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The motility of the pancreatic duct of the cat; an in-vitro study.

Segments of the pancreatic duct of cats were suspended in Krebs solution and connected to a force-displacement transducer. Spontaneous, rhythmic contractions were recorded from all parts of the duct. The contractions seem to be exerted by longitudinally orientated muscle cells and are probably myogenic. Acetylcholine, bradykinin and histamine increased the tension. Noradrenaline caused a slight increase in tone while isoprenaline relaxed the duct. The spontaneous activity was annulled when bile was present in the bath.