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Purinoceptor mediated stimulation of prostacyclin release in the porcine pulmonary vasculature

1 Prostacyclin (PGI2) release from the piglet isolated perfused lung was measured by radioimmunoassay of 6‐keto‐PGF1α in the venous effluent. 2 Basal release of PGI2 was transiently stimulated up to 30 fold, in a dose‐dependent manner, by bolus injections of ATP (0.03–3 μmol). A continuous infusion of ATP also produced a transient response. 3 Dose‐response curves for purinergic stimulation of PGI2 release showed that ADP was equipotent with ATP, while AMP and adenosine were virtually inactive. 4 The non‐hydrolyzable ATP analogue, ATP‐γ‐S, elicited PGI2 release of similar magnitude and duration to that of ATP, suggesting that pulmonary catabolism of ATP is not required to induce PGI2 release. 5 The results suggest that the porcine pulmonary vasculature possesses P2‐purinoceptors through which the synthesis and release of PGI2 can be mediated.