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Title from Retinal Waves to Activity-dependent Retinogeniculate Map Development Authors and Affiliations Center for Adaptive Systems

*All correspondence should be addressed to 12 Professor Stephen Grossberg 13 Center for Adaptive Systems 14 Boston University 15 677 Beacon Street 16 Boston, MA 02215 17 Email: steve@bu.edu 18 Phone: 617-353-7858/7 19 Fax: 617-353-7755 20 21 Abstract 22 A neural model is described of how spontaneous retinal waves are formed in infant mammals, 23 and how these waves organize activity-dependent development of a topographic map in the 24 lateral geniculate nucleus, with connections from each eye segregated into separate anatomical 25 layers. The model simulates the spontaneous behavior of starburst amacrine cells and retinal 26 ganglion cells during the production of retinal waves during the first few weeks of mammalian 27 postnatal development. It proposes how excitatory and inhibitory mechanisms within individual 28 cells, such as Ca-activated K channels, and cAMP currents and signaling cascades, can 29 modulate the spatiotemporal dynamics of waves, notably by controlling the after30 hyperpolarization currents of starburst amacrine cells. Given the critical role of the geniculate 31 map in the development of visual cortex, these results provide a foundation for analyzing the 32 temporal dynamics whereby the visual cortex itself develops. 33 34