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Single‐breath xenon polarization transfer contrast (SB‐XTC): Implementation and initial results in healthy humans

To implement and characterize a single‐breath xenon transfer contrast (SB‐XTC) method to assess the fractional diffusive gas transport F in the lung: to study the dependence of F and its uniformity as a function of lung volume; to estimate local alveolar surface area per unit gas volume SA/VGas from multiple diffusion time measurements of F; to evaluate the reproducibility of the measurements and the necessity of B1 correction in cases of centric and sequential encoding.