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Anaphylactoid reaction after injection of anti‐rhesus‐D‐hyperimmunoglobulin

difference that is highly significant. Thus, the percentage of subjects complaining of symptoms suggesting atopy is higher in females. In contrast, the percentage of subjects with both a history of hay fever and a positive skin test to grass pollens (Table 2) is comparable in both sexes. Likewise, the percentage of subjects with a history of asthma, hay fever and childhood dermatitis, and at least a positive skin test, is very similar in men and women (Table 2). Thus, if atopy is defined according to skin tests to common allergens, its prevalence is similar in both genders. The explanation for this excess ofreported symptoms in females is unclear. It is not related to the age distribution of men and women in our studied population, which was very similar (mean age in men: 39-8 ± 1 3 1 , mean age in women: 40-1 + 13-3). Another hypothesis could have been that female interviewees could be more prone to provide positive answers to female interviewers. Indeed, 11 out of our 17 interviewers were female. However, the same results were also observed in data collected by male interviewers. In the literature, so far, epidemiological surveys [1, 2] have provided similar estimates of allergic symptoms in adults of both sexes. However, Freidhoff et al. [3] stated that if the proportion of men and women reporting allergy was similar, in people reporting allergy, the relative proportion (mean: women) of positive skin tests to at least one environmental allergen was 2 :1 . These data, together with ours, suggest that atopy should be defined according to biological criteria of IgE-mediated responsiveness rather than according to symptoms.