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Comment: Serum Concentrations of Cefuroxime after Continuous Infusion in Coronary Bypass Graft Patients

TO THE EDITOR: Pass et al. (2001;35:409-13) describe a study of serum concentrations of cefuroxime, administered by continuous infusion, in coronary bypass graft patients. The stated objective of this study was to describe the serum concentrations of this antibiotic and to assess the incidence of sternal wound infection in this group of patients. As the authors rightly point out, both the design of the study and the small number of patients enrolled do not allow any firm conclusion to be drawn regarding the clinical efficacy of this regimen. However, it is the use of total drug concentrations that we find most interesting. In describing total, rather than unbound, drug concentrations, Pass et al. have Letters