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Reused cyclodextrin as a new way to deliver and enhance drug loading onto ion exchange resin

Abstract Context: Cyclodextrins could improve drug solubility and drug loading onto ion exchange resins. Moreover, the remaining cyclodextrin in the solution might be reused for drug solubility enhancement and drug loading onto resin. Objectives: To investigate the application of fresh and reused cyclodextrin to improve drug solubility and drug loading onto resin. Methods: The inclusion complexes were prepared and characterized using β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPβCD). The drug solution was loaded onto resin with and without cyclodextrin. Then, the remaining cyclodextrin was reused for the complex and the drug loading process. Results and discussion: Improved drug solubility was observed when using cyclodextrins. The complex was successfully formed with 1:1 stoichiometry. The increase in drug solubility with cyclodextrins improved drug loading onto resin. The cyclodextrins delivered drug to bind with resin, forming resinate, and did not bind with the resinate themselves, which was confirmed by quantification of the amount of cyclodextrin in drug loading solution before and after drug loading process. Therefore, cyclodextrins were available to reuse for drug loading without affecting the percentage of drug loading. Conclusions: Reused cyclodextrin is a novel way to deliver and enhance drug loading onto resin for development of an ion exchange-based drug delivery system.