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Prediction of MAS Therapy Response in Obstructive Sleep Apnoea Patients using Clinical Data

Mandibular Advancement Splint (MAS) is an oral appliance based treatment to Obstructive Sleep Apnoea (OSA) patients that is only effective for some patients. We present an investigation to predict MAS treatment response in OSA patients. A unique dataset in a large number (n=543 patients) consisting of convenient measurement such as demographic, anthropometric and Polysomnography (PSG) variables was utilised. Treatment Responders were defined as those with ≥50% reduction in Apnoea Hypopnoea Index (AHI) resulting in an AHI of less than 10 after the treatment process. Leaveone-out cross validation results using a Quadratic Neural Network showed an overall accuracy of 63%, with 63% sensitivity and 63% specificity for correctly predicting treatment response which is an improvement on previously published results.