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In vitro effects of lidocaine on anaerobic respiratory pathogens and strains of Hemophilus influenzae.

Lidocaine is commonly employed as a topical anesthetic agent during fiberoptic bronchoscopic procedures or transbronchial brushing. Previous studies have demonstrated an inhibitory effect of lidocaine on the growth in culture media of gram-positive and gram-negative organisms, as well as several species of Mycobacterium and various fungi. The current in vitro investigation demonstrates an inhibitory, as well as a bactericidal, effect of lidocaine hydrochloride (in concentrations identical to those encountered during fiberoptic bronchoscopic procedures) on the common anaerobic respiratory pathogens and on multiple strains of Hemophilus influenzae. The finding helps to explaint the difficulty in producing proof via culture of the specific etiologic agent in inflammatory lesions from specimens obtained by fiberoptic bronchoscopic procedures or transbronchial brushing.