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Prevalence and awareness of sickle cell hemoglobin in a military population. Determination by a rapid screening method.

On a prospective study, 1,000 Negro military recruits were screened with a new rapid differential solubility test for sickle cell hemoglobin. A total of 75 had positive screening tests: 73 had sickle cell trait, 1 had sickle cell-hemoglobin C disease, and 1 had sickle-thalassemia disease. There were no false-positive or false-negatives detected. In only five of the 150 individuals questioned was there any awareness of sickle cell states. This test is rapid and reliable and routine screening of the Negro population accompanied by education and genetic counseling is recommended.