{'fraction_non_alphanumeric': 0.04231931849409178, 'fraction_numerical': 0.03187688925528991, 'mean_word_length': 4.977011494252873, 'pattern_counts': {'":': 0, '<': 2, '<?xml version=': 0, '>': 1, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Safety and Efficacy of Stent‐Supported Thrombolysis in Acute Ischemic Stroke

Stroke is the primary cause of disability and death worldwide, of which ischemic stroke accounts for 70–85% of stroke events [1]. Acute arterial stenosis or occlusion is responsible for 70% of ischemic stroke. Thrombolysis in ultra-early stage can get recanalization and improve outcome. Besides the traditional intravenous thrombolysis, novel techniques for recanalization of occluded arteries, including mechanical opening techniques [2, 3] have developed in recent years. This study compared the safety and efficacy of pharmacologic thrombolysis and stent-supported thrombolysis in acute ischemic stroke, in an aim to identify an optimal strategy for treatment of ischemic stroke. Thirty-four patients with acute cerebral infarction due to occlusion or ≥50% stenosis in middle cerebral artery (MCA) or intracranial internal carotid artery were retrospectively studied. Nineteen patients underwent pharmacologic thrombolysis (group P) and 15 patients underwent stent implantation thrombolysis (group S). Endovascular treatment was performed with Digital substraction angiography. In brief, microcatheter was placed in the proximity of thrombus through 6-French guide catheter. Urokinase (100,000 U) was infused via microcatheter with additional injection (10,000 U/min) until the artery got recanalization or the total amount of urokinase reached 800,000 U [3, 4]. Stent implantation was directly performed if the microguidewire could get across the lesion. Sometimes urokinase was administered in advance of stenting [4]. Aspirin and Clopidogrel were applied for 3–6 months and low molecular weight heparin was applied for 5 days after stenting. Satisfied recanalization was accepted when the intervened arteries got residual stenosis less than 30%, or TIMI (thrombolysis in myocardial ischemia) score ≥2 level after thrombolysis [5]. Reocclusion was defined when the recanalized arteries got ≥50% stenosis 24 h after operation. National Institutes of Health Stroke Scale (NIHSS) scores were assessed immediately after operation, at discharge, 1 and 3 months postoperation. NIHSS improving ≥4 points was considered as good clinical outcome [3]. For statistical analysis, the SPSS statistical package was used. Means and frequencies were compared using nonpaired t-test and Fisher’s exact test. The P < 0.05 was considered as significantly different. Baseline characteristics are presented in Table 1. The most common location of occlusion was MCA in both groups. The average time of hospitalization in group S was much shorter than that in group P (P = 0.03). Compared with group P, patients in group S got better recanalization with low average residual stenosis (18% vs. 44.2% P = 0.004). There were 73% patients in group S, whereas 37% in group P, got acceptable residual stenosis (≤30%) (P = 0.02), and 100% patients in group S acquired a ≥2 TIMI score compared to the 68% in group P (P = 0.02). Unsatisfied recanalization (residual stenosis >50%) was found in 13% patients in group S but in 32% patients in group P. (Figure 1, Table 1). The ratio of patients who displayed ≥4 increase of NIHSS score was 73% at discharge and 87% at 1 and 3 months after operation in group S, whereas in group P, this ratio was 37%, 47%, and 53% respectively. (P < 0.05 at discharge and 1 month postoperation) (Table 1). Intracranial hemorrhage occurred in two patients in group P and one patient in group S. The patient in group S died of cerebral hernia 3 days later. Two patients in group P survived with poor outcomes. Three of 7 patients (43%) in group P and 1 of 12