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Primary multifocal skull vault lymphoma in an acquired immunodeficiency syndrome patient

Primary skull vault non-Hodgkin's lymphoma with extra- and intra-cranial soft tissue components in an immunocompromised patient is extremely rare. There are only four cases reported in literature till date and in none were the lesions multifocal or had a discrete intraorbital component. We report such a case of multifocal primary skull vault lymphoma successfully managed in an acquired immunodeficiency syndrome patient. Distinguishing primary bone lymphoma from other skull vault lesions is important because of different management protocols.