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Animal on a chip: a microscale cell culture analog device for evaluating toxicological and pharmacological profiles

With the increasing rate of discovery of new potential pharmaceuticals, an accurate high throughput screening method is needed to provide toxicology and pharmcology profiles of chemicals. This can be done using a cell culture analog device which uses interconnected tissue cultures to represent different organ systems in animals. A working prototype of microscale cell culture analog (CCA) device has been constructed. Cells cultured in the system have been shown to be viable for more than 24 hours. In this paper, we will present the development of this microscale CCA device as well as the integratable micropump we have created to produce the recirculating flow.