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AB0764 Gender Differences in Axial Spondyloarthritis

Background Gender differences in demographic and clinical features of ankylosing spondylitis (AS) has consistently been demonstrated in several cohorts but there is little knowledge of those of axial spondyloarthritis (axSpA) as a whole group and of nonradiographic axial spondyloarthritis (nr-axSpA). Objectives The aim of this study was to assess the gender differences in axSpA. Methods Demographic and clinical data in our local axSpA database were evaluated and compared between male and female patients. Subgroup analyses in patients with AS/radiographic axSpA (r-axSpA) and nr-axSpA were also performed. Results There were 438 patients with axSpA [279 male (64%)], who fulfilled the ASAS classification criteria (Table 1). 349 out of them were classified as having AS/r-axSpA [236 male (68%)] and 89 as having nr-axSpA [43 male (48%)]. In female patients with axSpA, age of disease onset and age of diagnosis was older and delay of the diagnosis was longer compared with male patients (p<0.05). Peripheral arthritis and dactilitis were seen more in females (p<0.05) but entesitis was more frequent in males. At the time of diagnosis, BASDAI was higher in females (p<0.05); but BASMI scores (p<0.05) and CRP (p<0.05) were higher in males. Although neck pain was more common in female axSpA patients; cervical rotation disability and BASMI score assessments were worse in males (Table 1). When subgroup analysis was performed, females with nr-axSpA were found as having worse BASDAI (p<0.05) and BASFI scores (p<0.05) and males with AS as having higher CRP levels (p<0.05) and worse BASMI scores (p<0.05). Conclusions This study demonstrated that AS/r-axSpA was more prevalent among men but the prevalence of males and females in patients with nr-axSpA was similar. While subjective disease activity parameters were higher among women with axSpA as well as in those with nr-axSpA, men with axSpA experienced higher objective disease activity parameters and more restricted spinal mobility as well as in those with AS/r-axSpA. However, objective disease activity and spinal mobility scores were similar between women and men with nr-axSpA. Disclosure of Interest None declared