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Mechanisms of Action of Nimesulide: Current Understanding

Objective of the Review: To discuss the current understanding of the mechanisms of action of nimesulide and describe the results of studies of this drug, particularly the pharmacokinetics of nimesulide with improved disintegration parameters, which significantly contribute to its therapeutic effect, and new studies of COX-independent effects of this medication. Key Points: The high bioavailability of nimesulide, effective pain relief, and a marked anti-inflammatory effect should be viewed as its advantages. The rapid onset of Nise’s analgesic action is explained by its 3D-effect, which is related to a high rate of tablet disintegration. The rapid and prolonged pain relief and anti-inflammatory effect provided by nimesulide are due to a wide range of effects not related to cyclooxygenase-2 inhibition. Conclusion: These properties of nimesulide make it the analgesic and anti-inflammatory medication of choice in clinical practice.