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Effect of Budesonide and Formoterol on Il-6 and Il-8 Release from Primary Bronchial Epithelial Cells

The aim of this study was to explore possible interactions between a glucocorticosteroid (budesonide) and a long-acting β2-agonist (formoterol) on pro-inflammatory cytokine release. Primary bronchial epithelial cells (PBEC) were stimulated with organic dust and incubated with budesonide, formoterol, and the combination of both drugs. Interleukin (IL)-6 and -8 in the supernatant was assessed by enzyme-linked immunosorbent assay (ELISA). Formoterol increased the IL-6 release but did not influence the IL-8 release. Budesonide attenuated the IL-6 and IL-8 release, an inhibiting effect that was sustained, but not reinforced, by formoterol.