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Synergistic action of metolazone with "loop" diuretics.

Features of the brachydactyly in this family were similar to those described by Vidal,4 and the variation in severity among family members has been reported.5 The association of the condition with colorectal cancer may have been due to chance or may be a true syndrome, permitting identification of patients at risk for colorectal neoplasia. We should be interested to hear from others who may have observed the association. In view of the high incidence of colorectal cancer in this family we propose to keep the family under periodic surveillance.