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[Efficiency of M-22 human fibroblast culture as a tissue engineering factor in plastic repair of mandibular bone defects].

The results of inoculation of human fibroblast (strain M-22) and rabbit fibroblast cultures in standard bone defects were studied in 4 groups of rabbits 3 days to 3 months after inoculation of the cultures together with osteoplastic material (collapol KP-2). In the control groups the defects healed under a blood clot (group 1) or were filled with KP-2 (group 2). Histomorphological analysis of tissue showed that inoculation of M-22 cell culture into bone defects notably activated reparative osteogenesis in osseous wounds and stimulated healing, which was more rapid than in other groups. Inoculation of rabbit fibroblast culture in bone defects slightly inhibited the healing of bone wounds.