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Hypouricemia, hypercalciuria, and decreased bone density: a hereditary syndrome.

Genetically determined hypouricemia in man due to increased renal urate clearance is usually associated with additional renal tubular defects (1–3). Renal hypouricemia due to an isolated renal tubular defect has also been described but appears to be a rare condition (4,5). We report a new genetically determined syndrome in man, in which the renal hypouricemia is associated with idiopathic hypercalciuria and decreased bone density.