{'fraction_non_alphanumeric': 0.025870646766169153, 'fraction_numerical': 0.0009950248756218905, 'mean_word_length': 5.843537414965986, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Establishing a "Ring Size-Divergent" Synthetic Strategy: Synthesis, Structural Revision, and Absolute Configuration of Feroniellins.

Feroniellin analogs isolated from Feroniella lucida possess a furanocoumarin skeleton connected with monoterpenic five- to seven-membered ethereal rings by an ether linkage and exhibit a broad spectrum of biological activities. In this contribution, we intended to establish a "ring size-divergent" synthetic strategy for the monoterpenic five- to seven-membered ethereal rings through the chemical sythesis of feroniellins. Herein, we report the short and comprehensive synthesis of feroniellins has been achieved in only 2 steps from easily available bergamottin based on the "ring size-divergent" strategy. In addition, these syntheses resulted in revision of the proposed structures for feroniellins A and B and the determination of all the absolute configurations of feroniellins, and further their preliminary anti-inflammatory activities were investigated as well.