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Blood Oxygen Level Dependent Magnetic Resonance Imaging and Renal Tissue Oxygenation with Successive Inhibition of Renal Sodium Transport

Functional renal oxygen consumption, VrO2 is due to tubular reabsorption of sodium (TNa) in the proximal and distal nephrons, resulting in compartments (cortex/medulla) with distinct VrO2/TNa relationships. Compartmental divisions promote non‐invasive imaging strategies like MRI, to indirectly assess tissue oxygenation, (PtO2). However, the extent to which these regional PtO2 differences are affected by successive TNa are not fully understood. The objective is to determine VrO2 and intra‐renal regional alterations in PtO2 directly and indirectly during successive TNa inhibition. It is hypothesized successive TNa inhibition is accompanied by intra‐renal regional changes in PtO2. Pigs (n=6) underwent MRI scans at baseline, furosemide and acetazolamide. Five days later, the right kidney was instrumented with PtO2 sensors (cortex/medulla). PtO2 was measured during drug infusions (identical to MRI exam). There was a decrease in VrO2, and a 40% and 30% increase in medullary and cortical PtO2 following drug infusions. There was ~25% medullary and ~20–30% cortical decrease in BOLD signal with furosemide and acetazolamide administration, respectively. This study suggests successive inhibition of TNa is accompanied by intra‐renal regional PtO2 changes and these changes are detectable with BOLD‐MRI, a non‐invasive imaging modality.