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Drug absorption kinetics in goldfish.

A model is presented for relating turnover time in goldfish to the concentration of drug in the bathing solution. The model, based on passive transport and the existence of a critical concentration of drug within the fish being required for turnover, was applied to the dose–response data of eight homologous esters of p-aminobenzoic acid. Absorption rate constants, relative membrane water partition coefficients, and critical concentrations were evaluated for the methyl through hexyl esters. Heptyl aminobenzoate was only effective in saturated solution. No turnover could be produced by the octyl ester which has a solubility below the critical concentration required for activity.