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EP1141 Reproductive outcomes after treatment of patients with gestational trophoblastic neoplasia

Introduction/Background To assess reproductive outcomes including menstrual and fertility function of gestational trophoblastic neoplasia (GTN) patients after treatment. Methodology Patients with GTN who had clinical data in our institution present were identified. Data collected were age at GTN diagnosis, menstrual and obstetrical history, characteristics of GTN, treatment and reproductive outcomes including menstrual and fertility function after treatment. Results From 115 GTN patients, 73 patients had available data and were included in the study. Median age at GTN diagnosis was 32.8 years (range, 17–52 years), with 75.7% aged ≤ 40 years and 97.3% ≤ 50 years. Clinico-pathological data of the patients were presented elsewhere. In brief, 74.3% had FIGO stage I disease and 85.1% were classified as low risk by WHO scoring system. Total hysterectomy was performed in 20.3% (or 21.6% including one patient who had hysterectomy prior to GTN diagnosis): prior to or after few cycles of chemotherapy were performed in 12.2% and 8.1% respectively. Median age of the patients who had or did not have hysterectomy were 41.2 years (range, 27–52 years) vs 31.4 years (range, 17–50 years) respectively (p<0.001). Among 59 patients who did not undergo hysterectomy, all except one had chemotherapy. Methotrexate and actinomycin-D were the most common first-and second-line chemotherapy, 74.1% and 80.0% respectively. Menstrual history was uncertain in almost all patients. Total of 27.0% of all patients or 34.5% of patients who had preserved uterus achieved pregnancy at least once with the median interval time of 44.0 months (range, 2.7–97.3 months) after complete treatment. Conclusion Approximately 76% of GTN patients aged 40 years or younger. Majority were in early stage and low risk. Nearly 35% of the patients who did not have hysterectomy could have at least 1 pregnancy after treatment with chemotherapy. Disclosure Nothing to disclose