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Safety and effectiveness of endoscopic mucosal resection combined with chemotherapy for early gastric cancer.

OBJECTIVE
To study the safety and efficacy of endoscopic mucosal resection (EMR) combined with chemotherapy in patients with early gastric cancer.


PATIENTS AND METHODS
Continuously, 112 patients of early gastric cancer (IA-IB) were chosen to receive the treatment of EMR. The 112 patients were divided into two groups, the control group and the observation group. The control group consisted of 56 patients who were treated with only EMR while the observation group consisted of 56 patients who were treated with both EMR and adjuvant chemotherapy (5-FU+oxaliplatin). A one-year's follow-up visit on the 112 patients was made.


RESULTS
The two groups' curative resection rate and occurrence of complication are inconsistent but the difference ratio (p > 0.05) is of no statistical significance. However, observation group's recurrence rate declined observable and the two groups' difference ratio (p < 0.05) is of statistical significance. What's more, the observation group's health index, emotional sound index and mental health index are higher than those of the control group and the difference ratio (p < 0.05) is of statistical significance.


CONCLUSIONS
The method of combining EMR and chemotherapy can reduce recurrence rate and improve living standard while it generates no adverse reactions and keeps the immunity of organism sound at the same time.