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Quantitative aspects of the binding of folic acid by folate antiserum.

Summary Rabbits and guinea pigs immunized with folic acid coupled to methylated bovine serum albumin produced antibodies which bound the haptenic vitamin. The antibodies were of the high-affinity type with equilibrium constants in the range of 108 liters/mole and binding energies from -11 to -14 kcal/mole. The folate-binding capacity of the antiserum approximated 10-7 mole/liter, sufficient to bind all physiological folate with determinants for this antibody. Since the biological activity of antibody is a function of the product of the equilibrium constant and antibody concentration, these studies demonstrate the feasibility of inducing antibodies against folate which might interfere with the transport and metabolic function of this vitamin.