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Chemosensitivity spectrum of a human pleural mesothelioma xenograft grown in athymic rats.

A human pleural mesothelioma tumour line (AKG) serially transplantable as a subcutaneously growing xenograft in athymic rats was evaluated for chemosensitivity to six antitumour drugs. Drug effects were assessed as the reduction of the area under the tumour volume curve (1-AUC) and as specific growth delay (SGD), resulting from the maximum tolerable dose (MTD) intraperitoneally in athymic rats. SGD greater than 2 or (1-AUC) greater than 0.85 were used as criteria of an active drug at the MTD. Etoposide (40 mg/kg), vincristine (0.9 mg/kg) and vindesine (0.8 mg/kg) were found to be inactive. Cisplatin (CDDP; 8 mg/kg) and carmustine (BCNU; 40 mg/kg) were found to be active resulting in (1-AUC)s of 1.04 and 0.88, respectively. Although mitomycin C (MC) at the MTD of 1.8 mg/kg resulted in a (1-AUC) of only 0.81, the SGD at a dose of 1.5 mg/kg was greater than 2 and therefore the drug was regarded as active. Furthermore, a combination of CDDP 3 mg/kg and MC 1.25 mg/kg was found to be active resulting in (1-AUC) = 0.90 and SGD = 4.70. The combination of CDDP and MC seems to be a promising regime warranting further studies.