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Insulin‐like growth factor I receptor gene expression during postnatal development of rabbit kidney

Insulin‐like growth factor‐I (IGF‐I) is a peptide growth factor whose biological effects are mediated through a specific receptor (IGF‐IR). IGF‐I and IGF‐IR are detected in both fetal and adult kidneys and have both metabolic and growth effects. IGF‐IR expression during postnatal kidney development is not well defined and the biological role of this receptor during the postnatal stage is not clearly established. The purpose of the present study was to analyze IGF‐IR gene expression during the postnatal development of rabbit kidney to achieve a better understanding of the correlation between growth and differentiation of kidney tissues and IGF‐IR expression.