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Biochemical studies on marine fish oil part-I: effects of fish oil and lipid lowering drugs on HDL/LDL cholesterol levels.

Omega-3 fatty acids present in fish oil are potent cholesterol lowering agents. This fact has drawn our attention to investigate their effects alone and in combination with competitive inhibitors, (hydrooxymethylglutaryl coenzume-A reductase). The naturally occurring omega-3 fatty acids i.e., polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in fish oil have been proved as anticholesterolemic agents. In order to observe their actions as lipid lowering agents, the present study has been carried out which deals with the synergistic effect of fish oil with that of Lovastatin and Gemfibrozil.