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Immunopathological changes during immunosuppressive treatment of glomerulonephritis in systemic lupus erythematosus.

. Fluorescent microscopy examination of up to 4 consecutive renal biopsies has been performed during combined therapy with azathioprine and prednisone in each of 7 patients with SLE and glomerulonephritis. The changes in the immunopathological picture after treatment showed good correlation to the changes in renal function. In 2 cases a progression of immunofiuorescent changes corresponded well to a progression of renal insufficiency. The pattern of immunofluorescence microscopy and renal function was unchanged in 2 other cases. In 2 cases an improvement in the immunopathological findings corresponded with an improvement in renal function. One patient died shortly after the commencement of the treatment. Progression was seen particularly in the cases in whom the initial immunofluorescence pattern was very lumpy. In contrast, the immunosuppressive therapy had the best effect in the cases with focal or diffuse granular immunofluorescence patterns.