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Morphological Spot Segmentation for Gene Microarray Images

DNA microarray technology is one of the most powerful techniques used in modern biology and is extensively used for identification of sequence (gene/gene mutation) and determination of gene expression. A typical microarray image consists of a few hundred to several thousand spots and the extent of hybridization of these spots determines the level of gene expression (abundance) in the sample. A major issue in microarray image analysis is to accurately quantify spot shapes and intensities. In this paper we address this issue by performing accurate spot segmentation of a microarray image, using morphological image analysis techniques. This allows for estimation of the shape of the segmented spots using B-Splines or other parametric shape model.