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Lipophilicity prediction of 3 photosensitizers by liquid-liquid extraction, HPLC, and DFT methods.

Photodynamic therapy (PDT) is a method of treating precancerous diseases and malignant neoplasms. The efficacy of PDT depends on different parameters such as light dosimetry, oxygen availability, and photophysical and physical-chemical properties of the photosensitizer. In PDT, a photosensitizer is activated using light to promote oxygen photosensitization and cellular transport plays a key role in the reach of it the desired tissue. In particular, to know the effectiveness of the drug delivery in PDT and its dosage forms to target damaged organs, along with such characteristics as water solubility, it is important to know the ability of a substance to penetrate through cell membrane or accumulate in it. The lipophilicity is used to quantify the above-described abilities. We evaluated the lipophilicity of three selected PS protoporphyrin IX, pyropheophorbide-a and photofrin by means of three different methods: octanol-water distribution methods (Shake-flask), reversed-phase high-performance liquid chromatography (HPLC) and theoretical calculations based on density functional theory (DFT). We describe and compare the results of these various methods.