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Protective value of diphenylhydantoin and vitamin A against stress ulcer.

The protective effect of vitamin A and diphenylhydantoin on restraint ulcers has been studied in 105 rats. The Sprague-Dawley female rats were divided into four groups. All were fasted for 24 hours, then restrained and fasted for another 24 hours. Control rats (receiving 1 ml of 0.9% saline solution) were compared with groups receiving either vitamin A, diphenylhydantoin, or both. Diphenylhydantoin significantly (P less than 0.001) protected the rats against ulcers. Vitamin A showed no protective effect and did not potentiate the effect of diphenylhydantoin.