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Perioperative Cumulative Fluid Balance and Its Association with an Increase in Costs after Major Surgery

Positive fluid balance (FB) during the perioperative period may increase the incidence of postoperative complications, which may lead to longer hospitalization and higher hospital costs. However, a definitive association between positive FB and hospital costs has not yet been established. This retrospective observational study examined the association between perioperative FB and hospital costs of patients who underwent major surgical procedures. Medical records of patients who underwent major surgery (surgery time >2 h, estimated blood loss >500 mL) from January 2010 to December 2017 were analyzed to determine the associations between calculated FB (%, total input fluid—output fluid in liter/weight (kg) at admission) and total hospital cost ($). The analysis included medical data of 7010 patients. Multivariable linear regression analyses showed that a 1% increase in FB in postoperative day (POD) 0 (24 h), 0–1 (48 h), 0–2 (72 h), and 0–3 (96 h) significantly increased the total cost by $967.8 (95% confidence interval [CI]: 803.4–1132.1), $688.8 (95% CI: 566.3–811.2), $591 (95% CI: 485.7–696.4), and $434.2 (95% CI: 349.4–519.1), respectively (all p < 0.001). Perioperative cumulative FB was positively associated with hospital costs of patients who underwent major surgery.


Introduction
Perioperative fluid therapy is an important factor that may affect the prognosis of patients undergoing surgery [1][2][3] and, therefore, it is an indispensable issue in clinical practice [4]. Several perioperative fluid management strategies have been studied so far; liberal and restrictive fluid therapies are two widely used regimens [5]. Restrictive fluid therapy has been demonstrated to prevent positive fluid balance (FB) and achieve a "zero FB" status, and to reduce the incidence of postoperative complications [6,7] as well as the length of hospitalization [5,8]. As such, reductions are closely related to lowering total hospital costs; hence, perioperative fluid management is also an important economic issue [9,10]. Thus, perioperative fluid strategy to prevent positive FB is an important factor that is associated with postoperative complications, length of hospitalization, and hospital costs of a surgical population.
In recent years, studies have begun to use weight-based FB (%), which considers not only fluid input value, but also the amount of fluid output and patients' weight at admission [11,12]. Such FB calculations in percentages using patients' weight have been effectively used in the fluid management of critically ill or pediatric patients, who are more sensitive to fluid imbalance. Using weight-based FB allows for a more effective prediction of the associations between positive FB and postoperative outcomes of a surgical population, as well as hospital costs. However, a definitive association between FB and hospital costs of a surgical population has not yet been established. Thus, the present study aimed to examine the association between weight-based FB and hospital costs of patients who underwent major surgical procedures. We hypothesized that positive FB would be positively associated with total hospital costs and daily costs.

Materials and Methods
This study was approved by the Institutional Review Board (IRB) of Seoul National University Bundang Hospital (SNUBH) (approval number: B-1803/459-105, approval date: 12 March 2018). The requirement for informed consent was waived by the IRB as this was a retrospective cohort analysis.

Patients
Medical records of patients aged 19 years or older who underwent a major surgery at SNUBH from January 2010 to December 2017 were retrospectively analyzed. Major surgery was defined as a surgery that exceeded two hours with an estimated blood loss (EBL) of more than 500 mL. Incomplete or missing medical records were excluded from the analysis.

Calculation of Costs for Major Surgical Procedures
Most patients in Korea are enrolled in the National Health Insurance Service (NHIS) provided by the Korean government as required by law, which covers approximately two-thirds of essential medical costs within hospitals [13]. In the present study, each patient's total hospital cost was calculated by summing up the patient's out-of-pocket cost and costs covered by the NHIS. Daily cost was defined as the value obtained by dividing the patient's total hospital cost by the length of hospitalization. In addition, non-coverage by the NHIS (%) was defined as the value from the following equation: patient's out-of-pocket cost/the total hospital cost × 100. All costs were first computed in Korean currency, won ( ht-based FB allows for a more effective prediction of the associations between positive FB and operative outcomes of a surgical population, as well as hospital costs. However, a definitive ciation between FB and hospital costs of a surgical population has not yet been established. Thus, present study aimed to examine the association between weight-based FB and hospital costs of ents who underwent major surgical procedures. We hypothesized that positive FB would be tively associated with total hospital costs and daily costs.

aterials and Methods
This study was approved by the Institutional Review Board (IRB) of Seoul National University dang Hospital (SNUBH) (approval number: B-1803/459-105, approval date: 12 March 2018). The irement for informed consent was waived by the IRB as this was a retrospective cohort analysis.

