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Astrocyte calcium signaling: Interplay between structural and dynamical patterns.

Inspired by calcium activity in astrocytes, which is different in the cell body and thick branches on the one hand and thin branchlets and leaflets on the other hand, we formulate a concept of spatially partitioned oscillators. These are inhomogeneous media with regions having different excitability properties, with a global dynamics governed by spatial configuration of such regions. Due to a high surface-to-volume ratio, calcium dynamics in astrocytic leaflets is dominated by transmembrane currents, while somatic calcium dynamics relies on exchange with intracellular stores, mediated by IP 3 , which is in turn synthesized in the space nearby the plasma membrane. Reciprocal coupling via diffusion of calcium and IP 3 between the two regions makes the spatial configuration an essential contributor to overall dynamics. Due to these features, the mechanisms governing the pattern formation of calcium dynamics differ from classical excitable systems with noise or from networks of clustered oscillators. We show how geometrical inhomogeneity can play an ordering role allowing for stable scenarios for calcium wave initiation and propagation.