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Restoration of Fluid and Electrolyte Homeostasis after Proximal Jejunostomy: Role of Oral Glucose Polymer Electrolyte Therapy and Water Exclusion

Measurements of plasma and urinary radioactivity over 10 days showed that the FCR of lzJl-labelled LDL was 0.134 and of 1311-labelled LDL-CHD was 0.115. Thus the receptor-mediated fractional rate of LDL catabolism, calculated as total FCR (lz'I) minus non-specific FCR (I3'I) was 0-019 in the homozygote, compared with 0.032 and 0.110 respectively in the four heterozygotes and four control subjects studied by Shepherd et al. (1979). In vitro, the mean binding plus internalization and degradation of the 13'I-labelled LDGCHD by normal fibroblasts was only 5.7% of that of the 12'lI-labelled LDL at concentrations of 1-10 p g of LDL protein/ml; the stability of the IJ1Ilabelled LDGCHD in vluo was demonstrated by its relative resistance to precipitation from plasma by heparin402 mol/l manganous chloride (69%) compared with lz'II-labelled LDL (88%). Taken overall these results provide confirmatory evidence of a defect in vivo of receptor-mediated LDL catabolism in FH.