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Serotonin and Apoptosis: Studies on Rat Lymphocytes

Objective: The apoptogenic potential of serotonin (5-hydroxytryptamine) on mitogen-stimulated lymphocytes was studied in primary cultures of rat spleen cells, in two sets of experiments. Methods: Apoptosis was measured by morphologic criteria and flow cytometry. Results: In both assays, serotonin, at a concentration producing half-maximal inhibition of lymphocyte proliferation, significantly increased the basal levels of apoptosis. Conclusion: An apoptotic mechanism should be taken into account when considering immunoinhibition induced by serotonin.