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Development Strategy of Endodontic Filling Materials Based on Engineering and Medical Approaches

: This article is a literature review aimed at presenting the general state of knowledge in manufacturing engineering and materials engineering to develop engineering materials applied for endodontic treatment as filling materials. Particular attention was paid to theoretical analyses concerning the selection of methods for developing and obturating root canals and discussing the results of experimental studies available in the literature. These activities aimed to compare the importance of the most commonly used endodontic filling materials based on gutta-percha or polymeric polyester materials, commonly known as resilon, respectively. The motivation to take up this complex, multi-faceted topic in this paper is the extent of caries, periodontal disease, and other oral diseases in 3 to 5 billion people, often affecting toothlessness and contributing to an increase in the index of disability-adjusted life years (number). Endodontics is an important element of the authors’ concept of Dentistry Sustainable Development (DSD) > 2020. The principles of qualifying patients for endodontic treatment are discussed. The introduction of rotary tools, especially manufactured from Nitinol alloy, to develop root canals and the latest thermohydraulic and condensation techniques for obturation guarantee progress in endodontics. The “Digital Twins” methodology was used, rooted in the idea of Industry 4.0 and the resulting idea of Dentistry 4.0, as well as knowledge management methods, to perform experimental research in virtual space, concerning methods of developing and obturating the root canal and assessing the tightness of fillings. Microscopic visualization methods were also used. Significant factors determining the effectiveness of endodontic obturation are the selection of the filling material and the appropriate obturation method. The generalized dendrological matrix of endodontic filling materials considers the criteria of mechanical strength influencing the potential root fracture and the quality of root canal filling. The results of the SWOT point analysis (strengths and weaknesses, opportunities, threats) were also compared. For both filling materials, the weaknesses are much less than the strengths, while the threats are slightly less than the opportunities for the gutta-percha-based material, while for resilon the opportunities are much smaller than the threats. It requires the application of an appropriate development strategy, i.e., MAXI-MAXI in the case of a filling material based on gutta-percha and MAXI-MINI in the case of resilon. Therefore, the analysis of these experimental data does not indicate the real competitiveness of resilon for the gutta-percha-based material. This material deservedly maintains its strong position as the “Gold Standard of Endodontics”.


General Characteristics of the Problem
The challenges of modern civilization take many aspects, and it turns out that they can and should be met in various, even surprising, modes. Most generally, they are about sustainable development, consisting of satisfying the justified needs of all people with respect for the rights and expectations of everyone, in ensuring general prosperity with possibly equal access to all goods by all people and with the wide development of partnership between them, to ensure peace as one of the highest values and with full care for the development of the planet and the preservation of its natural resources for future generations. These general assumptions and expectations, defined as the five Ps of sustainable development [1] (Figure 1), were at the basis of the UN designating seventeen Sustainable Development Goals (SDGs) [2]. Among these SDGs, the third designated SDG on health and all related aspects occupies a prominent place. This goal requires action in various areas and requires an appropriate organization and modernization of health systems specified in the EU4 Health these various professional groups should get to know each other's issues because only the synergy of knowledge and actions can bring beneficial effects to patients, and it is their welfare that is at stake here. This is the overarching message. Therefore, it is not true as if it would seem to someone that on the one hand general and the other hand detailed content, as indicated above, are superfluous and should be omitted in part or in full, or even worse, included in various parts, e.g., different papers, because then a large group of potentially interested readers may never find these remaining parts. Only a holistic and monographic approach to the problem can achieve the previously mentioned, assumed goals of such a message. If it were otherwise, it would mean that the purpose of this synergistic cooperation of people of different professions would be destroyed to ensure, within the scope specified in this article, the possibility of implementing the 3rd SDG on a global scale.
An illustration of this problem is a tree photographed by the authors of this article in the forests of the Roztocze National Park in southeastern Poland, not far from the very famous historical town of Zamość, typical of the European Renaissance, included in the UNESCO cultural heritage list (Figure 2a). The following basic issues coming from a common virtual trunk are analyzed, i.e., features of use, reliable use, guaranteed utility functions, ensured mechanical properties, ensured shape, and possible processing. The diagram in Figure 2b shows a symbolic crosssection of a virtual trunk split into three parts, considering the analyzed aspects from three fundamentally different points of view, i.e., materials science, manufacturing engineering, and dentistry. They come from a common trunk, illustrated by centrifugal arrows oriented towards each other under an angle of 120°. The solution to this problem is materials engineering, so not including mainly dentistry including endodontics as one of its parts. Therefore, it is necessary to analyze the aspects mentioned above in the realities of each of the above-mentioned scientific disciplines. These aspects cannot be omitted or simplified to such an extent that it is not understandable for readers representing two other than their own professional experience and knowledge range. A positive result of dental treatment, and in this case endodontic treatment, should be understood as a specific virtual The following basic issues coming from a common virtual trunk are analyzed, i.e., features of use, reliable use, guaranteed utility functions, ensured mechanical properties, ensured shape, and possible processing. The diagram in Figure 2b shows a symbolic cross-section of a virtual trunk split into three parts, considering the analyzed aspects from three fundamentally different points of view, i.e., materials science, manufacturing engineering, and dentistry. They come from a common trunk, illustrated by centrifugal arrows oriented towards each other under an angle of 120 • . The solution to this problem is materials engineering, so not including mainly dentistry including endodontics as one of its parts. Therefore, it is necessary to analyze the aspects mentioned above in the realities of each of the above-mentioned scientific disciplines. These aspects cannot be omitted or simplified to such an extent that it is not understandable for readers representing two other than their own professional experience and knowledge range. A positive result of dental treatment, and in this case endodontic treatment, should be understood as a specific virtual imaginary result vector resulting from the vectorial summation of all component vectors corresponding to the mentioned issues for which corresponding colors were selected appropriately for each of the three points of view. Only the interaction and synergy of these factors can produce a positive result, and this symbolic virtual result vector will acquire both the appropriate value and the direction and turn.
Therefore, the aim of this paper is a comprehensive presentation of the design conditions of engineering endodontic filling materials, which are one of the typical dedicated engineering materials, and multi-faceted analysis of the conditions of their use and the quality and durability of the performed endodontic fillings (Figure 3). imaginary result vector resulting from the vectorial summation of all component vectors corresponding to the mentioned issues for which corresponding colors were selected appropriately for each of the three points of view. Only the interaction and synergy of these factors can produce a positive result, and this symbolic virtual result vector will acquire both the appropriate value and the direction and turn.
Therefore, the aim of this paper is a comprehensive presentation of the design conditions of engineering endodontic filling materials, which are one of the typical dedicated engineering materials, and multi-faceted analysis of the conditions of their use and the quality and durability of the performed endodontic fillings (Figure 3). For this analysis, a wide set of methods was used, not only in materials science and manufacturing engineering, but also in management engineering and knowledge management, and technological foresight. It is an original approach, however, requiring a consistent analysis of the impact of all component factors, not just selected ones. The aim of this paper is also to present the general state of knowledge on endodontic treatment, with particular emphasis on theoretical analyses regarding the selection of root canal development and obturation methods, as well as to discuss the results of experimental studies available in the literature in order to compare the validity of the selection of the most commonly used filling materials in endodontics. They are suitably based on gutta-percha or polymeric polyester materials, commonly known as resilon. The results of experimental studies with the use of stereoscopic and scanning electron microscopes as well as the results of the SWOT analysis (Strengths-Weaknesses-Opportunities-Threats) and the analysis of the dendrological matrices are presented.

Scope of the Development of Manufacturing Technologies and Engineering Materials, Taking into Account the Specifics of Dental Engineering
It should be realized that the methodological aspects of product development, from scientific research to engineering design and also manufacturing, are not really different, whether they are spacecraft, airplanes, cars, machine tools, dental implants, or dental restorations [5][6][7][8]. For obvious reasons, the working conditions or the use of each of these products and the engineering materials used vary in various industries and areas of life. For this analysis, a wide set of methods was used, not only in materials science and manufacturing engineering, but also in management engineering and knowledge management, and technological foresight. It is an original approach, however, requiring a consistent analysis of the impact of all component factors, not just selected ones. The aim of this paper is also to present the general state of knowledge on endodontic treatment, with particular emphasis on theoretical analyses regarding the selection of root canal development and obturation methods, as well as to discuss the results of experimental studies available in the literature in order to compare the validity of the selection of the most commonly used filling materials in endodontics. They are suitably based on gutta-percha or polymeric polyester materials, commonly known as resilon. The results of experimental studies with the use of stereoscopic and scanning electron microscopes as well as the results of the SWOT analysis (Strengths-Weaknesses-Opportunities-Threats) and the analysis of the dendrological matrices are presented.

Scope of the Development of Manufacturing Technologies and Engineering Materials, Taking into Account the Specifics of Dental Engineering
It should be realized that the methodological aspects of product development, from scientific research to engineering design and also manufacturing, are not really different, whether they are spacecraft, airplanes, cars, machine tools, dental implants, or dental restorations [5][6][7][8]. For obvious reasons, the working conditions or the use of each of these products and the engineering materials used vary in various industries and areas of life. Due to the achieved level of the technological revolution of Industry 4.0, it is necessary to respect this concept in all areas of modern production [9,10]. The assumed development is to be intelligent, inclusive, and sustainable, despite the current difficult global economic situation and the accompanying problems, such as climate change, increased consumption, the depletion of traditional energy sources, threats to food safety, and the progressive aging of society, which needs a higher level and intensity of health care.
The essence of economic activity is the production of all products that can meet the market acceptance of buyers. Manufacturing is the transformation of raw materials into products through a variety of processes, machinery, and operations organized according to a well-developed plan. Therefore, the production process is about the proper use of resources: materials, energy, capital, and people. Nowadays, manufacturing is a complex activity that connects people who perform various professions and activities, using various machines, equipment, and tools, to a varying degree automated, including computers and robots, and is used to introduce to the market new products, which are often completely innovative.
