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Intravascular Large B Cell Lymphoma: A Rare Case Report

Diffuse large B-cell lymphoma is a common hematological malignancy that usually presents with signs of peripheral lymphadenopathy, hepatosplenomegaly, and bone marrow suppression, and/or symptoms such as fever, night sweats, and weight loss. Intravascular large B-cell lymphoma is an aggressive and rare tumor characterized by neoplastic cells’ tendency to remain in the vessel. Most of the patients are in the middle or advanced age group. The symptoms are related to the lesions caused by the tumor cells’ occlusion in the small vessels. Findings related to the central nervous system (convulsions, neurological deficits, progressive dementia) or skin involvement (subcutaneous nodules, plaques) are frequently observed. In patients with skin lesions, the prognosis is better than those with only central nervous system involvement, as early diagnosis can be made by skin biopsy.