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NEUROLOGICAL FINDINGS IN TWINS DISCORDANT FOR FEBRILE CONVULSIONS

The present study was designed to investigate whether clinical neurological testing would reveal poorer performances in twins with a history of febrile convulsions (FC) than in their healthy co‐twins. 46 pairs of monozygotic and dizygotic twins, discordant for FC, were subjected to neurological examination by a battery of tests particularly suited for demonstrating minor changes in function. In 3 of the tests (for exophoria, stereopsis, and homolateral associated finger movements) the twins with a history of FC showed significantly poorer performances than their healthy co‐twins, and in other functions studied the results were in general poorer in the twins with FC. Separate assessment of the 14 monozygotic, disordant pairs revealed the same tendency to dysfunction in the twins with FC, and in 2 tests (homolateral associated finger movements, imitation of contralateral handposition) the differences were significant. The causes of the correlation which was found between FC and neurological dysfunction have not been elucidated on the basis of the present findings, but according to the literature it seems most likely that the dysfunction is conditioned by cerebral damage caused by the FC. That birth injury might be responsible for the neurological deficits cannot be ruled out but seems less likely.