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Analgesic Effect Of Dioclenol And Dioflorin Isolated From Dioclea Grandiflora

The analgesic activity of dioflorin and dioclenol, two constituents of Dioclea grandiflora Mart., has been studied in mice. It was found that dioclenol (10 mg/kg, i.p.) and dioclenol (10 mg/kg, i.p.) were effective in the acetic acid-induced writhing and tail immersion tests. These observations suggest that dioflorin and dio-clenol possesses central antinociceptive activity.