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Impact on survival of early detection of recurrence in the follow‐up of high risk Hodgkin lymphoma in first complete remission

mance status (ECOG > 1) (P = .01), stage IV disease (P = .01), and IPS (Hasenclever) score > 2 (P = .002). Furthermore, levels were lower in patients with hemoglobin below 10,5 g/dl (P = .06). No association was found with gender, albumin level, B symptoms. In addition, there was a significant seasonal variation, with 25(OH)D levels to be lowest in the first quarter and highest in the third quarter (P = .03). FDG‐PET evaluation after 2 cycles of chemotherapy according to the 5‐point Deauville scale was available in 66 patients. Vitamin D levels were not associated with interim PET response.With a median of 12 months follow‐up of patients is still short. Patients with deficient levels (n = 9) had a significantly worse PFS than patients with higher levels (n = 67) (P = .002). The probability of progression‐free survival at 12 months was 87% (95% CI, 75%‐94%) in patients with 25(OH)D levels >10 ng/ml, while patients with levels <10 ng/ml had a 12 months PFS of 47% (95% CI, 12%‐76%). We included 25(OH)D levels, IPS (that includes age, stage and hemoglobin level), ECOG, and season in a multivariate Cox analysis. Deficient 25(OH)D level had a borderline significance (HR, 5.65; 95% CI,0.98‐32.55; P = .05). Conclusions: 25(OH)Vitamin D serum levels are frequently low in patients with Hodgkin lymphoma and are associated with patient‐ related and disease‐related characteristics. Our preliminary analysis suggests that low 25(OH)D levels might be associated with worse prognosis.