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Enhancing recruitment and retention in randomized clinical trials of cancer symptom management.

PURPOSE/OBJECTIVES
To describe techniques to overcome challenges of collaborating with multiple clinical sites and participants to enhance recruitment and retention for cancer symptom management randomized clinical trials (RCTs).


DATA SOURCES
Personal experiences and publications related to recruitment and retention of sites and participants in RCTs, which were found by searching MEDLINE, CINAHL, and PsycINFO records.


DATA SYNTHESIS
Techniques to overcome challenges related to multisite research, patient confidentiality guidelines, and work with an at-risk population were identified and applied successfully in an RCT designed to modify fatigue during and following adjuvant breast cancer chemotherapy.


CONCLUSIONS
Successful recruitment and retention depended on the value that site personnel placed on symptom management research, identification of a designated contact person at each site, and flexibility in maintaining communication among the project director, contact individuals, and participants.


IMPLICATIONS FOR NURSING
Initial and ongoing collaboration with participants and a contact person at each site, assurance of privacy of protected health information, and emotional support are critical to recruitment and retention throughout cancer symptom management RCTs.