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[Effect of penicillamine therapy on the concentration of zinc, copper, iron, calcium and magnesium in the serum and their excretion in urine].

The application of Penicillamine (750 mg per day) for one year resulted in the expected increase of urinary copper excretion (8-10 fold). The increase of Zinc excretion was only moderate (2 fold). The application of Penicillamine did not influence the excretion of Ca, Mg and Fe. We did not find a decrease of Zinc content in the hair of patients after one year treatment. The serum concentration of Zn, Cu, Fe, Ca and Mg was not influence by the application of Penicillamine. Thus, a treatment with Penicillamine is not a probable cause of zinc deficiency in liver disease.