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Laparoscopic Cholecystectomy Intervention in Rats with Severe Acute Pancreatitis Delays Apoptosis of Myocardial Cells

In order to study the mechanism of laparoscopic cholecystectomy intervention in macrophages of rats 
 with severe acute pancreatitis to delay apoptosis of cardiac myocytes, Wistar rats were chosen and divided 
 into 3 groups. In addition, the related indices and protein expression in rats were observed at 2, 8, 16 and 
 24 h for each component and caspase-3 and bcl-2 levels in myocardium are detected to study the effect 
 of laparoscopic cholecystectomy intervention. Results indicated that there were no obvious symptoms in 
 control rats, while the rats in intervention group have the same symptoms as the experimental group. 
 White blood cells of the 3 groups of rats, when compared it was found that the white blood cells in the 
 experimental group decrease, followed by the intervention group but there is no significant change in the 
 control group. Morphological examination of myocardial tissue from the 3 groups of rats indicated that 
 there was no significant change in myocardial cells in the control group, while piles of blood cells were 
 found between myocardial cells in the experimental group with obvious nuclear deformation. There were 
 patches of blood between myocardial cells in the intervention group, without any significant changes in 
 nucleus. Among the changes in the content of tumour necrosis factor-α and apoptosis of myocardial tissue, 
 it is found that the tumour necrosis factor-α content and apoptotic phenomena were most significant in the 
 experimental group and there was a significant correlation between the experimental group and the control 
 group. After laparoscopic cholecystectomy, it was found that the content of tumour necrosis factor-α in 
 myocardial tissue decreased and apoptotic phenomena were alleviated, which was significantly different 
 from the experimental group (p<0.01). Western blot results indicated that expression of caspase-3 and 
 bcl-2 in myocardial tissue were the highest in the experimental group, followed by the intervention group 
 and the lowest in the control group. It was also found that the change of tumour necrosis factor-α was 
 synchronous and positively correlated with the change of apoptotic index of myocardial cells. Therefore, 
 it could be concluded that laparoscopic cholecystectomy could be used to intervene in severe acute 
 pancreatitis to delay the apoptosis of myocardial cells in rats.