{'fraction_non_alphanumeric': 0.0472027972027972, 'fraction_numerical': 0.011072261072261072, 'mean_word_length': 5.52851711026616, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
ALTERED SERUM MARKER OF THYROID PROFILE AND ANTIOXIDANT ENZYMES IN INDIVIDUALS ALZHEIMER'S DISEASE

Thyroid dysfunction and oxidative stress are incriminated to play a central role in the pathological processes that lead to neuronal degeneration in patients with Alzheimer’s disease (AD).This research study was mainly concerned with observing the changes in serum biochemical parameters including thyroid hormone (tri-iodothyronine (T3) and thyroxine (T4), thyroid-stimulating hormone(TSH), and antioxidants enzymes (glutathione peroxidase (GSH-Px), CAT(catalase), superoxide dismutase (SOD), total antioxidant status(TAS), and Glucose-6-phosphate dehydrogenase (G6PD)) in the serum samples of the in patients with AD (n=54) and compared with control subjects (n=54). Results: The statistical significance was evaluated by Student’s t-test, Correlation-Coefficient test. All Values are given as mean ± SD. Serum T3, T4, TAS, GSH, SOD, G6PD, and catalase levels were decreased, whereas serum TSH, and MDA levels were increased in the study group compared to controls though statistically significant (P ˂ 0.05). TSH showed a significant positive correlation with T4, MDA, Cat, and TAS, whereas inverse correlation with T3, G6PD, SOD, GSH, and GPx in AD patients. Conclusions: it could be suggested that increased TSH, whereas decreased T3, and T4 has a role in AD development and oxidative stress may exacerbate the condition. Oxidative stress as one of the risk factors, which can initiate and/or promote neurodegeneration in AD and was correlated to the severity of the disease. Therefore, further prospective studies with larger number of patients are required to strengthen the observations of the present study.