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Electrochemical Determination of Rivastigmine Hydrogen Tartrate at β-Cyclodextrin/Multi-Walled Carbon Nanotubes Modified Electrode



Electrochemical techniques can easily be adopted to solve many problems of
pharmaceutical interest. The implementation of electroanalytical methods in the assay of pharmaceutical
formulations has increased greatly. Nowadays, owing to the critical importance of electron transfer
and surface properties, chemically modified electrodes have been employed in electrochemical sensors.
The chemically modified electrode is one of the most popular electroanalytical sensors and used in several
applications.


 In this work, a β-cyclodextrine/multi-walled carbon nanotubes (β-CD/MWCNTs) composite
modified glassy carbon electrode (GCE) was produced and applied to the detection of Rivastigmine hydrogen
tartrate (RVT) in pharmaceutical formulations. The voltammetric feature of RVT at this β-
CD/MWCNTs modified electrode was evaluated using cyclic voltammetry and square wave voltammetry.


 The β-cyclodextrin and multi-walled carbon nanotubes modified glassy carbon electrode displayed
good electrocatalytic activity in the oxidation of rivastigmine hydrogen tartrate with relatively
high sensitivity, stability and lifetime. The calibration graph of the analyte was linear over the range 10-
1500 µM with two linear segments and the detection limit was obtained as 2.0 µM (S/N=3). The results
showed that the electrochemical sensor has good sensitivity and selectivity.


 The β-CD/MWCNTs modified electrode displayed a high electrochemical activity and
good sensitivity toward the oxidation of RVT. Compared with the bare MWCNTs coated sensor, the
response of analyte increased soundly and the response potential of target analyte shifted negatively.
The results indicated that the β-CD/MWCNTs film coated electrode had good catalysis to the voltammetric
oxidation of RVT. The prepared sensor was applied to determine RVT in pharmaceutical samples
with satisfactory yields. The outcomes indicate that β-CD/MWCNTs coated electrode is a safe
choice for the detection of RVT.