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The cellular basis for the induction of antigen‐specific T8 suppressor cells

The cellular basis for the generation of antigen‐specific T8 suppressor cells with high doses of antigen has been studied. We separated the T4 subset of human T cells into T4+2H4+ and T4+2H4− subpopulations with a recently developed monoclonal anti‐2H4 antibody. T8 cells could be consistently activated to suppress a primary anti‐2,4‐dinitrophenyl (DNP) antibody response in vitro with unfractionated T4 cells or with the T4+2H4+ subset but not the T4+2H4− subset. In contrast, the T4+2H4− subset functioned as the helper inducer for the anti‐DNP antibody response. With keyhole limpet hemocyanin (KLH)‐stimulated T4+2H4+ cells we could efficiently induce antigen‐specific suppressor activity of fresh T8 cells. In contrast, the T4+2H4+ subset could not effect suppression in the absence of T8 cells. Our findings indicate that the T4+2H4+ subset of human T cells is the suppressor inducer of specific T8 cells in an antigen‐specific DNP‐KLH system.