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The administration of Dioscorea batatas extract and fish oil inhibits the development of oxazolone‐induced atopic dermatitis‐like skin lesions in hairless mice

Atopic dermatitis (AD) is a chronically relapsing inflammatory disorder that is characterized by pruritic and eczematous skin lesions. In this study, we examined whether Dioscorea Batatas extract (DBE) and/or fish oil (FO) suppress the development of AD‐like skin lesions. SKH1 hairless mice were divided into eight experimental groups as follows: control, positive control, FO 0.09%, FO 0.18%, DBE 0.17%, DBE 0.33%, FO 0.18% + DBE 0.17% and FO 0.18% + DBE 0.33%. All animals except those in control groups were treated with OX for two weeks after the first experimental diet supply. Administration of FO and DBE inhibited the development of AD‐like skin lesions as exemplified by decreases in skin severity score, hypertrophy of the skin, infiltration of inflammatory cells in the epidermis and dermis. FO and DBE significantly reduced serum levels of both macrophage‐derived chemokine (MDC) and interleukin‐6 (IL‐6), and the mixture of FO and DBE markedly reduced IL‐6 concentration. In addition, FO and DBE mixture supplementation significantly decreased the mRNA expression of interleukin‐4 (IL‐4) in draining lymph nodes. These results suggest that FO and DBE effectively suppress the development of AD skin lesions, possibly by suppressing Th2 cell‐mediated immune responses.