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Synthesis of Bicyclic ortho-Aminocarbonitrile Derivatives Catalyzed by 1,4-Diazabicyclo[2.2.2]octane

One-pot three-component reactions catalyzed by 1,4-diazabicyclo[2.2.2]octane (DABCO) for the synthesis of bicyclic ortho -aminocarbonitrile derivatives (21 examples, 68% ～ 96%) have been developed. The reactions proceeded smoothly at room temperature and generated the corresponding products in short reaction time with high to excellent yields. Importantly, the desired products could be easily collected through simple filtration and washing with ethanol.