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The determination of the endogenous antimicrobial peptides in acute calculous cholecystitis

The aim  — to perform comparative study of some antimicrobial peptides level in various forms of acute calculous cholecystitis (ACC). Materials and methods. The levels of HNPa, BPI, endotoxin, neutrophil elastase, lactoferrin, hepcidin in blood plasma, as well as hepcidin in liver tissue taken during surgery were studied in 69 patients with catarrhal (n = 26), phlegmonous (n = 24) and gangrenous form (n = 19). Results and discussion. There was a significant increase in the rates of all antimicrobial peptides studied in plasma, and hepcidin in liver compared to the control group ones. It was found that the destructive ACC forms caused the highest content of all the studied indicators. Positive correlations between the levels of antimicrobial peptides studied were found. Conclusions. The preoperative level of some antimicrobial peptides studied can be used in the early diagnosis of destructive forms of ACC.