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Evaluation of regional perfusion and ventilation using xenon 133 and the scintillation camera.

Experimental models of a pulmonary embolus, bronchial obstruction and embolus combined with bronchial obstruction were made in anesthetized dogs. Rapid serial images obtained with a scintillation camera allow visual estimation of regional perfusion and ventilation by recording the distribution of intravenously injected xenon 133 during suspended respiration and washout.Pulmonary embolism is not accompanied by significant regional air trapping.Bronchial occlusion shows an accompanying perfusion abnormality, and marked xenon 133 trapping.Pulmonary artery occlusion with bronchial obstruction shows absence of xenon 133 activity and no entry of xenon 133 into the lung via systemic circulation.Brief case reports show how these data can be usefully applied to clinical problems of hypoxemia in guiding diagnostic and therapeutic decisions.