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Stimulation of ribonucleic acid polymerase activity in mouse kidney.

As part of an ongoing study to determine the mechanisms that differentiate between the agonistic and antagonistic effects of steroids, several natural and synthetic compounds that bind to the androgen receptor were evaluated for their effects on renal nuclear RNA polymerase I and II activities. The androgenic progestin 6α-methyl-progesterone (6MP) as well as the antiandrogens cyproterone acetate (6-chloro-17α-acetoxyl-l,2α-methylene-4,6-pregnadiene-3,20-dione) and flutamide (4′-nitro-3′-trifluoromethylisobutyrylanilide) and ineffective steroids 17α-hydroxy-6MP and progesterone were studied using normal and Tfm/Y mice, which lack effective androgen receptors. In normal mice, a single dose of 6MP stimulated a biphasic pattern of early (30 min) and late (16–24 h) increases in the activities of RNA polymerase I and II, which was similar to the responses induced by testosterone and medroxyprogesterone acetate (6α-methyl-17α-acetoxy-4-pregnene-3,20-dione). Cyproterone acetate stimulated an early increase in pol...