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Prophylaxis of placental insufficiency and other complications of gestation in women with diseases associated with endothelial dysfunction

The pathogenesis of placental insufficiency and other complications of gestation is associated with vascular endothelial dysfunction. Glycocalyx covering the endothelium plays a fundamental role in coagulation and fibrinolysis. The presence of low molecular weight glycosaminoglycans in glycocalyx has a protective effect. The proven clinical efficacy of sulodexide to correct vascular endothelial dysfunction, prevent placental insufficiency and other pregnancy complications makes it a promising tool for use in obstetric practice among patients with chronic diseases (arterial hypertension, diabetes, obesity, etc.), autoimmune pathology, thrombophilia and related pregnancy complications (gestational diabetes, hypertension in pregnant women, pre-eclampsia, recurrent miscarriage, fetal growth retardation).