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Identification and isolation of antigenically marked colonies in mouse cell cultures: a technique for detecting genetic changes.

This paper describes a technique by which specific genetic changes involving histocompatability loci in cultured mouse cells can be detected and the altered cells isolated. Reconstruction experiments were carried out using cells from two inbred mouse strains in mixed cultures. These cells were antigenically different and fluorescent antibodies were used to identify cells expressing the desired phenotype in a partially cloned culture. Fluorescing colonies were isolated, recloned, and established as pure cultures. The application of this technique to gene transfer, mutation, and cell hybridization studies is discussed briefly.