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Correlation of novel parameters of hypoxia during sleep and insulin resistance in non-diabetic patients with severe OSAS

Aim of our study was to explore the correlation of novel parameters of hypoxia during sleep and insulin resistance in non-diabetic patients with severe OSAS [Apnea Hypopnea Index, AHI>30/h]. Methods: 28 severe OSAS patients were diagnosed by polysomnography (PSG) with mean AHI 59.11±26.1/h, averSpO2 91.64±4.5%, and ODI 35.48±33.79/h. Novel parameters of hypoxia during sleep were analyzed, in the intervals with low values of SpO2 signal. The thresholds were set at 94% and 92% and the average value(M) of the SpO2 signal, in areas below thresholds, were calculated. The desaturations were analyzed, with their duration within the recording in terms of SpO2 signal parameters. Patients’ blood sample was analyzed in a fasting state. Results: A significant correlation between the average M92 value with insulin levels(r=0.401, p=0.03) and HOMA index(r=0.431, p=0.022) was observed as well as between the burden of desaturations and fasting glucose(r=0.4, p=0.035). Moreover, a significant correlation between the desaturations’ average value with insulin(r=0.378, p=0.047) and CRP(r=0.400, p=0.035) levels was also revealed. A strong correlation emerged from the cumulative desaturations’ duration as recorded by the SpO2 signal with fasting glucose levels(r=0.964, p Conclusions: Novel hypoxia parameters, derived from SpO2 signal analysis, are strongly correlated with insulin resistance in severe OSAS patients.