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Mechanisms of Reactive Oxygen Species‐induced Skin Erythema and Superoxide Dismutase Activities in Guinea Pigs

Reactive oxygen species (ROS)‐induced skin erythema was produced by injection of xanthine oxidase (XOD) and hypoxanthine (HPX), an ROS‐producing system, into guinea pig skin. The clinical course of the erythema was examined in relationship to the age of the animal as well as to superoxide dismutase (SOD) activity of the skin. The ROS‐induced skin erythema reached a peak 24 hr after injection of XOD and HPX macroscopically and histologically with the reduction of skin SOD activity, and the severity of erythema was age‐dependent. The increased severity of the skin erythema with age was related to the reduction of the skin SOD activities after XOD plus HPX injection. This skin erythema will provide a good model for the investigation of oxidative tissue injuries observed in several skin disorders.