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A MULTIVARIATE TEST FOR SIMILARITY OF TWO DISSOLUTION PROFILES

ABSTRACT A multivariate test of size α for assessing the similarity of two dissolution profiles is proposed. The inferential procedure is developed by using the approach for the common mean problem in a multivariate setup due to Halperin (1961). The performance of the proposed method is compared with Intersection Union Test as well as f 2 criterion recommended by the FDA through a simulation study. All the methods are illustrated with real examples.