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Effects of malnutrition and quipazine on rat cerebral cortex ATPase activity during development.

Previous results suggested a possible association between brain serotonin (5-HT) and Na+-K+-ATPase, in vivo. We extended the study to the developmental response of this enzyme to early 5-HT changes induced by early malnutrition and by a serotonin agonist. Agonist treatment produced a response of the enzyme activity at early stages of development in normal and malnourished brains. The induction of 5-HT changes through malnutrition could be playing an important role in the development and maturation of Na+-K+-ATPase activity, and brain 5-HT receptors could possibly be involved in such a response.