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Salivary gland cancer: assessing elusive behavior

Primary salivary gland neoplasms are rare and are known for their varied phenotypic and biological presentations and behavior. They originate from three major, and numerous minor, salivary glands mainly in the head and neck region. The vast majority of these tumors are benign and are managed successfully by surgery alone [1]. Approximately 30% of salivary neoplasms are malignant and may commonly cause considerable diagnostic and management challenges [2,3]. This remarkable interand intra-tumoral heterogeneity has stymied efforts to predict the biological behavior, and improve their management of salivary gland neoplasma. This editorial addresses the histogenesis, biological hetero geneity and current molecular findings in salivary gland malignancies in the context of their biological behavior and future management.