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The role of p53 induced cellular senescence in age related disorders.

Protein p53 is described as guardian of the genome contributing for the suppression of tumorigenesis. p53 is also known to be the critical regulator of cellular senescence. It is activated by various genomic stresses including telomere attrition, excessive mitogenic sig- naling and genotoxic agents(eg. reactive oxygen species), and mediates cellular senescence. Senescent cells develop growth arrest, associated with altered gene profiles. These changes induce chronic inflammation and organ dysfunction, promoting pathologies in age related disorders. In this review, we delineate the role of p53 induced cellular senescence in age related disorders, such as obesity/diabetes and heart failure.