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Temporal and Long-term Gut Microbiota Variation in Allergic Disease: A Prospective Study from Infancy to School Age

Sjodin K Simonyte, ML Hammarstrom, P Ryden. Allergy. 2019;74(1):176–185

How the early-life gut microbiota changes over time has been implicated in the development of immunoglobulin E– (IgE) mediated allergic diseases, but there is lack of data from longitudinal studies. In this study, researchers compared gut microbiota from infancy to school age in relation to the onset of allergic disease while also examining the relationship of gut microbiota to T-cell activation at age 8 years.

Ninety-three children were included from a randomized, placebo-controlled trial in which researchers investigated the effects of probiotics for primary prevention of allergic disease. That original trial group consisted of 179 …