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No evidence for human cytomegalovirus infection in pediatric medulloblastomas.

Human cytomegalovirus (HCMV), a member of the herpes-virus family, remains present after primary infection during a patient’s entire life. The overall seroprevalence of HCMV is around 20.7% for children and adolescents, of whom 0.7% are born with a congenital HCMV infection in the United States. 1 In the last decade, several studies have suggested a role for HCMV as a driver of tumorigenesis in pediatric brain tumors (eg, medulloblastoma, 2 glioma, 3 and adult glioblastoma mul-tiforme). 4,5 Therefore, HCMV is considered to be a potentially interesting therapeutic candidate for immunotherapy against these cancers. 6 In pediatric medulloblastoma, however, there is conflicting evidence for HCMV positivity in tumor cells. Several studies show no HCMV positivity even in HCMV-seropositive patients with current standard procedures, 7,8 while others detect HCMV in the majority of tumors. 2 In the present study, we surveyed a panel of pediatric medulloblastomas for HCMV infection.A total of 26 formalin-fixed, paraffin-embedded pediatric medulloblastoma tissue samples were retrieved from the archives the Department of Pathology at the University Center Utrecht in the Netherlands. Since we are using archival pathology material, which does not interfere with patient care and does not involve of the patient, no ethical approval was required according to Dutch legislation. Each sample was independently reclassified by 2 neuropathologists (W.G.M.S. W.V.H.) the WHO . We analyzed HCMV by immunohistochemistry for immediate-early (clone E13, and late