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Eigen analysis on ultrafast FMRI data shows altered dynamic functional connectivity in MCI individuals

Resting state functional connectivity (rsFC) is a powerful tool to detect brain dysfunction. Recent studies show that resting state networks are not static, but dynamic and alter connectivity in seconds. The use of simultaneous multislice imaging technology allows sub‐second fMRI acquisitions in ADNI3. We leverage eigenanalysis to compare brain connectivity states and their temporal dynamicity between cognitive normal older adults (NC) and MCI participants.