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From the authors

Fourthly, the menopause and menstrual cycle significantly affect sleep apnoea and endothelial function [7, 8]. The menopausal transition is significantly associated with an increased likelihood of having sleep-disordered breathing, independent of known confounding factors [7]. FMD increases in menstrual phase, when serum oestradiol level is low and the value is comparable to that in male subjects [8]. Because endothelium-dependent vasodilatation varies during the menstrual cycle, the timing of FMD measurements of female subjects is critical for the precise assessment of allopinol effects.