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In vivo lung elastography with hyperpolarized helium-3 MRI

-1 motion sensitizing gradients, synchronized with the mechanical wave through a trigger pulse, were set along the three directions, x (phase), y (reading) and z (slice) at different time offsets with respect to the excitation. As a result, four snapshots of the propagating wave during one oscillatory cycle could be acquired. Eventually a fourth acquisition was performed to include a reference data set without motion sensitizing gradients. The images of the three middle slices were averaged and manually masked. The resulting phase data were then unwrapped so displacement maps could be inferred over the lungs 3 . Results Figure 2 shows the 3-slice averaged magnitude image (2a), the reference displacement maps acquired without any motion sensitizing gradient (2b), and the displacement maps acquired with motion sensitizing gradient along the three directions (2c-e). a. Magnitude image b. Reference image c. Displacements along x d. Displacements along y e. Displacements along z Figure 2: (a) Magnitude image over the three middle slices and corresponding displacement maps (µ m) (b) without motion sensitizing gradients and with motion sensitizing gradient (c) along the phase encoding direction, x, (d) along the reading direction, y, and (e) along the slice selection, z. Shear displacements reached amplitudes of 118, 153, and 117 µ m when motion sensitizing gradients were respectively applied along x, y, and z. They are limited to 48 µ m in the reference image. Figure 3 shows the corresponding four dynamic displacement maps along y.