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High Fibrinogen and Platelets Correlate with Poor Survival in Gastric Cancer Patients.

OBJECTIVE
Gastric cancer (GC) is one of the most common malignant tumors in the world, and its incidence rate ranks the fourth in the world. Hyperfibrinogenemia and hyperthrombocytopaemia are often associated with malignancy and poor prognosis. The purpose of this study was to explore the relationship between high levels of fibrinogen and platelets and the clinicopathologic features and overall survival (OS) of gastric cancer.


METHODS
We enrolled a total of 341 gastric cancer patients from our hospital between January 2014 and January 2015. GC patients were retrospectively assessed using a Kaplan-Meier method and chi-squared to confirm a correlation between patient survival and levels of fibrinogen (FIB) and platelets (PLT).


RESULTS
Our results show that FIB levels were associated with tumor size, lymph node metastasis, and depth of invasion (P<0.05). Platelet (PLT) levels were associated with tumor size (P<0.05). High FIB and PLT levels were associated with poor survival (P<0.05).


CONCLUSIONS
High platelets and fibrinogen may have synergistic effects on patients with gastric cancer.