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Acellular Dermal Matrix in Tissue Expander Breast Reconstruction Predicts Increased Infection and Seroma in a Multivariate Regression Model

INTRODUCTION: Acellular dermal matrix (ADM) is a popular adjunct to two-stage tissue expander/implant (TE/I) breast reconstruction following mastectomy. Touted benefits include the ability to rapidly expand the breast mound and improved aesthetic results. Recent comparative studies as well as our preliminary results have raised the possibility of higher complication rates associated with ADM use (1-4). However, existing knowledge is limited due to an inability to account for existing predisposing patient conditions. Our study assessed relative risks for complications in a large series of TE/I breast reconstructions using a robust multivariate regression model.