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The accuracy of commercial enzyme reference sera.

Commercial reference sera with enzymic activities stated by the manufacturers are available for the “standardization” or quality control of enzyme-activity measurements in the clinical laboratory. The accuracies of the stated activities of lactic dehydogenase, glutamic oxalacetic transaminase, alkaline and acid phosphatases, and amylase were assessed. One manufacturer’s stated activities were acceptable in six of seven instances and another’s in two of three instances. Notably, the activities stated by six of the eight manufacturers were doubtful or unacceptable in more than 50% of instances. Most of the stated activities of commercial enzyme reference sera at present are reliable for neither standardization nor quality control.