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Multidisciplinary management of adult anaplastic astrocytomas.

The management of patients with anaplastic astrocytoma (AA) requires multidisciplinary involvement. In this article, the literature on the treatment of patients with AA is reviewed, emphasizing randomized trials and key retrospective studies. The role of surgery, radiation therapy, and chemotherapy in newly diagnosed patients and those with recurrent disease is described. Basic science insights, advances in neuroimaging and neuropathology, and novel therapies targeting invasion, angiogenesis, and growth modulation will hopefully lead to improved outcome in this subset of patients with malignant glioma.