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[Malignant melanoma of the nose and paranasal sinus (author's transl)].

Six patients with malignant melanoma in nasal cavity and paranasal sinus were treated in our clinic during 27 years from 1950 to 1976. Age ranged from 49 to 79 years. Sex distribution was 3 males and 3 females. The malignant melanoma was observed in nasal septum in three cases. In remaining three cases it developed in middle turbinate, in middle meatus, and in middle turbinate as well as maxillary sinus, respectively. They were treated with a combination of operation, irradiation, and administration of anticancerous drugs. In two cases, who were treated recently, immunotherapies (BCG etc.) were also administered.One case, whose tumor was classified as the spindle cell type histologically, survived more than five years without recurrence. Four of the five cases with the large epitheloid cell type died within one and a half year. Remaining one case, treated with BCG and b'Co irradiation has been surviving for about ten months.Electron micrograph of one case revealed large nuclei and deep invaginations of the nuclear membranes, but no desmosome in cell membranes. The nuclei contained very large nucleoli and exhibit some vacuolelike structures.Autopsy was performed in two cases. One case showed predominant, hone metastasis (thecranial base and the spinal column etc.) along with lung metastasis. In the second case, predominant visceral metastasis (lungs, liver, and pancreas etc.) was observed as well as pleura, bone (the spinal colum etc.) and forehead skin metastasis.We collected 67 cases of malignant melanoma in nose and paranasal sinus from Japanese literature (which were published from 1965 to 1975). In Japan, malignant melanomas originated in nasal cavity and paranasal sinus are thought not so rare disease as mentioned before.