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Toxicity Studies of Ionic Liquids and Heavy Metal Compounds to MCF-7 and Photobacteria Q67

The inhibition toxicities of four ionic liquids and four heavy metal compounds to MCF-7 human breast cancer cells (MCF-7) and Vibrio qinghaiensis sp.-Q67 (Q67) were determined using MTS assay and microplate toxicity analysis, respectively. The resulting concentration-response data was modeled by using sigmoidal models (Weibull and Logit). Results showed that all concentration -response relationships could be effectively described by the Weibull or Logit function. The toxicities of ILs to both MCF-7 and Q67 have the alkyl chain effect character. However, the toxicity order of four heavy metal compounds to MCF-7 and Q67 were different. Compared with Q67, MCF-7 is more sensitive to heavy metal compounds and less sensitive to ILs