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Total iron-binding capacity of plasma in normals and hyperthyroid patients, under oral overloading.

This study deals with the effects of altitude and hyperthyroidism on iron metabolism as measured by total ironbinding capacity, unsaturated iron-binding capacity, percentage iron saturation, and siderophilin determinations in patients who were fasting and who then ingested overloads of oral iron as ferrous gluconate (176 mg.). Neither altitude nor hyperthyroidism had a demonstrable effect on the values listed above; however, normal as well as hyperthyroid patients showed significant changes in unsaturated iron-binding capacity and percentage iron saturation after oral ferrous gluconate overloading, when the mean fasting values were compared with the values obtained 2, 4, and 6 hr. following ingestion of the iron.