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Influence of Age on Cardiovascular Effects of Increased Dietary Sodium and Angiotensin‐converting Enzyme Inhibiton in Normotensive Wistar Rats

Recent studies have shown that increased intake of dietary sodium chloride produces blood pressure‐independent increase in cardiac and renal mass even in young normotensive rats. With advancing age the harmful cardiovascular effects of increased dietary sodium are not so well known. In the present study the influence of advancing age on the cardiovascular effects of increased intake of sodium (control diet, 0.3% and high‐sodium diet, 2.6% sodium in the chow) were examined in young and aged (3 and 18 months old, respectively, at the beginning of the experiment) male normotensive Wistar rats in a six‐week study. Moreover, the potential role of renin‐angiotensin system in ageing during normal and a high‐sodium intake was studied using a pharmacological tool, angiotensin converting enzyme (ACE) inhibitor ramipril.