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In vitro genotoxicity of extracellular extract from Nostoc piscinale

The extracellular extract obtained from 3 weeks incubation of the soil isolate cyanobacterium strain Nostoc piscinale GT-319 in BG-11 broth medium showed cytotoxic activity against Chinese Hamster Ovary (CHO) cells. Based on comet assay, a concentration of 333 µg mL−1 (IC50) produced DNA breakages in CHO cells. The concentration of 481 mg kg−1 (LD50) produced acute toxicity in mice at 48 h.