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Expression of interleukin (IL)‐4 and IL‐5 proteins in asthma induced by toluene diisocyanate (TDI)

Background TDI‐induced asthma exhibits clinical, functional and morphological similarities with allergen‐induced asthma, suggesting that an immunological mechanism is involved in the sensitization to TDL In vitro studies using the technique of cloning lymphocytes demonstrated that a great proportion of T‐cell clones derived from bronchial mucosa of subjects with TDI‐induced asthma produced IL‐5 and interferon‐gamma, but not IL‐4, upon in vitro stimulation.