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Novel regulation of death‐associated protein kinase 1 in Alzheimer’s disease

Death‐associated protein kinase 1 (DAPK1) is a serine/threonine kinase that plays an important role in regulating neuronal function and is genetically linked to Alzheimer’s disease (AD). We previously showed that DAPK1 expression is markedly increased in 75% of human AD brains. Moreover, we found that DAPK1 promotes tau protein accumulation and its phosphorylation at multiple AD‐related sites. However, it is not known whether and how DAPK1 expression or activity is regulated in AD, including tau hyperphosphorylation and functions.