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Tumor-associated tissue eosinophilia in the urinary bladder: is it a real relationship?

Local tissue eosinophilia in different carcinomas is a well-described phenomenon which could have prognostic significance. The etiology and pathogenesis of this tissue reaction are controversial and not understood. We found in sequential biopsies of transitional cell carcinomas of the urinary bladder that the most obvious relation was between eosinophilia and granulation tissue. This finding may indicate a nonspecific, nontumor-related tissue eosinophilia.