{'fraction_non_alphanumeric': 0.019148936170212766, 'fraction_numerical': 0.0031914893617021275, 'mean_word_length': 5.401360544217687, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Can “blue” genes affect mood and movement?

In this issue of Neurology , Heiman et al. present data linking early-onset recurrent depression with the DYTI gene mutation known to underlie most cases of autosomal dominant idiopathic torsion dystonia (ITD).1 The authors use an imaginative research design to compare the rates of depression in three groups: DYTI carriers with dystonia, DYTI carriers without dystonia, and noncarriers. By demonstrating a significantly higher rate of depression in carriers than noncarriers, they conclude that carrier status confers an increased risk of developing depression. By demonstrating equivalent rates of depression in DYT1 carriers with and without dystonia motor symptoms, they conclude that comorbid depression is an expression of the DYT1 mutation and is not simply the expected consequence of an individual with a disabling neurologic disorder.

These findings further support the link between …