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[Relationship between the expression of p53 and C-erbB-2 oncoproteins and biologic behaviors of human mucoepidermal carcinoma of salivary gland]

OBJECTIVE:To study the relationship between the expression of p53 and c-erbB-2 proteins and biologic behaviors of human mucoepidermal carcinoma.METHODS:The expressions of oncogene proteins p53 and c-erbB-2 in 32 cases of human mucoepidermal carcinomas were investigated with microwave immunohistochemistry.RESULTS:p53 and c-erbB-2 oncoproteins in duct epithelial cells around cancer tissues were 10.0% and 15.0%,respectively,but those in the acinar cells affiliated with the salivary gland ducts were negative. The positive rates of p53 oncoprotein and c-erbB-2 oncoprotein in mucoepidermal carcinoma were 40.6% and 46.9%,respectively. Both p53 and c-erbB-2 oncoproteins were expressed in mucous cells,epidermoid cells and intermediate cells of mucoepidermal carcinoma. The expression of p53 and c-erbB-2 oncoproteins in human mucoepidermal carcinoma tissues were related to histological patterns,differentiation degree of cancer and tumor recurrence (P<0.01).CONCLUSION:This study suggested that both p53 and c-erbB-2 on coproteins,as the markers for differentiation of cancer,might be useful in screening progress and evaluating prognosis of patients with mucoepidermal carcinoma.