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Anti-inflammatory Activity of the Aqueous Leaf Extract of Ixora coccinea.

ABSTRACT The aim of this study was to investigate the anti-inflammatory potential of an aqueous leaf extract (ALE) of Ixora coccinea. (Rubiaceae) in rats after oral administration (500, 1000 and 1500 mg/kg). This was done using the carrageenan-induced paw edema (acute inflammatory model) and cotton pellet granuloma tests (chronic inflammatory model). In the former test, ALE significantly impaired both early and late phases of the inflammatory response and also the edema maintained between the two phases. In the latter test, it significantly suppressed granuloma formation (only highest dose tested). Collectively, these data show promising anti-inflammatory activity against both acute and chronic inflammation. ALE showed strong antihistamine and antioxidant activities that can account for its anti-inflammatory potential. In addition, inhibition of prostaglandins and bradykinins may play a role.