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Structure–Mechanics and Compressibility Profile Study of Flufenamic Acid:Nicotinamide Cocrystal

A contribution of crystal structure, mechanical moduli, and macroscopic compression properties of flufenamic acid (FFA) and its cocrystal with nicotinamide (NIC) was evaluated to predict their compaction performance. The FFA:NIC cocrystal formation was confirmed using differential scanning calorimetry, powder X-ray diffraction, and Fourier transform infrared. FFA:NIC compaction performance was compared with its coformers. Attachment energies (Eatt) with lowest absolute energy slip planes were calculated from reported crystal structures. Powder Brillouin light scattering was used to measure the mechanical moduli, while macroscopic compression performance was evaluated with “in-die” Heckel and compression energy descriptors. The absolute Eatt were found in the following ascending order: NIC < FFA:NIC < FFA. These materials can be arranged with their increased stiffness as FFA < FFA:NIC < NIC based on their elastic moduli. A relatively soft and elastic FFA showed highest compressibility but poor tabletabilit...