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Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type, With Bilateral Intraocular Involvement and Infiltration to the CNS.

Introduction Primary cutaneous diffuse large B-cell lymphoma, leg type (pcDLBCL-LT) is one of the main subtypes of primary cutaneous B-cell lymphoma (pcBCL) that mostly affects elderly women and a has a less favorable prognosis. Histologically, it usually is described as cohesive infiltrates of large B cells with round and prominent nuclei resembling centroblasts and immunoblasts. Unlike other cutaneous lymphomas, pcDLBCL are more likely to disseminate to other organs including the CNS but an infiltration of the tumor to the vitreous is rare. On the other hand, primary intraocular lymphomas are more commonly diffuse large B-cell lymphoma (DLBCL) with vitreoretinal involvement versus secondary intraocular lymphomas which are predominantly observed in the course of systemic and, less frequently, in cutaneous T-cell lymphomas. Secondary intraocular lymphomas usually present with clinically evident choroidal involvement. Here we present a rare case of pcDLBCL-LT with bilateral intraocular involvement and infiltration to the CNS and review the literature.