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4Dimensional X Strain and 2Dimensional Speckle Tracking Echocardiographic Study: Normative Values of Strain Parameters of Left Ventricle and Tissue Doppler Imaging of Ascending Aorta in Healthy Adults –A Single Centre Indian Study

Global longitudinal strain (GLS) is a sensitive measure of LV dysfunction and is better than EF at predicting CVD events and deaths. Recently 3D/4D/4D X strain speckle tracking echocardiography (STE) is used to analyse complex LV mechanics. Interestingly, HFpEF is related to both GLS and increased Aortic stiffness. TDI of ascending Aorta is an effective technique to assess Aortic stiffness. The aim of the present study is to establish normal values of TDI of AA by 2DE and 4D X-strain volumetric and strain parameters of LV of healthy adults. 102 subjects were enrolled, 72 assessed by 2DE-GROUP-A, and 30 were analysed by 4D X-strain echocardiography-GROUP-B. Important TDI parameters of Aortic stiffness were 3.90 ±3.79& 5.23 ± 10.55, (p = NS), in males & females respectively and Aortic strain were 10.55 ± 7.67% and 9.49 ± 5.56%, (p = NS), in males & females respectively. Volumetric data of EF were 64 ± 7.0 % & 65 ± 6.0 %, (p = NS), in males & females respectively and CO were 5.6 ± 1.5 l/min & 4.91±1.53l/min, (p = NS), in males & females respectively. Moreover, 4D X-strain STE indices of GLS being -17.29 ± 2.71 & -19.00 ± 3.51, (p = NS), in males & females, respectively GCS being -15.46 ± 7.1 & -14.12 ± 6.15, (p =NS), in males & females respectively and GRS being -24.53 ± 9.8 & -21.93 ± -8.81, (p= NS), in males & females respectively. No previous data is available, making the research a singular experience.