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Investigating the causes of biosensor SNR decrease by means of fault tree analysis

The causes of biosensor signal-to-noise ratio decrease have been investigated by means of fault tree analysis (FTA) relying on fuzzy reasoning to account for uncertainty. Using the fuzzy FTA methodology proposed herein, all ultimate causes or combination of causes, attributed to the device components, the interaction of the device components or the human factors, that are responsible for or contribute to the above event have been recognised and quantified based on; (a) measurements for the deterministic contributors, and (b) experience for the stochastic contributors. The methodology has been implemented in the case of bilayer lipid membrane biosensors and has proven to be an efficient tool for internal diagnostics and fault compensation.