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Sex, forced expiratory volume in 1 s decline, body weight change and C-reactive protein in COPD patients

To the Editors: 

We read with great interest the study by Bridevaux et al. 1 about the possible sex role in weight gain and faster forced expiratory volume in 1 s (FEV1) decline as predictors of systemic inflammation (measured by C-reactive protein (CRP) levels) in chronic obstructive pulmonary disease (COPD) patients. Although the article is interesting, we found some conflicting methodological aspects that we wanted to highlight.

First, the authors state that females with COPD have a worse prognosis than males, based on the only study that supports this statement in the literature. Indeed, there is a body of literature indicating that females with COPD have …