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Is Migraine Really Comorbid with Systemic Lupus Erythematosus?

There is a growing interest in the literature scanning the association of systemic lupus erythematosus (SLE) with headache. In the American College of Rheumatology (ACR) nomenclature and a case definition for neuropsychiatric systemic lupus erythematosus (SLE) headache is considered as a part of the clinical spectrum of SLE (1). This reflects the common opinion among rheumatologists that SLE is often comordid with headache in particular migraine. Numerous articles reporting high headache and migraine prevalence in SLE patients appearing since the middle 1970s have contributed to this belief.