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Effect of thyrotropin‐releasing hormone on neuroventilation in bullfrogs

Thyrotropin‐releasing hormone (TRH), a peptide hormone that is found in all classes of vertebrates, is also synthesized in brainstem raphe neurons and may exert direct excitatory actions on ventilatory‐related neurons. The role of TRH as a neuroventilatory stimulant in amphibian species has received little attention. Neuroventilation and neuroventilatory responses of the in vitro en bloc bullfrog tadpole brainstem have been well characterized, and serve as an excellent model for assessing potential modulators of amphibian neuroventilation. TRH (0.1– 10μM) was bath applied to the in vitro en bloc brainstems of early‐stage tadpoles. Bath application of TRH increased the frequency of both lung and buccal bursts. These data indicate that TRH modulates activity in the amphibian ventilatory control network and may suggest functional homology of the amphibian and mammalian networks. Funded by NIH‐NINDS 2U54NS041069‐06A