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Lack of correlation between fatty acid oxidation disorders and haemolysis, elevated liver enzymes, low platelets (HELLP) syndrome?

Aim: Fatty acid β‐oxidation defects comprise a heterogeneous group of disorders that may precipitate acute life threatening metabolic crises particularly during catabolic episodes. Several studies have demonstrated a possible association between fatty acid β‐oxidation defects, including long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency and severe pregnancy complications. However, the precise percentage of women with haemolysis, elevated liver enzymes, low platelets (HELLP) syndrome associated with foetal fatty acid β‐oxidation defects is not known. Methods: We carried out a multicentre retrospective study on 88 infants, born to women with HELLP syndrome. Acylcarnitine profiles from blood dried on filter paper cards were analysed by tandem mass spectrometry for the diagnosis of fatty acid β‐oxidation defects. In addition, we screened for the common long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency mutation using a standard restriction fragment length polymorphism polymerase chain reaction method. Results: None of the infants studied carried the common long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency mutation. There was no evidence of fatty acid β‐oxidation defects, including long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency, as expected by unremarkable acylcarnitine profiles, while three infants with fatty acid β‐oxidation defects were diagnosed in the control group.