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Calcium phosphate-based nanocomposite carriers for local antibiotic delivery against an osteomyelitis agent

ABSTRACT Bacterial infections particularly osteomyelitis have become one of the most prominent challenges for orthopaedic surgeries. The treatment of osteomyelitis requires the sequence of debridement, foreign body removal and antibiotic therapy. In this regard, to develop an appropriate drug delivery system a novel calcium phosphate nanocomposite cement was synthesised and loaded with cloxacillin drug against an osteomyelitis agent. Chemical and structural properties of the cement were analysed by X-ray diffraction, Fourier transform infrared spectroscopy and field emission scanning electron microscopy. Antibiotic release assay was conducted to obtain the rate and total time of release in different primary doses. The results showed that by increasing the amount of drug dose in the structure of the cement the release rate is reduced and subsequently sustain drug release with the effective concentration is obtained. Generally, effective bacterial growth inhibition and sustain release is indicative of the suitability of this nanocomposite cement for treating osteomyelitis.