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INTERACTION BETWEEN ASPIRIN AND INDOMETHACIN IN THE TREATMENT OF RHEUMATOID ARTHRITIS

The effect of aspirin upon serum concentration and excretion of 14C‐2‐indomethacin was studied in eight patients with rheumatoid arthritis. With concurrent aspirin ingestion, there was a significant decrease in serum 14C levels, together with a decrease in urine excretion compared to preaspirin levels. In one patient studied, there was a corresponding rise in fæcal 14C excretion. The study showed interference between aspirin and indomethacin, the mechanism possibly being due to decreased gastro‐intestinal absorption. This could account for clinical reports that the combination of the two drugs was no better than aspirin alone.