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ABOUT DISCUSSION QUESTIONS OF DRUG DISEASE DIAGNOSTICS AS AN INTERDISCIPLINARY PROBLEM

The objective of the study – to detect drug sensitization in patients with diffuse dermatoses and complicated allergic anamnesis and to analyze drug spectrum. Materials and methods. 195 patients with drug disease and diffuse dermatoses followed by complicated allergic anamnesis were observed. Drug sensitization was detected by ultrasonic test, agglomeration reaction of leucocytes and rate of erythrocyte sedimentation in the presence of drug. Results. There were detected 23.60% of patients with drug disease, 12.30% with eczema, 11.30% with food toxidermy, 13.80% with psoriasis, 12.80% with atopic dermatitis, 26.20% with other dermatoses. Drug sensitization was detected in 70.80% patients with eczema, 22.70% with food toxidermy, 44.40% with psoriasis, 72.0% with atopic dermatitis, 60.80% with other dermatoses. The most frequently detected sensitization was registered to such drugs as antibiotics (24.60%), cardiovascular (17.40%) and hypotensive (15.40%) medicines, local anaesthetics and analgetics (15.90%), anti-inflammatory (12.30%) medicines, vitamins (13.80%), gastrointestinal medicines (11.30%), corticosteroids (5.10%) and antihistamines (4.10%). Conclusions. 1. Drug sensitization was most frequently detected in patients with eczema, atopic dermatitis and psoriasis. 2. Drug disease was caused in patients with diffuse dermatoses by polysensitization to such drugs as antibiotics (24.60%), cardiovascular (17.40%) and hypotensive (15.40%) medicines, local anaesthetics and analgetics (15.90%), anti-inflammatory medicines (12.30%), vitamins (13.80%), gastrointestinal medicines (11.30%), corticosteroids (5.10%) and antihistamines (4.10%). 3. Drug disease is an interdisciplinary problem because it was detected to the different groups of drugs in patients with diffuse dermatoses both by dermatovenerologists and doctors of all specialties