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Cognitive decline at middle age

There is no disease‐modifying treatment for Alzheimer’s Disease and Related Dementia (ADRD). However, its pathology may occur 20 years earlier than its symptoms. Therefore, understanding cognitive decline at middle age, which might be the starting point of dementia, may be particularly important for preventing or delaying the onset of dementia. This study quantified the population with fast rates of cognitive decline at middle age, explored the distribution of cognitive trajectories, and investigated demographic, health, and socioeconomic factors associated with cognitive deterioration for Americans.