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Inhalation of 2,3,5-triiodobenzoic acid by normal and sulfur dioxide-exposed rats.

Abstract: Exposure to 125 I-labeled 2,3,5-triiodobenzoic acid resulted in deposition of the material in the lungs of rats. The initial uptake was 20.85% followed by removal at an exponential rate. The residency half-life in the lungs was 17.7 min. Exposure of animals to sulfur dioxide for 4 consecutive days, 4 hr/day, prior to inhalation of the labeled compound did not provide statistically significant differences in the parameters studied.