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Formulation and Evaluation of in situ Gel Drug Delivery System of Sesbania grandiflora Flower Extract for the Treatment of Bacterial Conjunctivitis

The purpose of the present investigation was to prepare and evaluate in situ gel for Sesbania grandiflora flower extract which acts as anti-bacterial and anti-fungal agent using thermo reversible polymer. For improved drug residence time with corneal epithelium, formulation was prepared in the liquid state at 4°C while turned into a gel at the temperature of the Cul de sac. Pluronic F127 and Chitosan were used as the polymers which exhibited the phase transition behavior. Natural polycationic polymer chitosan was used to improve residence time. The prepared formulations were characterized for pH, physical appearance, content uniformity, gelling temperature, viscosity, in vitro diffusion, anti-bacterial, anti-fungal activity, sterility testing, and eye safety test. The formulation exhibit drastic increase in the viscosity at the temperature of 37°C indicating there possible use in in situ gelling systems. Out of all the formulations studied the G4, i.e., Pluronic (17%) chitosan (0.3%) formulation shows the desired drug with prolong contact time with antimicrobial efficacy.