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Coronary Risk Factors and Oxidative Stress in Women with PCOS

Introduction: Polycystic ovary syndrome (PCOS) affects 5–10% of women in reproductive age. It is associated with metabolic syndromes and non-metabolic disorders. Women with PCOS have dyslipidemia and oxidative stress representated by elevated serum Malonaldehyde (MDA) levels. These features are risk factors for development of atherogenesis and cardiovascular disease (CVD). Materials and methods: A case-control study was conducted at the Department of Biochemistry, Koppal Institute of Medical Sciences, Koppal, India. It included 100 diagnosed PCOS patients (50- obese and 50 non-obese) and 100 controls (50-obese and 50 non-obese) in the age group of 18-40 years. The mean±SD were compared using student‘t’ – Test from the SPSS Statistics Data Editor version 21. Kruskal–Wallis test was employed for p values. The p value of <0.05 is considered statistically significant. Results: Serum levels of total cholesterol, serum triglyceride, LDL, VLDL were higher in women with PCOS irrespective of BMI with p value of <0.001.There were low levels of serum HDL in women with PCOS irrespective of BMI with p value of <0.001. Serum MDA levels were higher in women with PCOS irrespective of BMI with p value of <0.001. Conclusion: Dyslipidemia and increased OS indicated by elevated levels of MDA are seen in women with PCOS irrespective of BMI. Hence, PCOS women should be evaluated for lipid profile and oxidative stress and should be treated with antioxidant supplementation, which can be beneficial in preventing coronary vascular diseases.