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Racial Differences in Hemodynamic Responses to Lower Body Negative Pressure: The Effects of Capsaicin

Previous work in vitro suggests that capsaicin, the spicy ingredient in peppers, attenuates the vascular response to sympathetic activity (“sympatholysis”), likely mediated through vascular transient receptor potential vanilloid type 1 (TRPV1), and was associated with improved vascular function, though translational studies are needed. Further, given racial disparities in vascular function, and reported racial differences in sensory TRPV1 activity, exploring the potential TRPV1‐related mechanisms underpinning these vascular differences is warranted.