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EVALUATION OF SKIN PATCH TESTS USING SUMP METHOD

The potential to cause a primary irritant reaction is usually evaluated by clinically recognizable dermatitis at the site of patch testing. Such evaluation is difficult in the case of substances with low irritancy potential which sometimes fail to cause grossly visible signs of dermatitis. In those cases a higher concentration of the test substance may be used in order to produce a visible reaction, but such concentrations may lead to unnecessary irritation and are of little value in determining the safety of the substance in concentrations of practical use.