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Transcriptional regulation of early T‐cell development in the thymus

T‐cell development occurs in multipotent progenitors arriving in the thymus, which provides a highly specialized microenvironment. Specification and sequential commitment processes to T cells begin in early thymic progenitors upon receiving thymus‐specific environmental cues, resulting in the activation of the genetically programmed transcriptional cascade that includes turning on and off numerous transcription factors in a precise manner. Thus, early thymocyte differentiation has been an excellent model system to study cell differentiation processes. This review summarizes recent advances in our knowledge on thymic T‐cell development from newly arrived multipotent T‐cell progenitors to fully committed T‐cell precursors, from the transcriptional regulation perspective.