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Interactions between inhibitors of the axonal amine pump and bretylium in the degeneration release of sympathetic transmitter.

Lundberg, D. Interactions between inhibitors of the axonal amine pump and bretylium in the degeneration release of sympathetic transmitter. Acta physiol. scand. 1970. 78. 503–521. 
 
 
 
The time course of the degeneration contraction of periorbital smooth muscles has been studied in conscious rats given different inhibitors of the axonal mine pump either alone or in combination with bretylium. Desmethylimipramine (DMI) or cocaine at 20 mg/kg did not influence the time of onset of the degeneration contraction while Lu 3–010 (10 mglkg) caused a somewhat premature start. Lu 3–010, DMI or protriptyline at 10 mg/kg but not trimipramine or cocaine at 20 mglkg antagonized bretylium. They reduced and prevented (DMI) the bretylium-induced delay. DMI reduced the delay by a non-competitive mechanism. The antagonism to bretylium does not seem to be explainable by simple interference with the axonal amine pump. Indirect evidence suggests that the duration of the delay induced by bretylium is related to the rate of disappearance of bretylium from critical sites in the nerve endings. –DMI and Lu 3–010 seem to have somewhat different actions on the degenerating adrenergic nerve terminals.