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Development and progression of overactive bladder urinary in heart failure rat

Heart failure (HF) and urinary symptoms (US) is highly prevalence and affects approximately 37% of man and 67% of woman have a significant impact on quality of life. There is evidence that HF and US share risk factors that are associated with autonomic nervous system dysfunction, which has also been implicated in overactive bladder (OAB). Thus, the aim of study was evaluated the possible relationship in the progression OAB associate to HF in rats submitted to arteriovenous fistula (HF model). After 4 or 12 weeks, cystometric parameters (ex vivo) were assessed: Threshold pressure (the intravesical pressure immediately before micturition); Post‐void pressure (the intravesical pressure immediately after micturition); Contraction micturition (the peak pressure reached during micturition); Capacity (the volume of saline needed to induce the first micturition); Frequency of non‐voiding contractions. The histomorphometry (in vitro), also were performed. After 4 weeks, HF animals have an increase of micturition contraction and threshold pressure associated with a decrease of capacity (P<0.05) when compared to group sham. Moreover, after 12 weeks, HF animals increase of micturition contraction, threshold pressure and frequency of non‐voiding contractions and keep the decreased of bladder capacity (P<0.05) when compared to Sham group. In addition, HF group (12 weeks) increase the frequency of non‐voiding contractions (P<0.05) when compare to HF group (4 weeks). Histomorphometry showed that HF group (4 weeks) present an increase of urothelium thickness (P<0.05) compared to sham group, whereas, HF group (12 weeks) present an increase in the detrusor muscle (P<0.05) when compared to sham group. Thus, HF rats, using the arteriovenous fistula, promote structural changes in the detrusor muscle contributing to the development of OAB and impaired of urinary function. Furthermore, our data suggest that OAB is progressive and is associated with the HF time course.