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Marked GH secretion after ghrelin alone or combined with GH‐releasing hormone (GHRH) in obese patients

objectives  Ghrelin is a 28‐amino‐acid peptide, predominantly produced by the stomach. It displays a strong GH‐releasing activity mediated by the hypothalamus–pituitary GH secretagogue (GHS)‐receptor (GHS‐R). There are different studies that suggest the importance of ghrelin in feeding and weight homeostasis. In obesity there is a markedly decreased GH secretion. For both children and adults, the greater the body mass index (BMI), the lower the GH response to provocative stimuli, including the response to GHRH. However, the response to the natural GH secretaogogue ghrelin is unclear at the present time. The aim of the present study was to evaluate the GH response to ghrelin alone or combined with GHRH in a group of obese patients, in order to further understand the deranged GH secretory mechanisms in obesity and to clarify the mechanism of action of ghrelin.