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The roles of Th1 and Th17 cells in multiple sclerosis and experimental allergic encephalomyelitis

Multiple sclerosis is a T-cell-mediated autoimmune demyelinating disease of central nervous system.Experimental autoimmune encephalomyelitis is an animal model of multiple sclerosis.Conventional wisdom is that T helper type 1 (Th1) cells were thought to be the main effector T cells responsible for the autoimmune inflammation.However,The discovery of Th17 cells has challenged the critical roles of Th1 cells.In view of this,the functions of Th1 and Th17 cells in multiple sclerosis and experimental allergic encephalomyelitis research are reviewed here. 
 
Key words: 
Multiple sclerosis;  Experimental allergic encephalomyelitis;  Th1;  Th17