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Study on Protection of TGM on Acute Myocardial Ischemia of Mice

Objective :To study the effect of the total glucosides of Mudan cortex(TGM)protecting acute myocardial ischemia of mice caused by pituitrin,the influence on CK in myocardial tissue,the influence on LDH in myocardial tissue. To observe the protection function of TGM for acute myocardial ischemia injury. Methods :The myocardial ischemia model of mice was set up,and the changes of the electrocardiogram were observed and the contents of CK and LDH were determined,and the damage degree of mice was observed. Results :The contents of CK and LDH in the myocardial tissue were significantly higher than those of the normal group(P0.01),and those of medium and high dose groups were significantly reduced(P0.01). High and medium dose can significantly narrow the red dye area. Conclusion :Total glucosides of Mudan cortex(TGM)obviously changes the mice's J point of displacement of ECG caused by isoproterenol,reduce CK content in serum,lower LDH content in the heart muscle tissue. So it can protect mice's heart muscle tissue.