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Polymorphisms of the tumour necrosis factor‐α gene, coronary heart disease and obesity

Tumour necrosis factor‐α (TNF‐α) is a cytokine that has multiple functions. Through its effects on lipid metabolism, coagulation, insulin resistance and endothelial function, TNF‐α could be involved in cardiovascular pathophysiology. Given this possibility, we hypothesized that polymorphisms of the TNF‐α gene might be associated with a predisposition to coronary heart disease (CHD).