{'fraction_non_alphanumeric': 0.05193075898801598, 'fraction_numerical': 0.02796271637816245, 'mean_word_length': 5.5064935064935066, 'pattern_counts': {'":': 0, '<': 6, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Association between Inflammatory Markers and the Outcome of Critically Ill COVID-19 Patients

Background: Coronavirus disease (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). It had emerged from Wuhan, China and has rapidly spread around the world. In critically ill patients, the mortality rates are significantly high. This study analyzed the various inflammatory markers and their association with patient mortality, thus helping to identify critically ill patients with a high possibility of worsening prognosis. Materials and Methods: In this multicenter, prospective study, 85 patients were included and were followed until either of two outcomes was achieved: patients were successfully discharged or patients expired at the ICU. Correlation between the patient outcome and inflammatory markers were analyzed. Cut-off values for patients with worse prognosis were speculated through ROC curve. Results: Significantly, mortality was associated with CRP (P<0.001), d-dimer (P<0.001)., LDH (P=0.001), IL-6(P<0.001), serum ferritin(P=0.001), procalcitonin (P<0.001)along with neutropenia (P<0.001) and lymphocytosis (P<0.001). Conclusion: With the following inflammatory markers such as CRP, d-dimer, LDH, IL-6, procalcitonin and serum ferritin, patients who have a worse prognosis can be identified among the critically ill patients at the ICU. Hence, close monitoring and early management of such patients can help improve their prognosis.