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In this issue

Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality and involves multiple genetic changes. Fbxw7 is a tumor suppressor gene that is often suppressed in HCC. In this issue, Imura and colleagues report the clinical signifi cance of Fbxw7 expression in HCC. As expected, Fbxw7 expression was lower in HCC tissues than the adjacent non-tumor liver tissues. Importantly, low Fbxw7 expression in HCC tissues was associated with lower disease-free survival (5-year survival 53% in the high-expression group and 20% in the low-expression group). Fbxw7 expression remained associated with tumor recurrence after adjusting for tumor staging. Future studies are needed to determine the role of this genetic marker in combination of other known prognostic factors in the management of patients with HCC.