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P2-217 Trends in incidence and case-fatality of acute myocardial infarction in Chile, 2001–2007

Introduction In Chile, coronary heart disease is the main cause of death in men and the second in women. Acute Myocardial Infarction (AMI) causes 73.6% of coronary heart disease deaths registered in Chile and its incidence is unknown. Aim: to estimate incidence and case-fatality of AMI in Chile and analyse their trends between 2001 and 2007. Methods All cases of AMI (according to the ICD-10, I21 code), registered in the National Hospitalisations and Death databases, were analysed. Annual incidence rates and case-fatality by sex and age groups were calculated. Direct method was used to standardise rates by age, using the WHO 2000 Population. Prais-Winsten regression models were used to evaluate trends, expressed as relative change. Results Between 2001 and 2007 we estimated that 83 754 cases of AMI occurred. Standardised mean annual incidence rate was 74.4 per 100 000 inhabitants (98.0 in men and 51.0 in women). Incidence rates increased by 35% in the age group <45 years and 9.2% in the group of 55–64 years (p<0.001, both). Total case fatality was 49.5% (45.4% in men vs 57.2% in women; p<0.001). Trend analysis showed a significant annual reduction of 1.2% in men and 0.81% in women. In-hospital case fatality was 14.2%, higher in women (11.3% vs 20.4% p<0.001); annual reduction was 0.57% in men and 1.01% in women (p<0.05 both). Conclusion AMI incidence was stable, although in younger age groups it increased. Case-fatality decreased both total and in-hospital. Despite the greater reduction in women, they still have a higher risk of in-hospital case-fatality.