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MRI of trabecular bone using a decay due to diffusion in the internal field contrast imaging sequence

To characterize the DDIF (Decay due to Diffusion in the Internal Field) method using intact animal trabecular bone specimens of varying trabecular structure and porosity, under ex vivo conditions closely resembling in vivo physiological conditions. The DDIF method provides a diffusion contrast which is related to the surface‐to‐volume ratio of the porous structure of bones. DDIF has previously been used successfully to study marrow‐free trabecular bone, but the DDIF contrast hitherto had not been tested in intact specimens containing marrow and surrounded by soft tissue.