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Lobular breast carcinoma: a case of rare possible 18F-FDG PET/CT and bone scan false negative.

A patient with diffuse osteosclerotic bone metastases from invasive lobular breast carcinoma is presented with both F-FDG PET/CT and bone scans negative for hypermetabolic lesions. Skeletal metastases were documented by CT and bone marrow biopsy, and high increased CA 15-3 level was recorded. This case report points to the potential risk of false-negative FDG PET and bone scans examination in lobular carcinoma type.