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[Ultrastructure of anterior lobe epithelium of the prostate of rat. I. Initial changes in epithelial cells following administration of estrogen (author's transl)].


 The ultrastructure of the epithelial cells of anterior prostatic lobe of normal rats as well as initial changes of the epithelium associated with estrogen dosing were investigated. The cells were noted to possess remarkably well-developed rough endoplasmic reticulum and pre sent regularly altering features of physiologic function characterized by differences in electron density. The cytoplasmic secretory granules in the upper pole region were distinguishable into 2 types, the highly electron-opaque fine granules and those that were moderately electron-dense with a homogenous structure. Electron microscopic findings corresponding to the passive microapocrine mechanism by the classification of Kurozumi were obtained. Estrogen administration caused regressive changes in the epithelial cells of the prostate, characterized primarily by cytomembranolytic figures. The findings indicated a state preparatory for restoration in cellular function associated with membrane metabolism and seem to indicate influence of the hormone on the cell in toto.
