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The effect of drugs on accumulation of exogenous norepinephrine by nervous tissue in vitro.

The effect of hydrocortisone and prednisone on accumulation of exogenous norepinephrine was tested in nervous tissue in vitro, taken from rats at various periods of the postnatal life. The results indicate that exogenous norepinephrine is taken up by either uptake1 or uptake2 or both, depending on the age of explant donors and the kind of the cell. Uptake1 appearing predominantly in the tissue from young animals, in first days of postnatal life, differs from the uptake2 in the cardiac muscle in that it is inhibited by hydrocortisone, inactive in this respect in the heart.