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[Results of multiple endocrine neoplasia type 1 in Japan from a multicenter database].

The results of 208 and 560 patients with multiple endocrine neoplasia type 1 (MEN1) in Japan were analyzed from a multicenter database. The most common primary tumors are hyperparathyroid, followed by gastoroenteropancreatic neuroendocrine tumors (GEPNET) and pituitary tumors. After these three types of tumor, many adrenocortical tumors and bronchial and thymic neuroendocrine tumors were reported. Most MEN-related deaths were due to metastasis and the recurrence of GEPNET or thymic neuroendocrine tumors. MEN1 is a disease in which many specialties are involved and it should be in managed by diagnostic treatment in recognition of the broad spectrum of tumors which may occur.