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A spatial analysis of health and pharmaceutical firm survival

ABSTRACT The presence of knowledge spillovers and shared human capital is at the heart of the Marhall–Arrow–Romer externalities hypothesis. Most of the earlier empirical contributions on knowledge externalities; however, considered data aggregated at a regional level so that conclusions are based on the arbitrary definition of jurisdictional spatial units: this is the essence of the so-called modifiable areal unit problem. A second limitation of these studies is constituted by the fact that, somewhat surprisingly, while concentrating on the effects of agglomeration on firm creation and growth, the literature has, conversely, largely ignored its effects on firm survival. The present paper aims at contributing to the existing literature by answering to some of the open methodological questions reconciling the literature of Cox proportional hazards model with that on point pattern and thus capturing the true nature of spatial information. We also present some empirical results based on Italian firm demography data collected and managed by the Italian National Institute of Statistics (ISTAT).