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The correlation between aspirin resistance and single nucleotide polymorphisms

Objective: To understand whether a group of 7 candidate single nucleotide polymorphisms(SNP) in 4 genes in the platelet aggregation pathway are associated with aspirin resistance. Methods: A total 320 patients who were taking aspirin were enrolled from October 2010 to March 2012. COX-1, COX-2, GP IIIa, P2Y1 gene polymorphisms were analyzed by polymerase chain reaction and DNA sequencing assay. Results: One of SNPs in which a C was substituted for T base at position 893 of the P2RY1 gene (P2RY1_1) was associated with the increase of aspirin resistance(OR 3.16, 95% CI 1.36-7.16, P=0.04). None of the polymorphisms examined in the ITGB3, PTGS1 or PTGS2 genes had a significantly increased risk for aspirin resistance. Patients with aspirin resistance were older and more often had diabetes mellitus and a lower total HDL levels than those who were aspirin sensitive. Conclusion: There are correlation between mutation of P2RY1 gene and aspirin resistance.