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Lung Function, Airway Remodeling, and Inflammation in Infants: Outcome at 8 Years

K Malmstrom, LP Malmberg, R O’Reilly Ann Allergy Asthma Immunol 2015;114(2):90–96

To determine the predictive value of lung function and airway pathology in infancy for asthma, lung function, airway responsiveness, and purchase of asthma medications at 8 years of age.

The study included 47 of 53 children who had undergone pulmonary function testing and bronchoscopy in infancy because of recurrent lower respiratory tract symptoms who were available for follow-up at 8 years of age, compared with 63 healthy, age-matched controls who were able to perform spirometry.

Current or past symptoms, physician-diagnosed asthma, use of inhaled …