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Hunanamycin A, an antibiotic from a marine-derived Bacillus hunanensis.

Hunanamycin A, the first natural product with a pyrido[1,2,3-de]quinoxaline-2,3-dione core, was isolated from a marine-derived Bacillus hunanensis. Hunanamycin A is related to a degradation product of riboflavin but has undergone an N-prenylation and subsequent cyclization. The structure, including stereochemistry, was determined by NMR and MS methods. Hunanamycin A exhibits a minimum inhibitory concentration (MIC) of 12.4 μM against the bacterial pathogen Salmonella enterica.