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The Effect of βAminopropionitrile (BAPN) on Bone Mineralization 1

Summary The process or bone mineralization in the tibial diaphysis, in response to treatment with a lathyrogen, βAminopropionitrile (BAPN), at a dose known to inhibit collagen crosslinking, was studied in growing rats. BAPN treatment impaired the initial rate of mineralization but not its onset. In addition, in the BAPN treated group, there was a 5% decrease in diaphyseal ash weight, a decrement estimated to be greater than expected from the decreased rate of mineralization. This suggests that the maximal level of mineral deposition was also decreased as a result of BAPN treatment.