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Reliability and usefulness of the fitting of a modified gamma function to time-activity curves by means of a non-linear iterative least-square method.

A non-linear iterative least-square fitting method is presented for calculating the parameters of a modified gamma function. The method permits the correction of the appearance time (AT) and the curve parameters in those situations in which AT cannot be estimated with accuracy. The reliability and accuracy of the method is studied in experimental and simulated curves by means of a computer, comparing the results with those obtained by the method of Starmer and Clark for different initial selections of AT and noise at the base line. The usefulness of the method is shown in situations where the curves are distorted in their initial part.