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[Santiago Ramón y Cajal and cardiology: His little known discovery of sarcolemma in the cardiomyocytes].

The first description of sarcolemma in cardiomyocytes was reported by Ramón y Cajal in Textura de la fibra muscular del corazón, published in 1888. In this article, he summarized his observations of the structure of cardiac fibres applying gold chloride dyes and posterior corrosion by acids. The sarcolemma, the fundamental membrane of the cardiac muscle cell, which was not recognized at that time by other researchers, was demonstrated by Ramón y Cajal who provided the first evidence supporting its existence and hypothetized about its functional significance.