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HLA STUDIES IN AUSTRALIAN MULTIPLE‐CASE FAMILIES OF JUVENILE ONSET DIABETES MELLITUS

The pathogenesis of insulin‐dependent diabetes mellitus (IDDM) will remain obscure until the number of genetic mechanisms contributing to susceptibility can be clarified. Australian multiple‐case families of IDDM have been examined for concordance in IDDM and HLA haplotypes and analysed for goodness‐of‐fit to hypotheses of one or two high‐risk susceptibility genes.