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Calcitonin gene‐related peptide immunoreactivity in prurigo nodularis: a comparative study with neurodermatitis circumscripta

Eight patients with intensely pruritic lesions of chronic idiopathic prurigo nodularis and three patients with neurodermatitis circumscripta were investigated using the indirect immunofluoresence method. Results showed similarities in epidermal hyperplasis but not in nerve proliferation and neuropeptide immunoreactivity. Increased numbers of calcitonin generelated peptide (CGRP) and substance P immunoreactive nerve fibre bundles were detected in specimens taken from prurigo nodularis lesions, but no increased immunoreactivity could be seen in specimens taken from patients having neurodermatitis circumscripta compared to normal skin. The neuropeptides, CGRP and substance P, may be responsible for the intense itching of prurigo nodularis lesions.