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PDGFRβ Induces Ribosome Biogenesis in Aortic Smooth Muscle Cells

Arterial fibrosis (AF) is an important determinant of cardiovascular health. AF results in a thickened arterial wall and loss of compliance which is a direct result of excessive extracellular matrix (ECM) accumulation. Platelet Derived Growth Factor Receptor β (PDGFRβ) activation in vascular smooth muscle cells (VSMCs) results in AF that manifests with increased VSMC proliferation and increased collagen synthesis and deposition in the arteries. However, the mechanisms by which PDGFRβ activation results in AF are not fully elucidated.