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Orally and rectally administered streptokinase. Investigation of its absorption and activity.

The absorption and activity of orally and rectally administered streptokinase was investigated. No difference was found between the levels of plasminogen activators and antistreptokinase antibodies before and after oral or rectal administration of streptokinase-streptodornase (Varidase), nor was there any difference in the hematoma resorption times between patients treated with oral streptokinase and a control group. We found no evidence of streptokinase absorption or increased fibrinolytic activity in plasma after oral or rectal administration in our patients.