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Ioglycamide Induced Release of Testosterone and Estradiol from Protein Bound Stores

With the use of an aqueous two-phase system the effect of ioglycamide (Bilivistan) on the binding of testosterone and estradiol to albumin and testosterone-estradiol-binding globulin was investigated using whole human serum. Reduced binding capacity was recorded for TeBG and a reduced apparent association constant for the testosterone-albumin binding was recorded in the presence of ioglycamide in high concentration. The significance of reduced binding of testosterone and estradiol to albumin and TeBG was discussed in relation to side-effects of radiographic contrast media.