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Acute toxicity of flower extracts from Dolichandrone serrulata in mice

Context: Dolichandrone serrulata flowers are widely used as vegetables in northern and eastern Thailand. However, there is no report on the toxicities of this plant. Objective: The present study was aimed to determine the acute toxicity of aqueous flower extracts from D. serrulata in ICR mice. Materials and Methods: The extract at dose of 1000, 1500, and 2000 mg/kg was orally administered once to mice in order to investigate an acute toxicity. Results: The extract did not produce any sign or symptom of toxicity. Dead mouse was not found within the first 24 h and for further 14 days. The body weight increased in comparison to the controls. However, the relative organ weight between the treated and control mice was not different. The hematological values were not altered by the treatment of the extracts. The liver function parameters including aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase among treated mice were not different. The extract did not alter the kidney function parameters (blood urea nitrogen and creatinine). The lipid profiles in treated mice were not changed in comparison to the controls. In addition, histopathological features of the liver and kidney are not altered by the administration of the extracts. Conclusion: The results demonstrated that the maximum dose of D. serrulata flower extracts (2000 mg/kg) does not cause the acute toxicity in male and female mice.