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Asenapine modulates mood‐related behaviors and 5‐HT1A/7 receptors‐mediated neurotransmission

Asenapine is a new atypical antipsychotic prescribed for the treatment of psychosis/bipolar disorders that presents higher affinity for serotonergic than dopaminergic receptors. The objective of this study was to investigate its antidepressant‐like and antimanic‐like properties on relevant animal models of depression and mania and to assess the acute and chronic effect of Asenapine on dorsal raphe nucleus (DRN) 5‐HT cell firing activity.