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The effect of α2‐adrenoceptor agonists on the acid secretory responses of rat isolated gastric mucosa to electrical field stimulation

1 The effects of clonidine, UK‐14,304, noradrenaline, para‐aminoclonidine and phenylephrine were examined on the acid secretory response of the rat isolated gastric mucosa preparation to electrical field stimulation. 2 Clonidine, UK‐14,304, noradrenaline and para‐aminoclonidine but not phenylephrine (10 μM) reduced the response of the gastric mucosa stimulated at 2.5 Hz; gastric mucosae stimulated at higher frequencies were insensitive to the action of these α2‐adrenoceptor agonists. 3 The inhibitory effect of the selective α2‐adrenoceptor agonist UK‐14,304 was antagonized by idazoxan but not by prazosin. 4 These findings indicate that clonidine and other α2‐adrenoceptor agents inhibit the acid secretory response of the rat gastric mucosa to electrical field stimulation by an action at α2‐adrenoceptors, which are probably located on cholinergic nerve terminals.