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Heat-labile serum alkaline phosphatase as an index of growth in healthy Nigerian infants and children.

The contribution of osteoblasts to the total serum alkaline phosphatase in Nigerian infants and children has been determined. 300 male & female subjects from birth to age 15 showed that the ratio of the heat-labile serum alkaline phosphatase ranged between 0.46 and 0.77 in healthy subjects while that of 6 children who looked smaller than the mean for their ages ranged from 0.21-0.37. The serum heat-labile alkaline phosphatase value decreases with height; this is most marked between the heights of about 50 centimeters to 100 centimeters; corresponding with the first 6 years of life. This study supports the view that growth as measured by age height and weight is closely related to heat-labile alkaline phosphatase. This enzyme therefore provides a useful index for the measurement and assessment of growth in Nigerian infants and children.