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Clones with 5q - and inversion of chromosome 7 in PHA stimulated peripheral blood.

In a patient with autoimmune thrombocytopenic purpura, 2 distinct clonal abnormalities, deletion 5q and inversion 7, could be demonstrated in phytohaemagglutin stimulated peripheral blood. A large number of bone marrow mitosis was normal while unstimulated peripheral blood revealed no metaphases. The mutational events leading to the aberrations might have taken place in lymphoid precursor cells or in a pluripotential stem cell that lost the capacity to develop in the myeloid direction.