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[The reproductive characteristics of the tick-borne encephalitis virus in interspecific somatic hybrids].

The study dealt with features of tick-borne encephalitis virus reproduction in two series of interspecies somatic hybrids generated by fusion of transformed cells of Chinese hamster (Ag17) with human diploid fibroblasts (KM/3) and with pseudonormal cells of Indian deer (Muntiacus munjak) (KOM). The viral infection in hybrid Ag17 cells ran an acute course with cell damage, but in KM/3 and KOM cells virus multiplication was not accompanied by the development of cytopathic effect. Two other parameters of tick-borne encephalitis virus infection under study: the extent of infectious particles production and electroimmunochemical properties were found to be under control of genomes of different parental cells.