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Exercise‐induced liver chemokine CXCL‐1 expression is linked to muscle‐derived interleukin‐6 expression

Non‐technical summary  Exercise is known to stimulate the production of various exercise factors including the well‐described muscle‐derived interleukin‐6 (IL‐6). We show that exercise causes a massive expression of the chemokine CXCL‐1 in serum, in skeletal muscle and especially in the liver. Furthermore we find that this exercise‐induced liver CXCL‐1 expression is regulated by IL‐6 and that muscle‐derived IL‐6 is capable of stimulating liver CXCL‐1 expression. Such knowledge of the regulation of exercise factors contributes to the understanding of how the liver and muscle communicate in response to exercise.