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Antihyperglycemic and antioxidant activities of Nopal (Opuntia ficus indica) in patients with type 2 diabetes

Nopal (Opuntia ficus indica), a Mexican variety of cactus is widely used as a food and as a popular treatment for type 2 diabetes (T2D). Thus, the aim of this work was to evaluate whether the consumption of 300 g of steam nopal in a high carbohydrate breakfast (HCB) or in a high soy protein breakfast (HSPB) modified blood glucose, serum insulin, plasma GIP, GLP‐1 and antioxidant activity in plasma of patients with T2D. Fourteen patients with T2D, aged 48.7 ± 2.1 y, with a BMI of 28.99 ± 1.0 kg/m2 were recruited. Blood samples were drawn before and 15, 30, 45, 60, 90, 120,150 min following breakfast tests. HPB was significantly more effective to regulate the postprandial glucose regardless of the presence of nopal, however the combination of HPB+nopal was more effective to control GIP and showed more postprandial antioxidant activity than just the HPB. These results suggest that nopal in combination with soy protein is an effective antioxidant to reduce reactive oxygen species (ROS) and also is an antihyperglycemic food to control postprandial glucose in patients with T2D. Supported by Grupo Produce México (to NT, 2010)