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Recent advances in microcolumn liquid chromatography.

In 1981 an article in Analytical Chemistry described a relatively new direction in modern liquid chromatography (LC). Since that time, microcolumn LC, which was initiated during the late 1970s, has undergone extensive development. Whereas the main purpose of the 1981 article was to acquaint the analytical chemistry community with some unique features of miniaturized LC systems and their potential for various separations and measurements, this article provides a summary of the recent progress in microcolumn LC and, once again, points out new directions. Owing to the small number of laboratories engaged in microcolumn LC prior to 1981, the earlier article was comprehensive of the various developments of that time. The present article necessarily excludes this luxury, because the number of papers and presentations in this area has grown substantially.