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Analysis of downstream events of human Pax‐5B signalling in B lymphocytes

The Pax‐5 gene, which codes for a potent transcription factor named BSAP, plays an important role in B lymphocyte development and oncogenesis. Aberrant expression of Pax‐5 has been associated with different cancer such as lymphomas, leukemia and testicular cancer. Under the control of two alternative promoters, Pax‐5 can simultaneously express two different forms (i.e. Pax‐5A and Pax‐5B). Through the use of a ribozyme‐based gene suppression system, we demonstrate that Pax‐5B is an important factor in the regulation of intracellular signalling cascades and elements leading to modulation of biological processes such as cellular proliferation, survival and apoptosis. More specifically, this study characterizes the implication of the hPD‐1 receptor, Bax/Bcl2 ratios and p53 in Pax‐5B‐mediated apoptosis. These findings bring new insight into autoimmune diseases and cancer processes in human B lymphocytes. Research support from New Brunswick Innovation Foundation and Canadian Institutes in Health Research and Atlantic Innovation Foundation.