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Benign Cephalic Histiocytosis: Report of Four Cases

Abstract: We cared for four patients with benign cephalic histiocytosis, a self‐healing non‐X, nonlipid cutaneous histiocytosis of children. The age of onset of the disease was 5 to 9 months, with papules and erythematous macules Involving the head (mainly the cheeks), and posterior spread to the trunk and limbs in three patients. Microscopic examination of skin biopsies revealed a histiocytic infiltrate in the superficial dermis that was S100 protein‐negative by immunoperoxidase (PAP method). One patient showed comma‐shaped bodies and desmosomelike junctions on electron microscopy. No Birbeck's granules were present. Benign cephalic histiocytosis is a self‐limiting condition that requires no treatment.