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Action spectra of topical psoralens: a re‐evaluation

The action spectra for producing minimal phototoxic erythema with topical 0 1% trimethyl psoralen (TMP) and 8‐mcthoxypsoralen (8‐MOP) were determined with a double monochromator in the range of 295–380 nm. Both psoralens induced photosensitivity in the range of 313–365 nm; TMP was 54% more effective than 8‐MOP. There was no difference in the dose needed to produce minimal UV erythema or phototoxic erythema with 8‐MOP and TMP at 295 and 305 nm, but at 313 nm with 8‐MOP, photosensitivity was enhanced 3.5 times, and with TMP, sensitivity was enhanced 55 times. The peak sensitivity with 8‐MOP was at 330 nm and for TMP it was 335 nm. No photosensitivity occurred above 380 nm. Results suggest that TMP and 8‐MOP are significantly photoreactive at 320–335 nm. Commonly used UV‐A light sources show peak emission around 360 nm. If there is a relationship between development of erythema and therapeutic effectiveness then this raises the possibility of alternative UV light sources for phototherapy with psoralens.