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Plasma-free amino acid profiling of nasal polyposis patients.

AIM AND OBJECTIVE
Mechanisms in etiopathogenesis of nasal polyposis; particularly, it is not clear whether the amino acids contribute in a causal way to the development of the disease. The aim of this study was to determine the plasma-free amino acid profile in patients with nasal polyposis and to compare the results with the healthy control group.


MATERIALS AND METHODS
This is a prospective controlled study of the Ear-Nose-Throat Department of the Our University Faculty of Medicine between April 2017 and April 2018. The study included 25 patients with nasal polyposis and 20 healthy control groups. Plasma-free amino acid profiles levels were studied in serum samples taken from the patient group and the healthy control group.


RESULTS
In patients with nasal polyposis; 2-Methyl histidine (2-MHIS), arginine (arg), asparagine (asn), citrulline (cit), cystine (cys), glutamic acid (glu), serine (ser), taurine (tau), tryptophan (trp) , lysine (Lys), ornithine, homocitrulline, norvaline, argininosuccinic acid plasma concentrations were significantly higher than healthy control group (p <0.05). Also, Gamma-aminobutyric acid (Gaba) plasma concentration was significantly lower (p <0.03).


CONCLUSION
To reveal the interactions and mechanisms between nasal polyposis and plasma-free amino acid profiles may help us to understand the complex etiopathogenesis of nasal polyposis. It is important to determine the possibility of using the information obtained to prevent recurrence and to develop effective treatment strategies. Due to its pathophysiological significance, our result may shed light on the development of potential drug therapies and individual diet programs targeting the imbalance in plasma free amino acid profiles.