{'fraction_non_alphanumeric': 0.054520037278657965, 'fraction_numerical': 0.032618825722273995, 'mean_word_length': 5.116809116809117, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Medication treatment of directly observed therapy and self administration in tuberculosis patients: systematic literature review

Purpose:Tuberculosis (TB) is one of the most significant infectious diseases. Despite global inoculation and beating trials, the incidence of tuberculosis is still not decreasing. The World Health Organization (WHO) recommends the Directly Observed Therapy (DOT) tuberculosis control strategy, which has been reported to be successful in many countries. However, controversy remains whether DOT benefits have been proven. Objectives:This study is to compare its effectiveness between different types of treatment TB medication modalities: Health care provider DOT (HCP DOT) versus Self Administration (SAT). Methods:We searched studies of cohort studies that used the HCP DOT with TB patients. The review was conducted using electronic database of PubMed, CINAHL, EMBASE, Cochrane, Korea Med, KISS, RISS, NSDL, and NANET. Of 223 studies identified, 80 studies were excluded because of duplication. Of 38 studies screened, 4 studies met the inclusion criteria and all studies were analyzed by meta-analysis. To appraise quality of the evidence, we used Scottish Intercollegiate Guidelines. Result:There are 5 types of medication treatment as cure, completion, treatment success (cure or completion), default, and failure. No statistically significant difference was detected between HCP DOT and SAT in cure (95% CI: 0.80∼10.01, p = 0.10, 3 trials), with similar results for completion (95% CI: 0.41∼1.55, p = 0.50, 3 trials). Treatment success (cure or completion) was not associated with HCP DOT compared with SAT (95% CI: 0.53∼6.90, p = 0.32, 4 trials). There was no significant difference detected in default (95% CI: 0.12∼2.06, p = 0.34, 4 trials) and failure (95% CI: 0.27∼1.92, p = 0.51, 3 trials) between HCP DOT versus SAT. Conclusion:Based on available evidence, HCP DOT can’t improve medication treatment compared with SAT. Although this study utilized cohort studies, RCT studies have to be carried out for the best evidence. Based on the results of this study, WHO should reconsider implementation of DOT.