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Effects of insulin‐like growth factor‐I administration on in vivo regulation of urea synthesis in normal subjects and patients with cirrhosis

Background: The anabolic effects of insulin‐like growth factor‐I (IGF‐I) may involve a decrease of hepatic nitrogen (N) clearance, but this has never been studied in humans. Patients with cirrhosis have low levels of IGF‐I and might benefit from IGF‐I therapy. Conversely, a possible decrease in hepatic N clearance by IGF‐I could increase the risk of hepatic encephalopathy.