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Seroprevalence of hepatitis E in Nahavand, Islamic Republic of Iran: a population-based study.

A 2-month community-based survey in February/March of 2003 was carried out to study the seroprevalence of hepatitis E virus (HEV) infection in Nahavand, Islamic Republic of Iran. From each of 6 urban regions of Nahavand, 304 inhabitants > or = 6 years were recruited through systematic random sampling (total 1824). Participants were tested for anti-HEV IgG using ELISA. The overall seroprevalence of HEV was 9.3% (95% CI: 8.2%-10.9%). Based on multivariate adjustment, only sex (OR = 1.61, 95% CI: 1.13-2.28) and age (OR = 1.03, 95% CI: 1.01-1.04) emerged as significant risk factors. This intermediate prevalence urges further investigations on HEV infection in the Islamic Republic of Iran.