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Type I Neurofibromatosis Associated with Hypereosinophilic Syndrome: A Rare Case Report

Hypereosinophilic syndrome (HES) encompasses a group of disorders characterized by marked peripheral blood eosinophilia, tissue eosinophilia, or both, resulting in organ damage attributable to the eosinophilia. Type I neurofibromatosis (NF-I) is an autosomal dominant genodermatosis with an increased risk of developing malignancies. HES was also considered as paraneoplastic presentation and it is proved to arise in combination with hematological malignancies such as chronic myeloid leukemia (CML), acute lymphocytic leukemia (ALL), and non-Hodgkin lymphoma (NHL). Here, we have reported a rare case of HES associated with NF-I that has not been reported so far, which may improve the knowledge of association between NF-1 and hematological malignancies.