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Mechanisms underlying the increase in mycobacterial infections in cystic fibrosis patients on azithromycin

This study investigated the increased incidence of non-tuberculous mycobacterium (NTM) infections in cystic fibrosis (CF) patients on azithromycin. The authors were particularly interested in autophagia, a process whereby intracellular material is isolated into phagosomes and then destroyed by being fused with acid-rich lysosomes. It is disrupted by other macrolides and is crucial for the clearance of intracellular …