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Peracute disseminated fatal Aspergillus fumigatus sepsis as a complication of corticoid‐treated systemic lupus erythematosus

Summary. Immunocompromised and granulocytopenic patients and those receiving long‐term or high‐dose coiticoid treatment are predisposed to disseminating Aspergillus infections. However, Aspergillus infection has been described only rarely in patients with autoimmune diseases. We report on a woman suffering from systemic lupus erythematosus treated by antibiotics and high‐dose corticosteroids, a primary risk factor, who developed a peracute disseminated fatal Aspergillus fumigatus infection involving the central nervous system. The present case is compared with 10 previous reports of invasive aspergillosis in systemic lupus erythematosus found by a literature search.