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Differential effects of apolipoprotein E on the molecular and cellular phenotypes associated with Alzheimer’s disease in isogenic human iPSC‐derived neurons

Apolipoprotein E4 (APOE4) is an established AD risk gene, while APOE2 is considered protective. Recently, several studies demonstrated that APOE4 can induce AD‐related pathological phenotypes including tau phosphorylation (p‐tau), neuroinflammation, and tau‐mediated neurodegeneration in both mouse models and human neurons. However, the underlying mechanism of APOE4 in AD pathology and how other APOE isoforms affect the molecular and cellular phenotypes associated with AD are not well understood in human cells. In this study, we used isogenic human induced pluripotent stem cell (iPSC)‐derived neurons to explore the differential effects of APOE isoforms on AD‐related pathology.