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A family with collagenous colitis, ulcerative colitis, and Crohn's disease

Ever since Lindstrom first described his case of collagenous colitis (1), clinical investigators have wondered about its relationship to the classical forms of inflammatory bowel disease (IBD), ulcerative colitis (UC), and Crohn’s disease (CD). Collagenous colitis (CC) has been reported in association with CD in 5 patients. We report the present family because it is unique and may shed a little light on this problem. We discovered this constellation of patients in our files in searching for parent-child pairs of IBD. We found a non-Jewish family with a mother with CC occurring later in life than the IBD of her children, a daughter with UC, and a son with CD (the sixth case).