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Risk factors for salmonella infection: Loss of gastric acid linked to candidiasis

EDITOR, - Keith R Neal and colleagues report that recent treatment with H2 antagonists and gastric surgery predispose to salmonella infection, presumably as a result of reduced production of gastric acid.1 A protective effect of gastric acid against the non-typhoid salmonelloses has been suspected.2 Another potential infective complication of reduced secretion of gastric acid is candidiasis.

There have been anecdotal reports of both local and systemic candidal infections after various interventions that produce …