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Mini and customized low-cost bioreactors for optimized high-throughput generation of tissue organoids.

Organoids are three-dimensional (3D) tissue-like constructs that differentiate from stem cell-derived, self-assembled embryoid bodies to closely resemble the complex environment, architecture, and function of the native tissue. The cellular microenvironment produced by organoids vastly outclasses the capacity of a standard 2D cell culture plate to simulate the intricacies of living biological systems.