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A case of systemic sclerosis with anticentromere, antitopoisomerase I, and anti-U1RNP antibodies.

We describe a case of systemic sclerosis (SSc) positive for 3 autoantibodies; anticentromere antibody, antitopoisomerase I antibody, and anti-U1RNP antibody, It is known that coexistence of 2 of these 3 antibodies is rare and the coexistence of these 3 antibodies in serum from a patient with SSc has not been reported. In addition, we examined our stock serum samples from 236 cases with SSc or related disorders for the presence of specific antinuclear antibodies and were unable to find a serum sample containing all 3 antibodies.