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Antibody‐induced changes in expression of an immunoglobulin surface antigen

An IgG1‐secreting myeloma possesses Ig‐related surface antigen, Ig‐mem, detected both by a cytotoxic and a 125I‐labeled anti‐Ig binding assay. The properties of Ig‐mem were studied by examining the fate of 125I‐labeled rabbit anti‐Ig and the complement sensitivity of cells sensitized by the binding of labeled antibody at 0 °C. Shifting the temperature to 24 °C or 37 °C leads to a rapid loss of sensitivity to lysis by complement, as well as a loss in the capacity to detect the rabbit antibody on the cell surface. These reactions occur without any appreciable loss of radioactivity from cells at 24 °C. The 125I‐labeled antibody is subsequently degraded to amino acids (detected as iodotyrosine) more rapidly at 37 °C than at 24 °C.