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Monitoring of hearing during treatment of leukaemia with special reference to the use of amikacin

Abstract. Thirty‐nine patients with leukaemia were followed audiometrically during treatment with broad‐spectrum antibiotics. Amikacin was given during neutropenic febrile episodes. Five patients reported a deterioration of the hearing function after termination of amikacin treatment. Significant hearing threshold loss occurred in 20 patients (51%). The hearing threshold changes were small in general, except for two patients who exhibited bilateral hearing threshold changes in the frequency range 0.5–8 kHz.