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Cocaine Exposure During Pregnancy: Improving Assessment With Radioimmunoassay of Maternal Hair

Objective: To compare radioimmunoassay of postpartum maternal hair samples with a structured maternal interview for the detection of cocaine use during pregnancy. Methods: Radioimmunoassay of hair samples obtained postpartum was compared with self‐report of cocaine use obtained by confidential, structured interviews of 405 postpartum women. Results: Cocaine or benzoylecgonine was detected in the hair samples of 129 of the 148 women (87%) who reported using cocaine at least once during pregnancy. Thirty‐six of 257 women (14%) who reported that they had used no cocaine during pregnancy had positive hair tests. Positive hair assay with negative self‐report was significantly more common among women who were unmarried (P = .001), African‐American (P < .001), and multiparous (P = .035). Conclusions: Hair analysis is a valuable complement to maternal self‐report by interview. The methods used together provide a useful clinical and research technique yielding a comprehensive estimate of gestational cocaine exposure. Either method alone may result in misclassification of gestational cocaine exposure. (Obstet Gynecol 1994;83:524‐31)