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DEVELOPMENT OF SPINDLE‐SHAPED CELLS AND CHONDROID CELLS FROM ANDROGEN‐DEPENDENT SHIONOGI CARCINOMA 115: A Light and Electron Microscopic Study

Androgen‐dependent Shionogi carcinoma 115 (SC115) is an undifferentiated medullary carcinoma consisting of compact round cells. However, when host male DS mice were castrated 2 weeks after tumor transplantation, tumors composed of compact round cells, spindle‐shaped cells and chondroid cells grew 4 weeks after castration. Compact round cells with desmosomes were arranged in solid nests and exhibited immunoreactivity for keratin protein. Spindle‐shaped cells had prominent rough endoplasmic reticulum, and appeared to secrete collagen. Chondroid cells had the characteristics of chon‐drocytes. The light and electron microscopic features were highly suggestive of a transition from compact round cells to spindle‐shaped cells, and from spindle‐shaped cells to chondroid cells. The histology of this tumor thus suggests that SC115 cells are able to change into chondroid cells via spindle‐shaped cells. ACTA PATHOL JPN 38: 1405–1416, 1988.