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A Comparative Study of Time Dependent Candidal Colonisation in Diabetic and Non-diabetic Complete Denture Patients

Introduction: Acrylic dentures are important predisposing factors for oral candidiasis. Duration of wearing dentures in the oral cavity of diabetic and non-diabetic patients can increase Candida colonisation and results in the higher incidence of oral and systemic candidiasis. Aims and Objective: 1. To compare the changes in Candidal colonisation with time in complete denture prosthesis in diabetics and non-diabetics. 2. To evaluate the change in Candidal growth in diabetics and non-diabetic complete denture wearers. 3. To evaluate the relation of time with Candidal growth in complete denture wearers. Materials and Methods: Three Salivary samples from each 20 edentulous, non-insulin dependent diabetic and 20 edentulous (Group-1), non-diabetic subjects (Group-2) were collected at 3 different time intervals. First sample was collected on the day of denture insertion, the second sample after one week from the day of insertion and third sample, after one month from the day of denture Original Research Article Ashraf et al.; JAMMR, 27(6): 1-8, 2018; Article no.JAMMR.43719 2 insertion in sterile containers using oral rinse technique. All samples were cultured directly on Sabouraud agar medium and species identification was done by HiCrome Candida Differential Agar culture methods. Results: Candidal carriage and colonisation is more in diabetic denture wearer patients than nondiabetic denture wearer patients. Candidal growth in complete denture wearers was significantly increased from Day 1 to last day of 1 week (p=0.006), Day 1 to last day of 1 Month (p=0.005) and last day of 1 st Week to last day of 1 st Month (p=0.007) in Group 1. There was significant mean change in Group 2 from last day of 1 Week to last day of 1 Month (p=0.001). The common species of Candida isolated in both diabetic and non-diabetic denture wearer patients are: C. albicans, C. glabrata and C. tropicalis.