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Urodynamic Responses of Juvenile and Adult Cats to Nitric Oxide Donor Administration

The bladder facilitates collection and voiding of urine. While not clearly understood, it is known that nitric oxide (NO) and estrogen (EST) play a role in bladder relaxation. This study examined the role of EST in conjunction with NO to determine if bladder function is similar in juvenile and adult cats, regardless of gender, and if SIN‐1, a NO donor, enhances relaxation of bladder smooth muscle. SIN‐1 was administered to naïve cats, adults (> 12 months old), male (AM) and female (AF), and juveniles (< 6 months old), male (JM) and female (JF). Urodynamic parameters were measured. Plasma EST and urinary nitrite levels were determined in each group. Our results, compared to previous studies, show that although the EST levels differed within groups, levels were inversely related to urinary nitrite. Also, SIN‐1 increased bladder compliance and decreased frequency of spontaneous contractions and magnitude of MVT. AF had the highest levels of EST, while AM, JM, and JF were similar. The data may explain urodynamic effects of EST depletion in postmenopausal women.