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Gestational diabetes may be a risk factor for pancreatic cancer

Gestational diabetes may be associated with pancreatic cancer, according to a new study of Israeli women. This research is the first to link gestational diabetes to pancreatic cancer, although previous research has linked Type 2 diabetes with an increased risk for pancreatic cancer. Mary Pennin, New York University School of Medicine (NY, USA), and colleagues analyzed data on nearly 40,000 Israeli women who gave birth in Jerusalem between 1964 and 1976. Data on the women, who were followed for 28–40 years, revealed that there were 54 cases of pancreatic cancer among these women. Five of these cases were in the 410 women who suffered gestational diabetes during one or more pregnancies. Gestational diabetes preceded diagnosis of pancreatic cancer by 14–35 years. While the absolute risk of pancreatic cancer was very low, women with a history of gestational diabetes had a relative risk of pancreatic cancer of 7.1 (95% confidence interval [CI]: 2.8–18.0). Annually, over 200,000 cases of pancreatic cancer are diagnosed worldwide; 5-year survival rates for pancreatic cancer are very low, due to the fact that it is usually diagnosed at a late stage in development. “What makes this study important is – other than a potential to develop Type 2 diabetes – not much is known about gestational diabetes, which may be an earlier marker of risk of other health outcomes like pancreatic cancer,” explained Perrin.