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The in vivo effects of concanavalin A on the cellular immune response in BALB/c mice. Inhibition of the delayed hypersensitivity reaction to tuberculin

The suppressive effect of concanavalin A (Con A) on the cell‐mediated immune response was demonstrated in BALB/c mice made immune to challenge with tuberculin. 400 μg of Con A administered intraperitoneally simultaneously with injection of antigen into the footpad of primed animals resulted in suppression of the delayed hypersensitivity reaction as detected by a sensitive radioisotopic footpad assay. If Con A was given in a dose of 100 μg three times weekly to normal mice being sensitized to tuberculoprotein, the maximum immune response following complete immunization was significantly suppressed but not abolished.