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DES-ASP1-Angiotensin II: Possible Role in Mediating Responses of the Renin-Angiotensin System

Summary In dexamethasone-treated dogs, both antiogensin II and its heptapeptide fragment (des-asp1-angiotensin II) stimulated the secretion of the adrenal steroids aldosterone, corticosterone, and cortisol. Further, there was no statistically significant difference in the steroidogenic potency of the two peptides. An interesting incidental finding was the decrease in PRA with both peptides, again with no demonstrable difference in the magnitude of the responses. The present data are consistent with the hypothesis that the heptapeptide mediates responses produced by the renin-angiotensin system in both the adrenals and the kidneys. We thank Lois Hoover, Sandy Anderson, Dale Welch, and John Thomas for their technical assistance.