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Hyperthermic intraperitoneal chemoperfusion in the treatment of locally advanced intra‐abdominal cancer

Surgical treatment of intra‐abdominal cancer is often followed by local recurrence. In a subgroup of patients, local recurrence is the sole site of disease, reflecting biologically low‐grade malignancy. These patients might, therefore, benefit from local treatment. Recently, debulking surgery followed by hyperthermic chemoperfusion has been proposed in the treatment of locally advanced or recurrent intra‐abdominal cancer. This paper reviews the rationale and assesses the currently accepted indications for and results of this novel treatment.