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Hepatoprotective Activity of Some Indigenous Plants of Northern India Against Chronic Paracetamol Intoxication in Rats

Liver diseases have become a global concern worldwide. Liver injury or its dysfunction is a major health problem. The principal causative factors for liver injury are the availability of hepatotoxic drugs, alcohol consumption, infection, malnutrition, anemia etc. In the present study the hydroalcholic extract of some plants of northern India was evaluated for hepatoprotective activity against chronic paracetamol induced hepatotoxicity in rats. The liver injury was induced by Paracetamol orally at a dose of 500 mg/kg, b.w for entire duration of study. The rats were divided in nine groups. Rats of group I served normal control and received distilled water. Rats of group II served as toxic control and received Paracetamol orally at a dose of 500 mg/kg, b.w of rats. Group III received Silymarin at a dose of 100 mg/kg b.w, and served as standard. The animals of groups IV, V, VI, VII, VIII and IX served as test control groups. Protective effect of the hydroalcholic extract was assessed by measuring the levels of serum biomarkers such as SGOT, SGPT, ALP, Bilirubin, serum albumin and total protein. Results of this study showed that the treatment of the hydroalcholic extract of plants at 400 mg/kg b.w, showed significant (*** p less than 0.001) reduction in elevated serum enzyme levels compared to paracetamol induced toxic group, indicating the protective role of plants extract against paracetamol induced chronic liver toxicity. Among the all plants Calotropis procera at a dose of 400 mg/kg, b.w showed the most significant hepatoprotective activity.