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Fluorination of β-Ketoesters and β-Ketoamides Based on PhI(OAc)2

Herein, a nucleophilic fluorination reaction to construct fluorine-containing β -ketoesters and β -ketoamides is reported. The reaction uses PhI(OAc) 2 as oxidant and 3HF•Et 3 N as fluorinating reagent. It can effectively build a series of fluorochemical compounds containing quaternary carbon center under room temperature reaction conditions for 30 min. Compared with the traditional electrophilic fluorination reaction, this method has the advantages of no metal participation, short reaction time, simple reaction conditions and high reaction yield.