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Distribution of Type‐I Interferon‐Receptors in Human First Trimester and Term Placental Tissues and on Isolated Trophoblast Cells

PROBLEM: Type‐I interferon (IFN) is the protein recognizing pregnancy in ruminants. Although IFN is secreted in early pregnancy, its role is not still clear in other species. Like other cytokines, IFN exerts its biological functions through specific membrane receptors. We have investigated the potential action of IFN in human pregnancy by studying the distribution of the receptors in the human placenta.