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The interaction between intracapillary and tissue forces in the overall regulation of interstitial fluid volume.

This article is an attempt to integrate recent work on the regulation of interstitial volume with past work from this laboratory and others. A simple mathematical approach indicates how extremely sensitive interstitial fluid pressure and lymph flow are to small changes in interstitial fluid volume and how these two tissue factors coupled with tissue protein washout interact to maintain the tissues in a nonedematous state.