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Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G‐protein activation in the 3D reconstructed epileptic rat brain

Purpose:  The endocannabinoid system is known to modulate seizure activity in several in vivo and in vitro models, and CB1‐receptor activation is anticonvulsant in the rat pilocarpine model of acquired epilepsy (AE). In these epileptic rats, a unique redistribution of the CB1 receptor occurs within the hippocampus; however, an anatomically inclusive analysis of the effect of status epilepticus (SE)–induced AE on CB1 receptors has not been thoroughly evaluated. Therefore, statistical parametric mapping (SPM), a whole‐brain unbiased approach, was used to study the long‐term effect of pilocarpine‐induced SE on CB1‐receptor binding and G‐protein activation in rats with AE.