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Insulin-antagonistic effects of counterregulatory hormones: clinical and mechanistic aspects.

The counterregulatory hormones (catecholamines, glucagon, cortisol and growth hormone) can modulate the effects of insulin and, thus, influence the diabetic state under a variety of conditions. This can be beneficial to the diabetics when the hormones counteract the effect of an excessive insulin level, such as a hypoglycemia. However, under other situations they may be to a disadvantage since the glucose control deteriorates and the insulin requirements increase unpredictably.