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Native C‐reactive protein does not increase formation of atherosclerotic lesions in apolipoprotein E‐deficient mice

Background: C‐reactive protein (CRP) levels are associated with endothelial activation and development of atherosclerosis. Confirmation of this association in vivo remains controversial. Some researchers reported a pro‐atherosclerotic effect of CRP in ApoE‐deficient mice (apoE−/−) and others did not. Here we treated apoE−/− mice with azide‐ and endotoxin‐free native‐CRP (n‐CRP), then evaluated the extent of atherosclerosis.