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The significance of oral contraceptives in causing chromosome anomalies in spontaneous abortions.

The significance of oral contraceptives in causing chromosome aberrations in the fetus was studied in 246 non-selected spontaneous abortuses using Q-banding technique. No significant difference in the frequency of abnormal karyotypes or in the sex ratio was found between 124 abortuses of women who had taken oral contraceptives in comparison with 122 abortuses of women who had never used oral contraceptives. The study did, however, show that women who had used oral contraceptives were significantly younger than women who had not used these pills. In addition, the gestational age of the chromosomally abnormal abortuses was on the average 6 days longer in the group of women who had used oral contraceptives than in the group who had not. The difference was significant only with regard to the karyotype 45,X.