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From fish to nephrology: modelling glomerular function in Danio rerio larvae

The assessment of the glomerular filtration rate (GFR) is essential to judge renal function in clinical practice. Estimated GFR based on serum creatinine concentration is useful as a “first line” test of kidney function, whereas measured GFR using urinary or plasma clearance of exogenously applied markers of filtration provides more accurate information and allows conclusions on the function of the filtration barrier and the tubular reabsorptive capacity (Stevens & Levey 2009). Defects of the glomerular filtration barrier may impair size selectivity and cause proteinuria, leading to chronic kidney disease. 
 
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