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Tumour‐infiltrating lymphocytes in colorectal cancer with microsatellite instability are activated and cytotoxic

Patients with colorectal cancer that display high‐level microsatellite instability (MSI‐H) appear to have a better prognosis. This may be explained by the pronounced T cell infiltrate seen in MSI‐H tumours that is related to a specific antigen‐driven immune response. The nature of tumour‐infiltrating lymphocytes in colorectal cancers was investigated using quantitative real‐time polymerase chain reaction (PCR) and immunohistochemistry.