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Ineffectiveness of a purine analogue, EMD 28422, in two animal tests of anxiolytic action

EMD 28422 was compared to chlordiazepoxide for antianxiety activity in two behavioral tests known to predict the anxiolytic action of drugs. In the conflict test, male rats were trained to respond for food reinforcement in which some of the reinforced responses also resulted in the delivery of footshock. Treatment of these rats with chlordiazepoxide but not with EMD 28422 antagonized the foot‐shock‐induced suppression of responding. In the drug discrimination test, male hooded rats were trained to discriminate the anxiogenic action of pentylenetetrazol from saline by responding for food reinforcement on one of two levers after pentylenetetrazol treatment (subconvulsant dose) and on the other lever after saline injection. Pretreatment with chlordiazepoxide and not with EMD 28422 antagonized the pentylenetetrazol stimulus. Ineffectiveness of EMD 28422 in both tests sensitive to chlordiazepoxide action suggests lack of anxiolytic efficacy of this drug, despite its reported enhancement of benzodiazepine binding in the brain.