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Effects of in vivo administration of anti-Ia antibodies on contact sensitivity.

Our previous studies of the effects of the in vivo administration of anti-la (anti-class II major histocompatibility antigens) antibodies in mice demonstrated that, although the antibodies bind to epidermal Langerhans' cells, they do not affect their antigen-presenting capacity in vitro. In this study we investigated the effects of the in vivo administration of these antibodies on the induction and expression of contact sensitivity. We found that the antibodies inhibit the induction of contact sensitivity significantly and affect the elicitation phase to a much lesser extent. The inhibition is short-lived and probably not attributable to the induction of suppressor cells.