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Evaluation of Anti‐inflammatory and Analgesic Activity of a Novel Rigid 3, 4‐Dihydroxy Chalcone in Mice

There have been many reports indicating the analgesic and anti‐inflammatory effects of 3,4‐dihydroxychalcones. We have designed and synthesized a rigid 3,4‐dihydroxychalcone (RDHC) as a possible drug effecting inflammation and nociception. The analgesic and anti‐inflammatory effects were evaluated by formalin and hot‐plate tests, respectively. The results showed that RDHC induced significant antinociceptive and anti‐inflammatory effects (P < 0.01). Maximum analgesia (63.7%) was observed at 37.5 mg/kg in the first phase of the formalin test. The effect of RDHC was higher in the chronic phase (inflammation phase) of the formalin test (86.4%, P < 0.01). In addition, a significant analgesia (maximum possible effect; MPE = 30.1%) was observed in the hot plate test 45 min after injection of 37.5 mg/kg RDHC (P < 0.01). As a result of our findings, this new RDHC could be suggested for further pharmacological studies.