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Epileptiform Activity Induced by Pharmacologic Reduction of M‐Current in the Developing Hippocampus in Vitro

Summary:  Purpose: Benign familial neonatal convulsions (BFNCs), an inheritable epilepsy that occurs in neonates but not in adults, is caused by hypofunctional mutations in genes codifying for the M‐type K+ current. In an attempt to develop an in vitro model of this disease, we tested whether blocking M‐current with linopirdine induces epileptiform activity in brain slices from animals of different ages.