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Early responses of testicular interstitial cells to stimulation by interstitial-cell-stimulating hormone.

The fine structure of testicular interstitial cells from mice submitted to different experimental conditions is described. Following treatment with methallibure (I.C.I. 33,828; 1-α-methylallylthiocarbamoyl-2-methylthiocarbamoylhydrazine), a selective inhibitor of hypophyseal gonadotropic activity, interstitial cells acquire a quiescent appearance characterized by: (1) accentuated segregation of agranular endoplasmic reticulum from other cytoplasmic organelles and inclusions, (2) increased depots of lipid droplets. A single injection of interstitial-cell-stimulating hormone (ICSH or LH) induces prominent changes in the ultrastructure and distribution of cell inclusions and organelles that are seemingly related to augmented secretory activity. The cell surface shows a striking development of cytoplasmic processes that interdigitate with similar processes from adjacent cells. Intercellular spaces form a system of interfacial channels providing a direct connection of the interstitial cell surface with blood vessels and the myoid layer of seminiferous tubules. Gonadotropic stimulation causes an increased number of free ribosomes and expansion of the Golgi complex and rough endoplasmic reticulum. There is a marked depletion of lipid droplets and formation of lipofuscin granules.