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Effect of High‐intensity Interval Training and Moderate‐intensity Continuous Training on Circulating MicroRNAs in Sedentary Males

Circulating microRNAs (c‐miRs) serve as the reliable biomarkers for exercise adaption. The present study aimed to clarify the relationships between changes of c‐miRs expressions and aerobic capacity/hemodynamic functions caused by various exercise regimens in men. Twenty‐four healthy sedentary males were randomized to engage in either high‐intensity interval training (HIIT, 3‐minute intervals at 40% and 80% of VO2max, n=12) or moderate‐intensity continuous training (MICT, sustained 60% of VO2max, n=12) for 30 minutes/day, 5 days/week for 6 weeks. Various c‐miRs involved in angiogenesis (miR‐126), cardiac hypertrophy (miR‐222, miR‐221), and hypoxia/ischemia adaptation (miR‐21, miR‐146a) were measured by qRT‐PCR, respectively. The analyzed results showed that 6‐week HIIT and MICT significantly enhanced VO2max, which were accompanied by increased stroke volume and cardiac output during exercise. Moreover, both HIIT and MICT increased expressions of miR‐126 (1.49±0.03 and 1.27±0.09 folds) and miR‐222 (1.32±0.10 and 1.25±0.15 folds), respectively. Additionally, HIIT elevated miR‐146a expression (1.33±0.09 folds), whereas MICT upregulated miR‐21 (1.32±0.08 folds). However, no significant change in plasma miR‐221 level was occurred after both HIIT and MCT. Therefore, we conclude that the exercise‐induced cardiovascular adaptions are associated with the changes of angiogenesis/hypertrophy‐related c‐miRs following either HIIT or MCT.