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High dose chemotherapy in ovarian cancer

The rationale for intense therapy in ovarian cancer is based on preclinical observations in experimental models as well as upon retrospective studies correlating the impact of dose intensity upon response rate and survival. Skipper summarized the results of extensive experimental studies of chemotherapy treatment of murine tumors with the following conclusions: 1) dose intensity is the most important factor with respect to cure in drug sensitive tumors and 2) total dose correlates best with the duration of response of tumors not amenable to cure by chemotherapy. Ovarian cancer is a chemosensitive disease and we can expect that Skipper’s experimental conclusions would carry over to the clinical situation.