{'fraction_non_alphanumeric': 0.029743589743589743, 'fraction_numerical': 0.028717948717948718, 'mean_word_length': 4.951219512195122, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Effect of Tumour Promoter Anthralin on Gamma Radiation and 4-nitroquinoline 1-oxide Induced Genotoxicity in Diploid Yeast

Abstract The potentiating effect of tumour promoter anthralin on gamma radiation and 4-Nitroquinoline 1-oxide (4-NQO) induced gene conversion and back mutation was studied using diploid yeast Saccharomyces cerevisiae D7. Cells were exposed to 20-400 Gy of gamma radiation and plated on media without anthralin or containing 0.05-10 mg/ml of anthralin. In another set of experiments, cells were treated with 0.15-0.5 μM 4-NQO and plated on media without anthralin or containing 0.05-0.5 μg/ml of anthralin. The results indicated that anthralin did not modify gamma radiation induced gene conversion or back mutation. Anthralin, however, was found to enhance 4-NQO induced back mutation but not gene conversion. The enhancement was highest with the lowest concentration of anthralin and it decreased subsequently as anthralin concentration was increased.