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Trial registration, the ICMJE statement, and paediatric journals

The risk of wide unnecessary duplication (as opposed to necessary replication) in research, including paediatric research,1 is high. Furthermore, the risk of research findings disappearing from the public knowledge base is especially high for negative trials. Prospective registration of clinical trials should reduce such inadequacies, promote collaboration, facilitate disclosure of information to the public and those involved in health care, and reduce waste of effort and resources.2

The issue has been widely debated in the biomedical journals and many groups have begun to discuss their role in such a matter. In September 2004, the International Committee of Medical Journal Editors (ICMJE), …