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Molecular diagnosis of ectopic pregnancy

Ectopic pregnancy (EP) is implantation of a gestation in a location other than the uterus, most commonly in the fallopian tube. It is a major cause of maternal morbidity and is responsible for 6% of pregnancyrelated deaths [1]. Distinguishing normal from abnormal gestations is a clinical challenge because there is no definitive minimally invasive diagnostic test when ultrasound is not diagnostic. Currently, clinicians must follow patients over several days to 1 week, which increases the risk of EP-related rupture resulting in life-threatening intraabdominal hemorrhage [2]. Earlier diagnosis would permit early treatments with preservation of fallo pian tube function and fertility [2,3]. The develop ment of minimally invasive diagnos tics, such as novel multiplexed serum bio marker tests, to diagnose an EP with high accuracy would have tremendous clinical significance.