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False negative screening tests in phenylketonuria.

Weight loss at 1 week of age, expressed as a percentage of birthweight was less in the orotic acid treated group (mean 5-3%, range 0-11%) than in those receiving aspartic acid (mean 7-2%, range + 1 * 6-15%) or glucose (mean 7 * 9%, range 1-16%). Maximum serum bilirubin levels were not related to weight loss at 1 week whether expressed in this fashion or in absolute amounts, nor were they closely related to the initial weight of the infant. The infants were closely observed in an intensive care unit throughout the study but showed no adverse effects from these products. Of the 34 infants, 27 (80%) have now been examined at the age of 9 months. All are developing normally.