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Differentiation of follicular dendritic sarcoma cells into functional myeloid‐dendritic cell‐like elements

Abstract: In a rare case of follicluar dendritic cell sarcoma, malignant cells were isolated and cultured in the presence of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), interleukin 4 (IL‐4) and tumor necrosis factor alpha (TNF‐α). After 14 d, 15% of neoplastic cells differentiated into myeloid‐dendritic cell‐like elements as demonstrated by immunological and functional characteristics.