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Pachydermoperiostosis with Angiolymphoid Hyperplasia with Eosinophilia

To the Editor: We observed a case of pachydermoperiostosis with angiolymphoid hyperplasia with eosinophilia. To our knowledge, this association has not been reported previously. Case Report: A 62-year-old man visited our clinic with clubbed fingers (Fig. 1) and slightly elevated, well demarcated, indurated, erythematous lesions on his face and palms which had developed 8 months previous to his visit. Roentgenographic studies of the extremities showed periostosis with cortical thickening of the long bones. A diagnosis of pachydermoperiostosis was made. An electrocardiogram was normal. The percent of one second forced expiratory volume and vital capacity were within normal limits. Microscopic examinations ofbiopsy specimens from the patient's right cheek and left palm showed vascular proliferation with plump endothelial cells and dense infiltrations of Fig. 1. Clubbing of the fingers..