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The in vitro effects of calcium and potassium in resensitization of tracheal smooth muscles of the allergized guinea pig.

Tracheal smooth muscle obtained from allergized guinea pigs gives rise in vitro to two-phase cycles of responsiveness to antigen administration desensitization produced immediately after a conditioning antigen dose, followed by resensitization within 4 h. As in the case of resensitization to a drug, resensitization to an antigen is a Ca++- and K+-dependent phenomenon. A comprehensive receptor model of the chemical excitatory action of antigen in cells is consistent with a Ca++-dependent resensitization phenomenon in the allergized systems. On the other hand, the results bear weight against both a 'pharmacological mediator-depletion theory' and an 'antibody saturation-desaturation theory', which have been invoked to explain desensitization and resensitization to antigen in allergized systems.