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Hepatosplenomegaly and Bone Marrow Fibrosis in Primary Myelofibrosis: A Case Report

Primary myelofibrosis is a spontaneous neoplastic disorder of the bone marrow that results in fibrosis and disruption of myeloid cell lines. Progression of this disease results in marrow fibrosis and production compensation in other organs. In this case report, a 69-year-old woman with JAK2+ myelofibrosis presents with left sided abdominal pain and gastrointestinal complications likely due to her disease. We review images demonstrating hepatosplenomegaly and osteosclerosis, both common findings in patients with myelofibrosis. We also noted that although a rare finding, extramedullary hematopoiesis may occur in the bowel and can present with symptoms of gastrointestinal complications. Further examination would be required to confirm the suspicion in this patient.