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MicroRNA let-7e AND miR-140 AS BIOMARKERS OF DEFORMING JOINT DISEASES

The circulating microRNAs (let-7e and miR-140) expression levels were studied in the plasma of peripheral blood and synovial fluid of patients with gonarthrosis and coxarthrosis. There was a statistically significant decrease in the expression of miR-140 in synovial fluid and let-7e in the peripheral blood of patients with osteoarthritis (p <0.05). MicroRNA let-7e characterizes comorbidity and indicates the development of metabolic syndrome. It was established a correlation between the microRNAs expression levels and the disease severity.