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Tailored Helicobacter Pylori eradication therapy in obese patients undergoing bariatric surgery.

OBJECTIVES
to compare the efficacy and safety of a tailored quadruple concomitant therapy based on body weight with the same scheme but with fixed doses in obese patients undergoing bariatric surgery.


METHODS
this prospective study included 104 obese patients.


RESULTS
the weight-based therapy group achieved significantly higher eradication rates in the intention-to-treat analysis; 86.3% (95% CI: 74.3-93.2) vs 66.1% (95% CI: 52.6-77.3), P<0.05, Relative risk: 1.31 (95% CI: 1.05-1.63). Discontinuations and adverse events were similar in both groups.


CONCLUSIONS
A tailored quadruple concomitant therapy based on body weight seems to be more effective than the standard quadruple concomitant therapy in obese patients.