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PP.19.24: RELATIONSHIP BETWEEN BLOOD PRESSURE LEVELS AND LIPIDS FATTY ACID COMPOSITION IN PATIENTS WITH HYPERTENSION AND OBESITY

Objective: The aim of the study is to determine relationship between profile of BP monitoring and lipid metabolism in hypertensive patients with concomitant obesity. Design and method: We examined 78 (21f + 57 m) pts, age 48-73 years, with moderate arterial hypertension studied by BP monitoring and concomitant obesity (BMI - 35.9 kg / m 2) that had started 6.2 + 1.12 years before BP changes were revealed. Hypertension in the main group lasted from 4 to 16 years, the same observed in the obesity group (p > 0.05). The control group consisted of 45 pts with hypertension and normal body weight. The level of total cholesterol, with an analysis of gas-liquid chromatography of the fatty acids (FA) spectrum of the low density lipoprotein (LDL) and their content identification in ratio percentage of eight FA (saturated, unsaturated, polyunsaturated), were examined in all patients. Results: Total cholesterol level of less than 5.2 mmol/l was found in 26 vs 7 pts, while the level of more than 6.18 mmol/l – in 15 vs 5 pts. The spectrum of FA of LDL revealed an increase in saturation of LDL-lipid complexes in both groups. The growth of the saturated palmitic FA increased from 1.33 (main group) to 1.5 (control one), compared to the level of a healthy person (p < 0.05). During daily monitoring, decreased saturation of the unsaturated PUFA bond was accompanied by negative correlation with the BP levels (r = - 0.3,p < 0.05); the linoleum FA decreased 1,5 times, arachidonic – 2 times in the main group, while in the control group the levels of these FA were reduced by three times (p < 0.05) compared to healthy subjects. Conclusions: We have identified pathological changes of the qualitative composition of serum of highly atherogenic lipoproteins in hypertensive patients with normal body weight and in the patients with concomitant obesity, both with normal levels of total cholesterol and with excess levels. Different levels of unsaturation of polyunsaturated FA (PUFA) in the studied complexes of both groups may be contributed to the progression of hypertension, obesity, and atherosclerosis.