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Antibody response to Pr-beta-HCG-TT vaccine in human subjects.


 Antibody response to processed beta human chorionic gonadotropin tetanus toxoid vaccine (Pr-beta-HCG-TT) was investigated in 4 human subjects who were in reproductive age and of proven fertility and had undergone tubal ligations. The subjects responded by producing detectable anti-HCG antibodies after a lag period of 6-8 weeks and plateau levels at about 5 months after primary immunization with the vaccine. Anti-HCG antibody titers were still high in 3 subjects after nearly 11 months of immunization. The titers declined to near 0 after 16 months in 1 subject indicating the reversibility of antibody response with this vaccine. The antibodies reacted immunologically with the HCG molecule and were competent to neutralize the biological activity of HCG in the radioligand receptor assay.
