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Clinical studies of the combined action of ultraviolet and laser (662 nm) radiation with methylene blue for local therapy of defects of oral mucosa in chronic recurrent aphthous stomatitis

The work is devoted to the determination of the antibacterial activity of methylene blue under the action of ultraviolet radiation, laser radiation (660 nm), as well as their combined effect on standard strains of the bacteria Candida albicans, Staphylococcus aureus FDA 209P and Lactobacillus in vitro. When exposed to all the tested strains, a tendency was revealed with the most pronounced inhibitory effect with the combined action of laser and ultraviolet radiation together with the MB solution. Clinical studies of the in vivo use of methylene blue with the combined effect of ultraviolet and laser radiation (660 nm) in the treatment of chronic recurrent aphthous stomatitis in humans have also been conducted.