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High numbers of macrophages, especially M2‐like (CD163‐positive), correlate with hyaluronan accumulation and poor outcome in breast cancer

High amounts of tumour‐associated macrophages (TAMs) and hyaluronan (HA) correlate with tumour aggressiveness in breast cancer, but the relationship between these parameters is unclear. The aim of this study was to assay the numbers of TAMs in 278 human breast cancer cases, and their correlations with HA‐related factors, clinical variables, and outcome.