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Abstract 4615: Phenotypic subtypes successfully stratify prognosis of patient with colorectal cancer: A step towards precision medicine

Background: There has been enormous effort to develop a prognostic genomic classification of colorectal cancer (CRC). As a result, mismatch repair (MMR) status was established as a prognostic marker in addition to TNM-staging. Phenotypic subtypes were recently proposed that stratified patient survival based on assessing the immune infiltrate (KM grade), tumour growth (Ki67) and stromal infiltrate (TSP). However their clinical utility had not been compared to other proposed classification systems including consensus molecular subtypes (CMS) or current prognostic markers including MMR status. Methods: Three patient cohorts, a pilot cohort of 237 stage I-III CRC patients, a validation cohort of 879 stage I-III CRC patients, and the AMC-AJCCII-90 cohort with 81 stage II colon cancer patients were utilised to investigate associations between phenotypic subtypes, MMR status, CMS and patient survival. Results: In the pilot cohort, phenotypic subtype stratified cancer-specific survival (P Conclusions: Phenotypic subtype is a more effective prognostic classification than CMS and MMR status. Phenotypic subtype is clinically relevant to all patients irrespective of site and adjuvant treatment. Phenotypic subtypes should be incorporated alongside MMR status as a clinical aid for the prognosis of patients with CRC. Citation Format: Antonia Kathryn Roseweir, James H. Park, Sanne ten Hoorn, Arfon G. Powell, Campbell S. Roxburgh, Donald C. McMillan, Paul G. Horgan, Louis Vermeulen, Joanne Edwards. Phenotypic subtypes successfully stratify prognosis of patient with colorectal cancer: A step towards precision medicine [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4615.