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CHARCOT‐LEYDEN CRYSTALS IN HUMAN BONE MARROW

Summary Charcot‐Leyden crystals were found in reticulum cells and granulocytes of the bone marrow from patients with benign eosinophilia as well as from patients with myeloid but not lymphatic leukaemia. The crystals appeared similar to those prepared in vitro from the peripheral blood of patients with eosinophilia. Their origin from eosinophils is suggested by their occurrence in those cells, as well as by a correlation of the incidence of crystals in marrow with increased numbers of eosinophils. Structural anomalies of eosinophils that may be considered a primary component of a leukaemic process may predispose these cells to crystal formation. The crystals possibly arise, but less commonly, in basophils. Charcot‐Leyden crystals did not appear to be simple aggregates of the crystalloid material within normal granules of eosinophils and were not convincingly observed to arise in intact granules.