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Cardiovascular Molecular Biology: Introduction to the Series

Aprecise understanding of the molecular mechanisms that control the function of the cardiovascular system has remained an elusive goal. As a result, medical therapy has often been based on empirical observations rather than on the fundamental mechanisms of cardiovascular dysfunction. The judicious application of molecular biology and related techniques holds great promise for the study of important clinical and experimental problems in cardiovascular medicine. Recent studies have successfully used molecular techniques to begin to unravel complex biological problems that have direct relevance to cardiovascular research problems, such as the control of cell growth and proliferation, the structure-function relations of membrane receptors and other critical cellular proteins, and the large-scale isolation and purification of proteins with potential therapeutic value, such as human insulin and tissue-type plasminogen activator (t-PA). In addition, rapid advances in the isola-