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Coenzyme Q10 supplementation in traumatic brain injury: a scoping review protocol.

OBJECTIVE
The objective of this review is to map evidence on CoQ10 use in traumatic brain injury (TBI).


INTRODUCTION
Traumatic brain injury is an insult to the brain structure caused by external force resulting in physiological disruption to brain function. Globally, 60% of all TBIs occur from road traffic accidents. In 2016, the World Health Organization reported that road traffic accidents were in the top 10 leading cause of death. Following the initial brain injury, a secondary injury can occur due primarily to a significant increase in production of free radicals causing oxidative stress which can dictate the patient's ability to survive. Coenzyme Q10 (CoQ10) is known to protect neuronal cells from oxidative stress; the mechanism for this has been examined in studies using rats. This review will examine what is known about CoQ10 in TBI and identify gaps in the literature which may guide future research.


INCLUSION CRITERIA
The review will include both human and animal subjects who have experienced a TBI in the acute/laboratory controlled setting and where CoQ10 is supplemented. Animal studies will be included. The review will consider experimental and quasi-experimental study designs including randomized controlled trials, non-randomized controlled trials, before and after studies, and interrupted time-series studies.


METHODS
Searches will be conducted in the Cochrane Library, JBI Database of Systematic Reviews and Implementation Reports, CINAHL and trial registries. Data will be extracted and presented on details about the population, concept, context, study methods and key findings.