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Factors affecting Survival in Glioblastoma: A 10-year Single-Center Experience from Saudi Arabia.

BACKGROUND
Glioblastoma is one of the most common and aggressive brain tumors in adults, which is associated with poor survival rate. This study aims to identify the clinical characteristics and outcome of glioblastoma patients who underwent different treatment modalities and to determine the predictors of survival in them.


METHODS
A retrospective chart review conducted at King Abdulaziz University Hospital (KAUH). All patients diagnosed histopathologically with glioblastoma, treated between January 2005 and December 2015, were included. The overall survival rate was calculated using the Kaplan-Mayer method. A univariate analysis was carried out using a log-rank test, and the chi-square test was utilized for categorical data.


RESULTS
Thirty-seven patients were included in this study. Age ranged from 5-88 years. 54.1% of the included population were female. Based on immediate postoperative MRI studies, gross total resection was achieved in 40.5%, subtotal resection in 37.8%, and 21.6% underwent biopsy. The majority of patients received adjuvant radiotherapy (56.8%), while 32.5% received adjuvant chemotherapy. The median overall survival was 8.27 months.


CONCLUSION
Obtained results are consistent with international published reports. Factors that were associated with poor survival were age <50 years, presenting with signs and symptoms of increased intracranial pressure, postoperative KPS >50, and undergoing biopsy.