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The activity of β‐adrenoceptor blocking agents in protecting mice from the cardiotoxic effects of ouabain

A method is described for the assessment of the protective activity of drugs against the lethal effect of intravenously infused ouabain in mice. Electrocardiographic studies confirmed that protection is exerted against a cardiotoxic action of the glycoside. Activities are quoted for some β‐adrenoceptor blocking agents. Both (‐)‐ and (+)‐enantiomers of propranolol were active but only the (‐)‐enantiomer of sotalol and INPEA‐drugs devoid of membrane‐stabilizing properties.