{'fraction_non_alphanumeric': 0.029985007496251874, 'fraction_numerical': 0.0074962518740629685, 'mean_word_length': 5.816326530612245, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Spinal 5-HT or NA uptake inhibition potentiates supraspinal morphine antinociception in rats.

Spinal injection of the specific uptake inhibitor of 5-hydroxytryptamine (5-HT), citalopram, or of noradrenaline (NA), desipramine, potentiated the antinociception following intracerebroventricular injection of morphine in rats tested on the hot plate. Combined spinal injection of citalopram and desipramine caused a synergistic potentiation. The unselective and less potent inhibitor of both 5-HT and NA uptake, amitriptyline, did not cause potentiation. The results support the suggested involvement of both 5-HT and NA pathways in supraspinal morphine antinociception.