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Infants with chronic lung disease: predictors of mortality at day 28.

The outcome of infants who were admitted to the neonatal intensive care unit at Liverpool Maternity Hospital between January 1980 and December 1989 and who developed chronic lung disease (n = 242) was determined. Forty-three (18%) died in hospital and 18 (9% of survivors) were discharged with home oxygen therapy. The number of days spent receiving supplementary oxygen significantly correlated with the number of days of ventilatory support received and the inspired oxygen concentration on day 28. Logistic regression analysis revealed that death in the hospital was independently associated with being male, and correlated with the number of days of ventilatory support received and the inspired oxygen concentration on day 28. An equation that predicted the probability of death in infants with chronic lung disease was derived and was validated for infants with chronic lung disease at another center (Nottingham). This equation may be useful clinically and for research.