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Endothelin‐converting enzyme‐1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones

Non‐Technical Summary  The movement of receptors to and from the surface of nerve cells determines whether nerves can detect and respond to stimulants in the extracellular fluid. It is well established that stimulated receptors move from the surface of nerves to intracellular compartments, but the processes that control movement of internalized receptors back to the surface are poorly understood. We show that an intracellular enzyme, endothelin‐converting enzyme‐1, controls the translocation of receptors back to the surface of neurones of the intestinal tract that control the normal process of digestion. This process is likely to regulate digestion, and abnormalities in the mechanism could cause digestive diseases.