{'fraction_non_alphanumeric': 0.031771674744211095, 'fraction_numerical': 0.010770059235325794, 'mean_word_length': 4.752321981424148, 'pattern_counts': {'":': 0, '<': 1, '<?xml version=': 0, '>': 1, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Tyrosine‐Kinase Inhibitors for Treatment in Hemodialysis Patients on Kidney Transplant Waiting List. Comment on: Nakai et al.

quate fluid removal has been linked with improved outcomes (2,3). In the current study, the SCUF group had significantly higher central venous pressure at the end of treatment compared to patients who received CVVH (18.7 vs. 14.8 mm Hg, P < 0.001) implying that lingering congestion could be the reason for the inferior survival observed in the former group. Second, there are no data in the article to indicate that the CVVH therapy led to substantial removal of pro-inflammatory cytokines, as they were not measured. Some of the provided results do indeed imply that the CVVH technique that was applied did not portend significant clearance properties: there was only a modest drop (i.e. 23%) in blood urea nitrogen (BUN) with CVVH therapy as compared to the target reduction in a conventional dialysis session (i.e. >65–70%). Of note, BUN and serum creatinine levels were similar to the SCUF group at the end of CVVH therapy. Finally, it is noteworthy that in other clinical settings with excessive inflammation (e.g. severe sepsis), removal of cytokines through CVVH is of no salutary effect and can portend even deleterious impact on the outcomes (4,5). There are a number of missing pertinent details in the article such as whether the exact clearance has been calculated in patients undergoing CVVH, whether preor post-filter replacement fluid was used, and whether the rate of replacement fluid has been adjusted. It is also unclear what the authors meant by “total number of dialysis” as both CVVH and SCUF are continuous modalities. In summary, we believe that the findings of this study lend support to previous reports on the association of efficient decongestion with improved outcomes in the setting of ADHF and CRS.