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Saporin Conjugated with Transforming Growth Factor-α Inhibit Neointimal Proliferation by Specific Cytotoxicity

Objective This study aimed to investigate the Cytotoxic effects of TGFα-SAP on the inhibition of neointimal proliferation after rat common carotid arterial injury. Methods seventy rats were divided into two groups. The TGFα-SAP treated group was treated with local injection of TGFα-SAP (5μg/kg) after injury, and the control group was treated with saline. Rat arterial segment was investigated at 1, 3, 9, and 28 days after operation. Results Compared to the control group, the TGFα-SAP treated group shows a significant inhibition of intimal thickness. Conclusion The results indicated that TGFα-SAP can effectively inhibit neointimal proliferation following arterial injury .