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[The changes of plasma calcitonin gene-related peptide level in women with normal pregnancy and pregnancy induced hypertension].

OBJECTIVE
To study the change of calcitonin gene-related peptide (CGRP) concentrations in maternal plasma of the normal pregnant women and patients with pregnancy induced hypertension (PIH) and relationship with CGRP and pathogenesis of PIH.


METHODS
The plasma levels of CGRP in 59 cases of normal pregnant women (normal pregnancy group), 57 cases of PIH (PIH group), and 10 cases of nonpregnant women (control group) were determined with a sensitive radioimmunoassay.


RESULTS
Plasma CGRP levels in normal pregnancy group increased with advance for the gestational week, reached the peak value (76.84 +/- 27.75 ng/L) in late trimester; plasma CGRP levels in PIH group decreased with series degree of PIH, levels of CGRP in moderate (49.76 +/- 23.11 ng/L) and severe PIH (46.35 +/- 22.32 ng/L) were significantly lower than that in mild PIH (71.28 +/- 21.98 ng/L) and the normal late pregnancy, the differences were significant (P < 0.005). There was no correlation between CGRP levels and the mean arterial pressure (MAP).


CONCLUSIONS
The change of CGRP may play an important role in the pathogenic mechanism of PIH.