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HIV‐1‐based defective lentiviral vectors efficiently transduce human monocytes‐derived macrophages and suppress replication of wild‐type HIV‐1

Human monocytes play an important role in mediating human immunodeficiency virus type 1 (HIV‐1) infection of the central nervous system (CNS), and monocytes‐derived macrophages (MDM) represent a major viral reservoir within the brain and other target organs. Current gene transduction of MDM is hindered by a limited efficiency. In this study we established a lentiviral vector‐based technique for improved gene transfer into human MDM cultures in vitro and demonstrated significant protection of transduced MDM from super‐infection with wild‐type HIV‐1.