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Drug absorption in the gut.

Drugs are most commonly administered to patients as solid dosage forms given orally. Although this statement is less true in anaesthesia than in many other fields of medicine, a substantial amount of drug therapy prescribed by anaesthetists is given by mouth. It is often assumed that once a drug has been given by mouth it will be well absorbed and achieve its desired therapeutic effects. However, such a drug has to pass many barriers before it reaches the systemic circulation. The problems of poor biovailability of drugs are now well known, particularly in respect of digoxin (Johnson et al., 1973). We are now more aware of the properties a drug must possess in order to be absorbed and this article concentrates on these and other factors that influence the absorption.