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LIPOPROTEIN BIOSYNTHESIS AND METABOLISM *

It is generally accepted that the protein and some of the lipid components of the plasma lipoproteins are synthesized in the parenchymal cells of the liver and the absorptive cells of the small intestine. Most of the detailed research in this area has been performed in rats, but some important information has been obtained in humans as well. The sites of removal of lipoprotein components are for the most part, uncertain. Major attention in recent years has attached to the role of the liver in the “terminal” catabolism of lipoproteins. The mechanisms of biosynthesis and terminal catabolism have also received attention. This review summarizes some recent research on the sites and mechanisms of biosynthesis and terminal catabolism of lipoproteins in rats and humans. FIGURE 1 summarizes some major features of lipoprotein-lipid metabolism and transport.