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Impaired maturation of cortical GABAA receptor expression in pediatric epilepsy

Purpose:  Expression of the protein subunits that make up the γ‐aminobutyric acid (GABA)A receptor pentamer is known to change during postnatal brain development in animal models. In the present study, analysis of cortical GABAA subunit expression was performed in control human tissue obtained from infancy through adolescence, and was compared to that from similarly aged children with intractable focal epilepsy.