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Validating cell‐free DNA from supernatant for molecular diagnostics on cytology specimens

Cytology specimens are often used for biomarker testing in the setting of neoplasia. On occasion, formalin‐fixed paraffin‐embedded (FFPE) cell blocks unfortunately may not yield sufficient material for testing. Recent studies have suggested that residual supernatant fluid from cell block preparation is a valuable source of DNA: both cellular and cell‐free DNA (cfDNA). In the present study, the use of cfDNA from supernatant is compared against DNA from FFPE materials.