{'fraction_non_alphanumeric': 0.026119625499433478, 'fraction_numerical': 0.010376289581966725, 'mean_word_length': 5.204217536071032, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 2, 'https://': 1, 'lorem ipsum': 0, 'www.': 1, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Deep gluteal syndrome

Deep gluteal syndrome describes the presence of pain in the buttock caused from non-discogenic and extrapelvic entrapment of the sciatic nerve. Several structures can be involved in sciatic nerve entrapment within the gluteal space. A comprehensive history and physical examination can orientate the specific site where the sciatic nerve is entrapped, as well as several radiological signs that support the suspected diagnosis. Failure to identify the cause of pain in a timely manner can increase pain perception, and affect mental control, patient hope and consequently quality of life. This review presents a comprehensive approach to the patient with deep gluteal syndrome in order to improve the understanding of posterior hip anatomy, nerve kinematics, clinical manifestations, imaging findings, differential diagnosis and treatment considerations.


INTRODUCTION
The progress in understanding posterior hip anatomy and sciatic nerve kinematics has helped to identify several locations where the sciatic nerve can be entrapped. For that reason the term 'deep gluteal syndrome' instead of 'piriformis syndrome' is now preferred to describe the presence of pain in the buttock caused from non-discogenic and extrapelvic entrapment of the sciatic nerve [1]. The structures that can be involved in sciatic nerve entrapment within gluteal space include the piriformis muscle [2,3], fibrous bands containing blood vessels, gluteal muscles [4], hamstring muscles [5,6], the gemelli-obturator internus complex [7,8], vascular abnormalities [9,10] and spaceoccupying lesions [11]. There are some unique factors in the history and physical examination that can define the specific site where the sciatic nerve is entrapped. A comprehensive assessment of the hip will help to recognize the specific problem in each individual case. Failure to identify the cause of pain in a timely manner can increase pain perception, and affect mental control, patient hope and consequently quality of life. This review presents a comprehensive approach to the patient with deep gluteal syndrome in order to improve the understanding of posterior hip anatomy, nerve kinematics, clinical manifestations and treatment considerations as well as the differential diagnoses like pudendal nerve entrapment, ischiofemoral impingement, greater trochanter ischial impingement and ischial tunnel syndrome.
The anatomy of the deep gluteal space is unique in that the nerve enter the pelvis through the sciatic notch and it has a significant mobility with hip movements as described by Coppieters et al. [12]. They found that the sciatic nerve has 28 mm of excursion during hip flexion. However, this motion is affected by anatomic variances between the sciatic nerve and the piriformis muscle in 16.2% of the population as reported by Smoll et al. [13].
Considering that a neuropraxia can be produced at 6% strain, and that a complete block can occur at 12% strain [14], the nerve kinematics is a crucial aspect of the entrapment's pathophysiology. To date, the kinematics of the sciatic nerve continues to be explored. It has been reported that in deep flexion, abduction and external rotation of the hip, the sciatic nerve glide across the posterior border of the greater trochanter. Additionally, in the full flexed, abducted externally rotated state, the semimembranosus origin and the posterior edge of the greater trochanter can come into contact [15]. Excursion of the nerve is dependent upon the flexion of the knee. When the knee is flexed, the nerve moves posterolateral and when the knee is extended the nerve moves deep into the tunnel [15].

History
The diagnosis of deep gluteal syndrome is based upon a comprehensive history and physical examination of the hip (see video on Youtube V R https://www.youtube.com/ watch?v¼IhvVoKGyl8E).
The lumbar spine plays an important role in hip pain. Hence, a differentiation of problems coming from the spine should be performed during the history and physical examination. Once the lumbar pathology is ruled out using specific tests and spine imaging, the physical examination should be directed toward the deep gluteal space as a cause of posterior pain.
Patients with sciatic nerve entrapment often have previous history of trauma and symptoms of sit pain, radicular pain of the lower back or hip and paresthesias of the affected leg [4,16]. Patients may present with neurological symptoms of abnormal reflexes or motor weakness [17]. Some symptoms may mimic a hamstring tear or intraarticular hip pathology such as aching, burning sensation or cramping in the buttock or posterior thigh.
The factors or positions that increase or decrease the pain can dictate the diagnostic approach. A sitting pain is usually associated with sciatic entrapment beneath the piriformis muscle. A walking pain lateral to the ischium is associated with ischiofemoral impingement, in which the lesser trochanter rubs the lateral border of the ischium [18].
Filler et al. [3] originally described the sources of nondiscogenic sciatic nerve entrapment in 239 patients, and the most common sites were beneath the piriformis muscle (67.8%), sciatic foramen (6%), ischial tunnel (4.7%), followed by the additional sources as seen in Table I.
Posterior hip pain could originate from intrapelvic problems, hence a focused urologic and gynecologic history should be addressed in order to detect any suggestive sign of intrapelvic entrapment such as cyclic variations in pain [19]. High resolution imaging of the pelvis or abdomen assists in identifying any type of endometrioma or vascular entrapment of the sciatic nerve in the intra-abdominal region.
Posterior hip pain commonly presents in a chronic fashion significantly affecting the quality of life. Therefore, a psychological evaluation before any treatment is recommended for patients complaining of chronic pain >6 months, who are using narcotics, and have a significantly impaired social function. Psychological strategies for diagnosing depression and anxiety disorders related with chronic pain have shown high specificity and reliability [20]. These factors could affect the outcomes and the satisfaction of the patient and the surgeon.

