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Anti‐idiotypic IgM Antibodies to Anti‐HLA Class I Antibodies in Habitual Abortion

ABSTRACT: In order to investigate the role of the idiotypic network in miscarriages, sera from 28 habitually aborting women undergoing paternal leukocyte immunization were studied for the presence of HLA antibodies and related anti‐idiotypes. Sixty‐eight percent of sera from preimmunized patients which did not contain anti‐lymphocyte antibodies inhibited the activity of antibodies to the HLA class I antigens expressed by the spouse.