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Advancement in Pharmacological Activities of Benzothiazole and its Derivatives:An Up to Date Review.

Benzothiazole is a heterocyclic aromatic and bicyclic compound in which, benzene ring is attached with thiazole ring. This nucleus is established in marine as well as terrestrial natural compounds. The benzothiazole skeleton is established in a broad variety of bioactive heterocycles and natural products. The benzothiazole nucleus is considered as the principle moiety in several biologically active compounds. Thus, over the decade, chemists are more and more paying attention towards the revision on the biological and therapeutic activities such including antimicrobial, analgesic, antininflammatory, antitubercular, antiviral and antioxidant of benzothiazole containing compounds. Additionally, the molecular structures of a number of potent drugs including Frentizole, Pramipexole, Thioflavin T and Riluzole etc are based on benzothiazole skeleton. The present work is the compilation and presentation of all available information in a systematic manner with an aim to present the findings in a way, which may be beneficial for future research.