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A Live Human B‐Cell Activator Operating in Isolation of Other Cellular Influences

Using a reversed haemolytic plaque assay, we demonstrate that live but not inactivated Epstein‐Barr (EB) virus can induce human blood tymphocytes to polyclonal Ig (IgM and IgG) secretion in vitro. Unlike pokeweed mitogen this B‐cell‐activating effect takes place in relative absence of T cells. EB virus thus promises to be a tool for study of B cell function isolated from other cellular influences, although its mechanism of activation appears to be different from that of previously known B cell activators.