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Evaluation of the Effect of Laminin-Derived YIGSR Peptide on HUVEC Micro-Tissue Formation

The vascularization is a quite significant process in tissue engineering studies. Human Umbilical Cord Vein Endothelial Cells (HUVEC) are one of the most preferred endothelial cells due to their suitability for 3D tissue studies and their ability to form vessels. Peptides have an active role in micro-tissue formation. Especially laminin-derived peptides are frequently used in micro-tissue studies. The aim of this study is to determine the efficacy of the laminin-derived peptides in 3D HUVEC cell culture. In this project, it was observed that the laminin-derived 1.5 mM tyrosine-isoleucine-glycine-serine-arginine (Tyr-Ile-Gly-Ser-Arg (YIGSR)) peptide can enhance the formation of HUVEC micro-tissue.