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[Synthesis of N-alpha-(8-quinolinesulfonyl)-4-amidinophenylalanine amides as thrombin inhibitors].

The compounds mentioned in the title were prepared starting from 4-cyanophenylalanine by sulfonylation using 8-quinoline sulfonic acid chloride, formation of the 4-nitrophenylester, aminolysis of the latter and subsequent transformation of the cyano via the thiocarbamoyl and the thioimid acid ester into the amidine group. The antithrombin effect decreased by substituting the 1-naphthylsulfonyl by the 8-quinolinesulfonyl residue.