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Gene conversion disparity in yeast: its extent, multiple origins, and effects on allele frequencies

The extent of disparity in gene conversion direction in yeast (Saccharomyces cerevisiae) is important for recombination mechanisms and for effects of conversion on allele frequencies in populations. An analysis of published and unpublished data demonstrates that yeast frequently shows significant and extensive conversion disparity, contrary to many published statements. All types of mutation – base-substitutions, frameshifts and longer deletions and additions – can show significant 6:2/2:6 and/or 5:3/3:5 disparity. There was little correlation between the occurrence of 6:2/2:6 and 5:3/3:5 disparities; when both were significant, they were more often in opposite directions than in the same direction. Surprisingly, there was little correlation between a mutation's molecular nature and its disparity properties, which generally seem unpredictable. Disparity in yeast has multiple origins. From the equations discussed, all disparity types can be explained by one or more of: correction direction disparity, chromatid invasion disparity (including cases caused by different frequencies of double-strand breaks or gaps in nonsister homologous chromatids), strand invasion disparity, and different correction frequencies for the two types of mispair for a heterozygous mutation. Levels of overall disparity and of conversion frequency mean that conversion must often change allele frequencies in sexually reproducing yeast populations.