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Pitfalls in the use of in vitro survival curves for the determination of tumour cell survival with fractionated doses.

Ellis (1974) and Habermalz and Fischer (1976) have suggested that “high-individual-dose-fractionation schedules” would be expected to give better results in the therapy of malignant melanoma based on the large shoulders exhibited by the survival curves of some malignant melanoma cell lines (Dewey, 1971 ; Barranco et al., 1971). It has already been pointed out that there is no consensus regarding a large shoulder for malignant melanoma cells (Zeitz and Silagi, 1977).