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Effects of N‐acetyl‐aspartyl glutamic acid and sodium cromoglycate on leukotriene B4 secretion by human leukocytes

Peripheral leukocytes from allergic subjects were treated for 30 min with sodium cromoglycate (SCG) or with N‐acetyl‐aspartyl glutamic acid (NAAGA) and challenged for leukotriene B4 (LTB4) production with calcium ionophore A 23187. NAAGA significantly inhibits LTB, release at concentrations of 10−2 M (−86%), 5.10−3 M (−49%) and 10−3 M (−34%), while SCG was not able to block LTB4 production within the range of 10−2–10−4 M. In spite of the fact that SCG and NAAGA are chemically unrelated and that both show antiallergic properties, only NAAGA is able in this model to block production of LTB4, a chemical mediator strongly involved in inflammatory and hypersensitivity reactions.