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Percutaneous transvesical chorionic villus sampling: a safe alternative method for difficult procedures?

Chorionic villus sampling (CVS) is a safe and effective procedure for invasive prenatal diagnosis in the first trimester, with a 1% risk of miscarriage as a result of patientor procedure-related variables, including operator experience1–3. CVS is an ultrasound-guided procedure generally performed transabdominally. Occasionally, transabdominal CVS is difficult because of an axial-retroverted uterus, a posterior low-lying placenta (interposed bowel) or the presence of uterine myomas, and so alternative approaches are required: transvaginal transcervical CVS or percutaneous transvesical CVS3,4. We retrospectively analyzed our series of difficult CVS procedures to evaluate