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Pharmacologic Treatment of Adults with Trauma- and Stressor-Related Disorders

This chapter reviews evidence-based pharmacological treatments for posttraumatic stress disorder, acute stress disorder, and adjustment disorder in adults. Emphasis is given to treatments that have received the strongest recommendations in published practice guidelines, clinical trials, and meta-analyses. Mention is also made of pharmacological interventions introduced subsequent to changes in diagnostic definitions that occurred with the shift to the category trauma- and stress-related disorders in the Diagnostic and Statistical Manual of Mental Disorders (fifth edition). Medications covered in this chapter are across a broad range of classes and include serotonin specific reuptake inhibitors (SSRIs), antipsychotics, anticonvulsants, and benzodiazepines. The discussion addresses medications used as monotherapy and as medication augmentation.