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Maternal high fat diet and offspring CNS gene expression

The goal of our research is to understand the molecular mechanisms that link maternal high fat diet consumption during pregnancy with altered CNS gene expression in the offspring. In our model, pregnant and lactating mouse dams are fed a high fat (HF) diet, and large for gestational age (LGA) offspring demonstrate significant dysfunction in the dopaminergic, and opioid systems. Prenatal diet can impact DNA methylation, and we have documented both global and gene‐specific methylation differences in LGA mice.