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The etiology and prediction of breast cancer. Fourier transform‐infrared spectroscopy reveals progressive alterations in breast DNA leading to a cancer‐like phenotype in a high proportion of normal women

Background. The authors previously have shown by gas chromatography‐mass spectrometry that the hydroxyl radical (.OH) induces alterations in the DNA base structure of the female breast, which are premalignant markers of breast cancer. Fourier transform‐infrared (FT‐IR) spectroscopy also has a high potential for revealing a broad array of structural changes in DNA that may provide important new insight into breast cancer etiology and prediction.