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RISK OF RETINAL VEIN OCCLUSION IN PATIENTS WITH PSORIASIS: A Population-Based Cohort Study

Purpose: To investigate the risk of developing retinal vein occlusion (RVO) in patients with psoriasis. Methods: In this retrospective population-based cohort study, 30,198 patients with psoriasis (Psoriasis(+) group) and 30,198 controls without psoriasis (Psoriasis(−) group) between 2001 and 2006 from the Taiwan National Health Insurance Research Database were selected. Results: The incidence of RVO was 1.46 times higher in the Psoriasis(+) group than in the Psoriasis(−) group (3.61 vs. 2.47/10,000 person-years) (adjusted hazard ratio = 1.50; 95% confidence interval = 1.07–2.10) calculated using Cox proportional hazard regression. Age was an independent risk factor for RVO (adjusted hazard ratio: 11.9 for patients 65 years or older vs. 1.00 for those 0–49 years old). In the 65 years or older Psoriasis(+) group, the incidence of developing RVO was 1.97 times higher (95% confidence interval = 1.19–3.26) than in the 65 years or older Psoriasis(−) group. In Psoriasis(+) women, the incidence of developing RVO was 1.82 times higher (95% = 1.05–3.14) than in Psoriasis(−) women. For the subgroup with comorbid hypertension, the incidence of developing RVO was 2.07 times higher (95% confidence interval = 1.22–3.50) in the Psoriasis(+) group than in the Psoriasis(−) group. Conclusion: Psoriasis was significantly associated with a higher risk of developing RVO.