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Suppression of long non‐coding RNA LET potentiates bone marrow‐derived mesenchymal stem cells (BMSCs) proliferation by up‐regulating TGF‐β1

Long non coding RNAs (lncRNAs) show an encouraging trend in regulating the proliferation of bone marrow‐derived mesenchymal stromal cells (BMSCs). The present study investigated the role of lncRNA low expression in tumor (LET) in BMSCs proliferation. Our result showed that LET was down‐regulated in rapidly proliferated BMSCs (P < 0.05). Suppression of LET promoted BMSCs proliferation and over‐expression of LET inhibited BMSCs proliferation (P < 0.05). LET negatively regulated the expression of transforming growth factor β1 (TGF‐β1) in BMSCs (P < 0.05). Knockdown of TGF‐β1 reversed the LET suppression‐induced BMSCs proliferation (P < 0.05). Moreover, knockdown of TGF‐β1 alleviated the LET suppression‐induced activation of Wnt/β‐catenin pathway in BMSCs. Therefore, we drew the conclusion that LET suppression promoted BMSCs proliferation by up‐regulating the expression of TGF‐β1 and activating Wnt/β‐catenin pathway.