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Childhood psychosis after H1N1 influenza.

To the Editor: We report two cases of transient childhood psychosis (CP) following the presentation of H1N1 influenza at the outpatient clinic of Mackay Memorial Hospital in Taipei, Taiwan, from July 2009 to March 2010. The aim of this case report is to clarify that first transient CP as a result of H1N1 influenza is different with other early-onset schizophrenia or antiviral drug-induced psychosis. Second, although it is well known that there is a strong association between maternal influenza infections with the increasing risk of psychosis in adult offspring, there are limited studies that show the direct H1N1 influenza results in CP. The underlying pathomechanism of such transient CP may be immunological cross-reactivity, and further immunologic research is warranted.