{'fraction_non_alphanumeric': 0.024031007751937984, 'fraction_numerical': 0.002325581395348837, 'mean_word_length': 4.894977168949771, 'pattern_counts': {'":': 0, '<': 1, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
The effect of barbiturate on retinal functions. I. Effects on the conventional electroretinogram of the sheep eye.

The present work is the first in a series of investigations on the effect of barbiturate on retinal functions. The changes in the conventional ERG of the dark-adapted, intact sheep eye were studied after i.v, administration of an ultra-short acting barbiturate, thiopental. After injection of small and moderate doses (< 20 mg/kg), the a- and b-wave amplitudes were found to increase. Larger doses resulted in a further enhancement of the a-wave amplitude, whereas that of the 6-wave diminished. Transient falls in the arterial blood pressure were also recorded after barbiturate administration. Since effects on mammalian ERG of alterations in retinal blood circulation have been the subject for discussion, the ERG was studied after lowering the blood pressure by electrical stimulation of the free-dissected left vagal nerve. The reduction in blood pressure obtained in this way was recorded without concomitant changes in the ERG. For this reason we exclude the possibility of a barbiturate mediated reduction in blood pressure as the mechanism behind the changes in retinal function of the intact sheep eye after administration of, at least, small doses of barbiturate.