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Efficacy of I-scan Endoscopy in the Diagnosis of Gastroesophageal Reflux Disease with Minimal Change

Background/Aims The aim of the study was to evaluate the efficacy of i-scans for the diagnosis of gastroesophageal reflux disease, especially where only minimal change is involved. Methods The esophageal mucosa was inspected using an i-scan following conventional white light endoscopy. The examination with iscan was performed under tone enhancement (TE) esophagus (e) mode. Patients with subtle distal esophageal mucosal changes without definite mucosal breaks, such as blurring of Z-line (B), mucosal coarseness (C), hyperemic or purplish discoloration (D), erythema (E), ectopic gastric mucosal islet (I) and mixed type were classified as minimal change. Results A total of 156 patients were included. Using i-scan endoscopy, the number of minimal change was found to further increase from 94 (conventional endoscopy; 19B, 9C, 29D, 13E, 5I, 19 mixed type) to 109 (i-scan; 15B, 8C, 29D, 16E, 5I, 36 mixed type). And 14 patients who had single type by conventional endoscopy were converted to mixed type after i-scan. Therefore, 29 of 156 patients were upgraded after i-scan, they were account for 19% (p<0.0001; 95% confidence interval, 0.13 to 0.25). Conclusions The use of i-scan endoscopy significantly improves the identification of minimal change and helps to identify more precisely the type of minimal change.


INTRODUCTION
Dong-A University Medical Center for medical checkup or regular follow up, or for symptoms of heartburn and acid regurgitation suggesting GERD. Patients with upper gastrointestinal structural disease such as peptic ulcer or tumor, or systemic disease affecting esophageal motility were excluded from the study. Subjects' information was analyzed retrospectively based on their medical records.

Methods
In each study patient, the gastroesophageal junction was first inspected using standard white light endoscopy alone without i-scan. And then, the i-scan mode was activated by pressing the appropriate button at the endoscope control head and the gastroesophageal junction was re-inspected. The examination with i-scan was performed under tone enhancement (TE) esophagus (e) mode, which were able to characterize the details of the gastroesophageal junction. All endoscopic examination was performed by two expert endoscopists with more than 1,000 cases of experience, who were highly familiar with Pentax i-scan.
Patients with mucosal breaks identified by endoscopy were classified as erosive esophagitis based on the Los Angeles (LA) classification (grade A, one or more mucosal breaks no longer than 5 mm, not bridging the tops of mucosal folds; grade B, one or more mucosal breaks longer than 5 mm not bridging the tops of mucosal folds; grade C, one or more mucosal breaks bridging the tops of mucosal folds involving <75% of the circumference are; grade D, one or more mucosal breaks bridging the tops of mucosal folds involving >75% of the circumference). 12 Patients with no visible mucosal break on endoscopy were classified as non-erosive reflux disease (NERD). Of NERD patients, patients with subtle distal esophageal mucosal changes, such as blurring of Z-line (B), mucosal coarseness (C), hyperemic or purplish discoloration (D), erythema (E), ectopic gastric mucosal islet (I), and mixed type were classified as minimal change. 13,14

Statistical analysis
All data are given as mean±standard deviation. Weighted kappa value and χ 2 test were performed in order to assess the influence of the use of the i-scan compared with conventional endoscopy on the number of detected lesion. According to statistical conventions, the confidence level for this test was chosen as alpha=5%. The interobserver agreements for the i-scan findings between investigators were determined using kappa statistics. The strength of interobserver agreement was categorized according to the following definitions: 0.0-0.20, slight; 0.21-0.40, fair; 0.41-0.60, moderate; 0.61-0.80, good; 0.81-1.00, almost perfect. A p-value was considered significant if it was <0.05. The statistical software program (SAS, version 9.1; SAS Institute Inc., Cary, NC, USA) was used for all data analysis. Colon cancer, liver cirrhosis, stroke, chronic renal failure; b) Teperone (Selbex ® ), Benexate betadex (Ulgut ® ), Ecabet sodium (Gastrex ® ).

