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Serum Theophylline Concentrations and Pulmonary Mechanical Functions Following Single and Steady-State Dosing with a Sustained-Release Theophylline Capsule

bronchodilator medications and xanthine containing foods such as coffee, tea, cola beverages, chocolate, etc., for a minimum of 24 hours prior to Study Visit Number One, and for the duration of the study. On Day-One, after resting for at least one hour in the laboratory, venous blood was withdrawn for measurement of serum theophylline concentration, and pulmonary mechanical functions were measured. Then, Elixophyllin Elixir, 250 mg, was given orally, and blood samples, as well as the pulmonary mechanical functions (using an Ohio No. 842 direct-reading spirometer) were obtained at 90 and 300 minutes after the oral administration of the drug.2 Each