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Effects of Direct Hemoperfusion Using a Cytokine-Adsorbing Column on Endotoxin-Induced Experimental Acute Lung Injury in Rats

Background: Effects of direct hemoperfusion with a cytokine-adsorbing column, CTR, on endotoxin-induced experimental acute lung injury in rats were evaluated. Methods: 36 Sprague-Dawley rats were ventilated mechanically and allocated to one of the following three groups (n = 12 per group): saline control, saline instilled into trachea; endotoxin control, endotoxin (40 mg/kg) instilled into trachea, and treatment group, CTR treated for 90 min after endotoxin (40 mg/kg) instillation. Blood gases, cytokine concentrations and lung histopathology were evaluated. Results: The decreased PaO2 in the treatment group had recovered at 120 min after instillation and was significantly higher than that in the endotoxin control. The increased PaCO2 in the endotoxin control was significantly higher than that in the treatment group. The elevated cytokine concentrations and the neutrophil infiltration into the lungs were less in the treatment group than in the endotoxin control. Conclusion: The present study showed that CTR treatment inhibited hypoxia, hypercapnia, and inflammatory responses in an acute lung injury model.