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Effects of tryptophan and portocaval anastomosis on activity and brain tryptophan metabolism [proceedings].

Chronic portocaval anastomosis in the rat increases brain tryptophan and tyrosine, and thus 5-hydroxytryptamine (5-HT) (Curzon, Kantamaneni, Fernando, Woods & Cavanagh, 1975) and octopamine synthesis anastomosis also showed significantly less ambulation than sham-operated animals, and midbrain tryptophan, 5-HT and 5-HIAA were all significantly raised. Ambulation by anastomosed rats was not significantly decreased further by tryptophan, although midbrain tryptophan and 5-HT (but not 5-HIAA) rose significantly. Ambulation was significantly decreased and all biochemical measures significantly increased in tryptophan-treated anastomosed rats when compared with the sham-operated group given saline. Brain tryptophan rose more strikingly in anastomosed rats than in sham-operated animals given tryptophan. These results are suggestive of an association between raised brain tryptophan, and/or 5-HT turnover, and central disturbances in liver failure.