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[Lever positioning manipulation combined with pulsed electric field on the analgesic effect of patients with lumbar disc herniation and its influence on IL-1β and TNF-α].

OBJECTIVE
To observe the analgesic effect of lever positioning manipulation combined with pulsed electric field on patients with lumbar disc herniation and the influence on serum IL-1β and TNF-α.


METHODS
From January 2018 to March 2019, 58 patients with lumbar disc herniation were included in the study, which were randomly divided into observation group and control group by digital table method. Observation group of 29 cases, including 16 males and 13 females, aged (38.03±11.29) years old, were treated with lever positioning manipulation combined with pulsed electric field. The 29 cases in control group, including 17 males and 12 females, aged (38.21±9.16) years old, were treated with pulsed electric field. Both groups of patients were treated 3 times a week, once every other day, 3 times as a course of treatment. After 2 courses of treatment, the two groups of patients were scored before and after treatment by the numeric rating scales (NRS);at the same time, the serum levels of IL-1β and TNF-α were measured before and after treatment.


RESULTS
The NRS scores of observation group and control group were 4.21±1.76, 4.66±1.61 before treatment, and 1.28±0.84, 2.10±1.35 after treatment, respectively. The NRS scores of the observation group after treatment was significantly lower than that of the control group (P<0.05). After treatment, the concentrations of IL-1β and TNF-α in both groups became lower(P<0.05). The levels of IL-1β in observation group and control group before treatment were (119.01±69.65), (112.23±78.43) pg /ml, and after treatment were (59.78±36.60), (77.51±40.46) pg/ml, respectively. The levels of TNF-α in observation group and control group before treatment were (1.68± 1.13), (1.74±0.70) pg /ml, and after treatment were (1.14±0.56), (1.45±0.58) pg /ml, respectively. The change of IL-1β and TNF-α in observation group was better than that in control group (P<0.05).


CONCLUSION
The lever positioning manipulation combined with pulsed electric field has a good analgesic effect on patients with lumbar disc herniation, and it has a significant impact on the patient's serum IL-1β and TNF-α concentration, which can be used as a clinical guide. However, the synergistic effect of lever positioning technique combined with pulsed electric field and guidelines for clinical treatment need further research.