In the process of introducing products to the market, three main spheres can be indicated: In each of these spheres, appropriate decisions should be made depending on the implementation stage of tasks related to the preparation of products for launch on the market. Figure 4 shows a general model of manufacturing engineering in the form of an octahedron, resulting from market activities, combining both marketing activities and market insight, as well as target distribution, promotion, and sale of manufactured products and their servicing, as well as market research to improve the current product [5-8]. Due to the achieved level of the technological revolution of Industry 4.0, it is necessary to respect this concept in all areas of modern production [9,10]. The assumed development is to be intelligent, inclusive, and sustainable, despite the current difficult global economic situation and the accompanying problems, such as climate change, increased consumption, the depletion of traditional energy sources, threats to food safety, and the progressive aging of society, which needs a higher level and intensity of health care.
The essence of economic activity is the production of all products that can meet the market acceptance of buyers. Manufacturing is the transformation of raw materials into products through a variety of processes, machinery, and operations organized according to a well-developed plan. Therefore, the production process is about the proper use of resources: materials, energy, capital, and people. Nowadays, manufacturing is a complex activity that connects people who perform various professions and activities, using various machines, equipment, and tools, to a varying degree automated, including computers and robots, and is used to introduce to the market new products, which are often completely innovative.
In the process of introducing products to the market, three main spheres can be indicated:  Marketing and sales;  Product development;  Production.
In each of these spheres, appropriate decisions should be made depending on the implementation stage of tasks related to the preparation of products for launch on the market. Figure 4 shows a general model of manufacturing engineering in the form of an octahedron, resulting from market activities, combining both marketing activities and market insight, as well as target distribution, promotion, and sale of manufactured products and their servicing, as well as market research to improve the current product [5][6][7][8]. The actual manufacturing of any product requires research as well as the development and implementation of a new technology, necessarily according to the best possible strategy, corresponding to the stage of market development of the product, as well as its advantages over emerging competitive solutions. Starting production according to such a developed technology requires industrial design, engineering design, as well as produc- The actual manufacturing of any product requires research as well as the development and implementation of a new technology, necessarily according to the best possible strategy, corresponding to the stage of market development of the product, as well as its advantages over emerging competitive solutions. Starting production according to such a developed technology requires industrial design, engineering design, as well as production planning, generally referred to as product development. Only in this way can structured production be effectively the basis of manufacturing. At the same time, the right part of the scheme consists of managerial activities accompanying every human activity, and therefore also manufacturing, including planning, organizing, motivating, and controlling.
The strategy of a company or organization dealing with production or concerning simply the production of a specific market product is developed each time, using the available possibilities, materials, technologies, and devices, as the basis for satisfying the market needs of customers through production. The technical aspects of the process of introducing a given product to the market by a manufacturing organization relate to industrial design, engineering design, production preparation, manufacturing, and service support, as outlined in the octahedron of manufacturing engineering ( Figure 3). The first phase of product design concerns industrial design related to the general description of the product's functions and the development of its general concept, including only the external form, color, and possibly general assumptions as to the connection of the main elements. The next phases include engineering design and subsequent production preparation. Engineering design, in which the design of the production system and product design can be distinguished, is not an isolated activity because it affects all other phases of introducing a given product to the market, on which it is also dependent. Product design combines three equally important and inseparable elements ( Figure 5). Regardless of the application sphere, and therefore also for medical and dental applications, and also regardless of whether it is a product applied to the human body, or whether it is any medical device or device used in medicine or dentistry, all activities undertaken in the application of engineering materials are based on the materials science paradigm, expressed by the 6×E six-expectation rule in the form of an octahedron ( Figure 5). and therefore also manufacturing, including planning, organizing, motivating, and controlling.
The strategy of a company or organization dealing with production or concerning simply the production of a specific market product is developed each time, using the available possibilities, materials, technologies, and devices, as the basis for satisfying the market needs of customers through production. The technical aspects of the process of introducing a given product to the market by a manufacturing organization relate to industrial design, engineering design, production preparation, manufacturing, and service support, as outlined in the octahedron of manufacturing engineering ( Figure 3). The first phase of product design concerns industrial design related to the general description of the product's functions and the development of its general concept, including only the external form, color, and possibly general assumptions as to the connection of the main elements. The next phases include engineering design and subsequent production preparation. Engineering design, in which the design of the production system and product design can be distinguished, is not an isolated activity because it affects all other phases of introducing a given product to the market, on which it is also dependent. Product design combines three equally important and inseparable elements ( Figure 5). Regardless of the application sphere, and therefore also for medical and dental applications, and also regardless of whether it is a product applied to the human body, or whether it is any medical device or device used in medicine or dentistry, all activities undertaken in the application of engineering materials are based on the materials science paradigm, expressed by the 6×E sixexpectation rule in the form of an octahedron ( Figure 5). The utility functions of the products expected by the customer will be ensured if the expected engineering material is used for their production and processed with the use of technology of the expected quality, in order to obtain the expected shape of the final product with the expected structure and expected mechanical and functional properties that provide these functional features of a product [5][6][7][8]. From the point of view of engineering practice, the most important task is, therefore, to design and manufacture products with The utility functions of the products expected by the customer will be ensured if the expected engineering material is used for their production and processed with the use of technology of the expected quality, in order to obtain the expected shape of the final product with the expected structure and expected mechanical and functional properties that provide these functional features of a product [5][6][7][8]. From the point of view of engineering practice, the most important task is, therefore, to design and manufacture products with all expected utility values and functional properties required for technical reasons. Modern engineering design is a complex, comprehensive process that includes closely related and mutually complementary areas of activity: material design, structural design of product forms, and technological design of product manufacturing, in a wide range including, among others, material process technologies ( Figure 5).
Currently, over 100,000 different engineering materials are known and used in the world. The results of research carried out as part of the technology foresight of Europe announced in the reports on the implementation of the projects The Future of Manufacturing in Europe (FutMan) and Manufacturing Visions the Futures Project (ManVis) indicate the expectation of producing materials with properties ordered by product users. It has been the case almost from the beginning of this millennium. Materials should be provided with an appropriately shaped structure that guarantees the required set of physicochemical properties. The production of materials on demand (MOD), meeting the needs of market producers at the right time and place, is a priority of modern material technologies and manufacturing processes. The expectation of producing materials with properties ordered by users of products fundamentally changes the methodology of material design in general and the material design of specific products. Forecasts, including European countries, enforce the classification of engineering materials due to their functional characteristics. Therefore, the type of material used is less important, and its functionality is more important. There has been a change in the assessment of the role of engineering materials, which cannot still be seen as goods in themselves, with the applications sought for them, and the market for new engineering materials is no longer the manufacturer's market. It is because new engineering materials and manufacturing processes are subordinated to the customer's needs and the functional functions of the products. Such a modified material design methodology is related to numerous activities specified in ManVis European Foresight, related to the modeling and simulation of manufacturing processes and the prediction of operational properties of materials, the development of safe material technologies and products composed of nano-structured elements, the standardization of material properties tests, especially nano-structured ones, and the development of prediction methodology behavior of new materials during operation. The scope of materials science and materials engineering as well as engineering design of products includes the correct selection of material for a given application based on multi-criteria optimization related to belonging to one of the four basic groups of materials (metals, polymers, ceramics, composites), chemical composition, conditions manufacturing, operating conditions, and the method of removing material waste in the post-use phase, as well as price conditions related to the acquisition of material, its processing into a product, the product itself, as well as the costs of post-production and post-exploitation waste disposal, as well as modeling all processes and properties related to materials [5][6][7][8].
It is this general and universal approach to solving any problem related to the engineering design of each product that requires a detailed analysis of the causes and conditions related to the use of a given material in each detailed analyzed case. It is, therefore, the basis of a wide literature review on diseases of the oral cavity, dentistry, and its special field, which is endodontics. It is because such an analysis allows dental engineers, and more generally materials engineers, to optimize material design. Such a literature review on general operating conditions for this class of products is provided in the next section of this paper.

Scope of Oral Cavity Diseases and the Endodontics within the Concept of Sustainable Dentistry Development
Caries, one of the most common infectious diseases affecting humanity [2,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] on an epidemiological scale, similarly to periodontal diseases [27][28][29][30][31][32][33][34][35] and other diseases of the oral cavity, affects 3 to 5 billion people worldwide [3,[28][29][30][31][32][33][34][35][36][37][38]. Caries is caused by the dynamic imbalance between demineralization and remineralization [3,[24][25][26][27][28][29]39,40] depending on the interaction between the tooth structure, saliva, genes, sugars, and starch derived from the diet and bacterial biofilm on the tooth surface, and depends on psychological, social, and behavioral factors [17,20,36,41]. With a low flow of saliva and a high level of sugars in the diet, influencing unfavorable conditions in the oral cavity, a set of endogenous microorganisms, referred to as biofilm as a conditioning layer for primary bacterial colonizers, promotes the demineralization process and the development of caries [42][43][44]. However, biofilm may play a different role [43,45] because bacteria can produce alkalis, especially in the presence of nitrogen [46], and some bacteria even use lactic acid as an energy source [47]. In these cases, the blocking of caries may even occur. Therefore, the development of caries depends on the synergy of sugars in the diet and the presence of a tooth biofilm [20,[48][49][50], which occurs when the pH of the tooth biofilm is lowered. Thus, the modification of the composition and metabolic activity of the tooth biofilm is indirectly dependent on nutritional factors. A protein-fat diet ensures the neutral pH of the biofilm and blocks the development of caries [51]. In contrast, a carbohydrate diet, mainly sugar, reduces the pH, favoring the development of caries [48,52]. A share of sugars in the diet above 5% of the daily energy consumption is the limit [39], which is, however, slightly higher in the presence of fluorine [53][54][55], and partly also of calcium and phosphate [56].
