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Abnormal colonic motility in mice overexpressing human wild-type &agr;-synuclein

The presynaptic protein &agr;-synuclein (&agr;Syn) has been implicated in both familial and sporadic forms of Parkinson's disease. We examined whether human &agr;Syn-overexpressing mice under Thy1 promoter (Thy1-&agr;Syn) display alterations of colonic function. Basal fecal output was decreased in Thy1-&agr;Syn mice fed ad libitum. Fasted/refed Thy1-&agr;Syn mice had a slower distal colonic transit than the wild-type mice, as monitored by 2.2-fold increase in time to expel an intracolonic bead and 2.9-fold higher colonic fecal content. By contrast, Thy1-&agr;Syn mice had an increased fecal response to novelty stress and corticotropin releasing factor injected intraperipherally. These results indicate that Thy1-&agr;Syn mice display altered basal and stress-stimulated propulsive colonic motility and will be a useful model to study gut dysfunction associated with Parkinson's disease.