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Synthesis and functionalization of graphene and application in electrochemical biosensing

Abstract Graphene is a two-dimensional material with amazing characteristics, which grant it the title “wonder material”. It has grabbed appreciable attention due to its exceptional electrical, optical, thermal, and mechanical properties. Because of these interesting properties, graphene has found its way into a wide variety of biosensing applications. It has been used as a transducer in electrochemical biosensors, bio-field-effect transistors, impedance biosensors, electrochemiluminescence, and fluorescence biosensors. Functionalization of graphene has further opened up novel fundamental and applied frontiers. The present article reviews recent works dealing with synthesis, functionalization of graphene, and its applications related to biosensors. Various synthesis strategies, mechanism and process parameters, and types of functionalization are discussed in view of biosensor development. Some potential areas for biosensor-related applications of functionalized graphene are highlighted, including catalytic biosensors and bio affinity biosensors. Wherever applicable, the limitations of the present knowledgebase and possible research directions have also been discussed.