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Acceleration of re-entrainment during a 6-h acute jet lag simulation by 5-hydroxy-l-tryptophan in pygmy field mice

L-5-Hydroxytryptophan (5-HTP), the precursor of serotonin, is known to cause temporally differentiated phase shifts. However, its effects on acceleration of re-entrainment have not been demonstrated before. We report significant acceleration of re-entrainment to a 6-h advanced light dark schedule by 50 mg/kg 5-HTP (∼8 transients reduced to ∼3 transients) injected at ∼ZT 6 in the nocturnal Indian pygmy field mouse, Mus terricolor. The mechanistic explanation is currently unknown, but this probably occurs through serotonergic phase and period modifications. 5-HTP is thus potentially useful as a chronobiotic in circadian rhythm disorders.