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Clinical Significance of Detection of Serum LHBs in Chronic Hepatitis B

Objective To investigate the clinical significance of detection of serum hepatitis B virus large surface protein(LHBs) and HBV-DNA in patients with hepatitis B.Methods A total of 260 CHB patients were recruited in the study.Serum LHBs,Hepatitis B e antigen(HBeAg) and Pre-S1 antigen of hepatitis B virus(HBVPreS1) were measured by enzyme-liked immunosorbent assay(ELISA).Serum HBV-DNA level was quantitatively detected by real-time polymerase chain reaction(PCR).Serum ALT and AST were detected by automatic biochemical analyzer.Results All patients in the study showed high positive rate in LHBs and HBV DNA.Of the 260 patients,59.23% were found LHBs and 67.69% were found HBV-DNA.Serum LHBs was significantly higher in patients as compare to those HBV-DNA(39.61%,χ 2 = 20.010) and HBVPreS1(32.96%,χ 2 = 36.864) in patients,the difference was statistically significant(P 0.01).The difference of serum LHBs in different HBV-DNA level groups(F = 23.90) had statistically significant(P 0.01).Serum LHBs showed direct correlation with HBV-DNA level(r = 0.78,P 0.01).The LHBs positive patients' ALT,AST markers were higher than those in the HBV-LP negative patients.Conclusion LHBs showed a high coincidence rate with HBV-DNA.Monitoring serum LHBs is a good adding test for diagnosing HBV replication and active.