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The contractile action of slow reacting substance of anaphylaxis (SRS-A) on guinea-pig isolated lung strip [proceedings].

Slow reacting substance of anaphylaxis (SRS-A) causes bronchoconstriction in the guinea-pig (Berry & Collier, 1964). Drazen & Austen (1974) showed that this response comprised a reduction in pulmonary compliance without any change in pulmonary resistance. This suggests a selective constriction of small peripheral, rather than large central, airways. Lulich, Mitchell & Sparrow (1976) have suggested that responses of isolated strips of lung parenchyma to drugs reflect effects on peripheral airways. We have therefore examined the effects of SRS-A on guinea-pig isolated lung strip and compared them with those on guinea-pig isolated ileum, a tissue which is very sen- sitive to SRS-A