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Prostate Cancer SubtyPINg BiomarKers and Outcome: Is Clarity EmERGing?

Molecular prostate cancer subtypes have been proposed on the basis of mutually exclusive SPINK1 and ERG overexpression, with conflicting reports on their prognostic ability. Flavin and colleagues report that SPINK1 is neither prognostic nor absolutely mutually exclusive with ERG, raising important questions about prostate cancer molecular subtyping and prognostic biomarker evaluation. Clin Cancer Res; 20(18); 4733–6. ©2014 AACR.