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Regulation by dexamethasone and 1,25-dihydroxyvitamin D3 of the 75 kD-type A tumor necrosis factor receptor surface expression and mRNA level in human U937 cells.

1. Dexamethasone selectively reduced the number of the type A (75 kD) receptors whereas 1,25-dihydroxyvitamin D3 reduced the number of both A (75 kD) and B (55 kD) receptors, without any change of their dissociation constants (3-4 x 10(-10) M and 1-2 x 10(-9) M respectively). The level of the type A (75 kD) TNF receptor mRNA was increased following treatment with either steroid. 2. Other agonists which either down-regulated (phorbol dibutyrate) or up-regulated (dibutyryl cAMP and recombinant GM-CSF) rTNF alpha binding also increased the level of this mRNA species. 3. The data suggest that these steroids might alter post-transcriptional event(s).