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[Determination of hydrophobic pharmaceutical: tablet of reserpine compound by capillary zone electrophoresis].

Tablet reserpine compound is a kind of hydrophobic pharmaceutical that can not be separated by CZE with salt-water system. We solved this problem by adding organic component into the buffer. Thus a satisfactory separation of reserpine and hydrochlorothiazide was achieved by using a 24% (V/V) acetonitrile in the buffer solution of 10 mmol/L phosphate with a pH 9.0. The capillary column of 50 microns i.d. and 50 cm total length with effective length(the distance from the inlet to the detector) of 35 cm was used during all analytical procedure. The factors which influenced resolution such as the pH, acetonitrile content and phosphate concentration have been investigated. The CZE separation conditions of reserpine and hydrochlorothiazide using the standard mixture solution, are also showed. In the quantitative analysis, the reproducibility of CZE determination is illustrated. The regression coefficients of calibration graphs and the detection limits are given. The results of the study of recovery and quantitative results of these components using external standard method are given.