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Effect of Anxiolytics on Cognitive Flexibility in Problem Solving

Objective:Our purpose is to examine the effect of different classes of anxiolytics on cognitive flexibility. Background:Situational stressors and anxiety impede performance on “creativity” tests requiring cognitive flexibility. Noradrenergic agents have been shown to modulate cognitive flexibility as assessed by performance on anagrams. To determine whether these findings on noradrenergic modulation of cognitive flexibility are specific to the noradrenergic system or are a nonspecific anxiety effect, we compared the effects of propranolol, lorazepam, and placebo on the anagram task. Methods:Subjects attended 3 test sessions. Prior to each session, subjects were given 1 of the 3 drugs. As in previous research, the natural log of the solution latency of each test item was summed for each test session and compared across drug conditions. Results:For subjects able to solve the anagrams, solution times after propranolol, but not lorazepam, were significantly lower than after placebo. Conclusions:Therefore, this suggests that the phenomenon of noradrenergic modulation of cognitive flexibility does not result from a nonspecific anxiolytic effect, but rather is specific to the noradrenergic system.