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Basophil Histamine Release and Humoral Changes during Immunotherapy

An in vitro pilot study was performed to determine whether basophil cell‐bound specific IgE was correlated to serum‐specific IgE and to basophil cell sensitivity during immunotherapy with a well‐documented treatment. The findings showed a clear dissociation between these three parameters, which is in contrast to the situation before hyposensitization and to our previous study in a comparable group of non‐hyposensitized patients, where highly significant correlations were observed. Further investigations are in progress to clarify whether the dissociation is involved in the clinical improvement.