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Neonatal squamous cell carcinoma of the lip: case report and review of the literature.

Introduction After cutaneous malignancy, squamous cell carcinoma (SCC) is the most common malignant tumor of the head and neck. It is typically encountered in white men older than 40 years of age; only 4% of cases arise in patients younger than age 40 years. Most importantly, to our knowledge, primary SCC of the head and neck has never been described in a neonatal patient. In this report, we describe a newborn who presented with SCC of the lower lip that was detected on neonatal examination. Challenges in histopathologic diagnosis are discussed, and a review of the pediatric cases of oral SCC is also presented.