Patients
Medical records of patients aged 19 years or older who underwent a major surgery at SNUBH January 2010 to December 2017 were retrospectively analyzed. Major surgery was defined as a ery that exceeded two hours with an estimated blood loss (EBL) of more than 500 mL. Incomplete issing medical records were excluded from the analysis.

Calculation of Costs for Major Surgical Procedures
Most patients in Korea are enrolled in the National Health Insurance Service (NHIS) provided he Korean government as required by law, which covers approximately two-thirds of essential ical costs within hospitals [13]. In the present study, each patient's total hospital cost was ulated by summing up the patient's out-of-pocket cost and costs covered by the NHIS. Daily cost defined as the value obtained by dividing the patient's total hospital cost by the length of italization. In addition, non-coverage by the NHIS (%) was defined as the value from the wing equation: patient's out-of-pocket cost/the total hospital cost × 100. All costs were first puted in Korean currency, won (₩), and then converted to the equivalent in U.S. dollars ($) based he exchange rate of 1060 won = 1 dollar to express the unit of costs in dollars.

Measurement and Outcome
Demographic information (age, body mass index, and sex), preoperative comorbidities, and ery-related information of the patients were extracted. The collected preoperative comorbidity rmation included hypertension, diabetes mellitus, history of ischemic heart disease and brovascular disease, liver disease (hepatitis, liver cirrhosis, hepatocellular carcinoma), and er. Types of surgery were divided into the following five groups: (1) general surgery, (2) iovascular surgery, (3) thoracic surgery, (4) obstetric, gynecologic, or urologic surgery, and (5) tic/orthopedic surgery or neurosurgery. In addition, liver and kidney transplantations were ded in the general surgery group, lung and heart-lung transplantations were included in the acic surgery group, and heart transplantation was included in the cardiovascular surgery group.
), and then converted to the equivalent in U.S. dollars ($) based on the exchange rate of 1060 won = 1 dollar to express the unit of costs in dollars.

Measurement and Outcome
Demographic information (age, body mass index, and sex), preoperative comorbidities, and surgery-related information of the patients were extracted. The collected preoperative comorbidity information included hypertension, diabetes mellitus, history of ischemic heart disease and cerebrovascular disease, liver disease (hepatitis, liver cirrhosis, hepatocellular carcinoma), and cancer. Types of surgery were divided into the following five groups: (1) general surgery, (2) cardiovascular surgery, (3) thoracic surgery, (4) obstetric, gynecologic, or urologic surgery, and (5) plastic/orthopedic surgery or neurosurgery. In addition, liver and kidney transplantations were included in the general surgery group, lung and heart-lung transplantations were included in the thoracic surgery group, and heart transplantation was included in the cardiovascular surgery group. All medical records were extracted by a medical record technician who was blinded to the purpose of the study.
The primary outcome of this study was to examine the association between perioperative FB and total and daily hospital costs. We also analyzed the effect of patients' out-of-pocket medical costs on overall costs.

Statistical Analysis
Continuous and categorical variables of the patients' baseline characteristics were expressed as mean with standard deviation (SD) and number with percentage, respectively. First, a restricted cubic spline was used to characterize the pattern of change in total hospital cost ($) and daily cost ($) according to FB (%) increase. Next, we conducted univariable linear regression analyses to examine the independent association of each variable with total costs and daily costs. From univariable linear regression models, variables with p < 0.1 were included as covariates in multivariable linear regression analyses. The potential presence of multicollinearity among each FB (%) (POD 0, POD 0-1, POD 0-2, and POD 0-3) was considered, and four multivariable linear regression models were developed for each FB. Using the above method, we performed a multivariable linear regression analysis according to the five surgery types for an additional subgroup analysis. All data were analyzed using IBM SPSS version 24.0 (IBM Corp., Armonk, NY, USA), and statistical significance was assumed at p < 0.05.

