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A modified V-Y chondromucosal composite flap for correction of secondary cleft nasal deformity: photogrammetric analysis of a case-control study.

In our opinion, it is necessary to demonstrate that the cells produced by this method meet the in vitro criteria of the mesenchymal stromal cells. Moreover, it would be interesting to compare the adipose-derived stromal cell yield obtained with these mechanical methods to the cells obtained with specific devices. It is important, because if the cell yield is equivalent, this will reduce the cost of the stromal vascular fraction– grafted cells, which could be extremely interesting in regenerative medicine. In conclusion, the authors have limited their investigations to phenotypic characterization without realizing differentiation in the mesodermal lineage and colony-forming unit-fibroblast experiment. It seems insufficient to demonstrate that the cells obtained are adipose-derived stromal cells. DOI: 10.1097/PRS.0000000000000927