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The change of urinary steroid excretions in liver disease with special reference to an implication of hepatic dysfunction in pill users.

The profile steroid analysis of urine was attempted by gas liquid chromatography to investigate the influence of a hepatic lesion on steroid metabolism. This study includes patients with acute hepatitis (AH), chronic hepatitis (CH), and hepatic cirrhosis (HC); normal controls of both sexes; healthy women under oral contraceptive treatment; and premenopausal patients with breast cancer, cervical cancer, and amenorrhea. The presence of a hepatic lesion generally depressed the excretions of urinary steroids, but the spectrum of steroidal deviations (the combination of affected steroids and the direction and magnitude of deviation from the normal value) varied depending on the stage of the disease (AH, CH, and HC) and on the sex of the host. In male and nonpregnant female patients with AH, the excretion of androsterone exhibited the largest and most consistent reduction from the normal mean, but urinary etiocholanolone remained intact in the same patients.The excretion of pregnane compounds was not affected i...