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Effects of GST null genotypes on individual susceptibility to atherosclerotic cardiovascular diseases: a meta-analysis

Abstract Some genetic association studies tried to investigate potential associations between glutathione S-transferase (GST) null genotypes and atherosclerotic cardiovascular diseases (ASCVD). However, the results of these studies were not consistent. Thus, we performed the present meta-analysis to explore associations between GST null genotypes and ASCVD in a larger pooled population. Systematic literature research was performed in PubMed, Web of Science, and Embase to identify eligible studies. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the strength of associations. Totally 47 studies were included for analyses. Pooled analyses suggested that GSTM1 (p = .007, OR = 1.29, 95%CI 1.07–1.56) and GSTP1 (p = .01, OR = 1.28, 95%CI 1.06–1.55) null genotypes were significantly associated with individual susceptibility to ASCVD in overall population. Further subgroup analyses revealed similar positive results for GSTM1 null genotype in South Asians and patients with coronary artery disease (CAD). No other significant results were observed for GST null genotypes in overall and subgroup analyses. In conclusion, our meta-analysis suggested that GSTM1 and GSTP1 null genotypes could impact individual susceptibility to ASCVD. These results suggested that these variations could be used to identify individuals at higher susceptibility to ASCVD.