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The Comparison of Homocysteine Levels with Stress Gated Myocardial Perfusion Defect Scores of the SPECT Study

Objective: In our country, the prevalence of Coronary Artery Disease (CAD) has been increasing and becoming one of the most important health problems. GATED SPECT myocardial perfusion scintigraphy is a non-invasive, simple and easy technique used in diagnosis and predicting prognosis of CAD. The aim of this study was to compare the level of Homocysteine (HCY) with stress defect scores which obtained from GATED Myocardial Perfusion SPECT study. Methods: Between November 2012 and March 2013, 166 patients referred to our department for MPS with a suspected CAD were included in our study. The mean age was 56 ± 11.6 and 70 were male. HCY level was measured by ELISA method from blood samples. Ischemia positivity was interpreted through MPS images. The numerical parameters of the left ventricle were obtained automatically by the software quantitative gated SPECT (QGS). Results: According to the scintigraphy results, 60 (57.1%) patients were normal and 45 (42.9%) were ischemia positive; the level of HCY was 16.36 ± 9.7 μmol/L in the normal group and 16.6 ± 8.5 μmol/L in the ischemic group (p = 0.895). Conclusion: We found no significant correlation between HCY levels and risk parameters obtained from GATED myocardial perfusion SPECT.