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Treatment of Facial Lentigines in Peutz–Jeghers Syndrome With an Intense Pulsed Light Source

BACKGROUNDPeutz–Jeghers syndrome is a hereditary condition characterized by distinctive mucocutaneous lentigines and intestinal hamartomatous polyposis. The cutaneous lesions may be cosmetically disfiguring and frequently present a therapeutic challenge. OBJECTIVETo determine if intense pulsed light (IPL) is effective in treating facial lentigines in Peutz–Jeghers syndrome. METHODSThe IPL, utilizing a 590 nm cutoff filter, was used to treat facial lentigines in a 10-year-old girl with Peutz–Jeghers syndrome. RESULTSA series of 12 treatment sessions, each to different facial regions, resulted in complete clearance of lentigines in the treated areas. Most of the lentigines resolved after a single treatment, with a few areas requiring a second treatment. CONCLUSIONIn this case, treatment with IPL resulted in dramatic improvement of cosmetically disfiguring lentigines. To our knowledge, this is the first report of using IPL in Peutz–Jeghers syndrome.