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Triple positive tumor markers predict recurrence and survival in early stage hepatocellular carcinoma

Hepatectomy is feasible for patients with hepatocellular carcinoma (HCC) with good hepatic function who meet the Milan criteria. Several studies have indicated that tumor markers of HCC, α‐fetoprotein (AFP), Lens culinaris agglutinin‐reactive fraction of AFP percentage and protein induced by vitamin K absence/antagonist‐II were good predictors of malignant potential. It is important to identify highly malignant cases of HCC, and the aim of this study was to clarify the impact of triple positive tumor markers as the prognostic factors for early stage HCC within the Milan criteria.