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Postprandial glycaemic responses in pre- and post-menopausal women

Postprandial hyperglycaemia increases diabetic and cardiovascular disease risk in healthy individuals (1) . Co-ingesting vegetables with high carbohydrate meals can attenuate postprandial glycaemic responses (GR) (2) . This study aims to further investigate the effect of age and menstrual status on postprandial GR in pre- and post-menopausal women. Eighteen, pre- (n = 7) and post-menopausal (n = 11) women (BMI 25.2 – 30.4 kg/m 2 ) have been recruited to The impact of Vegetables on acute glycaemia and Glycaemia induced CVD risk in women: metabolic effects and Inter-individual variations study (VegGI). Postprandial GR following rice (75 g of available carbohydrate) (R), rice with bok choy (150g) (RB) or spinach (150g) (RS) was measured every 5 minutes for 4 hours using a Continuous Glucose Monitoring system (Medtronic Ltd). Anthropometric, cholesterol (Cholestech LDX, Alere) and HbA1c (A ﬁ nion AS100, Alere) measures were made in a fasted state. Oestradiol, progesterone, follicular stimulating hormone (FSH) and testosterone were measured (ADVIA Centaur). Principal compo-nent analysis (PCA) (Umetrics SIMCA-P + 12.0) was performed on GR data. Total GR was expressed as the incremental area under the curve (iAUC) and calculated geometrically. A linear mixed model was used to analyse the impact of R, RB, RS on GR using age and diet as factors. Independent samples t-test was used for further data comparisons (ver.24.0; SPSS Inc). The post-menopausal