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Psoriasis: Evolving treatment for a complex disease

The cutaneous manifestations of psoriasis can vary in morphology and severity, and therapy should be tailored accordingly. Biologic agents are important new options for treating patients with the most severe forms of the disease. All physicians should be aware that severe psoriasis may increase cardiovascular morbidity and the risk of death, and preventive strategies for patients with severe disease should be considered. Although topical steroids and phototherapy are mainstays of treatment, biologic agents give new hope to patients with severe disease.