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New genes often acquire male-specific functions but rarely become essential in Drosophila

In this study, Kondo et al. performed large-scale CRISPR/Cas9 mutagenesis of “conserved, essential” and “young, RNAi-lethal” genes and confirmed the lethality of conserved genes but not young genes. Additionally, two young gene mutants resulted in spermatogenesis and/or male sterility, indicating that young genes have a preferential impact on male reproductive system function.