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Cardiovascular and autonomic modulation in trained rats: effects of iNOS inhibition and oxidative balance in the rostroventrolateral medulla

We proposed to investigate the participation of the inducible nitric oxide synthase (iNOS) on glutamatergic neurotransmission and the oxidative profile in the rostral ventrolateral medulla (RVLM) in trained rats. Wistar rats were submitted to physical training (T) protocol or sedentary (S) for 4 weeks. After the last swimming session, the animals were submitted to guide cannulae implantation directed to RVLM. After 3 days of surgical recovery, femoral artery and vein catheterization were performed for direct recording of mean arterial pressure (MAP) and heart rate (HR). The acquired cardiovascular data underwent spectral analysis (Cardio Series®).