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Implication of ferroptosis iron‐dependent programmed cell death mechanism in neurodegeneration

Besides the abnormal accumulation of hyperphosphorylated tau, amyloid‐β plaques and neuroinflammation, progressive synaptic loss and neuronal cell death are persistent pathological hallmarks related to the development of neurodegeneration. However, the cellular pathways/mechanisms that trigger neuronal death in AD remain largely undefined. A detailed understanding and description of the molecular mechanisms related to neuronal loss processes in affected AD will be invaluable to the identification and development of new effective therapeutic targets. A novel form of iron‐dependent regulated cell death process termed ferroptosis was recently identified. Misregulated ferroptosis pathways have been speculated to trigger neurodegeneration, but the cellular mechanisms and signaling are not completely understood.