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Functional study and transcriptomic signatures confirm an application of induced microglia cellular model for studying Alzheimer’s disease

Microglia are specialized immune cells of the brain that maintains brain homeostasis. Amyloid protein accumulation due to inefficient microglial phagocytosis or neuroinflammation due to microglia polarization has been linked to Alzheimers disease (AD) progression. However, the lack of human microglia or microglial cellular model makes it difficult to understand the exact microglial functions underlying the disease.