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[Influence of the speed of spheronization on the physical properties and dissolution availability of theophylline minigranules prepared by extrusion-spheronization].

From the minigranules of the theophylline-based that prepared by extrusion-spheronization, the authors have envisaged the study of one of the parameters of operation (spheronizer speed) on the physical properties and lyoavailability of the active ingredient. It emerges that there is a clear influence of that parameters on the particle size distribution, the hardness, the friability, the density and the lyoavailability.