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Editorial: DNA Vaccination: A Simple Concept with Challenges Regarding Implementation

Infectious diseases have plagued society from the beginning of civilization and have shaped civilization by altering the balance of power during crusades, as well as being used as biological weapons. However, development of methods to control infectious disease was not implemented until 1796 when Jenner recognized that individuals exposed to cow pox were apparently protected from the deadly scourge of small pox. This observation ushered in the era of vaccination. Approximately 100 years later, Pasteur further advanced the concept of vaccination by proposing that many of the diseases were caused by microorganisms. Based on this observation, he proposed that if one crippled or inactivated the microorganism and exposed an individual to this ‘‘vaccine,’’ the body would develop resistance against the specific disease. Indeed, Pasteur’s first success was dramatic when he saved the life of a boy bitten by a rabid dog. Since these humble beginnings,