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Abstract 9: CONDITIONAL NEURAL CREST CELL ABLATION TO INTERROGATE CRANIOFACIAL REGENERATION IN VERTEBRATE MODEL

Background: It has long been hypothesized that neural crest (NC) stem or progenitor cells exist and they are able to undergo self-renewal, proliferation and multi-lineage differentiation. Most of the NC stem-like properties described to date were gleaned from in vitro assays, such as neural tube explants. In order to generate an in vivo regeneration assay, we develped a lineage-restricted inducible transgenic model where NC cells can be selectively ablated and their regenerative potential be assessed.