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Programmed, intermittent boluses versus continuous infusion to the sciatic nerve – a non‐inferiority randomized, controlled trial

Trials comparing programmed, intermittent boluses (PIB) and continuous infusion in catheter‐based nerve blocks found no analgesic differences. However, as these trials used equal doses of local anesthetic (LA), the time of action of each bolus was not accounted for. Therefore, the dose‐sparing benefits of PIB may have been overlooked. We compared the analgesic effect of boluses administered in intervals resembling the time of action of each bolus with continuous infusion. We hypothesized that PIB provided non‐inferior analgesia despite consuming less LA.