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A polymorphism of MS4A2 (−109T>C) encoding the β‐chain of the high‐affinity immunoglobulin E receptor (FcɛR1β) is associated with a susceptibility to aspirin‐intolerant asthma

Background and objective The MS4A2 gene, the β chain of the high‐affinity receptor for immunoglobulin (Ig)E, has previously been linked to atopy and asthma. The β‐chain of FcɛR1 enhances receptor maturation and signal transduction capacity, leading to the release of proinflammatory mediators and cytokines that can exacerbate the symptom of asthma. This study was performed to evaluate whether two genetic polymorphisms of the FcɛR1β gene (FcɛR1β−109T>C and FcɛR1β E237G) are associated with aspirin‐intolerant asthma (AIA).