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Impact of daily vinegar consumption on body composition and insulin sensitivity in overweight, healthy adults

Vinegar has been used as a folk medicine for years. Multiple studies in humans have shown an acute effect of preprandial vinegar consumption on attenuation of postprandial blood glucose and insulin concentrations, yet the chronic effect of daily vinegar consumption has not been examined. We examined the chronic effect of daily vinegar consumption on body composition and insulin sensitivity. Healthy, overweight subjects [n=8 (4 completed) vinegar (VIN) group; n=8 (5 completed) placebo (cranberry juice) group] consumed either 2 tablespoons (Tbsp) red raspberry vinegar or 1.5 Tbsp 100% cranberry juice 3 times per day before meals for 8 weeks. Body composition indices were measured at weeks 0, 2, 4, 6 and 8. Blood parameters and blood pressure were measured at weeks 0, 4, and 8. 27 subjects were initially stratified into the VIN or placebo group and matched on age, body mass index (BMI), body weight, fasting glucose, fasting lipid panel and blood pressure. Due to the drop outs, there was a significant difference at baseline in BMI [29.3 +/− 1.4 kg/m2 (mean +/− SEM) VIN vs. 36.4 +/− 1.8 kg/m2 placebo; p=.009], total cholesterol (206.9 +/− 7.8 mg/dL VIN vs. 179.4 +/− 5.3 mg/dL placebo; p=.009), and low density lipoprotein (132.0 +/− 8.1 mg/dL VIN vs. 110.3 +/− 5.0 mg/dL placebo; p=.032) in the subjects remaining. Data on the 9 completed subjects were analyzed adjusting for baseline BMI and no significant difference was found between the groups. Data collection is continuing but to date chronic vinegar consumption is not influencing body composition or insulin sensitivity parameters.