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[Comparative study of tears protein composition in patients after photorefractive keratectomy and laser specialized keratomileusis].

Changes in the protein spectrum of the lacrimal fluid, resultant from refraction ocular surgery (photorefraction keratectomy, PRK, and laser specialized keratomileusis, LASIK) were evaluated. Lacrimal fluid was collected before operation and in various terms after it in 28 patients (48 eyes) subjected to PRK and in 34 patients (59 eyes) subjected to LASIK. Biochemical analysis of the lacrimal fluid was performed on a mass spectrometer. After PRK the greatest changes in the protein spectrum occurred immediately after the operation before reepithelialization. Changes after LASIK were negligible. Refraction laser operations cause changes in the protein composition of tears, LASIK being more physiological than PRK from viewpoint of intactness of the protein composition of tears.