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SERCA2 activity is involved in the CNP‐mediated functional responses in failing rat myocardium

Myocardial C‐type natriuretic peptide (CNP) levels are increased in heart failure. CNP can induce negative inotropic (NIR) and positive lusitropic responses (LR) in normal hearts, but its effects in failing hearts are not known. We studied the mechanism of CNP‐induced NIR and LR in failing hearts and determined whether sarcoplasmatic reticulum Ca2+ ATPase2 (SERCA2) activity is essential for these responses.