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β‐Arrestin2 Regulates the Differential Response of Cortical and Trabecular Bone to Intermittent PTH in Female Mice

Cytoplasmic arrestins regulate PTH signaling in vitro. We show that female β‐arrestin2−/− mice have decreased bone mass and altered bone architecture. The effects of intermittent PTH administration on bone microarchitecture differed in β‐arrestin2−/− and wildtype mice. These data indicate that arrestin‐mediated regulation of intracellular signaling contributes to the differential effects of PTH at endosteal and periosteal bone surfaces.