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SUPPRESSION OF ATHEROSCLEROSIS IN CHOLESTEROLEMIC RABBITS BY DIMETHYL SULFOXIDE

Abstract : The results of this study indicate that DMSO retards the development of dietary cholesterol-induced atherosclerosis in rabbits and suppresses the accumulation of cholesterol in tissues despite severe hypercholesterolemia. While the mechanism of action of DMSO in suppressing atheosclerosis is not known, our in vitro studies suggest that one of its antiatherogenic effects is related to its capacity to reduce the binding, uptake, and degradation of plasma LDL by tissues and cells.