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Microbiology of cystic fibrosis lung infections: themes and issues.

Microbial pathogens The susceptibility of patients with CF to pulmonary infections has been recognized since the first descriptions of the disease in the 1940s. One of the striking features of this susceptibility is that relatively few microbial pathogens are involved and that the significance of individual pathogens has evolved in parallel with improved patient management and longevity. The earliest microbiological study5 of postmortem cultures oflung tissue from 14 patients with CF, aged 1-40 months, yielded Staphylococcus aureus from 12, indicating the predominant role of this organism in very young patients in the early days of antibiotic therapy. Subsequently, Staph. aureus and Haemophilus influenzae became recognized as the most prevalent pathogens in children with CF. Today, the most prevalent lung infections in patients with