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[The quantitative passage of immunoglobulins from the intestine into the blood vessels in newborn lambs].

A trial with 69 lambs examined the effect of the feeding regime on the transfer of colostral immunoglobulins from the intestinal lumen to the circulating blood. The lambs received 125 ml of bovine colostral milk per kg birth weight at each feeding in the first 24 hours after birth. There were four experimental groups. Feeding intervals were either 2 or 6 hours and the milk was administered with or without doubling the fluid volume by addition of tap water. Serum concentrations of IgG1, IgG2, IgM and IgA were measured during the experimental period and the transport efficiency index for each isotype was calculated. The transport efficiency index represents the relationship between the amount of immunoglobulin administered in colostral milk and the concentration measured in the blood. Feeding in 2 hour intervals produced maximum immunoglobulin concentrations at 30 hours, while 6 hour feeding intervals achieved the same maximal levels at 24 hours. The relative proportions of the four immunoglobulin isotypes measured in the blood were unaffected by the feeding interval. Doubling the fluid volume administered while holding the absolute amount of colostral milk constant, resulted in a disproportionate increase in blood IgG1 concentration as compared to the other isotypes. Concentrations for IgG2, IgM and IgA remained essentially the same as those achieved with undiluted colostral milk. The feeding regimes tested did not affect endogenous immunoglobulin synthesis, growth rate or the health of the lambs.