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Association between Grade 4 Neutropenia and Abnormal Liver Function Test Values after Initial Administration of Docetaxel for Prostate Cancer Patients

Received March 10, 2020 Accepted August 29, 2020 The use of docetaxel as the primary treatment for metastatic castration-resistant prostate cancer is frequently associated not only with neutropenia but also liver dysfunction. Neutropenia in most patients is usually accompanied by liver dysfunction, but the relationship between the two disorders is unclear. In this study, by analyzing the alanine aminotransferase (ALT) levels of 60 patients who received initial docetaxel therapy, the relationship between grade 4 neutropenia and liver function was investigated. With regard to neutropenia, 31 patients developed grade 4 and 29 developed grade 0 – 3, with mean ALT levels of 34.1 ± 26.6 U/L and 22.3 ± 11.7 U/L, respectively. ALT levels were higher in grade 4 neutropenia than grade 0 – 3 neutropenia. The increase in ALT was negatively correlated with the decrease in neutrophil count. In the grade 4 neutropenia group, the mean ALT level before docetaxel treatment and the previous nadir neutrophil count signi cantly increased from 19.5 ± 7.4 U/L to 30.1 ± 19.5 U/L. Furthermore, between the two groups, ALT uctuation was signi cantly greater in the grade 4 neutropenia group. The observed uctuations in ALT after docetaxel administration were important, as patients with elevated ALT had a high incidence of grade 4 neutropenia after administration; thus, careful monitoring of the neutrophil count may be required.