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CAN ALBUTEROL HELP RESISTANCE EXERCISE ATTENUATE UNLOADING‐INDUCED BONE LOSS?

Hind-limb–suspended rats incur attenuated bone loss with b2-agonists, and humans note similar changes with concurrent resistance exercise. To examine if the b2-agonist albuterol helps resistance exercise reduce unloading-induced bone loss, human subjects performed 40 days of unilateral limb suspension with their left legs, otherwise refraining from normal ambulatory activity. While performing left leg strength training 3 days·week−1, subjects received a concurrent placebo or albuterol (16 mg·day−1) treatment. Left leg muscle and bone changes were analyzed with 2 × 2 analyses of covariance (ANCOVAs). Mechanical loading values were calculated from workouts and compared using a 2 × 5 analysis of variance (ANOVA) and a Tukey post hoc test. The resistance exercise–albuterol assignment evoked significant (p < 0.05) left leg bone mineral content (BMC) gains (12.24%) after 40 days. During the final unloading days, the resistance exercise–placebo group's mechanical loading data declined (213.91%) significantly (p < 0.05) versus initial values. A resistance exercise–albuterol assignment likely increased BMC by maintaining the mechanical loading stimulus.