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A latex agglutination test for hepatitis type B antigen.

A new latex agglutination test system (ANTIGEX-TM) for the detection of Hepatitis B Antigen (HBAg) is described. It can be used to detect HBAg in either serum or plasma with a sensitivity comparable to that of complement fixation and about four times greater than counterimmunoelectrophoresis. The sensitivity and specificity of the system is illustrated by the test results obtained on the F.D.A. Bureau of Biologics Sera Panel No. 2 and on sera and plasma specimens from normal blood donors in the U.K. and the USA. Further applications of the technique, in the detection of HBAg in finger-prick blood samples, and in the rapid determination of antigen subtype ('ad' or 'ay'), are also described.