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Analysis of Planar Circular Interdigitated Electrodes for Electroporation

ABSTRACT In this work, designs for planar, interdigitated circular electrode structures for cell membrane permeabilization procedures are analysed using finite element method analysis. The generated electric field intensity, homogeneity, and the Joule heating are evaluated. The optimal electrode configuration for successful transfection procedures is investigated. Based on the simulation results, an optimized design for the electrodes, suitable for the investigation of the permeabilization thresholds during electroporation is proposed. The Joule heating influence simulation results are validated experimentally.