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Pituicytoma of the Neurohypophysis: Analysis of Cell Proliferation Biomarkers

diminished libido and a six month history of poor concentration and headaches. No visual field changes were identified. Laboratory testing revealed normal blood hormone levels of total testosterone (10.16 nmol/L, normal 6.7-28.9), growth hormone (0.0 ng/ml, normal<5.0), insulin-like growth factor (132 ng/ml, normal 48-255), thyroid stimulating hormone (2.48 mUI/ml, normal 0.5-6.0), free thyroxin (0.98 ng/dl, normal 0.81.8), and cortisol (8.7 mcg/ml, normal 5-25). Blood prolactin levels were mildly elevated (131 ng/ml, normal 0-15), with decreased blood levels of luteinizing hormone (0.09 mUI/ml, normal 2-12), and follicle stimulating hormone (0.0 mUI/ml, normal 1-8). Magnetic resonance imaging (MRI) revealed a circumscribed suprasellar lesion measuring 25x25mm (Figure 1) displacing the pituitary stalk and compressing the optic chiasm and the floor of the third ventricle. There was no evidence of hydrocephalus. Based on MRI a diagnosis of pituicytoma was made. In order to get tissue for morphological studies and to resect subtotally the lesion a right fronto-temporal craniotomy was performed. At