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Some effects of systemic N-hydroxyurea and N-hydroxyurethane on normal and n-hexadecane-treated rat skin in vivo.

Injections of the two cytotoxic agents, N-hydroxyurea and N-hydroxyurethane, have been shown to increase the normal skin arginase level but to diminish the increase in arginase level of n-hexadecane-treated skin. The effect of the cytotoxic agents on the n-hexadecane-induced hyperkeratotic response was negligible. These selective effects should be useful in experimental dermatology.