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Modeling and simulation of the motion of nanoparticles in cylindrical capillaries allowing particle‐to‐wall interactions

The process of transporting nanoparticles at the blood vessels level stumbles upon various physical and physiological obstacles; therefore, a Mathematical modeling will provide a valuable means through which to understand better this complexity. In this paper, we consider the motion of nanoparticles in capillaries having cylindrical shapes (i.e., tubes of finite size). Under the assumption that these particles have spherical shapes, the motion of these particles reduces to the motion of their centers. Under these conditions, we derive the mathematical model, to describe the motion of these centers, from the equilibrium of the gravitational force, the hemodynamic force and the van der Waals interaction forces. We distinguish between the interaction between the particles and the interaction between each particle and the walls of the tube. Assuming that the minimum distance between the particles is large compared with the maximum radius R of the particles and hence neglecting the interactions between the particles, we derive simpler models for each particle taking into account the particles‐to‐wall interactions. At an error of order O(R) or O(R3)(depending if the particles are 'near' or 'very near' to the walls), we show that the horizontal component of each particle's displacement is solution of a nonlinear integral equation that we can solve via the fixed point theory. The vertical components of the displacement are computable in a straightforward manner as soon as the horizontal components are estimated. Finally, we support this theory with several numerical tests. Copyright © 2016 John Wiley & Sons, Ltd.