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Determination of Chromosomal Aneuploidy Using Paraffin‐Embedded Tissue

Tissue processed in pathology departments is generally fixed in formalin and embedded in paraffin blocks. Depending upon the nature of the question asked, two different approaches are taken to analyze this material and are presented in this unit. If information about the spatial relationship of one cell to another is not necessary, a thick section of tissue can be disaggregated and the resulting intact nuclei analyzed. The number of hybridization signals per nucleus is tabulated; variance from two hybridization signals per nucleus indicates aneuploidy. If the spatial relationship of one cell to another needs to be preserved, intact tissue sections on glass slides can be analyzed. Tissue processed in pathology departments is generally fixed in formalin and embedded in paraffin blocks.