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Renal arachidonic acid metabolism.

Renal prostaglandin synthesis has been the focus of extensive investigation during the past decade. This chapter reviews the cellular localization of renal arachidonic acid metabolism in view of the substantial recent progress in the isolation and culture of renal cell types. The study of such specific renal cell types permits a more exact correlation of arachidonic acid metabolism, hor­ monal recognition, and specific kidney functions. In addition, we have chosen to describe a pathophysiological model that exhibits exaggerated prostaglandin (PG) synthesis and demonstrates the impact of nonrenal cells on kidney arachidonate metabolism and function.