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Perioperative COX‐2 inhibitors may increase the risk of post‐operative acute kidney injury

In enhanced recovery protocols (ERP), a restrictive fluid regimen is proposed. Patients who undergo major surgery have an increased risk of post‐operative acute kidney injury (AKI). This combination may pose difficulties when ERP is used for patients undergoing major surgery. The aim of this study was to evaluate whether patients undergoing pancreatic surgery and treated with a restrictive fluid regimen are at greater risk of post‐operative AKI. Furthermore, if there was an increased risk of AKI, we aimed to identify its cause.