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Impaired cerebral autoregulation in acute mountain sickness: incidental yet adaptive?

To the Editor:

Subudhi et al1 recently demonstrated that dynamic cerebral autoregulation (CA) became progressively impaired when volunteers were exposed to the hypoxia of simulated high-altitude, although this was unrelated to the onset of neurological symptoms ascribed to acute mountain sickness (AMS). Although their study describes some important findings, the authors’ interpretation of similar studies conducted by our groups2,3 warrants clarification and provides an opportunity to offer complementary insight into alternative mechanisms.

The authors discuss deficiencies with the design and interpretation of our findings, thus “…making it difficult to draw conclusions regarding …