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A Comparison of Some Statistical Procedures for Therapeutic Equivalence Clinical Trials with Survival Endpoints

The primary objective of therapeutic equivalence clinical trials is to show that a new treatment is not inferior to or has the same efficacy as a standard treatment. When the primary endpoint of these trials is the time to an event (or survival time) and the data may be censored, we present in this paper some Monte-Carlo simulation results for the comparison of some statistical procedures that have been used for the analysis of the data collected from these trials.