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Hand hygiene is crucial to combat Clostridium difficile.

Patients with Clostridium difficile infection (CDI) can contaminate the environment with spores that are able to survive for months. A previous room occupant with CDI is a significant risk factor for developing the infection. Room cleaning with commonly used disinfectants will not kill spores. Sodium hypochlorite and hydrogen peroxide are effective but correct concentration and contact time are important. Hand hygiene is a crucial element in preventing infection. In the UK, there is a clear recommendation for handwashing, rather than alcohol-based hand rub, when caring for patients with CDI.