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Effect of Oxygen on the Induction of Tryptophan Hydroxylase by Adrenergic Agents in Organ Cultures of Rat Pineal Glands

Abstract: Rat pineal glands, cultured under 95% air and 5% CO2, lost 50% of their tryptophan hydroxylase activity within 5 h. This loss was accelerated by the addition of cycloheximide or puromycin to the medium. Activity was, however, largely maintained in 95% O2 and 5% CO2. Under these conditions, L‐noradrenaline (100 μ.M), L‐iso‐proterenol (10 μM), and dibutyryl cyclic AMP (1 mM) induced enzyme activity. They failed to do so when 95% air and 5% CO2 was used. Noradrenaline induced serotonin N‐acetyltransferase activity with either atmosphere.