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THU0142 Prediction of Non-Adherence in Patients with Rheumatoid Arthritis

Background Rheumatoid arthritis (RA) is a very prevalent autoimmune disease. Adherence to prescribed drug is important to prevent irreversible joint damage. Unfortunately, adherence in this population is low, estimated to 60-70%. As a result, an approach by screening non-adherence potential behavior in patients would be valuable. Although a number of self-report medication adherence questionnaires exist, only the “Compliance Questionnaire on Rheumatology” (CQR) has been validated in english in patients with inflammatory arthropathies. The aim of this study is to evaluate the validity of a french version of the CQR and assess its possible use as a adherence screening tool. Objectives Establish the validity of the translated questionnaire in french and evaluate the possible predicting role of the CQR (Compliance questionnaire on rheumatology) for patients suffering from Rheumatoid Arthritis. Explore the validity of a short version of the CQR. Methods We conducted a longitudinal descriptive study. The inclusion criteria were: RA diagnosis, age over 18 years, RA duration≥1 year, and RA treatment for at least the previous six months (DMARD and/or biologic agent). Adherence was measured in two different methods: 1) patients completed the French version of the CQR questionnaire during a medical visit at the Institut de Rhumatologie de Montréal between November 11th and December 17th, 2013 and 2) the pharmaceutical profile for the six months preceding to the medical visit was obtained by contacting the individual pharmacist. The medical possession ratio (MPR) was then calculated for each patient, and compared to the result of the CQR questionnaire. Results 160 patients with rheumatoid arthritis were included in this study. All of them gave written informed consent. The preliminary results show an adherence rate to DMARD of 79.1%, which is slightly higher than the literature. The rate of adherence to hydroxychloroquine (HCQ) and methotrexate (MTX) are similar (80.6% vs 80.0%). The participants seem to be more adherent to oral medication compared to subcutaneous (83.8% vs 71.9%). Adherence calculated by the medical possession ratio (MPR) show that non-adherent patients correlate with a poorer result to their CQR questionnaire. The short version gave similar results compared to the original CQR. Conclusions The French version of the CQR questionnaire could become a useful tool to evaluate adherence in rheumatoid arthritis population. Further analysis and results are pending. Disclosure of Interest None declared