{'fraction_non_alphanumeric': 0.025878003696857672, 'fraction_numerical': 0.009242144177449169, 'mean_word_length': 5.376470588235295, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Effect of suppressor of cytokine signaling on hepcidin production in hepatitis C virus replicon cells

Aim:  Hepcidin is a key regulator of systemic iron metabolism and its expression is modulated by hepatitis C virus (HCV) infection. Suppressor of cytokine signaling 1 (SOCS‐1) and SOCS‐3 act as negative regulators of the Jak/signal transducers and activators of transcription signaling pathway. In this study, we investigated how HCV infection modulates SOCS‐1 and SOCS‐3 production and how these SOCS proteins affect hepcidin production.