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[Coronary circulation-derived plasma in patients with vascular restenosis stimulates the growth of coronary artery smooth muscle cells in culture].

To clarify the role of locally secreted humoral factors in coronary restenosis after percutaneous transluminal coronary angioplasty (PTCA), we studied the effects of coronary circulation-derived plasma from patients with and without restenosis on the growth of coronary artery smooth muscle cells (CASMC) in culture. Specific coronary plasma-dependent growth stimulation/inhibition of cells (CASMC and human umbilical venous endothelial cells) was estimated by subtracting the stimulatory activity, determined by bromodeoxyuridine incorporation, of the pre-coronary plasma from that of the post-coronary plasma. Coronary-specific plasma from five patients with restenosis showed a stimulatory effect on the growth of CASMC, whereas that from four patients without restenosis showed an inhibitory effect. On the other hand, they showed the opposite effects on the growth of endothelial cells. These findings suggested that the local environment is closely associated with the development of restenosis and may play a crucial role. Analysis of coronary circulation-derived plasma may facilitate clarification of the mechanism of restenosis.