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Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK‐1 and TASK‐3 channels in mouse carotid body type‐1 cells

•  TASK‐like background potassium channels play a key role in the sensing of hypoxic, metabolic and acidic stimuli in arterial chemoreceptor cells. •  In this study, we investigated the roles of TASK‐1 and TASK‐3 in forming these channels by using gene deletion in mice. •  Deletion of Task‐1 (Kcnk3) and/or Task‐3 (Kcnk9) disrupted the main form of background K‐channel activity. •  In single knock‐out mice, we observed, instead of the wild‐type channel, the homomeric forms of TASK‐1 in Task‐3−/− and TASK‐3 in Task‐1−/−. •  All forms of TASK were inhibited by hypoxia, cyanide and the uncoupler FCCP. •  We conclude that the main form of background K‐channel in chemoreceptor cells is a TASK‐1/TASK‐3 heterodimer and that both TASK‐1 and TASK‐3 subunits can couple to both oxygen and metabolic signalling pathways in these cells.