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Injectable Collagenase for the Treatment of Dupuytren Contracture: A Critical Analysis Review

Dupuytren disease is a benign fibroproliferative disorder of collagen that affects the palmar fascia of the hands, resulting in nodules and cords. These pathological cords contain myofibroblastic cells that contract, producing progressively disabling fixed flexion deformities1. The metacarpophalangeal and proximal interphalangeal joints, and the ring and small fingers, are most often affected. Despite the recent surge in scientific research regarding this common disease, the exact pathogenesis and etiology remain unclear. However, there is general agreement that this is a genetic disorder with variable penetrance2-4 as there is an increased incidence among the relatives of patients with Dupuytren disease. In addition, other studies have demonstrated that Dupuytren disease is associated with diabetes5, …