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Antigenic structure of foot and mouth disease virus.

This paper stresses the importance of relating antigenic properties of FMD virus, determined by serological and biochemical tests, to immuno­ genic properties. Factors involved in protection, other than those involving neutralisation as measured in vitro, are discussed. A generalised model for FMD virus is proposed and the implications of the topology of the antigenic sites on the binding and subsequent effects of binding of antibodies, are high­ lighted. Evidence to support the theoretical treatment is provided from studies using monoclonal antibodies. The use of such reagents for the identification of epitopes and the determination of biological functions associated with anti­ gens is discussed.