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[Structure and cytophysiology of gastric endocrine gland cells after repeated administration of testosterone propionate].

By means of light, electron microscopy and morphometry methods contents and structural organization of endocrinocytes have been investigated in gastric glands of rats, to whom testosterone propionate has been injected for 5, 10, 15, 20 days. The hormone produces certain stimulating effect on the endocrine apparatus function. During the first stages of the experiment most of the endocrinocytes are at the state of active secretion; this is testified as a decreasing composition of histochemically revealed cells in epithelium and their degranulation. During the following stages the process of synthesis is activated in the cells and their amount increases. Appearance of numerous agranular, poorly differentiated endocrinocytes and exo-endocrine cells demonstrates certain intensification of cytogenesis of endocrinocytes in the gastric epithelium. The changes observed are considered as adaptive, directed to stabilize homeostasis, when the hormonal balance is disturbed.