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Nanodiscs: A Novel Approach to Studying the Methionine ABC Transporter System

The cell membrane is a formidable yet flexible boundary that separates the interior from the exterior of the cell. The tightly regulated, selective movement of molecules across the membrane is crucial to maintain appropriate intracellular levels of metabolites. Concentrations gradients across lipid bilayers are generated and maintained by specialized integral membrane proteins known as transporters. The long‐term goal of the Yang Group is to understand how transporters catalyze substrate transport across cellular membranes.