The balance of mineralization and demineralization processes in the oral cavity is appropriate for a healthy state [57][58][59]. The lack of this balance results in the resultant demineralization of the tooth surface, consisting in a dissolution of hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) and diffusion of its components outside [24], which promotes the development of caries. The reason for this is a decrease in pH due to the presence of organic acids, mainly lactic acid, as a result of sugar metabolism [42]. The rate of demineralization increases as pH [60] decreases below pH = 5.5 for enamel and pH = 6 for dentin. The differentiation of the pH value in different places causes an independent local and dynamic course of demineralization and remineralization in different places. There is a so-called white spot without cavitation on the enamel surface because demineralization is slower on the surface than in the subsurface enamel. When demineralization processes dominate, cavitation occurs on the surface [36,61]. Remineralization processes involving the re-deposition of calcium [62,63], sodium [64], and phosphate ions [65] are intensified in the presence of fluorine [65][66][67][68][69]. Fluorapatite provides a much lower susceptibility to the development of caries [36], as it undergoes demineralization in the enamel when the pH is lowered below pH = 4.5, which means that it is much more resistant to enamel demineralization than hydroxyapatite.
The result of caries and other periodontal diseases is removing single teeth and often complete toothlessness. Although tooth extraction, which is often not avoidable, allows for immediate problem resolution, it inevitably leads to the cessation of efficient functioning and the imbalance of the stomatognathic system. Dental cavities, which determine the number of closure pairs and affect the position of the remaining teeth, have a significant impact on the oral health-related quality of life (OHRQoL) [70]. Both oral diseases and partial, and especially complete, toothlessness cause an obvious loss of aesthetic value. More importantly, they cause the risk of numerous serious systemic complications and sometimes even cause a direct loss of life [71][72][73][74][75][76]. The development of oral diseases, in particular caries, and the resulting toothlessness has a significant impact on the disabilityadjusted life years (DALY) indicator ( Figure 6) [36].
The basis of the considerations contained in this article is the fundamental doctrinal dispute in the pages of the scientific press. The Lancet [37,38] presents a series of two provocative articles in which the authors contest the current development of dentistry, pointing to the basic errors which, in their opinion, require a radical change of approach. In their view, it is necessary to move away from interventionist treatment in favor of very broad and ubiquitous prophylaxis, requiring the egalitarian reach of almost every inhabitant of the planet with dental care. Even though all possible efforts must be made to develop prevention, such an approach is simply impossible and extremely utopian.  The basis of the considerations contained in this article is the fundamental doctrinal dispute in the pages of the scientific press. The Lancet [37,38] presents a series of two provocative articles in which the authors contest the current development of dentistry, pointing to the basic errors which, in their opinion, require a radical change of approach. In their view, it is necessary to move away from interventionist treatment in favor of very broad and ubiquitous prophylaxis, requiring the egalitarian reach of almost every inhabitant of the planet with dental care. Even though all possible efforts must be made to develop prevention, such an approach is simply impossible and extremely utopian. For this reason, in Processes [36], the authors presented their own real and competitive concept of the Dentistry Sustainable Development (DSD) > 2020 model, consisting of Global Dental The concept of the Dentistry Sustainable Development (DSD) > 2020 model includes all treatment activities undertaken by dentists, with full respect for real, possible, and necessary preventive actions, but not exclusive ones. Contemporary dentistry, apart from prevention, covers a total of five main branches covered by the principle of five Main Activities of Dentistry (5MAD) [36] (Figure 7b), where endodontics plays a prominent role as one of the several dentistry branches presented there, which should be considered interventionist dental branches. "The fifths rules" are an original approach, which is a modification of the assumptions of the behavioral strategy based on the idea of the Deming Plan-Do-Check-Act (PDCA) cycle illustrating the basic principle of continuous improve-ment [77]. In the case of evidence-based clinical caries treatment, due to the visual changes in enamel, dentin, and pulp, three caries advancement stages can be distinguished [78,79]. illustrated by the so-called caries continuum and the International Caries Detection and Classification System (ICDAS) [22,39,80,81]. Professional dental care requires an assessment of the risk of caries development for each patient. The caries development pyramid diagram (CDP) (Figure 7c) presents the different methods of the methodological approach, ranging from background level care (BLC) through preventive treatment options (PTO) to operative treatment options (OTO) [82][83][84]. One of the "Fifths rules" is for the 5D Caries Management Cycle Rules (CMCRs). On the evidence, especially in the early stages, this cycle covers the basic cyclical steps of 5D Caries Management Cycle Rules 5D (CMCRs) (Figure 7d all treatment activities undertaken by dentists, with full respect for real, possible, and necessary preventive actions, but not exclusive ones. Contemporary dentistry, apart from prevention, covers a total of five main branches covered by the principle of five Main Activities of Dentistry (5MAD) [36] (Figure 7b), where endodontics plays a prominent role as one of the several dentistry branches presented there, which should be considered interventionist dental branches. "The fifths rules" are an original approach, which is a modification of the assumptions of the behavioral strategy based on the idea of the Deming Plan-Do-Check-Act (PDCA) cycle illustrating the basic principle of continuous improvement [77]. In the case of evidence-based clinical caries treatment, due to the visual changes in enamel, dentin, and pulp, three caries advancement stages can be distinguished [78,79]. illustrated by the so-called caries continuum and the International Caries Detection and Classification System (ICDAS) [22,39,80,81]. Professional dental care requires an assessment of the risk of caries development for each patient. The caries development pyramid diagram (CDP) (Figure 7c) presents the different methods of the methodological approach, ranging from background level care (BLC) through preventive treatment options (PTO) to operative treatment options (OTO) [82][83][84]. One of the "Fifths rules" is for the 5D Caries Management Cycle Rules (CMCRs). On the evidence, especially in the early stages, this cycle covers the basic cyclical steps of 5D Caries Management Cycle Rules 5D  According to ICDAS [78,79] and the patient's pain symptoms, endodontic treatment may be undertaken as an alternative to dental extraction in the case of at least the third stage of caries advancement. For health and aesthetic reasons, dentists prefer endodontic treatment to extraction [85,86]. Clinically, there are reversible pulpopathies and pulp necrosis among pulp diseases and irreversible pulpopathies that can be treated endodontically [87,88]. Pulp necrosis is associated with the occurrence of a latent infection focus in the oral cavity for many years, most often without pain, in contrast to irreversible pulpopathy, manifested by severe spontaneous pain that requires the assistance of a dentist. Endodontic treatment is becoming more and more common, among others due to the increase in health awareness of societies [89], promotional activities in many countries [89], measures taken to eliminate negligence in preventing caries [90], and the intensification of problems in the face of aging societies and prolongation of human life [91]. Therefore, by 2026, the endodontics market is expected to grow to USD 2.1 billion with a CAGR of 4.1% [90,92].
Regardless of the aesthetic motivations, endodontic treatment aims to preserve the treated tooth as a pillar in the stomatognathic system, which allows it to assume a natural dental implant function. Endodontic treatment consists of preparing the inside of the tooth, removing the pulp complex from occlusal at the pulp horns to the apical foramina [93], and replacing a living tissue with a substitute biocompatible filling material. As a result of the root canal preparation, caries and the previously made restorations are completely removed, especially if they were made incorrectly.
The anatomical features of the treated tooth and the surrounding tissues require detailed analysis, including the crown part, the pulp chamber, and the root pulp, before qualifying the tooth for endodontic treatment. It is also necessary to identify the orifices of all root canals in the pulp chamber. The dentist undertakes further actions consisting of [94] qualifying the teeth for endodontic treatment according to the procedure mentioned above, removing the roof of the pulp chamber, identifying the mouth of the pulp chamber and the bottom of the root canal opening, and instrumenting the root canals. It is necessary to clean and, in turn, shape the root canals with care not to damage the coronal enamel and dentin. Figure 8 presents a set of rules for pre-access analysis, the technique of access and orifice location, and the laws of centrality, concentricity, color change, symmetry, orifice location, and floor anatomy regarding the qualification of teeth for endodontic treatment based on the analysis of the anatomy of the treated tooth and the surrounding tissues [95][96][97]. Radiographic and CBCT studies are used to measure the distance between the furcation and the cusp tip and the cusp tip-pulp floor distance CPFD to prevent chamber perforation in the furcation [98]. A root canal requires preparation, followed by apically, laterally, and coronally sealing by obturation to prevent the spread of bacteria and possible toxins from the root canal towards the root apex [99][100][101] and also from saliva [102]. Progress in the field of endodontics has been taking place in the world since 1836 when E. Maynard removed the pulp from the inside of the tooth for the first time [103]. Techniques for the development and obturation of root canals are systematically developed [97], although the pace of these A root canal requires preparation, followed by apically, laterally, and coronally sealing by obturation to prevent the spread of bacteria and possible toxins from the root canal towards the root apex [99][100][101] and also from saliva [102]. Progress in the field of endodontics has been taking place in the world since 1836 when E. Maynard removed the pulp from the inside of the tooth for the first time [103]. Techniques for the development and obturation of root canals are systematically developed [97], although the pace of these changes is not significant, and the changes have been noticeable over the last half-century. It should be noted that significant progress was made possible by introducing rotating tools to prepare root canals, and very significant progress was achieved by introducing Nitinol tools into endodontic practice after the end of the 20th century [104]. The publication mentioned above [104] comprehensively analyzes this problem; therefore, this paper does not broadly develop this problem. Nitinol, as an alloy of nickel and titanium with equilibrium or strongly similar to atomic balance concentration of both of these elements with a very high metallurgical purity and produced by vacuum smelting, shows the effect of superelasticity and shape memory, thanks to which it allows drilling in strongly curved root canals without fear of breaking the tool, enabling the prevention of the strong iatrogenic complications associated with it [104]. The importance of Nitinol in endodontics is also confirmed by numerous practical experiences and studies of specific tools made of this material performed by dentists, presented, e.g., in the works [105,106].
