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Evaluation of Bone Mineral Density in Children with Hemophilia A in Benha Insurance Hospital

Background; children with HA have decreased physical activity and are at higher risk for hemoarthrosis (75% to 90% of kids with HA), Hepatitis C, and other blood-borne diseases. All of these may lead to osteoporosis and a lack of vitamin D. The objective of this research was to evaluate the bone mineral density of children with haemophilia A. Methods: This case-control research was conducted on 60 people. The control group consisted of 30 instances involving haemophilia A and 30 healthy youngsters. In all patients included, comprehensive history was taken, thorough clinical review, labouratory evaluation of CBC, Ca, and vit. D and BMD were evaluated in the lumbar spinal area (L2-L4) using dual energy X-ray absorptiometry (DXA). Results: in patients (16.6 ng/ml), vitamin D3 was much lower than the controls (23 ng/ml). The value of P was <0.001. In patients (8.1 mg/dl) serum ca was considerably lower than controls (9.5 mg/dl). P-value was less than 0.001. Median DEXA z score in the case (-1.4) was much lower than controls (0.8). P-value was less than 0.001. DEXA Z score exhibited strong positive PAS relationships (r=0.730 & P <0.001), Vitamin D3 (r=0.693 & P <0.001) and ca (r =0.786 & P <0.001), while no significant connection between the DEXA Z score and the DEXA Z score exists (age, weight, height, BMI, WBCs, HCT, Hb, platelets, PT, PTT, INR). Conclusion: in hemophilic patients, vitamin D calcium and BMD were substantially reduced, and DEXA Z was shown to have strong positive associations to PAS, to vitamin D3, and approx.