{'fraction_non_alphanumeric': 0.029473684210526315, 'fraction_numerical': 0.0, 'mean_word_length': 6.104477611940299, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Drug Class Review: Thiazolidinediones

II. Pharmacology Pioglitazone and rosiglitazone are thiazolidinediones (TZDs) that act primarily by decreasing insulin resistance. Their mechanism of action for improving insulin sensitivity is not yet fully understood. They are selective agonists for peroxisome proliferator-activated receptor-gamma (PPARγ). Activation of PPARγ receptors results in increased glucose transport into cells in adipose tissue, skeletal muscle, and liver.