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Moclobemide (Ro 11‐1163) vs. clomipramine in the treatment of depression: A double‐blind multicenter study in Belgium

A multicenter study to compare the antidepressant efficacy and the tolerance of moclobemide (Ro 11‐1163) to clomipramine was performed in parallel groups of patients with minor depression. The duration of the study was 6 weeks, with weekly assessments by means of Hamilton Scale of Depression (HRDS) and the Clinical Global Impression (CGI). The efficacy of moclobemide was found to be as good as that of clomipramine. The results for tolerability were possibly in favor of moclobemide. It was recommended that consumption of tyramine‐containing foods be kept to a minimum or avoided and no hypertensive crises were reported.