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Urinary excretion of 51 Cr from labeled erythrocytes. An index of erythrocyte survival.

The urinary excretion of radioactive chromium ( 51 Cr) can be used as an index of erythrocyte survival, using washed erythrocytes labeled with 51 Cr, in a study period of four days. This method also appears to be a better index of erythrocyte destruction than the conventional erythrocyte survival measurement because the 51 Cr activity in the urine is a function only of the rate of in vivo destruction and elution of labeled erythrocytes, and data obtained from excretion of 51 Cr show virtually no dispersion from a simple exponential curve. The dose can be decreased to 10 microcuries or less and the amount of labeled blood injected can be as little as 1 ml. This method has a potential for use in in vivo compatibility testing of donor blood.