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Addition of trazodone to sertraline: a probable synergistic action in a case of obsessive-compulsive disorder.

Dear Editor, Despite the considerable advances made with the introduction of the serotonin reuptake inhibitors (SRIs) into clinical practice, 40-60% of the subjects still fail to respond adequately to the initial therapy. Preliminary evidence supports the addition of antipsychotics, mainly atypical, to SRIs in obsessive-compulsive disorder (OCD). These agents combine serotonin-dopamine antagonism with the advantage of being well tolerated, including a low potential for inducing motor side-effects. In contrast, other serotonergic medications do not show satisfactory results as adjuvant treatments in treatment-refractory OCD.