{'fraction_non_alphanumeric': 0.021904761904761906, 'fraction_numerical': 0.021904761904761906, 'mean_word_length': 5.146198830409356, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Validated Method for the Determination of Five Membered Heterocyclic Polar Compound Imidazole in Drug Substances Using Capillary Electrophoresis and UV Detection

A simple and sensitive method based on capillary electrophoresis with UV detection was developed, optimized, and validated for the determination of five membered heterocyclic polar compound, imidazole in pharmaceutical drug substances. Separation was achieved on bare fused silica capillary using a simple running buffer, potassium dihydrogen phosphate at pH 4.0. Capillary temperature set at 25°C. The applied voltage was 25 kV across the capillary and the samples were injected by hydrodynamically at a pressure of 50 mbar for 5 s. Analyte was monitored at 210 nm. The achieved limit of detection value was 0.005%w/w, limit of quantification value was 0.014%w/w, and the average accuracy value was 98.4% for imidazole. The aim of present study is to develop a specific and sensitive method for the determination of imidazole to overcome the void volume and sample matrix interferences.