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Influence of chemical sympathectomy on endotoxin lethality in young rats.

These studies were aimed to assessing the contribution of catecholamine imbalance in the lethal activity of bacterial endotoxins. Chemical sympathectomy in newborn rats by either guanethidine, bretylium tosylate, or 6-hydroxydopamine (6-OHDA) did not alter the survival of animals as compared to saline-pretreated newborn rats challenged with endotoxin. Tolerance to endotoxin lethality could be established in 6-OHDA-treated baby rats at least as well as in saline-injected controls. Since cortisone protected the 6-OHDA-pretreated sucklings against the lethal effects of endotoxin, it seems that the protective ability of the hormone is not an effect of the known anticatecholamine-like activity of the gluco-corticoids. All evidence indicates that endotoxins, like corticosteroids, directly influence a common receptor/effector system capable of committing the direction of homeostasis in the hepatic tissue.