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Pathogenesis and Pathogenesis Related Treatment of Acne

Acne is a disease of the second life decade with nearly 100% incidence among both females and males. Acne has an polyetiological background comprized of genetic, racial, endocrine, immunological, environmental, and psychological factors. The polymorphous character of acne ranges from a very mild "physiological" course to a severe disabling acute or chronic inflammatory disease (1). In general, two types of acne have to be considered: 1. an endogenous "natural" type, and, 2. a "non-natural" type provoked by additional endogenous or/and exogenous factors. The target organ in acne is the pilosebaceous follicle. Acne almost exclusively occurs in those areas of the body in which this type of follicle is distributed, in particular, the face, chest, and back. Today, at least four etiological factors are accepted to be responsible for the development and maintenance of acne. These are: a) increased activity of the sebaceous glands, b) disturbed cornification within the piloseba-