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Histopathological Evaluation of Non-Obstructive Azoospermic Males Using Testicular aspirate (TESA) biopsy

Background: Male infertility considers a real diagnostic challenge because of several factors have been involved in its pathogenesis. Histopathology of the testicular biopsy consider the corner stone in the diagnosis. The aim of this study is to report the utility of using of Testicular aspirate biopsy (TESA) for the evaluation of the male infertility & compare the outcomes with different parameters. Materials & methods : we design prospective study for 205 infertile males with Non -Obstructive azoospermia who referred to the Teeba IVF & genetic center for the period from December 2016 to December 2018, they underwent bilateral TESA for histopathological evaluation & 45 patients out of 205 male had previous open testicular biopsy. The hormonal profile for all patient. were done. Results: among 205 patients underwent TESA procedure the commonest histopathological pattern was spermatocyte maturation arrest, present in 113 patients (55.1%) followed by round maturation arrest in 41 (20%). There was a good degree of agreement between the spermatogenesis scoring according to TESA and open surgical biopsy (P=< 0.001). The plasma levels for both LH & FSH were statistically showing significant differences in their levels according to the TESA spermatogenesis scoring. (P<0,001). Conclusion: the utility of TESA biopsy in the evaluation of testicular biopsy from Azoospermic males is significantly associated with the histopathological pattern of spermatogenesis & hormonal profile.