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Immunogenic properties of domestic anthrax vaccines

Specific prevention of anthrax is an important link in ensuring the episodic and epidemiological well-being of the country. The registered anthrax vaccines are successfully used today, along with their advantages, are not without drawbacks. Efforts to develop a new generation of vaccines are aimed at increasing immunogenicity while maintaining safety. The most popular ways of implementation are combining the advantages of vaccines in a complex preparation. The article presents research on the comparative study of the immunogenic properties of live anthrax vaccines from STI-1, 55 VNIIVViM strains, and combined vaccine "Antravak". The advantage of the Antravac vaccine, formed on a combination of live spores and a sorbed protective antigen, providing a significant increase in immunogenicity, is shown. Vaccination with the "Antravak" on day 7 caused the formation of guinea pigs in 277–957 times more intense immunity than analogues.The results of studies of the humoral response registered antibodies to the protective antigen only in the blood sera of guinea pigs immunized with the Antravak vaccine.