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Different Epidermal Cell Kinetic Effects of Hydroxyurea When Injected At Two Different Times of the Day

Circadian rhythms in epidermal basal cell‐cycle progression in hairless mouse skin have been repeatedly demonstrated. A dose of 10 mg/animal hydroxyurea (HU), given to inhibit DNA synthesis was injected intraperitoneally to two groups of hairless mice. One group was injected at 10.00 hours MET, when the cell‐cycle progression and cell division rate are relatively high, and another group was injected at 20.00 hours, when the same variables are at minimum values. Various cell kinetic methods—[3H]TdR autoradiography, DNA flow cytometry and the stathmokinetic method (Colcemid)—were used to study HU‐induced alterations in cell kinetics.