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Effect of Gastrin on Electrical Activity of Antrum and Duodenum of Dogs

Summary In dogs with electrodes chronically implanted on the stomach and duodenum, graded doses of intravenously infused synthetic human unsulfated little gastrin (G17-I) produced, in both the stomach and duodenum, graded increases in a) frequency of pacesetter potential, and b) incidence of pacesetter potentials with action potentials. The threshold doses of gastrin for these effects were about 25 pmol kg-1 h-1 in the stomach and about 50 pmol kg-1 h-1 in the duodenum. These doses of gastrin are similar to the threshold dose for gastric acid secretion.