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Rabbit Achilles Tendon Reconstruction with a Tissue-Engineered Silk Scaffold

MethodS: The silk scaffold was constructed using a weaving machine and dry-coated with collagen-hyaluronan (HA), whereas the composite silk scaffold was made by covering a silk scaffold with a lyophilized collagen-HA substrate. We implanted the tendon prostheses into Achilles tendon defects in 16 white New Zealand rabbits. We established the following three experimental groups based on the replacement substitutes used: group I (silk scaffold alone); group II (composite silk scaffold); and group III (composite silk scaffold ensheathed in a human amniotic membrane). Implants were harvested 2, 8, and 12 weeks post-implantation. Histological examinations were conducted using hematoxylin-eosin, Masson’s trichrome, and by performing immunohistochemical staining for CD34. Tenocytes were cultured in vitro to compare cell populations in the three groups.