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Effects of Preemptive Single Dose Sustained Release Non-Steroidal Anti-Inflammatory Drugs on Postoperative Complications Following Third Molar Surgery

Objective: The aim of this study was to compare the effectiveness of two preemptive sustained-release nonsteroidal antiinflammatory agents in terms of pain, edema and trismus following third molar surgery. Method: Overall, 30 patients with double-sided vertically positioned impacted third molars were included in this study. The study was randomized and double-blinded. 30 minutes before the surgery, patients were given sustained-release (SR) dexketoprofen trometamol 75 mg and following the surgery the drug administration continued postoperatively for 1 week, once a day. 2 weeks later, the same procedure was applied for the counterside impacted third molar with sustained-release (SR) diclofenac sodium 75 mg. The pain was assessed postoperatively by VAS levels at the 6th, 8th, 12th, 24th and 48th hours and on the 3rd, 5th, and 7th days. Edema and trismus measurements were evaluated on the postoperative 2nd and 7th days. Result: There was a statistically significant difference between the groups in VAS levels at 6th, 8th, 12th, 24th, and 48th hours, and on the 3rd and 5th days (P <0.01). VAS levels of dexketoprofen trometamol SR group had lower VAS levels than diclofenac sodium SR group. There was no statistically significant difference between the groups in terms of trismus and edema measurement averages on the 2nd and 7th days (P <0.05). Conclusion: Dexketoprofen trometamol SR and diclofenac sodium SR are similarly effective for the reduction of edema and trismus following impacted third molar surgery; however, dexketoprofen trometamol SR is found to be more efficient in reducing pain.