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Lipoprotein(a) Concentration Increases during Treatment with Carbamazepine

Summary:  Purpose: Treatment with carbamazepine (CBZ) is known to affect apolipoprotein B–containing lipoprotein concentrations in serum. However, little is known about the effects of anticonvulsant drugs (AEDs) on lipoprotein(a) [Lp(a)], although Lp(a) has been characterized as independent cardiovascular risk factor. We investigated prospectively the effect of CBZ on lipoprotein(a) concentration in normolipidemic healthy adults.