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The Effect of Nimodipine on Calcium Current of Neurons after Brain Impact Injury

Aim: To study the alteration of neuronal calcium currents after brain injury and the effect of antagonist of Ca 2+ channels on the currents. Methods: The brain impact injury in Wistar rats was made by a free drop impacting device. Neurons around the traumatic area and in the same area of the opposite semisphere were isolated by enzymatic and mechanical method and the voltage dependent calcium currents (I Ca ) in these neurons were recorded with the whole cell patch clamp technique. Results: I Ca of traumatic neurons was -240±46pA( n =6) and I Ca of normal neurons was -143 ±38pA ( n =8). The increasing rate of I Ca in traumatic neurons was 68.5%. After irrigating nimodipine 10 μmol/L I Ca was -108±37pA( n =6) in the traumatic neurons, and -112±35pA( n =6) in the normal neurons. The decreasing rates of I Ca were 55.0% in the traumatic neurons and 21.6% in the normal neurons. Conclusion: The influx of Ca 2+ increased much more in the injured neurons than in the normal neurons. The effect of nimodipine on the reduction of I Ca is more effective in the traumatic neurons than in the normal neurons. Nimodipine could inhibit the inflow of Ca 2+ into the neurons. Therefore, neuronal damage may be reduced by nimodipine after brain injury.