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1H NMR spectroscopy of glioblastoma stem‐like cells identifies alpha‐aminoadipate as a marker of tumor aggressiveness

Patients suffering from glioblastoma multiforme (GBM) face a poor prognosis with median survival of about 14 months. High recurrence rate and failure of conventional treatments are attributed to the presence of GBM cells with stem‐like properties (GSCs). Metabolite profiles of 42 GSC lines established from the tumor tissue of adult GBM patients were screened with 1H NMR spectroscopy and compared with human neural progenitor cells from human adult olfactory bulb (OB‐NPCs) and from the developing human brain (HNPCs).