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Association of Procalcitonin Values with Mortality of Elderly Sepsis Patients

Background: Elderly is an age group that is prone to sepsis and is sometimes difficult to enforce because signs of inflammation rarely appear. Procalcitonin is a specific marker for bacterial infection in the elderly and can be a sign of the severity of sepsis and can be used as a predictor of septic death in the elderly. The purpose of this study was to determine the relationship between procalcitonin levels and mortality in elderly septic patients.
Methods: This study was an analytic observational study with a retrospective cohort design. Data were obtained from the patient's medical records. To analyze the sensitivity and specificity of procalcitonin values ​​in sepsis patients, statistical analysis of receiver-operating characteristics (ROC) curves was used with significant results if the ROC curve value was more than 50%. To determine the procalcitonin value with outcome, Chi-square test was performed. The data was processed with SPSS version 22.0. The test results are said to be meaningful if the p value <0.05.
Results: The subjects of this study amounted to 52 people who met the inclusion and exclusion criteria. The median value of the age of the subjects was 66 (60-87) years with the most male subjects 51.92%. The diagnosis of severe sepsis was 48.08% followed by 29.62% sepsis and 25% septic shock. Subjects died as many as 27 subjects (51.92%). Hemoglobin level 11.3 g/dl; leukocytes 15.26.103/ml; platelets 150.103/ml and the value of procalcitonin 12.42 mcg/dl. The procalcitonin ROC curve showed that procalcitonin had a good predictor value (AUC 79.7%; p value 0.001), the procalcitonin value was 12.67 mcg/dl. Procalcitonin levels >12.67 mcg/dl died in 12 (75%) patients while elderly patients with procalcitonin levels <12.67 mcg/dl died in 6 (25%) patients. The chi-square test got a p value of 0.001 (RR 3 CI 95% 1.453-6.196).
Conclusion: Procalcitonin is associated with mortality in elderly septic patients

Keywords: Procalcitonin, Sepsis, elderly.