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Cerebral hemodynamics and cognitive decline

The aging of our population means the incidence of cognitive impairment will continue to rise over the next decades, bringing urgency to our obligation to unravel this condition's complex pathophysiology. The prevailing conception about diseases such as Alzheimer dementia, stroke, and frontal temporal dementia is that progressive cognitive dysfunction, once identified, is an irreversible process, leading inexorably to a state of total dependence, and to family and societal burden. Any advance in our knowledge, including the prospect that cognitive decline may have a potentially treatable pathophysiology, creates some light in an otherwise apparently dark tunnel.