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Peculiarities of pregnancy course and outcome in women with confined placental mosaicism

The pregnancy complications and perinatal outcomes in 12 patients with confined placental mosaicism (CPM) were studied. Among them abnormal high level of MShCG (2MoM) was noticed in five patients. Increased resistance in the uterine artery was found at 20 and 36 weeks of pregnancy in women with CPM. Stillbirth was registered in 1/3 of cases; intrauterine growth retardation was detected in j of patients. Morphological signs of the placental insufficiency and villi immaturity were detected in all placentas. Our data reflect a possible negative influence of CPM to the pregnancy outcomes.