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The contribution of Robert William Kerwin (1955-2007) to psychiatry in Brazil.

A contribuição de Robert William Kerwin (1955-2007) para a Psiquiatria brasileira Recently, the world scientific community and particularly our Revista Brasileira de Psiquiatria (Brazilian Journal of Psychiatry) had a great loss: Professor Robert W. Kerwin, from Great Britain. Robert Kerwin’s career was full of singularities and brilliance. In 1979, he started his studies toward a PhD degree at the University of Bristol. Two years later, at the early age of 25, he completed several pharmacological studies in animals investigating the action of different neurotransmitters in the brain. These studies generated more than a dozen articles published in specialized periodicals between 1979 and 1981, including a highly cited publication in Nature. This paper, on the biochemical characterization of the newly discovered frontal cortical dopamine systems, was of critical importance to the understanding of dopaminergic mechanisms involved in psychosis and other psychiatric conditions. Rob (as he preferred to be called) later pursued the conclusion of his medical education and, by 1988, he completed his training in Psychiatry at the Maudsley Hospital in London. Only two years later, he was appointed Senior Lecturer jointly in Psychiatry and Neuroscience at the Institute of Psychiatry (IoP) of the University of London, and Consultant Psychiatrist at the Maudsley Hospital. At the IoP, he pioneered the use of both post mortem molecular approaches working with Prof. Ian Everall, and in vivo functional imaging techniques to the study of glutamatergic, GABAergic and dopaminergic hypotheses of schizophrenia. At the same time, he mentored the IoP team that, under the leadership of Prof Lyn S. Pilowsky, implemented in vivo receptor imaging studies investigating the brain receptors occupancy by all antipsychotic agents. He also established in Great Britain the application of pharmacogenetic studies to the investigation of the relationship between neurotransmitter genes and the response to psychopharmacological agents, together with Dr. Maria Arranz and Dr. David Collier. In 1996, he was appointed Professor of Clinical Neuropharmacology at the IoP, and Head of the Department of Clinical Pharmacology of King’s College School of Medicine and Dentistry, being the youngest psychiatrist ever to reach those positions. He raised huge amounts of funds from research agencies to finance his studies and staff, and published many dozens of research articles that have been cited with great regularity in the scientific literature on his fields of interest. Tributes to the significance of his scientific contributions are currently being paid internationally. The invitation for Rob Kerwin to become a member of RBP’s international editorial board came in 1999, in recognition to his important influence on the start up of Neuroscience research applied to Psychiatry in Brazil. Rob first visited Brazil in 1990, invited by the Institute of Psychiatry of the Medical School of the Universidade de São Paulo (IPQ-HCFMUSP). During his stay, he taught a course on the neurochemistry of schizophrenia, gave several lectures, and discussed different projects and research ideas with local Editorial