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Efficacy of different plasma sources in the treatment of thrombotic thrombocytopenic purpura

Plasma exchange (PE) with fresh frozen plasma (FFP) is the treatment of choice for thrombotic thrombocytopenic purpura (TTP). Since TTP patients are exposed to a large number of plasma donors, they would benefit from any additional measure of plasma safety. Several such measures have been implemented but doubts remain as to whether the new types of plasma are as effective as FFP or whether some plasma fraction may be more effective.