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Somatostatin blockade improves the proliferative response but not intestinal morphological growth after small bowel resection in rats.

OBJECTIVE
To find out whether or not blockade of somatostatin improves intestinal adaptation after small bowel resection.


DESIGN
Laboratory experiment.


SETTING
Teaching hospital, Spain.


SUBJECTS
Eighty adult Wistar rats.


INTERVENTIONS
Animals underwent intestinal resection or sham operation (n = 40 each) and were treated with a somatostatin antagonist either intermittently or continuously in three different doses (n = 8 each).


MAIN OUTCOME MEASURES
Bowel mucosal thickness, proliferation and concentrations of cAMP, somatostatin, insulin-like growth factor 1.


RESULTS
Intestinal resection induced a proliferative and morphometric increase of the mucosa; however, the antagonist increased proliferation only in those animals given the highest dose. Intermittent doses induced a proliferative effect that was stronger than that in the three continuous groups. There was no relationship between trophic stimulus and insulin-like growth factor 1 or cAMP, but somatostatin concentrations increased after the intermittent course.


CONCLUSIONS
Somatostatin receptor blockade with an antagonist does not cause in normal rats an intestinal morphological adaptation process or increase it after resection; however, it did promote a proliferative stimulus in the crypts.