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Regenerative rehabilitation in injuries of cartilaginous tissue (review)

SummaryThe review article is devoted to the analysis of the cur-rent state of regenerative and rehabilitative treatments in orthopedics, the possibilities of restoring the func-tioning of cartilaginous tissue lost due to aging, inju-ries or di seases. An overview of the main methods and approaches to enable effective regenerative and reha-bilitation measures is given. The study of the molecular genetic basis of mechanotransduction and mechano-therapy will allow to identify genes and molecules, the expression levels of which can serve as biomarkers of the effectiveness of regenerative-rehabilitation measures. These mechanisms are potential therapeutic targets for stimulating cartilage regeneration. The focus of the arti-cle is on the choice of an individual approach, both when conducting basic scien tific research and developing re-habilitation programs. All this will significantly improve patient outcomes.