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The Replication Factor A2 N‐Terminus Is Required for Proper Progression Through Meiotic Divisions

Meiosis is an essential process in sexually‐reproducing organisms for the generation of haploid gametes. In humans, defects in meiosis are known to lead to cellular diseases caused by nondisjunction (e.g., Down Syndrome and Turner Syndrome), translocation, or loss/gain of parts of chromosomes. Since many of the proteins involved in the meiotic process are conserved from humans to yeast, the budding yeast Saccharomyces cerevisiae provides a model system for the induction and study of meiosis. During meiosis, programmed double‐stranded breaks (DSBs) occur at a high frequency throughout the genome, initiating meiotic recombination and ensuring proper chromosome segregation. Due to 5′‐>3′ resection of the breaks, single‐stranded DNA (ssDNA) intermediates are formed. A heterotrimeric protein complex, called Replication Protein A (RPA), binds to the ssDNA to stabilize and direct its processing, thereby protecting the integrity of the genome.