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Gastrointestinal Pathology: Poster#133 IS COLORECTAL BIOPSY NECESSARY IN IRRITABLE BOWEL SYNDROME?

Background: Clinical symptom based criteria for IBS is not sufficient enough to rule out microscopic colitis (MC). We sought to study whether biopsy is necessary in IBS. Methods: This prospective study included colonic mucosa of 197 patients with IBS (129 IBS-D, 50 IBS-C and 18 IBS-M) to rule out MC. Results: : Overall prevalence of MC in patients with IBS was 23.4% (46/197). The prevalence of MC in patients with IBS-D was 28.7% (37/129), higher than in patients with IBS-C 12% (6/50) and IBS-M 16.7% (3/18). Conclusions: : Microscopic colitis is present in a relevant proportion of symptomatic patients meeting diagnostic criteria for IBS. Despite the fact that IBS is a functional disorder, in many patients morphological changes occur in colon mucosa. The diagnostic criteria of IBS are not specific enough to exclude the presence of MC. Therefore, in patients of IBS, it may be reasonable to perform a biopsy to screen for MC.