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Biotransformation of methyl mercuric salts in the rat with chronic administration of methyl mercuric cysteine.

Biotransformation of methyl mercuric cysteine after repeated injections for 30 days to rats, was followed by the specific determination of inorganic mercury. The rate of biotransformation was found to be dose dependent, low doses releasing relatively more inorganic mercury than high doses. The kidney content of mercury was dependent on the rate of biotransformation, but the brain content was not affected. The significance of biotransformation for the excretion of mercury at different rates dependent on dose, and for the hazards of brain and kidney damage is discussed.