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Respiratory responses of humans exposed to an aerosol–gas pollutant mixture: Multivariate contrast of a complex atmosphere to clean air and sodium chloride aerosol controls

Data from a group of 20 subjects with normal baseline pulmonary function, who were exposed for 2 h to a test atmosphere containing a complex mixture of pollutants, have been contrasted with data from two other groups exposed to presumably non‐toxic control atmospheres. Group 1 was exposed to clean air, group 2 was exposed to clean air containing sodium chloride aerosol at 270 μg m−3, and group 3 was exposed to the complex atmosphere containing sodium chloride (332 μg m−3) and zinc ammonium sulfate (23 μg m−3) aerosols plus nitrogen dioxide (0.5 ppm) and sulfur dioxide (0.5 ppm). These atmospheres (ranked according to the presumed relative toxicities of the components; clean air=0, sodium chloride=1, complex mixture=2) were contrasted using multiple regression and partial correlation analyses. The effects of exposure to the complex gas‐aerosol mixture on forced expiratory performance were not significantly different from those observed in subjects exposed to clean air or to sodium chloride aerosol.