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The influence of renal papillary urea concentrations and of plasma vasopressin on the urinary prostaglandins E2 and F2 alpha excretion in conscious rats in steady state of urine formation.

Urinary excretion rates of PGE2 and PGF2 alpha were measured radioimmunologically in four different groups of unanaesthetized rats: water diuretic rats (I), rats with free access to water (II), water deprived rats (III) and 1.5% saline-loaded rats (IV). The animals were decapitated when steady states of urine formation were ascertained for three to six spontaneously delivered urine portions. Plasma vasopressin was measured radioimmunologically and urea, sodium, potassium concentrations and osmolalities of papillary fluids and of bladder urines were determined. Group means of urinary prostaglandin excretion, papillary urea concentration and logarithmic-transformed plasma vasopressin values vary in parallel for three of the groups (I, II and III) but a dissociation of the effects of papillary urea and vasopressin on the prostaglandin excretion was obtained for group IV. Statistical analyses indicated that the differences in prostaglandin excretion rates between group I and the three other groups are accounted for by the combined effects of vasopressin and papillary urea. The results support the hypothesis that vasopressin stimulates release of arachidonic acid in the papilla and that urea inhibits the trapping of this prostaglandin precursor in cellular lipids. The ratio of urinary PGF2 alpha to PGE2 varied greatly between groups but no consistent dependency on the measured parameters was found.