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Atherosclerosis. Regression in nonhuman primates.

RESULTS of Anitschkow's early experiments (1927) suggesting that arterial lesions induced in rabbits by high cholesterol diets decrease in size and in fat content after cessation of cholesterol feeding have been confirmed in numerous species of animals, including rabbits, chickens, dogs, pigeons, pigs, and nonhuman primates (see references in Malinow, in press). This review deals with the studies performed in monkeys, their relevance to human atherosclerosis, and possible mechanisms of the observed arterial changes.