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Introduction Evolving data implicate the synapse in the pathogenesis of ischemic brain injury and stroke

Evolving data implicate the synapse in the pathogenesis of ischemic brain injury and stroke. Ischemic conditions in the brain induce profound changes in synaptic function and synaptic morphology, which may account for early functional loss and deficits observed following stroke. A better understanding of the effects of ischemia on the synapse may help guide novel therapeutic approaches to reduce brain damage and aid in the recovery of function following a stroke.