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Caveolin‐1 promotes the transformation and anti‐apoptotic ability of mouse hepatoma cells

Caveolin‐1 is a major structural protein of caveolae and plays important roles in signal transduction, cellular transformation and tumor metastasis. Our previous study demonstrated that caveolin‐1 expression level was positively correlated with the invasive ability of mouse hepatoma Hepa1‐6 and Hca‐F cells. However, the role of caveolin‐1 in cellular transformation and apoptosis remains undetermined. We found that exogenous expression of caveolin‐1 in Hepa1‐6 cells enhanced cell transformation capability both in vitro and in vivo and prevented actinomycin D‐induced apoptosis via the activation of survivin‐mediated survival pathway. Conversely, downregulation of caveolin‐1 in Hca‐F cells significantly attenuated cell transformation ability in vitro and in vivo and increased cell sensitivity to actinomycin D by inhibiting survivin‐mediated survival pathway. These results indicate that caveolin‐1 could play an active role in mediating the transformation and survival of mouse hepatoma cells and might be a potential target for gene and antitumor drugs therapy. © 2008 IUBMB IUBMB Life, 60(10): 693–699, 2008