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[Immunoregulatory effects of monomer T4 from Tripterygium wilfordii hook. I. Immunoregulatory effects of T4 on NK activity of mouse splenocytes].

Effects of monomer T4 on NK activity of mouse splenocytes were determined both in vitro and in vivo by means of a classical I-UdR release assay. The results showed that monomer T4 exhibited dose-dependent double-regulatory inhibiting enhancing effects, ie, T4 of low dosage enhanced the percentage of NK cytotoxicity and LU numbers, while a high dosage showed dose-dependent inhibition. The double-regulatory effects of monomer T4 might be important for evaluation of the therapeutic effects of Tripterygium wilfordii Hook in future clinical practice.