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TRANSCRIPTIONAL REGULATION OF THE METHIONINE ADENOSYLTRANSFERASE 2A GENE DURING HEPATIC STELLATE CELL QUIESCENCE AND ACTIVATION

Methionine adenosyltransferases (MAT) catalyze the formation of the methyl donor, S‐adenosylmethionine (SAMe). The MAT2A gene encoding the catalytic subunit α2, is induced in de‐differentiated liver particularly in activated hepatic stellate cells (HSCs). MAT2A silencing reduces HSC activation. Our aim is to understand how MAT2A is regulated during HSC quiescence and activation.