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Effects of Prazosin on Human Fat‐Cell Lipolysis and Adenylate Cyclase Activity In Vitro

The effects of prazosin on adrenergie-stimulated fat-cell lipolysis and adenylate cyclase activity were investigated. The results revealed that the antilipolytic alpha-adrenergic catecholamine effects on human fat-cell metabolism are mediated via alpha-receptor sites displaying extremely low affinity to prazosin, which is alpha,-site selective. The data provide an explanation for the lack of effect of prazosin on lipid mobilization in viva. The molecular sites mediating the lipid-lowering action of the drug, however, remain to be elucidated