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Microbial Reactions for the Production of Useful Organic Compounds

In recent years, the most significant development in the field of synthetic chemistry has been the application of biological systems to chemical reactions. Reactions catalyzed by enzymes and enzyme systems display far greater specificities than conventional forms of organic reactions. Of all the reactions available, enzymatic synthesis has the greatest potential. Studies on the production of various biologically and chemically useful compounds such as amino acids, ami des, acids, pyrogallol, theobromine, pantothenic acid, coenzymes, and polyunsaturated fatty acids using microbial enzymes as catalysts, have been carried out for more forty years in our laboratory in Kyoto University. An overview of the status of our work is presented in Table 1.