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Treatment of polyglandular autoimmune syndrome with cyclosporin-A.

The case history of a 30-year-old female patient is reported. Following an unknown viral infection that had occurred four years earlier, insulin-dependent diabetes mellitus vitiligo, Addison's disease, amenorrhoea, hyperthyreosis and, finally, severe pancytopenia with dominant thrombocytopenia developed. On the basis of clinical aspects and laboratory findings, an infrequent polyglandular autoimmune syndrome (type II) was verified. Substituent therapy and steroid stoss therapy also was introduced, without any sign of improvement. For the lack of therapeutic effect and owing to serious thrombocytopenic bleeding, treatment with Cyclosporin-A was indicated, which produced total remission of the illness. Nowadays the patient being on follow-up, has no sign of disease activity.