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Single-Molecule Studies of DNA-Associated Motors

This chapter provides a quick introduction to the various uses of single-molecule approaches in the study of DNA–protein interactions. This field is a rapidly evolving one and we have not attempted to cover it in any systematic way. In the following chapters we provide examples of the type of questions addressed in the study of the interactions of DNA with three families of molecular motors: polymerases, helicases, and topoisomerases.