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Effects of a small serosal hydrostatic pressure on sodium and water transport and morphology in rabbit gall‐bladder

1. In order to investigate the mechanism of serosal pressure‐induced inhibition of isosmotic fluid transport, the effect of 4·5 cm water serosal pressure on spontaneous water transfer (Jv) in rabbit gall‐bladders was measured (in the presence of a supporting soft nylon net on the mucosal side) in a modified Ussing chamber. This allowed unidirectional Na+ fluxes ([Formula: see text] and [Formula: see text]), transepithelial potential difference and resistance (Rt) to be measured simultaneously. The effects of the serosal pressure were also investigated by light and electron microscopy.