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Submicron-fabrication of bovine serum albumin (BSA) matrix via two-photon photochemical crosslinking

We present the successful fabrication of bovine serum albumin matrix with novel two-photon photochemical crosslinking technique. Electron scanning microscope images revealed the highly porous microstructures of as-fabricated matrices. Dose dependence of the microstructures on both BSA and Rose Bengal has been studied. 2D patterns and 3D micropillars of BSA have also been fabricated, which potentially can be used as a model of cell-matrix study.