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Bile duct basement membrane thickening in primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is characterized histologically by portal inflammation, bile duct injury and regeneration and concentric periductal fibrosis. Although seen commonly in our experience, the significance of histological thickening of the bile duct basement membrane on periodic acid Schiff (PAS)‐positive, diastase‐resistant (DPAS) staining has never been analysed formally. In this paper we provide an evidence‐based assessment of basement membrane thickening (BMT) reproducibility and diagnostic accuracy.