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[Effects of substance P on the contractile response of longitudinal muscle of rat ileum to 5-HT].

The purpose of this study was to observe the effects of substance P (SP) on the contractile response of longitudinal muscle with myenteric plexus (LM-MP) of rat ileum induced by 5-HT in vitro and to analyse its mechanism. The results were as follows: (1) Subthreshold dose of SP (5 nmol/L) potentiated the 5-HT-induced contractile response; (2) Both [D-Pro2 D-Trp7,9]-SP and atropine inhibited or blocked this potentiated effect suggesting that the effect was mediated by SP receptors; (3) This effect was not blocked by bromolysergic acid diethylamide (BOL). The results suggest that SP of subthreshold dose might modulate the effect of 5-HT, and a cholinergic mechanism might be involved in the modulation.