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Spatiotemporal expression of the VEGF‐receptor 2 during lung development

The VEGF/VEGFR‐2‐system is a key regulator of blood vessel formation. The expression of the receptor mainly is regulated by HIF‐2α and predominantly restricted to the vascular endothelium. Recent findings suggested a role of VEGF for the pulmonary epithelial cell function. We investigated the expression of VEGFR‐2 at different stages of mouse lung development; in isolated murine alveolar type 2 cells we determined VEGFR‐2 expression and signaling using Western Blots for MAPK.