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Clinical course and complications in Hodgkin's disease.

A review of the clinical course and complications of Hodgkin's disease stresses the recently acquired knowledge on its modes of spread with particular emphasis on lymphatic and vascular dissemination. The available data supporting these pathways of progression are correlated with the clinical events in the course of this disease. The manifestations related to the tumor involvement of different organs as well as those representing the remote effects of this malignant process on different systems are considered. The nonspecific clinical manifestations, as well as hematologic, metabolic, and endocrine-like complications are surveyed. Finally, the interrelationship of Hodgkin's disease with various conditions characterized by immunologic aberrations is discussed.