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Glucagon‐induced Growth Hormone Release in Infants

We have studied the usefulness of subcutaneous glucagon administration as an initial screening test for a deficiency of HGH in infants. Before and 60, 90, 120, 150, and 180 minutes after administration of glucagon (0.03 mg/kg), specimens of the venous blood were collected for determination of human growth hormone (HGH) . Eight of 16 healthy infants showed raised HGH levels more than 10 ng/ml at 0 time during the test. (FIG. I). Only 2 of 16 infants showed no significantly high HGH value at any time all through the test (FIG. 11). Blood samples were collected at 30-minute intervals for 90 minutes from 2 healthy infants injected