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Adams–Oliver syndrome in a newborn infant

Adams-Oliver syndrome (AOS) is a rare multisystem disease of unknown aetiology, characterized by combination of aplasia cutis congenita of the scalp region and terminal limb anomalies. We present a case of a newborn infant with AOS: aplasia cutis congenita with defect of toes, wide bilateral parietal bone defect, partial agenesis of the corpus callosum and atrial septal defect. Skin defect of the scalp had spontaneously healed with cicatricial alopecia. Child’s mother was also born with aplasia cutis of the scalp, but no other associated anomalies. Neonates with AOS should be checked for other anomalies, and during their growth should be regularly followed-up by a team of specialists.