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Thiazolopyrimidines: A Retrospective Study of Synthesis,
Structure-Activity Relationship and Diverse Pharmacological Actions

Thiazolopyrimidine is a nitrogen and sulphur containing heterocyclic aromatic molecule. The bicyclic compound is made by fusing two
aromatic rings, thiazole and pyrimidine and replacing one carbon atom with nitrogen and sulphur. The current present work covers a wide
range of methods for synthesizing thiazolopyrimidine and its derivatives using a variety of catalysts, solvent medium and microwave
irradiation with a goal of achieving a high yield and rapid separation of the product. This article describes the evolution of thiazolopyrimidine
as antimicrobial, antiviral, anti-Parkinson, anticancer, anti-inflammatory as well as its structure-activity relationship and potential mode
of action for future research. It also includes a list of current patents filed/granted linked to various pharmacological activities in the
previous few years.