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Genetics of substance use disorders

The literature on the existing evidence for a genetic component is reviewed for substance use disorders (SUD), formerly known as substance abuse and substance dependence. The chapter provides a historical perspective of the evolution of genetic understanding in the field. It also discusses the most recent methods of studying genetic factors in SUD, as well as the related discoveries of genes involved in SUD. It concludes on the possible role of genetics in the evolution of the concept and the mechanisms of SUD.