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Aging impairs renal autoregulation

Renal autoregulation maintains renal blood flow (RBF) and glomerular filtration rate constant over a wide range in systolic blood pressure. Renal autoregulation is primarily regulated by two mechanisms, which are myogenic and tubuloglomerular feedback (TGF) responses. Although evidence from experimental and clinical studies suggested that aging may impair vasoregulatory mechanisms, age‐related alterations in renal autoregulation remain elusive. In the present study, we hypothesized that aging impairs renal autoregulation by altering both myogenic response and TGF. To test our hypothesis, autoregulation of RBF, myogenic response in isolated afferent arteriole (Af‐Art) and TGF response in vivo were measured in young (3 months) and aged (24 months) C57BL/6 male mice.