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Actin and dynein-like protein are involved in axoplasmic transport mechanism in saponized squid axons.

The particle transport in axons permeabilized with saponin was blocked by three actin-related proteins, 88 K protein/actin complex, actinogelin, and cofilin. The particle movement was reactivated by ATP, but neither by GTP nor by ITP. We conclude that an actin and a dynein-like protein are involved in retrograde phase of axoplasmic transport mechanism.