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ANÆMIA IN THE UPPER WATUT VALLEY OF NEW GUINEA A STUDY OF THE EFFECTS OF ALTITUDE AND SPLENOMEGALY ON HÆMOGLOBIN LEVELS

Hæmoglobin estimations were performed on 1,095 inhabitants of the Upper Watut Valley of New Guinea, where the tropical splenomegaly syndrome is particularly common. The subjects studied lived between the altitudes of 3,300 and 5,200 feet above sea level. In men, women and children an increase in mean hæmoglobin level occurred in association with an increase in altitude, but only in those with minor degrees of splenomegaly. Increasing spleen grade, on the other hand, was accompanied by a significant fall in mean hæmoglobin level at all altitudes and in all subject groups. Thus anæmia was more common in those with marked splenomegaly, but over 50% of subjects without palpable splenomegaly also had subnormal hæmoglobin levels.