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The isthmic oviduct of the ewe: what is the biological significance of high affinity cytosol receptors for estradiol and progesterone?

By 36 h after estradiol (E2) injection, the level of cytosol receptors for Eand progesterone (P) in whole ,sthmic oviduct of the ewe was respectively 67 and 50% higher than in control animals. The effect of C2 and P alone and in various combinations on protein synthesis and mean cell content of RNA in this tissue was also measured. E1 stimulated both parameters whereas P alone or in combination with E2 was without real effect. The relative roles of the two receptor proteins in the isthmic oviduct of the ewe are discussed.