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A Novel Gene Required for Rhamnose-Glucose Polysaccharide Synthesis in Streptococcus mutans

ABSTRACT Gene rgpG is required for biosynthesis of rhamnose-glucose polysaccharide (RGP) in Streptococcus mutans. Its deduced amino acid sequence had similarity to WecA, which initiates syntheses of enterobacterial common antigen and some O antigens in Escherichia coli. Gene rgpGcomplemented a wecA mutation of E. coli, suggesting that rgpG may function similarly in RGP synthesis.