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Inhibition of DNA synthesis in rat hepatoma and human lymphoma cell lines, by partially purified factors from mouse embryos.

Cancer cells express particular genes, part of which are normally active during the embryonic development. On the other hand, young embryos are able to differentiate and regulate the division rate of teratocarcinoma or leukemia cells, likely by producing differentiation factors. A partial purification of these factors, extracted from mouse embryo cell nuclei, was achieved by high performance liquid chromatography on anion exchange column. High ionic strength eluting fractions, constituted with DNA and tightly bound proteins, have a high inhibitory effect on DNA synthesis, in rat hepatoma and human lymphoma cell lines. The possibility of treatment of cancer cells in this way is discussed.