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Occurrence of HLA‐DR Reactive Microglia in Alzheimer's Disease

Sensitive immunohistochemical procedures were used to detect reactive microglia (macrophages) positive for HLA-DR in postmortem tissue in cases of Alzheimer’s disease.’ In gray matter, these macrophages were concentrated in areas of senile plaque formation (FIG. 1A). They were also found in white matter, such as the anterior commissure, which presumably carries axons of degenerating cortical neurons (FIG. 1 B). Double immunostaining with antibodies to HLA-DR and glial fibrillary acidic