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Cellular kinetics of 19S and 7S hemolysin production in mice under the influence of bacterial endotoxins.

The influence of bacterial endotoxins on the cellular kinetics of 19S and 7S hemolysin production was studied in mice. The following results were obtained: As compared to the primary immunization of mice with sheep red blood cells, the additional injection of endotoxin caused a significant increase of the spleen weight and an accelerated and prolonged multiplication of 19S and 7S hemolysin-forming spleen cells. Accordingly, 7S hemolysin titers were higher and persisted for a longer period of time. In mice treated with endotoxin only, a moderate elevation of the numbers of pre-existing 19S hemolysin-forming spleen cells was detectable, whereas 7S producers could not be found.