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Increasing of Acromegaly Prevalence in Guayaquil, Ecuador: 2000-2019

Background: Reliable and up-to-date information on the epidemiology of acromegaly in Latin American countries remains to be lacking. Aims: This study aims to update the epidemiological data on acromegaly in Guayaquil city, Ecuador. Methods: Prospective and retrospective data of patients with acromegaly were collected from the five public health system hospitals in Guayaquil City, Ecuador, from January 2000 to December 2019. Age at diagnosis, baseline growth hormone levels, growth hormone after oral glucose overload, and serum insulin-like growth factor-1 concentrations were recorded. We determined the rate of prevalence of acromegaly using the 2010 population census information and the projected Ecuadorian population by calendar year and canton for the period from 2000 to 2019. Results: A total of 132 cases of acromegaly were reported, of which 77 are women (58 %) and 55 men (42 %) (Female-to-male ratio, 1.4:1). The overall mean age at diagnosis was 46 years (SD, 16 y). The mean age in women was determined to be 46.9 years (SD, 16.3 y), while for the men, it was 45.1 years (SD, 15.8 y). Our findings show that the prevalence of acromegaly is 49 cases per million inhabitants. Conclusions: The prevalence of acromegaly in Guayaquil, Ecuador are higher than what was previously reported and are closer to those described in the international literature.