{'fraction_non_alphanumeric': 0.028156543297326014, 'fraction_numerical': 0.013104303169824685, 'mean_word_length': 5.29654403567447, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Prevalence and Risk Factors for Preprocedural Medication Errors in Patients With Atrial Fibrillation and Atrial Flutter

Perfect adherence to anticoagulant medications is an important aspect of care for patients with atrial fibrillation undergoing cardiac electrophysiology procedures to minimize the risk of stroke. Despite this, adherence remains imperfect as is associated with added cost of additional procedures (e.g., transesophageal echocardiography) and administrative burden. We sought to identify characteristics of such patients and predictors of medication errors at Beth Israel Deaconess Medical Center.


Introduction
The use of anticoagulants in patients with atrial fibrillation (AF) reduces the burden of thromboembolic complications, but adherence in real world populations is suboptimal. The increasing use of direct-acting oral anticoagulants (DOACs), which do not require regular laboratory-based monitoring, has only marginally improved rates of adherence over warfarin, with rates of adherence with DOACs as low as 50% in some studies [1,2].
Certain cardiac electrophysiology procedures, including direct current cardioversion (DCCV), pulmonary vein isolation (PVI), and atrial flutter ablation (AFA), are associated with an increased thromboembolic risk, which is substantially reduced by ensuring perfect adherence to anticoagulation therapy in the 3 weeks preceding the procedure. Failure to so has been associated with a 6.8% rate of systemic embolism after cardioversion compared with 0.8% when there is adequate anticoagulation (P = 0.012) [3].
Because of this risk, non-adherence to anticoagulation pri-or to one of these procedures may necessitate a transesophageal echocardiogram (TEE) to evaluate the possibility of intracardiac thrombus, or the procedure may have to be rescheduled. We sought to understand the rate and predictors of incomplete adherence to anticoagulation prior to procedures for AF and atrial flutter as well as the clinical administrative burden associated with managing these lapses in adherence.

Materials and Methods
We conducted a retrospective cohort study of all outpatient DCCVs, PVIs, and AFAs scheduled at Beth Israel Deaconess Medical Center (BIDMC) over a 1-year period from March 29, 2019 until March 28, 2020. We used billing data to collect components of the CHA 2 DS2-VASc score [4] using select ICD-10 codes as has been previously described [5]. Patients' ZIP codes were used to determine the median income and poverty rate of the patients' areas of residence using publicly available data from the US Census Bureau [6] since socioeconomic status has been shown to be a risk factor for non-adherence [7]. This project was approved by the BIDMC Institutional Review Board and was in ethical compliance with the Declaration of Helsinki. We identified all reported medication problems in the 3 weeks preceding a scheduled procedure, consisting of missed or wrong doses of DOACs and subtherapeutic international normalized ratio (INR) if a warfarin was used. Errors were identified by a team of registered nurses who performed an intake interview with each patient on the day prior to their scheduled procedure. We also recorded the action taken by the responsible physician once a medication problem was discovered: procedure cancellation, addition of a TEE, or continuing with the procedure as scheduled. These correspondences took place via an email distribution list which was monitored to determine the volume of emails pertinent to anticoagulation issues.
Statistical analysis was performed using JMP/14 software (SAS Institute Incorporated, Cary, North Carolina). Comparisons were performed with Fisher's exact test for categorical variables and t-test for continuous variables.

Results
A total of 1,248 relevant outpatient electrophysiology proce- Among patients scheduled for these procedures, there were 140 medication problems affecting 11.2% of procedures. A total of 31% occurred in patients on warfarin and the remainder in patients receiving DOACs. There was no difference in age, body mass index, CHA 2 DS 2 -VASc score, serum creatinine, insurance type, race, or English-speaking status between the two groups. Median income and poverty rate were not different across groups in the residential ZIP codes of the two groups.
There was no difference in the rate of errors among patients taking once-daily DOACS versus twice daily DOACs (P = 0.10).
During the study period, there were an average of 3.1 emails per workday (816 per year), or 0.7 emails per procedure (1,248 procedures) regarding care coordination for medication problems.
Direct costs of add-on TEEs, which would not have otherwise been required in the absence of medication problems, resulted in nearly a half-million dollars in additional charges to payors. There were also indirect costs of administrative care coordination (e.g., email) which remain challenging to quantify.

Discussion
Among patients scheduled to undergo 1,248 procedures at a single center, medication errors related to the required anticoagulation therapy in the 3 weeks prior to the procedure occurred in 11.2% of patients, requiring the addition of TEE in the majority of these patients. Warfarin use was associated with more frequent medication errors than the use of DOACs. Strategies to improve adherence to anticoagulation therapy in this high-risk period are needed.

Limitations
Unlike with warfarin, confirmatory serum testing for DOACs is not routinely available or utilized, possibly leading to underreporting of medication errors in patients taking DOACs; patients' self-report of DOAC adherence may be inaccurate.