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Study of dyslipidemia and antioxidant status in chronic kidney disease patients at a hospital in South East Asia

Introduction: The prevalence of hyperlipidemia is a most common problem in developed and developing society. Abnormal increase level of total cholesterol, triglyceride (TG), very low-density lipoprotein (VLDL), and LDL caused cardiovascular disease (CVD) in chronic kidney disease (CKD). Dyslipidemia is a known marker for CVD in the common population. Significant abnormal total cholesterol, LDL, TG, VLDL, and high-density lipoprotein (HDL) are present in CKD patients. Materials and Methods: In this study, we tried to find out the levels of lipid profile and antioxidant levels in CKD patients and its correlation with CVD. This study included 159 human subjects of age group between 40 and 65 years, out of which 78 patients were CKD and rest 81 patients are matched healthy subjects (control group). Results and Discussion: Our study showed a significant increase in Blood Pressure compared to control subjects. Lipid profile (total cholesterol, VLDL, TG, and LDL) was found significantly deranged (P < 0.001) and there was a decrease in the levels of HDL-cholesterol compared to control subjects. Conclusion: Enzyme level (superoxide dismutase) was significantly decreased, and malondialdehyde level was significantly increased compared to control subjects which show the effect of dyslipidemia and oxidative stress associated with the chronic kidney disorder.