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Profiling the Post‐Injury Hippocampal MicroRNA Response to Transient Forebrain Ischemia: Sub‐regional Differences Between Cornu Ammonis‐1 and Dentate Gyrus

Even brief periods of ischemia can result in delayed neuronal cell death in hippocampal cornu ammonis‐1 (CA1), resulting in impaired memory and learning, whereas neurons in the adjacent dentate gyrus (DG) are relatively ischemia resistant. Understanding the pathophysiological and molecular mechanisms underpinning the selective ischemic vulnerability of the CA1 may translate to novel clinical interventions improving outcome in survivors of cerebral ischemia. MicroRNAs (miRNAs) are short (~18–25 nucleotides long) non‐coding RNAs that modulate translation of target messenger RNAs. To date, the miRNA expression profiles of hippocampal CA1 and DG sub‐regions in response to forebrain ischemia have not been examined. The objective of the present study was to assess and compare post‐injury miRNA expression patterns between CA1 and DG in a rat model of forebrain ischemia.