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Commentary on Gáspár Jékely's article in EMBO reports, July 2002

In his article, Gaspar Jekely praises the role that chemistry played in elucidating the structure of DNA. Rightly so, I must say, being educated as a chemist myself. However, I believe that some modesty is quite appropriate in this case and I would like to explain briefly why chemistry initially failed to grasp the real nature of DNA.

While reflecting on the sequencing of the human genome, Jekely alludes to ‘Albrecht Kossel's Baustein hypothesis—the idea that large polymers can be built from repeated units of similar nature’. Referring to the reconstruction of proteins in the body from degraded proteins in food, Kossel said in a Harvey lecture in 1911, ‘In order to understand fully the change we must remember that the proteins are composed …