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MODERN POSSIBILITIES OF MEDICAL CORRECTION OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE IN THE INTRAOPERATIVE AND EARLY POSTOPERATIVE PERIOD AFTER MYOCARDIAL REVASCULARIZATION

Background: Endothelial dysfunction is the main link in the development of cardiovascular diseases, which leads to ischemic heart disease (coronary artery disease) and its complications. There are many medicines available for the treatment of coronary artery disease. However, not all groups of drugs are able to positively affect endothelial function. Purpose. Based on the literature data, to study the effect of the main groups of drugs for the treatment of coronary artery disease on endothelial function and systemic hemodynamics in cardiac surgery patients after myocardial revascularization. Material and methods: The review and analysis of literature data from 46 sources are presented. Results: Angiotensin converting enzyme receptor inhibitors, calcium sensitizers, phosphodiesterase type III inhibitors as well as beta blockers have a positive effect on endothelial function. Nitrates have a negative effect on its function in conditions of critical circulation and should be used with caution in endothelial dysfunction. Conclusion: The data obtained indicate a positive effect of angiotensin converting enzyme receptor inhibitors, calcium sensitizers, type III phosphodiesterase inhibitors and beta blockers on endothelial function. However, these groups of drugs can negatively affect systemic hemodynamics in the perioperative period, which requires a deliberate approach when prescribing them.