Specific tests on physical examination
A five-level examination is mandatory in the diagnosis of complex disorders of the hip. The examination will adequately assess the osseous (level 1), capsulolabral (level 2), musculotendinous (level 3), neurovascular (level 4) and kinematic chain (level 5) helping to direct appropriate tests and treatment modalities [21].
A common language and technique on physical examination should be used [22]. Patients presenting with chronic  (1) as it enters the pelvis at the sciatic notch anterior to the piriformis muscle (2) and sacrotuberous ligament (3). As the nerve courses distally toward the ischium and hamstring origin (4) it passes posterior to the gemelli-obturator internus complex (5) and quadratrus femoris (6, with the inferior portion removed to expose the lesser trochanter). Lateral structures include the lesser trochanter (7) and greater trochanter (8).
pain should have a systematic exam to ensure that important causes of posterior hip pain are not overlooked.
Some specific tests are especially helpful when evaluating a patient with posterior hip pain. The seated piriformis stretch test (Fig. 2) is a passive flexion, adduction with internal rotation test performed as the examiner palpates the deep gluteal region. The active piriformis test (Fig. 3) is an active abduction and external rotation test while the examiner monitors the piriformis. The combination of the seated piriformis stretch test with the piriformis active test has shown a sensitivity of 91% and specificity of 80% for the endoscopic finding of sciatic nerve entrapment [23].
The palpation of the gluteal structures is fundamental for the diagnosis of gluteal pain. Using the ischial tuberosity as a reference, the production of pain by palpation can guide the probable source of symptoms as follows: at the sciatic notch, piriformis syndrome (Fig. 4A); lateral to the ischium, ischial tunnel syndrome or ischiofemoral impingement (Fig. 4B); and medial, pudendal nerve entrapment (Fig. 4C) [4]. The more important differential diagnoses when evaluating a patient with posterior hip pain are ischiofemoral impingement and ischial tunnel syndrome (also known as hamstring syndrome). In the first case, a provocative test should be performed with the patient in the contralateral decubitus position and taking the affected hip into passive   extension. The findings of this test are considered positive when the symptoms are reproduced in adduction or the neutral position, whereas extension with abduction does not reproduce the symptoms (Fig. 5A and B). During active hamstring test muscle strength shows marked weakness and pain at 30-degree knee flexion, whereas strength is normal and pain is improved at 90-degree knee flexion ( Fig. 6A and B). Differential diagnoses of deep gluteal pain are summarized in Table II.
Treatment Imaging guided intra-articular and extra-articular injections (local anesthetic and steroids) have been described to be very helpful, precise and reproducible for discriminating these complex pathologies [3]. Botulin toxin has been reported as an effective adjunt to physicial therapy in the treatment of piriformis syndrome [24], however in the experience of the senior author the botulin toxin produces more scar tissue around the sciatic nerve. The percentage  of relief after injection should be investigated in order to determine how much the injected site is contributing to the pain.
In rare cases that fail conservative therapy (including physical therapy, analgesic and anti-inflammatory drugs, and injections), surgical treatment (open or endoscopic) may be considered. Several studies have reported good results after open sciatic decompression in patients with piriformis syndrome [3], hamstring syndrome (also called ischial tunnel syndrome) [6], sciatic neuropathy associated   [25], post-traumatic sciatica [16], retro trochanteric pain syndrome [8] and other causes. In 2003, Dezawa et al. [26] reported the endoscopic decompression of the sciatic nerve entrapment as an effective and minimally invasive approach on six cases of piriformis syndrome. Martin et al. [4] reported a case series of 35 patients presenting with deep gluteal syndrome treated endoscopically. Average duration of symptoms was 3.7 years with an average pre-operative verbal analog score of 7, which decreased to 2.4 post-operatively. Pre-operative modified Harris Hip Score (mHHS) was 54.4 and increased to 78 post-operatively. Twenty-one patients reported preoperative use of narcotics for pain; 2 remained on narcotics post-operatively (unrelated to initial complaint). Eightythree percent of patients had no post-operative sciatic sit pain (inability to sit for >30 min). Five patients experienced low mHHS scores and modest pain relief post-operatively. This poor outcome group may be related to femoral retroversion and previous abdominal surgery. Pérez-Carro et al.

