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Laser Scanning Cytometry for the Pharmaceutical Industry

In analysis applications for the pharmaceutical industry, there is a parallel tradeoff between high throughput and high information content. High throughput is necessary for screening applications where libraries need to be screened for activity against a target, typically using highly automated instruments that measure a single feature of the sample, and are especially well suited for detecting interactions between molecules in solution. High content analysis involves both having many detectors as well as extracting many features for each detector, and is applied typically to cellular models. High content analysis is necessary to effectively detect interactions that may affect only a subset of the cells in the sample (heterogeneous analysis), or to measure the effect of an agent on the distribution of constituents within a cell (sub-cellular analysis), or to study the relations amongst cells in a heterogeneous population.