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Investigating the role of protein O‐fucosyltransferase 1 in Toll‐like receptor signaling (1004.6)

Protein O‐fucosyltransferase 1 (Pofut1) adds fucose to the serine or threonine residues in the consensus sequence C2‐X(4,5)‐[S/T]‐C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. The most widely studied Pofut1 substrate is Notch, and the modification is essential in many developmental events involving Notch signaling, such as the development of the nervous system, myelopoiesis and lymphopoiesis, and later T‐cell and B‐cell development. It has not been, however, previously implicated in innate immune signaling.