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The origin of variability of anatomic tone, heart rate, and systolic blood pressure (879.15)

Background: Since 2011, we introduced theory system of holistic integrated control/regulation of life. “Lung inspiratory and expiratory ventilation results continuous dynamic up-down change of PO2 and PCO2 in alveoli, then similar changes of PaO2, PaCO2 and [H+]a, which stimulate peripheral (fast) and central (slow) chemical receptors to control and regulate breath and circulation”. Variability of HR, SBP and anatomic tone normally follows the breath rhythms. However, mechanism is unclear. We use the continuous dynamic change in of PaO2, PaCO2 and [H+]a via neurohumoral system to explain variability of HR, SBP and anatomic tone. Theoretical explanation: Alveolar gases pressures continuously go up/down during lung inspiratory and expiratory period. The signals of these changes of lung/alveolar PO2 and PCO2, go to arterial side following blood flow, via peripheral (fast) chemical sensors and nerve system directly and indirectly to result variability of anatomic tone, HR and stroke volume (SV). Based upon th...