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Different fibronectin concentrations in plasma samples drawn from the affected and unaffected arms of a pagetic patient.

Plasma fibronectin concentrations in blood drawn from both arms of a pagetic patient affected only at the humerus, ulna and radius of the right arm were studied. Significantly higher levels were observed in the affected arm compared to the nonpagetic arm. Results suggest that in vivo synthesis of soluble fibronectin is associated with increased bone turnover and demonstrate the value of bilateral blood sample collection when localized bone disease is present.