{'fraction_non_alphanumeric': 0.0525, 'fraction_numerical': 0.0475, 'mean_word_length': 4.379032258064516, 'pattern_counts': {'":': 0, '<': 10, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Human Atrial Natriuretic Peptide in Aortic and Coronary Sinus Blood During Atrial Pacing in Patients with Ischemic Heart Disease

Summary: This study investigated the plasma concentrations of human atrial natriuretic peptide (hANP) of blood samples obtained from the aorta and coronary sinus (CS) in 19 male patients (mean age of 52.8 ± 2.1 years) with ischemic heart disease before and during atrial pacing. The plasma concentrations of hANP were measured by radioimmunoassay, and the secretion rate of hANP was calculated on the basis of the CS-aorta difference in plasma hANP concentration and the CS flow rate recorded at blood sampling. Before atrial pacing, aortic plasma hANP concentration showed a significant positive correlation with mean pulmonary capillary wedge pressure (r = 0.67, p < 0.002) or mean pulmonary artery pressure (r – 0.71, p < 0.001), and a significant negative correlation with left ventricular ejection fraction (r = −0.50, p < 0.05). During atrial pacing, aortic plasma hANP concentration increased from 67 ± 13 (SEM) to 151 + 33 pg/ml (p < 0.01), CS plasma hANP concentration from 727 ± 121 to 1205 ± 228 pg/ml (p < 0.01), and the hANP secretion rate from 45.4 ± 14.8 to 86.8 ± 28.2 ng/min (p < 0.05, n = 12). The aortic plasma hANP concentration was significantly correlated with the CS plasma hANP concentration (r = 0.81. p < 0.001) or the hANP secretion rate (r = 0.70, p < 0.001). When the patients were divided into the old myocardial infarction group (n = 10) and the angina pectoris group (n = 9), the aortic plasma hANP concentration was significantly higher in the former than in the latter before pacing (p < 0.05). The change in aortic plasma hANP concentration during pacing was significantly smaller in the infarction group than in the angina group (p < 0.05). These results suggest that the secretion rate of hANP determines the circulating level of hANP at rest and during atrial pacing and that the secretion of hANP is influenced by cardiac function.