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The metabolic syndrome, the Guy syndrome and the hypofit syndrome.

The concept of metabolic syndrome [1] has recently fascinated a great number of practising physicians and investigators. During the last five years (2001–2005), the Internet PubMed library has catalogued more than 7000 papers on this issue worldwide (http://www. pubmed.org). The impression is that the idea of the metabolic syndrome has induced to forget a great deal of what we know about cardiovascular risk factors and their association with subsequent cardiovascular events, and that a new era has started in the field of prediction and causality of cardiovascular diseases and their prevention. Another impression is that the insistence on the metabolic syndrome is simply a way to usurp the aseptic concept of multivariate or multidimensional prediction of cardiovascular diseases, ignoring, among other things, the role of total cholesterol, low-density lipoprotein or nonhigh-density lipoprotein cholesterol as well as the role of other components, among which some behavioural factors such as smoking habits and physical activity.