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SNAP-25 gene variations and attention-deficit hyperactivity disorder in Iranian population

Objectives: Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition of childhood characterized by persistent symptoms of hyperactivity, inattention, and impulsivity. The objective of this study was to investigate the association of synaptosomal-associated protein of 25 kDa (SNAP-25) gene variants with ADHD. Methods: A case-control study with a total of 150 children with ADHD (mean age 9.61; range 6–16; gender ratio 105m/45f) and 150 normal children (mean age 10.02; range 6–16; gender ratio 98m/52f) was conducted. Genomic DNA was extracted from peripheral blood of all samples and SNPs rs78428954 and rs3746544 located in SNAP-25 gene were genotyped. Results: Our analysis indicated that there is no significant association between none of studied variants in SNAP-25 and ADHD. Discussion: To our knowledge, it is the first report of SNAP-25 genotyping in Iranian patients with ADHD. Further investigations with larger populations are needed in order to clarify the exact role of SNAP-25 variations in susceptibility to ADHD.