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A novel key driver gene of Alzheimer’s disease impacts AD‐related cognitive deficit, pathology and neuro‐inflammation in sex‐ and APOE‐specific manners

Alzheimer’s Disease (AD) has complex etiologies and the impact of sex on AD varies over the course of disease development. Literature provides some evidence of sex‐specific contributions to AD. However, molecular mechanisms of sex biased differences in AD remain elusive. Multi‐omics data in tandem with systems biology approaches offer a new avenue to not only dissect sex‐stratified molecular mechanisms of AD but also develop sex‐specific diagnostic and therapeutic strategies for AD.