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Low somatomedin-C (Sm-C) concentrations measured by direct radioimmunoassay in patients with chronic renal failure.

Ten patients suffering from chronic renal failure and undergoing regular hemodialysis were tested immediately before and immediately after a 3-hour dialysis. Serum levels of immunoreactive Sm-C, estimated on unextracted non acidified serum at non equilibrium, were significantly lower than in normal controls and no consistent modifications were observed after dialysis.