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Prospective Comparison of Rapid Urease Tests (Pyloritek, Clo-test) for the Diagnosis of H. Pylori Infection in Symptomatic Children: A Pediatric Multicenter Study. 480

Rapid urease tests have been routinely used in the Gastrointestinal endoscopy suites. PyloriTek is a new rapid (1 hour) urease test which is comparable to standard CLO-test in adults. Limited data are available on the sensitivity of PyloriTek in the pediatric population. Aim: To compare the performance of two rapid urease tests (PyloriTek; Serim Corp. and CLO-test; Delta West) using histologic examination as a gold standard.Methods: In a prospective study, children were enrolled by four pediatric GI clinics. Children with previous history of Hp infection or recent antibiotic treatment were excluded. Gastric antral biopsies were tested for both rapid tests and histology. Results: 144 patients (M/F=70/74) with the mean age of 11.6 years were investigated. PyloriTek and CLO-test had a concordance of 139/144(96.5%) and discordance of 05/144(3.5%). Comparison between histology and both tests are seen in Table: