{'fraction_non_alphanumeric': 0.03725490196078431, 'fraction_numerical': 0.021568627450980392, 'mean_word_length': 4.1033333333333335, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 1, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Assessment of the cytokine profile in patients with allergic rhinitis caused by sensitization to house dust mite

The aim of the study was to evaluate the serum cytokine profile of patients with allergic rhinitis (AR) sensitized to house dust mites and to establish their role in the regulation of IgE synthesis 
Materials and Methods. The study included 60 patients with AR at the age of 20-60. According to the level of total IgE (IgE>100 kU/L), patients were divided into two groups with an IgE-dependent and IgE-independent form of AR. In the study, the serum levels of IL-2, g-IFN, IL-4, IL-5, IL-13, IL-10 and TGF-b in the blood serum were determined by ELISA. 
Results. According to the study, it was found that patients with an IgE-dependent form of AR are characterized by a decrease in the level of Th1 cytokines IL-2 and g-IFN, an increase in the level of Th2 cytokines – IL-4, IL-5 and IL-13 and a decrease in Treg cytokines – IL-10 and TGF- b. At the same time, a significant decrease in the level of inhibiting cytokine IL-10 was established in comparison with the group of patients with an IgE-independent form of AR. For patients with an IgE-independent form, only elevated levels of IL-13 were found. No significant differences were found between other Th1 and Th2 and Treg cytokines. 
Conclusions. The study showed that in patients with AR sensitization to house dust mites, IL-13 acts as a key cytokine in the IgE-independent form of AR, which can be important in the future for both predicting and treating AR.