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A shape-navigated image deformation model for 4D lung respiratory motion estimation

Intensity modulated radiation therapy (IMRT) for cancers in the lung remains challenging due to the complicated respiratory dynamics. We propose a shape-navigated dense image deformation model to estimate the patient-specific breathing motion using 4D respiratory correlated CT (RCCT) images. The idea is to use the shape change of the lungs, the major motion feature in the thorax image, as a surrogate to predict the corresponding dense image deformation from training.