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Visualization of Replicating Herpes Simplex Virus in Cervical Dorsal Root Ganglia of Mice Following Explant of Individual Ganglion Onto Susceptible Indicator Cells

Herpes simplex virus (HSV) establishes a latent state in the sensory ganglia of the peripheral nervous system of its natural or experimental host following primary infection. At various times thereafter, the virus can be reactivated from the latent state whereby it migrates back to the periphery and sometimes initiates a clinical syndrome referred to as recurrent disease.