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Temporal Variations in Carcinogenic Effects

tumour. Angiosarcoma of the liver induced by vinyl chloride monomer (VCM) has a much shorter average and minimal latent period than that induced by ’Thorotrast’ (thorium dioxide), a conclusion based on pooled data from West Germany, the United Kingdom, Denmark and the United States of America, reported since 1947 (Thorotrast) and 1974 (VCM) (see Figure 1). The authors point out that not all of the cases that might be expected to occur from exposures to these compounds have yet appeared. There are different periods of observation as Thorotrast exposure occurred mainly between 1928 and 1955 and VCM exposures were heaviest from 1940 to the 1960s, but these differences together do not appear to alter the conclusion that VCM-related cases occur much