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Serum-pharmacological study of DaBuYinWan pills on proliferation of T&B lymphocytes in autoimmune mice induced by Campylobacter Jejuni(CJ)

Objective To explore the effect of Da-Bu-Yin Wan(DBYW) on proliferation of T B lymphocytes in autoimmune mice induced by Campylobacter Jejuni with a method of serum-pharmacology study.Methods Healthy female ICR mice were divided into 8 groups at random as normal control group(N),model group(M),model control group(MC)and administering group(administration interval:30min、1 h、1.5 h、2 h、3 h).The mice were induced by Campylobacter Jejuni with Complete Freund's Adjuvant as autoimmune animal model except N group.From the fifteenth day after primary immunization,the administering group were given DBYW through gastric route in a dosage of 0.4 g/ml while MC group were given physiological saline.All the administration lasted for 10 days.After the last administration,blood samples were taken in 30min,1 h,1.5 h,2 h and 3 h respectively to detect the proliferation of T B lymphocytes.The curve of time-effect relationship was marked to show the drug efficacy.Results It was found that the proliferation of T B lymphocytes were markedly inhibited by the drug-containing serum taken at 1～1.5 hrs after the treatment(P0.01).Conclusion The drug-containing serum of mice taken at the time of l～1.5 hrs after ingestion of DBYW could regulate the proliferation of TB lymphocytes in autoimmune mice induced by Campylobacter Jejuni.