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Immediate and short‐term effects of pulmonary artery banding on left ventricular performance in foetal sheep

Aim: To evaluate foetal left ventricular performance when its preload was increased by banding the pulmonary artery, a study design where a simultaneous change in left ventricular afterload is unlikely. Methods: Nine ovine foetuses were studied with real‐time images and Doppler echocardiography before, 3–4 and 6–8 d after surgery. Seven of these foetuses were also studied during the surgical intervention, immediately before and within 2 min after banding. Results: The immediate effects of a 90‐95% reduction of the pulmonary artery cross‐sectional area were: a 53 ±; 20% (mean ±; SD) decrease and a 38 ±; 10% increase of right (RvQ) and left ventricular output (LvQ), respectively. Comparing measurements before and 3–4 d after operation, there was a 64 ±; 16% decrease of RvQ and a 64 ±; 25% increase of LvQ. The increase in LvQ was due to an increase in both heart rate (19 ±; 10%) and stroke volume (38 ±; 18%). After an additional 3–4 postoperative days, heart rate remained increased to the same extent, but there was a more pronounced increase of LvQ (93 ±; 19%) and stroke volume (59 ±; 22%).