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Studies on the gastric anti‐ulcer activity of hypolaetin‐8‐glucoside

The gastric anti‐ulcer activity of hypolaetin‐8‐O‐β‐D‐glucoside (H‐8‐G), a flavonoid isolated from Sideritis leucantha, has been studied in rats. This compound significantly reduced gastric lesions induced by ethanol or acetylsalicylic acid (ASA), with an increase in mucus production. In the pylorus‐ligated rat, H‐8‐G did not affect the volume of gastric secretion but decreased its acidity and peptic activity. The anti‐ulcer activity of this flavonoid does not depend on stimulation of cell proliferation in the rat gastric mucosa. Our results suggest that H‐8‐G activity is related to its cytoprotective effects [mediated by endogenous prostaglandins (PGs) and associated to an increase in gastric mucus production] alongside with its moderate antisecretory effects.