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Cytotoxic antibodies to cultured lymphoblasts unrelated to epstein‐barr virus

A micro‐51chromium‐release assay was used to examine the possible relationship between antibodies cytotoxic to lymphoid cells and EBV infections of the donors. No correlation was found between sera capable of killing lymphoid cells pre‐labelled with51 chromium and the presence or absence of antibodies to the viral capsid antigen (anti‐VCA). Sera obtained from patients with infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma and Hodgkin's disease known to have elevated titers to anti‐VCA showed cytotoxicity similar to control values. There appeared to be both heat‐stable and heat‐labile complement‐dependent cytotoxic antibodies.