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[Effect of padan on active sodium transport in the epithelium of isolated frog skin].

The effects of " Padan " (hydrochloride of 1.3-di/ carbomylothio /-2-N-dimethylamino/propane/ upon transport capabilities of plasmatic membrane have been checked. The experiment was performed on isolated skin of Rana temporaria frogs. Assessment of transporting activity of membrane in relation to sodium ion involved a method developed by Ussing with so called "short-circuit" technique. The effects of the pesticide on the external and internal surface of the frog's skin have been examined, final concentrations of the compound being 3.4 X 10(-6) M to 3.4 X 10(-3) M. The results indicate that " Padan ", whether administered to the external or internal surface of the membrane, decreases the value of membrane potential and short-circuit current, which is indicative of membrane transport inhibition. The effect varies with pesticide concentration in the medium, though it is statistically significant only in concentration 3.4 X 10(-3) M. On the other hand, membrane resistance usually gets increased as the compound concentration in the medium increases. The results indicate that cellular membrane should be considered while explaining the mechanism of toxic effects of " Padan " upon organism.