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Interaction of hemoglobin Siriraj with hemoglobin S: a mild sickle cell syndrome.

Hb Siriraj is a beta chain variant in which beta 7 (A4) Glu is replaced by a lysine. It has been encountered in association with Hb S in a black man from Martinique. Some properties of Hb Siriraj are compared, particularly, with Hb C [alpha 2 beta 26(A3)Glu----Lys], and a study of its in vitro interaction with Hb S is discussed.