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Protective effect of n-butanol extract of Nyctanthes arbor-tristis on antioxidant tissue defence system against doxurubicin induced cardiotoxicity in rats

Objective: The present investigation aims to study the protective role of n-butanol extract of Nyctanthes arbor- tristis on antioxidant tissue defense system against doxorubicin induced cardiotoxicity in rats. Methods: Wistar rats were divided into various treatment groups. Doxorubicin (3mg/kg, i.p.) (DOX) was used to induce cardiotoxicity. N-butanol extract of Nyctanthes arbor-tristis (100 and 300 mg/kg, p.o.) and Vitamin E (25 mg/kg, p.o.) were administered for 15 days. ECG changes, biochemical parameters (LDH, SGOT, CPK), relative organ weight, antioxidant levels (SOD, GSH, LPO) and histopathological changes were recorded at the end of treatment schedule. Results: DOX treated animals showed elevation of QRS complex and a significant (p<0.05) elevation in levels of SGOT, CPK, LDH and LPO and a significant (p<0.05) reduction in relative organ weight, GSH and SOD. Histopathological changes like nuclear changes, vacuolated myocytes, cell necrosis, dilated vessels, partial loss of myofibrils were observed in the DOX treated group. Animals co-administered with n-butanol extract of Nyctanthes arbor-tristis (100 and 300 mg/kg, p.o) and vitamin E (25 mg/kg, p.o.) in DOX treated animals showed significant (p<0.05) protection of all the above parameters as compared to DOX treated animals alone. Conclusion: The beneficial effect of Nyctanthes arbor-tristis against cardiotoxicity could be attributed to its antioxidant potential.