Some of these changes may be of historical importance now but are generally illustrated as an umbrella for endodontic development and obturation methods [86] (Figure 9a). Among these methods, the diagram of the most modern Thermo-Hydraulic Condensation technique [107][108][109][110] was presented in detail, filling root canals with the use of System B, introduced about 20 years ago, enabling the lateral canals to be filled to a greater extent and consisting of increasing the plasticity time of such filling materials as, e.g., based on gutta-percha or resilon, under the influence of temperature and pressure generated during this procedure, by the use of appropriate equipment (Figure 9b-j). For analyzing the conditions for the development of root canals and obturation methods, the so-called "Digital twins" as an approach appropriate for Industry 4.0  and the resulting idea of Dentistry 4.0 could be used [145][146][147]. It is possible to perform experiments in virtual space and theoretical analysis with methods usually used in management science, and especially in foresight research as part of knowledge management.
One of the criteria for the effectiveness of the development and obturation of root For analyzing the conditions for the development of root canals and obturation methods, the so-called "Digital twins" as an approach appropriate for Industry 4.0  and the resulting idea of Dentistry 4.0 could be used [145][146][147]. It is possible to perform experiments in virtual space and theoretical analysis with methods usually used in management science, and especially in foresight research as part of knowledge management.
One of the criteria for the effectiveness of the development and obturation of root canals is the quality and tightness of the root canal filling, for which the materials engineering research apparatus and the achievement of technological foresight of surface engineering were used. The virtual analysis used, among other things, the methodology of procedural benchmarking and comparative analysis with the use of contextual matrices, as tools often used previously by the authors of this article, including for the assessment of surface engineering technology [115,[148][149][150][151][152][153][154][155][156][157][158][159][160][161][162][163][164][165], as well as dental issues [71,92,96,97].
Criteria for the multi-criteria evaluation of generalized indices characterizing the potential and attractiveness of both methods of elaboration and obturation of root canals were defined (Figures 10 and 11) [92].
Each of the criteria was assigned weights reflecting their importance; for each set of criteria, they were summed up to one, and then the assessment of these methods according to previously adopted criteria in an appropriately selected scale was made [92]. The basis for both the selection of criteria and assigning them appropriate weights, and above all individual assessment in each criterion, is the use of expert knowledge, which consists of the life and professional experience of experts. It is possible to use the knowledge of at least one expert, which would not be a mistake, while the assessment can be objectified by consulting a large group of experts, provided that each of them is close to the issues assessed.
The numerical rating of each of the methods for the development and obturation of root canals, granted under each of the criteria, should be multiplied by its weight, and then the individual partial results summed up for each set of criteria, thus obtaining a weighted average constituting a tool for comparative analysis. This allows the determination of the significance of a given method of the proper development and obturation of root canals compared to others.
The development of contextual matrices was inspired by the portfolio methods used to characterize the portfolio of products offered to the client by the company, drawing on the prototype developed by the Boston Consulting Group (BCG) [166]. They have become extremely popular in management sciences, where the star and the cash cow are synonymous with the success of dominant market entities; the question mark does not cancel the venture but does not guarantee success, while the dog is a symbol of a failed venture. Using such a selected methodological apparatus, allowing for a comparative analysis of adequately elaborating and obturating root canals, it is also possible to define critical (priority) methods of key importance and/or the best development prospects. Processes 2021, 9, x FOR PEER REVIEW 15 of 44 Figure 10. Contextual matrix of attractiveness of (a) virtual contextual analysis regarding methods of root canal preparation and a set of adopted criteria for expert assessment (b). Figure 10. Contextual matrix of attractiveness of (a) virtual contextual analysis regarding methods of root canal preparation and a set of adopted criteria for expert assessment (b). Processes 2021, 9,    least one expert, which would not be a mistake, while the assessment can be objectified by consulting a large group of experts, provided that each of them is close to the issues assessed. A ten-point unipolar positive interval scale without zero was used, where 10 is the maximum possible rating and 1 is the minimum rating ( Figure 12). This universal scale of relative states has been used so far in many previous studies by the authors of this article [71,92,96,97,115,[148][149][150][151][152][153][154][155][156][157][158][159][160][161][162][163][164][165]. The numerical rating of each of the methods for the development and obturation of root canals, granted under each of the criteria, should be multiplied by its weight, and then the individual partial results summed up for each set of criteria, thus obtaining a weighted average constituting a tool for comparative analysis. This allows the determination of the significance of a given method of the proper development and obturation of root canals compared to others.
The development of contextual matrices was inspired by the portfolio methods used to characterize the portfolio of products offered to the client by the company, drawing on the prototype developed by the Boston Consulting Group (BCG) [166]. They have become extremely popular in management sciences, where the star and the cash cow are synonymous with the success of dominant market entities; the question mark does not cancel the venture but does not guarantee success, while the dog is a symbol of a failed venture. Using such a selected methodological apparatus, allowing for a comparative analysis of adequately elaborating and obturating root canals, it is also possible to define critical (priority) methods of key importance and/or the best development prospects.
Generalized dendrological value matrices of methods and modes, including technologies, make it possible to position these methods and modes depending on their generalized potential and generalized attractiveness. Generalized potential is the real objective value of a given method or mode, while generalized attractiveness reflects its subjective perception among its potential users. The generalized potential of a given group of methods or modes, expressed using the universal scale of relative states, plotted on the horizontal axis of the dendrological matrix, results from a multi-criteria analysis carried out based on expert assessment. It considers appropriate proportions of the generalized potential: creative, applicative, qualitative, developmental, and technical, expressed by an appropriately selected set of criteria, which were assigned appropriate weights. On the vertical axis of the generalized dendrological matrix, the generalized attractiveness of a given group of methods and modes was plotted, being the weighted average of expert assessment made based on detailed criteria corresponding to economic, market, humanistic, natural, and natural systemic attractiveness.
Based on the expert analyses [92], Figure 13 show the criteria for evaluation of the research material depending on the variants of development and obturation of the root canal.
Depending on the value of the generalized potential and the level of generalized attractiveness, which were determined within the expert assessment [92], each of the analyzed methods or modes was placed in one of the matrix quarters distinguished in the generalized dendrological matrix. Depending on the location of each of the analyzed methods or modes in a given quadrant, one can conclude about their market or methodological success, respectively, as in the discussed case concerning endodontics. Methods or modes with high generalized potential from the range (5.5; 10) and high generalized attractiveness from the field (5.5; 10) are located in the quarter of the wide-stretching oak. This can ensure the future success and expansion, for example, of the market expansion of particular methods and modes used in endodontics. There is no method of treating root canals in this quadrant, but there are four obturation methods, i.e., the Thermo-Hydraulic Condensation technique, hot side condensation, and the thermomechanical condensation gutta-percha plasticized method. In the quadrant dwarf rooted mountain pine, where the generalized potential is large in the range (5.5; 10), with limited generalized attractiveness in the field (1; 5.5), success is highly probable but subject to additional commitment to improving attractiveness. In this quadrant, there is a method of rotating machining using tools made of a Nitinol alloy, and in the area of obturation, the central stud method. There are methods or modes with high generalized attractiveness in the range (5.5; 10) in the soaring cypress quarter, but with limited generalized potential in the range (1; 5.5). Because, in such a case, the advantages are apparent and could obscure the real application possibilities, therefore success cannot be ruled out; although it is possible, it is not certain. In this quadrant, among the methods of root canal preparation, there is mechanical treatment with the use of steel tools, while in the field of obturation, there is the cold side condensation method. The quadrant quaking aspen, where both the generalized potential and generalized attractiveness are in the range (1; 5.5), indicates the weakest methods or modes that indicate the need to abandon their practical application, as they will not ensure success. The methods completely disqualified in root canal preparation include laser and ultrasonic treatment. In contrast, in the field of obturation methods, the use of pastes for filling root canals should be included. The results of virtual analyses [92] obtained in this way indicate a limited range of possibilities for the development and obturation of root canals under practical conditions. Processes 2021, 9, x FOR PEER REVIEW 18 of 44 perception among its potential users. The generalized potential of a given group of methods or modes, expressed using the universal scale of relative states, plotted on the horizontal axis of the dendrological matrix, results from a multi-criteria analysis carried out based on expert assessment. It considers appropriate proportions of the generalized potential: creative, applicative, qualitative, developmental, and technical, expressed by an appropriately selected set of criteria, which were assigned appropriate weights. On the vertical axis of the generalized dendrological matrix, the generalized attractiveness of a given group of methods and modes was plotted, being the weighted average of expert assessment made based on detailed criteria corresponding to economic, market, humanistic, natural, and natural systemic attractiveness. Based on the expert analyses [92], Figure 13 show the criteria for evaluation of the research material depending on the variants of development and obturation of the root canal. Depending on the value of the generalized potential and the level of generalized attractiveness, which were determined within the expert assessment [92], each of the analyzed methods or modes was placed in one of the matrix quarters distinguished in the generalized dendrological matrix. Depending on the location of each of the analyzed methods or modes in a given quadrant, one can conclude about their market or methodological success, respectively, as in the discussed case concerning endodontics. Methods or modes with high generalized potential from the range (5.5; 10) and high generalized attractiveness from the field (5.5; 10) are located in the quarter of the wide-stretching oak. This can ensure the future success and expansion, for example, of the market expansion of particular methods and modes used in endodontics. There is no method of treating root canals in this quadrant, but there are four obturation methods, i.e., the Thermo-Hydraulic Condensation technique, hot side condensation, and the thermomechanical condensation gutta-percha plasticized method. In the quadrant dwarf rooted mountain pine, where the generalized potential is large in the range (5.5; 10), with limited generalized attractiveness There are essential factors that determine the correctness of endodontic treatment. The preparation of the root canal presented above depends not only on the dentist's experience but also on selecting tools. The second factor is also the technique of obturation discussed above, which depends mainly on the experience and skills of the dentist. Endodontic treatment is based on the optimal use of the filling material, ensuring the best sealing of the root canal with an appropriately given and required shape after removing the contents inside it and after its careful disinfection.
