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Effect of exercise training on ischemia‐reperfusion injury of steatotic livers from OLETF ratsι

Exercise training is recommended to prevent the obesity‐associated disorders. However, it remains unknown whether exercise training attenuates ischemia‐reperfusion (I/R) injury of steatotic liver. We determined, using the hyperphagic, Otsuka Long‐Evans Tokushima Fatty (OLETF) rat and the control Long‐Evans Tokushima Otsuka (LETO) rat, effects of exercise training on I/R injury in perfused steatotic liver. Running training was given on a motorized treadmill for five weeks from 19‐th week. Livers from male exercise OLETF, exercise LETO, non‐exercise OLETF and non‐exercise LETO rats were perfused portally with diluted blood at a constant blood flow. Ischemia was induced by occlusion of the portal vein for 1 hour, followed by 1‐hour reperfusion in a recirculating manner. Liver injury was assessed by blood alanine aminotransferase (ALT) levels, bile flow rate and histology of the livers. I/R‐induced increase in blood ALT levels of OLETF rats was higher than that of LETO rats. Exercise training attenuated the increase in both body weight and liver weight, and liver cell degeneration in OLETF rats, as compared the corresponding non‐exercise OLETF rats. I/R‐induced ALT elevation tended to be smaller in exercise OLETF rats than in non‐exercise OLETF rats. Reduced bile flow rate were similar among rats studied. In conclusion, exercise training produces a marginal effect on I/R injury of steatotic livers from OLETF rats.