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APOBEC3A_B Fusion Hybrid Gene

A fusion gene (~10 kb) that results from the deletion of approximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent APOBEC3B gene. The deletion hybrid is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. This mutation results in an APOBEC3B null phenotype, which would impact antiretroviral defense processes, and may be associated with an increased risk of breast carcinoma and other neoplastic diseases.