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Olmsted Syndrome: The Clinical Spectrum of Mutilating Palmoplantar Keratoderma

Abstract: Olmsted syndrome is a rare variety of transgredient palmoplantar keratoderma with an undefined inheritance pattern. It starts in the neonatal period or in childhood and has a progressive and extremely disabling course. We report two new, unrelated patients with Olmsted syndrome, one with the early signs and symptoms of the disorder, the other showing the full‐blown spectrum of the syndrome during a 30‐year follow‐up period.