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[Ginger extracts improve renal injury of high fructose-fed SD rats by inhibiting the expression of proinflammatory cytokines].

OBJECTIVE
To investigated the effects of ginger extracts on renal injury in high fructose-fed SD rats and the possible underlying mechanism.


METHODS
Twenty rats were randomly divided into control group, fructose group, 20 and 50 mg/kg ginger extract groups, 5 rats in each group. The general situation and histopathological changes in the kidney of rats were observed. The expressions of monocyte chemokine protein 1 (MCP-1), tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) mRNA were detected by real-time quantitative PCR (qRT-PCR); the levels of MCP-1, TNF-α and IL-6 in supernatant of renal tissue homogenates were assessed by ELISA.


RESULTS
Compared to the control group, the kidney mass and the ratio of kidney-to-body mass significantly decreased in fructose group, accompanied by renal tubular injury. Ginger extracts at 50 mg/kg evidently improved renal tubular injury, suppressed the expressions of renal MCP-1, TNF-α and IL-6 mRNA (P<0.05) and decreased the levels of MCP-1 (P<0.05), TNF-α (P<0.01), IL-6 (P<0.05) in kidney tissue homogenates.


CONCLUSION
The supplement of ginger extracts can improve fructose-induced renal injury, which may be associated with the suppression on the expression of proinflammatory cytokines.