Results
In total, 7481 patients underwent major surgery that exceeded two hours and with an EBL of more than 500 mL from January 2010 to December 2017. Of these, 164 patients under 19 years of age and 307 patients with incomplete or missing medical records were excluded from the analysis. Medical records of the final sample of 7010 patients were analyzed. Patients' FB (%) in POD 0, 0-1, 0-2, and 0-3 were 2.6 (3.1), 4.1 (3.1), 4.7 (5.0), and 5.3 (6.1), respectively ( Figure 1). Baseline characteristics of the patients are shown in Table 1. The total and daily costs incurred by patients who underwent major surgery were $19,156.9 ($22,633.9) and $1198.6 (904.1), respectively. Of the total cost, non-coverage by the NHIS was 35.3% (15.9%).
All medical records were extracted by a medical record technician who was blinded to the purpose of the study.
The primary outcome of this study was to examine the association between perioperative FB and total and daily hospital costs. We also analyzed the effect of patients' out-of-pocket medical costs on overall costs.

Statistical Analysis
Continuous and categorical variables of the patients' baseline characteristics were expressed as mean with standard deviation (SD) and number with percentage, respectively. First, a restricted cubic spline was used to characterize the pattern of change in total hospital cost ($) and daily cost ($) according to FB (%) increase. Next, we conducted univariable linear regression analyses to examine the independent association of each variable with total costs and daily costs. From univariable linear regression models, variables with p < 0.1 were included as covariates in multivariable linear regression analyses. The potential presence of multicollinearity among each FB (%) (POD 0, POD 0-1, POD 0-2, and POD 0-3) was considered, and four multivariable linear regression models were developed for each FB. Using the above method, we performed a multivariable linear regression analysis according to the five surgery types for an additional subgroup analysis. All data were analyzed using IBM SPSS version 24.0 (IBM Corp., Armonk, NY, USA), and statistical significance was assumed at p < 0.05.

Results
In total, 7481 patients underwent major surgery that exceeded two hours and with an EBL of more than 500 mL from January 2010 to December 2017. Of these, 164 patients under 19 years of age and 307 patients with incomplete or missing medical records were excluded from the analysis. Medical records of the final sample of 7010 patients were analyzed. Patients' FB (%) in POD 0, 0-1, 0-2, and 0-3 were 2.6 (3.1), 4.1 (3.1), 4.7 (5.0), and 5.3 (6.1), respectively (Figure 1). Baseline characteristics of the patients are shown in Table 1. The total and daily costs incurred by patients who underwent major surgery were $19,156.9 ($22,633.9) and $1198.6 (904.1), respectively. Of the total cost, non-coverage by the NHIS was 35.3% (15.9%).

Total and Daily Costs According to FB (%) in POD 0-3
The patterns of change in total and daily costs according to FB (%) in POD 0-3 are shown in Figure 2A,B. Total and daily costs increased as FB in POD 0-3 increased. The results of univariable linear regression analyses are shown in Table 2, while the results of the multivariable linear regression analysis, after controlling for variables selected from the univariable linear regression model, are shown in Table 3      Variables with p < 0.1 were included multivariate linear regression analysis in Table 3. OG, obstetrics and gynecologic; PS, plastic surgery; OS, orthopedic surgery; NS, neurosurgery; FB, fluid balance; POD, postoperative day; NHIS, National Health Insurance Service. All covariates of p < 0.1 in each univariable linear regression models (Table 2) were included in four multivariable linear regression analysis (a-d). FB (%) in POD 0, 0-1, 0-2. And 0-3 were included in each different multivariable linear regression models (a-d) to avoid interactions between variables regarding FB (%). FB, fluid balance; NHIS, National Health Insurance Service.

Subgroup Analysis According to Type of Surgery
The results of multivariable linear regression analyses of total cost ($) according to FB in POD 0-3 by each type of surgery are shown in Table 4. As FB increased, the total cost increased for all surgery types (coefficient > 0, p < 0.001), and this association was the highest in the thoracic surgery group (coefficient > 2000), followed by the cardiovascular surgery group (coefficient > 600, p < 0.001). Table 4. Multivariable linear regression analysis for total cost ($) in patients according to major surgical procedures.

