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EFFECTS OF NG‐NITRO‐l‐ARGININE ON PRESSURE NATRIURESIS IN ANAESTHETIZED RABBITS

1. We tested the effects of blockade of nitric oxide synthesis on renal function under conditions of controlled renal artery pressure. Our hypothesis was that endogenous nitric oxide plays a role in the natriuresis that accompanies increased renal perfusion pressure. We used a novel technique which employed an extracorporeal circuit to produce step changes over a wide range of renal artery pressures in pentobarbitone‐anaesthetized rabbits.