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Coronavirus dons a new crown

A transmembrane pore reveals parallels with other viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), belongs to the positive-strand RNA [(+)RNA] viruses, a large class of viruses that includes Zika, hepatitis C, and chikungunya viruses. (+)RNA viruses package their genomes in infectious virions as messenger-sense RNA and reproduce these genomes solely through RNA intermediates in replication complexes (RCs) formed by rearranging intracellular membranes (1). RNA replication is a major target of antiviral drugs, including remdesivir, which shows promise for treating COVID-19 patients. RCs of coronaviruses and some other (+)RNA viruses are ∼250- to 300-nm-diameter double-membrane vesicles (DMVs) that contain viral double-stranded RNA (dsRNA) replication intermediates (2–4). On page 1395 of this issue, Wolff et al. (5) identify a crown-like double-membrane–spanning molecular pore on SARS-CoV-2 and other coronavirus DMVs that likely solves the longstanding problem of how progeny (+)RNA genomes are released from DMVs.