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Acute stress induces down‐regulation of large‐conductance Ca2+‐activated potassium channels in the lateral amygdala

Key points •  Stress can lead to the development of behavioural disorders associated with cognitive impairments, depression and anxiety. •  Large‐conductance Ca2+‐activated potassium channels (BKCa) are highly expressed in the brain. Here we found that acute stress induced a significant reduction in BKCa channel expression in the amygdala of mice, which accompanied anxiety‐like behaviours. •  Activation of BKCa channels in the amygdala could reverse the stress‐induced anxiety‐like behaviours. This research may help us understand the underlying mechanisms of anxiety‐like behaviour induced by acute stress.