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DEVELOPMENT OF RENAL DOSING GUIDELINES FOR NONSTEROIDAL ANTI-INFLAMMATORY DRUGS AND ANTIBIOTICS - A PROSPECTIVE STUDY

Objectives: The objectives of this study were to determine the impact of renal dosing guidelines on prescribing pattern for nonsteroidal anti-inflammatory drugs and antibiotic in patients with chronic kidney disease (CKD).Methods: This was a prospective interventional study. The study was divided into two phases, pre-intervention and post-intervention phases. Data regarding the kidney function and the pattern of drug dosing will record in the pre-intervention phase. Pocket guides were prepared for the drug dosing in renal impairment and were distributed to clinicians and the pharmacist as a part of intervention. In the post-intervention phase, the dosing pattern of renal eliminated drugs was observed for any improvement. The patterns of dosing of renal eliminated drugs were compared in both the phases.Results: In pre-interventional phase, a total of 43 cases were reviewed, 20 of them were non-hemodialysis (non-HD) (9 female and 11 male) cases with a mean±standard deviation (SD) age of 56.05+8.22 (56) and 23 were undergoing HD (11 female and 12 male) cases with a mean±SD age of 56.72+6.85 (56). In the post-intervention phase, a total of 41 cases were reviewed, 22 of them were non-HD (12 female and 10 male) cases with a mean±SD age of 55.85+6.87 (57) and 19 were undergoing HD (10 female and 9 male) cases with a mean±SD age of 55.77+8.39 (56.6).Conclusion: Health-care professionals have an important responsibility in monitoring the dose for renal impairment patients. Development of renal dosing guidelines for patients hospitalized with CKD can improve the pattern of prescribing in renal failure population. 