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773: FEVER BURDEN AND HEALTH-RELATED QUALITY OF LIFE AFTER INTRACEREBRAL HEMORRHAGE

Critical Care Medicine • Volume 46 • Number 1 (Supplement) www.ccmjournal.org Learning Objectives: Fever is associated with worse functional outcomes after intracerebral hemorrhage (ICH), however, there are few prospective data to quantify the relationship with health related quality of life (HRQoL). We tested the hypothesis that increased burden of fever is independently associated with decreased HRQoL at follow-up. Methods: We prospectively enrolled patients with spontaneous ICH admitted to a tertiary hospital between 2011 and 2015. We recorded the highest core temperature each calendar day for 14 days after ICH onset. Fever burden was defined as the number of days with a fever ≥ 100.4o F. HRQoL outcomes were measured with Neuro-QoL domains of Cognitive Function and Mobility at 28 days, 3 months, and 1 year, with T-scores normalized to the general US population at 50 ± 10. Results were analyzed using mixed effects regression analysis. Results: One hundred and six patients met the requisite criteria with a total of 162 follow-ups. The mean age was 62.2 ± 14.3 years and 47% were female. The incidence of fever was 39.6%, median fever burden was 3 [1–6] days. The population had relatively mild ICH severity, with a median NIHSS score of 7 [2–13] on admission and median hematoma volume of 7 [2–20]mL. Each day with a fever was independently associated with lower Mobility HRQoL (T-score -0.9,[-1.6 to -0.2]; p = 0.01) and Cognitive Function HRQoL (t-score -1.3 [-2.0 to -0.6];p = 0.001) after correction for National Institute of Health Stroke Scale score on admission, age, and time to follow-up. Conclusions: Each additional day with a fever was predictive of worse HRQoL in the domains of Cognitive Function and Mobility after ICH up to 1 year. Effective fever control in ICH patients may improve cognition and mobility outcomes. HRQoL outcomes may be a sensitive and powerful way to measure the efficacy of fever control in future research.