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Bioactive Antiinflammatory Antibacterial Antioxidative Silicon-Based Nanofibrous Dressing Enables Cutaneous Tumor Photothermo-Chemo Therapy and Infection-Induced Wound Healing.

Traditional skin tumor surgery and chronic bacterial infection-induced wound healing/skin regeneration is still a challenge. Ideal strategy should eliminate the tumor, enhance wound healing/skin formation and antiinfection. Herein, we designed a multifunctional elastomeric poly (L-lactic acid)-poly(citrate-siloxane)-curcumin@polydopamine hybrid nanofibrous scaffold (denoted as PPCP matrix) for tumor-infection therapy and infection-induced wound healing. PPCP matrix showed intrinsically multifunctional properties including antioxidative, anti-inflammatory, photothermal, antibacterial, anticancer and angiogenesis bioactivities. The polydopamine/curcumin presented an excellent near-infrared photothermal/cancer cells toxicity capacity respectively, which enabled PPCP the synergetic skin tumor therapy and antibacterial property in vitro/in vivo. Additionally, PPCP nanofibrous matrix significantly promotes the adhesion and proliferation of normal skin cells, accelerates the cutaneous wound healing in normal mice and bacterial-infected mice through enhancing the early angiogenesis. PPCP nanofibrous matrix with multifunctional bioactivities provides a competitive strategy for the skin tumor and bacterial infection-induced wound healing.