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Retinol binding protein in normal human skin and in cutaneous disorders

Circulating vitamin A is transported by a carrier termed retinol binding protein (RBP). Autoradiography and immunofluorescence studies showed that, in normal human skin, RBP is confined exclusively to the dermis. Following oral vitamin A loading, a large increase in dermal RBP but only a very small rise of serum RBP was found.