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"Lymphoepithelioma-like" thymic carcinoma: another tumor related to Epstein-Barr virus?

The key role of the thymus gland in the establishment and maintenance of cell-mediated immune responses has been known since the pioneering work of Martinez et al.1 and Miller2 in the early 1960s. This function is carried out through a close interaction between bone marrow–derived lymphoid cells and endodermally derived epithelial cells — a feature that was already apparent to anatomists on purely morphologic grounds and that had led to the designation of the thymus as a "lymphoepithelial" organ and to the interplay of its two main cell constituents as "lymphoepithelial symbiosis." A morphologic analogy along these lines can be . . .