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A COMPARISON OF THE EFFECTS OF ACCUMULATED DOSES OF PENTAZOCINE AND PETHIDINE ON VENTILATION AT PACO2= 45 mm Hg

Five young healthy subjects whose alveolar CO2 tensions were maintained constant at 45 mm Hg by adjustment of CO2 admixture to the inhaled air were given pentazocine or pethidine in three doses of 15 mg/70 kg b.w. and 50 mg/70 kg b.w., respectively, at 20‐minute intervals. Ventilatory depression developed at a significantly greater rate after pethidine than after pentazocine, in four out of the five subjects.