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When the mind comes to live inside the body: The ontogeny of the perceptual control clock.

In this Editorial we discuss the neurobiological processes underlying early emergence of awareness that we term the "when" and "how" the mind comes to live inside the body. We describe an accumulative developmental process starting during embryonic life and continuing to fetal and postnatal development, of coupling of heart rate, body movements and sleep states on the behavioral level with underlying mechanisms on the structural, functional, cellular and molecular levels. A developmental perspective is proposed based on Perceptual Control Theory (PCT). This includes a developing sequence of modules starting from early sensing of neural intensities to early manifestation of human mindful capacities. We also address pharmacological treatments administered to preterm infants, which may interfere with this development and highlight the need to consider this potential "side effect" of current pharmaceuticals when developing novel pharmacogenomic treatments.