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Trans‐sialidase inhibition assay for the detection of Trypanosoma cruzi infection in blood donor samples from Argentina

Background and Objectives  Conventional serology tests for Trypanosoma cruzi blood banks screening are neither sensitive nor specific enough, and currently no gold standard assay is available. Trans‐sialidase inhibition assay (TIA) detects neutralizing antibodies against T. cruzi trans‐sialidase. Conventional serology inconclusive, positive and negative blood donor samples were evaluated by employing TIA as a supplementary test.