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Treatment of Ureteral Lithiasis with Tamsulosin: Literature Review and Meta-Analysis

Objective: Ninety percent of ureteral calculi <4 mm are expelled over a period of 3 months; if they are >6 mm the elimination possibilities are reduced to 30%. Presently, investigations in the treatment of ureteral lithiasis have the objective of modifying ureter contractibility with the aid of calcium antagonist and α-blocking drugs. The objective of this study is to analyze the effect of tamsulosin in the treatment of the distal ureter lithiasis and to make a systematic analysis of the literature. Patients and Methods: In a prospective study 70 cases of distal ureter lithiasis were divided into 2 groups: group 1 = 35 cases treated with ibuprofen (600 mg/12 h) and 2,000 ml water/24 h with tramadol on demand, and group 2 = 35 cases with the same treatment as described before plus tamsulosin 0.4 mg/day over 3 weeks. The number of stone-free patients, time to expulsion and the necessity for analgesia were evaluated. A literature review (2002–2007) and meta-analysis of 11 studies was performed. Statistical analysis included relative risk (RR), number needed to treat (NNT) and χ2 test. Results: Group 1 reported 19 stone expulsions (54.3%) and group 2 30 expulsions [85.7%, χ2 = 8.23 (p < 0.01), RR = 1.58, NNT = 3 (95% CI 2–9)]. The mean time to expulsion was 14 days in group 1 and 8 days in group 2. No side effects were detected. Meta-analysis included 792 patients: 392 patients in group 1 and 400 patients in group 2. Group 1 reported 211 stone expulsions (53.8%) and group 2 reported 332 expulsions [83%, χ2 = 78.17 (p < 0.01), RR = 1.54, absolute benefit = 29.2% (95% CI 23–35.3%), NNT = 3 (95% CI 3–4)]. The mean time to expulsion was 9.45 days in group 1 and 6.07 days in group 2 treated with tamsulosin; a significant difference was observed in all studies. Conclusions: Tamsulosin increases the elimination of distal ureter lithiasis of <10 mm.