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Lactic Dehydrogenase Virus Inhibits Allergic Immunoglobulin E Production: In Vivo Molecular Analysis of Cytokines

The effects of lactic dehydrogenase virus (LDV) infection on allergic immunoglobulin (Ig)E production and interleukin (IL)‐4 gene expression were studied. LDV infection suppressed antigen‐induced IgE production in sensitized mice. The elevations of IL‐4 gene expression in spleen and mesenteric lymph nodes 3 and 7 days after ovalbumin challenge were suppressed significantly in LDV‐infected mice compared with control mice. The expression of the interferon (IFN)‐γ gene of mesenteric lymph nodes was significantly increased in LDV‐infected mice. These results suggest that LDV infection suppressed antigen‐induced IgE production by decreasing IL‐4 production, and that suppression of IL‐4 gene expression may be mediated by a mutual inhibition mechanism between T helper (Th)1 and Th2 cells.