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Influence of Adjuvant Chemotherapy on Skeletal Muscle and Fatigue in Women with Breast Cancer

The purpose of this pilot study was to investigate the changes in skeletal muscle size and strength and perception of fatigue in women undergoing adjuvant chemotherapy for breast cancer. The findings of this pilot study suggest that changes in muscle size and strength can occur during chemotherapy. Quadricep muscle size increased for two subjects. These subjects also experienced an increase in muscle strength. This is the first known study to address change in muscle size and fatigue in women during adjuvant chemotherapy for breast cancer from an integrated biobehavioral perspective. Our findings may indicate that muscle size can increase during chemotherapy, but this may not diminish the subjective experiences of fatigue. As the potential for causing serious damage to striated muscle exists, further research into muscle changes and activity during chemotherapy and its role in fatigue is crucial.