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Evolution of cutaneous lymphoid hyperplasia to cutaneous T‐cell lymphoma

Single cell DNA measurements have recently been used in diagnosis and as a measure of treatment response in different premalignant and malignant conditions. In the present case evolution of cutaneous lymphoid hyperplasia to cutaneous T‐cell lymphoma was demonstrated by histological and immunohistological criteria. However, using single cell DNA measurements clear aneuploidy, by an additional peak in the hyperdiploid region of the DNA histogram, was revealed both in the benign and malignant stages of the disease. Lymph node and peripheral blood were normal by histopathological, immunohistopathological and single cell DNA measurements, indicating that the malignant potential may have been confined to the skin. Thus, single cell DNA measurements may be used as an additional diagnostic tool, when the diagnosis is inconclusive or at variance with the clinical findings.