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Utility of cross‐matched platelet transfusions in patients with hypoproliferative thrombocytopenia: a systematic review

Multiply transfused hypoproliferative thrombocytopenic (HT) patients with alloimmune transfusion refractoriness require specially selected platelets (PLTs). Cross‐matching apheresis PLTs is a popular support option, avoiding requirements for large panels of typed donors for HLA‐based selection. We undertook a systematic review of the utility of various cross‐matching techniques on mortality reduction, prevention of hemorrhage, alloimmunization and refractoriness, and improvement in PLT utilization or count increments.