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[Effect of dimethoxy dichloro vinyl phosphate and fluorostigmine on the cyclic nucleotide content and dopamine level in the brain nigrostriatal system].

Study of the levels of cAMP, cGMP and dopamine in the caudate nucleus of rats 30 min and 24 h after acute poisoning with fluorostigmine or dimethoxy dichlorovinyl phosphate (DDVP) has shown that at the acute period the content of cGMP was elevated only in grave poisonings (by 46% after administration of fluorostigmine and by 64% after DDVP). Following 24 h the changes in the content of cAMP and cGMP were found to be retained only in the group of rats which received fluorostigmine (a 21% reduction and 27% rise, respectively). The dopamine level at the acute period was discovered to be altered only in mild patterns of poisoning (a 1.5-fold increase). After 24 h all the groups of animals demonstrated a 1.3-1.4 lowering of dopamine content.