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Total pancreatectomy and islet cell autotransplantation: Definitive treatment for chronic pancreatitis

Most patients report less pain after this procedure, and many avoid overt diabetes. In appropriately selected patients, total pancreatectomy and islet cell autotransplant controls pain and improves quality of life while often minimizing the development of overt diabetes. Multidisciplinary management and lifelong follow-up help to maximize the benefit of this procedure. This review highlights its history, indications, metabolic outcomes, and future directions.