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Plant Substances As Antiviral Agents



Among the numerous compounds that have been reported to exhibit potent antiviral activity in cell cultures and/or in experimental animals are several natural products isolated from higher plants. Some of these plant compounds exhibit an unique antiviral mechanism and are good candidates for further clinical research.


In this review, an approach to the isolation of potential antiviral plant agents and lead compounds is outlined. A discussion of plant selection, followed by a description of antiviral testing, both in vitro and in vivo, is also given. The importance of the plant kingdom as a source of potent antiviral lead substances will be illustrated by presenting a survey on plant-derived anti-herpes virus and anti-human immunodeficiency virus agents.

