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The Different Expresion of p~(53) and p~(21) in Different Parts of Oral Squamous Cell Carcinoma

Objective: To study pathological grading and expressions of p 53 and p 21 in different parts of OSCC. Methods: 20 specimens of OSCC were investigated. Each specimen was separeded into 4 parts including surface, central, deep invasive, and normal tissue. A pathologic grade was made in all the parts. S P immunohistochemistry styiny method was used to study the expressions of p 53 and p 21 in different parts of OSCC.Results:70 percent of surface samples showed grade I. 65 percent of ceutral samples showed grade Ⅱ and 70 percent of deep invasive part did grade Ⅲ.There was a big difference between them ( P 0.01). The expressions of p 53 and p 21 were also defferent between the parts. Conclusion: The differentiation of deep invasive part is the poorest followed orderly by central and surfacer parts. This trend is also seen in expression of p 53 and p 21 with the highest positive rate of expressions in deep invasive part .