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PHARMACOLOGICAL ACTIVITY OF AQUEOUS EXTRACTS OF MULTICOMPONENT PRODUCTS OF NATURAL ORIGIN AND GELS BASED ON THEM

The purpose of this article was to study pharmacological activity of wax, propolis and oleoresin aqueous extracts and gels based on them obtained in the conditions of the laboratory. Minimum suppressive and minimum bactericidal concentrations of wax, propolis and oleoresin aqueous extracts are obtained by a two-fold dilution method and their combined action with chlorhexidine bigluconate by the “checkerboard method” were studied. Antimicrobial and local anti-inflammatory activity of gels based on them was also studied. It was found that wax and oleoresin aqueous extracts have a weak antimicrobial effect against gram-positive and gram-negative microorganisms. Gels based on propolis and wax have a weak antimicrobial effect in concentration of 5%, gels based on oleoresin have a weak antimicrobial activity in concentration of 1% and an average antimicrobial activity in concentration of 5%. Combinations of aqueous extracts with chlorhexidine bigluconate have neither synergetic nor additive effect, i.e. combination of substances has the same effect on microorganisms as the substances separately. High anti-inflammatory activity of gels based on an aqueous extract of propolis was established.