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VP25.08: Prenatal visualisation of the torcular herophili in the expert assessment of the posterior fossa: a prospective study

Results: We found an interaction effect in terms of an increase of connectivity strength between the left thalamus and the left insular region in the fetus only for mothers with high PTB risk and with anxiety. Conclusions: The functional interplay between the insular region and the thalamus underpins salience attribution, which is a key cognitive asset for survival in the extrauterine environment. Accordingly functional synchronisation of these regions, as part of the Salience Network, has been previously reported already at birth. We report novel evidence showing how maternal mental states may impact on fetal functional neurodevelopment. We argue that maternal anxiety may influence functional connectivity patterns through the increase of fetal cerebral blood flow, stemming from reduced uteroplacental perfusion as a consequence of norepinephrine release.