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Cytoplasmic alterations of hepatocytes in rainbow trout (Salmo gairdneri) induced by cyclopropenoid fatty acids.

Rainbow trout were fed a diet containing 200 ppm of the cyclopropenoid fatty acids, sterculic and malvalic acids, substances that greatly increase the sensitivity of trout liver cells to the carcinogenic effects of aflatoxin B1. After 4 weeks, peculiar cleft-like striations appeared in the cytoplasm of hepatocytes. These alterations became progressively more frequent and marked with continued feeding of the diet. At 8 and 12 weeks, the rough-surfaced endoplasmic reticulum contained many parallel arrays and whorled profiles of membrane material. Concomitant with the development of these cytoplasmic alterations, the activity of glucose 6-phosphatase in liver was decreased significantly and remained thus as long as cyclopropenoid fatty acids feeding was continued. On the other hand, the ability of trout liver to o -dealkylate phenacetin remained unchanged. These results suggest that the effect of cyclopropenoid fatty acids on the endoplasmic reticulum is limited to the rough-surfaced variety.