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Cytochrome P-450-catalysed Activity in the Rat Visceral Yolk Sac

A number of toxic metals are known to inhibit cell division during the DNA synthesis (S) phase of the cell cycle, but the human metallocarcinogen beryllium (Be), in contrast, produces a selective cell cycle block prior to DNA replication at the G1-pre-S phase,! Little is known of the molecular nature of this lesion, but other studies suggest that Be may interfere with the regulatory mechanisms controlling transcription.2 We surmised therefore that Be may exert some effect on the transcription of those nuclear proto-oncogenes thought to be associated with cell