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Identification of sur2 mutation affecting the lifespan of fission yeast.

Yeast is a suitable model system to analyze the mechanism of lifespan. In this study, to identify novel factors involved in chronological lifespan, we isolated a mutant with a long chronologically lifespan and found a missense mutation in the sur2+ gene, which encodes a homolog of S. cerevisiae sphingolipid C4-hydroxylase in fission yeast. Characterization of the mutant revealed that loss of sur2 function resulted in an extended chronological life span. The effect of caloric restriction, a well-known signal for extending lifespan, is thought to be dependent on the sur2+ gene.