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Serum antibodies to Klebsiella capsular polysaccharides in ankylosing spondylitis.

OBJECTIVE
To measure antibodies to Klebsiella capsular polysaccharides in the sera of HLA-B27 positive patients with ankylosing spondylitis (AS), compared with HLA-B27 positive and HLA-B27 negative healthy control subjects.


METHODS
Antibodies were detected by means of an enzyme-linked immunosorbent assay specific for each of the 77 known Klebsiella serotypes.


RESULTS
Significantly elevated frequencies and titers of antibodies to capsular polysaccharides K26, K36, and K50 were detected in sera from AS patients, compared with controls.


CONCLUSION
These results suggest the predominance of Klebsiella serotypes K26, K36, and K50 in patients with AS.