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Rare TBK1 variant may confer protection in an APOE*4+ family

Rare variants are hypothesized to contribute greatly to the “missing heritability” in AD. APOE*4 is the strongest genetic risk factor for late‐onset AD. As such, older, cognitively normal APOE*4 carriers may harbor rare protective variants. We prioritized candidate variants in families based on their segregation with protected APOE*4 carriers, genotyping rate, rarity, functional consequence, and presence in additional protected APOE*4 carriers.