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Need for long term safety studies before recommending viral vector vaccines in kids

Vaccines have played a central role in dealing with COVID-19 pandemic. Now regulatory agencies in USA and around the world have begun approving vaccination for kids. Long term safety profile of live attenuated viral vaccines, inactivated viral vaccines and peptide-based vaccines are well studied in children, are safe and can play a central role in controlling the spread of COVID19 in children. But the long-term safety profile of viral vector-based vaccines is not studied. In the present correspondence we highlight the possibility of random insertional mutagenesis and potential side effects, which might be evident after long-term.  Regulators must take into consideration the possibility of insertional mutagenesis and conduct long term studies before approving the viral vector vaccines in children, so that the public have trust in the regulatory agencies and are compliant towards vaccinating their children with safe and effective vaccines.