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Is topically applied irradiation with visible and IR light at low fluence rates able to produce systemic effects: literature review and experience

The authors review the literature dealing with systemic effects of low power laser irradiation under tin vitro and in vivo conditions. Additionally, we report on the results of two experiments designed to evaluate the possible systemic effects of topically applied low power laser light. In the first set of experiments, we showed significant changes on pre-immunized rabbits' differential blood count and body temperature after transcutaneously delivered laser light. In the second experimental trial, patients suffering from diabetic angiopathy were treated with laser light. Determination of blood flow by means of IR-thermography revealed significant increases in temperature over the affected region and the non-irradiated contralateral extremity.