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INVESTIGATION OF THE CLINICOPATHOLOGICAL IMPORTANCE OF NEUTROPHIL-TO-LYMPHOCYTE RATIO AND PLATELET-TO-LYMPHOCYTE RATIO IN BREAST CANCER

AIM: In this study, we aimed to examine whether the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values of women operated for breast cancer were associated with their clinicopathological features. 
MATERIAL AND METHOD: The data of 463 females who were operated for breast cancer in our center between Januray 2015 and December 2020 were analyzed retrospectively. Age, menopausal status, hematological values, histopathological features of tumors, presence of hormone receptors, surgical and biopsy techniques were evaluated in detail. NLR and PLR values were calculated using the results of routinely performed hemogram test before the operation, and their relationships with all parameters were analyzed. 
RESULTS: The ages of the cases ranged from 23 to 88 years, with a mean of 53.57 ± 12.66. Postmenopausal women constituted 62.42% of the cases. A negative correlation was found between age and PLR, but neither PLR nor NLR were found to be associated with menopause status. It was found that high NLR value was associated with high N stage, high TNM stage, high number of metastatic lymph nodes and presence of extracapsular invasion (p