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A META ANALYSIS INSIGHT OF ORAL CILOSTAZOL IN REDUCING INTERMITTENT CLAUDICAIOTN IN PERIPHERAL ARTERIAL DISEASE

Introduction: The varied results of studies about oral cilostazol in improving mean walking distance of patients with intermittent claudication were controversial. In this study, we will report the meta-analysis of oral cilostazol in the management of intermittent claudication in peripheral arterial disease. The parameters that will be carried out was mean walking distance. Methods: A comprehensive literature search was done in Medline and SCOPUS. The parameters in this study were the rate of mean walking distance, representing intermittent claudication in the patients with peripheral arterial disease with given oral cilostazol therapy. Data were managed based on PRISMA guideline and statistical analysis was performed in Review Manager or Stata version 13. Results: In this meta-analysis, several studies were included in the DCB vs PTA comparison group, ten studies were included in the DES vs PTA comparison group, and one study was included in the DCB vs DES comparison group. ). It was shown a significant difference (improvement) of mean walking distance in cilostazol therapy than placebo. The mean walking distance was improved by 51 meters. Discussion: This meta-analysis proved that oral cilostazol was effective in reducing intermittent claudication in peripheral arterial disease. The mechanism was still unclear but supposed to be related to inhibition of platelet aggregation. Conclusion: Oral cilostazol effectively reduces mean walking distance, thereby reducing intermittent claudication symptoms in peripheral arterial disease.