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Vildagliptin-loaded gellan gum mucoadhesive beads for sustained drug delivery: design, optimisation and evaluation

ABSTRACT The work investigates the design and optimisation of vildagliptin (VLG)-loaded gellan gum beads for sustained release delivery. The VLG beads were prepared by the ionotropic-gelation method. A response surface methodology was used to optimised the effects of independent variables such as gellan gum to sodium alginate ratio ( ) and concentration of CaCl2 ( %) on dependent variables such as entrapment efficiency (EE) ( %) and drug release (DR) ( %). The prepared beads were characterised by employing EE, bead diameter, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM) and DR. The values of %EE were in ranges of 76.20–91.25% and %DR was in ranges of 76.33 ± 1.64–85.12 ± 1.38% for duration of 12 hours. The optimised beads showed pH-dependent swelling and good mucoadhesivity. The VLG-loaded SA-GG beads were successfully prepared and seem to be promising for sustained release action for 12 hours duration.