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High Throughput Tender 3D X-ray Imaging of Cells for Correlative Microscopy

X-ray microscopy has emerged in the past few years, driven by intrinsic advantages of nondestructive high resolution imaging and enabled by major advances in high-resolution x-ray optics and sources. The technique has become the leading 3D nano-imaging approach for intact cells in their native or nearnative hydrated state [1] and has facilitated bridging the critical resolution gap between electron and light-based approaches (Fig. 1) [2].