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Effect of acute and chronic exposure to heat on pharmacokinetic parameters of digoxin in rats.

Digoxin pharmacokinetic parameters in acute heat-exposed male rats (AHE) maintained for 3 hours at 35 degrees C, and chronic heat-exposed rats (CHE) maintained at 35 degrees C for 4 weeks, were compared to control rats (C) maintained at 22 degrees C. Digoxin concentration in the plasma was measured by radioimmunoassay which gave values similar to thin layer chromatography method. The half life time of digoxin during the elimination phase of the drug (t 1/2 beta) was similar in all three experimental groups (2.8; 2.7; 3.0 hrs) while the values obtained by extrapolation of digoxin plasma concentration to zero time (CpO) was 40% higher in AHE rats and 375% higher in CHE rats than in C rats. The apparent distribution volume of the drug (Vapr) was 40% lower in AHE rats and 80% lower in CHE rats as compared to C rats.