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Role of Leukotrienes in Gastric Mucosal Injury Induced by Ischemia–Reperfusion in Rats

This study was designed to clarify the role of leukotrienes (LTs) in gastric injury induced by ischemia–reperfusion in rats. Gastric lesions were produced by clamping of the celiac artery and by reoxygenation following clamping. Administration of AA-861, a lipoxygenase inhibitor, significantly inhibited the increase in the total area of the gastric erosions and the increase in thiobarbituric acid–reactive substances in the gastric mucosa. Administration of YM-638, a peptide LT antagonist, showed protective effects similar to AA-861. These results suggest that the protective effects of AA-861 and YM-638 against ischemia–reperfusion–induced gastric injury were due to their antioxidative action.