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[Changes of thyroid hormone levels in the progression of coronary arteriosclerosis].

The study concerned changes in the levels of thyroid hormones (T3, T4) and their proportional relations in the serum of peripheral venous blood of patients with ischemic heart disease (IHD) with reference to severity of coronary and myocardial insufficiency and clinical symptoms. Thyroid hormones (TH) were examined in patients with stenosing atherosclerosis of the coronary arteries with incipient angina pectoris (IAP), acute myocardial infarction (AMI), chronic IHD before and after MI and postinfarction myocardial dysfunction (PIMD) depending on severity of coronary atherosclerosis. The findings were compared to hemodynamic and metabolic myocardial parameters, severity of coronary atherosclerosis assessed at coronaroangiography. It is shown that TH concentrations depend on efficiency of coronary circulation and characteristics of myocardial metabolism. IHD patients have isometric TH levels before MI, conversion of T4 into T3 being inhibited. After MI and development of PIMD at the compensation stage T4 and T3 levels lowered under control levels. This reflects intensity and pattern of metabolic processes in the myocardium. In intact myocardial function T4/T3 in the above patients was above the control levels because of high concentration of serum T4. In development of acute coronary syndrome the level of T3 fell while that of T4 went up due to suppression of its deiodination.