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Familial basal cell carcinomas

of familial carcinomas’. By reading the current literature, this question can clearly be answered in the negative. The trait certainly exists but cannot really be regarded as new because it was comprehensively described already in the year 2000. Coquart et al. mention the various syndromes associated with BCC and argue: ‘The delineation of these familial cancer syndromes, in particular Gorlin syndrome, has so far overshadowed the possibility that a hereditary non-syndromic type of tumour may also exist.’ In Happle’s article, we find this statement in a wondrously similar form: ‘The delineation of these multiplefaceted birth defects, in particular Gorlin syndrome, has overshadowed so far the possibility that a hereditary nonsyndromic type of such tumors may also exist.’ Happle presented two lines of evidence in favor of the delineation of a Mendelian trait characterized by non-syndromic multiple BCC. First, multiple superficial BCC may occur in two generations of a family, with occasional male-to-male transmission. Second, a strictly unilateral involvement was noted in three reports, suggesting mosaicism originating from a postzygotic mutation. In the year 2000, the Happle type of hereditary BCC has got its own OMIM entry #605462. Hence, we fear that in the year 2009, it can no longer be discovered as a new phenotype.