{'fraction_non_alphanumeric': 0.02240325865580448, 'fraction_numerical': 0.0, 'mean_word_length': 5.597315436241611, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Progress in reversible ADP- ribosylation modification in DNA damage repair and cancer treatment

Cellular genomic DNA is attacked by various internal and external stimuli, inducing multiple types of DNA damage. DNA damage response (DDR) can hastily repair DNA damage, maintain genome stability, and avoid tumors and other diseases. DDR is regulated by diverse protein posttranslational modifications. ADP-ribosylation is one of the most important modifications in DDR. ADP-ribosylation is a dynamic and reversible posttranslational modification. The dynamic balance between ADP-ribosylation and de-ADP-ribosylation precisely regulates DDR. Given the unique function of ADP-ribosylation in DNA damage repair, inhibitors targeting this reversible process have been developed and are expected to be a new class of chemotherapeutics for cancer treatment. This review introduces the research progress of reversible ADP-ribosylation modification in DNA damage repair and cancer treatment.