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[Stimulating action of cadmium on the Na-dependent transport of organic acid in the frog kidney].

Cadmium ions (10(-5)-10(-3) M) stimulate Na-dependent transport of a weak organic acid, fluorescein, into the proximal tubules of surviving frog kidney. Their stimulatory action ceases with increasing the duration of incubation to 45-60 minutes (stimulation does not disappear after introducing acetate into the incubating medium), in the presence of amiloride in the tubular lumen or in the absence of Na+ from the medium. The data obtained in the present work coincide with the previously reported evidence of the influence of Cd2+ on the Na-independent fluorescein transport into the proximal tubules of rat kidney. They are in good accordance with the suggestion that the effect of Cd2+ of the weak organic acid transport is mediated through an acceleration of the active reabsorption of Na+ with the accompanying activation of Na,K-ATPase.