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Endothelium in polycythemia secondary to obstructive lung disease.

The object of this editorial is the report of Boyer et al in this issue of the Journal of Applied Physiology .It has two merits. One, endothelial function was studied in individuals with polycythemia secondary to obstructive lung disease, a condition not commonly addressed by cardiovascular investigators, although its presence is associated with a clearcut increase in cardiovascular risk .Two, the authors made use of virtually all techniques available in man to determine endothelial-dependent modulation of vascular tone, an unusual effort that differentiates this study from most other studies so far published. The results provide evidence that in polycythemic patients with obstructive lung disease the forearm vasoconstriction induced by L-NMMA administration was not reduced as compared to controls, while the brachial artery dilatation in response to post-ischemic hyperemia was increased.