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L-asparaginase induced hypofibrinogenemia and cerebral venous thrombosis in a case of acute lymphoblastic leukemia

L-asparaginase, a chemotherapeutic agent, is commonly used in the treatment of acute lymphoblastic leukemia patients. L-asparaginase therapy is associated with low fibrinogen levels and thrombosis. Cerebral venous thrombosis is the dreaded form of thrombosis in such patients. Management in such situation is not standardized owing to its rarity in the literature. We present here management of such a case with a brief review of the literature.