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Dihydrotestosterone and its relationship to testosterone in infancy and childhood.

Abstract A cross-sectional and longitudinal study of the change in dihydrotestosterone (DHT) and testosterone (T) serum concentration was undertaken in infants from birth to 18 months to elucidate the differences in the concentration of DHT and T in male and female infants. In addition, changes in DHT, T, and the T:DHT ratio were studied in males from infancy to adulthood. Both DHT and T in cord blood were significantly higher in male than in female infants (P < 0.005 and P = 0.01, respectively). Postnatally, in male infants, there was a parallel rise in DHT and T to pubertal levels, resulting in a constant T: DHT ratio (mean ± sd, 4.9 ± 2.7). After hCG stimulation, the T: DHT ratio was similar in this age group (mean ± sd, 5.3 ± 1.7). Both DHT and T decreased sharply at age 6 months in young male infants. The T:DHT ratio rose significantly (P < 0.001) in late puberty (mean ± sd, 10 ± 1.9). The T:DHT ratio after hCG stimulation in older male infants and prepubertal boys (mean ± sd, 11 ± 4.4) with varying ...