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Use of a controlled release drug as a bolus in cows

The article presents the results of using a drug with a controlled long-term release of a substance in a bolus form, which was administered orally to lactating cows with a predisposition to the development of metabolic disorders - first of all, the development of ketosis. As a result of the work, it was determined that in the experimental group of animals there was an unreliable increase in the concentration of total protein in the blood serum, while it should be noted that the phenomenon of the % ratio of albumin and globulins was impaired in animals of both groups. Also, in the experimental group of cows, the concentration of urea increased by 22%, which indicates the activation of protein metabolism, the cholesterol level in cows of both experimental groups increased. An analysis of the changes in lipids showed that the cholesterol concentration in the control group of cows by the 30th day of the experiment became 15% higher, and in the experimental group of animals - 27.9% higher, while the intergroup difference between them was 12.7%. The levels of triglycerides in animals of both groups were approximately the same and did not have significant differences, although their concentration slightly increased. The data obtained may indicate that under the action of boluses with prolonged release of components, there is a faster activation of metabolic processes in the body of cows in the postpartum period.