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Intraluminal ~(192)ir brachytherapy for local advanced hilar duck carcinoma with external radiation

Objective To assess the effect of intraluminal 192 ir brachytherapy for local advanced hilar bile duck cancer after palliative biliary drainage.Methods The patients with advanced hilar cholangiocarcinoma underwent laparotomy and had their tumor resected as much as possible.After establishment of bile drainage using a U tube intraluminal 192 Ir was placed.The reference dose was calculated at 12mm from the source varied from 24 to 32 Gy in 3 infractions.Patients received external radiation from 50 to 60 Gy over 5 weeks.Results the survival time of this patient was 6～26 months with a median of 11.2 months.The 1,2,3 and 4 year survival rates for the whole group were 46.2%(6/13),44.4%(4/9),33.3%(2/6),and 33.3%(1/3).There wasn't any severe side effects.Conclusion The palliative bile drainage followed by intraluminal brachytherapy could improve the survival quality of life in patients with local advanced hilar bile duct catcinoma.