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272 HEART RATE RESPONSE DURING LOCOMOTOR ACTIVITY IS BETTER MAINTAINED IN CONGENIC RAT

Objectives, Background: The congenic rats (SHRSPwch1.0) were derived from stroke-prone SHR/Izm (SHRSP/Izm) and Wistar-Kyoto rat/Izm (WKY/Izm). We found that systolic arterial pressure (SAP) was an intermediate value between SHRSP/Izm and WKY/Izm and that the locomotor activity (ACT) was the greatest amongst these strains. To study the interrelationship amongst SAP, heart rate (HR) and ACT in SHRSPwch1.0, we evaluated the responses of SAP and HR during increased ACT in SHRSPwch1.0 and compared to those in SHRSP/Izm. Design and methods: We used ten male mature SHRSPwch1.0 and 10 age-sex matched SHRSP/Izm, and monitored SAP, HR and ACT using radio-telemetry. The responses of SAP and HR during increase ACT were calculated by (mean nighttime SAP-mean daytime SAP)/(mean nighttime ACT-mean daytime ACT) and that of HR by (mean nighttime HR-mean daytime HR)/(mean nighttime ACT-mean daytime ACT). Results: SAP in SHRSPwch1.0 was lower than in SHRSP/Izm (mean±SD, 194±9 vs. 229±15mmHg, P=0.0012). HR in SHRSPwch1.0 was slower than in SHRSP/Izm (310±9 vs. 381±45 beats/min, P=0.0110). ACT in SHRSPwch1.0 was higher than that in SHRSP/Izm (62±47vs. 26±27, median, 58 vs.18, IQR, 33 vs.18 counts/10 sec, all P<0.0010). SAP response during increased ACT in SHRSPwch1.0 did not differ from that in SHRSP/Izm. However HR response during increased ACT was greater in SHRSPwch1.0 than that in SHRSP/Izm (4.75±4.01 vs. 0.16±0.24 beats/counts/10 sec, P=0.00555). Conclusions: The HR response during increased ACT is greater in congenic rat than that in SHRSP. Therefore, the relationship between HR and ACT may better be maintained in congenic rat than that in SHRSP.