As experiments have shown, endodontics' goal is only "asymptotic" and hypothetic to produce a monoblock as a solid, bonded, continuous dentin material from one root canal wall to another, usually mechanically forming a homogeneous unit with the root dentin [177]. A strong connection of the monoblock elements with the reinforcing material is required, and the modulus of elasticity of the monoblock and this material should have similar values [178]. There are three types of monoblocks depending on the number of interfaces between the bulk material core and the binding substrate. The primary monoblock shows a single interface between the material and the root canal wall, as in the case of Hydron [179], MTA mineral trioxide aggregate [180,181], bio-gutta, and polyethene fiber core systems [97]. The secondary monoblock has two points of contact, between the core material and the cement, and the other between the cement and dentin, as in the case of gutta-percha-based filling materials due to the presence of a sealant [182], despite a too low modulus of elasticity [183][184][185], and adhesives as substitutes for gutta-percha [186], as well as resilon with a methacrylate-based sealant, although strong polymerization shrinkage causes leaks [168] and makes the monoblock's existence impossible. Tertiary monoblocks have a third boundary between the filler material and the bonding medium such as EndoRez or resin-coated gutta-percha with CLEARFIL LINER BOND 2V binder [187,188] or using ActiV GP [187,189]. It was generally shown in [190,191] that the monoblock concept is not true, despite its stable position in the literature. Schematically, the monoblock concept is presented in Figure 14.

Material for Research and Scope of Experimental Research
The main factor determining the effectiveness of endodontic filling is the selection of filling material and an adequate obturation method. According to the program described in detail in the works [36,96,97], the published detailed results of studies conducted separately for various materials were used. Eighty human teeth extracted for medical indications but not affected by caries were selected for the study. Among them, five groups of 16 teeth were distinguished [92].
Root canals were prepared with hand tools (ProTaper-Dentsply/Maillefer) and alternatively in appropriate groups with K3 rotary tools (Sybron Endo) using the X-Smart endodontic micromotor (DentSply/Maillefer) with each root canal recapitulation using the Keer tool. During the mechanical preparation of the root canals, a RC-Prep lubricant (Premier) containing glycerin, sodium edetate, and urea peroxide was used, and irrigation was performed alternately with 2.25% sodium hypochlorite solution and 0.9% saline solution between the subsequent insertion of the instruments into the root canal.
After processing, the examined teeth were filled with material based on gutta-percha (three groups) and resilon (two groups) by cold side condensation and thermoplastic using the Thermo-Hydraulic Condensation technique using a Buchanan plugger (SybronEndo) and an Obtura III type system (SybronEndo) fixed at 160 °C. In the case of the material based on gutta-percha, a thermoplastic method was also used to use a Ther-

Material for Research and Scope of Experimental Research
The main factor determining the effectiveness of endodontic filling is the selection of filling material and an adequate obturation method. According to the program described in detail in the works [36,96,97], the published detailed results of studies conducted separately for various materials were used. Eighty human teeth extracted for medical indications but not affected by caries were selected for the study. Among them, five groups of 16 teeth were distinguished [92].
Root canals were prepared with hand tools (ProTaper-Dentsply/Maillefer) and alternatively in appropriate groups with K3 rotary tools (Sybron Endo) using the X-Smart endodontic micromotor (DentSply/Maillefer) with each root canal recapitulation using the Keer tool. During the mechanical preparation of the root canals, a RC-Prep lubricant (Premier) containing glycerin, sodium edetate, and urea peroxide was used, and irrigation was performed alternately with 2.25% sodium hypochlorite solution and 0.9% saline solution between the subsequent insertion of the instruments into the root canal.
After processing, the examined teeth were filled with material based on gutta-percha (three groups) and resilon (two groups) by cold side condensation and thermoplastic using the Thermo-Hydraulic Condensation technique using a Buchanan plugger (SybronEndo) and an Obtura III type system (SybronEndo) fixed at 160 • C. In the case of the material based on gutta-percha, a thermoplastic method was also used to use a Thermafil system with the ThermaPrep Plus furnace and a Therma-Cut drill without water cooling at a speed of 300,000 rpm. After filling them with filling material, the mouths of the root canals were secured with Ketac Molar glass-ionomer cement (3M ESPE), and the teeth were stored for seven days at room temperature and wrapped with gauze soaked in physiological saline in a sealed container.
The gutta-percha-based filling material used in the research is used in endodontics in the form of studs or pellets, in which the pure β form of gutta-percha constitutes 18-22%, and the rest is a mixture of 59-75% zinc oxide, which improves plasticity and reduces brittleness, 1.1-31.2% of barium and strontium sulfate, ensuring X-ray impermeability and therefore the possibility of identification with this method, as well as 1-4.1% of other polymers and wax [36]. Gutta-percha studs and pellets (DentSply/Maillefer) and AH Plus sealant (DentSply/Maillefer) from Dentsply Maillefer, Ballaigues, Switzerland were used.
Synthetic filler material based on polyester materials consists of an organic part constituting a matrix of methacrylate resin and about 65% of inorganic fillers, including bioactive glass, barium sulfate, and bismuth oxychloride impermeable to X-rays [192][193][194][195][196][197][198]. This material was first introduced by Resilon Research, LLC, Madison, CT, USA [193], and hence it is mainly known under the trade name resilon. The system also includes a dual-curing resin sealant containing about 70% calcium hydroxide, bismuth oxychloride, barium glass and silica filler, and a self-etching primer containing sulfonic acid-terminated functional monomer, HEMA 2-hydroxyelylmethacrylate, water, and a polymerization initiator [191,192,199,200]. RealSeal resilon studs and pellets (SybroEndo) from Sybron Dental Specialties, Orange, CA, USA and RealSeal sealant known as epiphany from Pentron Clinical Technologies, Wallingford, CT, USA were used.
After obturation and filling with filling material, the teeth were incised with a diamond disc on one side along the root, to a depth of 1 mm, using a prosthetic handpiece. After immersion in liquid nitrogen, a longitudinal fracture was made. Each sample was sputtered with a thin layer of gold in a BAL-TEC SCD050 sputtering machine by Oerlikon Balzers to prepare for materialographic examinations in a scanning electron microscope. Preparations for testing were also made by decalcifying for 14 days in an aqueous solution containing 7% formic acid, 3% hydrochloric acid, and 8% sodium citrate, and after rinsing under running water, they were immersed for 12 h and rinsed in 99% acetic acid. The samples were then rinsed with distilled water and dehydrated each time for 30 min in an aqueous solution of successively increasing concentrations of 25, 50, 70, 90, 95, and 100% ethanol to be subsequently stored in methyl salicylate.
To assess the tightness of root canal filling using materials based on gutta-percha and resilon, attention was paid to seven elements of the research material evaluation depending on root canal preparation and obturation ( Figure 15) [92].
The choice of the appropriate method for assessing tightness and the other aspects mentioned above in evaluating the research material are depending on the variants of development and obturation of the root canal. In work [92], an analysis of the weighted scoring method was carried out with the development of the "meteorologi-cal" contextual attractiveness matrix, which showed that among the methods of as-sessing tightness of root canal fillings, the highest values and a clear advantage over other methods in terms of effectiveness were given to visualization methods using materialographic microscopes ( Figure 10). Processes 2021, 9, x FOR PEER REVIEW 22 of 44 Figure 15. Contextual matrix of attractiveness (a) of the virtual contextual analysis regarding the selection of methods for assessing tightness of the root canal filling and a set of adopted criteria for expert assessment (b). Figure 15. Contextual matrix of attractiveness (a) of the virtual contextual analysis regarding the selection of methods for assessing tightness of the root canal filling and a set of adopted criteria for expert assessment (b).
These methods make it possible to obtain the required high resolution, ensuring the disclosure of structural details and the measurement of the changes that occur, as well as the location of the sealant and filling material in the root canal. It applies in particular to research with the use of all available materialographic microscopes, imainly the ZEISS LSM Stereo Discovery.V12 automated stereoscopic light microscope with the HRC camera and the SEM SUPRA 35 high-resolution scanning electron mi-croscope from ZEISS with the WDS, EDS spectrometer, and the EBSD TRIDENT cam-era. XM4 by EDAX. Therefore, the basic research discussed in this article was per-formed using methods appropriate for materialographic research [96,97]. These tests were performed in LSM with magnification up to 50× and in SEM in the range of mag-nifications up to 5000×. The results of the research were digitally archived. Using SEM, measurements of the width of the slits were also made, and the results of these meas-urements were statistically processed, giving the mean value and standard deviation and analyzing the significance of the mean difference.
The results of the SWOT point analysis (strengths and weaknesses, opportunities, threats) were also compared, according to the previously described methodology and the results of analyzes contained in the works [96,97], each time defining five key fac-tors relating to each aspect in this analysis, adequate to both analyzed filling materials. A contextual dendrological matrix, taken from the work [92] on endodontic filling materials, is also presented. The generalized dendrological matrix of filling materials used in endodontics is presented in the coordinate system generalized potential show-ing the real objective value of a given material-generalized attractiveness of these materials for endodontic treatment.

Tightness of Root Canal Filling with Filling Materials Based on Gutta-Percha and Resilon
In the stereoscopic light microscope, preliminary studies of the longitudinal fractures of the teeth filled with material based on gutta-percha ( Figure 16G) and resilon ( Figure 16R), respectively, were carried out, indicating that the root canal is tightly filled by the main stud connected to the root canal dentin with a relatively thick-or thin-layer intermediate sealant.
scoring method was carried out with the development of the "meteorologi-cal" contextual attractiveness matrix, which showed that among the methods of as-sessing tightness of root canal fillings, the highest values and a clear advantage over other methods in terms of effectiveness were given to visualization methods using materialographic microscopes ( Figure 10).
These methods make it possible to obtain the required high resolution, ensuring the disclosure of structural details and the measurement of the changes that occur, as well as the location of the sealant and filling material in the root canal. It applies in particular to research with the use of all available materialographic microscopes, imainly the ZEISS LSM Stereo Discovery.V12 automated stereoscopic light microscope with the HRC camera and the SEM SUPRA 35 high-resolution scanning electron mi-croscope from ZEISS with the WDS, EDS spectrometer, and the EBSD TRIDENT cam-era. XM4 by EDAX. Therefore, the basic research discussed in this article was per-formed using methods appropriate for materialographic research [96,97]. These tests were performed in LSM with magnification up to 50× and in SEM in the range of mag-nifications up to 5000×. The results of the research were digitally archived. Using SEM, measurements of the width of the slits were also made, and the results of these meas-urements were statistically processed, giving the mean value and standard deviation and analyzing the significance of the mean difference.