RESULTS
A total of 156 patients with mean age of 57.5±13.4 years were included in the study. The male was 85 patients, the female was 71 patients. A total of 96 (62%) patients had typical gastroesophageal reflux symptoms. One hundred three were inpatients, 53 were outpatients. One hundred sixteen patients had underlying medical diseases and 53 patients had medication history (Table 1).

A B
nology, which is also called virtual chromoendoscopy or endoscopic Photoshop ® . Through the application of cutting edge computer-based enhancement filters, dynamic multiple modes reveal the hidden colors, vascularity, pit patterns, topography and architecture of possible problematic tissue, all at the mere touch of a button. This consists of three types of algorithms: surface enhancement (SE), contrast enhancement (CE), and tone enhancement (TE). SE enhances light-dark contrast by obtaining luminance intensity data for each pixel and applying an algorithm that allows detailed observation of a mucosal surface structure. CE digitally adds blue color in relatively dark areas, by obtaining luminance intensity data for each pixel and applying an algorithm that allows detailed observation of subtle irregularities around the surface. Lastly, tone enhancement makes color tone and structure more evident, which may be used to assess the necessity of more detailed test by means of dye spraying, magnified observation, or biopsy. TE is classified into 6 modes, which are TE pattern (p), TE vessel (v), TE barrett (b), TE esophagus (e), TE gastric (g), and TE colon (c). TE esophagus (e) mode was used for this study. This mode emphasizes relatively dark red color and white part of the mucosa in the image by digitally fading the red color, which makes it suitable for esophagus by emphasizing the vessel structure and the subtle mucosal color changes. For this reason, we can assume that 'erythema (E)' subtype would be commonly detected under TE esophagus (e) mode. In result, among additionally detected 29 patients, 15 patients were demonstrated erythema (E) subtype. About 60% patients with GERD reveal no visible abnormality on conventional endoscopy, so it is difficult to diagnose GERD under the standard white light endoscopy. 15 Various studies on evolved endoscopic techniques to improve the detection rate of GERD are published in the recent few years, one of which reported that NBI (Olympus Co., Tokyo, Japan) might be more effective for detecting NERD than conventional endoscopy. Sharma et al. 10 demonstrated that reflux esophagitis group had significantly more intraepithelial papillary loops, dilatation, tortuosity, microerosion and vascularity of squamocolumnar junction than control group. In 2009, Hoffman et al. 11 reported that chromoendoscopy with Lugol's solution in conjunction with HD endoscopy significantly improved the detection rate of erosive reflux disease, and i-scan endoscopy also was able to detect indistinct blood vessels and mucous structures clearly.
Despite the promising results of previous studies, there was no report to improve the detection rate of GERD especially where only minimal change is involved. Minimal change is a significant clinical problem as it is difficult to diagnose but nevertheless need adequate therapy. This study found that detection rate of minimal changes was significantly increased by 19% using iscan. Furthermore, in NERD patient with typical gastroesophageal reflux symptoms, 9.6% patients was more precisely diagnosed by i-scan. There is a considerable discrepancy between endoscopic abilities to detect even minute lesions and their clinical relevance. But, i-scan endoscopy showed good interobserver agreement with kappa value of 0.84 (95% CI, 0.77 to 0.92).
In summary, i-scan endoscopy is simple and useful for diagnosis of minimal change with GERD. I-scan could be appealing for the endoscopist, because it is easy, safer, rapid and more accurate method for a detection of the minimal change with GERD. And it may also assist in a rational use of proton pump inhibitor therapy and facilitate the assessment of response to antireflux therapies. However, i-scan leads to visibility of new mucosal detail that is of little clinical relevance and has to be evaluated in further studies.

Conflicts of Interest
The authors have no financial conflicts of interest.