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SPECTRUM OF PATHOLOGIES IN PATIENTS WITH ENLARGED PROSTATE

Objective: To ascertain the frequency of various pathological disorders related to prostate so that benign lesions of prostate can be distinguished from adenocarcinoma prostate to avoid wrong diagnosis. Material and Methods: This study (descriptive cross sectional) was carried out in the Histopathology Department, Foundation University Medical College, DHA Islamabad from 1st August 2019 to 31st July 2020. A total 200 biopsy specimens from patients between 50 to 92 years of age were fixed in 10 % formalin. The samples were grossed and routinely processed under standard conditions for paraffin embedding. Haematoxylin and Eosin stains were used to stain the slides while special stains were used as per requirement. Microscopic evaluation was done by consultant histopathologists after correlating histopathological findings with clinical data. Results: Total 200 individuals were incorporated in this study. Age of patients ranged from 50 to 92 years. The mean age of study subjects was found to be 67 +9.64 years. Majority (37%) of individuals in the study belonged to age group of 61-70 years. Out of total 200 patients, 179 patients (89.5%) had diagnosis of Benign Prostatic Hyperplasia (BPH). Twenty patients (10%) were diagnosed with Adenocarcinoma prostate. One out of 200 patients (0.5%) was diagnosed as a case of Prostatitis with no other finding. Conclusion: Benign prostatic hyperplasia is most frequent pathology of patients with prostate enlargement. Prostate cancer needs to be distinguished from spectrum of benign lesions to avoid wrong diagnosis. Key Words: Adenocarcinoma prostate, Benign prostatic hyperplasia (BPH), Prostatitis.