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Effects of anoxia and hyperbaric oxygenation on the transmembrane action potential of the rat heart in situ.

The benefit of hyperbaric oxygen (HBO) on the anoxic myocardial tissue was tested by measuring the transmembrane action potential (TAP) which reflects the across the cell membrane. The study was performed on 150 living, anesthetized rats, using the floating microelectrode technique. In a first group, with anoxia by tracheal occlusion, the changes in frequency and amplitude of TAP are delayed when operating at 3 ata pressure of oxygen. Likewise, in a second group with coronary artery occlusion, the TAP in infarcted areas is less affected during oxygen breathing at 3 ata. It is concluded that HBO is beneficial under these experimental conditions.