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Investigate Cigarette Smoke Induced IL‐8 Secretion in Ovarian Cancer Cells and Estrogen Mediated Modulations

Cigarette smoking is a global health crisis and exposure to cigarette smoke (CS) leads to variety of diseases including many cancers. Although there are few clinical reports involving CS exposure with the ovarian cancer, laboratory based reports are rare. The focus of our laboratory is to investigate whether CS contributes to the development of ovarian cancer and unveil the role of estrogen in CS induced effects. Our preliminary data shows that CS induced functional changes in ovarian cancer cells (OCCs). The objective of current work is to investigate IL‐8 release as one of the contributing mechanism for CS induced effects. The specific aims are 1). Detection of CS induced IL‐8 release 2). Investigate whether estrogen cause IL‐8 release 3) Examine estrogen's role in modulating CS induced IL‐8 release.