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Depression in cardiac contractile force induced by cholesterol.

Cholesterol, combined with albumin, induced rapid functional changes in the isolated perfused rat heart. Under constant perfusion pressure, the decline in contractile force and the rate of development of force due to cholesterol was accompanied by an increase in resting tension and a decrease in coronary flow. Such effects were not produced by albumin alone. Depression in contractile force and increase in resting tension were also evident when coronary flow was kept constant; these effect of cholesterol were dependent on time and dose. The findings support the view that cholesterol may affect cardiac function independently of the atherosclerotic lesion in the hypercholesterolemic state.