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Getting to the heart of the matter: a trialist's approach to the use of nonsteroidal anti‑inflammatory drugs for patients with chronic pain syndromes.

In this editorial, I refer to the relative risks associated with different interventions. To provide a perspective of what it means, please consider the risks of particular events in the placebo group of controlled trials of cyclooxygenase-2 inhibitors: major vascular events (0.82%) including nonfatal myocardial infarction (MI; 0.29%) or any MI (0.33%), any stroke (0.36%), heart failure (0.26%), upper gastrointestinal (GI) bleeding (0.14%) with any major GI complication (0.19%).