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[Expressions of Th, DC, NK cells in cervical tissue and the relationship with immune functions].

OBJECTIVE
To investigate the different immune functions in normal cervix, CIN and cervical cancer tissue and the relationship between HPV infection and local cervical immune functions.


METHODS
The morphology, quantity, distribution and optical density of CD4+ Th cells, S-100 dendritic cells and CD57+ NK cells in normal cervical tissue, CIN cervical tissue and cervical cancer tissue were determined by immunohistochemistry and imaging analysis.


RESULTS
In the precancerous lesions, the numbers of the CD4+ Th cells, S-100+ DC and CD57+ NK cells increased with the disease progression in CIN (P < 0.05). But, after carcinogenesis, the immune cells decreased in local cervix tissue (P < 0.05).


CONCLUSION
The local tissue of human cervical precancerous lesions had more heightened immune functions as compared with the cancer tissue.