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Malignant fibrous histiocytoma a retrospective study of 167 cases

A retrospective study of 167 patients with soft‐tissue malignant fibrous histiocytoma of the trunk, extremities, and retroperitoneal region revealed twice as many deeply situated tumors as superficial tumors. Malignant fibrous histiocytoma may be subclassified into fibrous, giant‐cell, myxoid, and inflammatory variants. The fibrous variant accounted for two‐thirds of the lesions. The prognosis is no different among the histologic subtypes. The depth of the tumor significantly affects survival, and three important groups were identified: superficial tumors, superficial tumors that recur in deep locations, and deeply situated tumors. The group with superficial tumors that subsequently did not recur in deep locations had a significantly better 4‐year survival rate than did the other two groups (65% versus 34% and 40%, respectively). Patients with distally located tumors had a better 5‐year survival rate than did patients with proximally located tumors (73% versus 28%). Local recurrence was found in 51% of patients who had a “complete” excision. Patients with superficial tumors had a higher local recurrence rate (71%) than did those with deep tumors (41%). Few patients with retroperitoneal tumors were long‐term survivors; the 5‐year survival rate was 14%.