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ASSA14-11-04 Role of MiR-126 in development of hypertension MiR-126:a valuable predictor for hypertension

Objective Plasma microRNAs (miRNAs) have been recently reported to be sensitive and specific biomarkers of various tissue injuries and pathological conditions. MiR-126 plays an important role in maintaining endothelial cell homeostasis and vascular integrity. The goal of this study was to assess whether MiR-126 is good tool for the prognostication of hypertension. Methods The plasma concentrations of miR-126and miR-499 were assessed among patients with pre-hypertension and hypertensionby a real-time reverse transcription-polymerase chain reaction using an artificial small RNA as an internal. Results Plasma concentrations of miR-126 inpatients either with pre-hypertension (n = 22) or with hypertension (n = 36) were significantly lower than those in healthy controls (n = 15) (p < 0.01), and the concentrationsof hypertension group decreased more significantly. However, there was no difference in plasma concentrations of miR-499 among the study groups. Conclusions Thesefindings suggest that miR-126 may be a useful biomarker for pre-hypertension and clinical hypertension.