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Abstract 18099: Emergency Department Trauma Patients Requiring Platelet Transfusions Display Early Platelet Dysfunction

Introduction: Platelets contribute to hemostasis by rapidly sticking, aggregating, and contracting at wounds to stabilize blood clots. There is evidence that severe trauma with blood loss can render platelets dysfunctional, which is associated with increased mortality. However, this platelet dysfunction has not been well described. Hypothesis: We hypothesize that there is significant platelet dysfunction present in those trauma patients requiring urgent platelet transfusion for treatment of bleeding. Methods: We conducted a prospective observational trial of trauma patients presenting to a U.S. Level I trauma center. Subjects were enrolled and blood samples collected for blood chemistries, cell counts, coagulation, clot formation by rotational thromboelastometry (ROTEM), platelet aggregation after activation by thrombin, ADP, arachidonic acid, collagen, and ristocetin, and platelet contractile force by mechanical shear activation. Subject demographics, blood products transfused, and mortality were abstrac...