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Antidepressant drugs and experimental inflammation.

There are strong indications from this brief survey that the anti-inflammatory action of antidepressant drugs is involved in their well documented analgesic effect. In particular, the experimental data reported here contribute to explain the reduction of pain observed after the acute administration of antidepressants in clinical conditions. A better understanding of the mechanisms underlined should lead to improved therapies for pain, and to new compounds for the treatment of inflammation.