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Role of brain epinephrine neurons in the regulation of serum prolactin and luteinizing hormone release in female rats.

Administration of phenylethanolamine N-methyltransferase (PNMT) inhibitors to estrogen (EB)-plus progesterone (PG)-treated ovariectomized (OVX) female rats produced significant reductions in hypothalamic epinephrine (Epi) levels and serum luteinizing hormone (LH) levels, but no effect on serum prolactin (Prl) levels. These results suggest that brain Epi neurons may participate in the regulation of LH release but not in controlling the surge of Prl induced by EB-plus PG-treatment in OVX rats.