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Are circulating relaxin levels related to pulmonary hypertension in patients with heart failure?

We read with interest the article entitled ‘Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload’1 showing an association between higher plasma relaxin concentration and echocardiographic signs of right-sided cardiac pressure overload. These data led us to investigate the association between endogenous relaxin levels and invasively determined intracardiac pressures in patients with heart failure and a preserved ejection fraction (HFpEF). By means of this letter, we would like to share these data with you. We used a well-defined cohort consisting of 52 patients with pulmonary hypertension