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Cystic Fibrosis Oral Presentations

Introduction: Studies suggest that 10% of children with an ARI have persistent cough at day 21. There are no studies in Indigenous children who have a high risk of chronic lung disease. We aimed to identify the incidence and outcomes of ARI with cough as a symptom in urban Indigenous children. Methods:This is a prospective study of Indigenous children aged<5 years registered with a primary health service. Children are followed for a period of 12 months via monthly contacts. Children who develop cough as a symptom at any time are followed weekly for 4 weeks to ascertain cough outcomes. Results: To date, 162 children are enrolled, totalling 1065 child-months of observation. Two-hundred ARI episodes with cough have been reported (29.6 episodes/100 child-months at risk). Thirty-four ARIs (17%) have progressed to persistent cough at day 28 in 24 children. Of these, 15 children had 1 episode, 5 had 2, 4 had 3 and 1 had 4 during the follow-up period. The majority of children with persistent cough were diagnosed (by a respiratory physician) with protracted bacterial bronchitis and/or bronchiectasis. Conclusions:The proportion of children developing persistent cough postARI is higher than that currently reported (10%) with the majority suggesting protracted bacterial infection. GrantSupport:AQUTAPAaward, aQCMRIProgramGrant, UQFoundation Research Excellence Award, a QUT Indigenous Health Research StartUpGrant and the NHMRCCRE for LungHealth in Aboriginal and TorresStrait Islander Children. Declaration of Interest: None to Declare