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An experimental model of mitochondrial myopathy: Germanium‐induced myopathy and coenzyme Q10 administration

In skeletal muscles from rats treated with germanium for 23 weeks, there were numerous ragged‐red fibers and cytochrome‐c oxidase (COX)‐deficient fibers. Biochemically, germanium reduced the enzyme activities in the mitochondrial respiratory chain. Rotenone‐sensitive NADH–cytochrome‐c reductase as well as COX activities were markedly reduced, while succinate–cytochrome‐c reductase was less severely, but significantly, affected. The histopathological findings in these muslces were similar to those seen in patients with mitochondrial encephalomyopathy, suggesting that germanium‐induced myopathy may be a useful experimental model. Coenzyme Q10 administration appeared to be ineffective in preventing this experimental myopathy. © 1992 John Wiley & Sons, Inc.