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Isocaloric Two-intensity Intermittent Exercise Blunts Detection, Leptin Response, And Dietary Compensation In Obese Women: 3048 June 2 3

PURPOSE: Whether obesity can influence appetite, hormonal responses to, and compensation for exercise energy expenditure (EEE) is uncertain. We tested the hypotheses that: (1) EEE suppresses appetite but increases post-exercise food intake independently of obesity, and (2) the effect may be mediated by energy-sensing hormones leptin and insulin. METHODS: The 57-y old lean (BMI 23.4 kg/m 2 ) and obese (BMI 33.6 kg/m 2 ) women remained sedentary (SED) or did iso-caloric highor a low-intensity, intermittent exercise (HIIE 80%, LIIE 40% of VO2max, respectively) one h after the morning (0700 h) and mid-day (1300 h) weight-maintenance meals. After the evening 1900 h meal, an adlibitum snack (2100 h) assessed compensation for EEE. A visual analog scale evaluated the appetite. Plasma glucose, FFAs, insulin and leptin were measured at 30 to 60min intervals. RESULTS: RESULTS. Meal intake (1350 vs 1473 Kcal) and mean EEE at two intensities during morning and mid-day postprandial periods (PPs) (1821 and 2202 Kcal) were similar in lean and obese women, respectively, as was EE during SED day (758 and 818 Kcal). This resulted in 529 and 380 Kcal positive energy balance on SED days and a 471 and 729 Kcal negative energy balance on exercise days in lean and obese women, respectively. Lean women ate an additional 256, and obese women 261 Kcal, of adlibitum snack in SED trials. On LIIE and HIIE days, lean women increased snack intake by 24.6 and 37.9 %, respectively, but failed to compensate for 32 and 25% of exercise energy deficit. Corresponding increases of snack intake by obese women to LIIE and HIIE was 6 and 15%, and the compensation for EEE failed by 62 and 58%, respectively. Hunger was similarly suppressed during mid-day, but not morning, LIIE and HIIE in lean, but not the obese subjects, while obesity did not affect PP fullness. In LIE and HIE trials at mid-day, but not morning, exercise, a rise in FFAs was greater in lean than in the obese. In lean, but not the obese women, exercise suppressed PP insulin responses and led to a 5%, 12-h-sustained decline in plasma leptin. CONCLUSIONS: EEE at intensities differing by a factor of two, suppresses hunger after the mid-day meal, PP insulin after morning and mid-day meals and leptin over a 12-h period in lean, but not the obese women. Obesity blunts detection, hormonal responses, and dietary compensation to EEE.