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Inhibiting Effect of Aloe-emodin to Streptococcus pneumoniae Invasion of A549 Cell

Objective To study the effect of aloe-emdion on blocking the F-actin rearrangements in the Streptococcus pneumoniae invaded A549 cells. Metho d F-actin rearrangements was observed by fluorescent staining method. Results The invasion rates of S.pneumoniae to A549 cells pretreated with aloe-emodin and without treatment were (22±4)CFU/well and (138±21)CFU/well respectively(P0.0 1). Intact S.pneumoniae promoted F-actin rearrangements. Aloe-emodin was able to prevent S.pneumoniae from invasion into A549 cell. Conclusion Aloe-emodin can inhibited the typeⅡ pneumocytes filamentous actin rearrangements induced by St reptococcus pneumoniae.