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Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase‐activated receptor‐2

Allergy to the German cockroach (Blattella germanica) is a significant asthma risk factor for inner‐city communities. Cockroach, like other allergens, contains trypsin‐like enzyme activity that contributes to allergenicity and airway inflammation by activating proteinase‐activated receptors (PARs). To date, the enzymes responsible for the proteolytic activity of German cockroach allergen have not been characterized.