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Articles of Significant Interest Selected from This Issue by the Editors

Pulsatile hormone synthesis and secretion are critical for physiological processes, with disruption of episodic hormone release often associated with clinical disorders. Oscillatory follicle-stimulating hormone (FSH) and luteinizing hormone secretion is under the control of pulsatile gonadotropin-releasing hormone (GnRH), with FSH transcription preferentially stimulated at low rather than high GnRH pulse frequencies. Ciccone et al. (p. 1028–1040) have elucidated a mechanism by which these differential effects are orchestrated by two bZip family members, CREB and ICER. High GnRH pulse frequencies preferentially induce the transcriptional repressor ICER, which antagonizes CREB-mediated FSH stimulation to attenuate FSH expression. Our findings highlight ICER as a major integrative player in the maintenance of biological rhythms.