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The Role of Folate and MTHFR Polymorphisms in the Treatment of Depression.

Major depressive disorder is most commonly treated with a combination of medication and psychotherapy. For those people that do not benefit from the standard therapy or prefer non-pharmacologic therapy, folate supplementation may be an option. Folate is normally acquired through the diet and folate deficiency is associated with depression. In the brain, folate is one nutrient among others involved in the production of the neurotransmitters that affect mood. Studies involving folate supplementation for the treatment of depression have had mixed results but have omitted to take into account the genetic polymorphisms, such as the ones in methyltetrahydrofolate reductase (MTHFR), that affect folate metabolism. Supplementation with L-methylfolate may overcome the folate metabolism problems seen in individuals with disadvantageous genetic polymorphisms.