{'fraction_non_alphanumeric': 0.030332681017612523, 'fraction_numerical': 0.046966731898238745, 'mean_word_length': 5.089285714285714, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Agmatine Inhibits Naloxone‐Induced Contractions in Morphine‐Dependent Guinea Pig Ileum

Abstract: This study investigates the effects of agmatine on naloxone‐precipitated withdrawal syndrome in morphine‐dependent guinea pig ileum. Male guinea pigs that were starved for 24 hours were decapitated after cervical dislocation, and terminal portions of the ilea were removed. Segments were fixed at a resting tension of 1 g in an organ bath containing 1 3 1026 M morphine in Tyrode solution at 378C, which was bubbled with 95% O2 and 5% CO2. Tissues were incubated in morphine containing Tyrode solution for 4 hours before agmatine was added. Naloxone and agmatine had no effect on naive ilea. Naloxone (1 3 1026 M) contracted morphine‐dependent ilea. Agmatine significantly inhibited the contractile response to naloxone in a dose‐dependent manner (1 3 1027 M, 44%; 1 3 1026 M, 80%; 1 3 1025 M, 95%). This effect of agmatine was partly abolished by pretreatment with yohimbine and was almost completely abolished by idazoxan.