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An In vitro study to compare the antibacterial activity of Kaphaketu Rasa and its combination with Rasa Sindura in selective respiratory pathogens

Introduction: Respiratory tract infection refers to any infectious disease involving the respiratory tract. The adverse effect of antibiotics and antibiotic resistance are the difficulties faced by the medical profession. It is the need of the hour to identify the antibacterial potential of the herbo – mineral drugs. So, this study is an effort to compare the efficacy of Kaphaketu rasa alone and its combination with Rasasindura against the bacteria causing respiratory infections such as Staphylococcus aureus and Streptococcus pneumoniae. Methods: Rasasindura and Kaphakethurasa were prepared according to the classical reference. For Rasasindura preparation Kupipakva method was done. Kaphaketu rasa was prepared after doing bhavana of sodhita Vatsanabha, Tankana, Pippali and Sankha Bhasma with Ardraka swarasa. Antibacterial activity of Kaphaketu rasa, Rasasindura and its combination were tested by the agar well diffusion method. Results: Aqueous extract of Kaphaketu rasa and combination of Kaphaketu rasa with Rasasindura have zone of inhibition against both S. pneumoniae and S. aureus, which shows the antibacterial activity of the drugs. Aqueous extract of Rasasindura alone did not show any zone of inhibition against both bacteria. Conclusion: Kaphaketu rasa has significant antibacterial activity against the respiratory pathogens S. aureus and S. pneumoniae. The findings suggest that Kaphaketu rasa can be used in respiratory tract infection and Rasasindura can be added with it for an additive effect.