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Transient Athetosis Induced by Tiagabine

Summary:  Movement disorders have been reported with use of different antiepileptic drugs (AEDs). We report a 32‐year‐old woman, affected by a symptomatic focal drug‐resistant epilepsy and a mild hemiparesis, with acute athetoid movements, transiently linked to increasing tiagabine (TGB) therapy. To our knowledge, no other cases of acute athetosis related to TGB have been reported to date. However, we cannot rule out the possibility that involuntary movements were induced by an interaction between TGB and concomitant AEDs, in particular phenobarbital (PB), possibly by increasing GABAergic transmission.