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Kinetics of the Elimination and Neuromuscular Blocking Effect of d-Tubocurarine in Man

A pharmacokinetic model for the distribution and elimination of d-tubocurarine in man has been evolved from plasma concentration and urinary excretion data reported previously. This model represents the body as a three-compartment linear system, with the site of action of d-tubocurarinc being located in the central compartment on the basis of available knowledge of pharmacologic effects. Relationships between dose and duration of action and between dose and durations of effects of successive fractional doses administered after a constant initial dose have been predicted by the mathematical model and are in excellent agreement with experimental results. Additional simulations have been carried out to explore the effects of other dosage regimens of clinical interest for which experimental data are not presently available.