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[Morphologic signs of adaptation of the microcirculatory bed of the liver to denervation].

The effect of mixed denervation on the hepatic microcirculatory bed was studied in dogs and rats. Seven days after denervation, dilated sinusoid capillaries and spaces around the sinuses (Disse's space), disorders in structure of the sinusoid reticular carcass were revealed in the liver of the dogs and rats. The labelled nuclei index in the stellate endotheliocytes is statistically increasing; one month later, in the sinusoid wall the number of cells containing glicosaminoglicanes in the cytoplasm is increasing, outgrowth of the reticular fibres in the perisinusoid spaces and reorganization of the reticular type of the hepatic stroma from the radial into the alveolar one is noted. All the signs mentioned above demonstrate certain adaptation of the microcirculatory bed in the denervated liver to the altered conditions of hemodynamics.