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Joint capsule loosening by high-intensity pulsed ultrasound

High-intensity ultrasound in pulsed wave mode is investigated as a new treatment method for joint contracture. Joint contracture is characterized by an abnormally thickened, shortened joint capsule that tightly constrains joint movement. Non-invasive treatment typically involves lengthy physical therapy. Disappointing recovery is not uncommon and invasive interventions are frequently required. A new, non-invasive therapeutic strategy is highly desired. Of particular interest in this study is the application of high intensity pulsed ultrasound. Using an ex vivo model, here we investigate the effect of pulsed-waved ultrasound of high intensity (PUHI) on tendons and ligaments of swine. Changes of the B-mode images of the tissues before and after the application of PUHI were determined and correlated with the mechanical and histological examinations. Our preliminary results show that PUHI exerts significantly mechanical disruption on the tissues, while the changes can be successfully monitored by a B-mode-image-based approach.