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[The antihypertensive effect of lisinopril in a single daily dosage. A study of arterial pressure with ambulatory monitoring].

We studied 25 patients with hypertension documented through ambulatory blood pressure monitoring (ABPM) to know the antihypertensive effect of Lisinopril and its action throughout the day. ABPM was done in all patients after two weeks of washout (phase 1). Then patients took 20 mg daily of Lisinopril during four weeks and after that ABPM was repeated (phase 2). Finally, those patients who persisted with high blood pressure received 40 mg daily of Lisinopril during four more weeks and again ABPM was repeated (phase 3). We found statistic difference in the systolic and diastolic blood pressure among the three phases. During the first phase there were 17 patients (68%) with high blood pressure and this number decreased to 8 (32%) in the second one and to 7 (28%) in the third phase. The results show that Lisinopril has satisfactory antihypertensive effect in about 40% of patients. Nevertheless 20% of the case remained with high blood pressure despite treatment with 40 mg of Lisinopril. On the other hand, both, systolic and diastolic blood pressure decreased satisfactory during the night with the dosage received in the morning. We concluded that Lisinopril has moderate effect when it is given as monotherapy and, it has satisfactory effect all over the day.