{'fraction_non_alphanumeric': 0.03051948051948052, 'fraction_numerical': 0.022727272727272728, 'mean_word_length': 4.644688644688645, 'pattern_counts': {'":': 0, '<': 1, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Impact of Urinary pH on the Efficacy of a Postoperative Single Instillation of Mitomycin-C.

OBJECTIVE
To assess the effect of the urinary pH value on the efficacy of a postoperative single instillation of mitomycin-C.


STUDY DESIGN
A descriptive study.


PLACE AND DURATION OF STUDY
Department of Urology, Ankara Numune Training and Research Hospital, Ankara, Turkey from 2011 to 2016.


METHODOLOGY
Patients newly diagnosed with low-risk non-muscle invasive bladder cancer and given a postoperative single instillation of mitomycin-C were retrospectively reviewed. The demographic data and pre-instillation urinary pH values of the patients were recorded. All patients included in the study (n=117) were followed up for five years. The primary outcome was the time to the first recurrence. The patients were divided into two groups: Group 1 consisted of 87 patients with no recurrence and Group 2 comprised 30 patients that had recurrence during the follow-up.


RESULTS
The mean pre-instillation urinary pH value was significantly lower in Group 2 than in Group 1 (5.89 vs. 5.37, p <0.001). The receiver operating characteristic analysis revealed that the cut-off value of urinary pH in predicting recurrence was 5.25. The patients with a urinary pH value of 5.25 or greater had significantly higher recurrence-free survival rates.


CONCLUSIONS
The patients with higher urinary pH before a single instillation of mitomycin-C had better recurrence-free survival.


KEY WORDS
Bladder cancer, Mitomycin-C, Single instillation, Urinary pH.