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[An optimal method of pharmacological prevention of tuberculosis among adolescents].

The paper presents the findings of a comparative study of the efficacy of chemoprophylaxis which was conducted by the everyday (1 course) and intermittent (2 courses) method in adolescents aged 12-17 years, depending on the presence of aggravating factors. Examination covered 150 adolescents from the VI registration group. Following chemoprophylaxis there was a drop in sensitivity to tuberculin in 95.5 +/- 0.8% of group 1 (main) and in 78.5 +/- 1.1% of group 2 cases during which a medium size of an infiltrate in group 1 reduced by 2.8 mm more than that in group 2 (p less than 0.001). After the end of an observation period, 92.4 +/- 0.8% of subjects of group 1 and 79.4 +/- 0.5% of subjects of group 2 were struck off the register from the VIA registration group; the respective figures for the VIB registration group were 73.2 +/- 0.2% and 58.6 +/- 3%. The epidemiologic and economic effect of chemoprophylaxis conducted by 2 courses was 2 and 1.5 times higher than that in the traditional method.