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Biomolecule Function: No Reliable Prediction from Cell Culture

Many efforts in biochemistry and cell biology are directed towards elucidating the function of biomolecules. The emerging wealth of sequence data from different organisms, including humans, has for the first time allowed the initiation of a systematic approach to study the function of proteins. Moreover, technical advances make it possible to include the functional analysis of secondary gene products like lipids, glycoconjugates and metabolites.