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HEADACHE IN A NON‐CLINIC TWIN POPULATION

A LARGE BODY OF medical literature has reported the frequency of migraine in the immediate relatives of patients suffering from this disorder and there have been several studies documenting the occurrence of migraine in several generations of families.1,2,3 It is well known on the other hand that large numbers of patients with migraine do not have a positive family history. There has been a wide divergence of opinion as to the place of genetic predisposition in the migraine syndrome. Twin studies with comparison of concordance between monozygotic and dizygotic twins have been carried out on apparently only four occasions. It has been stated that the concordance of migraine in monozygotic twins is strongly supportive of the presence of some genetic factor. The present study was designed to explore the headache history in detail in a large group of twins derived from non-clinic population. The concordance both of overall headache severity and of specific details of the headache history were then compared for monozygotic and dizygotic pairs.