethanolic extracts of the root and stem barks of Cassia sieberiana D.C. on Wistar rats

This study was aimed to evaluate and to compare the acute and subchronic toxicities of the hydroethanolic extracts of root (EHER) and stem bark (EHEE) of Cassia sieberiana in rats. 
In acute toxicity study, animals were divided into 2 groups (n = 3). Rats received the single dose of 5000 mg / kg of EHER and EHEE extracts of Cassia sieberiana orally. For the subchronic toxicity, 4 groups (n = 6) were given daily 500 and 1000 mg / kg of extracts for 28 days. Animal behaviors were observed after each treatment. Results showed that EHER and EHEE were not toxic at 5000 mg / kg. The LD50 was greater than 5000 mg / kg for both extracts. After repeated doses of 500 and 1000 mg / kg, both extracts did not significantly affect the relative organs weight of treated rats. HEEE did not affect biochemical and hematological parameters. However, EHER significantly increased parameters such as red and white blood cells, hemoglobin, VGM, TCMH and triglycerides. This study showed that EHER and HEEE are not toxic. It contributes to a better knowledge of the toxicity of C. sieberiana used for the treatment of several diseases in Togo.