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Partition and distribution coefficients of aryloxypropanolamine β‐adrenoceptor antagonists

Abstract— n‐Octanol/water partition and distribution coefficients of fifteen β‐blockers have been measured and the relationships between log P (neutral species), log Pi (fully ionized species) and log D7·4 have been examined. A strict correlation exists among these three parameters, suggesting that the ionization exerts similar effects on the partition behaviour of these drugs.