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V2O5 Nanobelts Mimicking Tandem Enzymes Achieving Non-enzymatic Online Monitoring of Glucose in Living Rat Brain.

The continuous detection of glucose is signiﬁcant for revealing its role in the neuron protection and diagnosis of various diseases. In this study, for the first time, a non-enzymatic online optical detection platform (OODP) for glucose measurement in rat brain utilizing the tandem enzyme activity of V2O5 nanobelts is developed. V2O5 nanobelts was synthesized via a facile solvothermal strategy and for the first time it is found the V2O5 nanobelts possess dual enzyme-like activity, i.e. glucose oxidase (GOx)-like and peroxidase-like activity and can act as "tandem nanozyme". To investigate the mechanisms of GOx-like property, we built the adsorption model and the RPBE density functional calculations indicate that the glucose molecule can be adsorbed on the V2O5 plane. Based on V2O5 nanobelts mimicking tandem enzymes, an non-enzymatic online optical detection platform (OODP) for the continuous monitoring of glucose in rat brain was designed, which exhibit excellent stability, high selectivity, a wide linear detection range from 0.2 to 5 mM, and succeed in recording the cerebral glucose alterations in the calm/ischemia model. This facile but reliable non-enzymatic online optical glucose measurement not only can compare favorably with these natural enzymes based online electrochemical glucose analytical systems, but also its ready adoption with physiologists and pathologists will benefit for understanding the function of the brain and the pathogenesis of diabetes.