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Anti-Th/To antibodies in Italian scleroderma patients: clinical and immunological correlations and comparison with patients with anti-centromere antibodies

Anti-Th/To antibodies, found in 3–5% of patients with systemic sclerosis (SSc), recognise a nucleolar 7–2/8–2 RNA-protein complex. They are associated with limited SSc (lSSc) with lung involvement and reduced survival comparing with anticentromere (ACA) (+) patients. However, clinical studies on anti-Th/To are limited due to poor availability of serological tests. The aim of our study is to compare the clinical manifestations of …