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Mathematical modelling of energy and redox metabolism of G6PD-deficient erythrocytes.

A mathematical model aimed at the study of erythrocyte metabolism under normal conditions and under glucose 6-phosphate dehydrogenase (G6PD) deficiency has been developed. The degree of deficiency as predicted by the model on the basis of calculated upper limits of oxidative load as well as of maximal methylene blue stimulation correlates with the individual clinical manifestation of the metabolic disease. Therefore, the model permits to judge the degree of metabolic disorder in the presence of G6PD enzymopathies if the kinetic properties of the defect enzyme are known. Experimentally accessible parameters for an assessment of the oxidative load capacity of cells in vivo are proposed. Furthermore, the model predicts that the threshold of tolerance as to energetic load is drastically reduced in the case of severe G6PD deficiency.