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Chiral resolution of the insecticide fipronil enantiomers and the simultaneous determination of its major transformation products by high-performance liquid chromatography interfaced with mass spectrometry.

A high-performance liquid chromatography-mass spectrometry (HPLC-MS) method was developed using a chiral column based on amylose tris(3-chloro-5-methylphenylcarbamate) for analysis of fipronil (a popular insecticidal nerve agent) and the related transformation products. The optimized method reached the goal of the simultaneous and complete separation of the multiple fiproles in a single run, including the chiral separation of fipronil enantiomers, fipronil metabolites, and photoproducts. The efficacy of such a method was demonstrated by its application in analyzing a series of fipronil samples exposed to sunlight conditions. In general terms, our study provided experimental approaches and an efficient analytical tool for monitoring the environmental fate of fipronil as well as its multitransformation products upon its applications either in agricultural or any other areas.