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Cell death throes.

Living cells come equipped with a highly efficient death machinery that is readily activated when they reach their duly allotted life span or are deemed to be ineffectual, redundant, or damaged. The existence of a genetic death program was first inferred from the ordered morphologic changes revealed by electron micrographs of dying cells from organisms as diverse as amphibians and humans (1). The cell’s death throes are evidenced by compaction of the chromatin, which collapses against the nuclear envelope. The cell then shrinks, undergoing vigorous membrane blebbing—a dance of death—before finally breaking up into multiple membrane-enclosed vesicles (apoptotic bodies) that are engulfed by neighboring cells. Death is fast, 30–60 min, and clean—there is no leakage of intracellular contents, and inflammatory responses therefore are avoided.