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Laminin in the interstitium indicates prognosis in patients with IgA nephropathy

Laminin is implicated in cell migration, remodelling of the extracellular matrix and basement membrane. Therefore, laminin deposition could be of concern in the progression of some renal diseases. In the present study, immunohistochemical and in situ hybridization studies were performed for laminin in IgA nephropathy (IgAN) specimens in order to reveal the importance of laminin deposition for their prognosis. Fifteen patients were used as the stable group who maintained stable renal function for more than 10 years after biopsy. Thirteen patients formed the progressive group who reached end‐stage renal failure within 10 years after biopsy. Immunohistochemically, laminin was specifically deposited in damaged glomeruli and strong immunoreactivity was particularly shown in the expanded interstitial area containing infiltrating mononuclear cells. Although the staining score in glomeruli was not significantly different between these two groups (P = 0.181), deposition in the expanded interstitium was extensive and significantly greater in the progressive group (P < 0.01). In situ hybridization revealed that most of the interstitial cells and some of the tubular cells expressed laminin messenger ribonucleic acid. In conclusion, the extent of interstitial laminin deposition was an important prediction of adverse renal outcome. This laminin could be produced by interstitial cells and/or tubular cells.