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Gene scene: earlier, eventually more specific, prenatal genetic diagnosis in realm of possibility.

A NEW genetic technique that can amplify the DNA of a single cell has flung open the window of opportunity for prenatal genetic diagnosis to just 3 days after conception, and even to the unfertilized egg. In vitro fertilization (IVF) specialists at the Institute of Obstetrics and Gynecology at London's Postgraduate Medical School, Hammersmith Hospital, have determined the sex of human embryos at the eight-cell stage of development from five couples at risk for X chromosome—linked diseases. The female embryos, which do not risk inheriting the disease, were then successfully implanted in the uterus and carried to full term. Calling the implantation success rate "staggering," Alan Handyside, PhD, senior lecturer at the institute's Department of Reproduction, reports that three of the five women became pregnant with the "biopsied" embryos, two with twins and the third with a singleton. All three gave birth to unaffected daughters, although one baby died of