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[Biochemical changes in the glandular part of the rat stomach as affected by N-methyl-N'-nitro-N-nitrosoguanidine].

Biochemical changes in the stomach mucous membrane of rats treated with N-methyl-N-nitro-N-nitrosoguanidine (MNNG) were studied. Carcinogenesis was shown to involve considerable changes in gastric mucous membrane, e. g. disorders in biosynthesis of isoforms of pepsinogen-pepsin. Their level and proteolytic activity are gradually declined. This effect can be reversed at an early stage of treatment and is persistent in advanced tumors of glandular part of rat stomach.