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Dynamic integration of manual and automated biological process skills into MES

The manual cultivation of biological cells is very time- and cost-intensive. The automation of these processes promises significant cost savings as well as the required transparency and quality of the results. Biological cell cultivation protocols are constantly being researched and modified, which enormously increases the flexibility requirements for the plant technology. An important aspect is the early consideration of different laboratory equipment and the possibility of step-by-step partial automation of biological processes. In the course of process development and automation, it helps that manually executed process parts can be transparently integrated into the higher-level process control before they are automated using suitable laboratory equipment. Furthermore, device failures can be replaced by manual process execution. This paper presents a method for mapping biological skills using OPC UA models and integrating them into automated plants.