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The influence of pelvic irradiation on the formation and function of the human corpus luteum.

Evidence is presented that in humans luteinization of granulosa cells and of theca cells and hormone secretion by the corpus luteum were not impaired by radiation doses sufficient to permanently eliminate the estradiol secretion of ovarian follicles. Hormonal changes were monitored in a 29-year-old patient undergoing radiotherapy for cancer of the cervix uteri. The patient ovulated after receiving a radiation dose of 11000 rad to the pelvic region. Ovulation was followed by the formation of a mature corpus luteum despite continuing radiation up to 3000 rad. Progesterone reached levels exceeding 5 ng/ml which is normal for the luteal phase. Estradiol showed a rapid increase in secretion during the follicular phase. Reaching a peak value of 250 pg/ml followed by a decline and then a rise as the corpus luteum matured. This was similar to normal cycles. Follicle stimulating hormone and luteinizing hormone after Day 7 were increased. Lack of maturing follicles later caused disappearance of corpora lutea.