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Activation energies for water diffusion in ex-vivo white matter

Introduction: Diffusion in brain tissue is well known to be non-Gaussian, resulting in major efforts to understand the biophysical basis of water mobility in such tissues [1]. This study aims to understand the energetics of differently diffusing components by quantification of their respective activation energies. When temperature is varied, self-diffusion in pure liquids follows the Arrhenius law, D(T)=D0 exp(-Ea/RT), where Ea is the activation energy for diffusion D(T), and R is the universal gas constant [2]. This equation can be fitted for each diffusion component.