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The in vitro and in vivo Antibacterial Activity of Cefuroxime

Cefuroxime is a new cephalosporin antibiotic developed in 1975. The compound is characterized by high antibacterial activity against organisms resistant to the established cephalosporins, because it is stable to most of the ,-lactamases produced by Gram negative bacteria. This paper summarizes the results obtained from studies on cefuroxime such as in vitro antibacterial activity, protecting effect on experimental mouse infection and stability to ,Blactamase in comparison with other cephalosporins.