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Evaluation of Molecular Biomarkers in an Adolescent Chronic Restraint Stress Model of Depression

Chronic stress during sensitive developmental periods has been shown to be a risk factor for Major Depressive Disorder (MDD), a mood disorder that disproportionately affects women. In order to develop an animal model of MDD that addresses the impact of chronic stress during these periods, our lab modified previously published methods of adolescent chronic restraint stress (aCRS). Additionally, we sought to evaluate potential biomarkers of MDD in our aCRS model.