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Critique of a Computer Model Study of AC Defibrillation

The study reported by Meunier et al.1 in this issue of the Journal used an advanced model of a slice of the heart to study possible roles of entrainment of the heart in de brillation with alternating current (AC). Results of this study show entrainment during AC stimulation. In addition, a decrease in the de brillation threshold (DFT) and a rise in virtual electrode polarization (VEP) occurred as the frequency of AC was increased. Single-period stimuli produced higher DFTs and weaker VEPs compared with longer-duration AC. Authors report that entrainment contributes to stronger VEP and thus lower DFT at high frequencies.