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New oncogenic signalling pathway: EWS‐Oct4 mediates bone and soft tissue tumourigenesis by activating fibroblast growth factor‐4

Chromosomal translocations involving the interchange of parts between two nonhomologous chromosomes can often lead to cancer by creating new fusion proteins. Here, Kim and co-workers show that a chimeric protein, Ewing's sarcoma-octamer-binding transcription factor 4, transcriptionally activates fibroblast growth factor-4 and triggers a downstream cascade of oncogenic signalling pathways, thereby facilitating the initiation of human bone and soft tissue tumour development.