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[Genetic aspects of hypertrophic cardiomyopathy (familial studies and relation of HLA to obstructive hypertrophic cardiomyopathy)].

The purpose of the paper was to study the families of 31 patients with hypertrophic cardiomyopathy (HCMP) to establish the hereditary nature of disease as well as to study the peculiarities of distribution of HLA-A, B and DR antigens in 44 patients (Russians) with obstructive HCMP using a method of histocompatibility typing. Echocardiographic investigation of 105 relatives of 31 patients with various types of HCMP revealed 32 patients with the same pathology among 84 persons in 20 families suggesting the familial pattern of disease. Antigen markers of predisposition to obstructive HCMP were established: HLA-B27, DR1 and DR4. DR4 antigen has primary relationship with the disease. Some differences in the distribution of HLA-antigens in men and women with obstructive HCMP were revealed. There was no correlation of HLA-markers with the severity of disease and patient's age at which the disease developed.