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Diagnostic Accuracy of Xpert MTB Compared to Smear Microscopy in Pulmonary vs Extrapulmonary Tuberculosis

introduction: Mycobacterium tuberculosis is the most significant infectious disease causing death worldwide. Inability to rapidly diagnose and treat the affected patients leads to increased morbidity and mortality, development of secondary resistance. There is sparse data which show the accuracy of diagnosis of tuberculosis by Gene Xpert in patients. There is limited data on the usefulness of Xpert MTB in the diagnosis of extrapulmonary TB. Study aimed to evaluate the diagnostic accuracy of XpertMTB compared to smear microscopy in pulmonary and extra pulmonary tuberculosis. Material and methods: Prospective observational study conducted from May 2017 to July 2017. The study was conducted in Department of medicine, Department of pulmonology at R.L.Jalappa hospital and research centre, Kolar. 139 tubercular suspects who were not human immune deficiency virus (HIV) positive were included in the study. result: Out of 139 patients 72 were males and 67 were females. 99 pulmonary samples and 40extrapulmonary samples were obtained. 93 pulmonary samples and 24 extrapulmonary samples were culture positive. Smear microscopy has lower sensitivity in diagnosing pulmonary TB (46.2%) as well as extrapulmonary TB(16.6%). Conclusion: The Xpert MTB is a rapid, sensitive and a reliable diagnostic test for TB than smear microscopy in both pulmonary as well as extra pulmonary TB. The diagnosis of extrapulmonary TB should not solely depend on the results of Xpert MTB and should be subjected to culture of Mycobacterium.