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Body Fat and Fatty Acid Synthesis in Five Lines of Mice Selected for Growth Rate 1

Summary Two lines of mice (O10 and C10) were derived from an ICR strain. The O10 mice weighed 52 g and contained 15.5% fat while the C10 mice weighed 36 g and contained 8.3% fat at 14 weeks of age. At this time, the O10 mice exhibited hyperglycemia and an increased rate of hepatic fatty acid synthesis when compared with the C10 mice. Although three other lines of mice (H6, C2, and L6) derived by reciprocally crossing CAF1 and AKD2F1 mice exhibited marked differences in body weight at 14 weeks of age (H6 = 37 g; C2 = 29 g; and L = 22 g), the percentage of body fat, blood glucose values, and in vitro rates of fatty acid synthesis in liver and adipose tissue were similar in these mice.