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[The effect of thyroid- and parathyroidectomy on stress-induced changes in the primary humoral immune response of white rats].

The influence of the immobilization stress (24 h) was studied on male white rats of Wistar strain, examining the primary humoral immune response on the background of thyroid- and parathyroidectomy. It was established that parathyroidectomy induced immunodepression, but the effect of immobilization stress, used just next to immunization with sheep erythrocytes intensified immunodepression. Furthermore application of stress after immunization with sheep erythrocytes (during the effective phase of the immune response) induced immunostimulation. These differences in stress-induced immunological changes could be explained by the peculiarities of neuroendocrine and immunological status during the variants of stress action.