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P04.26: Maternal diabetes and hypertrophic cardiomyopathy in the fetus

Objective: Fetuses with problems, for example growth restriction, diabetic mothers or complex heart disease may change the hemodynamics of ventricular chambers come to alter chamber size, shape, contractility, filling properties, stroke volume (SV,mL) and ejection fraction (EF,%). However normal ranges have been varied, the purpose of this study is to report the mean ranges of cross-sectional and M-mode echocardiographic measurements and to compare with each methods. Methods: This was a prospective study of 62 normal fetuses (Gestational age 20 ∼ 38 weeks) referred for a routine sonographic examination. Two operators using a 2 ∼ 6 MHZ sector probe (Accuvix XQ,MEDISON,co.,LTD.Korea) performed all measurements. The cross-sectional formula employed was the method of discs, which divides the ventricles into 20 equal-thickness discs. (Simpson method). The other method was Teichholz formula. All volumetric data by M-mode echocardiography were computed. Results: We collected normal ranges for the left and right enddiastolic ventricular dimension (EDD) and ejection fraction. M-mode measurements: The mean LVEDD was 9.1 ± 0.45 mm, LV SV 1.09 ± 0.92 mL, LV EF 63.38 ± 16.07%, RVEDD 1.08 ± 1.67 mm and RV EF 60.42 ± 19.12%. Simpson method measured the LV EF was 56.62 ± 17.67%, RV EF was 58.51 ± 19.55%. As gestational age, there was no significant difference between M mode and crosssectional echocardiography. Also there was not a difference of the ventricular function which it follow gestational age. Conclusion: This is the initial research which shows ranges for fetal ventricular ejection fraction and quantify them in fetus by the noninvasive echocardiography. In the future, we apply this method in the fetuses who have a problem and reveal an interrelation between prenatal and postnatal ventricular function. It will be helpful to decide a treatment time and predict their prognosis.