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Evaluation of the synergistic effect of cinnamon extract and honey against multidrug-resistant isolates of Pseudomonas aeruginosa recovered from burn unit

Methods: The minimum inhibitory concentration (MIC) and minimum bactericidal concentrations (MBC) of each antibiotic (Gentamicin and Ciprofloxacin) alone or in combination with the aqueous and alcoholic extracts of cinnamon and honey was determined by broth microdilution method for clinical and environmental isolates of P. aeruginosa based on the Clinical & Laboratory Standards Institute (CLSI) guidelines. The synergisticeffectof combinations was evaluatedusing a checkerboard test.Data analyzed using chi-square and Fisher’s exact tests (SPSS software). P-value of less than 0.05 was considered to indicate statistically significant differences.