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Stability Is Not Everything: The Case of the Cyclisation of a Thrombin‐Binding Aptamer

With the aim of developing a new approach to obtain improved aptamers, a cyclic thrombin‐binding aptamer (TBA) analogue (cycTBA) has been prepared by exploiting a copper(I)‐assisted azide–alkyne cycloaddition. The markedly increased serum resistance and exceptional thermal stability of the G‐quadruplex versus TBA were associated with halved thrombin inhibition, which suggested that some flexibility in the TBA structure was necessary for protein recognition.