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Long-term proton pump inhibitors use and risk of gastric cancer: a meta-analysis of 926 386 participants

We read with interest the study by Cheung et al 1 reporting that long-term use of proton pump inhibitors (PPIs) was associated with an increased risk of gastric cancer (GC) in participants after Helicobacter pylori eradication. Considering PPIs were widely used for the treatment of acid-related disorders, and previous studies about PPIs use and risk of GC did not have a consistent result. To better understand this issue, we conducted this meta-analysis that investigated the associations between long-term PPIs use and risk of GC.

We searched the PubMed, Embase and Web of Science for potential studies published before March 2018. …