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[Effect of maternal age on the success rate of in vitro fertilization. A comparison of human and animal experiment data].

From January 1981 to September 1986 863 patients have been treated by the technique of in vitro fertilization (IVF) at the department of Obstetrics and Gynaecology, University of Kiel. The classification of all patients in four different age groups reveals the fact, that there is no influence of maternal age on the number of patients having a follicular puncture. The rate of oocytes, fertilizations, and transfers is the same as well. Contrary to these findings there is a significant correlation between the age of a woman and the pregnancy rate after IVF. Women under 30 years of age have a pregnancy rate of 25.4% per transfer. This amount decreases to 17.7% in women of the age group 31 to 35 and further on to 9.7% in women between 36 and 40. Up till now, not one patient above the age of 40 has become pregnant after IVF at the University Clinic in Kiel. Therefore this technique is not recommended for patients above the age of 40.