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[Antioxidant effect of metallothioneins in acute bromobenzene poisoning in mice].

An increase in the content of malondialdehyde (MDA) and endogenous metallothioneins (MT) in the liver of mice 1 day after intraperitoneal injection of bromobenzene (0.5-2 g/kg) has been found. An exogenic zinc-MT polymer injected to mice decreases the basal and xenobiotic-induced MDA level in the liver and blood plasma and decreases the acute toxicity of bromobenzene. The mixture modelling zinc-MT composition (albumin, cysteine and zinc) possesses no such properties. A conclusion is made that the protective effect is specific for the MT structure and is induced by antioxidant properties of MT.