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Regression, Recurrence and Cure in an Irradiated Mouse Tumour 1

Palliative radiotherapy aims at a fast rate of regression and a maximum delay in growth with radiation doses of subtolerance level; while radical radiotherapy aims at maximum local tumour control with radiation doses of tolerance level. These aims point to the importance of exploring the rate and the pattern of tumour regression, the delay in growth of recurrent tumours and the probability of local tumour control. Regression of both human and animal tumours following irradiation has always interested radiotherapists and radiobiologists for the following reasons: (I) Tumour regression is associated with symptomatic and psychological relief of the patient, and hence, rapid tumour regression is the goal of every radiotherapist. (2) A process of reoxygenation can be expected as the tumour shrinks rapidly following irradiation, with reduction of the number of hypoxic cells after the first dose, leading to a more effective second dose and fractionated irradiation (Howes 1969,Suit & Maeda 1967, Fowler et al. 1975, Kallman 1972, Fowler et al. 1974). (3) The rate and pattern of regression might be an early indicator of the outcome of the treatment and any further necessary therapy. In the present study, the gross response of a murine tumour, following single doses of irradiation, has been analysed during regression and recurrence in an attempt to find out its influence on the outcome of the treatment with single doses of X-ray alone and after minimizing the effect of hypoxic cells in the tumour with the hypoxic cell radiosensitizer misonidazole (Adams 1973, Fowler et al. 1976).