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OUTCOME AT THREE YEARS OF SICK NEONATES INVOLVED IN A DOUBLE‐BLIND TRIAL OF TWO PARENTERAL AMINO ACID PREPARATIONS

The authors investigated the hypothesis that neonates who received a parenteral amino acid preparation causing high plasma amino acid levels in the first week of life would perform less well at follow‐up than those who received a preparation in which the plasma aminogram fell persistently within the normal range. 27 surviving children who had received either preparation as neonates underwent psychometric assessment at three years. Parents completed three questionnaires about temperament, behaviour screening and socio‐economic status. Four of 10 patients who had received one preparation and two of 17 infants who had received the other were of below‐average intelligence. This may be related to the different amino acids in the mixtures and the hyperamino‐acidaemia caused by this.