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Diagnostic and Therapeutic Value of Serum CA125,CA19-9 and CEA in Colorectal Carcinoma

Objective To evaluate the diagnostic and therapeutic value of serum CA125,CA19-9 and CEA in colorectal carcinoma.Methods A total of 82 patients with colorectal carcinoma had been treated surgically between June 2004 and June 2005.The control group included 41 healthy adults.The serum CA125,CA19-9 and CEA are determined by protein chip.Results The levels of serum CA125,CA19-9 were higher in the colorectal cancer group than in the control group.The positive rates of serum CA125,CA19-9 and CEA were not associated with location,gross morphology and histological type.The positive rates of three markers were higher in Duke's C+D than in Duke's A+B.The sensitivities of CA125、CA19-9、CEA were 34.1%、 34.1%、 30.5%,respectively.The specificities of them were all 97.6%.The combination of CA125,CA19-9 and CEA had a sensitivity of 58.5% and a specificity of 92.7%.However,it had a sensitivity of 86.8% and a specificity of 92.7% in Duke's C+D.Conclusion Serum CA125,CA19-9 and CEA as appropriate tools for diagnosis in colorectal cancer have not been proved to be ideal.Nevertheless,the combination of CA125,CA19-9 and CEA is important in diagnosis of colorectal carcinoma in Duke's C+D,and also may conduce to the determination of staging and operation radius in colorectal cancer.