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Evaluation of the Therapeutic Efficacy of some Antimuscarinics against Soman in Vivo

The therapeutic efficacy of tacrine, atropine and glycopyrrolate alone or in combination with the oxime HI‐6 against soman was evaluated in anaesthetized rats. Arterial blood pressure, heart rate, respiratory frequency and body temperature were monitored in vivo. Blood cholinesterases were determined after each drug or soman challenge. At the lowest concentration tested (2.5 mg kg−1), tacrine was effective in improving the survivability of the rat by a factor of 2.6 (protection ratio), whereas the protection by atropine or glycopyrrolate was either insignificant or only marginally effective (protection ratio ranged from 1.0 to 1.9). In combination with HI‐6, atropine increased the ratio to 4.6. In contrast, tacrine with HI‐6 failed to improve the efficacy of the regimen, while glcopyrrolate plus HI‐6 showed only slight improvement.