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Paraoxon‐induced changes in the level of cerebral acetylcholinesterase activity in diabetic mice

The central effects of a number of substances are known to be modified by the diabetic state (Wisniewski & Buczko 1967) or the administration of insulin (Leblanc 1960; Jasmin & Bonin 1960). It was previously reported that the administration of paraoxon resulted in significantly less accumulation of acetylcholine in the brains of diabetic than normal rats (Matin and Kar 1972). The organophosphorous compounds inhibit cholinesterase activity which is found in the central nervous system and other parts of body (Holmstedt 1959). The effect of these compounds on the level of cholinesterase in diabetic or insulin-treated animals has not been determined. We now report the effect of paraoxon on the level of cerebral cholinesterase activity in diabetic mice.