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Are women suffering from COPD more sensitive to tobacco and its ingredients

Aim: To determine the possible difference in disease severity between men and women suffering from chronic obstructive lung disease (COPD) attributed to smoking. Sub- jects and methods: The study comprised a total of 250 subjects suffering from COPD: 82 (32,8 %) women and 168 (67,2 %) men with the average age of 68.2 years. Subjects were first divided into two gender-based groups. Each of the latter groups was subsequently subdivid- ed into the following subgroups: non-smokers, ex-smokers and active smokers. The study group comprised of women was dominated by non-smokers (N = 35; i.e. 42 %), while that comprised of men was dominated by smokers (N = 58; i.e. 34.5 %). In line with the GOLD cri- teria observed back in 2010, subjects were divided into three groups (GOLD I, GOLD II i GOLD III) based on their disease severity. Results: Comparison of the length of smoking expressed in the number of cigarettes smoked per day divided by 20 (no of cigarettes in a single pack) and further multiplied by the number of years of active smoking (pack/year; p/y), made be- tween former and active smokers of both genders, shows inter-gender differences in disease severity. A lower total number of former and active female smokers having a lower p/y at- tains the same degree of the disease severity as men having a substantially higher p/y (p = 0.009). Conclusion: The results of this study suggest that female airways might be more sen- sitive to tobacco smoke and its ingredients as compared to those of men.