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Determination of Folic acid in Complex Vitamin Capsules by HPLC

Objective:To develop a HPLC method for the determination of folic acid in complex vitamin capsules.Methods:The determination was performed on a KR100-5 C18 column(4.6×250 mm,5μm)with the mobile phase consisting of methanol-2% acetic acid aqueous solution(containing 0.1% 1-octanesulfonate,sodium salt and 0.2% ethylenediamine)(25:75,v/v) with a flow rate of 0.5mL.min-1,the determination was made by a U.V.detector at 285nm wavelength.Results: The method offered good linearity from 0.5~50μg.mL-1,relativity coefficient was 0.9997,the detection limit was 7.3 ng,the average recovery was 96.2%.the precision of method was from 2.8%~3.0%(n=6).Conclusions: The developed HPLC method was accurate and precision,and could be used for the determination of Folic acid in Complex Vitamin Capsules.