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Successful thymus graft for T-cell deficiency in a 6-year-old boy.

these lymphoblasts with neuraminidase (Chapel, 1973; Mehrishi and Zeiller, 1974) did not increase the number of cells with markers and failed to show masked determinants. It is noteworthy that four out of the five patients with detectable Ig on the surface of their lymphoblasts were investigated at presentation before treatment. Further studies are planned to investigate if these lymphoblasts with surface Ig persist during the course of the disease. The findings in one patient (case 11) suggest that they do. Apart from this observation there was no correlation between the presence or absence of markers with the prognostic assessment at diagnosis, based on leucocyte count, percentage blasts, and presence or absence of mediastinal enlargement on chest x-ray picture. Nevertheless, important information can be obtained by characterizing surface markers on A.L.L. lymphoblasts. Such an approach may be clinically important in the early classification of cases of A.L.L. since there is some evidence that cases of Tcell origin have an exceptionally poor prognosis (Borella and Sen, 1973; Catovsky et al., 1974 b). The important observation that some A.L.L. lymphoblasts express B-cell markers, together with other recent findings (Haegert et al., 1974 b), suggest that A.L.L. is a disease of heterogeneous origin divisible into at least four groups-those without surface markers, those with Tor B-cell markers, and those cases expressing combined Tand Bcell determinants (Haegert et al., 1974 b).