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[Primary sclerosing cholangitis: modern concepts].

This review deals with primary sclerosing cholangitis (PSC) as a challenging problem in gastroenterology. Definition of PSC is presented, its putative pathogenetic and etiological factors, clinical symptoms, complications and concomitant disorders, methods of laboratory and instrumental diagnostics are described. Special attention is given to modern approaches to the treatment of the disease, dietoherapy, pharmacotherapy, auxiliary therapeutic modalities, indications for liver transplantation and its outcomes.