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Repair of Acute Post Infarction Mitral Regurgitation with Papillary Muscle Reimplantation - A case report -

A 53-year-old man presenting with dyspnea and chest pain was diagnosed with acute myocardial infarction secondary to occlusion of the left circumflex coronary artery. Urgent revascularization by percutaneous stenting was successfully performed. However, the post-echocardiography revealed a ruptured papillary muscle that was causing severe mitral regurgitation and aggravation of congestive heart failure. The patient subsequently underwent mitral valve repair with papillary muscle re-implantation. Postoperative echocardiography showed a competent mitral valve without residual stenosis or regurgitation. The patient was discharged from the hospital with an uneventful recovery and has been doing well on outpatient follow up.


CASE REPORT
At surgery, the heart was exposed through a standard median sternotomy. Moderate hypothermic cardiopulmonary bypass at 27 o C esophageal temperature was performed through selective cannulation of the aorta, superior vena cava, and inferior vena cava. Cardioplegic induction was achieved by antegrade root infusion of cold blood cardioplegic solution.
Maintenance of cardioplegia was achieved by continuous retrograde coronary sinus infusion of cold blood cardioplegia.
The mitral valve was exposed by transseptal incision ex-

DISCUSSION
Severe MR occurs in about 3% of patients presenting with an acute myocardial infarction, and is associated with an in-hospital mortality of up to 70%. Although progress in surgical management has led to improved outcomes over the decades, operative mortality remains high [1].
The papillary muscle is a contiguous structure of the adjacent left ventricular wall that serves to preserve the contractile function and acts as an anchor for the chordae tendinae. There are usually one anterolateral and two or three posteromedial papillary muscles [2]. While the anterolateral papillary muscle receives dual blood supply from the left anterior descending and circumflex coronary arteries, the posteromedial papillary muscle usually receives a single blood supply from either the right or left circumflex coronary artery.
As a result, the posteromedial papillary muscle is relatively more vulnerable to rupture than the anterolateral papillary muscle, with a nearly three-to six-fold higher reported rate of disruption after acute myocardial infarction [3].
Repair is usually recommended over replacement for the treatment of functional ischemic MR, as it is generally conducive to superior survival outcomes [4]. However, in acute postinfarction papillary muscle rupture, experience is limited and most surgeons prefer to replace rather than repair the mitral valve. This is mainly due to their uncertainty regarding

Repair of Acute Post Infarction Mitral Regurgitation with Papillary Muscle Reimplantation
− 287 − the durability of a repair that inevitably requires suturing onto friable and infarcted myocardial tissue. In addition, the potential for a longer aortic cross clamping time, greater technical difficulties in achieving a successful repair, and the likelihood of ventricular remodeling progression with consequent recurrence of mitral regurgitation have also led to a greater preference for valve replacement in this subset of patients [5,6].
In the present case, one of two papillary projections of the posteromedial papillary muscle was disrupted. The basal portion of the main posteromedial papillary muscle appeared to be non-necrotic. Therefore, from the perspective of the papillary muscle mass involvement, the posteromedial papillary muscle was partially infarcted and thus considered to be amenable to repair by re-attaching the detached papillary muscle head to normal tissue. Fasol et al. [7] reported a modified papillary muscle re-implantation technique involving reattaching the ruptured papillary muscle tip to a healthy area of the papillary muscle and reinforcing the repair with additional sandwiched pericardial pledgetted PTFE sutures. We avoided approximating necrotic tissue directly with necrotic tissue by placing the sutures through healthier-appearing tissue that was closer to the ventricular endocardium at the papillary muscle base.
A search of the literature published in Korea revealed surgery for acute post infarction papillary muscle rupture performed in nine patients [3,8,9]. Of note, in all of them, the mitral valve was replaced instead of being repaired. Therefore, to the best of our knowledge, this is the first reported case of a post infarction papillary muscle rupture that was treated with reimplantation of the papillary muscle in Korea. Although the repair was successfully performed, further studies are warranted to substantiate and validate the durability of this method.