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Antioxidative and Antiinflammatory Effects of Green Tea Seed Coat Extract in BALB/C Mice Injected with LPS

The EtOH extract of the green tea seed coat (GTSC) was fractionated with a series of PE, EtOAC, and BuOH. Among them, EtOAC extract showed the highest antioxidative and antiinflammatory effects in RAW cell line. Thus, this study was carried out to evaluate the protective properties of GTSO EtOAC extract (250 and 500mg/kg BW) administration on acute endotoxin‐induced oxidative stress, BALB/C male mice were gavaged with or without GTSC extract for 1 week. Endotoxin shock was then induced by intraperitoneal injection of LPS(100mg/kg BW). Plasma MCP‐1 and sVCAM‐1 levels were not different among groups with LPS intraperitoneal injection. TNF‐α levels of plasma were significant lower in the EtOAC+LPS groups injection group than LPS group at 1h and 4h after intraperitoneal injection. Hepatic TBARS was lower in EtOAC+LPS groups than LPS group. Liver catalase activities were slightly higher in the EtOAC 500+LPS group than in the LPS group at 1 h, 2h and 4 h after intraperitoneal injection. These results demonstrate GTSC extract may ameliorate inflammatory diseases through inhibition of plasma TNF‐α and hepatic TBARS levels, which may be mediated partially by anti‐oxidative effect of GTSC.