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Knights in Shining Armor.

With recent advances in sequencing technology, our understanding of the role of the gut microbiota in human health and disease has expanded significantly. In cardiovascular disease, the total number of studies is still small, with the majority reporting associations between the composition of the gut microbiota and markers of cardiovascular disease. Different bacteria synthesize and secrete a variety of metabolites that, through transport in the circulation, could act on distant host tissues. For example, higher concentrations of circulating lipopolysaccharides, which are components of the outer cell wall membrane of gram-negative bacteria, have been linked to atherosclerosis likely through increasing local inflammation.