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Reduced Ischemia in the Medial Vestibular Nucleus after Premedication of Cilostazol and Ginkgo Biloba Extract in Global Hypoperfusion Rat Model

Introduction Approximately 20% of cerebral ischemia is known to develop in the territory of the vertebrobasilar artery and the most common symptoms of vertebrobasilar ischemia (VBI) are dizziness and vertigo [1]. Isolated vertigo without other neurologic symptoms has generally been ascribed to peripheral vestibular diseases [1]. Of the patients with vertigo due to VBI, however, 62% had at least one isolated episode of vertigo, and 19% developed vertigo as the initial symptom [2]. A recent study also found that the patients hospitalized with isolated vertigo have a threefold higher risk for strokes than the general population during the 4year follow-up [3]. Objective: The aim of this study was to determine preventive effects of premedication with combination of cilostazol and ginkgo biloba extract during vertebrobasilar ischemia (VBI) induced by global hypoperfusion in rats. Citation: Lee JO, Kim HJ, Kim JS (2015) Reduced Ischemia in the Vestibular Nucleus after Premedication of Cilostazol and Ginkgo Biloba Extract in Global Hypoperfusion Rat Model. J Neurol Neurol Disord 2(2): 203. doi: 10.15744/2454-4981.2.203