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My O'Myeloid, a tale of two lineages

Blood giving rise to endothelium, evidence of which is described by Bailey et al. (1) in this issue of PNAS, has been a hot-button topic in the adult hematopoietic/vascular literature. Paradigms of hematopoietic and endothelial shared origins are well established in the embryo. However, the demonstration that this phenomenon occurs in the adult has been significantly more controversial.