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Simultaneous administration of diphtheria/tetanus/pertussis/polio vaccine and hepatitis B vaccine in a simplified immunization programme.

In most developing countries hepatitis B virus is endemic and prevention has to be carried out early in life and on a mass scale. In these regions, simultaneous administration of multiple antigens is normal practice. We have therefore, investigated the interaction of hepatitis B vaccine with DTP-Polio vaccine. Studies include the immune response post one and two injections to diphtheria and tetanus toxoid, pertussis and hepatitis B surface antigen. The vaccines were given simultaneously or not at a 6 months interval. The immune response to HBsAg vaccine and DTP-Polio vaccine injected simultaneously was equal to the immune response observed after administration of vaccines alone. Moreover, no adverse reactions were noted. This trial also demonstrated that immunization with two doses of DTP-Polio vaccine, containing 30 Lf of diphtheria and tetanus toxoids, at a 6 months interval is sufficient to obtain a very good immune response.