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Expression and significance of vimentin in the epithelial layer of senile cataract

Objective:To clarify the effect of abnormal expression of vimentin on the formation of senile cataract.Methods:The expression of vimentin was assayed using immunohistochemistry(S P) in the epithelial layer of 31 cortical cataracts,20 nuclear cataracts and five normal lenses.Results:The expression of vimentin in the epithelial layer of cortical cataracts was significantly higher than in the epithelial layers of both nuclear cataracts and normal lenses(P0.01).Conclusion:Senile cortical and nuclear cataract possess a different pathogenesis. The development of cortical cataracts is correlated with over expression of vimentin.