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What’s in a name? Semantic, as well as episodic, memory plays an important role in the diagnostic sensitivity of the free and cued selective reminding test in MCI

The Free and Cued Selective Reminding Test (FCSRT) is highly sensitive in the detection of AD, even at early stages (Grober, et al., 2008; Papp et al., 2015; Slachevsky et al., 2018). By controlling encoding and retrieval, the task is especially sensitive to memory consolidation deficits that characterize AD. During the learning phase, patients name items that are paired with semantic cues aimed to boost encoding and retrieval. However, benefit from the semantic cues requires intact semantic memory and access. As the “cognitive signature” of AD includes reduced semantic processing (Henry and Crawford, 2004.), we asked whether this reduction impacts FCRST performance.