The results of the SWOT point analysis (strengths and weaknesses, opportunities, threats) were also compared, according to the previously described methodology and the results of analyzes contained in the works [96,97], each time defining five key fac-tors relating to each aspect in this analysis, adequate to both analyzed filling materials. A contextual dendrological matrix, taken from the work [92] on endodontic filling materials, is also presented. The generalized dendrological matrix of filling materials used in endodontics is presented in the coordinate system generalized potential show-ing the real objective value of a given material-generalized attractiveness of these materials for endodontic treatment.

Tightness of Root Canal Filling with Filling Materials Based on Gutta-Percha and Resilon
In the stereoscopic light microscope, preliminary studies of the longitudinal fractures of the teeth filled with material based on gutta-percha ( Figure 16G) and resilon ( Figure  16R), respectively, were carried out, indicating that the root canal is tightly filled by the main stud connected to the root canal dentin with a relatively thick-or thin-layer intermediate sealant.  Thanks to scanning electron microscopy, dentinal tubules' presence was revealed as the effectiveness of the endodontic treatment of teeth. The correct choice of filling material is significantly influenced by both the technology of root canal development and the obturation sealing materials used. These factors determine the quality of the root canal filling and the quality of the connection of the main stud of the filling material with the supplementary material.
In the cold obturation technique, the proportion of sealant tightly covering the filling material is relatively high, both when using a material based on gutta-percha and resilon ( Figure 17). The sealant is used to fix the main stud and additional studs together. The sealant must surround the studs of the filling material on all sides. Local shortages of the Processes 2021, 9,2014 23 of 42 sealant cause local non-adhesion of the material and leakages that significantly reduce the quality of endodontic treatment. The desired uniform filling encapsulating the root canal of any shape requires the correct connection of the central stud with additional studs. These studs are mechanically connected due to condensation and chemically bonded by a sealant. turation sealing materials used. These factors determine the quality of the root canal filling and the quality of the connection of the main stud of the filling material with the supplementary material.
In the cold obturation technique, the proportion of sealant tightly covering the filling material is relatively high, both when using a material based on gutta-percha and resilon ( Figure 17). The sealant is used to fix the main stud and additional studs together. The sealant must surround the studs of the filling material on all sides. Local shortages of the sealant cause local non-adhesion of the material and leakages that significantly reduce the quality of endodontic treatment. The desired uniform filling encapsulating the root canal of any shape requires the correct connection of the central stud with additional studs. These studs are mechanically connected due to condensation and chemically bonded by a sealant. Unfavorable non-connection of the material occurs ( Figure 18) if the sealant is present between the main stud and the additional studs. This effect is more often observed when resilon is used as a filling material than in the case of using a material based on guttapercha. Similar effects of the delamination and separation of the filling material from the dentin of the root canal and the resulting leaks may be caused by an excessively thick layer of sealant, and therefore its share is too high.  Unfavorable non-connection of the material occurs ( Figure 18) if the sealant is present between the main stud and the additional studs. This effect is more often observed when resilon is used as a filling material than in the case of using a material based on gutta-percha. Similar effects of the delamination and separation of the filling material from the dentin of the root canal and the resulting leaks may be caused by an excessively thick layer of sealant, and therefore its share is too high. turation sealing materials used. These factors determine the quality of the root canal filling and the quality of the connection of the main stud of the filling material with the supplementary material.
In the cold obturation technique, the proportion of sealant tightly covering the filling material is relatively high, both when using a material based on gutta-percha and resilon ( Figure 17). The sealant is used to fix the main stud and additional studs together. The sealant must surround the studs of the filling material on all sides. Local shortages of the sealant cause local non-adhesion of the material and leakages that significantly reduce the quality of endodontic treatment. The desired uniform filling encapsulating the root canal of any shape requires the correct connection of the central stud with additional studs. These studs are mechanically connected due to condensation and chemically bonded by a sealant. Unfavorable non-connection of the material occurs ( Figure 18) if the sealant is present between the main stud and the additional studs. This effect is more often observed when resilon is used as a filling material than in the case of using a material based on guttapercha. Similar effects of the delamination and separation of the filling material from the dentin of the root canal and the resulting leaks may be caused by an excessively thick layer of sealant, and therefore its share is too high.  Thanks to the scanning electron microscope tests, the presence of dentinal tubules was revealed as the smallest anatomical structures in teeth's longitudinal or transverse sections, respectively. The tightness of the connection of the filling material with the dentin of the root canal after obturation using the cold lateral condensation method was demonstrated. The disinfection of the internal space was confirmed, and the tight, three-dimensional hermetization was manifested by the correct combination of dentin and filling material based on gutta-percha or resilon, respectively, with a thin intermediate layer of sealant, closely adjacent to the border of the root canal wall (Figure 19).
Thanks to the scanning electron microscope tests, the presence of dentinal tubules was revealed as the smallest anatomical structures in teeth's longitudinal or transverse sections, respectively. The tightness of the connection of the filling material with the dentin of the root canal after obturation using the cold lateral condensation method was demonstrated. The disinfection of the internal space was confirmed, and the tight, threedimensional hermetization was manifested by the correct combination of dentin and filling material based on gutta-percha or resilon, respectively, with a thin intermediate layer of sealant, closely adjacent to the border of the root canal wall (Figure 19). The quality of the connection of the filling material with the dentin of the root canal, in fact, determines the tightness of the root canal filling and the related tightness of the filling, and in practice, the low surface density of the leaks and their small size. In both compared filling materials, despite their tight filling, there is no penetration of sealant particles into the dental tubules. Thus, cold condensation makes the three-dimensional obturation of the root canal and the penetration of filling material and sealant into depressions and niches that may appear along the entire length of the root canal impossible (Figure 20).  The quality of the connection of the filling material with the dentin of the root canal, in fact, determines the tightness of the root canal filling and the related tightness of the filling, and in practice, the low surface density of the leaks and their small size. In both compared filling materials, despite their tight filling, there is no penetration of sealant particles into the dental tubules. Thus, cold condensation makes the three-dimensional obturation of the root canal and the penetration of filling material and sealant into depressions and niches that may appear along the entire length of the root canal impossible (Figure 20).
Thanks to the scanning electron microscope tests, the presence of dentinal tubules was revealed as the smallest anatomical structures in teeth's longitudinal or transverse sections, respectively. The tightness of the connection of the filling material with the dentin of the root canal after obturation using the cold lateral condensation method was demonstrated. The disinfection of the internal space was confirmed, and the tight, threedimensional hermetization was manifested by the correct combination of dentin and filling material based on gutta-percha or resilon, respectively, with a thin intermediate layer of sealant, closely adjacent to the border of the root canal wall (Figure 19). The quality of the connection of the filling material with the dentin of the root canal, in fact, determines the tightness of the root canal filling and the related tightness of the filling, and in practice, the low surface density of the leaks and their small size. In both compared filling materials, despite their tight filling, there is no penetration of sealant particles into the dental tubules. Thus, cold condensation makes the three-dimensional obturation of the root canal and the penetration of filling material and sealant into depressions and niches that may appear along the entire length of the root canal impossible (Figure 20). Hot root canal obturation by thermoplastic condensation using the Thermo-Hydraulic Condensation (THC) technique [105][106][107][108][109][110] ensures tight and desirable adherence of the filling material, regardless of whether it is based on gutta-percha or resilon, covered with an appropriate uniform intermediate layer of root dentin sealant in each of the assessed Figure 20. Connection of the dentin of the root canal with the visible dentin tubules after cold lateral condensation after filling the root canal with a material based on gutta-percha (G) and resilon (R) covered with sealant; SEM.
Hot root canal obturation by thermoplastic condensation using the Thermo-Hydraulic Condensation (THC) technique [105][106][107][108][109][110] ensures tight and desirable adherence of the filling material, regardless of whether it is based on gutta-percha or resilon, covered with an appropriate uniform intermediate layer of root dentin sealant in each of the assessed sections of the root canal (Figure 21), which was confirmed by the results of scanning electron microscopy tests.
