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Beneficial Effect of N- acetylcysteine on Certain Oxidative Stress Parameters during Reperfusion following Renal Ischemia in Rats

Background: A major internal threat to cellular homoeostasis arises from reactive oxygen species (ROS) formed as a result of normal physiological and metabolic processes that are essential to life which are overcome by the presence of body's natural antioxidant system. In the present study we evaluated the efficacy of N-acetylcysteine (NAC) against the damage caused by oxygen free radical (OFR) during reperfusion following renal ischemia using biochemical parameters. Wistar Albino rats were used in the present study. Animals were subjected to 60 minutes of unilateral ischemia followed by 10 minutes of reperfusion keeping the contralateral kidney intact. N- acetylcysteine was administered just before the reperfusion period. Biochemical parameters such as malnoaldehyde (MDA), glutathione (GSH) and su- peroxide dismutase (SOD) were estimated from the tissue homogenate to assess the degree of damage. Results: The tissue lipid peroxidation, (MDA) was significantly enhanced but simultaneous decrease in GSH, SOD in reperfusion period when compared to control (p<0.0001). These results indicate that free radical formation involves in renal injury. Administration of NAC could reverse the alterations (p<0.0001) Conclusion: The above results suggest that NAC has protective effect against damage caused by oxy- gen free radicals.