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Effect of oral contraceptives on antithrombin III measurement.

The effect of oral contraceptives on antithrombin 3 measurement is briefly discussed in response to an article by Peterson et al. They suggest that an inhibitor of antithrombin 3 might be responsible for the discrepancy between functional and immunologic assays. However alternative explanations are possible. The reduction in serum antithrombin 3 could be due to increased removal during specimen processing since the amount removed during clotting is not standarized and is probably dependent upon the concentration of other coagulation factors. It is possible that the immunologic method measured both free antithrombin and antithrombin-factor complexes. If so the immunologic method would over-estimate the "functional" antithrombin. Thus the discrepancy obtained by functional (serum) and immunologic methods may be due to technical problems rather than the appearance of an inhibitory substance. It is suggested that the results from a comparison of functional and immunologic levels on plasma antithrombin 3 would help clarify some of the effects found by Peterson et al.