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PACAP Inhibits Oxidative Stress‐Induced Activation of MAP Kinase‐Dependent Apoptotic Pathway in Cultured Cardiomyocytes

Abstract:  The present article investigated the effect of pituitary adenylate cyclase‐activating polypeptide (PACAP) on oxidative stress‐induced apoptosis in neonatal rat cardiomyocytes. Our results show that PACAP decreased the ratio of apoptotic cells following H2O2 treatment. PACAP also diminished the activity of apoptosis signal‐regulating kinase. These effects of PACAP were counteracted by the PACAP antagonist PACAP6‐38. In summary, our results show that PACAP is able to attenuate oxidative stress‐induced cardiomyocyte apoptosis and suggest that its cardioprotective effect is mediated through inhibition of the MAP kinase‐dependent apoptotic pathway.