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Effect of L-carnitine on congestive heart failure in patients on maintenance hemodialysis

AIM: To observe the clinical effect of L-carnitine(L-CN) on the improvement of cardiac function of patients with congestive heart failure on maintenance hemodialysis(MHD). METHODS: Thirty patients aged (63.4±7.5) years and with heart function Ⅲ-Ⅳlevel,who were undergoing MHD, were randomly assigned into control group treated with routine therapy (digitalis,diuretics, vasodilator, ACEI or blocker) and to experimental group with intravenous infusion of 1.0 g/d L-CN injection and 500 g/L glucose (40 mL) after each hemodialysis, 3 months as a course.The tolerance to hemodialysis,carnitine level in plasma, left ventricular ejection fraction (LVEF), left ventricular fractional shortening(LVFS) and cardiac output (CO) were observed, and meanwhile blood routine and biochemical examinations were performed in all patients. RESULTS: After 3-month treatment,the carnitine level in plasma was increased from (30.4±8.0) μmol/L to (126.3±17.4) μmol/L.Compared with those before treatment,heart rate ,systolic blood pressure(SBP), diastolic blood pressure(DBP), LVEF were improved (P0.05) and the levels of erythrocytes, hemoglobin and albumin were promoted(P0.05). CONCLUSION: L-CN might be one of effective assistant strategies to correct cardiac dysfunction for the patients with congestive heart failure on MHD.