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[Speed and intensity of the immune response to the administration of inactivated influenza vaccine in relation to neuraminidase activity].

A comparative study of the rate of appearance of specific virus antigen in immune competent organs of mice immunized with inactivated influenza vaccine with active neuraminidase or a vaccine devoid of the neuraminidase activity was carried out by means of the immunofluorescence test and the serological tests. A considerable delay in the time (by 16--18 hours) of detection of virus antigen in cells of lymph nodes of mice as well as later (1--2 days) and less intensive (2--4-fold) production of specific virus antibody was demonstrated after immunization of mice with the vaccine without the active enzyme.