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Hemoglobin H disease complicated iron overload and HLA expression in Chinese.

HLA-A,B antigens were typed in 15 patients with Hemoglobin H disease; 10 of them had iron overloading. No significant HLA antigen specificity was identified to be at risk as compared with 170 controls. However, HLA-A11 was suggested to have significant negative risk, and may have a protective effect. (RR = 0.1, p = 0.0015). It seems that increased iron absorption in Hemoglobin H disease is not genetically associated with idiopathic hemochromatosis and certain HLA antigen expressions.