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Acoustically enhanced Evans blue dye perfusion in neurological tissues.

In this study 1.58MHz therapeutic ultrasound was used to increase the perfusion of Evans blue dye (EBD) through neurological tissue-mimicking phantoms, equine brain and avian muscle tissues. We show a substantial increase in EBD perfusion into the sonicated tissue then can be achieved by diffusion alone. We are therefore able to reduce the time of delivery, the amount of EBD delivered and the local impact range. This could significantly increase the success of delivering actual therapeutic treatments and reduce systemic effects of chemotherapy