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Enhancement of murine macrophage binding of and response to bacterial lipopolysaccharide (LPS) by LPS‐binding protein

We have studied the effects of highly purified rabbit lipopolysaccharide (LPS)‐binding protein (LBP) on the ability of murine bone marrow‐derived macrophages to respond to bacterial LPS. Macrophage responses studied include the secretion of tumor necrosis factorα, production of arginine‐derived nitrite (NO2−), and killing of an intracellular pathogen, Leishmania enriettii. Macrophages from either CBA or LPS‐hyporesponsive C3H/HeJ mice exhibited significantly greater sensitivity to LPS in the presence of LBP Furthermore, both CBA and C3H/HeJ macrophages demonstrated an LBP‐depen‐ dent enhancement of LPS binding. These results suggest that C3H/HeJ macrophages are capable of binding LPS‐ LBP complexes and support the hypothesis that hypo‐ responsiveness in this strain involves a step subsequent to LPS binding. Furthermore, these findings provide additional evidence of the important role played by the acute‐ phase plasma protein LBP in modifying host response to LPS.