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Low prevalence of hepatitis C virus and infrequent perinatal or spouse infections in pregnant women in Taiwan

To assess the prevalence of hepatitis C virus (HCV) infection in the pregnant women in Taiwan, we investigated two groups of pregnant women, 944 women without serum alanine aminotransferase (ALT) screening (group A) and 197 women with abnormal ALT (>45 IU/L) (group B). They were checked for anti‐HCV (anti‐C100‐3) with HCV EIA kit (Abbott Lab., North Chicago, IL). The results showed that 21 (2.2%) in group A and 5 (2.5%) in group B were anti‐HCV‐positive. However, 15 out of 21 in group A had an optical density (O.D.) of anti‐HCV <1.0, were negative by recombinant immunoblot assay (RIBA), and were regarded as false‐positive.