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The effect of surgery on natural killer cell activity in head and neck cancer patients: In vitro reversal of a postoperatively suppressed immunosurveillance system

Curative surgery diminished natural killer (NK) cell activity in 17 patients with previously untreated squumous cell carcinoma of the head and neck (37% ± 17%, preoperatively vs. 21% ± 11%, postoperatively; p<0.001). this operatively induced suppression was dependent on the presence of a nylon wool adherent cell population. with the removal of this surgically generated suppressor population from the in vitro assay, postoperative suppression of natural killer activity was significantly diminished (21% ± 13%, vs. 30% ± 23%, p<0.01). the capability of fully restoring postoperatively suppressed nk cell activity was subsequently demonstrated by the synergistic effect of removing a nylon wool adherent suppressor population and stimulating nk cells with a naturally occurring immunopotentiator, tuftsin (from 21% ± 13% to 41% ± 23%; p <0.0001).