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NON‐SPECIFIC REGULATION OF IMMUNE RESPONSIVENESS TO A THYMUS‐INDEPENDENT ANTIGEN, TNP‐LPS, IN HIGH AND LOW RESPONDER LINES OF MICE

Responsiveness to a thymus‐independent (TI‐1) antigen, TNP‐LPS, was investigated in the high and low responder lines of mice resulting from four independent selective breedings carried out for antibody production to various complex natural immunogens (selections I, III, IV and V). The superiority of the high responder vs. the low responder line was generally observed, confirming that the genes accumulated through selective breeding can modify the responsiveness to unrelated antigens including TI antigens.Two special features were observed in selection III: (1) A secondary response to TNP‐LPS: higher peak values and IgG isotype antibody production were obtained in the H line. (2) Pretreatment with LPS modified the responses to TNP in the L line only.