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The activity of γ‐glutamyltransferase and the histology of the liver of Hybro chickens treated with chromimum (VI) and vitamin C.

In this study the effect of interaction of both vitamin C and chromium (VI) on the activity of γ‐glutamyltransferase (GT) on serum as well as histological structure of the liver of Hybro chicken was investigated. The activity of this enzyme is closely connected with liver and bilary channels’ disease. The chickens were divided into five groups (I–V) each consisting of 10 chickens, which were treated orally for six months with different concentration amounts of chromium (VI) and vitamin C. Our investigation shows that 6 months administration of two different concentration amounts of chromium (VI), resulted in non‐significant increase of γ‐GT activity and slight histopathological changes in liver, e.g. vacuolization of hepatocytes, infiltration of limphoplazmocytes around biliary channels and the central vein, proliferation of biliary ducts, desquamated cells and extravasated erythrocytes in some areas, etc. Histological findings in liver show that there is a slight difference between the chickens treated with chromium (VI) and vitamin C and of those of control group, whereas there is an increase of the activity of γ‐GT among the treated chickens compared to those of control group.