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Src‐dependent phosphorylation of the EGF receptor Tyr‐845 mediates Stat‐p21waf1 pathway in A431 cells

Background:  Cell surface receptor for the epidermal growth factor (EGFR) and cytoplasmic tyrosine kinase c‐Src co‐operate in several cellular functions such as proliferation and apoptosis. Our previous studies have shown that ectopic expression of the adaptor protein p52shc or p66shc, but not p46shc, and EGF stimulation lead to the activation of c‐Src that is accompanied by phosphorylation of signal transducers and activators of transcription (Stat) in A431 cells.