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A KINETIC ANALYSIS OF DRUG RELEASE FROM AQUEOUS SOLUTIONS OF POLYSORBATES 20 AND 80

Interactions between solubilizates and aqueous solutions of non-ionic surfactants have been characterized previously using techniques such as solubility Fleasurement and equilibrium dialysis. utilized in such investigations probably due to difficulties in the analysis of the data. This report describes an attempt to characterize the interactions between salicylic acid and polysorbate solutions using a dynamic dialysis system and a statistical treatment of data based upon compartmental analysis.