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Short‐Term Clinical Exposure Evaluation of a Second‐Generation Electrically Heated Cigarette Smoking System

This randomized, controlled, forced‐switching, open‐label, parallel‐group study in 100 adult male and female smokers of conventional cigarettes evaluated 8 biomarkers of tobacco smoke exposure. After baseline exposure determinations, adult smokers were switched to a second‐generation electrically heated cigarette smoking system (EHCSS) for 8 days in a clinical setting. After 8 days of smoking the EHCSS biomarkers of exposure decreased by 43% to 85% compared to baseline. After correction for residual effects (carryover effects due to long elimination half‐life and non‐tobacco‐confounding sources of exposure), reductions in exposure ranged from 59% to 97%. Results from this short‐term clinical exposure study indicate that switching from a conventional cigarette to a second‐generation electrically heated cigarette smoking system substantially reduced the exposure to several measured potentially harmful constituents of tobacco smoke.