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Mechanism of beta-blockade hypotension.

During the past two decades we have witnessed an increasingly sophisticated approach to the diagnosis and treatment of the hypertensive diseases. We no longer consider the elevated arterial pressure necessary to perfuse tissue ("essentielle Hypertonie"). To the contrary, epidemiologic and prospective clinical investigative studies have demonstrated the validity and effectiveness of antihypertensive therapy in reducing cardiovascular morbidity and mortality. Indeed, it is now possible to sort out specific pressor mechanisms (or diseases) that can be approached specifically with therapy. Thus, patients may be characterized according to hemodynamic criteria as well as those of intravascular volume, plasma renin activity, and aldosterone . . .