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Morphologic features of the lungs of aging beagle dogs.

Lungs of 20 Beagle dogs 289 to 3,649 days of age were examined histologically. The primary lesion noted in older dogs was large accumulations of pulmonary macrophages containing dust and golden-brown pigment in the walls of the respiratory bronchioles and at the mouths of the alveoli. These lesions increased in size with increasing age. Focal pneumonitis was often associated with macrophage accumulations. As dogs aged, there was an increase in the area of each lung section occupied by alveolar ducts. Older dogs had larger bronchial glands and increasing calcification of bronchial cartilage.