The tight connection of the two compared filling materials, evenly covered with the intermediate layer of the sealant, with the root canal dentin is ensured by thermoplastic application of the hot filling material using the THC technique [96,97]. Especially when resilon is used, the filling material is applied to the root canal by dividing it into three or four parts, between the application of which there is a vertical condensation of the material during its cooling. In this case, when joining two different parts of the filling material, correct vertical condensation occurs as the individual sections are pressed against each other by a cold piston. This minimizes the polymerization shrinkage of the filler material studs, which is particularly important when resilon is used. Obturation performed in this way prevents leaks at the boundary of the filling material covered with a thin layer of sealant and the root canal wall. Under these conditions, the sealant adheres closely to the root dentin in the root canal ( Figure 22). sections of the root canal (Figure 21), which was confirmed by the results of scanning electron microscopy tests. The tight connection of the two compared filling materials, evenly covered with the intermediate layer of the sealant, with the root canal dentin is ensured by thermoplastic application of the hot filling material using the THC technique [96,97]. Especially when resilon is used, the filling material is applied to the root canal by dividing it into three or four parts, between the application of which there is a vertical condensation of the material during its cooling. In this case, when joining two different parts of the filling material, correct vertical condensation occurs as the individual sections are pressed against each other by a cold piston. This minimizes the polymerization shrinkage of the filler material studs, which is particularly important when resilon is used. Obturation performed in this way prevents leaks at the boundary of the filling material covered with a thin layer of sealant and the root canal wall. Under these conditions, the sealant adheres closely to the root dentin in the root canal ( Figure 22). Despite the controversies presented earlier [180,181], it could be concluded that the tight connection of the sealant with the canal dentin after hot obturation with the thermoplastic THC technique, regardless of the filling material used among the two compared (Figures 23 and 24), corresponds to the concept of tertiary monoblock [187][188][189]. The mouths of the dental tubules are closed with sealant flakes, and the filling material adheres closely to the root canal wall [96,97].  The tight connection of the two compared filling materials, evenly covered with the intermediate layer of the sealant, with the root canal dentin is ensured by thermoplastic application of the hot filling material using the THC technique [96,97]. Especially when resilon is used, the filling material is applied to the root canal by dividing it into three or four parts, between the application of which there is a vertical condensation of the material during its cooling. In this case, when joining two different parts of the filling material, correct vertical condensation occurs as the individual sections are pressed against each other by a cold piston. This minimizes the polymerization shrinkage of the filler material studs, which is particularly important when resilon is used. Obturation performed in this way prevents leaks at the boundary of the filling material covered with a thin layer of sealant and the root canal wall. Under these conditions, the sealant adheres closely to the root dentin in the root canal ( Figure 22). Despite the controversies presented earlier [180,181], it could be concluded that the tight connection of the sealant with the canal dentin after hot obturation with the thermoplastic THC technique, regardless of the filling material used among the two compared ( Figures 23 and 24), corresponds to the concept of tertiary monoblock [187][188][189]. The mouths of the dental tubules are closed with sealant flakes, and the filling material adheres closely to the root canal wall [96,97]. Despite the controversies presented earlier [180,181], it could be concluded that the tight connection of the sealant with the canal dentin after hot obturation with the thermoplastic THC technique, regardless of the filling material used among the two compared ( Figures 23 and 24), corresponds to the concept of tertiary monoblock [187][188][189]. The mouths of the dental tubules are closed with sealant flakes, and the filling material adheres closely to the root canal wall [96,97].   The structure of the connection of the root dentin with the filling material using hot thermoplastic condensation using the THC technique, covered with a thin interlayer of the sealant with its fine-flake structure and the cross-section of the tooth tubules along their axis transverse to the root canal axis after obturation with a gutta-percha-based material (G) and resilon (R); SEM. Using a filling material based on gutta-percha, a tight three-layer connection of the root dentin filling material takes place with the participation of a sealant interlayer, the flake structure of which allows it to close the dentinal tubules ( Figure 24). The analysis of the filling of the dentinal tubules by the sealant in the apical, medial, and coronary sections shows that this penetration is statistically shallower in the apical area than in the remaining sections of the root canal.
Both methods of thermoplastic hot obturation using the THC technique applied to the filling material based on gutta-percha and resilon, and the Thermafil methods applied to the filling material based on gutta-percha, require a much lower proportion of the sealant compared to the actual filling material in the root canal, compared to the method of cold obturation on the root canal ( Figure 25). There is often a tight monoblock of dentin, sealant, and main filling material, despite claims contested this concept [190,191]. The chance of minimizing polymerization shrinkage increases because the application of the material to the root canal is divided into three or four parts, between which there is a sealant. As a result of dividing the application of the main stud, when resilon is used, the polymerization shrinkage is also reduced, which also reduces the proportion of sealant and lack of leaks at the boundary of the filling material and the root canal wall ( Figure 25). Conversely, when the Thermafil obturator is used, there is a significant build-up of sealant Using a filling material based on gutta-percha, a tight three-layer connection of the root dentin filling material takes place with the participation of a sealant interlayer, the flake structure of which allows it to close the dentinal tubules ( Figure 24). The analysis of the filling of the dentinal tubules by the sealant in the apical, medial, and coronary sections shows that this penetration is statistically shallower in the apical area than in the remaining sections of the root canal.
Both methods of thermoplastic hot obturation using the THC technique applied to the filling material based on gutta-percha and resilon, and the Thermafil methods applied to the filling material based on gutta-percha, require a much lower proportion of the sealant compared to the actual filling material in the root canal, compared to the method of cold obturation on the root canal ( Figure 25). There is often a tight monoblock of dentin, sealant, and main filling material, despite claims contested this concept [190,191]. The chance of minimizing polymerization shrinkage increases because the application of the material to the root canal is divided into three or four parts, between which there is a sealant. As a result of dividing the application of the main stud, when resilon is used, the polymerization shrinkage is also reduced, which also reduces the proportion of sealant and lack of leaks at the boundary of the filling material and the root canal wall ( Figure 25). Conversely, when the Thermafil obturator is used, there is a significant build-up of sealant in the periapical area, caused by the apical movement of the sealant by the obturator pressing against the less sticky components.
Processes 2021, 9, x FOR PEER REVIEW 28 of 44 in the periapical area, caused by the apical movement of the sealant by the obturator pressing against the less sticky components. The tight connection of the sealant with the canal dentin after hot obturation with the thermoplastic THC technique is demonstrated by the AH Plus sealant based on synthetic resins, which can be used regardless of the technique of obturation with gutta-perchabased material. Due to the fine-particle structure, this sealant is characterized by the ability to penetrate deep into the dentinal tubules. As a result of THC obturation, not only the The tight connection of the sealant with the canal dentin after hot obturation with the thermoplastic THC technique is demonstrated by the AH Plus sealant based on synthetic resins, which can be used regardless of the technique of obturation with gutta-percha-based material. Due to the fine-particle structure, this sealant is characterized by the ability to penetrate deep into the dentinal tubules. As a result of THC obturation, not only the sealant but also the filling material penetrates the dentinal tubules. In this respect, the material based on gutta-percha shows slightly better properties than resilon ( Figure 26). The tight connection of the sealant with the canal dentin after hot obturation with the thermoplastic THC technique is demonstrated by the AH Plus sealant based on synthetic resins, which can be used regardless of the technique of obturation with gutta-perchabased material. Due to the fine-particle structure, this sealant is characterized by the ability to penetrate deep into the dentinal tubules. As a result of THC obturation, not only the sealant but also the filling material penetrates the dentinal tubules. In this respect, the material based on gutta-percha shows slightly better properties than resilon ( Figure 26). The obturation technique has a decisive impact on the possibility of providing threedimensional obturation of the root canal with filling its additional structures [86,87]. In the cold obturation method, only the sealant fills the root delta and lateral canals, while in the thermoplastic method, the root delta and lateral canals are, in turn, filled with both the sealant and the filling material, mainly when a gutta-perch-based filling material is used on the base of gutta-percha. Both thermoplastic methods, THC and Thermafil, applied to the filling material based on gutta-percha provide three-dimensional obturation of the root canal with filling its additional structures [86].
In the case of the THC thermoplastic method with the use of System B and Obtura III with gutta-percha as the filling material, the side canals, especially in the delta zone of the root canal, are filled with material based on gutta-percha concentrically in relation to the central canal, while at the same time there is a centrifugal filling with sealant in relation The obturation technique has a decisive impact on the possibility of providing threedimensional obturation of the root canal with filling its additional structures [86,87]. In the cold obturation method, only the sealant fills the root delta and lateral canals, while in the thermoplastic method, the root delta and lateral canals are, in turn, filled with both the sealant and the filling material, mainly when a gutta-perch-based filling material is used on the base of gutta-percha. Both thermoplastic methods, THC and Thermafil, applied to the filling material based on gutta-percha provide three-dimensional obturation of the root canal with filling its additional structures [86].
In the case of the THC thermoplastic method with the use of System B and Obtura III with gutta-percha as the filling material, the side canals, especially in the delta zone of the root canal, are filled with material based on gutta-percha concentrically in relation to the central canal, while at the same time there is a centrifugal filling with sealant in relation to the main canal ( Figure 27). At the same time, the closer the root canal is to the coronary part, the more likely it will be filled with gutta-percha-based material in both thermoplastic methods [86,87]. As one approaches the apical region, the tubules are filled with sealant centrifugally to the root canal and concentrically filled with gutta-percha-based material. Directly at the apex, the side canals are filled only with sealant. to the main canal ( Figure 27). At the same time, the closer the root canal is to the coronary part, the more likely it will be filled with gutta-percha-based material in both thermoplastic methods [86,87]. As one approaches the apical region, the tubules are filled with sealant centrifugally to the root canal and concentrically filled with gutta-percha-based material. Directly at the apex, the side canals are filled only with sealant. Even in the case of tight obturation of the root canal using the THC technique, both with the use of gutta-percha-based filling material and resilon, there are gaps between the root dentin and the filling material covered with a sealant (Figure 28). Even in the case of tight obturation of the root canal using the THC technique, both with the use of gutta-percha-based filling material and resilon, there are gaps between the root dentin and the filling material covered with a sealant (Figure 28). Figure 27. The structure of filling the delta zone of the root canal after obturation with the THC technique of hot thermoplastic condensation with the use of a filling material based on gutta-percha (G) in teeth subjected to decalcification with a sealant; LSM.
Even in the case of tight obturation of the root canal using the THC technique, both with the use of gutta-percha-based filling material and resilon, there are gaps between the root dentin and the filling material covered with a sealant (Figure 28). Leaks in the case of obturation using a gutta-percha-based material have a width in the range of 1.061-8.131 μm, while in the case of using resilon they reach 3.535-7.070 μm ( Figure 29). These leaks can occur on the border of the filler material where the sealant and the root dentin have not been found, as well as in the sealant layer itself, closely connected on one side to the root dentin and on the other side to the filler material. Leaks in the case of obturation using a gutta-percha-based material have a width in the range of 1.061-8.131 µm, while in the case of using resilon they reach 3.535-7.070 µm ( Figure 29). These leaks can occur on the border of the filler material where the sealant and the root dentin have not been found, as well as in the sealant layer itself, closely connected on one side to the root dentin and on the other side to the filler material. The preparation and obturation of the root canal using the THC method ensure, along the entire length of the root canal, the average value of the fissure width in the case of material based on gutta-percha 4.76 ± 0.66 μm and in the case of resilon 7.86 ± 1.19 μm. These values differ for individual sections of the root canal. In the case of the coronary section, the mean values of the fissure width are 5.74 ± 0.85 μm for gutta-percha and 8.70 ± 1.56 μm for resilon, respectively. The widths of the fissure in the middle section of the root canal are 4.88 ± 1.02 μm in the case of gutta-percha and 7.96 ± 1.87 μm in the case of resilon. Measurements of the apical section of the root canal indicate that the widths of the gaps are 2.33 ± 0.87 μm in the case of gutta-percha and 2.77 ± 1.83 μm in the case of resilon.
