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Determination of Cefixime in pure form, in pharmaceutical products and biological samples through fluorescence quenching of Eosin Y.

A simple, economic and validated spectrofluorimetric method has been developed for the assay of cefixime (CFX). The technique relies on the quenching effect of CFX on the fluorescence intensity of eosin Y in the presence of acetate buffer of pH 3.4 produced an ion-pair complex which is measured at 549 nm using excitation wavelength of 300 nm. Reaction influencing factors were cautiously investigated and optimized. The fluorescence quenching value was linear to the concentration of the CFX in the range of 0.2-40 μg/mL through correlation coefficient of 0.992. The calculated limit of detection and quantification were found to be 0.00242 and 0.0080 μg mL-1 correspondingly. The selectivity of the method was confirmed by studying the consequence of excipients and no interference were distinguished. The developed method has been used to determine CFX in marketable products and in biological samples. For the validity of the method, the directives of ICH were applied and percent recoveries obtained were ranged from 95.30 to 102.50 % for pharmaceutical products and from 97.00 to 103.00 for biological fluids.