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e0101 Interleukin-17A gene variants and risk of coronary artery disease:a large angiography-based study

Objective Recent studies have also revealed that interleukin (IL)-17A plays a key role in atherosclerosis and its complication, but the relationship of its common variants with coronary artery disease (CAD) has not been extensively studied. Methods We systematically screened sequence variations in the IL17A gene and designed an angiography-based case-controlled study consisting of 1031 CAD patients and 935 control subjects to investigate the association between the selected polymorphisms of IL-17A gene and CAD risk in Chinese Han population. Results Frequencies of IL17A rs8193037 GG homozygote and G allele were significantly higher in the patient group than those in the control group (p<0.001; OR=0.68; 95% CI 0.54 to 0.85). Stratification analysis showed that the IL17A rs8193037 G allele significantly increased the risk of CAD only among male subjects (p=0.001; OR=0.63; 95% CI 0.47 to 0.83). After adjustment for conventional risk factors, binary logistic regression analysis showed that the the G allele carriers (GG +AG) had significantly increased CAD risk compared with the AA homozygotes (adjusted p<0.001; OR 0.43; 95% CI 0.33 to 0.58). ELISA showed augmented IL17A production in serum of the AMI patients. Conclusions Based on our data, we speculated that rs8193037 of IL17A is associated with CAD risk in Chinese Han population and G allele of rs8193037 may be an independent predictive factor for CAD.