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Direct determination of cadmium, nickel, and zinc in rat lungs: by atomic absorption spectrophotometry.

An atomic absorption method for the direct determination of metals in mammalian tissues has been developed. The procedure, which involves digestion of the sample with a quaternary ammonium hydroxide, allows one to measure metals normally present in low concentrations, such as cadmium and nickel, with a great degree of sensitivity and a minimal amount of sample handling.