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The Role of Complement in the Treatment of Tumor Diseases

The phenomenon of antibody is dependent on the cell in which occurs the main mechanism of action of all targeted antitumor preparations containing monoclonal or polyclonal antibodies. Successful manifestation of this phenomenon is possible only with the correct ratio between the antigens of cancer cells, antibodies specific to them and the required amount of complement. The following paper shows the need to monitor the quantitative content of complement in the patient's serum and correct its content by introducing the required volume of fresh frozen plasma as a source of exogenous complement. The required amount of specific antibodies (dosage of the drug) must be determined after proper correction of the amount of complement in the patient's blood. If this condition is met, the maximum efficacy of the drug and the increased success of the treatment of tumor diseases will be achieved.