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ISBT Scientific Series – State of the Art Invited speakerProtein blood group systems: Berlin and beyond

As of July 2010, 24 of the 30 blood group systems recognized by the International Society of Blood Transfusion (ISBT) are protein‐based. These proteins are oriented within the red cell membrane as single pass membrane proteins, multi‐pass proteins, glycosylphosphatidylinositol‐linked proteins, or adsorbed from the plasma. At the 2010 meeting of the ISBT working party on the red cell immunogenetics and blood group terminology, 14 ‘new’ high‐incidence blood group antigens were ratified into 10 of the systems, one antigen was made obsolete, and a new collection was established. Early in 2012, two new protein‐based blood group systems were established. Both are members of the ATP‐binding cassette family of proteins.