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[Human chromosomal polymorphism and reproductive function disorder. III. Extreme autosomal C-variants: an analysis of their distribution and combination in the karyotype].

Distribution of extreme C-stained polymorphic variants of autosomes 1, 9, 13-16 21 and 22, alone and in combinations, was studied in married couples with reproductive failure (200 individuals) and in couples having normal children. There were no significant differences between the frequencies of extreme C-band variants (total and "plus"-variants) for two sexes in control group. Individuals of this group had combination of one of two extreme variants and one heteromorphic pair (out of three possible) pairs of chromosomes, 1, 9 and 16 per individual karyotype. There was a significant increase of the frequencies of extreme C-band variants (total and "plus"-variants) in women with reproductive failure comparing to the men of the same group and to the women of the controls. There was significant difference in frequencies of individuals with combination of three extreme C-band variants per one karyotype in women with the reproductive failure comparing to men of the same group.