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52B: THE ROLE OF ANTI-OSTEOGENIC SIGNALING IN THE PATHOPHYSIOLOGY OF CRANIOSYNOSTOSIS IN INFANTS

Background: The importance of anti-osteogenic signaling molecules (Noggin, BMP-3) in normal cranial suture fusion has recently been demonstrated in a murine model but the role of these molecules in pathophysiology of premature suture fusion (craniosynostosis) in humans remains unknown. The aim of this study was to investigate the regional variations in osteoblast function and the expression of osteogenic signaling molecules (noggin, BMP-3, Runx-2) in infants with craniosynostosis.