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Ganoderma Lucidum Subchronic Toxicity on The Liver As Anti-oxidant and Anti-inflamatory Agent for Cardivascular Disease

Background: Gonoderma lucidum is claimed to have beneficial health effects, and is developing into a comprehensive form of treatment against cardiovascular disease. Previous studies have successfully proven Ganoderma lucidum polysaccharides peptide ability as an antioxidant and anti-inflammatory agent whereby reducing levels of MDA, hs-CRP, H2O2, total cholesterol, foam cells as well as increasing the levels of HDL in experimental testing using Wistar rat (Rattus norvegicus strain wistar) fed with a high-fat diet. In order to develop Gonaderma lucidum polysaccharides peptide as an integral and comprehensive form of treatment against cardiovascular disease, further research regarding the subchronic toxicity on the liver was performed. Objective: To determine the safety profile of liver function in the use of Ganoderma lucidum polysaccharides peptide through subchronic toxicity studies on experimental animals. Method: The study of subchronic Ganoderma lucidum toxicity was performed using Wistar rat (Rattus novergicus strain wistar). 6 rats/sex/group were given a pure, freeze dried solution of Ganoderma lucidum with dosage ranging from 0,300, 600, 1200 mg/per kg body weight administered via gavage once a day for 90 days. Result : 90 days after the administration of pure, freeze dried Ganoderma lucidum solution with dosages ranging from 300 mg–1200 mg/per kg body weight, there were no observable toxic symptoms in male and female rats. There was no adverse effect on liver function with the administration of the maximum dosage (1200 mg/ per kg body weight). Gross pathology examinations of the rat's liver after the maximal dosage of Ganoderma lucidum extract proved to be unremarkable. These findings are supported by the results of clinical pathology and histopathology of liver cells which do not indicate a change in morphology and histopathology of the liver. Conclusion: The result of this study shows that oral administration of Ganoderma lucidum polysaccharides peptide until the maximum dose of 1200 mg/per kg body weight/day does not cause toxic effects in the liver.