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Neuropeptide Y Y2R blockade in the central amygdala reduces anxiety‐like behavior but not alcohol drinking in alcohol‐dependent rats

Electrophysiological data suggest a dual role of Y2 receptors (Y2Rs) as autoreceptors regulating neuropeptide Y release and heteroceptors regulating gamma‐aminobutyric acid release in the central amygdala (CeA). Here, we report that neither systemic (JNJ‐31020028) nor intra‐CeA (BIIE0246) Y2R antagonism altered operant alcohol responding by alcohol‐dependent or non‐dependent rats. Conversely, BIIE0246 in the CeA reduced anxiety‐like behavior in alcohol‐dependent and alcohol‐naïve rats. The finding that Y2R antagonism reduces anxiety‐like behavior but not alcohol drinking suggests that these two effects may occur via different functions of the Y2R (e.g. autoreceptor versus heteroceptor function).