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Can an Immune Checkpoint Inhibitor (Sometimes) Make Things Worse?

Champiat and colleagues suggest that a small subset of patients at their center treated with PD1/PDL1 inhibitors appear to exhibit hyperprogression of disease. This commentary goes over some limitations in their preliminary analysis, a possible mechanism to explain the phenomenon, and a means by which other investigators can attempt to validate and further characterize these results. Clin Cancer Res; 23(8); 1879–81. ©2017 AACR. See related article by Champiat et al., p. 1920