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[Nitrogen monoxide monitoring not useful in children with asthma].

Although the Dutch Paediatric Society 2007 practice guideline on asthma in children recommended monitoring of exhaled nitric oxide (FeNO) in the follow-up of children with asthma, a recent systematic review performed by the Dutch Cochrane Centre clearly showed that monitoring FeNO does not improve clinically-relevant asthma outcomes in children. As a result, FeNO monitoring cannot be recommended in the follow-up of children with asthma. This illustrates that many recommendations in evidence-based guidelines are not firmly based on high-quality evidence, but on expert opinion alone. This calls for caution in using such guidelines as standards of care.