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Effect of Low‐dose Irradiation on Pregnant Mouse Haemopoiesis

Summary. The effects of low‐dose gamma radiation to haemopoietic progenitor cell compartments of the marrow and spleen of virgin female mice and pregnant mice were studied. Microplasma clot cultures were used to assess burst‐forming uniterythroid (BFU‐E) and colony‐forming unit‐erythroid (CFU‐E) activity, and double‐layer agar cultures were established to evaluate granulocyte‐macrophage colony‐forming cell (GM‐CFC) and macrophage colony‐forming cell (M‐CFC). The apparent shift in maternal erythropoiesis from the bone marrow to the enlarged spleen was reflected by an increase in the numbers of CFU‐E and BFU‐E per spleen and a concomitant decrease in CFU‐E and BFU‐E per femur. Whereas maternal GM‐CFC values per femur increased 36%, maternal GM‐CFC per spleen increased by 172% compared to virgin values. There was a greater decrease in M‐CFC per spleen than per femur in the pregnant animal when values were compared to the virgin animal. Total‐body irradiation to the day‐10·5 pregnant mouse caused a further suppression of day‐14·5 medullary erythropoiesis (i.e. decreased CFU‐E values) compared to the response of the virgin female mouse. An ability of the maternal spleen to support further compensatory erythropoiesis following increasing doses of radiation was demonstrated. 4 d after 1·0 Gy exposure, maternal values for GM‐CFC per femur or spleen decreased to nonirradiated virgin mice values. M‐CFC per maternal femur decreased following 1·5 Gy, but M‐CFC per spleen appeared to be unaffected with doses from 0·5 to 2·0 Gy.