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Activation of translocator protein alleviates mechanical allodynia and bladder dysfunction in cyclophosphamide‐induced cystitis through repression of BDNF‐mediated neuroinflammation

Bladder pain syndrome/interstitial cystitis (BPS/IC) is a refractory disease accompanied by bladder‐related pain and hyperactivity. Studies have shown that the translocator protein (TSPO) modulates neuroinflammation and central sensitisation associated with pain. Moreover, we previously demonstrated that brain‐derived neurotrophic factor (BDNF) regulates neuroinflammation and mechanical allodynia in cyclophosphamide (CYP)‐induced cystitis through activation of glial cells. Here, we aimed to explore whether activation of TSPO attenuates mechanical allodynia and bladder dysfunction by regulating BDNF induced neuroinflammation in a CYP‐induced cystitis model.