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Cytomorphology of myxoid liposarcoma of thigh

Myxoid liposarcoma variant of liposarcoma which constitutes around 15% to 20% to one-fourth of all liposarcoma (LPS). 1 They are most commonly seen in the thigh in the deeper soft tissue with rare cases found in the foot (1.3% – 2.7%) or leg (6.7% – 13.5%). 2 The male to female ratio is 1.1:1 with age ranging between 17 and 76 years and a mean age of 52 years. The size ranges between 2 and 32 cm (mean: 9.7 cm). 1 As per the recent WHO 2020 there are five types of liposarcomas namely well-differentiated, myxoid, round cells, pleomorphic and the newly introduced myxoid pleomorphic liposarcoma. 1 – 3 They present as a rapidly enlarging, painless mass; 30% of patients may have dull aching pain or tenderness with few giving a history of trauma in the affected area. 1 There is no specific diagnostic finding on MRI and it may mimic a ganglion cyst at times. Soft-tissue sarcomas are generally restricted to one