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EP944 Isolated lymph node recurrence in epithelial ovarian cancer: a recurrence with better prognosis?

Introduction/Background The aim of this study was tocompare in patients managed for epithelial ovarian cancer; overall survival (OS) between women with isolated lymph node recurrence (ILNR) to those with isolated peritoneal localization of recurrence (ICR). Methodology Data from 1,508 patients with ovarian cancer were retrospectively collected, from January 1, 2000 to December 31, 2016, from the FRANCOGYN database, regrouping data from 11 centers specialized in ovary treatment. Median overall survival was determined using the Kaplan-Meier method. Patients included had a first recurrence defined as ILNR or isolated peritoneal recurrence during their follow up. Results 79 patients (5.2%) presented ILNR, and 247 (16.4%) patients recurred with isolated carcinomatosis. Complete lymphadenectomy was more achieved in ILNR group vs ICR group (67.1% vs 53.4%, p=0.004) and the number of pelvic lymph nodes involved was higher (2.4 vs 1.1, p=0.008). The number of involved pelvic LN was an independent predictor of ILNR (OR=1.231, 95% CI [1.074–1.412], p=0.0024). The 3-year and 5-year OS in the ILNR were 85.2% and 53.7% respectively, compared to 68.1% and 46.8% in patients with ICR. There was no significant difference in terms of OS after initial diagnosis (p=0.18). 3- year and 5-year OS after the diagnosis of recurrence were 62.6% and 15.6% in the ILNR group, and 44% and 15.7% in patients with ICR (p=0.21). Conclusion ILNR does not seem to be associated with a better prognosis in terms of OS. Disclosure Nothing to disclose.