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Infertility and pregnancy in patients with APECED: more than just primary ovarian failure?

With the recent advances in the diagnosis and management of primary immune deficiencies, more women suffering from these ailments are healthier and willing to start a family in their childbearing years. Unfortunately, the literature on fertility and pregnancy outcomes in such patients is scarce and there are no clear guidelines regarding pre-conceptual care or management during gestation. Since reproductive outcomes are probably dependant on the underlying monogenic disorder, enhanced reporting of such cases is crucial to guide patient care and our understanding of the immune system's involvement in conception and pregnancy. This article is protected by copyright. All rights reserved.