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Osteoporosis in severe congenital neutropenia treated with granulocyte colony‐stimulating factor

Recombinant human granulocyte colony‐stimulating factor (G‐CSF) has substantially improved life expectancy for children with severe congenital neutropenia (SCN). Severe osteoporosis, reported in this population, may relate to the disease process, or be a therapeutic side‐effect. This report details bone loss, quantitated absorptiometrically and histomorphometrically, in a child with SCN and vertebral collapse, and the positive response to anabolic steroid and bisphosphonate therapy.