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Effects of combined aerobic-strength training and yoga on quality of life and related parameters in women with pituitary adenoma after surgery: a randomized cross-over study.

OBJECTIVE
The pituitary gland is responsible for hormonal balance in the body, and disruption of hormonal balance in patients with pituitary adenoma (PA) indirectly affects quality of life. This study aimed to examine the effects of yoga and combined aerobic and strength training (A+ST) on quality of life and related parameters such as sleep, fatigue, emotional state, sexual function, and cognitive status in women with PA.


DESIGN
Ten women with PA were included in this randomized crossover study. Group 1 (n=5, mean age 52±13.5 years) received A+ST for the first 6 weeks, a 2-week washout period, and yoga for the second 6 weeks. Group 2 (n=5, mean age 41.8±14 years) received the yoga program first, followed by the A+ST program METHODS: Participants were assessed using the following tools before and after each exercise intervention: Functional Assessment of Cancer Therapy-Brain (FACT-Br), Pittsburg Sleep Quality Index (PSQI), Fatigue Severity Scale (FSS), Female Sexual Function Index (FSFI), Hospital Anxiety And Depression Scale (HADS), and Montreal Cognitive Assessment Scale (MOCA).


RESULTS
FACT-Br scores were higher after the yoga program, HADS anxiety score was lower after the A+ST program, and MOCA scores increased after both exercise programs (p<0.05). FSS score decreased after both exercise programs, but not significantly.


CONCLUSION
A+ST and yoga have positive effects on quality of life in PA . We recommend yoga and A+ST as a supportive therapy in this population that may face comorbidities after surgical and medical treatment. Our results indicate these patients may benefit from physiotherapist-guided exercise programs.