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[The interaction of macrophages and hematopoietic stem cells of mice in vitro and in vivo].

In the previous in vivo experiments it was shown that macrophages could modify the direction of haematopoietic stem cell (CFU-S) differentiation from erythroid to myeloid one, when injected simultaneously to lethally irradiated mice. Stable absorption of 50% CFU-S on the macrophage monolayer was documented in in vitro experiments, when it was incubated for 1 hour together with bone marrow cells. After administration to syngeneic recipients the CFU-S adsorbed by macrophages formed myeloid spleen colonies mainly. The nonadsorbed part of CFU-S underwent similar changes in the direction of differentiation, but only after a longer (2.5 hour) coincubation. The involvement of monokines in the control of the early differentiation of haematopoietic stem cells is suggested.