{'fraction_non_alphanumeric': 0.021132713440405747, 'fraction_numerical': 0.0016906170752324597, 'mean_word_length': 5.923976608187134, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Editorial: simultaneous prolonged monitoring of the acid pocket and oesophageal reflux

control, and synergistic interactions between adrenergic and opioid agents, for example, may increase their respective effects.5 Centrally mediated effects, such as those driving nausea (a common side effect of SNRIs)6 or relating to pain states, could also be implicated in the manometric associations seen in this study. In any case, more research to evaluate the potential links between these commonly prescribed medications and oesophageal physiology is warranted. Finally, as Drs Ravi and Katzka have elegantly shown in their research with opioids, prescribed medications can have a significant, clinically relevant effect on manometric diagnoses. Aggressive interventions such as dilations or botulinum toxin injections for presumed motility disorders such as oesophagogastric junction outlet obstruction, which may be medication side effects, need to be avoided. In that regard, evaluation of patients’ medication profiles at manometry (particularly when abnormalities are seen) is highly recommended, as the cessation of culprit medications may obviate the need for further intervention.