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FORMULATION AND ANTI-INFLAMMATORY EVALUATION OF POLY HERBAL GEL

The present investigation was aimed to formulate pathophysiology based herbal gel formulation for the most common chronic joint inflammatory disease rheumatoid arthritis. For treating arthritis, initially inflammation should be reduced. Topical application of drug at the site of application reduces swelling more effectively than internally administered drug. Four medicinal plants were selected which have been traditionally used as anti-inflammatory and antiarthritic drug and their extracts proven to be more potent than crude drugs. Oleo gum resins of Boswellia serrata, fruits of Capsicum annum, rhizomes of Curcuma longa and roots of Withania somnifera were selected and their extracts were prepared. These extracts were combined and gel formulation was made using carbopol 934P. For pharmacological evaluation of gel, carrageenan induced rat paw edema method was followed. After triple application of prepared gel, it showed 61.64% of activity and it was compared with allopathic standard gel and known ayurvedic product showed 67.04% and 54.48% respectively.