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Butyrate and the cytokine‐induced α1‐proteinase inhibitor release in intestinal epithelial cells

Background α1‐proteinase inhibitor (α1‐PI), an anti‐inflammatory protein thought to play a role in the intestinal inflammation, is synthesised by and released from the intestinal epithelial cells. IL‐1β is a key proinflammatory cytokine in the abnormal immune response that occurs in inflammatory bowel disease. Butyrate is a normal luminal constituent in the colon, known to be of benefit in preventing inflammatory bowel disease. Direct modes of action of butyrate in intestinal inflammation have been poorly studied so far. The aim of this study was to investigate the effects of butyrate on cytokine‐mediated α1‐PI release in intestinal epithelial cells.