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Natural killer cells: can they be useful as adoptive immunotherapy for cancer?

As part of the innate immune system, natural killer (NK) cells form the first line of defence against pathogens or transformed/cancerous host cells. Recent experimental and clinical data show the possibility of exploiting NKactivity as a cell-based immunotherapy to treat cancer. This review di-scusses the recent knowledge on NK cell biology that has impacted on its development as a treatment for cancer.