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[Application of local drug delivery system to periodontal therapy. 2. Effects of local application of the collagen film immobilized tetracycline].

Tetracycline-immobilzed cross-linked collagen film ( TC film) or tetracycline-non-immobilized placebo film was localy applied four times by weekly to 33 teeth with periodontal pockets larger than 4 mm in 11 patients with periodontal diseases. The clinical and microbiological effect are summarized, as follows In the group treated with the TC film, (1) clinical indices were significantly decreased at the 4th and 7th weeks in comparison with thost at the beginging of treatment. In particular, this group showed a significant decrease in the incidence of bleeding and in gingival index as compared with the placebo group at the 4th week. (2) Total counts of bacteria in periodontal pockets showed an obvious tendency to decrease with time. The proportions of black-pigmented bacteroides and spirochetes in total bacteria were significantly decreased at the 4th and 7th weeks when compared with that at the beginning of treatment. The extent of decrease in the proportion of spirochetes at both the 4th and 7th weeks was more significant compared with placebo group.