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The role of interleukin-10 in patients with HCV infection.

The aim of investigation was to study cytokine-producing ability of blood immune cells in type of viral hepatitis C, correlation with the degree of hepatic lesion and liver cirrhosis. 130 patients were investigated: 72 with cirrhosis: among them 10 - with stage A, 14 - with stage B and 48 - with stage C. The study demonstrates significant changes of cytokine-producing ability of blood immune cells type of viral hepatitis C, correlation with the degree of hepatic lesion and liver cirrhosis. The results showed that various types of chronic viral hepatitis C and stages of cirrhosis were associated with misbalance in production of anti-inflammatory cytokine, i.e. a significant rise of interleukin-10 concentration, which were the most prominent in cases of severe hepatic lesion.