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Rapid, sensitive gas-chromatographic quantitation of methohexital in plasma of oral-surgery outpatients.

Induction, maintenance, and recovery during the course of IV anesthesia are dependent upon the amount of anesthetic within brain tissues after admin-istration, and this is a function ofthe amounts ofdrug in plasma. Thus, recovery times in patients undergoing IV anesthesia may be predictable by knowing the amount of drug in plasma. Methohexital is an ul-trashort acting barbiturate commonly used as an IV anesthetic in oral-surgery outpatients. Although the quantitative measurement of methohexital in body fluids by gas chromatography has been established, a rapid and sensitive assay for this drug in the plasma of outpatients undergoing oral-surgical procedures has yet to be reported.