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Influence of epizootic categories of birds on germ resistance

Non-plastic diseases are a problem both in medical and veterinary practice. The most common diseases in poultry caused by oncogenic viruses include lymphoid leukemia (LL) and Marek's disease (MD). A vaccine has been developed for HM. On breeds and lines of birds with high resistance to neoplasm, the vaccine is much better. It is possible to solve this problem by increasing the specific and overall resistance, by creating genetically disease-resistant lines and crosses of the bird. However, this requires some knowledge about the mechanism of disease resistance, the interaction of the pathogen with the body, ways to increase resistance, its correction, sensitivity of lines and hybrids to pathogens of the most common diseases. This requires criteria or markers that are indicators of the body's immunocompetence. The studies were performed on chickens of Leghorn D4 line and Poltava clay P37. The level of antibodies to leukemia-sarcoma complex (VLSC) viruses was determined in the neutralization reaction by a conventional method. As a viral material, a 30% suspension of tumors obtained from infected chickens with Raus sarcoma virus was used. The article presents data on the influence of epizootic categories of poultry on the resistance of embryos to oncornaviruses. For research, the bird by status with respect to antibodies to oncoviruses was divided into four categories: A+ the presence of antibodies; A- the absence of antibodies; B+ the presence of the virus; B- no virus. When selecting a resistant bird for neoplasm, only two categories A-B- and A+ B- are theoretically relevant. The possibility of obtaining offspring with or without antibodies, depending on the status of this phenomenon in his parents, was established. According to the data obtained in 60.0% of cases, the bird, free from neutralizing antibodies against HRV, can be obtained by mating cocks and chickens free of these antibodies. However, the absence of antibodies from parents cannot guarantee such in their offspring (approximately 40.0% were with antibodies). It may be that some of the offspring of the antibody-free bird do not have genetic resistance to infection and react with antibody production when in contact with the virus. If the chickens and roosters had antibodies, their offspring were only free from them in 31.3% of cases. These data, however, indicate that resistance to infection is inherited from offspring and from parents resistant to natural infection with oncoviruses, which makes it more likely to obtain resistant offspring (P < 0.01). There is also a pattern of getting families free of counteracting factors: they are more likely to get from chickens and cocks that have no antibodies. However, not always the absence of antibodies in roosters and chickens guaranteed the absence of antibodies in their offspring.