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Differential regulation of NOS in kidney and heart of SHR fed high salt diet

Nitric oxide (NO) has the important role in regulation of cardiac and renal structure and function. The aim of the present study was to elucidate the effects of dietary salt excess on the expression of three nitric oxide synthase (NOS) isoforms in the kidney and heart of spontaneously hypertensive rats (SHR) fed high salt diet. Male 8‐week old SHR were given an 8% salt diet (HS; n=7) for 5 weeks; their age matched controls (C; n=6) received standard chow.