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No association of both serum pro‐brain‐derived neurotrophic factor (proBDNF) and BDNF concentrations with depressive state in community‐dwelling elderly people

Brain‐derived neurotrophic factor (BDNF) is involved in emotional and cognitive function. Low‐BDNF levels occur in patients with depression, while proBDNF, a precursor of BDNF with the opposite physiological function, increases in major depression. However, it is unclear whether BDNF and proBDNF are associated with depression in the elderly. The present study aimed to investigate whether serum proBDNF and BDNF are associated with depressive state in community‐dwelling elderly people.