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T‐Antigen does not induce cell mediated immunity in patients with breast cancer

A total of 80 subjects with benign and malignant breast disease and healthy controls were studied for reactivity to T‐antigen, MN‐antigens and phytohemagglutinin (PHA) using the lymphocyte blastogenesis assay. No differences were detected between controls and patients with benign or malignant breast disease in reactivity to T‐ and MN‐antigens. Moreover, there was no differential response to T‐ and MN‐antigens among patients with breast cancer. PHA reactivity, although similar between groups as a whole, was diminished in patients with advanced carcinoma. These findings indicate that T‐antigen fails to induce cell mediated immunity in patients with breast cancer.