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Description and use of the CS‐3000 blood cell separator for single‐donor platelet collection

A new computer‐controlled seal less continuous flow blood cell separator has been developed to harvest platelets, plasma, or leukocytes and perform plasma exchange. One hundred seven platelet collection procedures were performed using an instrument prototype during developmental evaluation of a number of differently configured platelet collection chambers. An average of 3.6 (range 2.6‐5.5) × 1011 platelets was collected during a 90‐minute period (blood withdrawl rate, 32 ml/minute) with the best chamber. Only a small number of other cells, from 0.1 to 0.2 times 109 white blood cells and 0.7 to 1.0 times 109 red cells was collected with the platelets. Total procedure time averaged 115 to 120 minutes and included 5 minutes to install the blood processing pathway, 10 minutes to prime the system under computer control, 5 minutes to return donor erythrocytes at the completion of the procedure, and 5 minutes to remove the processing set and resuspend the platelets. The average donor platelet count declined 48 times103per μ (19%) by the completion of the procedure, and, with the exception of a decline in inorganic phosphorus from 3.4 to 2.5 mg per dl, no unexpected changes in serum chemistry levels were seen.