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Molluscicidal Activity of Polyacetylenes from Ambrosia maritima Hairy Roots

Thiarubrine A, thiarubrine A epoxide, thiarubrine A diol, and their precursor pentayneene were produced by hairy roots of Ambrosia maritima. The molluscicidal activity of the lipophilic extract of the hairy roots and isolated polyacetylenes were investigated. The activity was studied against Schistosome intermediate host Biomphalaria glabrata. Thiarubrine A diol, the main form detected in the medium, showed the highest activity with LC50 = 0.37 ppm. This activity is 23 times higher than that of ambrosin, a sesquiterpene lactone that has long been regarded as the main molluscicidal agent of the plant. Thiarubrine A diol can be an environmentally accepted molluscicidal agent in areas endemic with schistosomiasis.