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Changes in Subcutaneous Interstitial Fluid Pressure, Tissue Oxygenation, and Skin Red Cell Flux during Venous Congestion Plethysmography in Men

Objective: Venous congestion plethysmography enables noninvasive assessment of microvascular filtration capacity (Kf) in limbs. However, increases in fluid filtration might alter the balance of Starling forces; for example, progressive increases in interstitial fluid pressure (Pi) would reduce net fluid flux, thus underestimating Kf. Furthermore, elevation of cuff pressure to values close to diastolic blood pressure, as used in the protocol, may by itself impair tissue perfusion with unknown effects on the microvascular parameters investigated.