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Effects of in vivo and in vitro administered thyroxine on substrate metabolism of isolated rabbit ventricle mitochondria. 3. Substrate effects on pyridine nucleotide reduction, on the reversal of electron transport, and on the "respiratory control by ATP".

Ventricle mitochondria have been isolated and assayed from normal and from thyroxine-treated, initially normal rabbits (20 μg T4 administered sc per 100 g body wt per day, for 1, 4, or 14 consecutive days). Repeated T4 treatment in vivo generally increased the net rate and degree of “succinate-linked” NAD reduction, as it did the QO2 of controlled and active states in the presence of succinate. After 4–14 T4 injections in vivo, the “succinate-linked” controlled state showed neither ATP requirement for NAD reduction nor respiratory inhibition by ATP, whereas both these phenomena were observed prior to hormone treatment. Nevertheless, in the succinate-linked active state, ATP inhibited the QO2 and augmented the NAD reduction, unaffected by T4 treatment. Rotenone inhibited the “succinate-linked” NAD reduction in all preparations. D( + ) Malate inhibited the “succinatelinked” NAD reduction irrespective of T4 treatment. Ninety second preincubation of euthyroid mitochondria with cysteine sulfinate, pyruvate, or...