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Molecular Docking of Gnetin C and Transresveratrol of Melinjo Seeds (Gnetum Gnemon L.) Used as the Inhibitors of Breast Cancer Cells MCF-7

: Breast cancer is cancer caused by uncontrolled cell growth in breast tissue. In this research, molecular docking has been studied to predict the binding afﬁnity of Gnetin C dan trans-resveratrol as active compounds of melinjo seeds to inhibit breast cancer cells Michigan Cancer Foundation-7 (MCF-7). Molecular docking was performed by autodock-vina. The result indicated that Gnetin C and trans-resveratrol could bind the same amino acid as natural ligan of MCF-7 such as VAL 54B, VAL54B, TYR 55B, TYR 216B, TRP 227B, LEU 306B, LEU 306B, and LEU 306B. The binding afﬁnity of Gnetin C and transresveratrol was -6. and -7.9, respectively, while the natural ligan was -10.0. It means Gnetin C and trans-resveratrol can bind the protein acid of MCF-7, although the docking energy was lower than the natural ligan. Based on this research, Gnetin C and trans-resveratrol are potential anticancer and chemoprevention because they can inhibit some amino acids of cancer cells MCF-7.