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New AAN Guidelines on Trigeminal Neuralgia Released on Aug. 20

Investigators at Boston’s Children’s Hospital and international collaborators identified a halfdozen mutated genes in autistic people in Middle Eastern families. The implicated genes have diverse roles, yet all seem to mediate activation of neuronal genes, they reported in the July 11 Science. The researchers say the findings support some current approaches to autism that may activate and maintain connections among nerve cells. More specific therapy for the disorder may one day be possible, they suggest, because the different genes affected in these families are not deleted but still present, even though they are not working properly. “It tells us the problem involves gene regulation,” said Seung-Yun Yoo, PhD, one of the investigators who was a postdoctoral fellow funded by the National Alliance for Autism Research (currently Cure Autism Now) in the laboratory of Christopher A. Walsh, MD, PhD, at Children’s Hospital. “It’s not that they lack these genes,” Dr. Yoo said, “but expression may be dysregulated during neural activity.” Ase izure-re la ted death at an epilepsy monitoring unit (EMU) in Colorado is raising the question: Should EMUs implement stricter safety policies? Last October, a 64-yearold man with epilepsy died after having a seizure and suffocating in his pillow, Mark C. Spitz, MD, director of the Epilepsy Center at the University of Colorado Hospital (UCH) in Denver, told Neurology Today in a telephone interview. The man was left unobserved for 65 minutes while the electrographic technologist monitoring the EMU attended to other responsibilities, said Steven P. Ringel, MD, professor and director of the neuromuscular division at the University of ColoradoDenver in Aurora. Dr. Ringel is also the vice president for safety outcomes at the UCH and associate editor in chief of Neurology Today. The patient death prompted the UCH to change its policies to ensure patients are monitored at all times. Now, two technicians are required to be on duty in the eight-bed EMU so at least one of them will be watching the patients through video monitors at all times, Dr. Ringel said. Death in Epilepsy Monitoring Unit Raises Questions about Safety Policies and Practice Standards