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Immediate and late phase allergic cutaneous reactions are not inducers of unspecific or specific local hyperreactivity

The present study evaluates the possibility of allergen‐induced unspecific and specific dermal hyperreactivity with special reference to the presence of late cutaneous reactions and allergen‐induced nasal hyperreactivity. Twenty‐six patients with strictly seasonal allergic rhinitis participated. All had a positive skin prick test for birch (Betula verrucosa) and/or timothy (Phleum pretense). Ten patients had previously displayed an allergen‐induced nasal hyperreactivity and six patients a late cutaneous reaction. An initial skin prick test with a relevant pollen allergen was done in triplicate. The immediate skin reactions were recorded after 15 min and any late‐phase reaction after 6 h. Twenty‐four hours later the patients were retested. The same pollen allergen was sited in the first flare reaction from the previous day. A histamine prick test was sited in the weal as well as in the third reaction from day 1. A histamine control was also performed in a previously unaffected area. The allergen‐induced weal reactions decreased significantly at re‐challenge compared with the results from the previous day (P < 0.05). The histamine tests resulted in similar skin reactions regardless of whether or not they were done on a previous allergen test site. This was true for both specific and unspecific reactions when the subgroups of patients with previously demonstrated allergen‐induced nasal hyperreactivity or late‐phase skin reactions were evaluated separately. These results indicate that allergen‐induced hyperreactivity is not a general feature of allergic inflammation but is a phenomenon restricted to specific sites, such as the airway mucosa.