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CD95‐Ligand from Myeloid Cells Contributes to Abdominal Aortic Aneurysm Formation

Abdominal aortic aneurysm (AAA) is one of a number of diseases associated with a prominent inflammatory cell infiltration, matrix protein degradation, and smooth muscle cell apoptosis. This chronic infiltrate is predominantly composed of macrophages and T lymphocytes. Active T cells produce a variety of cytokines, including CD95‐ligand (CD95L). Elevated expression of CD95L in the aortic tissue was observed in patients with AAA, suggesting that CD95L may play a role in the pathogenic mechanism of AAA. The purpose of this study was to investigate the role of CD95L in AAA formation. By studying a murine model of aneurysm, we found that both mRNA and protein levels of CD95L were increased in aneurysm tissue compared with normal aortic tissue. We further tested the response of mice lacking expression of CD95L to aneurysm formation. These mice were resistant to aneurysm formation. Our results show that CD95L deficiency attenuates macrophage and T cell infiltration into the aortic tissue. To study the role of CD95L in the myelogeous cells in AAA formation, we created chimeric mice and showed that myelogeous cell‐derived CD95L plays a dominant role in disease progression. These studies demonstrated that inflammatory cell infiltration during AAA formation is dependent on myelogeous cell‐derived CD95L.