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Decrease in cholera toxin-binding T cells in aged mice and human volunteers.

The capacity of T cell-enriched populations of cells from mice and human volunteers to bind cholera toxin was analyzed by means of a fluorescence-activated cell sorter. In aged mice and humans, the number of cells capable of binding high concentrations of cholera toxin was lower than that in young mice and humans. The capacity to bind cholera toxin may be one of the useful indicators for the detection of aging in the immune system.