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Enantioselective hydrogenation of isoquinolines.

Asymmetric hydrogenation of (hetero)arenes is one of the most straightforward ways to synthesize enantiomerically pure, saturated or partially saturated cyclic molecules. Recent progress has significantly expanded the substrate scope of this reaction. Whereas a number of highly efficient catalytic systems have been found for the asymmetric hydrogenation of quinolines, structurally related isoquinolines and pyridines are still regarded as challenging substrates for asymmetric hydrogenation (Scheme 1). The difficulty is presumably due