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[Involvement of rat locus coeruleus in the analgesic effect induced by monosodium glutamate injection into the hypothalamic arcuate nucleus area].

With tail stimulatlon-vocalization test and formalin test,it was observed that:(1)microinjection of neuronal perikarya excitant,monosodium glutamate (MSG)300μg into the arcuate nucleus (ARC) area of the rat hypothalamus could markedlyproduce analgesic effect;(2)microinjection of β-endorphin antiserum(0.1μl×2)into bilateral locus coeruleus (LC) could significantly decrease the analgesic effectproduced by MSG injection into ARC area;and (3) direct microinjection of β-endorphin(1μg×2)into bilateral LC could also markedly produce the analgesiceffect,which is similar to that produced by MSG injection into ARC area.These results suggest that the analgesic effect of MSG injection into ARC areamight be mediated by the activation of β-endorphin-containing neurons in ARCarea,which may,in turn,release β-endorphin from its descending fibers to influencethe activity of LC neurons and,result in the analgesic effect subsequently.