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Low plasma antioxidant activity is associated with high lesion volume and neurological impairment in stroke.

To the Editor: 

We read with great interest the article by Leinonen et al1 in the January 2000 issue of Stroke. In this study, low total peroxyl radical-trapping potential (TRAP) of plasma, but not of cerebrospinal fluid, was found to be associated with high lesion volume and high neurological impairment. An inverse correlation between plasma TRAP and infarct volume ( r =−0.53, P =0.01 for TRAP and r=−0.56, P =0.007 for TRAPunid), in addition to higher lesion volume in patients with a lower-than-mean level of plasma TRAP (1190 μmol/L) than patients with a TRAP level higher than that (15.3±14.1 versus 5.6±7.1, P =0.03), was the affirmative underlying statistical findings for this result. The infarct volume–plasma …