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[Effects of ethanol on the pulmonary artery endothelium in rats].

Effects of ethanol on membrane potential and intracellular calcium concentration in intact endothelium of isolated pulmonary arteries were investigated. Ethanol evoked hyperpolarization and biphasic increase in [Ca2+]i in the endothelium due to both Ca2+ release from intracellular stores and Ca2+ entry from extracellular solution. These data allow endothelium-dependent dilation of pulmonary artery evoked by ethanol to be explained.