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SPARC: 
Found in translation: quantitative predictors of cardiac myocyte responses to β‐adrenergic stimulation across species

Despite strong evidence of the fundamental connection between the brain and the heart, there is still a poor quantitative and functional understanding of the role of autonomic regulation in normal cardiac excitation‐contraction coupling and pathophysiology, including arrhythmias or contractile dysfunction. The intrinsic electrophysiologic differences across various animal models and species upon which our knowledge is based might be a contributing factor to this limited understanding. Indeed, by simulating our multi‐species computational framework for simulation of excitation‐contraction coupling and β‐adrenergic signaling in mouse, rabbit and human ventricular myocytes, we have shown that the well‐conserved fight‐or‐flight response is mediated by different sub‐cellular processes in rodents vs. larger mammals.