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[Association between folic acid supplement in peri-conceptional period and depression in pregnancy: a cohort study].

OBJECTIVE
To describe the epidemiological characteristics on the supplement of folic acid in progestation and early pregnancy, and to probe the protective effects of supplement of folic acid in early pregnancy against pregnant depression, in Ma'anshan city, Anhui province.


METHODS
In this cohort study, 5 150 subjects who had their first antenatal examination at Ma'anshan Maternal and Child Care Centers were recruited under informed consent, from October 2008 to October 2010. All the information were collected through questionnaires in the first, second and third trimesters respectively. A "Center for Epidemiological Studies Depression Scale (CES-D)" was used to assess the mood of depression in the second questionnaire. Single factor analysis and the unconditional multivariate logistic regression were applied to analyze the association of supplement folic acid in peri-conceptional period and pregnancy depression.


RESULTS
In the study, the prevalence of those who had never taken the supplement folic acid but only the supplement folic acid in progestation and supplement in the first-trimester, or supplement in the peri-conceptional period were 27.3%,0.5%, 27.4% and 17.9%, respectively. The incidence of pregnancy depression was 4.8% (247/5 150). Data from logistic regression analysis showed that, supplement of folic acid only in the first-trimester or in the peri-conceptional period were negatively associated with pregnancy depression even after adjustment for potential confounders. The adjusted odds ratio were 0.63 (95%CI:0.44-0.90) and 0.61 (95%CI:0.39-0.95) respectively.


CONCLUSION
Supplement of folic acid in peri-conceptional period could be a preventive factor for pregnancy depression.