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A0456 Risk of New-Onset Atrial Fibrillation among Heart, Kidney and Liver Transplant Recipients: Insights from a National Cohort Study

Objectives: To explore the incidence of atrial fibrillation (AF) in various populations of patients with organ transplantation (OT). Methods: We use a large national data set from Taiwan to investigate the incidence of AF after OT. Frequency matching method was used to match controls: OT patients 4:1. Kaplan-Meier analyses with the use of the Aalen-Johansen estimator was employed for estimating the cumulative incidences of new-onset AF. The Fine-Gray competing risks model was also performed to analyze the risk of AF for the OT cohort compared with the non-OT cohort. Results: 6955 OT patients and 27820 controls were included in this study. OT did lead to a 3.92-fold risk for AF (95% confidence interval (CI) = 2.07–4.62], especially in the subgroup of female gender [adjusted subhazard ratio (aSHR) = 6.66, 95% CI = 3.85–11.5], age ⩽ 49 years (aSHR = 8.19, 95% CI = 3.99–16.8) and without comorbidity (aSHR = 4.61, 95% CI = 2.71–7.87). Moreover, liver recipients tend to be more likely to develop new-onset AF among those OT patients (aSHR = 4.07, 95% CI = 2.63–6.30) as compared to the controls. Conclusion: OT patients have a higher risk for AF. The association identified in this study might alert and provide clinicians for becoming more sensitive to the AF risk among organ recipients, especially those received liver transplantation.