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Histopathologic observations on galactose-induced cataract in rats.

The sequence of ophthalmologic and pathologic events provoked in the lens of rats fed a massive dose of galactose (50% in commercial diet) was followed for a period of up to 162 days. The progress of the lenticular opacity was closely correlated with the degeneration and destruction of the lens fibers. During the course of cataract development, proliferation of the lens fibers from the superficial nuclear zone was observed concurrently with degeneration and destruction of the lens fibers in the surrounding lenticular tissue.