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SYNOVIAL FLUID DRUG LEVELS: THE RECOVERY OF PENICILLINS AND PREDNISOLONE AND THEIR ESTIMATION BY HPLC

Many studies have defined conditions for the estimation of drugs in blood, its fractions and urine but little systematic data is available for estimating drugs in synovial fluid. Although synovial fluid contains many of the electrolytes and proteins found in plasma it also contains a few unique proteins and a very high content of hyaluronate. The polyanionic structure of hyaluronate confers a high viscosity on synovial fluid although this viscosity may be reduced in arthritic conditions. The high viscosity compared to plasma and the small, variable amounts of synovial fluid available makes the extraction of drugs more difficult.