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Developmental competence of porcine genome‐edited zygotes

Genome editing in pigs has tremendous practical applications for biomedicine. The advent of genome editing technology, with its use of site‐specific nucleases—including ZFNs, TALENs, and the CRISPR/Cas9 system—has popularized targeted zygote genome editing via one‐step microinjection in several mammalian species. Here, we review methods to optimize the developmental competence of genome‐edited porcine embryos and strategies to improve the zygote genome‐editing efficiency in pigs.