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The Impact of ETB Receptors on the Axon Reflex During Local Heating in Healthy Young Women

Endothelin‐1 (ET‐1) is a vasoconstrictor that acts on the vasculature through ETA and ETB receptors. Both ETA and ETB receptors are located in the skin and are involved in regulating skin blood flow. ETB receptors are also located on axon terminals on c‐type nociceptor fibers. Rapid local heating stimulates the axon reflex which has been established as a mediator of the initial vasodilation response. Although ETA receptors have been shown to augment the axon reflex resulting in a vasodilation, less is known about the role of the ETB receptors on the axon reflex.