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[EB virus infection and expression of P53 and P16 in non-Hodgkin's lymphoma].

OBJECTIVE
To observe the presence of Epstin-Barr virus (EBV) and expression of P53 and P16 in the non-Hodgkin's lymphoma (NHL) occurring in the nasal cavity and pharyngeal Waldeyer's ring.


METHODS
In situ hybridization was used to detect EBV-DNA and P16-mRNA and immunohistochemical staining was used to examine the expression of LMP1, P53 and P16 in the 36 cases. Five cases whose EBV-DNA were negative at first assay by hybridization was re-detected for EBV-DNA by PCR.


RESULTS
Positive expression rates of EBV-DNA, LMP1, P16 mRNA, P53 and P16 were 63.9%, 27.8%, 30.6%, 19.4% and 22.2%. P53 and P16 expressions were not significantly different between T cell NHL and B cell NHL, nor were them significantly different between EBV positive and negative cases.


CONCLUSION
A higher percentage of EBV infection was detected in the nasal cavity and pharyngeal Waldeyer's ring in NHL. EBV infection was not significantly associated with P53 and P16 expresions in NHL.