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Significant upgrading affects a third of men diagnosed with prostate cancer: predictive nomogram and internal validation

To explore the rate of significant upgrading from biopsy to radical prostatectomy (RP) specimens in a contemporary cohort, and to develop a prognostic model capable of predicting the probability of significant upgrading, as previous reports indicate that up to 43% of men with low‐grade prostate cancer at biopsy will be diagnosed with high‐grade cancer at RP.