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Late-onset coronary thrombosis and thrombocytosis following G-CSF treatment in a healthy donor: A Case Report

Granulocyte colony stimulating factor (G-CSF) has been widely used as a
mobilizing agent to rapidly increase peripheral blood stem and
progenitor cells. Limited data is available for G-CSF-associated
late-onset coronary thrombosis and thrombocytosis. We report a case of a
23-year-old Chinese Han patient who presented with acute myocardial
infarction and thrombocytosis after finishing bone marrow harvesting and
peripheral blood stem cell collection following G-CSF treatment several
days later. By using antiplatelet drugs and undergoing percutaneous
transluminal coronary angioplasty, the patient’s symptoms were relieved
and his platelet level decreased to normal. This is the first suspected
case report of late-onset coronary thrombosis and thrombocytosis related
to G-CSF. Caution should be taken for the delayed adverse reactions in
patients undergoing G-CSF mobilizing.