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Simple and Inexpensive Methods Development for the estimation of Tamsulosin Hydrochloride as a single component from Its Solid Dosage Forms by Visible Spectrophotometry

Tamsulosin hydrochloride (TAM) is an uroselective alpha1A-adrenergic receptor antagonist which is used in benign prostatic hyperplasia (BPH).The drug is official in European Pharmacopoeia. Two direct, simple and sensitive visible spectrophotometric methods are described for the assay of tamsulosin hydrochloride in pure and solid dosage forms. The first method M1 is based on the formation of yellowish brown colored species by the drug with Folin reagent and exhibits absorption maxima at 440 nm. Second method (M2) is based on the formation of purple red colored species with sodium nitroprusside–acetaldehyde reagent exhibiting maximum absorption at 560 nm. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges (16-48) µg/ml for method M1, and (8.0-24) µg/ml for method M2 respectively. The proposed methods are applied to commercial available tablets and the results are statistically compared with those obtained by the UV reference method and validated by recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of the tamsulosin hydrochloride in the presence of other ingredients that are usually present in dosage forms. These methods offer the advantages of rapidity, simplicity and sensitivity and normal cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.