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STATE OF HOMEOSTASIS IN RATS WITH THERMAL SKIN BURNS OBTAINED IN THE MIDDLE PERIOD OF PREGNANCY

Background. In modern medicine, the problem of treating thermal skin burns in pregnant women remains relevant due to insufficient research of pathological processes occurring in the body of a future mother suffering from thermal injury. The aim of the research. To assess the state of homeostasis in rats with thermal skin burns in the middle period of pregnancy. Material and methods. An experimental study was carried out on 36 female outbred white rats weighing 250-350 g, which underwent thermal skin burns in the middle period of pregnancy. The processes of lipid peroxidation and the total content of nitrate / nitrites were studied, the oxygen transport function of the blood and the main biochemical parameters of the blood were assessed. Results. Thermal skin burn in rats in the middle period of pregnancy leads to the development of hypoxia, as judged by the decrease in pO2 and SO2 values, as well as a decrease in the affinity of hemoglobin for oxygen. At the same time, oxidative stress develops, and an increase in the content of nitrate / nitrites is also observed, which reflects the dysfunction of the L-arginine-NO system, causing changes in the oxygen-binding properties of the blood and forming a prooxidant-antioxidant imbalance. Changes in the main biochemical parameters of blood confirm the presence of endogenous intoxication. Conclusions. The revealed violations of homeostasis in pregnant rats with thermal skin burns indicate the important role of oxygen-dependent processes in the pathogenesis of thermal injury, which must be taken into account when developing appropriate measures aimed at eliminating violations in this pathology.