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Developmental Programming of Glomerular Podocyte Endowment

A range of perturbations to the maternal environment result in low nephron endowment in offspring, which is often linked to increased blood pressure and renal pathology in later life. Given that nephrogenesis in mammals ends shortly before or after birth, this nephron deficit is permanent. To date, very few studies have examined the morphology of nephrons in offspring born with low nephron endowment. Given the link between podocyte loss and glomerulosclerosis in adults, we examined whether maternal perturbations also result in low podocyte endowment in offspring, thereby rendering offspring at increased risk of adult disease.