{'fraction_non_alphanumeric': 0.019550342130987292, 'fraction_numerical': 0.013685239491691105, 'mean_word_length': 5.7368421052631575, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Wrestling with a Contortionist: Structural Studies on the Rotavirus Membrane Penetration Protein, VP4

CHESS News Magazine 2005 Page 53 Rotavirus is the most important cause of dehydrating childhood gastroenteritis, worldwide. Although children everywhere are infected by this virus, the most significant impact is felt in poor countries, where approximately 500,000 children die from rotavirus gastroenteritis each year. (Rotavirus biology and epidemiology are reviewed in reference [1].) Antibodies that neutralize the virus can protect from disease, provided that they are present in the gut lumen during infection. These protective antibodies bind the moving parts of the molecular apparatus that the virus uses to enter cells. Many neutralizing antibodies against rotavirus bind specific conformations of their targets. Therefore, a high resolution understanding of the structural basis for rotavirus entry could allow a structure-based approach to optimizing antigens for use in a second generation rotavirus vaccine.