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Synergistic underpinning of global amyloid and cingulate neuroinflammation underlies tau propagation in Alzheimer’s disease

Understanding the underling pathophysiology of tau burden and its propagation through Braak stages is imperative in Alzheimer’s disease (AD) and its clinical trial strategy. This multimodal PET study aimed to reveal the Aβ ([18F]AZD4694) and activated microglia ([11C]PBR28) converges to potentiate the NFTs ([18F]MK6240) deposition in AD in Braak stages. We hypothesized that the NFTs deposition driven by Aβ and neuroinflammation leads to cognitive.