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Evaluation of a new solution containing trehalose for twenty‐hour canine lung preservation

Abstract We examined the efficacy of two new preservation solutions containing trehalose ‐ an extracellular type (ET‐K) of solution and an intracellular type (IT‐K) of solution ‐ in relation to that of Euro‐Collins (EC) solution in 20‐h canine lung preservation. Canine lungs were flushed with one of the three solutions (n= 5 for each solution) after pre‐treatment with PGE, (20 µg/kg) and were stored for 20 h at 4°C. The left lungs were transplanted and evaluated to 6 h post transplant. In the ET‐K group, the arterial oxygen tension after reperfusion was significantly higher than in the IT‐K and EC groups. The pulmonary vascular resistance, wet/dry weight ratio, and histological evaluation of each transplanted lung in the ET‐K group were also better than in the IT‐K and EC groups. This indicates that ET‐K solution is useful for 20‐h preservation of canine lung grafts.