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Analysis of copper and zinc levels in the mucosal tissue and serum of oral submucous fibrosis patients

Background and Objectives:Although the pathogenesis of oral submucous fibrosis (OSMF) has been studied, it remains unclear whether or not this illness might progress to malignancy. The pathogenesis of the illness may be better understood by measuring copper and zinc levels in tissue and serum from these people. Because of the widespread cultural and social usage of areca nuts in India, a research was conducted to investigate their concentrations in this population. Methods:Twenty people with OSMF and twenty people without it were studied in a case-control fashion. Copper and zinc concentrations were measured in the 40 patients' tissues and blood using colorimetry. Compared to the zinc concentration of 25.18 4.92 g/gm found in OSMF group tissues, copper concentration was 4.31 1.13 g/gm. Zinc levels were 0.92 0.18 g/ml and serum copper levels were 1.00 0.20 g/ml on average in the OSMF group. Interpretation and conclusion:OSMF group tissue zinc levels were substantially different from control group levels (p = 0.009), as were OSMF group tissue copper levels (p = 0.001). There was no statistically significant difference in serum copper (p = 0.35) or zinc (p = 0.08) between the experimental and control groups. 