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Preliminary Reports on Plasma Prolactin and TSH Responses to Domperidone and TRH Administration in Patients Affected by Simple Thyroid Goiter Associated with Benign Breast Disease

Our investigation was carried out in 23 subjects aged 21-32 years (except for two subjects aged 16 and 18 years, respectively): Thirteen patients were affected by benign breast disease associated with simple goiter (group A) and 10 patients had isolated benign mastopathy (group B). Twelve age-matched healthy females were our controls. All patients had normal body weight and regular menses (except for 5 patients with slight oligomenorrhea) and they were untreated for at least 6 months. Clinical criteria and investigation by echography and mammography documented benign breast disease in all patients (groups A and B) (TABLE 1). The PRL and TSH patterns of responses