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[Comparative study of bisoprolol and celiprolol in to moderate hypertension using casual as well as ambulatory blood pressure measurements].

A randomised, parallel, double-blind trial was undertaken in 80 patients to compare the efficacy of bisoprolol with that of celiprolol, using causal (BPc) as well as ambulatory (AMBP) blood pressure measurement. After a two week wash-out and two week placebo run-in, patients in whom diastolic blood pressure (DBP) was between 95 and 114 mmHg were given either bisoprolol (10 mg/day) or celiprolol (200 mg/day) for 12 weeks. When efficacy was insufficient (DBP > 95 mmHg), the dose could be doubled after 4 weeks and a diuretic added after 8 weeks. BPc was measured at each visit and an AMBP obtained the day before the start of active treatment and at its end. Six patients dropped out of the trial because of adverse events. Clinical safety/acceptability of both drugs was good. Demographic data, and blood pressure and heart rate figures in both groups were comparable at the end of the placebo period. Mean fall in BPc in the bisoprolol group was 32.5/20.3 mmHg and 23/17.4 mmHg in the celiprolol group, with a significant difference between the two groups concerning systolic pressure (SBP). Ambulatory measurement showed evidence during the periods 24 hours (H), day and night, of a greater fall with bisoprolol (10.7/8.9 mmHg; 13.9/10.8 mmHg; 7.3/7.2 mmHg) than in the celiprolol group (4.9/21.6; 7.3/3.8; 2.9/2 mmHg), the difference being significant for diastolic blood pressure (DBP: p < 0.01; p < 0.05; p < 0.05. Thus bisoprolol was more effective than celiprolol in mild to moderate hypertension, but the difference was significant for SBP by casual measurement and for DBP by ambulatory measurement.