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Cerebrovascular effects of nebulized nitroprusside (Neb-NP) during hypoxia-induced pulmonary hypertension in piglets ♦ 336

Intra-pulmonary administration of nitric oxide (iNO) or nitric oxide analogs such as nitroprusside produces selective pulmonary vasodilation. However, nitric oxide has been implicated in control of the cerebral as well as the pulmonary circulation. We tested the hypothesis that Neb-NP (a user-friendly analog of iNO) would adversely affect the cerebral circulation while improving pulmonary artery pressure (PAP) during hypoxia-induced pulmonary hypertension in piglets.