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The Prevalence of Thrombophilic Factors in Pregnant Women with Subjectively Oligohydraminos During the Gestational Age of 18- 27 Weeks

Objectives: To study the prevalence of Factor V Leiden (FVL), prothrombin gene mutation G20210A (F II) and methylenetetrahydrofolate reductase C677T (MTHFR) in pregnant women with subjectively diagnosed oligohydraminos during the gestational age from 18-27 weeks. 
 
Methods: A case-control study was conducted at the Jordan University Hospital and Farah Hospital Amman, Jordan during the period of 2006-2009. 100 pregnant women with oligohydraminos have been compared to 96 normal healthy childbearing age women. All subjects were investigated for the 3 genetically related thrombophilic factors. 
 
Results: Prothrombin gene mutation G20210A (F II) in pregnant women with oligohydraminos was higher 7.0% Vs 0% in the control group with a P-value of 0.008. Factor V Leiden (FVL) was also higher among pregnant women with subjectively oligohydraminos, 23.0% Vs 13.5% among the control group, but it did not reach statistical significance, P-value was 0.087. Methylenetetrahydrofolate Reductase C677T (MTHFR) was 52% among the pregnant women with subjectively oligohydraminos versus 55.2 % in the control group; P-value was 0.653 as shown in Table (2). 
 
Conclusions: As compared to the control group, Factor II G20210A was significantly higher among the pregnant women with subjectively oligohydraminos while FVL was also higher among this group, but it did not reach statistical significance. MTHFR was not higher among this group of pregnant women