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Peripheral Arterial Insufficiency: A Study of Prevalence and Factors Associated with Complications in Baja California Sur

Background: Changes in the hygienic and dietary habits of population have favored an increase in peripheral arterial disease (PAI). It has a global prevalence between 3-10%; although, this number has increased to 15-20% in the last years. PAI is a disease characterized by stenosis of arterial lumen causing haemodynamic changes at arterial blood flow level with reduction in perfusion pressure and tissue damage. Aim: So the purpose of this study is to determinate prevalence and factors associated to complications in patients with peripheral arterial insufficiency in Baja California Sur, Mexico. Design and Setting: Comparative cross-sectional study. Methods: In 156 patients with peripheral arterial insufficiencyduring 2015- 2016 in General Hospital Zone #1, La Paz, Baja California, Mexico; prevalence of PAI was calculated. There were two groups (with sequels/without sequels) based on presence of sequels of PAI; it was used 80% statistical power and 95% interval confidence; association was established by calculating odds ratios, chi-squared and Student T test for statistical significance (p<0.05). Results: 61% were men, mean age 65.6 years (±13.3). The association between PAI sequels and comorbidities reported the following results: age [p 0.32], gender (man) [p 0.23], Chronic Renal Failure (with CRF) [p 0.05], Diabetes Mellitus (with DM) [p 0.42], Arterial Hypertension (With AH) [p 1.0], Dyslipidemia (with DL) [p 0.49] and Smoking (With SM) [p 0.45]. When comparing PAI sequels with type of treatment, we found the following: treatment (conventional surgical) [p 1.0], treatment (bypass) [p 0.3] and treatment (angioplasty) [p 1.0]. PAI prevalence was 6.2%. Conclusion: Prevalence of PAI founded is similar to reported in national information; however the prevalence of complication or sequels is higher than reported in other cities of Mexico.


Introduction
In recent years amputations have increased in Mexico and in the world secondary to advanced occlusive vascular disease. Approximately 10% of Mexican population has Diabetes Mellitus (DM), an important risk factor for the development of peripheral arterial insufficiency [1]. Occlusive peripheral arterial disease occurs in 3 to 10% of the world's population, although this disease increases considerably in people over 70 years (15% to 20%) [2]. Risk factors such as smoking, type 2 diabetes mellitus and dyslipidemia should be strictly controlled to delay atherosclerotic process in peripheral vessels [2]. Related symptoms may range from pain on walking to presence of a chronic ulcer that does not heal properly [1].
Symptoms may occur in 3 forms: intermittent claudication, critical ischemia and acute arterial insufficiency; intermittent claudication and presence of critical ischemia are associated with vascular events such as myocardial infarction or cerebral infarcts. It

Research Article
Peripheral type of patients and offers the best alternative [1]. Indication of surgical treatment (conventional or endovascular) will depend on joint assessment of two fundamental aspects, clinical situation of patient and vascular territory that needs reconstruction. The clearest indication for revascularization is a patient with advanced stages of ischemia and a high risk of limb loss [6].
Ankle-arm index (AAI) and finger-arm index (FAI) allow diagnosis of this disease, being used as cardiovascular risk markers. Oscillometry, segmental pressures and spectral analysis of doppler curves are mainly used to know location of disease; all these are hemodynamic explorations. Morphological, echo-doppler (also contributes hemodynamic information), computed tomography, magnetic angioresonance and arteriography, give more precise information on location and characteristics of the lesions [7]. Based on the above, main objective of this study was to determinate prevalence and factors associated to complications in patients with peripheral arterial insufficiency in Baja California Sur, Mexico.

Materials and Methods
A comparative, cross-sectional study was carried out in the General Hospital Zone #1 of the Mexican Institute of Social Security (IMSS) in La Paz, Baja California Sur, Mexico, from March 2015 to March 2016. All medical records of patients in angiology department were reviewed and information was collected of patients that met the following inclusion criteria: any gender, older than 18 years and diagnosis of PAI and were eliminated those who did not have complete information. The following data were obtained directly from the medical records: age, gender, diagnosis of PAI, type of treatment, complications of PAI, squeals of PAI and comorbidities or chronic degenerative diseases as Diabetes Mellitus (DM), Chronic Renal Failure (CRF) and arterial hypertension (HA).
The data obtained was integrated into data collection sheets and analyzed using the SPSS program version 20 in Spanish, where we applied descriptive statistics; for qualitative variables frequencies and percentages were used and for quantitative variables mean and standard deviation were used. For bivariate analysis was considered statistically significant a p <0.05, with a 95% confidence interval, all variables were dichotomized to apply odds ratio and chi square, for quantitative variables student T was used. The Protocol was authorized by the Local Committee of Research and Ethics in Health Research from the General Hospital Zone#1, where the study took place.

Discussion
In research study we found in angiology department a total of 2108 consultations during the months of March 2015 to March 2016. With data obtained, prevalence of peripheral arterial insufficiency was 6.26% which is similar to reported by Alzamora et al in Spain    very frequent in patients with renal insufficiency and there is a strong association with the wrist-ankle index so it is considered important to detect asymptomatic patients [9] which is similar to that found in our study where there was an association between presence of complications due to arterial insufficiency and chronic renal failure (p 0.05).

Conclusion
In this research it is concluded that during March 2015 to March 2016 a total of 156 patients with a diagnosis of peripheral arterial insufficiency were found, with a frequency similar to reported in international literature. A total of 33 patients with amputation secondary to PAI were found with a prevalence of 21.2%, which is alarmingly high and different from what was reported at national level in Mexico; the development of other lines of investigation that allow us to know risk factors that influence for presenting complications in patients with PAI must be implemented.