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The assessment of gastric acidity and antacid effect in pregnant women by a non‐invasive radiotelemetry technique

Summary. Non‐invasive radiotelemetry techniques were used for the in‐vivo assessment of gastric acidity and the effect of antacids in non‐pregnant women and women in the third trimester of pregnancy. A particulate (magnesium trisilicate mixture) and a non‐particulate (sodium citrate) antacid were studied. There was no significant difference in basal gastric acidity and gut transit time between the pregnant and non‐pregnant subjects. The median and range of values for the efficacy (defined as the integrated area under the pH/time curves) of sodium citrate was 138.3 pH.min (29.8–520.7) in the non‐pregnant and 103.0 pH.min (54.3–375.6) in the pregnant subjects. The median and range of values for the duration of action of sodium citrate were 38.6 (18.1–147.4) min in the non‐pregnant and 30.5 (20.0–119.1) min in the pregnant women. Magnesium trisilicate mixture resulted in a greater intragastric pH change and had a greater efficacy than sodium citrate, but the duration of action of the two antacids was similar.