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Cerebral and muscle oxygen saturation measurement by a frequency-domain near-infrared spectroscopic technique

Absorption and reduced scattering coefficients at 715 and 825 nm as well as hemoglobin saturation and content of the forehead and the forearm were measured by a 110 MHz frequency-domain multisource instrument. The absolute data obtained by the frequency- domain spectrometer were compared with oxygenation changes measured by a continuous wave instrument during quadriceps ischemia and postural changes. These preliminary results indicate that portable frequency-domain instruments could be very helpful to investigate brain and muscle pathophysiology.