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Increased levels of eosinophil-derived PAF-acether activity in a patient with idiopathic hypereosinophilic syndrome.

We describe a patient with idiopathic hypereosinophilic syndrome (IHS) having PAF-acether activity corresponding to 4 X 10(-11) M/10(6) eosinophils as determined by standard aggregation curves prepared with purified PAF-acether. These data suggest that the increased PAF-acether content in patients with IHS may play a role in the development of thrombotic phenomena through platelet activation.