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Syphilis: A Rare Cause of Acute Hepatitis

Syphilis is a sexuality transmitted disease caused by Treponema pallidum. Its incidence has started to increase in the world, especially in hiv-infected patients. Liver involvement in syphilis is a very rare condition and usually occurs in the second phase of the disease where the brain, skin and genital organs are involved. This liver damage refered to syphilitic hepatitis generally is mild clinical condition that presents with disproportionately increased alkaline phosphatase and slightly high transaminase. Elevated liver enzymes levels are a common encountering problem in clinical practice. Generally diagosing the disease is very diffucult and time-consuming. A variety of diseases has been identified the etiology of the cause of this elevation. Secondary syphilis, rarely developed acute hepatitis is one of these diseases. Therefore, It should be included in the early differential diagnosis if the patients has liver dysfunction of uncertain etiology and high risk sexual behaviors.