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Allergic contact dermatitis caused by tetrahydroxypropyl ethylenediamine in cosmetic products

A 35-year-old atopic woman presented with an 8-month history of eczema that had started on the back of both hands and later spread to her forearms, legs, and abdomen. She never wore protective gloves when performing household tasks. Patch testing with the European baseline and rubber series, as well as her own cosmetic products, showed positive reactions to nickel sulfate and palladium chloride (explaining jewellery intolerance), as well as to the hand cream that she had used (Table 1). Patch testing with its ingredients showed a positive reaction to tetrahydroxypropyl ethylenediamine. These results were relevant for the eczematous lesions at the back of the hands and wrists, as the patient had regularly used this hand cream. The more widespread eczema on the forearms