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THE ROLE OF THE PREMORBID THYROID STATUS IN THE FORMATION OF CELLULAR IMMUNITY AND THE CONSEQUENCES OF CHEMOTHERAPY IN PATIENTS WITH DESTRUCTIVE PULMONARY TUBERCULOSIS

The indicators of the state of the thyroid gland and cellular immunity were studied in patients with newly diagnosed pulmonary tuberculosis (TP). A comparative analysis of the efficacy of anti-tuberculosis chemotherapy in patients with thyroid pathology and unchanged thyroid status was carried out. Changes in the echostructure of the thyroid gland were found in 51% of patients. In the case of TP in combination with an altered echostructure of the thyroid gland, a decrease in the level of free thyroxine and an increase in the level of TSH were found as compared with the group of patients with TP without thyropathy. The interleukin-6 level in patients with LT combined with thyroid pathology is significantly lower than in patients without thyropathy. The effectiveness of chemotherapy in tuberculosis patients without thyropathy is higher than in tuberculosis patients with thyropathy. It was concluded that it is necessary to screen the state of the thyroid gland in order to identify hidden disorders of the functional activity of the thyroid gland in order to correct them, restore the cytokine balance and increase the effectiveness of anti-tuberculosis chemotherapy