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Modulation of Pituitary Adenylate Cyclase‐Activating Polypeptide (PACAP) Expression in Explant‐Cultured Guinea Pig Cardiac Neurons

Abstract:  Pituitary adenylate cyclase‐activating polypeptide (PACAP) expression was quantified in explant‐cultured guinea pig cardiac ganglia neurons. In explant culture, both the percentage of PACAP‐immunoreactive neurons and pro‐PACAP transcript levels increased significantly. Treatment with neurturin or glial‐derived neurotrophic factor significantly suppressed the percentage of PACAP‐IR neurons, but not pro‐PACAP transcript levels.