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Antioxidant and Antiproliferative Activity of Noni Fruit (Morinda citrifolia) Extracts Against Human Breast Cancer Cell Line (MCF-7)

Noni juice, obtained from the fruit of the noni tree (Morinda citrifolia L.), is a popular commodity in the market, particularly in the South Pacific. It is widely used by consumers for the prevention of several lifestyle diseases. Although there is increasing interest in the potential therapeutic use of noni plants, there are no comparative studies on the various commercialized noni fruit juices available to decipher their phytochemical composition and properties against carcinomas. The present study, therefore, aimed to investigate the juice’s anecdotal use as complementary alternative medicine to manage cancer. In this study, we evaluated the cytotoxicity and antioxidant activity of M. citrifolia fruit extracts. DPPH (2,2-Diphenyl-1-picrylhydrazyl) tests were used to assess the antioxidant of the extracts. The cytotoxicity of the MCF-7 breast cancer extracts was performed using the MTT procedure. Antioxidant and anticancer studies showed the potential activity of M. citrifolia fruit extracts. Further work involving more extensive in vitro and in vivo studies are needed to elucidate its anticarcinogenic activities.