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OP16.03: Fetal brain ultrasound assessment by Texture Analysis in CMV infected fetuses with and without neurological damage

Objectives: To describe a cohort of fetuses with non visualization of fluid inside the cavum septi pellucidi without callosal agenesis. To discuss the significance of this finding regarding postnatal development. Methods: We reviewed all the files of patients referred because of suspected supratentorial midline anomalies searching for patients with a diagnosis of non-visualization or obliteration of the CSP. Results: From the initial cohort including 114 patients we identified 23 cases. They were referred at a mean gestational age of 24.5 ± 1.3 weeks; the referral diagnoses included: non visualization or an echogenic CSP (18), suspected callosal anomaly (5), other causes (5). The patients were examined for the first time at the FNC at a mean gestational age of 26.6 ± 3.1 weeks (range 22–34 weeks; median 27 weeks). In all the patients the zone where the fluid should have been observed was echogenic. In 17 this was an apparently isolated finding and in 6 it was associated with other findings but only one had associated malformations. Follow-up was available for 16 children at a mean age of 17.4 months (range 4–36 months, median 19.5 months). Fourteen children were developing normally. One had infantile hypotonia but normal developmental milestones; another had mild motor delay and language delay. These two children did not have associated anomalies. Conclusions: Non visualization of fluid inside the CSP is not always associated with ACC and when isolated may be considered a variation of normal development.