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Plasma Soluble Cytokine Receptor Levels are Elevated during Heat Stroke Recovery in Mice

Cytokines are implicated as mediators of heat stroke (HS) morbidity/mortality. As shown previously, mice show hypothermia and fever during 24h of HS recovery, which correlate with high plasma IL‐1β and IL‐6 levels. This study examined plasma cytokine soluble receptor (SR) levels (sgp130, sIL‐1RI, sIL‐1RII, sIL‐4R, sIL‐6R, sTNFRI, sTNFRII; Luminex FlowMetrix(™)) in HS mice at baseline (To), HS collapse (Tc,Max=42.7°C), hypothermia depth (HD) and fever (24h). Sgp130 was not elevated at any time. sTNFRI was the only receptor elevated at Tc,Max and HD, with recovery at 24h. sTNFRII was elevated at HD only. sIL‐1RI and II were both elevated at HD; sIL‐1RI levels increased through 24h, whereas sIL‐1RII returned to baseline at 24h. sIL‐4R was elevated at 24h only, whereas the sIL‐6R showed elevations at Tc,Max and 24h, with a robust increase at HD. These results show the dynamic nature of SR responses in HS. Despite an inability to detect increased plasma IL‐4 and TNF levels in HS mice, SRs for these cytokines changed through 24h of recovery. SRs have agonist/antagonist actions, such that the role of cytokines in the HS syndrome remains poorly understood. Author views not official US Army or DoD policy.