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Hepatic medication injury

The liver plays a central role in the metabolism of most drugs and is often the target of drug-related toxicity. In the intensive care setting, patients may develop drug-related toxicity as a result of medications used in the care of their acute illness, or their admission to the intensive care unit may be precipitated by severe drug hepatotoxicity. Identification of drug-related toxic reactions is essential, because prompt discontinuation of the offending agent is the most effective mode of therapy. With the development of new drugs and the recognition of the hepatotoxic potential of existing drugs, the critical care specialist needs to keep abreast of the many reports related to drug-induced hepatotoxicity.