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Circadian changes of influence of swallowing on heart rate variability with respiratory-phase domain analysis

Respiratory sinus arrhythmia (RSA) is known as an index of cardiac vagal activity and useful to evaluate the response of the cardiovascular system to external stimuli. As an external stimulation, swallowing is known to strongly affect the cardiovascular system. However, the influence of swallowing and its relation with the autonomic nervous system remain incompletely understood. In this study, since autonomic nervous control of the cardiovascular system has a circadian rhythm, we evaluated circadian changes of influence of swallowing on RSA. Measurements were conducted on healthy humans with periodic swallowing in the morning, afternoon, and evening. RSA waveforms were extracted from an instantaneous R-R Interval (RRI) as functions of the respiratory phase and the data were divided into three subsets with respiration with swallowing, one respiration after the swallowing, and normal respiration. As a result, the RSA amplitude during respiration with swallowing was larger in the morning than in the evening. In addition, the minimum RRI during respiration with swallowing was larger in the morning than in the afternoon and evening. Thus, circadian changes of influence of swallowing on the RSA amplitude are extracted and swallowing-induced tachycardia is different with different states of autonomic nervous activity. Therefore, vagal activity should largely contribute to tachycardia induced by swallowing and evaluation of circadian changes of influences of external stimuli would be useful to investigate the mechanisms of response of the cardiovascular system to external stimuli.