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Studies on a gross‐virus‐induced lymphoma in the rat. II. The role of cell‐membrane‐associated and serum p30 antigen in the antibody and cell‐mediated response

The internal viral protein, p301, has been identified by cytotoxicity tests using xenogeneic sera, on MuLV‐G‐induced rat lymphoma cells. In this system internal virion antigens, and in particular p30, are cytotoxic target antigens for syngeneic antibody and cell‐mediated cytotoxicity; p30 is also present in the serum of rats with progressively growing lymphomas, and is the principal antigen responsible for the inhibition of cell‐mediated cytotoxicity produced by these sera.