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Association of FUT2 and ABO with Crohn's disease in Koreans

Fucosyltransferase 2 (FUT2) at 19q13 is a well‐established susceptibility locus for Crohn's disease (CD) in Caucasians. FUT2 encodes α‐1,2‐fucosyltransferase that regulates the secretion of the α‐1‐2‐N‐acetylgalactosaminyltransferase and α‐1‐3‐galactosyltransferase (ABO) antigens in both the gastrointestinal mucosa and secretory glands. Given that CD is thought to arise from dysregulated mucosal immune responses to the gut flora and both the ABO blood group and the FUT2 secretor status affect the composition of the gut microbiota, the goal of this study was to evaluate the associations of variants of FUT2 and ABO with CD in Koreans.