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Cerebrospinal fluid insulin‐like growth factor (IGF‐1) and insulin‐like growth factor binding protein (IGFBP‐2) in children with acute lymphoblastic leukemia

Insulin‐like growth factor‐1 (IGF‐1) has specific effects on axonal growth and myelination, low CSF IGF‐1 levels being found in some severe neurologic diseases. We studied the levels of CSF IGF‐1 and IGF binding protein‐2 (IGFBP‐2) in children with ALL to find out whether these levels correlated with any of the neurological deficits observed.