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Avoiding the bad and enhancing the good of soy supplements in breast cancer.

Epidemiology teaches us that there is an inverse relationship between soy consumption in Asian countries and a decrease in breast cancer risk. Naturally, this observation sparked a sustained interest in a potential natural approach to the chemoprevention of breast cancer. However, there are many interconnected dimensions to the soy story, some of which are potentially bad. This is the focus of the study by Shike and colleagues (1) in this issue of the Journal.