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Mechanistic analysis of bladder cancer suppression by brassicasterol in a rat model of N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine‐induced bladder cancer

We previously clarified that the herbal medicine Polyporus Sclerotium, a constituent of Choreito, has an inhibitory effect on bladder carcinogenesis and that ergosterol is the active ingredient. In addition, we showed that this action of ergosterol may be caused by the metabolite brassicasterol. Here, we aimed to elucidate the detailed molecular mechanism by which brassicasterol inhibits bladder carcinogenesis.