{'fraction_non_alphanumeric': 0.020309477756286266, 'fraction_numerical': 0.009671179883945842, 'mean_word_length': 5.088235294117647, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
63 MODULATION OF THE SECRETORY RESPONSE TO CHOLERA TOXIN BY DIETARY FAT

The effects of dietary fat on jejunal water, solute and glucose absorption, and on cholera toxin-induced secretion were studied in 4 groups of rats, using an in vivo steady state perfusion technique.Weanling rats were fed isocaloric diets with 40% of their total calories as fat, (varied in the degree of saturation and w6/w3 ratio) for 7-9 weeks. The absorption of water, electrolytes and glucose in steady state perfusion was altered dramatically, with highest rates of water and electrolyte absorption in the high polyunsaturated group.Feeding either high polyunsaturated or high monounsaturated diets decreased the water and electrolyte secretion in response to cholera toxin compared to control chow diet (4% fat) or feeding high saturated fat diet.We conclude that variation in the fatty acid profile of the diet alters the transport properties of the fat jejunum. This may explain the beneficial effects of added dietary fat in some diarrhoeal disorders.