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Assay of Orphenadrine Citrate in Pharmaceuticals via Extraction-Spectrophotometric Method

An extraction-spectrophotometric technique has been applied and approved for the estimation of orphenadrine citrate in the presence of paracetamol in a binary synthetic mixture and in combined drugs. The procedure is built on the formation of a soluble red colour orphenadrine citrate – eriochrom black T (EBT) ion pair complex at pH 1.40, while the paractamol not paired. The produced red colour ionpair complex was extracted with chloroform and showed maximum absorption at 509 nm. For quantitative evaluation Beer’s law applied to plot the absorbance against concentration, the relation was a linear in the concentration range of 0.106.00 μg/ mL with the molar absorptivity 4.4025 x10 4 L / mol. cm. The limit of detection and limit quantification were 0.024 μg/ mL, and 0.100 μg/ mL respectively. The intra-assay precision evaluated in terms of % relative standard deviation (RSD) (< 2%). And accuracy was validated with % recovery (98.8102.5%). The results showed that orphenadrine citrate could be determined successfully in the combined tablet without interference by paracetamol and other common co-formulated substance.