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Predictability of immunologic phenotype of malignant lymphomas by conventional morphology. A study of 60 cases

In order to test the immunologic validity of the Lukes‐Collins (L‐C) classification of the non‐Hodgkin's lymphomas (ML), 60 ML in adult patients were studied and their B‐ or T‐cell nature was predicted on a morphologic basis, without knowledge of the clinical history or the results of surface marker (SM) studies (SIg, C', Fc and E‐rosettes), which were performed on cell suspensions and cryostat sections from the same specimens used for histology. There was a good correlation between morphologic types and SM (97% for the nodular ML, 81% for the diffuse). The predictions were not confirmed in 6 instances: one nodular ML typed as T; one convoluted lymphocytic ML typed as histiocytic; and four diffuse ML, predicted to be of B‐type, bore no detectable SM (“Null” ML). It is concluded that the L‐C morphologic criteria do allow in most cases the recognition of the B‐ or T‐cell nature of ML, but cannot detect variations of the SM pattern which seem to affect the clinical behavior of these neoplasias.3 Thus, while the L‐C classification seems immunologically sound, its clinical relevance still needs to be demonstrated.