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Reproducibility of T-wave morphology assessment in patients with hypertrophic cardiomyopathy and in healthy subjects

This study examined the reproducibility of T-wave morphology assessment in 54 patients with hypertrophic cardiomyopathy (HC) and 70 healthy subjects (HS). Studied indices included: the total cosine R-to-T (TCRT), T-wave morphology dispersion (TMD) and normalized T-wave loop area (TLA). The reproducibility was assessed by coefficient of variance (CV) and ratio of individual range to total range of the measurements (RA). In supine position, significantly smaller measurements of TCRT while significantly greater TMD and decreased TLA were found in HC compared to HS (p<0.01). RA and CV were low in both HS and HC There was no significant difference in RA or CV between HC and HS. In standing, the same pattern in T wave morphology measurements was found. All measurements tended to be more variable in standing position. Computerized measurements of T-wave morphology are highly reproducible and may provide a reliable assessment of repolarization abnormalities.