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5‐HT1A polymorphism and self‐transcendence in mood disorders

Recently, an association between serotonin 1A receptor binding potential and self‐transcendence scores at the temperament and character inventory (TCI) has been reported. We tested involvement of 5‐HT1A gene in this trait, in a sample of 40 remitted mood disorder patients. Subjects with the 5‐HT1A*C/C genotype showed significantly lower scores at the total self‐transcendence and at the sub‐scales of transpersonal identification and spiritual acceptance. Our preliminary results further support the involvement of the serotoninergic pattern in the self‐transcendence character trait. © 2005 Wiley‐Liss, Inc.