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Design, Synthesis and Characterization of Pyrimidine based Thiazolidinedione Derivatives

Novel thiazolidine-2,4-dione (TZD) based pyrimidine derivatives have been synthesized by
Knoevenagel condensation reaction between thiazolidine-2,4-dione and amino pyrimidinyl aliphatic
aldehydes followed by heterogeneous metal reduction. Synthetic strategy involved nucleophillic
substitution of hydroxyl protected six membered aliphatic chain on 4,6-dichloropyrimidine followed
by Suzuki coupling. This approach is regioselective, efficient and versatile for synthesis of such analogs