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Modulatory Influence of Abutilon Indicum Leaves on Hepatic Antioxidant Status and Lipid Peroxidation against Alcohol-Induced Liver Damage in Rats

Summary To evaluate the modulatory influence of ethanol extract of Abutilon indicum leaves on hepatic antioxidant status and lipid peroxidation against alcohol-induced liver damage in rats. The 30% alcohol (3.0 ml/150 g b wt/day, PO, for 21 days) treated rats have been more susceptible to peroxidative damage as measured by thiobarbituic acid reactive species. After the 30% alcohol induction to rats, the concentration of lipid peroxidation was significantly higher in liver and serum, alongwith concomitant significant decrease in the levels of enzymic and non enzymic antioxidants such as SOD (Superoxide dismutase), CAT (Catalase), GPx (glutathione peroxidase), GR (glutathione reductase), GST (glutathione-Stransferase), GSH (glutathione), vitamin C, vitamin E, Ceruloplasmin and β-carotene were significantly (P<0.001) lower in liver and serum of 30% alcohol treated rats compared with normal controls. When these rats received A. indicum leaves extract, at the doses of 100 and 200 mg/kg b wt/day, PO, for 21 days, peroxidative damage was minimal in both liver and serum, dose-dependently alongwith effectively inducing the antioxidant potential in alcohol treated rats. In conclusion, the increased peroxidative damage in liver is likely to be associated with alcohol induction pathology, which could be reduced by A. indicum leaves extract by enhancing the antioxidant potential through free radical scavenging activity due to its some flavonoids and micronutrients.