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Functional expression of SK channels in murine detrusor PDGFRα+ cells

•  SK currents have been recorded from detrusor smooth muscle cells, but current density at physiological holding potentials is negligible. •  We discovered a new class of interstitial cell in the bladder that were identified using antibodies against platelet‐derived growth factor receptor‐α(PDGFRα+ cells). •  SK3 channel transcripts and protein are highly expressed in PDGFRα+ cells in comparison to smooth muscle cells. •  Current density attributable to SK‐like currents is much higher in PDGFRα+ cells than in smooth muscle cells. Single channel currents, consistent with the conductance and Ca2+ sensitivity of SK3 channels were measured in PDGFRα+ cells. •  The abundance of SK3 channels in PDGFRα+ cells in detrusor muscles suggests that PDGFRα+ cells, not SMCs, provide apamin‐sensitive regulation of detrusor excitability.