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Relationship between the microsatellite D2S388‐5 and D2S2232 polymorphisms and chronic obstructive pulmonary disease in the Chinese Kazakh population

Background and objective:  Chronic obstructive pulmonary disease (COPD) is influenced by multiple genetic and environmental factors. The role of genetic susceptibility in the pathogenesis of COPD has recently gained more attention. The surface lung surfactant protein B plays an important role in COPD pathogenesis. Microsatellite DNA has been characterized in the surfactant protein B alleles D2S388‐5 and D2S2232. The aim of this research was to investigate the distribution of the D2S388‐5 and D2S2232 microsatellite polymorphisms in smokers of the Kazakh ethnic group in Xinjiang, China, with and without COPD to assess whether such polymorphisms are associated with COPD susceptibility.