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Colorectal-cancer screening--coming of age.

The Minnesota Colorectal Cancer Control Study showed 20 years ago that the annual use of the guaiac fecal occult-blood test decreased mortality from colorectal cancer by 33%.1 A few years later, colorectal-cancer screening was endorsed by multidisciplinary guidelines2 and was covered by insurance,3 leading to an increase in the performance of colorectal-cancer screening tests. Two articles in this issue of the Journal provide evidence of what colorectal-cancer screening can accomplish over the long term.4,5 Nishihara and colleagues4 found decreased risks of colorectal cancer and death from colorectal cancer associated with screening colonoscopy and sigmoidoscopy, following two well-described prospective cohorts . . .