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Preparation of Hepatic Microsomal Fraction for Drug Metabolism Studies by Rapid Decompression Homogenization

Summary The applicability of rapid decompression as a method for homogenization of liver in the preparation of a microsomal fraction has been studied. It was shown that this method is more efficient and probably less variable than homogenization with a Teflon pestle and glass tube. Increased efficiency was related to more complete cell disruption and probably to the production of smaller microsomal particles. The specific content and activity of components of the mixed function oxidase system of the microsomal fraction were similar to those produced with pestle and tube. Supported by Grant No. HD-03074, Institute of Child Health and Human Development, NIH.