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Alumina cream‐induced Focal Motor Epilepsy in Cats

The histopathological characteristics of epileptogenic lesions produced by single microinjections of alumina cream (AC) were serially studied in brains of 18 cats sacrificed during the latent, convulsive and remission stages of the spontaneous course. In addition, the thickness and cellularity of the cerebral cortex were measured quantitatively at four cortical sites: cortex adjacent to lesions (right anterior sigmoid gyrus), ipsilateral cortex 1.5 mm away from lesions (right anterior limbic area), and homologous contralateral cortices. Data from alumina cream animals were compared with those obtained from equivalent cortical regions of animals with non‐epileptogenic lesions produced by silicon and of controls (craniotomy and dural flap but no lesion).