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Warfarin in Sneddon's syndrome

To the Editor: Geschwind et al. [1] recently suggested, on the basis of their pathologic findings in one case of Sneddon's syndrome, that "warfarin anticoagulation may be the most appropriate intervention currently available.'' We focus on the possible occurrence of spontaneous intracranial hemorrhage, as exemplified by the following case.

A 25-year-old woman was admitted to our department in October 1992 for persistent headache and blurred vision. She had a history of livedo reticularis and intermittent acrocyanosis first noticed at age 14. She did not smoke and was not on oral contraceptives. …