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Assessment of hypothalamic-pituitary function in women after external head irradiation.

To account for hypopituitarism in patients who received 60Co head irradiation for nasopharyngeal neoplasia, hypothalamic-pituitary function was evaluated in 12 women, aged 19–40 yr, 1–13 yr after the irradiation. The hypothalamicpituitary area received a dose of about 6000–6500 rads. Serum basal LH and FSH levels as well as their responses to 25 µg iv LRH were measured by RIA and the results were compared with responses in the early follicular phase of 5 normal cycling women. In 8 of the 12 patients, serum LH, FSH, and PRL levels were also measured before and during the fourth day of clomiphene administration (100 mg/day for 5 days). Among the 12 irradiated patients, 3 had oligomenorrhea, 3 had amenorrhea, and 8 had galactorrhea. The mean basal LH (5.80 ± 0.68 mlU/ml) and FSH (6.23 ± 0.79 mlU/ml) levels and the mean LRH-stimulated peak for LH (31.33 ± 4.26 mlU/ml) and FSH (14.84 ± 1.80 mlU/ml) were significantly (P < 0.01) lower than those of normal controls. The magnitude of individual gonadotropin respo...