{'fraction_non_alphanumeric': 0.02195945945945946, 'fraction_numerical': 0.002533783783783784, 'mean_word_length': 5.8497109826589595, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Evaluation of the Correlation between Porphyrin Accumulation in Cancer Cells and Functional Porphyrin Positions of the Phenyl Group

Porphyrin selectively shows tumour accumulation and has attracted attention as a carrier molecule for drug delivery systems (DDS). Porphyrin has two functional sites termed the meso‐ and β‐positions. In previous work, meso‐porphyrin derivatives with an alkyl group were found to exhibit greater accumulation in human breast cancer cells (MCF‐7). To identify the correlation between porphyrin accumulation and functional porphyrin positions of other functional groups, the accumulation of porphyrin derivatives with a phenyl group was investigated. The β‐porphyrin derivative with a phenyl group showed higher accumulation in MCF‐7 cells and greater affinity for albumin than the meso‐porphyrin derivative. The results of density functional theory (DFT) calculations suggest that the β‐porphyrin derivative with a phenyl group had higher planarity across the total structure than the meso‐porphyrin derivative. It was concluded that the greater planarity of the β‐porphyrin derivative with a phenyl group might lead to superior MCF‐7 cell accumulation.