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Study on ultrastructural changes of anterior pituitary in rats exposed to PEMW

The document is to observe the changes of ultrastructure of endocrine cell in anterior pituitary after being exposed to PEMW to explore the possible injury characteristics. 28 male Sparague-Dawley rats were divided into 4 groups (7 rats in each group), the control group was put in the boxes without irradiation. At 24 h after exposure to PEMW (E=100 kVmiddotm-1, 10000, 100000, 300000 pulses), the transmission electron microscope was used to observe the ultrastructural changes of anterior pituitary. The result showed that ultrastructures of anterior pituitary were obviously changed in irradiated groups at 10000 pulses, especially in prolactin cells and growth hormone cells, including evacuation of secretory granule, the mitochondrial vacuolization and distinct dilatation of endoplasmic reticulum. The injury gradually aggravate followed by pulses increase. The changes at 300000 pulses were the most severe. In conclusion, PEMW can lead injury to endocrine cells of anterior pituitary in rats, mitochondria and rough endoplasmic reticulum are the main injured organelles.