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In-vitro hyperthermia studied by cellular impedance sensors

In this paper, we used an experimental platform based on cellular impedance sensors to study cellular changes after hyperthermia treatments. Impedance profiling showed high correlation with traditional MTT results, thus the impedance data represent cell viabilities very well. Then, status of cells under six typical hyperthermia treatments with different temperatures between 41-46 °C and different treating durations (0-30 min, 45 °C) were examined by the platform separately. The results showed increasing cell damage occurred when temperature or duration increased, and indicated the thresholds of temperature (~43 °C). Moreover, it is possible that a thermal isoeffect dose (TID) threshold exists in the two cell lines (equivalent time at 43 °C EM43=30~40 min). These results fit previous theories of hyperthermia, demonstrating that the cellular impedance sensor is a useful analytical tool for the in vitro research of thermal therapy.