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Clinico-pharmacological characteristics of opioid drug-drug interactions in cancer patients with chronic pain syndrome

The aimof the review was to analyze published studies on the impact of opioid drug-drug interactions on the choice of analgesic therapy regimens.Material and methods.A systematic literature search was conducted using PubMed, Scopus, Web of Science, and E-library databases.Results.The review showed a clinical significance of pharmacokinetic interactions of opioids with other drugs in cancer pain treatment. The problems of individual choice of analgesics from different groups under conditions of co-morbidity and concomitant medication were discussed to ensure the effectiveness/safety of the treatment strategy affecting the quality of life of cancer patients.Conclusion.A comprehensive assessment of factors in patients receiving opioid analgesics is a predictor of effective and safe analgesic therapy.