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OC97: Ductal flow dynamics and right ventricular size are influenced by maternal ingestion of polyphenol‐rich common beverages in normal pregnancies

Objectives: We have already demonstrated that maternal consumption of beverages with high polyphenol compounds causes fetal ductal constriction, as a result of COX-2 and prostaglandin inhibition. This study tested the hypothesis that in normal pregnancies maternal ingestion of polyphenol-rich common beverages (MIPRB) interferes with fetal ductal flow velocities and with the size of the right ventricle. Methods: A prospective analysis of 140 third-trimester fetuses from normal mothers was carried out, determining systolic and diastolic ductal flow velocities (DFV) and right to left ventricular dimension ratio. Mean gestational age was 28.4 ± 3.1 weeks (range, 23–38 weeks). A questionnaire was applied about MIPRB during pregnancy (herbal teas, mate tea and grape derivatives). Results: The group of 100 fetuses whose mothers declared to have used herbal teas or grape juice derivatives showed higher mean systolic (0.96 ± 0.23 m/s) and diastolic (0.17 ± 0.05 m/s) DFV, as well as higher mean RV/LV ratio (1.23 ± 0.23) than the group of 40 fetuses whose mothers had not utilized these substances (mean systolic velocity: 0.61 ± 0.18 m/s, P 0.85 m/s (P 0.15 m/s (P 1.1 (P < 0.001, relative risk = 27.6; 95% CI, 3.96–192.01), independently of gestational age. Conclusions: Ductal flow velocities are higher and right ventricular to left ventricular dimension ratios are larger in fetuses exposed to maternal ingestion of polyphenol-rich substances than in those not exposed. It seems clear that the ductal flow response to consumption of polyphenols during pregnancy is not a categorical parameter, but rather a continuous dose-dependent variable.