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Assessment of an online calculator’s vancomycin dosing and exposure appropriateness in persons who inject drugs with methicillin‐resistant Staphylococcus aureus bloodstream infections

While the gold standard for calculating AUC involves two steady‐state concentrations, online calculators can empirically estimate AUC and other pharmacokinetic (PK) parameters. In patients with potentially altered PK, such as persons who inject drugs (PWID), the reliability of these predictions is unclear. Our objectives were to characterize the PK of vancomycin in PWID with methicillin‐resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI) and to assess the impact of these PK parameters on dosing regimens when compared to regimens generated by an online calculator.