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Irradiation of platelet components: inhibition of lymphocyte proliferation assessed by limiting‐dilution analysis

BACKGROUND: Using a limiting‐dilution analysis (LDA) assay that measures clonigenic T cells, it has been demonstrated that, with 2500 cGy, there is no T‐cell growth in red cell components irradiated in blood bags. In the current study, the LDA assay was used to investigate the effect of gamma radiation on the proliferative capacity of T cells in plateletpheresis components.