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[Morphological changes of the endometrium and ovary (optical and electronic microscopic observations) and their functional reversibility after prolonged use of synthetic estroprogestogens].


 This study reports on the case of a 32-year-old patient who had been on OCs (oral contraceptives) for only 12 months, who was hospitalized for adnexial tumefaction. Am ovarian biopsy was done by observing with the optic and with the electronic microscope the modifications caused by the treatment on the ovary and on the endometrium. The observations revealed such serious pathological and degenerative modifications that the patient was recalled after 7 years to conduct the same kind of observations. On that occasion it was established that the patient, who has stopped hormonal contraceptive use, had resumed normal ovulatory capacity, and that hypophysary and ovaric secretions were absolutely normal. It is doubtful whether a longer period of OC use would allow the ovary to retain its ability to resume complete regular functions.
