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[Effects of acupuncture on serum IL-4, IL-6 and IL-10 in patients with allergic rhinitis].

OBJECTIVE
To observe and compare the clinical efficacy on allergic rhinitis and the impacts on the expression of serum interleukin-4 (IL-4), interleukin-6 (IL-6) and interleukin-10 (IL-10) between intranasal acupuncture and routine acupuncture.


METHODS
According to the random number table method, 80 patients of allergic rhinitis were divided into an intranasal acupuncture group (40 cases) and a routine acupuncture group (40 cases). In the intranasal acupuncture group, Neiyingxiang (EX-HN9) and Biqiu (Extra) were punctured. In the routine acupuncture group, Yingxiang (LI20, bilateral), Yintang (GV24~+), Shangxing (GV23) and Hegu (LI4, bilateral) were stimulated. In both groups, the treatment was given once daily, for 2 weeks. The total nasal symptom score (TNSS), the total non-nasal symptom score (TNNSS) and rhinoconjunctivitis quality of life questionnaire (RQLQ) score were observed before and after treatment; the contents of IL-4, IL-6 and IL-10 in serum were determined by enzyme linked immunosorbent assay.


RESULTS
Compared with the values before the treatment, the scores of TNSS, TNNSS and RQLQ, as well as the contents of serum IL-4 and IL-6 were all decreased after treatment in the two groups (P<0.05), while the content of serum IL-10 was increased (P<0.05). After the treatment, in comparison with the routine acupuncture group, the scores of TNSS, TNNSS and RQLQ, as well as the contents of serum IL-4 and IL-6 were decreased and IL-10 was increased significantly in the intranasal acupuncture group (P<0.05). The total effective rate of the intranasal acupuncture group was 90% (36/40), better than 80% (32/40) of the routine acupuncture group (P<0.05).


CONCLUSION
Intranasal acupuncture can effectively relieve the symptoms of allergic rhinitis, and improve the patient's quality of life, and has a better curative effect than routine acupuncture.