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Magnetic Microparticles@UiO-67 Core-Shell Composites as a Novel Stationary Phase for High Performance Liquid Chromatography

Metal-organic framework UiO-67 was explored as a novel stationary phase for high performance liquid chromatography (HPLC). UiO-67 was, for the first time, homogeneously coated on carboxyl functionalized magnetic silica microparticles at low temperature (45 °C) by using a recently introduced liquid phase epitaxy (LPE) process. HPLC runs using the synthesized core-shell microparticles as stationary phase showed baseline separation for three phenol derivatives, applying gradient elution using acetonitrile and water as mobile phase. It also showed that UiO-67 has the largest affinity for 2,6-dichlorophenol among the phenol derivatives tested. The comparison of core-shell microparticles with 20 and 55 layers, respectively, of UiO-67 grown on the magnetic silica core proof that the UiO-67 shell determines separation behavior. Therefore, the use of UiO-67 core-shell microparticles as a stationary phase combines the advantages of a thin, homogenous MOF shell showing fast kinetics and good separation efficiency with the advantages of spherical silica microparticle cores offering high mechanical robustness and moderate pressure drop.