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PHYTOCHEMICAL AND ANTIMICROBIAL ANALYSIS OF Dryopteris filix-mas (L.) Schott

The phytochemical constitution and antimicrobial study of a methanolic extract from the Dryopteris filix-mas, an underutilized lower plant, was investigated. The extract was fractionated chromatographically for improved bioactivity against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Klebsiella pneumonia and Candida albicans. Micro-dilution method was employed for the antimicrobial investigation of the crude extract while the chromatographic fractions were subjected to disc diffusion assay. Escherichia coli and Proteus mirabilis were the most susceptible to the crude extract both with MIC 25 mg/ml. The chromatographic fractionation improved the antimicrobial potency of the crude extract as shown by the reasonable increase in the observed zone of inhibition while the GC-MS analysis unveiled the nature of phytochemicals in the bioactive chromatographic fractions. This study, therefore, projects Dryopteris filix-mas as a rich source of phytochemicals with promising potential in antimicrobial therapy.