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Glioma: from molecule to treatment

value in diagnosis, and also provide important prognostic information. In understanding the course of MS, the main observations are: I. Focal demyelination is normally associated with an initial phase of blood brain barrier breakdown and inflammation. 2. Axonal damage and loss occurs in lesions and normal appearing tissues and becomes increasingly marked with progressive disability. 3. Axonal loss is partly related to inflammation and partly independent. 4. Progressive abnormality occurs in the normal appearing white matter which precedes focal lesions and may be associated with progressive disability. 5. Brain plasticity occurs in response to MS pathology. There are important unresolved questions. One is the extent to which early inflammation and its suppression modulate the long-term prognosis for disability and axonal loss. Serial studies from clinical onset using multiple MR techniques are required. Other areas where new MR developments may assist are in monitoring remyelination, and the development of cell specific imaging.