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The effect of high nutrient on the growth performance, adipose deposition and gene expression of lipid metabolism in the neonatal intrauterine growth-retarded piglets

ABSTRACT Twelve pairs of intrauterine growth retardation (IUGR,1.84 ± 0.09 kg) and normal birth weight (NBW, 2.80 ± 0.16 kg) of Duroc × Landrace × Yorkshire piglets (7-day old) were randomly assigned to four treatments (six replicates per treatment) in a 2 × 2 factorial design. IUGR and NBW piglets were fed diets of either normal nutritional level (NN, 880 kcal/L, 50 g of protein/L) or high nutritional level (HN, 1320 kcal/L, 75 g protein/L)for 21 days. IUGR decreased the average daily dry matter intake (ADMI), the average daily growth (ADG) and leaf fat relative weight. Regardless of body weight, HN could increase the ADMI, ADG and intramuscular fat content, and enhance serum insulin, IGF-I and leptin concentrations, but decreased serum adiponectin concentrations in IUGR piglets. Furthermore, HN could increase the PGC-1α of liver and C/EBPα of longissimus expression in IUGR piglets. These results suggested that the IUGR piglets had lower growth performance and adipose deposition than NBW piglets. However, HN in diets could make up the defect of IUGR piglets in the uterus, and regulated the expression of lipid metabolism genes in some tissues of IUGR piglets.