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Hormonal Contraceptives and Migraine With Aura—Is There Still a Risk?

Unnecessary confusion still surrounds the use of combined hormonal contraceptives (CHCs) in the setting of migraine with aura (MwA). Clearing this confusion is a key issue for headache specialists, since most women with migraine have menstrual‐related migraine (MRM), and some CHCs can prevent this particularly severe migraine. Their use, however, is still restricted by current guidelines due to concerns of increased stroke risk – concerns that originated over half a century ago in the era of high dose contraceptives. Yet studies consistently show that stroke risk is not increased with today's very low dose CHCs containing 20‐25 µg ethinyl estradiol (EE), and continuous ultra low‐dose formulations (10‐15 µg EE) may even reduce aura frequency, thereby potentially decreasing stroke risk.