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Is ketamine effective and safe for treating acute pain in hospitalized patients?

Yes. In postoperative patients, ketamine (IV bolus or infusion) moderately reduces total opioid use and time to first analgesic. Symptoms of postoperative nausea and vomiting are also reduced from 30% to 26% with addition of ketamine, although it does increase the risk of neuropsychiatric side effects from 5.0% to 7.3% (SOR: A, meta-analysis of randomized control trials). Ketamine can be used in patients who are undergoing painful procedures, specifically abdominal, thoracic, or orthopedic surgeries associated with severe postoperative pain (SOR: C, expert opinion). Copyright © 2020 by Family Physicians Inquiries Network, Inc. DOI 10.1097/EBP.0000000000000963