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Lethal Perianal Buschke-Löwenstein Tumor in a Female Patient with AIDS

Giant condyloma acuminatum or Buschke-Löwenstein tumor (BLT) is a proliferative, locally invasive, rapidly growing, carcinomalike tumor of the anogenital region, with no metastatic potential and with histology similar to ordinary condyloma acuminatum. We present an HIV-seropositive woman with a perianal giant condyloma acuminatum which evolved into a squamous cell carcinoma. A 39-year-old woman came to our Department in June 1999 because of a painful, perianal ulcer of 4 months’ evolution. The ulcer was indurated with exophytic margins 2 ! 3 cm in diameter (fig. 1). She was an ex-endovenous drug abuser and was diagnosed as HIVseropositive in 1987. Since 1992, she had been treated intermittently Fig. 1. Clinical aspect of the lesion.