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Efficacy, safety and tolerability of the fixed combination of ibuprofen (400 mg) and caffeine (100 mg) compared with ibuprofen, caffeine and placebo in in acute pain

Does combining ibuprofen with caffeine have advantages over ibuprofen alone in the treatment of acute pain? A randomised, placebo-controlled, double-blind study compared efficacy, safety and tolerability of an ibuprofen + caffeine combination with that of the separate substances or placebo in acute, moderate to severe pain. The combination was superior to all the other treatments in relation to pain relief over 8 hours, onset of action, responder rate and the ingestion of a rescue (escape) analgesic; safety and tolerability were demonstrated. Thus the combination of ibuprofen and caffeine is a superior treatment option compared with ibuprofen alone for the treatment of acute pain.