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Third International Conference on Familial Mediterranean Fever and Other Hereditary Inflammatory Disorders.

This meeting was held in Montpellier, France on 23±27 September 2002 and was organized by Isabelle Touitou of Montpellier University. The opening ceremony took place at the Faculty of Medicine of Montpellier University, one of the oldest medical schools in Europe. Altogether, 190 physicians participated in the meeting, during which 180 abstracts were presented. The spectrum of the paper presentations encompassed all known episodic febrile auto-inflammatory disorders, including FMF (familial Mediterranean fever), HIDS (hyper-immunoglobulin D periodic fever syndrome), TRAPS (tumor necrosis factor receptor-associated periodic fever syndrome), CINCA (chronic infantile neurologic and articular syndrome), FCAS (familial cold auto-inflammatory syndrome), and MWS (Muckle-Wells syndrome). Due to space limitations and the absence of most disease entities other than FMF in Israel, we will focus only on presentations related to FMF. Familial Mediterranean fever is an autosomal recessive disorder that affects mostly Sephardic Jews, Armenians, Turks and Arabs. The disease presents as short febrile attacks (24±72 hours), peritonitis, pleuritis, arthritis, and erysipelas-like erythema. Amyloidosis occurs in untreated cases. Colchicine, 1±2 mg daily, ameliorates or decreases the frequency of the febrile attacks and prevents amyloidosis. At this meeting, M. Pras (Israel) estimated that the number of FMF patients in the world today is close to 120,000.