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A Bioactive Peptide Ameliorates Diet‐induced Nonalcoholic Fatty Liver in Senescence Accelerated Mice Prone 8 (SAMP8)‐Genetic Ageing Model

Aging and high‐fat diet (HFD) hypernutrition represent two major risk factors for nonalcoholic fatty liver disease (NAFLD). To investigate the chemopreventive effects of bioactive compounds in fatty liver, our lab has successfully developed various dietary murine models for the past years. Considering special issues with drug administration in elderly subjects, we purposed in this present work to induce NAFLD in senescence‐accelerated mice prone 8 (SAMP8) specific strains with HFD (60% calories from fat) and evaluate a novel bioactive peptide (DIKTNKPVIF) synthesized from a well‐studied lipolysis‐activating potato protein hydrolysate (PH), for its efficacy to reduce HFD‐driven fat deposition and associated proinflammatory events responsible for NAFLD development in SAMP8 aging mice.