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Prolactin Release in Depression

as indicating decreased 5-HT function. We have investigated an alternative explanation, that PRL secretion itself is impaired in depression, by measuring the PRL responses to the dopamine antagonist, metoclopramide (MCP)(0.3mg), and to thyrotropin releasing hormone (TRH)(6.25ug) in drug free depressed patients. Both drugs stimulate PRL secretion by a direct action on the pituitary and in the doses used produce submaximal PRL responses, comparable to those seen with 5-HT drug challenge. Neuroendocrine testing was performed in the morning after an overnight fast. Plasma PRL