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Expression and Function of CD 40 on Hodgkin and Reed-Sternberg Cells and the Possible Relevance for Hodgkin ’ s Disease

CD40 was originally described as a B-cell-restricted antigen and was subsequently found to be a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 is also expressed on dendritic cells, thymic epithelium, monocytes, and some carcinoma cell lines, and plays critical role in cell contact-dependent activation. Primary and cultured Hodgkin and Reed-Sternberg (H-RS) cells, the presumed malignant cells of Hodgkin‘s disease (HD), were found to express high levels of cell surface CD40. We found that recombinant CD40 ligand (CD40L) induced interleukin8 (IL-8) secretion and enhanced IL-6, TNF, and lymphotoxin-a (LT-a/TNF-8) release from cultured H-RS cells. These cytokines play a significant role in the clinical presentation and pathology f HD, a tumor of cytokine-producing cells. CD40L had no mitogenic activ-