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Evidence that platelet buoyant density, but not size, correlates with platelet age in man

Following infusion of 51Cr‐labeled autologous platelets into normal subjects, high‐density (HD) and low‐density (LD) platelet cohorts were isolated by prolonged centrifugation in isosmotic arabino‐galactan (Stractan). Specific radioactivity of LD platelets declined rapidly post‐infusion (T1/2 = 1.5 days), but specific radioactivity of HD platelets remained constant or increased over a 3–4‐day period and gradually declined for 6–7 days thereafter. These differences were exaggerated when platelet cohorts enriched in LD or HD cells by slow centrifugation in high‐density albumin were labeled and transfused. Mean survival of a platelet cohort enriched with HD cells was significantly (P < 0.02) shorter (7.73 days) than that of a cohort enriched with LD cells (9.33 days). In normal subjects treated with aspirin, capacity for thromboxane synthesis was regained more rapidly (P < 0.05) in LD than in HD platelets. HD and LD platelets differed only slightly in mean volume (HD platelets = 7.57 μ3, LD platelets = 6.87 μ3, 0.05 < P < 0.01).