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Systematic literature review investigating whether methotrexate causes chronic pulmonary fibrosis

Methotrexate is a treatment widely used in many medical conditions. It is highly effective especially in conditions such as rheumatoid arthritis (RA) and psoriasis. Methotrexate is associated with a potentially fatal acute methotrexate pneumonitis. In regards to chronic lung complications, three case reports with a total of four patients have suggested a link between methotrexate and chronic lung fibrosis.1–3 Subsequent longitudinal studies have refuted this claim.4,5 The aim in this study is to undertake a systematic literature review to evaluate the published evidence on whether methotrexate causes chronic interstitial pulmonary fibrosis in humans. …