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Impact of Chemotherapy and Radiotherapy on the Survival of Elderly Esophagus Cancer Patients after Surgery: A SEER Database Analysis


 BackgroundEsophagus cancer (EC) is a common and lethal carcinoma, however, the effectiveness and feasibility of the conventional treatments for the elderly patients with surgery have not been discussed fully. The purpose of the current study is to discuss the potential effect of chemotherapy and radiotherapy on the prognosis.ResultsBy PSM, chemotherapy (sHR: 0.588, 95%CI: 0.453-0.763, P<0.001) and radiotherapy (sHR: 0.652, 95%CI: 0.513-0.83, P<0.001) were showed a negative correlation to the probability of cancer specific death (CSD). Based on the nomogram, patients with poor differentiation, large tumor size, advanced T-staging, lymphatic metastasis and distant metastasis tended to benefit from chemotherapy (HR: 0.441, 95%CI: 0.364-0.533, P < 0.001) or radiotherapy (HR: 0.539, 95%CI: 0.448-0.649, P < 0.001) to decrease the probabilities of CSD, while no benefit or even harm was showed among the low-risk ones. ConclusionAggressive treatment such as chemotherapy or radiotherapy was considered effective for the selective elder patients with EC.