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Cold exposure and the metabolism of mice, men, and other wonderful creatures.

Laboratory rodents and cold-adapted animals in the wild use a significant amount of the energy derived from food intake for heat generation. Thermogenesis involving mitochondrial uncoupling in the brown adipose tissue differs quantitatively in mice, men, and cold-adapted animals, and could be an important ally to combat obesity, if humans were prepared to deviate slightly from thermoneutral living conditions to activate this pathway.