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A step toward physiologically guided chronic limb‐threatening ischemia intervention

• Spatial and quantitative measures of end-tissue perfusion and oxygenation are an unmet need in the care of chronic limb-threatening ischemia (CLTI) patients. • Pedal artery sheath measurements of pedal pressure are feasible, safe, and predictive of limb survival. • Extending this concept to other endovascular access sites and open surgery, multiple novel approaches may soon permit real-time intraprocedural physiological measures to quantitatively inform revascularization and long-term management of CLTI patients.