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Investigation and application of novel adeno-associated viral vectors for Cystic Fibrosis gene therapy

48 Introduction 49 Materials and Methods 50 Results 53 AAV2H22 facilitates in vivo CFTR gene transfer to pig airway epithelia following apical instillation 53 Transgenic CFTR corrects chloride transport defect in vivo in the CF pig lung 56 Transgenic CFTR increases bacterial killing and pH in vivo in the CF pig lung 56 Discussion 58