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Induction of testicular aromatization by luteinizing hormone in mature rats.

The hormonal regulation of testicular aromatization and the intratesticular site of estradiol synthesis was investigated in adult rats. To determine testicular aromatization, cell-free homogenates of whole testes, isolated interstitial tissue, and seminiferous tubules were incubated with [3H]testosterone. 3H-Labeled estrogens were isolated and final identity was established by recrystallization of the product with authentic 17β-estradiol or estrone. No 3H-labeled estrogens could be identified in testicular incubations from saline-treated rats. In contrast, similar incubations from rats treated for 6 days with hCG or LH had the capacity to aromatize testosterone to estradiol. Testicular homogenates from rats treated with 4.4 IU hCG/day synthesized 4.76 pg estradiol/mg protein, which represents approximately 280 pg estradiol synthesized/testis during a 3-h incubation. In incubations of cell-free homogenates of isolated testicular compartments from hCG-treated rats, aromatase activity was demonstrated only i...