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Spotlight on the April 9 Issue

Microinfarcts are commonly observed in neuropathology specimens. The authors present a statistical analysis indicating that 1 or 2 microinfarcts seen on routine neuropathologic examination, like the aphorism about finding one cockroach in your kitchen, imply hundreds throughout the brain. These findings suggest that brain microinfarcts could be numerous enough to impair neurologic function.

See p. 1365; Editorial, p. 1358

Fifty patients with early Alzheimer disease (AD) and 15 controls underwent a 3-T MRI scan and cognitive assessment. Diffusion tensor imaging–based tractography was used to reconstruct each individual's neuronal networks. Network-based analysis of brain white matter connections provides a novel …