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Structure and function of myelin protein genes.

Myelin is a unique cellular organelle produced in both the central (eNS) and peripheral (PNS) nervous systems. It plays an important role in saltatory conduction along the axon in both the eNS and PNS. eNS oligodendrocytes send out processes to recognize the axons nearby and wrap them to form compact lamellae. In the PNS, Schwann cells move around to form compact myelin lamellae. Myelination includes the process ofneuron-glia cell recognition, molecular assembly of myelin components, and compaction of membranes to form lamellar structures. The expression of several myelin proteins is highly specific to the nervous system, and, therefore, the genes coding these proteins provide good models by which to analyze gene expression in the nervous system. We focus here on the structure and function of genes encoding myelin basic protein (MBP), proteolipid protein (PLP), and myelin-associate d glycoprotein (MAG),