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n-6 and n-3 Essential fatty acids in rheumatoid arthritis and other rheumatic conditions

The essential fatty acids (EFA) have unique roles as precur- sor molecules of chemical regulators of inflammatory and immune cell function (Belch, 1989). These are the leukotrienes (LT) and the prostaglandins (PG). These com- pounds are synthesized and released by almost every tissue in the body, and participate in many biological functions, including the inflammatory and immune processes. Most work has focused on arachidonic acid, the precursor of the 2-series PG and the 4-series LT. Altering the EFA content in the diet or administering different EFA as supplements can modify the production of the various PG and LT by altering the substrate EFA. For example, the ingestion of a diet rich in borage