{'fraction_non_alphanumeric': 0.017059301380991064, 'fraction_numerical': 0.0016246953696181965, 'mean_word_length': 5.73224043715847, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Synthesis of Folate Conjugated Fluorescent Nanoparticle Probe and Its Application in Cervical Cancer Cell Imaging

Abstract Cervical cancer is the second most common cancer in women worldwide with 80% of cases arising in the developing world, following cancer of the breast. The mortality associated with cervical cancer can be reduced if this disease is detected in a timely fashion. In this study, a folate conjugated fluorescent nanoparticle (FCFN) probe was used to detect cervical cancer cells. Fluorescent nanoparticles (FNs), with excellent characteristics such as nontoxicity and photostability, were first synthesized with a simple, cost-effective, and environmentally friendly modified Stőber synthesis method and then successfully modified with folate. This kind of fluorescence probe based on FCFNs has been used to detect cervical cancer cells with fluorescence microscopy imaging technology. The experimental results demonstrate that the FCFNs can effectively recognize cervical cancer cells and exhibit good sensitivity and exceptional photostability; they would provide a novel way for the diagnosis and curative effect observation of cervical cancer cells and offer a new method in detecting folate receptors (FR).