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Differential Gene Expression in Cholesteatoma by DNA Chip Analysis

In contrast to normal epithelium, the desquamating stratified squamous epithelium of temporal bone cholesteatoma characteristically exhibits sustained hyperproliferative growth and a capacity for bone erosion. We conducted genome‐wide microarray analyses to determine the molecular nature of cholesteatoma's biological processes and identify disease‐associated, altered gene activity. We tested the hypothesis that genes contributing to the pathophysiology of cholesteatoma are differentially expressed compared to control tissue.