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Differential effects of dermatological cream bases with respect to skin surface moisturizing capacity: A study design in volunteers.

The efficacy of creams and ointments on skin surface hydration was assessed in healthy volunteers. The results of two studies showed differential responses to ointments, oil-in-water (o/w) creams and Lipobase (an o/w cream with a high fat content). The present study design is recommended for the easy and reliable preclinical evaluation of topical vehicles.