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Measurement of porto‐systemic shunting in mice by novel three‐dimensional micro‐single photon emission computed tomography imaging enabling longitudinal follow‐up

Background and aims: The reference method for diagnosing porto‐systemic shunting (PSS) in experimental portal hypertension involves measuring 51Chrome (51Cr)‐labelled microspheres. Unfortunately, this technique necessitates the sacrifice of animals. Alternatively, 99mtechnetium‐macroaggregated albumin (99mTc‐MAA) has been used; however, planar scintigraphy imaging techniques are not quantitatively accurate and adequate spatial information is not attained. Here, we describe a reliable, minimally invasive and rapid in vivo imaging technique, using three‐dimensional single photon emission computed tomography (3D SPECT) modus, that allows more accurate quantification, serial measurements and spatial discrimination.