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Effects of an Acute High Fat Load on Peripheral Blood Mononuclear Cell Response among Women

The immune system and other cellular defense systems (i.e. metabolism) are interlinked and can respond to environmental stimuli. Inflammation, due to the over expression of pro‐inflammatory cytokines being released from peripheral blood mononuclear cells (PBMCs), is associated with a wide variety of disease states including cardiovascular and metabolic disease. Previous studies have indicated that PBMCs can respond to dietary stimuli, such as a high fat diet, which modulates the up‐regulation of pro‐inflammatory cell signaling. African American (AA) women compared to Caucasian (CA), have elevated pro‐inflammatory profiles which have been associated with an increased prevalence of metabolic disease. However, no study has investigated the influence ethnicity on PBMC gene expression in response to an acute dietary stimulus. Therefore, the purpose of this study is to investigate the impact that a typical, Western, high‐fat meal has on the expression of inflammatory genes from PBMCs isolated from AA and CA women.