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Role of Phospholipase D in Actin Cytoskeletal Reorganization of Epithelium Cells

Phospholipase D (PLD) is involved in many intra/extra‐cellular signaling transduction processes. The signaling relay is achieved through the production phosphatidic acid (PA) and choline from phosphodiester hydrolysis of phosphatidylcholine. The PLD isoforms, PLD1 and PLD2, has been reported to be involved in epithelium cell tumorogenesis through cytoskeletal rearrangement, but the mechanism remains unclear. Our project investigates the potential role and mechanism that PLD has over actin cytoskeletal rearrangement during tumor progression.