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Immunogenetics of Autoimmune Diseases in Asian Indians

Abstract: The HLA class II molecules play a critical role in the processing and presentation of specific peptides derived from autoantigens of pancreatic beta cells or gluten for T cell scrutiny in IDDM and CD. In the present study, extended DR3‐positive haplotypes associated with autoimmunity in northern Indian patients have been reported. The haplotype A26‐B8‐DR3 was the most common autoimmunity‐favoring haplotype encountered among these patients. This association is, indeed, unique to Indian autoimmune patients, as it replaces the otherwise most commonly associated Caucasian haplotype A1‐B8‐DR3 (AH8.1) in this population. Further, CD patients revealed 100% association with DQB1*0201 along with DQA*0501 (97%) either in cis or trans configuration.