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Electrochemical Study of Sensor with Aptamer Specific to Glioblastoma

An aptasensor consisting of a gold disc electrode and aptamer Gli-233 specific to glioblastoma was prepared with different methods and studied by electrochemical and microscopic methods. It was found, that the real electro active surface area and electric double layer capacitance changed with the electrode modification. The highest capacitance was registered for the electrode modified with the simultaneous immobilization of Gli-233 and additional blocking agent (mercaptoethanol). It was shown that to develop an impedimetric sensor on the basis of Gli-233, it is necessary to optimize the conditions for the signal registration.