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Changes in the parameters of intra-tumor and remotely located microvessels during the growth of glioblastoma implanted in the brain of rats.

The morphological method was used to study the structural characteristics of intracellular and remotely located microvessels during the growth of glioblastoma implanted in the right hemisphere of the rat brain. The studies were carried out for 6 hours to 18 days after the implantation of the tumor. An increase in the proportion (in %) of microvessels with a wide diameter was recorded both in the tumor itself and in remote areas of the tissue of both hemispheres of the brain. A similar trend of changes took place in the dynamics of microvascular areas on sections of the ear of rats that do not have a common blood circulation with the brain. The data obtained make it possible to justify the expediency of further identification of remote tests to assess the parameters of the tumor and the therapeutic measures being developed. 
Key words: glioblastoma, morphometry, diameter of microvessels. 
 