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The combination of the Zenon labeling technique and microscopic image analysis to study cell populations in normal and psoriatic epidermis

Background:  In order to better characterize epidermal cell populations in psoriatic vs. normal skin, fluorescent immunohistochemical techniques were extended with a new labeling technique. The Zenon technique conjugates primary antibodies rapidly and quantitatively after which they are used in the same manner as covalently labeled primary antibodies. Digital microscopic images of epidermal expression of keratin 10 and keratin 6 (differentiation), Ki‐67 antigen (proliferation), and keratin 15 and β‐1 integrin (basal layer) were analyzed in a standardized way. Co‐expression of different proteins was demonstrated.