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Update in the diagnosis and management of heparin-induced thrombocytopenia.

AC HIT occurs in 0.2–5% of adults who are treated with heparin, depending on the patient population and the type and duration of heparin exposure. Surgical patients have a higher risk of HIT than medical patients. Unfractionated heparin is associated with roughly a 10-fold greater risk of HIT than low-molecular-weight heparin. Courses of heparin therapy of 5 or more consecutive days carry a higher risk than briefer exposures.