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Synthesis, Characterization and Antitumor Activities of Cis-Chlorogenic Acid[(1R,2R)-1,2-Cyclohexanediamine] Platinum(II)

Abstract. In order to obtain a chlorogenic acid platinum complex, The intermediate Pt(C6H14N2)(H2O)2(NO3)2 solution was synthesized from Pt(C6H14N2)I2 and AgNO3, and it was treated with the anion exchange resin to give the key intermediate Pt(C6H14N2)(OH)2. The key intermediate was subsequently reacted with chlorogenic acid in butyl alcohol. The complex structure and component were characterized by elemental analysis, ESI-MS, 1H-NMR and IR and the anticancer activity was measured by MTT method. The result showed that its structure was consistent with the title compound and had inhibiting effect on the growth of tumor cell lines in vitro.