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[Control of bone remodeling by nervous system. Regulation of glucose metabolism by skeleton. - Tangent point with nervous system -].

It has been demonstrated that osteocalcin, osteoblast-secreted molecule, regulates energy metabolism through acting on pancreatic β-cells and adipocytes, while it has been established that the adipocyte-derived hormone leptin regulates bone metabolism through central nervous system and sympathetic nervous system. Recently, it has been reported that sympathetic tone into osteoblasts is a mediator of leptin regulation of insulin secretion. These functional relationship between bone and multiple organs illustrates the pivotal role of the skeleton in the regulation of our major physiological functions including energy metabolism.