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The effect of denbufylline (BRL 30892) on cortical pO2, pH, and microflow in a rat model of focal cerebral ischaemia

The effects of denbufylline (DBF), a novel xanthine derivate, have been investigated in a rat model of focal cerebral oligaemia. In this model a small (15–20 mm2) oligaemic area was produced by occlusion of pial arteries with a diameter of ca. 100 μm. The oligaemic area was characterized by a marked fall in cortical microflow, pO2, and pH, this being indicative of severe impairment of tissue nutrition leading to tissue acidosis. It is considered that the situation in this model may be analogous to that occurring in multi‐infarct dementia (MID) patients. DBF improved cerebral blood flow, enhanced cortical tissue oxygenation, and led to normalization of extracellular pH in the rat model of focal cerebral ischaemia. The results suggest that denbufylline ameliorates microcirculation and metabolism in brain areas affected by infarcts of small arteries.