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Alzheimer 's disease - Recent Advancement in Neuroscience Research

Alzheimer’s disease also known as dementia is one of the widely affective neurodegenerative disorder only after Parkinsonism. The patients suffering from Alzheimer’s disease has increased dramatically over a period of time. This has propelled the interest of neuroscientists to develop new drug therapies to combat this disease. The drugs available are not effective in permanently curing the disease, but effective in mostly reducing the symptoms of the disease and delaying its progression. This review has been produced by probing relevant publications, PubMed and Medline articles. The Pharmacotherapy revolves around two drugs, Acetylcholinesterase Inhibitors which are most effective in treating mild, moderate and severe form of Alzheimer’s disease. The other drug being Memantine, NMDA receptor antagonist which has been effective in combination with Acetylcholinesterase Inhibitors in moderate to severe form of Alzheimer’s disease. The underlying pathophysiology of Alzheimer’s disease is not very clear. Contemporarily there has been alarming advancements in the pathophysiology of Alzheimer’s disease which provided the gateway for neuroscience research in determining the most favourable investigational treatments which includes Passive and Active immunization techniques against Amyloid-β-protein and development of β and γ secretase inhibitors.