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Abstract 137: Negative Pressure Wound Therapy with Instillation Accelerates the Granulation Response with Gene Expression Variations While Maintaining Comparable Tissue Quality Compared to Continuous and Non-Continuous Negative Pressure Wound Therapy in a Porcine Model

PurPose: Negative pressure wound therapy (NPWT*) can be coupled with automated delivery and removal of topical wound treatment solutions and suspensions (NPWTi†) or delivered in either continuous or non-continuous modes. This porcine study compared the granulation response, genomic response, and resulting tissue quality of NPWTi using normal saline with instillation foam dressing‡ to NPWT using standard foam dressing in continuous and non-continuous modes. The quality of the resulting granulation tissue was assessed using these key measures: collagen content, angiogenesis, extracellular matrix components, and cellular energetics.