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Tangential organization of thalamic projections to the neocortex in the mouse

Using the anterograde degeneration technique, we examine the tangential organization of a thalamofugal axon population (class I of Frost and Caviness, ′80) whose terminations are preferentially distributed to the middle tier (located in layers III and/or IV) of three radially separated tiers of thalamic projections to the neocortex. Less extensive data are also presented on the tangential organization of thalamofugal axon populations (class II of Frost and Caviness, ′80) that do not terminate preferentially in the middle tier, but that are otherwise heterogeneous with respect to their radial pattern of intracortical termination.