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[The study of biocompatibility of titanium in middle ear cave of guinea-pig].

In order to supply full objective basis about tympanoplasty with titanium, 30 middle ear caves of guinea-pigs were implanted titanium ring in accordance with different time groups. Both before and after titanium ring were implanted, the guinea-pigs were detected in biochemical criterion of blood, titanium content of the hair, the changing of auditory threshold, tissue structural of middle ear and inner ear by energy spectrometry, electro-physiology, microscopy and scanning electron microscopy. The results showed that function of hepatorenal and titanium content of hair haven't significant change between pre- and postimplantation of titanium ring. Only 10 days group, it appeared the rising of auditory threshold and inverting of cilia by ABR and scanning electron microscopy. In 10 days and 1 month groups, there were blood stain and inflammatory cells under mucosa. The results suggested that titanium is good biocompatibility and no toxic for organism and mucosa.