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Can the combination of lithium and olanzapine be an effective treatment strategy in the management of bipolar disorder with Wilson′s disease?

Wilson′s disease is a disorder of copper metabolism, which frequently has neurobehavioral manifestations due to the involvement of the central nervous system (CNS). Depression is the commonest neuropsychiatric manifestation; however, recent studies have revealed the association of bipolar disorder with Wilson′s disease. Lithium is a safe and efficacious medication in the management of bipolar disorder in Wilson′s disease. Our case report highlights the efficacy of the combination of lithium and olanzapine in the management of bipolar disorder in the context of Wilson′s disease.