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Crystal structure of human dendritic cell inhibitory receptor C‐type lectin domain reveals the binding mode with N‐glycan

Human dendritic cell inhibitory receptor (DCIR) is a C‐type lectin receptor expressed in classical dendritic cells and accepts several oligosaccharide ligands including N‐glycans. Here, we report the crystal structures of human DCIR C‐type lectin domains in the absence and presence of a branched N‐glycan unit. The domain has a typical C‐type lectin fold and two bound calcium ions. In the ligand‐bound form, the disaccharide unit (GlcNAcβ1‐2Man) acceptably fits the electron density map, indicating that it forms the main epitope. The recognition of the nonterminal N‐glycan unit explains the relatively broad specificity of this lectin.