The detailed results of the measurements are presented in Figure 29. The analysis of the significance level of the differences between the widths of the fissures in all analyzed sections for the entire root ( Figure 30) shows that in all sections along the entire length, the differences between the THC method of root canal preparation and obturation and other methods are significant. It means that in this case the best endodontic treatment results are obtained among all the analyzed techniques of preparation and obturation. The preparation and obturation of the root canal using the THC method ensure, along the entire length of the root canal, the average value of the fissure width in the case of material based on gutta-percha 4.76 ± 0.66 µm and in the case of resilon 7.86 ± 1.19 µm. These values differ for individual sections of the root canal. In the case of the coronary section, the mean values of the fissure width are 5.74 ± 0.85 µm for gutta-percha and 8.70 ± 1.56 µm for resilon, respectively. The widths of the fissure in the middle section of the root canal are 4.88 ± 1.02 µm in the case of gutta-percha and 7.96 ± 1.87 µm in the case of resilon. Measurements of the apical section of the root canal indicate that the widths of the gaps are 2.33 ± 0.87 µm in the case of gutta-percha and 2.77 ± 1.83 µm in the case of resilon.
The detailed results of the measurements are presented in Figure 29. The analysis of the significance level of the differences between the widths of the fissures in all analyzed sections for the entire root ( Figure 30) shows that in all sections along the entire length, the differences between the THC method of root canal preparation and obturation and other methods are significant. It means that in this case the best endodontic treatment results are obtained among all the analyzed techniques of preparation and obturation. Similarly, the analysis of the significance of mean differences indicates that the width of the gaps in each case is statistically significantly different, and in each case of using resilon is greater than when using a material based on gutta-percha.
A method consisting of the preparation of root canals with K3 rotary tools (Sybron Endo), up to the size of 40 ISO using the X-Smart endodontic micromotor (DentSply/Maillefer) in two stages, and the filling of the teeth with the THC thermoplastic method using the System B and Obtura III devices (SybronEndo) with studs and pellets made of material based on gutta-percha after covering the root canal walls with a paper filter with a thin layer of AH Plus sealant (DentSply/Maillefer) shows the best results both in terms of the width of the gaps in all analyzed sections and on average for the entire root canal (Figure 30).

Description of the Results of Comparative Analyses Using the Contextual Matrix and SWOT Methods
A comparative analysis was performed using a dendrological context matrix to compare the seven most commonly used materials for filling root canals to close them [92]. On the vertical axis of the dendrological matrix, a generalized index of material strength in the canal is placed, taking into account the strengthening of the root canal and preserving Similarly, the analysis of the significance of mean differences indicates that the width of the gaps in each case is statistically significantly different, and in each case of using resilon is greater than when using a material based on gutta-percha.
A method consisting of the preparation of root canals with K3 rotary tools (Sybron Endo), up to the size of 40 ISO using the X-Smart endodontic micromotor (DentSply/Maillefer) in two stages, and the filling of the teeth with the THC thermoplastic method using the System B and Obtura III devices (SybronEndo) with studs and pellets made of material based on gutta-percha after covering the root canal walls with a paper filter with a thin layer of AH Plus sealant (DentSply/Maillefer) shows the best results both in terms of the width of the gaps in all analyzed sections and on average for the entire root canal ( Figure 30).

Description of the Results of Comparative Analyses Using the Contextual Matrix and SWOT Methods
A comparative analysis was performed using a dendrological context matrix to compare the seven most commonly used materials for filling root canals to close them [92]. On the vertical axis of the dendrological matrix, a generalized index of material strength in the canal is placed, taking into account the strengthening of the root canal and preserving mechanical strength against fracture in combination with the tightness of the filling and its minimum resorption over time.
On the horizontal axis, there is a generalized indicator of the quality of the material in the root canal, related to, e.g., the influence of this material on the patient's body and the possibility of eliminating bacteria from the filled canal. Figure 31 shows the appropriate dendrological matrix and the criteria of mechanical strength influencing the potential root fracture and the quality of root canal filling. The results of the analysis showed that there are no filler materials that would meet all the requirements. The results of the analysis confirmed, however, that only two filling materials, i.e., gutta-percha-based material and resilon, are of real practical importance. The material based on gutta-percha achieved a high score in terms of strength and a relatively high level of filling quality, in contrast to resilon, which has a comparable strength index, but loses on the quality rating.
Based on the results of studies and analyses included, among others in the works [92,96,97], the results of the SWOT point analysis (strengths, weaknesses, opportunities, threats) were used as a method of integrated determination and comparison of the strengths and weaknesses of each of these filling materials based on gutta-percha and resilon, as well as opportunities and threats, that flow for them from the environment. Each time and for each of the compared filler materials, five key internal and external SWOT factors were determined ( Figure 33). These factors are of the greatest importance for the development of the analyzed filling materials, which were assigned weights reflecting their importance. The universal scale of relative states described earlier (Figure 13) was used. Based on each of the criteria factors, the compared materials were assessed by multiplying the awarded expert assessment by the weight assigned to each of the criteria. The sum of the weighted scores was obtained in this way for each group of SWOT factors for each filling material. Thanks to this, it becomes possible to choose a strategy for the individual filling materials used in endodontics to fill root canals. The adopted evaluation criteria take into account the specificity of each of the compared filling materials, and the weights assigned to them are not identical in each of the analyzed cases; therefore, the results of the analyses cannot be compared directly and uncritically. Despite the fact that the scoring of strengths and opportunities is similar for each of the analyzed materials, there are fundamental differences in assessments for both weaknesses and threats. The matrix of possible development strategies for each material may be the only platform for comparing the development prospects of both these filling materials ( Figure 32). Processes 2021, 9, x FOR PEER REVIEW 33 of 44   For obturation using gutta-percha-based material, a multi-criteria SWOT analysis indicates that strengths are rated as (8.30) and (8.65) for obturation with resilon. The weakness rating is (5.70) for obturation with material based on gutta-percha, while if resilon is used, the value is (6.80). In the case of using filling material based on gutta-percha, the opportunities were assessed as (7.45), while when using resilon the opportunities were (7.40). The threats of using a material based on gutta-percha are (6.95), while the environmental threats of resilon correspond to the assessment (8.60) (Figure 33).  The presented data indicate that the situation of each of the analyzed materials is different from that of the other. In the case of a material based on gutta-percha, the weaknesses are significantly smaller than the strengths of this filling material S > W, and at the same time, the threats are slightly lower than the opportunities of O > T. Therefore, the predominance of positive analysis factors, both internal and external, indicates the aggressive MAXI-MAXI strategy as an adequate strategy for the development of gutta-percha-based filling material. With regard to the gutta-percha-based material, full utilization and the resulting market diversification combined with strong market expansion are required. It is highly desirable to search for new customer groups and new geographical outlets.
In the case of resilon, the strategy is quite different. Although the strengths of resilon have a significant advantage over its weaknesses S > W, the opportunities are much smaller than the threats from the environment O < T. In this case, it is only possible to apply the conservative MAXI-MINI strategy of resilon development. Such a strategy requires overcoming considerable environmental threats, with the necessary use of the considerable potential of this filling material. In such a case, a spectacular failure cannot be ruled out, and the state of threat to its development is not eliminated by the possible unexpected success.

Recapitulation of the Problems
The review of the literature contained in this paper was aimed at a comprehensive presentation of the design conditions of engineering filling materials used in endodontics as one of the typical dedicated engineering materials groups and multi-faceted analysis of the conditions of their use and the quality and durability of endodontic fillings made with their participation. This issue is important because, since caries, periodontal disease, and other oral diseases affect 3 to 5 billion people worldwide, and at least 20% of them could be qualified for endodontic treatment, the problem of appropriate material selection arises in each case. It is mainly an engineering problem, although, in the end, every dentist has to face it in relation to each patient, and in the event of a wrong decision made, it can be responsible for a serious ethical tort. It is an original approach, requiring a consistent analysis of the effect of all the component factors. For this analysis, a wide set of methods was used, not only in manufacturing engineering and materials engineering, but also in engineering and knowledge management and technology foresight. Thus, both the scope of the development of manufacturing technologies and engineering materials, taking into account the specificity of dental engineering, and the scope of oral cavity diseases and endodontics within the concept of sustainable dentistry development are presented. Endodontics, which is undoubtedly an interventionist branch of dentistry, fits into its own concept of the Sustainable Development Dentistry (DSD)> 2020 model, consisting of Global Dental Prevention (GDP), Advanced Interventionist Dentistry 4.0 (AID 4.0), and the Dentistry Safety System (DSS). This approach is contrary to the view that there is a need to abandon interventionist treatment in favor of very comprehensive and universal prophylaxis, requiring the egalitarian reach of almost every inhabitant of the globe with dental care. The extent of caries, which covers well over 50% of the world's population, proves that interventionist treatment is an indispensable necessity.
In addition to the data from the literature on these issues, the results of experimental studies are discussed in detail to compare the appropriateness of selecting the most commonly used endodontic filling materials, respectively, based on gutta-percha or polymeric polyester materials, commonly known as resilon. The results of experimental studies with the use of stereoscopic and scanning electron microscopes as well as the results of the SWOT analysis (Strengths-Weaknesses-Opportunities-Threats) and the analysis of the dendrological matrix are presented. It has been shown that due to the possibility of obtaining a sufficiently high resolution with which the examined preparations can be observed, the methods of visualization with the use of materialographic microscopes are the most useful for assessing the effectiveness of in vitro and ex post endodontic treatment methods and techniques. The main factor determining the effectiveness of endodontic filling is the selection of the filling material and the appropriate method of obturation. The tight