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Blood—cerebrospinal fluid transfer of plasma proteins during fetal development in the sheep

1. The penetration of human and sheep plasma proteins from blood into c.s.f. of sheep fetuses (57‐86 days gestation) has been studied. The proteins were injected intravenously via cotyledonary vessels. After different time periods the c.s.f. concentrations of marker proteins were estimated by radioactive counting of iodinated human or sheep proteins or by immunoassay of human proteins.