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Physical activity opposes the age‐related increase in skeletal muscle and plasma endothelin‐1 levels and normalizes plasma endothelin‐1 levels in individuals with essential hypertension

Endothelin‐1 has potent constrictor and proliferative activity in vascular smooth muscle, and essential hypertension and aging are associated with increased endothelin‐1‐mediated vasoconstrictor tone. The aim of this study was to investigate the effect of physical activity, hypertension and age on endothelin‐1 levels in plasma and skeletal muscle and endothelin receptors in skeletal muscle in human subjects.