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Salt Screening and Selection

Salt screening and selection is a critical factor for the developability of an active pharmaceutical ingredient (API). The main benefit to screening, identifying, and selecting the optimal salt form early in the lifecycle is to improve the bioavailability of the compound while addressing its associated physicochemical, stability, and mechanical properties. The role of the scientist in the screening process involves the selection of the counterions and solvents and to bring valuable experience during the crystallization process. There are numerous manual and automated assisted strategies across the pharmaceutical industry for salt screening; however, determining crystalline salts that have a low potential for polymorphism is the common goal. The selection of the optimal salt not only improves the manufacturing and marketability of the drug product but also positions and protects the intellectual property of the product through composition of matter patents. 
 
 
Keywords: 
 
salt screening; 
salt selection