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Hemodynamic effects at rest and during exercise of long-term sodium restriction in mild essential hypertension.

During moderate sodium restriction for 9 months in 19 men (33 years) with previously untreated mild essential hypertension (EH) sodium excretion fell from 209 to 139 mmol/24 h. Concomitantly intraarterial pressure at rest sitting fell from 145/93 to 138/88 mmHg (5%) and during 100 W exercise from 168/90 to 162/86 mmHg (4%). The fall in BP was due to reduction in cardiac output (5-11% at rest and during exercise) while peripheral vascular resistance was raised (4-10%). Thus, moderate sodium restriction was not very efficient treatment in our patients with mild EH. The main hemodynamic disturbance of established EH--an increase in vascular resistance--was not normalized after 9 months of low salt diet.