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Studies on the immunostimulating and anti-tumour activity of a fraction isolated from Corynebacterium granulosum.

The immunostimulating activity of the anaerobic corynebacteriae is well documented. Fractions isolated from while cells have not been much investigated. We have reported that the immunostimulating activity is present in fractions isolated from Corynebacterium granulosum. A few fractions have shown anti-tumour activity in grafted tumours in mice. One of these fractions (P 40) has been investigated in more detail, since it proved to be inhibitory when administered after grafting of the non-syngenic P 815 tumour in mice.