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Binding of prednisolone to alpha 1-acid glycoprotein.

The binding of prednisolone to alpha 1-acid glycoprotein (AGP) was determined in vitro by equilibrium dialysis. The effects of temperature, protein concentration, and drug concentration were evaluated. The binding ratio (bound/free) correlated well with protein concentration (r = 0.958) and percent bound ranged from 2 to 12% over high to low prednisolone concentrations at physiologic AGP concentrations (100 mg/dl). Temperature changes did not perturb binding. The non-linear regression estimate of the binding constant (nk) was 4.4 x 10(3) M-1 indicative of both low affinity and low capacity of AGP for prednisolone. Overall, contribution of AGP to the total plasma binding of prednisolone is less than 3% when considered in the competitive protein binding system with transcortin and albumin. Disease induced alterations of AGP concentrations are relatively unimportant regarding plasma protein binding of prednisolone.