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The Interaction between Ventricle to Brain Ratio and Serum Klotho on Cognition in Older Adults at Risk for Alzheimer’s Disease

Ventricle to brain volume ratio (VBR) may be associated with Alzheimer’s disease (AD) progression and is a robust correlate of cognition in AD. Klotho is a circulating protein positively associated with cognition. The purpose of this study was to evaluate whether serum klotho attenuates the adverse effect of higher VBR on cognition in older adults at risk for AD.