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Echogenic foci in the fetal heart: a marker of chromosomal abnormality

in Japanese controls (Hata et al. 1994). Against this allelic background, it is difficult to conduct an association study which avoids cryptic ethnic differences between preeclamptic and control groups. The T235 allele was initially found to be associated with essential hypertension (Jeunemaitre et al. 1992). Although essential hypertension predisposes to pre-eclampsia, the pathophysiologies of the two conditions differ fundamentally : the T235 allele merely may be associated with a subgroup of pre-eclamptic women in whom essential hypertension is a predisposing factor. We are currently accumulating a larger dataset in an attempt to clarify the role of the angiotensinogen gene in the aetiology of pre-eclampsia.