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T H E BACTERICIDAL ACTION OF H U M A N SERUM ON HEMOLYTIC STREPTOCOCCI I. OBSERVATIONS MADE WITH SERUM FROM PATIENTS WITH ACUTE INFECTIONS AND FROM NORMAL INDIVIDUALS

The results presented in this communication concern the destructive action upon hemolytic streptococci of serum from patients who are acutely ill. Successive samples of serum have been obtained from representatives of a number of different kinds of infectious diseases, both during acute illness and following recovery, and determinations of bactericidal power have been made by the use of different strains of Streptococcus hemolyticus of the beta type. The several specimens, of sera have exhibited marked differences in streptococcidal potency which may be correlated with the condition of the patient at the time at which the blood was obtained. The results which are described in detail in this article were obtained with sera from twenty-five adult patients acutely ill with different infections. The list is as follows: