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Haematological toxicity of drugs used in psychiatry

Almost all classes of psychotropic agents have been reported to cause blood dyscrasias. Mechanisms include direct toxic effects upon the bone marrow, the formation of antibodies against haematopoietic precursors or involve peripheral destruction of cells. Agranulocytosis is probably the most important drug‐related blood dyscrasia. The mortality from drug‐induced agranulocytosis is 5–10% in Western countries. The manifestations of agranulocytosis are secondary to infection. Aggressive treatment with intravenous broad‐spectrum antimicrobials and bone marrow stimulants may be required.