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Book Review: Current Surgical Practice, Vol 3

Fifty Years On: Looking Back on Some Developments in Neurohumoral Physiology W S Feldberg pp 106 £6.25 Liverpool University Press 1982 This small monograph is based on the author's recent Sixteenth Sherrington Lectureat the University of Liverpool. The book contains a fascinating historical account of his crucial experiments with Dale and Vogt during the thirties, in which they were the first to demonstrate that acetylcholine is released as the neurotransmitter at motor nerve endings and in autonomic ganglia. This first section of the book provides a vivid insight into the flourishing world of British physiology and pharmacology at that time, with such giants as Langley, Joseph Barcroft and Sir Henry Dale at large. It is characteristic of the man, however, that he is clearly impatient with the historical introduction and more anxious to tell his readers of his most recent experimental findings; for the author after fifty years of research continues to be very active as an experimentalist. During the past two or more decades he has pioneered the study of the brain's responses to transmitters and drugs when applied to its surface or into various parts of the ventricular system. His remarkable ability to remain at the forefront of neuropharmacology is well illustrated by the account of studies undertaken during the past few years which demonstrate the remarkably potent and long lasting analgesic effects elicited by 13-endorphin and related peptides when administered into CSF. This is a highly personal account, and one of considerable charm and wit; the book is certainly to be recommended to those who wish to understand better the basis of the modern avalanche of research interest in chemical mediators in the nervous system.