Endoscopic assessment and decompression technique
Endoscopy allows for a complete extrapelvic sciatic nerve visualization and safe nerve decompression in the deep gluteal space. The supine (or lateral) technique allows for manual manipulation of the lower limb at the knee and hip joints for the full assessment of sciatic nerve kinematics. A relative contra-indication for sciatic nerve decompression in this supine technique is knee recurvatum, considering the increased strain on the sciatic nerve. Nerve conduction and EMG is usually monitored intra-operatively and can demonstrate immediate improvement or change postrelease. Acute variations in nerve conduction during the course of surgery may be observed due to fluid accumulation over time. For deep gluteal space visualization, a 70degree high definition long arthroscope with adjustable and lengthening cannulas are utilized [4]. The cannulas are opened to maintain the fluid flow, when utilizing the radiofrequency probe [27]. Fluid pressure is set to 60 mmHg with intermittent pressure increases up 80 mmHg. Three portals are utilized: anterolateral, posterolateral, and an auxiliary posterolateral portal (Fig. 7). Frequent use of intra-operative fluoroscopy will confirm the proper location of the endoscopic view.  The inspection of the sciatic nerve should include the recognition of normal versus abnormal nerve appearance and motion ( Fig. 8A and B). A branch of the inferior gluteal artery must be identified and cauterized for access to the piriformis muscle. A cadaveric study has reported a mean distance of 8 mm (4-14 mm) between the sciatic nerve and the crossing branch of the inferior gluteal vessel [27]. Additionally, the temperature profile during activation of a monopolar radiofrequency device was found to be safe at a distance of 3-10 mm to the sciatic nerve during activation times of 3, 5 and 10 s [27]. The standard approach to vessel cauterization is a 3-s interval of radiofrequency activation, maintaining continuous irrigation.
A standardized technique and surgical experience for diagnosis and sciatic nerve decompression is mandatory in order to identify the sciatic nerve anatomy, avoid iatrogenic injury and to not overlook potential sources of sciatic nerve entrapment. A 10-step technique for safe sciatic nerve decompression is presented in Table III.   Post-operative rehabilitation The rehabilitation of these complex pathologies is critical for success. The purpose of rehabilitation is to gain mobility and maintain movement of the hip joint and avoid any type of stretching of the nerve that can produce neuralgia or neuropraxy. The complete rehabilitation process takes an average of 24 weeks to return to previous activity [28].
Full circumduction of the hip (engaging the greater trochanter on the ischium and pushing the sciatic nerve lateral) with knee flexion can begin on day one (Fig. 9). Piriformis stretch (Fig. 10) and nerve glides ( Fig. 11A and B) can be applied under the limit of pain. A knee brace is used to avoid knee extension and maintain a relaxed sciatic nerve during therapy. The utilization of the knee brace is dependent upon the strain of the sciatic nerve, which is influenced by the degree of femoral anteversion and the number of sites of entrapment. The knee is locked at 45 degree for 3 weeks applying only nerve glides and circumduction. After 4 weeks, knee extension can increase up to 10 degree every 2 weeks as tolerated. Increase range of motion for hip flexion and adduction can be carefully applied, gentle nerve glides and include stretching maneuvers aimed at the external rotators. Standard physical therapy protocol can begin as early as 6 weeks. Again, a word of caution in cases of previous abdominal surgery and femoral retroversion as strain parameters will be a dependent factor, and the nerve may be impinged in more than one location. The therapist should be diligent in recognizing these potential outcome factors. These physical therapy techniques are the same techniques used in pre-operative conservative treatment.
The use of steroidal and non-steroidal antiinflammatories has been found useful after day 2. Additional physical therapy techniques may be helpful including ultrasound and electrical stimulation. With a proper rehabilitation protocol, good to excellent outcomes can be achieved. The advancement in rehabilitation has proven beneficial to improve the outcomes of endoscopic sciatic nerve decompression.
At the present time, among 200 international cases have addressed extrapelvic deep gluteal syndrome and complications continue to be extremely low. To help avoid post-surgical stretch injury, it is recommended that intraarticular work be performed separately from extra-articular work. Due to the length of time from diagnosis to treatment and recovery, the psychological toll of the pain cycle can be frustrating. Complications have involved hematomas brought on by early post-operative use of NSAIDs with excessive post-operative activity. Concomitant pudendal nerve and sciatic nerve complaints are often resolved, however in two of those 200 cases the pudendal complaints worsened.

CONCLUSION
The understanding of deep gluteal syndrome continues to evolve with the recognition of the various sites that the sciatic nerve can be entrapped. A comprehensive history and physical examination with specialized testing including injections will aid in the differential diagnosis of posterior hip pain. Open or endoscopic decompression of the sciatic nerve in cases that fail conservative therapy are useful in improving function and diminishing pain.