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Do atypical antipsychotics reduce delirium symptoms in geriatric patients without dementia?

The answer is unclear. In older patients with lifelimiting illnesses who have delirium, risperidone increases delirium symptoms slightly compared to placebo (SOR: B, randomized controlled trial [RCT]). However, in older patients experiencing subsyndromal delirium after cardiac surgery, risperidone decreases the risk of progressing to full delirium by more than 50% (SOR: B, RCT). Copyright © 2019 by Family Physicians Inquiries Network, Inc. DOI 10.1097/EBP.0000000000000447