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A possible mechanism of action of estrogen at the cellular level in a model sebaceous gland.

The effect of estradiol administration and castration on testosterone (T) uptake and metabolism in vitro in two sebaceous gland analogues has been investigated. Uptake of T was decreased in the preputial glands of both cast rated and normal male rat and cast rated mice by estradiol estradiol administration. Conversion of T to dihydrotestosterone (DHT) was also decreased in the preputial glands of normal rats by estradiol administration. Castration alone caused increased uptake of T and decreased conversion of T to DHT when calculated as percent of total uptake compared to percentage conversion in glands of normal animals. The demonstration that estradiol suppresses T uptake and metabolism to DHT in normal male rats suggests a mechanism at the cellular level to explain how estradiol might inhibit sebum production.