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Contribution of the antilipid peroxidative action of Dai‐saiko‐to extract to its preventive effect on carbon tetrachloride‐induced acute liver injury in rats

Post‐oral administration of Dai‐saiko‐to extract (TJ‐8), a traditional herbal medicine, ameliorated acute liver injury in rats intoxicated with carbon tetrachloride (CCl4). This TJ‐8 administration inhibited an increase in lipid peroxide contents in the liver homogenate and microsomal fraction and a decrease in glucose‐6‐phosphatase activity in the liver microsomal fraction, an index of lipid peroxidation‐mediated damage in liver microsomes, during the progression and recovery of the liver injury. These results indicate that the antilipid peroxidative action of TJ‐8 contributes to its preventive effect on CCl4‐induced acute liver injury in rats. © 1998 John Wiley & Sons, Ltd.