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Pathogenesis of Learning Disabilities in Epilepsy

The immature brain is more prone to seizures than is the mature brain because of an imbalance between the development of excitation and inhibition and a variety of other physiologic and structural features (1,2). Unfortunately, in addition to being common, seizures in young children often portend a poor prognosis for mental and motor development (3,4). There are some suggestions that seizures during early development are worse in regard to cognitive impairment than are those occurring in the mature brain (5). Although the poor prognosis after seizures during early life is often related to the underlying cause of the seizures, there is concern that the seizures themselves may be detrimental.