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The effects of tonicity on tension and stiffness of tetanized skeletal muscle fibres of the frog.

Tension and stiffness of tetanically activated skeletal muscle fibres of the frog were studied at varied tonicity of the extracellular medium (1.7-3.2 degrees C; sarcomere length, 2.13-2.22 microns). The stiffness was measured from the change in peak tension in response to fast (0.2 ms) stretches and releases of small amplitude (0.11-0.15% of the fibre length). The bathing solution was made hypotonic by reduction of NaCl and hypertonic by addition of sucrose. The osmotic strength of the solutions tested varied from 81 to 168% of the isotonic value. Maximum tetanic tension decreased markedly with increased tonicity. The active stiffness, on the other hand, increased as the tonicity was raised, and the tension/stiffness ratio (the total extension of the undamped fibre elasticity) was thus greatly reduced under these conditions. Evidence is presented to show that the change in the tension/stiffness ratio is due neither to the development of rigor cross-bridges nor to the recruitment of passive parallel-elastic elements in response to increased tonicity. Neither are viscous-like components important for explaining the effect. A change in the tension/stiffness ratio, similar to that seen in response to increased tonicity, did not occur as fibre width was reduced by increasing the sarcomere length. This suggests that the changes in the fibre volume affect this ratio mainly by mechanisms that are unrelated to changes in lateral spacing between the myofilaments.