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Guidelines for therapy and optimal dosages of coagulation factors for treatment of bleeding and surgery in haemophilia

1. Episodes of bleeding in people with haemophilia require replacement therapy. 2. An accurate diagnosis of the type of bleeding disorder and knowledge of the baseline levels of factor VIII and factor IX are essential. 3. Factor therapy must be administered promptly in doses adequate to control bleeding and continued for sufficient duration to ensure that haemostasis or wound healing is complete. 4. Any interventive procedure or invasive dental treatment in haemophilia must be covered with factor replacement therapy. 5. The presence of an inhibitor must be excluded before undertaking any surgery or dentistry in people with haemophilia. 6. Elective surgery or even emergency surgery should only be undertaken if adequate supplies of factor replacement are available for a full course of prophylactic treatment.