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A Stability-Indicating HPLC Method to Determine Celecoxib in Capsule Formulations

ABSTRACT A simple and accurate high-performance liquid chromatographic (HPLC) method was developed to determine Celecoxib in capsule formulations. The drug was chromatographed on a reversed-phase C-18 column. Eluents were monitored at a wavelength of 251 nm using a mixture (85:15) of methanol and water. Solution concentrations were measured on a weight basis to avoid the use of an internal standard. The method was statistically validated for linearity, accuracy, precision, and selectivity. Due to its simplicity and accuracy, we believe that the method will be useful for routine quality control analysis.