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[Development of atopic disease in early childhood--predisposing factors].

In this study, we attempted to find factors which predispose infants to atopy. 200 unselected newborns were followed up to 3 years of age. Children with elevated cordblood IgE or positive family history developed atopic disease significantly more frequent (p less than 0.05, p less than 0.01). Parental smoking or formula feeding alone did not influence the frequency of subsequent atopic disorders. However, in combination with reduced cordblood CD8-cells atopy was observed significantly more often (p less than 0.05, p less than 0.025). Similar results were found in children with reduced cordblood CD3-cells, whose parents were smokers (p less than 0.01). These results suggest that factors which alone do not influence atopy can enhance each other to predispose atopic disease in early childhood.