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Follow-up of infants with single umbilical artery.

Of 39,773 white and black consecutive single births, 344 (0.9%) had single umbilical artery (SUA). The incidence was higher in whites (1.2%) than in blacks (0.5%). Despite high mortality in infants with SUA (14.0%) the incidence was still 0.7% among surviving infants. Associated malformations were present in 19 of 36 dead infants with SUA, or 52.8%, and in 11 of 266 SUA survivors, or 4.1%. Cardiovascular and genitourinary anomalies were not higher in dead infants with SUA compared to all dead malformed infants. A follow-up study of infants up to 4 years of age was undertaken, comparing 266 SUA survivors with 798 matched controls. Among malformations found in survivors, only inguinal hernia was significantly higher in SUA children compared to controls. The incidences of other specific abnormal conditions were not significantly different in the two groups. The mean values of body weight, body length, and head circumference at 4 months, 1 year, and 4 years of age, were almost equal in the two groups, as were the mental and motor scores at 8 months and the I.Q. at 4 years of age.