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Mouse Genome Informatics (MGI): The Ever‐Expanding Resource

As the model organism of choice for studying human development and disease, the laboratory mouse plays a pivotal role in modern biomedical research. The Mouse Genome Informatics (MGI) site, http://www.informatics.jax.org, provides integrated access to a suite of data on the genomics, genetics, gene expression, phenotype, and biology of the mouse. MGI contains data from published and unpublished sources, acquired through ongoing expert human curation and integrated data loads from the biomedical literature, genome centers and data repositories. Core data include gene characterization and functions, phenotype and disease model descriptions, DNA and protein sequence data, SNPs, genetic and physical mapping data, gene expression data, and comparative gene data. MGI supports structured vocabularies and ontologies including: Gene Ontology (GO), Mammalian Phenotype (MP), Anatomical Dictionary of Mouse Development, OMIM, InterPro, and PIR super families. Web‐based query forms let users create complex queries using standardized nomenclature for genes, alleles, transgenes, and strains and involving phenotypic, biochemical function and process, sub‐cellular location, expression, sequence, polymorphism, complex trait, strain and mapping data. MGI updates new data nightly and continually adds new datasets and enhances the user interface.