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Corticotrophin and vasopressin responses to metoclopramide in patients with hypothalamic amenorrhoea

OBJECTIVE A dopamine (DA) antagonist, metoclopramide, stimulates ACTH secretion in some women with hypothalamic amenorrhoea (HA) but not in normal women. Metoclopramide may stimulate ACTH secretion by decreasing dopaminergic inhibition of ACTH release. Furthermore, metoclopramide stimulates AVP secretion, and AVP is a stimulator of ACTH. Therefore, AVP may also be involved in the ACTH responses to metoclopramide. The relation between AVP and ACTH responses to metoclopramide were evaluated in normal women and women with HA to obtain more insight into the role of DA in the regulation of ACTH and AVP secretion.