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Nursing care of patients receiving orthoclone OKT 3.

Orthoclone OKT 3 (muromonab-CD3) is a monoclonal antibody to the T3 antigen of human T cells that has been used successfully to treat acute cell-mediated renal allograft rejection. The adverse reactions of OKT 3, though temporary, are quite disabling to patients. Common nursing diagnoses include potential alteration in respiratory function; altered body temperature: hyperthermia; alteration in comfort: pain; potential fluid volume deficit; potential for infection; and knowledge deficit. Patients receiving OKT 3 require diligent nursing care and monitoring during the course of therapy.