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CHOROID PLEXITIS PRODUCED IN RATS BY CYCLOPHOSPHAMIDE

High doses of the alkylating drug, cyclophosphamide, injured the choroid plexuses of the rat. The lesion was characterized by severe edema, hemorrhage, and slight, focal leukocytic infiltration. This progressed to necrosis of individual villi and occasionally to hemorrhagic infarction of an entire plexus. The plexus of the fourth ventricle was more susceptible than the others and a similar lesion occurred in the ciliary processes of the eye. This drug-induced plexitis may prove useful for investigation of function and topographic specialization among the several choroid plexuses.