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Is recommending breaks in sedentary behavior effective for improving health‐related outcomes?

While public health guidelines recommend engagement in moderate to vigorous physical activity (1), over the past decade there has been an increased focus on reducing sedentary behavior to improve health-related outcomes. The meta-analysis conducted by Chastin et al. (2) in this issue provides an initial synthesis of the evidence regarding the association between breaks in sedentary behavior, through standing or other forms of movement, and measures of adiposity and cardiometabolic health. Observational studies did not consistently support that breaks in sedentary behavior are significantly associated with a broad range of cardiometabolic health parameters. However, there was more consistency in observational studies when examining the association between breaks in sedentary behavior and adiposity, particularly body mass index. With regard to results from experimental studies, breaks in sedentary behavior influenced glycemic control, with potentially some influence on measures of inflammation. However, these effects were mostly apparent when breaks in sedentary behavior resulted in engagement in lightor moderateto vigorous-intensity physical activity.