Discussion
Our study demonstrated that there is a significant positive association between perioperative positive FB and total and daily costs. Increases in costs resulted in relatively higher FB (%) in POD 0 (24 h) and POD 0-1 (48 h) than in POD 0-2 (72 h) and POD 0-3 (96 h). In addition, the strongest association was observed in patients who underwent relatively more expensive and invasive cardiothoracic surgery. As improving surgical quality and reducing hospital costs are two important challenges facing hospitals and the government [14], our study's findings are important because we revealed the association between perioperative positive FB and hospital costs of a surgical population. Moreover, it is worth noting that we used weight-based FB that considers patients' weight at the time of admission in our analysis to show its association with hospital costs.
Furthermore, the results of this study may be important from the perspective of enhanced recovery after surgery (ERAS) [15]. There is controversy regarding the optimal fluid management strategy in the perioperative period, and the target of achieving zero FB in the perioperative period is usually recommended for ERAS [16]. In addition, the implementation of ERAS protocol can reduce hospital costs after pancreaticoduodenectomy [17] and colorectal surgery [18]. Regarding this point, our finding that positive FB is associated with an increase in hospital costs after major surgery is consistent with the findings of previous studies [16][17][18]. However, we did not consider goal-directed fluid therapy (GDFT), because our institution did not use any fluid management protocol regarding GDFT during the study period. Considering that GDFT is known to reduce length of hospitalization after major surgery [19], it can also help reduce hospital costs. Therefore, it is necessary to conduct further research on the relationship between GDFT and surgery costs.
We hypothesized that positive FB may be associated with increased costs of a surgical population based on findings from previous studies. First, perioperative FB has been reported to be associated with increased postoperative complications [6], which results in higher hospital costs [9,10]. Thus, we hypothesized that perioperative FB would be positively associated with hospital costs, which was effectively demonstrated in our study. Second, surgical bleeding, which is one of the major causes of fluid imbalance during surgery, may also affect hospital costs. Indeed, it has been reported that the length and costs of hospitalization increase as the severity of surgical bleeding increases during left-ventricular assist device surgery [20]. In summary, our study showed that FB may be a useful clinical index when implementing a clinical pathway to reduce hospital costs [21].
Our study is noteworthy in that it was conducted in Korea where the NHIS covers an average of 65% of all medical costs. In our study, the SD of the NHIS coverage was relatively small (15%), and since all patients had similar insurance coverage, our findings reflect the effect of positive FB, rather than that of individual insurance statuses, on medical costs. If our study had analyzed a population of patients with different insurance statuses, the results would have been greatly affected by the differences in each patient's insurance status. In fact, a cohort study in the United States reported that patients with relatively less insurance coverage are at greater risk of developing postoperative complications after colorectal cancer surgery [22], revealing insurance status to be an important factor that affects both the rate of complications and hospital costs. Thus, the fact that our study used medical records of patients with a similar insurance coverage under the NHIS adds significance to the association found between positive FB and hospital costs.
Another interesting finding of the present study is that as the percentage of non-coverage by the NHIS increased or, in other words, as the patients' out-of-pocket costs increased, the total costs independently decreased. As this result was obtained after controlling for the variables, including type of surgery, surgery time, age, and comorbidities, the "moral hazard" effect of health insurance may have influenced the results [23]. Moral hazards describe the excessive use of and expenditure on medical service by health consumers, or patients, when they have insurance coverage, and it is regarded as an important economic issue [24]. In the present study, there was a decreasing pattern in total and daily costs when the patients' out-of-pocket costs increased, which may be partly attributed to the moral hazard effect of health insurance. Further research is needed to explore this pattern.
Our study has several limitations. First, selection bias may have been present as a limitation of a retrospective observational study design. We tried to circumvent this limitation, however, by having a medical record technician, who was blinded to the purpose of the study, extract all medical records used for the study. Second, since it was a single-center study, the generalizability may be limited. Lastly, we did not consider fluid evaporation in FB calculation, given the heterogeneity of the surgical procedures. Despite these limitations, our study was the first to show that an increase in FB during the perioperative period is independently associated with hospital costs.

Conclusions
Our study showed that perioperative FB is positively associated with hospital costs of patients who underwent major surgery. Our study's findings are important because we revealed the association between perioperative positive FB and hospital costs of a surgical population. Future studies on the relationship between GDFT for surgery and hospital costs are necessary.

Conflicts of Interest:
The authors declare no conflict of interest.