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Interleukin‐1 Gene Complex in Schizophrenia: An Association Study *

The aim of this study is to investigate the association between three polymorphisms of the interleukin‐1 (IL‐1) gene complex and schizophrenia. We genotyped 228 outpatients with schizophrenia (DSM‐IV criteria) and 419 unrelated healthy controls. The following polymorphisms were analyzed: IL‐1α −889 C/T, IL‐1β +3953 C/T, and IL‐1RA (86 bp)n. No significant differences in genotype or in allelic distribution of the Il‐1α, IL‐1β, and IL‐1RA polymorphisms were found. Estimated haplotype frequencies were similar in both groups. Our data do not suggest that genetically determined changes in the IL‐1 gene complex confer increased susceptibility for schizophrenia. © 2005 Wiley‐Liss, Inc.