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Synthesis, Design and Biological Evaluation of Antibacterial Activity of Novel Mixed Metal Complexes Derived from Benzoimidazolphenylethanamine and 6-Amino-N,N-dimethyluracil



Benzoimidazolphenylethanamine (BPE) was synthesized through the condensation reaction
of 1,2-phenyldiamine and L-phenylalanine. The new complexes were prepared from the reaction of 6-
amino-N,N-dimethyluracil (ADU), benzoimidazolphenylethanamine and Cadmium (II), Tin (II), Copper
(II) and Nickel (II) metal respectively. All new hybrid complexes were fully characterized by spectroscopic
data of FTIR, UV-Visible electronic absorption, thermal analysis, X-ray powder diffraction
studies and mass spectroscopy. Spectra analyses of the hybrid metal complexes showed the tetrahedral
coordination of the ligands to the metal ions via the nitrogen atoms. The in vitro antibacterial activities
of the hybrid complexes were assayed against four bacterial isolates namely, Micrococcus luteus,
Staphylococcus aureus as Gram-positive bacteria, Pseudomonas aeruginosa and Escherichia coli as
Gram-negative bacteria using the agar well diffusion method. Most of the tested isolates were sensitive
to most metal hybrid complexes. The drug-likeness and bioactivity properties were calculated using
Molinspiration Cheminformatics software.
