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[Effect of iodglycol paste containing 20% Guaiacol on periodontal pockets].

The purpose of this study was to evaluate the effect of topically applied Paste containing 20% guaiacol (Gu-JG) on gingivitis and marginal periodontitis in humans and on experimental periodontitis in dogs. The bleeding index was mainly used as the clinical parameter of gingival inflammation. Bacterial plaque samples were examined under a dark-field microscope. The bleeding index for the group theated with GuJG was less than that of the untreated group in gingivitis and marginal periodontitis in humans. In experimental periodontitis, Gu-JG was effective in reducting the bleeding index, gingival index, probing depth and gingival crevicular fluid flow. Changes in microbial composition, i.e. reduction in the proportion of spirochetes and motile rods, were observed only in the pockets in which GU-JG was administed. Antimicrobial activity of GU-JG against B. gingivalis, C. ochracea and H. actinomycetemcomitans was observed in vitro. It was concluded that Gu-JG had an anti-inflammatory effect mainly due to inhibition of microbial growth in periodontal pockets.