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and fetal tissue. The overview of clinical cytogenetics provides a very good summary of the indications for preand postnatal cytogenetic studies and the means by which these can be achieved in a clinical setting. In addition, a brief guide to the major chromosome abnormalities is given. The background information on CVS and the relative advantages and pitfalls of direct and culture methods is well presented. The chapters on amniotic fluid and fetal tissue analysis provide an excellent and informative review of these subjects, with a wide range of techniques that should suit all tastes. Choice of in situ or flask harvesting methods is given and the different requirements for analysis and the detection of mosaicism from these two different types ofharvest is discussed in detail. In all cases the sections devoted to background information, troubleshooting, and time consideration provide a helpful adjunct to the methods. Current Protocols in Human Genetics can be wholeheartedly recommended to all workers in the human genetics field with a basic grounding in molecular biology, but you will have to buy Current Protocols in Molecular Biology if you are not to be left searching for basic protocols essential for your research.