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[Stimulation of DNA synthesis in guinea pig spleen lymphocytes by staphylococcal peptidoglycan].

The mode of action of peptidoglycan on DNA synthesis in spleen lymphocytes of intact guinea-pigs was studied. It was found that peptidoglycan isolated from Staphylococcus aureus 2287 is mainly mitogenic for B lymphocytes that have IgG receptors on their surface. In contrast to lipopolysaccharide from Salmonella typhimurium, it seems that peptidoglycan is also mitogenic for less differentiated B cells.