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[Characteristics of sexual maturation of girls with juvenile hyperplasia of the thyroid gland].

Overall 69 girls with stage II and III juvenile hyperplasia of the thyroid without any clinical signs of pubertal abnormality were examined. Of these, 2/3 had the normal content of circulating thyroid and thyrotropic hormones in the blood serum. In prepubertal girls, the age-associated basal concentrations of gonadotropins and sexual steroid were discovered, whereas in puberty, there was a significant increase of the content of luteinizing hormone, prolactin, estradiol (a two-fold increase) and progesterone (a ten-fold increase) in the second phase of the menstrual cycle, which attested to its ovulatory nature. In 1/3 of the girls, subclinical hypothyrosis with a significant rise of the level of thyrotropic hormone associated with normal or lowered concentrations of triiodothyronine or thyroxine was diagnosed. In addition, the metabolic markers of the discoordination of the hypothalamo-hypophyseal-gonadal system were revealed: an increase of the content of luteinizing hormone and prolactin associated with the low levels of estradiol and progesterone.