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2-HEMA-g-Na-PCMS: A Novel Polymeric Matrix for the Controlled Release of Paracetamol

2-hydoxyethyl methacrylate (2-HEMA) was graft copolymerized with sodium salt of partially carboxymethylated starch (Na-PCMS). Thus prepared, graft copolymer (2-HEMA-g-Na-PCMS) was used as a polymeric matrix for preparing controlled-release tablets of paracetamol. Tablets of standard specification were prepared using the wet granulation method. Ingredients utilized for tablet preparation were 2-HEMA-g-Na-PCMS graft copolymer, paracetamol and excipients. Tablets were characterized for disintegration time (min), hardness, angle of repose and percent friability. It was found that tablets prepared by the compression of graft copolymer, excipients and drug in specified ratios resulted in an excellent controlled-release tendency of paracetamol.