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FOR THE DETERMINATION OF DICLOFENAC DIETYLAMINE

Simple, sensitive and convenient spectrophotometric methods (method A and method B) are developed for the determination of diclofenac diethylamine (DDEA) in pure form and in formulations. Method A is based on the oxidation of drug by Fe(III) followed by the complex formation between reduced form of Fe(III) with 1,10-phenantroline. The resulting red colored chromogen is measured at 510 nm. Method B is based on the formation of charge transfer complex between DDEA (n-donor) and pchloroanilic acid (π-acceptor) in 1,4-dioxane. The resulting violet colored chromogen is measured at 526 nm. Beer’s law obeyed in the concentration range of 2.00-8.00 and 20.00-120.00 μg mL -1 for the method A and B, respectively. The molar absorptivity and Sandell’s sensitivity are found to be 0.98 × 10 4 , 1.62 × 10 3 L mol -1 cm -1 and 3.77 × 10 -2 , 2.27 × 10 -2 μg cm -2 for the method A and B, respectively. The optimum reaction conditions and other analytical parameters are evaluated. Statistical analysis proves that both the methods are reproducible and selective for the determination of DDEA in pure and in dosage form. INTRODUCTION: Diclofenac diethylamine (DDEA) chemically, N-ethylethanamine 2-[(2,6dichlorophenyl)amino]benzeneacetate (Figure 1) is a powerful non-steroidal anti-inflammatory drug (NSAIDs) 1 , which has been most commonly used to reduce inflammation and local pain 2 associated with muscle or joint injuries such as sprains, strains, or sports injuries. It is used for topical application 3 and mainly used to relieve acute pain. DDEA is a prostaglandin synthetase enzyme inhibitor 4 and has many advantages such as less adverse reaction, small dose and little individual difference and so on.