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Venous blood provides lower glucagon‐like peptide‐1 concentrations than arterialized blood in the postprandial but not the fasted state: Consequences of sampling methods

What is the central question of this study? Glucagon‐like peptide‐1 (GLP‐1) is an important obesity/diabetes target, with effects dependent on circulating GLP‐1 concentrations. Peripheral tissues extract GLP‐1; therefore, sampling venous versus arterialized blood might provide different GLP‐1 concentrations. This study examined whether arterialization alters GLP‐1 concentrations during fasting and feeding. What is the main finding and its importance? This study demonstrates that venous blood provides lower postprandial but not fasting GLP‐1 concentrations versus arterialized blood. Therefore, when accurate assessment of postprandial peripheral availability of GLP‐1 is required, blood sampling methods should be considered carefully, reported clearly, and arterialization is recommended.