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EFFECT OF DIPHENYLHYDANTOIN ON CONNECTIVE TISSUE

Decreased collagen biosynthesis by 10‐day‐old chick embryo tibiae was observed under the influence of sodium diphenylhydantoinate. A complex was formed by the drug and ferrous or ferric ions. An inhibition of the hydroxylation of 14C‐proline and 14C‐lysine may be a consequence of the binding of ferrous ions to the drug. In addition, a decreased incorporation of 14C‐glucosamine was observed. A hampered collagen biosynthesis has also been observed to be effected by other drugs capable of producing a lupus‐like syndrome.