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Blood group A1 and A2 revisited: an immunochemical analysis

Background and Objective  The basis of blood group A1 and A2 phenotypes has been debated for many decades, and still the chemical basis is unresolved. The literature generally identifies the glycolipid chemical differences between blood group A1 and A2 phenotypes as being poor or no expression of A type 3 and A type 4 structures on A2 red cells, although this assertion is not unanimous.