{'fraction_non_alphanumeric': 0.018746338605741066, 'fraction_numerical': 0.008201523140011716, 'mean_word_length': 5.594594594594595, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
THE USE OF IMMUNOLOGICAL INDICATORS IN ORDER TO FORM AN IMMUNOCOMPROMISED GROUP FOR VACCINATION AGAINST PNEUMOCOCCAL INFECTION

Abstract: Pneumococci (Streptococcus pneumoniae) are one of the leading causes of morbidity and mortality among people over 60 years of age and workers in some professional groups. According to the medical literature, the frequency of invasive forms of pneumococcal infection among people of working age is 3.8 per 100,000 population. Increased susceptibility to colonization of the respiratory tract and subsequent morbidity may be due to concomitant pathology, exposure to immunocompromising, including harmful production factors. It should be noted that the source of the pathogen is not only sick people, but also healthy carriers. The level of asymptomatic colonization in the adult population is 5-7%, and in families with children increases to 30%. Vaccination is a way to effectively prevent respiratory diseases caused by this infection. The purpose of our study is to substantiate immunological indications for the formation of immunocompromised groups among workers exposed to the aerogenic factor at work for subsequent vaccination against pneumococcal infection. Results: It has been shown that low bactericidal activity of neutrophils (NBT-test) and a high level of secretory immunoglobulin can be used as a marker of immunodeficiency in workers of a ferrous metallurgy enterprise. When a doctor assesses the immune status of workers, he needs to take into account the presence of diseases that are part of the groups of immunological syndrome complexes (infectious-inflammatory, autoimmune, allergic, immunoproliferative) and the composition of industrial aerosols