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Low‐ Versus High‐Dose Rituximab for Rheumatoid Arthritis: A Systematic Review and Meta‐Analysis

The approved dose of rituximab (RTX) for rheumatoid arthritis (RA) is 2 × 1,000 mg infusions given 2 weeks apart. There is contradictory evidence regarding the effectiveness of a lower‐dose regimen (2 × 500 mg) of RTX. Our aim was to compare the efficacy and safety of low‐ and high‐dose RTX and to test the noninferiority of the low‐dose regimen.