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Ion channels in leukocytes.

Abstract : The purpose of this article is to review the ionic channels that have been characterized in leukocytes and, whenever possible, to discuss their functional significance. This review makes no attempt to provide a comprehensive view of ionic transport mechanisms in leukocytes, nor does it attempt to provide an inclusive summary of the numerous studies done using ion-flux techniques and fluorescence measurements that have examined the role of ionic transport in leukocyte function. Rather, it focuses on the electrophysiological evidence for the existence of specific ionic channels in leukocytes, with the exception of the basophil, which is not covered in this review. (Information on the basophil is more appropriately included in a review of mast cells.) Several recent reviews are available for those interested in a discussion of other transport mechanisms in leukocytes.