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Blockade of the Tonic Hindlimb Extensor Component of Maximal Electroshock and Pentylenetetrazol‐Induced Seizures by Drugs Acting on Muscle and Muscle Spindle Systems: A Perspective on Method

Blockade of tonic hindlimb extension (THE) in the maximal electroshock seizure test was demonstrated for C‐28 ‘882‐Ba, a muscle spindle suppressant, chlorpromazine, a depressant of fusimotor drive, and gallamine, a neuromuscular blocking drug. These agents also blocked THE produced by very large doses of pentylenetetrazol. Dantrolene, a muscle contraction antagonist, and MI‐65‐S, a muscle spindle suppressant, significantly delayed THE. The data indicate that blockade of THE may be effected at a multiplicity of loci and may not be an expression of an “anticonvulsant” effect.