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Comorbidity Effects of Mitochondrial Dysfunction to the Progression of Neurological Disorders: Insights from a Systems Biomedicine Perspective

Mitochondrial-dysfunction is linked to various neurological diseases. To understand these complications we developed a quantitative framework to explore how mitochondrial-dysfunction influences the progression of Alzheimer’s, Parkin-son’s, Huntington’s, Amyotrophic Lateral Sclerosis and Cerebral Palsy. We sought insights from the gene profiles of mitochondrial and associated neurological disorders by constructing gene-disease networks. We also employed KEGG pathways and Gene Ontology to explore functional enrichment, and protein-protein interaction networks to identify the protein groups shared between these diseases. These identified potential biomarkers were verified using gold-benchmark databases. Our identified signature genes and pathways are useful to identify co-morbidity outcomes for the mitochondrial dysfunction.