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Renal Derived Human sPRR Increases Plasma Osmolality and Aquaporin 2 Expression in Male but Not in Female Mice

Several studies have shown that soluble prorenin receptor (sPRR) plays an important role in fluid and electrolyte balance. In rodent models, water deprivation led to an increase in sPRR in the kidney. Our laboratory previously showed that infusion of mouse recombinant sPRR increased urinary vasopressin but did not change water intake and urine flow rate in female mice. Moreover, a counter regulatory increase in plasma sPRR due to knockdown of prorenin receptor (PRR) in the adipose tissue decreased urine flow rate in both male and female mice. However, there is a gap of knowledge concerning the functional role of locally produced sPRR from the kidney. Additionally, the role of human sPRR in fluid and electrolyte balance has not been evaluated. Therefore, we evaluated the role of renal derived human sPRR in fluid and electrolyte homeostasis.