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PERINATAL INFLAMMATION AND INTRAUTERINE GROWTH RETARDATION ARE BOTH ASSOCIATED WITH LUNG FUNCTION IMPAIRMENT AT 12 YEARS OF AGE IN VERY PRETERM INFANTS

PERINATAL INFLAMMATION AND INTRAUTERINE GROWTH RETARDATION ARE BOTH ASSOCIATED WITH LUNG FUNCTION IMPAIRMENT AT 12 YEARS OF AGE IN VERY PRETERM INFANTS Introduction: Pulmonary disease after very preterm birth may cause permanent lung damage and as a consequence, lung function impairment in long-term survivors. Perinatal inflammation is one of several identified risk factors. Aim and objectives The aim of this study was to evaluate if systemic inflammation early after birth in very preterm infants was related to lung function at preadolescent age. Methods: Spirometry and diffusing capacity was done at 12 years of age in 54 children, born at gestational age of 27.8 weeks. Lung function parameters were compared with inflammatory biomarkers (IL-6, IL-8 and IL-10) previously analyzed from cord blood and at 6, 24 and 72 h after birth. Mean cytokine levels were calculated by area under curve (AUC). BPD was defined as need for supplemental oxygen at 36 weeks PMA. Results: Weight deviation at birth was associated with a lower diffusing capacity (p=0,005) and a lower alveolar volume (p=0,009) at 12-13 years of age. Infants diagnosed with BPD had higher AUC for IL-6, IL-8 and IL-10 in the first 72 h after birth (p=0.009, p There were a significant inverse correlation between AUC for IL-6 in the first days of life and FEV1 (p=0,006) and MMEF25-75 (p=0,019) at 12-13 years of age. Conclusion: The presence of growth retardation at birth as well as perinatal inflammation were risk factors for later impaired lung function at the age of 12. Long term follow up with lung function tests might be useful in infants with specific risk factors.