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EPV131/#545 Lower uterine segment involvement in high-grade endometrial carcinoma is not independently associated with adverse oncological outcome

0.48–6.34, p=0.39) for LVSI and 1.70 (95% CI 0.43–6.75, p=0.44) for LNM. Conclusions The rate of LVSI and LNM showed a significantly increasing trend from u-POLE to p53-mutated. Among the MMRd and LCN molecular subtypes with intermediate prognostic impact, where the classical prognostic parameter may have a role, MMRd patients had a higher, although not significant, risk of LVSI and LNM. The reduced number of patients, which is one of the limit of the study may explain the lack of significance. Larger studies are suggested.