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Expression of cytochrome P450 enzymes in hepatic organoid reconstructed by rat small hepatocytes

Background and Aims:  Small hepatocytes (SH), which are hepatic progenitor cells, were isolated from an adult rat liver. SH in a colony sometimes change their shape from small to large and from flat to rising/piled‐up. The morphological changes of SH may be correlated with hepatic maturation. Cytochrome P450s (CYP) are drug‐metabolizing enzymes and the expression is one of hepatic differentiated functions. However, it is well known that the re‐expression and maintenance of CYP activity are very difficult in cultured hepatocytes. We investigated the expression of CYP and the enzymatic activities in long‐term cultured SH.