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Nonparametric analysis of the two-period two-treatment crossover design

The paper describes a nonparametric model for the analysis of the two-treatment, two-period, four-sequence crossover design. Tests for the equality of treatment effects and for the absence of carryover effects are provided. Some relevant asymptotic results of the proposed tests are obtained and compared with the existing nonparametric and parametric competitors via simulation. It is shown that the proposed tests are comparable to or better than the competitors in terms of type I error and power.