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[Interrelation between levels of eicosanoids and tachykinins in the expired air condencate in the obstructive type respiratory insufficiency in patients with destructive pulmonary tuberculosis].

The content was studied of vasoactive intestinal peptide (VIP), substantia P (SP), bombesine (BMB), prostaglandins (PG) E2, F2alpha, 6-keto-F1alpha, Tx A2, and leukotrien (LT) B4 in the expired air condensate with the aid of the radioimmune technique to reveal a relation between pulmonary tachykinins and eicosanoids in obstructive type respiratory incompetence in patients with pulmonary tuberculosis. In patients with pulmonary tuberculosis, a high level of BMB was measurable in the expired air condensate. A linear negative correlation has been established between BMB content and forced expiratory volume, SP and respiratory volume, SP and lung capacity. In pulmonary tuberculosis, PGE2 and PGF2alpha levels are significantly evaluated. There was a positive correlation between BMB content and PGF2a in the expired air condensate, which fact suggests their synergic action on the smooth muscles of the bronchi and bronchioles.