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AB1026 Clinical characteristics and risk factors for gout attack during the postsurgical period

Objectives To evaluate the clinical features and risk factors for gout attack during the postsurgical period in patients with gout. Methods Seventy patients who had histories of gout and had been consulted to rheumatologic clinic before surgery under general anaesthesia at a single tertiary hospital were included. Clinical characteristics of patients who developed postsurgical gout attack were compared with patients who did not developed gout attack. Results Among 70 patients, 31 (44.3%) patients developed gout attack during postsurgical period. Mean time of gout attack after surgery was 3.7±4.9 days. Most of attacks involved lower extremity joints (83.9%) and tended to monoarticular involvement (61.3%). Knee joint (26%) and foot except 1st metatarsophalangeal (MTP) joint (26%) were more frequently involved than 1st MTP joint (13%). Uric acid levels before surgery (OR 1.46, 95% CI 1.13–1.88, p=0.004) and amount of uric acid changes between before and after surgery (OR 1.62, 95% CI 1.21–2.18, p=0.001) were risk factors for postsurgical gout attack. Taking medications for gout including uric acid lowering agents and/or colchicine reduced the risk of postsurgical gout attack (OR 0.11, 95% CI 0.04–0.32, p<0.001). Operation time, amount of blood loss during surgery, amount of fluid administration during surgery, and surgery site were not significantly associated with postsurgical gout attack. Conclusions Adequate uric acid control and taking medications for gout could prevent the postsurgical gout attack. Disclosure of Interest None declared