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Effects of bopindolol on renal function

The effect on renal function of the long-acting β-blocking agent bopindolol was assessed in five hypertensive subjects whose glomerular filtration rate was less than half the normal values. The patients were given a daily dose of 1 mg bopindolol. The renal plasma flow, glomerular filtration rate, filtered fraction and fractional excretion of sodium remained unchanged after 12 h and 21 days in three cases and after 12 h in two cases. The same observations had been made in 10 normotensive volunteers and 10 hypertensive subjects in a previous study.