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Dynamic movement of cytochrome c from mitochondria into cytosol and peripheral circulation in massive hepatic cell injury

Background : In the process of apoptosis, it is known that the transition of cytochrome c from mitochondria into the cytosol occurs, and tumor necrosis factor (TNF)‐α is one of the molecules responsible for this event. But in the state of hypercytokine induced by d‐galactosamine (D‐GaIN)/Lipopolysaccharide (LPS), the localization of cytochrome c is little known.