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Intracellular immunoglobulin G ‘Pseudocrystals’ in a patient with chronic B‐cell leukemia

A patient with chronic B‐cell leukemia in whom the malignant lymphocytes showed intracellular inclusions of immunoglobulin (Ig) G kappa molecules is described. Electron microscopy revealed filamentous material in the nuclear envelopes and in the cisternae of the rough endoplasmic reticulum. These in vivo surface Ig‐negative, nonexcreting cells could be stimulated in vitro to excrete immunoglobulin‐free light chain molecules into the supernatant, which were not found in the cytoplasm after stimulation. Cancer 58:43–51, 1986.