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PAR1, but not PAR4, regulates human platelet activation through PLD

Thrombin induces platelet activation in humans through two receptors, PAR1 and PAR4. Current anti‐platelet therapies result in excessive bleeding as a common side effect. A better understanding of thrombin regulation of platelet activation will aid in future development of anti‐platelet therapeutics with a better side effect profile. To address how thrombin regulates platelet activation, we have investigated the differential signaling pathways activated by the PARs in human platelets. Our findings establish a unique role for PAR1 and PAR4 in thrombin‐mediated platelet activation.