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Enhance intestinal lymphatic transport of lipophilic bioactive food components by nanoemulsion delivery system (1044.16)

One way to enhance bioavailability of lipophilic nutraceuticals is to facilitate their intestinal lymphatic transport. We studied the effects of triglycerides‐based nanoemulsion delivery systems with different fatty acid chain lengths on the intestinal lymphatic transport of a highly lipophilic flavonoid, 5‐demethylnobiletin (5DN). 5DN was encapsulated in medium chain triglycerides (MCT) or long chain triglycerides (LCT) based nanoemulsions. These systems were subject to a simulated gastrointestinal digestion model. The resulted mixed micelle phase that contained bioaccessible portion of 5ND was applied to Caco‐2 monolayer cell model that mimics intestinal absorption. We observed that 30% of 5DN underwent intestinal lymphatic transport when 5DN was encapsulated in LCT‐based emulsion, while only 5% of 5DN underwent intestinal lymphatic transport in case of MCT‐based emulsion. Moreover, much more Apo B protein was secreted in the enterocytes by the stimulation of the digesta produced from LCT‐based emulsion in comparison to MCT‐based emulsion. This suggested more chylomicrons were formed in the enterocytes as the result of digestion of LCT‐based emulsion. In conclusion, we demonstrated that LCT‐based emulsion was more potent in enhancing the bioavailability of lipophilic components through increased lymphatic transport in comparison to MCT‐based emulsion.