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Immunoglobulin (IgA) deficiency in systemic lupus erythematosus. Report of a case and family studies.

SummaryA woman with an idiopathic convulsive disorder developed systemic lupus erythematosus (SLE) while on dilantin treatment. The patient's serum was IgA-deficient, a finding which prompted study of all available members of her family. Among 14 relatives, low to absent IgA levels were found five times suggesting a genetically determined pattern of IgA deficiency. Various clinical and laboratory data of the patient and her family are presented.