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The usefulness of serum tryptase in the diagnosis of shrimp anaphylaxis in children

Results: In both groups of patients, median tryptase levels were significantly elevated after the onset of shrimp challenge as compared to baselines (baseline tryptase 1.08, peak tryptase 2.33 2g/L in anaphylaxis group; baseline tryptase -1.49, peak tryptase 1.56 2g/L in non-anaphylaxis group, p G 0.05). The delta tryptase (peak minus baseline) values in the anaphylaxis group was significantly higher than non-anaphylaxis group (1.33 VS 0.125 2g/L, p = 0.0004). The tryptase ratio (peak divided by baseline) values in the anaphylaxis group was also significantly higher than nonanaphylaxis group (2.11 VS 1.055, p = 0.0001). Using the recommended cut-off range (peak tryptase G 12.0 2g/L) the sensitivity of such cut-off was 0.11 with specificity of 1.0.