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Quantitative analysis of lung perfusion in patients with idiopathic pulmonary arterial hypertension

Objective To assess the value of lung perfusion scan for the quantitative analysis of id-iopathic pulmonary arterial hypertension (IPAH). Methods Both lung perfusion scan and right heart cath-eterization were performed in 30 patients diagnosed as IPAH. Perfusion indexes (P index) were obtained from lung perfusion images using software " NIH Image". Lung perfusion scan was also performed in 12 age-matched control subjects with perfused area rate (PAR) curve plots. A Pearson correlation coefficient was determined between the P index and hemodynamic parameters. The patients were divided into 3 groups based on patterns of lung perfusion scintigraphy: group A with normal perfusion, group B with apical prone perfusion, and group C with mottled perfusion. The differences of P index among the groups were assessed by student's t-test. Results The P index was closely correlated with mean pulmonary arterial pressure (mPAP) and total pulmonary resistance (TPR; r=0.541 for mPAP, P 0.05). Conclusions The quantitative analysis of P index from lung perfusion scan is an accurate indicator of hemodynamic parameters. Quantitative assessment of lung perfusion may provide useful information for se-verity assessment of IPAH. 
 
Key words: 
Hypertension, pulmonary;  Radionulide imaging;  MAA