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Uptake of 3H-progesterone by brain and pituitary of castrated male rats.

Gonadectomized male rats of Wistar strain were administered 3H-progesterone. Various brain tissues and anterior pituitary were analyzed for retention of radioactivity, using a liquid scintillation technique. Radioactivity, in all tissues, was highest at 20 min after steroid treatment, and thereafter dropped nearly in the same pattern as each other. Among the tissues examined median eminence and anterior pituitary retained more radioactivity for a longer period of time than did other tissues. The results suggest that there is long-term retention of progesterone in the median eminence and anterior pituitary of male rats.