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[Chronopharmacodynamics of betacap (long-acting propranolol) in patients with hypertension stage II].

Chronopharmacodynamics of long-action propranolol hydrochloride-betacap (Natko, India) was studied in 48 patients with essential hypertension stage II. Six randomized groups of patients were given a single dose of 80 mg a day: at 7, 10 a.m., 1, 4, 7 and 10 p.m. Before the treatment, 1.5, 2, 3 and 4 hours after betacap intake, 10 days after the treatment course noninvasive tests of hemodynamics were made. Maximal negative chronotropic and hypotensive effect was demonstrated at 10 p.m., 7 and 10 a.m. The hypotensive effect was hemodynamically insured either through inhibition of the heart rate alone in the intake at 1 and 4 p.m. or both inhibition of the heart rate and decreased total peripheral vascular resistance in the intake at 7 a.m. and 10 p.m., or negative inotropic action of betacap combined with negative chronotropic effect in the intake at 10 a.m. and 7 p.m. Energy consumption of the myocardium was reduced. A circadian rhythm of sensitivity to betacap is shown for total and specific peripheral resistance, rational coefficient, diastolic pressure, energy consumption with acrophase at early morning hours, left ventricular contractility at night time, systolic pressure, double production, stroke index, effective activity of the heart at day time.