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Relationship between expression of heat shock proteins in endometrium and unexplained infertility

Objective: To study the relationship between the expression of heat shock proteins (HSP) and unexplained infertility. Methods: Expression of HSP70 and HSP90α in endometrium of 72 cases of unexplained infertility and 34 cases of control group was investigated with S P method. Antibodies to spermatozoa in 53 cases of unexplained infertility were determined by ELISA. Results: Rates of the expression of HSP70 in the endometrium of unexplained inferlity and control group were 65% and 38%, respectively ( P0.05 ). Rates of the expression of HSP70 in the positive and negative of antibodies to spermatozoa were 81% and 30%, respectively ( P0.01 ). Rates of the expression of HSP90 in the endometrium of unexplained infertility and control group were 54% and 47%, respectively ( P 0.05 ). Rates of the expression of HSP90 in the positive and negative of antibodies to spermatozoa were 69% and 24%, respectively ( P0.01 ) Conclusion: The over expression of HSP70 and HSP90 α in the endometrium of unexplained infertility represents a stress reaction of autoimmunity. As HSPs gene is inhibited by using inhibiting materials. It may probably be a new therapy for the unexplained infertility.