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Progress in American ophthalmology from 1850 to 2000, as seen through the eyes of Frederick H. Verhoeff.

If anyone deserves to be honored as the most influential American ophthalmologist of the 20th century, Frederick H. Verhoeff, MD (1874-1968) certainly does. This man enjoyed a very long career as a professor of ophthalmic research at Harvard University (Cambridge, Mass) and the chief of ophthalmic research at the Massachusetts Eye and Ear Infirmary (Boston). 1-8 He made important contributions to a wide range of ophthalmic topics, from pathology and physiology to surgical techniques. The American ophthalmic pathology society is named in his honor, for it was largely his work that established the subspecialty of ophthalmic pathology. Independent, aggressive, and full of energy, he continually challenged his colleagues to be honest, even skeptical, observers if this would promote the scientific basis of patient care. He set very high standards for himself and expected the same of others. He published hundreds of journal articles over a 67-year period, the last at age 92 years on his perceptions of his own retinal venous occlusion.