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Ulcerative colitis associated with primary colorectal lymphoma in Taiwan: A tertiary center study

Ulcerative colitis (UC), an inflammatory bowel disease, increases the incidence of colon adenocarcinoma but is rarely complicated by primary colorectal lymphoma (PCL). This study evaluated diagnostic tools and the clinical symptoms, lymphoma type, and outcome of patients with UC who developed PCL. We retrospectively reviewed patient medical records from 1998 to 2018 at a single tertiary center. Three patients were identified; the studied period from UC diagnosis to lymphoma development ranged from 1 year 7 months to 7 years. Patients were aged 40 to 70 years. All patients were men and presented with bloody diarrhea. Two (66.7%) were diagnosed as having diffuse large B‐cell lymphoma through colonoscopic biopsy. Tumor location differed among all patients. Only one patient survived. PCL is rare in patients with UC and can be diagnosed through colonoscopic biopsy or surgical intervention. However, the clinical outcomes of these patients are poor.