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GLUT2 polymorphism modifies the intake of dietary carbohydrates in individuals with Type 2 Diabetes

Glucose transporter type II (GLUT2) has been implicated in impaired control of feeding in GLUT2‐null mice, however, the effect in humans is not known. To determine its role in humans, genetic variations of the GLUT2 gene were studied in 109 individuals (54 male, 55 female) with type 2 diabetes, aged 42–75 years, and with a BMI > 25kg/m2. DNA was isolated from white blood cells and subjects were genotyped for the GLUT2 Thr110Ile polymorphism using real‐time PCR. Dietary intake was assessed using 3‐day food records. Dietary intakes between genotypes were compared using unpaired t‐tests adjusted for age, sex and BMI. In comparison to individuals with the Thr/Thr genotype, carriers of the Ile allele consumed higher daily average intakes of carbohydrates (252 ± 67 g vs. 203 ± 69 g, p=0.006), and sugars (103 ± 35 g vs. 81 ± 36 g, p=0.01). However, total calories, protein, fat, alcohol, fiber and the glycemic index did not differ between genotypes. In summary, our results suggest that GLUT2 plays a role in glucose sensing in humans and may explain individual variations in preference for carbohydrate‐rich foods.