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Antiimplantation mechanism of action of embelin in rats

The antiimplantation mechanism of action of embelin has been studied in rats. Its administration caused a significant reduction in ovarian and uterine wet weight. Ovarian histology revealed newly formed corpora lutea and the biochemical constituents were decreased. Similarly, the uterus of pregnant treated rats did not show any preparative changes, decidualization, apposition reaction, stimulation or proliferation. Biochemical constituents also behaved as those of cyclic rats even on the day of implantation. These findings suggest that the administration of embelin to pregnant rats keeps the ovary and uterus in a cyclic condition.