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Inhibition by Leukotriene Inhibitors, and Calcium and Platelet‐activating Factor Antagonists, of Acute Gastric and Intestinal Damage in Arthritic Rats and in Cholinomimetic‐treated Mice

The leukotrienes, platelet activating factor and intracellular calcium have been implicated in the development of gastro‐intestinal lesions induced by non‐steroidal anti‐inflammatory drugs (NSAIDs) but the relative significance of these inflammatory mediators in lesion formation has not been established in sensitive and specific models of gastro‐intestinal ulceration. In the present study the effects of drugs affecting 5‐lipoxygenase activity, the actions of platelet activating factor and intracellular calcium on the development of gastric and intestinal ulceration induced by NSAIDs were investigated in highly sensitive models of ulcerogenicity induced by treatment with either the cholinomimetic, acetyl‐β‐methyl choline chloride, in mice (gastric mucosal lesions) or adjuvant‐induced polyarthritis in rats (gastric and intestinal mucosal lesions) as well as in normal mice (intestinal mucosal lesions).