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EXCRETION OF FREE AND CONJUGATED 5‐HIAA AND VMA IN URINE AND CONCENTRATION OF 5‐HIAA AND HVA IN CSF DURING MIGRAINE ATTACKS AND FREE INTERVALS

The DIAGNOSIS OF migraine is still based on clinical findings. However, everyday practice has forced us to check our attitude to old ideas. According to Water's study only half of migraine patients are releaved by ergotamine in their headache attacks (Waters, Brit. Med. J. 1970, 2, 325). Blau, again, has found that in one half of the patients the conjunctival blood vessels contract during attacks. Contraction and dilatation remain the same in successive attacks and support the view that also intracranial vessels take part in the headache stage (Blau, Lancet 1970, 10, 740). Anthony and Lance have shown by biochemical methods that migraine and cluster headache are two different forms of headache (Anthony and Lance, Arch. Neurol. 1971, 25, 225).