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Simulating the Chan-Hudspeth experiment on an active excised cochlear segment.

Hearing relies on a series of coupled electrical, acoustical, and mechanical interactions inside the cochlea that enable sound processing. The local structural and electrical properties of the organ of Corti (OoC) and basilar membrane give rise to the global, coupled behavior of the cochlea. However, it is difficult to determine the root causes of important behavior, such as the mediator of active processes, in the fully coupled in vivo setting. An alternative experimental approach is to use an excised segment of the cochlea under controlled electrical and mechanical conditions. Using the excised cochlear segment experiment conducted by Chan and Hudspeth [Nat. Neurosci. 8, 149-155 (2005); Biophys. J. 89, 4382-4395 (2005)] as the model problem, a quasilinear computational model for studying the active in vitro response of the OoC to acoustical stimulation was developed. The model of the electrical, mechanical, and acoustical conditions of the experimental configuration is able to replicate some of the experiment results, such as the shape of the frequency response of the sensory epithelium and the variation of the resonance frequency with the added fluid mass. As in the experiment, the model predicts a phase accumulation along the segment. However, it was found that the contribution of this phase accumulation to the dynamics is insignificant. Taking advantage of the relative simplicity of the fluid loading, the three-dimensional fluid dynamics was reduced into an added mass loading on the OoC thereby reducing the overall complexity of the model.