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THERAPEUTIC EFFECT OF LEUKOTRIENE RECEPTOR ANTAGONIST MONTELUKAST IN TREATMENT OF RESPIRATORY TRACT MYCOPLASMAL INFECTIONS IN CHILDREN

Objective Mycoplasma pneumoniae is the main pathogen in upper respiratory tract infection among children,and the morbidity is also high.In addition to causing respiratory mucosa,it can act as an allergen to cause airway hyperresponsiveness,result in long-range cough,even trigger or develop asthma[1].Leukotriene receptor antagonist montelukast can block mycoplasma pneumoniae that stimulates the inflammatory response of the respiratory tract as an allergen after infection,and lower airway hyperresponsiveness.Methods Totally 760 children infected with mycoplasma pneumoniae from March 2006 to February 2008 in respiratory disease department of our hospital were selected to randomly assign into the observation group and the control group.Both groups took conventional anti-mycoplasma therapy,but the observation group simultaneously took montelukast for 4 days and 7 days,then their cough conditions were observed and compared.Results Mycoplasma pneumoniae infection after application of conventional anti-mycoplasma therapy(azithromycin) and symptomatic treatment,supplemented by montelukast special treatment,the symptom remission of cough in the observation group was significantly better than that of the control group.Conclusions Leukotriene receptor antagonist can block mycoplasma pneumoniae that stimulates the inflammatory response of the respiratory tract as an allergen after infection,lower airway hyperresponsiveness,reduce mucus secretion,ease bronchial spasm,and shorten the duration of cough.