{'fraction_non_alphanumeric': 0.02574416733708769, 'fraction_numerical': 0.007240547063555913, 'mean_word_length': 5.098039215686274, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Inhibitory Effects of Bound Polyphenol from Foxtail Millet Bran on Colitis-Associated Carcinogenesis by the Restoration of Gut Microbiota in Mice Model.

Colorectal cancer (CRC) is a common malignant tumor occurring in the colon. It has been known that gut microbiota is a complex ecosystem and plays an important role in the pathogenesis of colorectal cancer. Our previous study showed that bound polyphenol of inner shell (BPIS) from foxtail millet bran exhibited significant anti-tumor activities in cancer cells and nude mice model. In the present study, the anti-cancer potential of BPIS is evaluated in the azoxymethane (AOM) and dextran sodium sulfate (DSS) induced mouse CRC model. Results showed that BPIS could decrease the number and volume of tumors, protect epithelial architecture from damage. Certain biomarkers associated with CRC formation, such as COX-2, EMR1, PCNA and caspase-3, were strongly changed by BPIS. Moreover, by 16S rRNA gene sequence analysis, it was found that BPIS could remodel the overall structure of the gut microbiota from tumor-bearing mice toward that of the normal counterparts, including 2 phyla and 8 genera, together with regulations on several genes that are responsible for 17 signaling pathways.