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Preliminary data on the use of intraductal optical coherence tomography during ERCP for investigating main pancreatic duct strictures

Optical coherence tomography (OCT) is an optical imaging technique that uses infrared light reflectance and produces high resolution microstructural cross sectional images of tissues in vivo.1–3 The OCT probe can be inserted inside a standard transparent endoscopic retrograde cholangiopancreatography (ERCP) catheter. To date, only the epithelium of the main pancreatic duct (MPD) has been examined by OCT in humans in three studies: one post mortem4 and two ex vivo.5,6 The aim of the present prospective pilot study was to assess the feasibility of intraductal OCT in vivo during an ERCP procedure, its ability to identify changes in MPD wall structure in vivo, and its ability to differentiate non-neoplastic from neoplastic tissue in the presence of MPD strictures.

Fifteen consecutive patients with documented or suspected MPD strictures …