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Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells

Oestrogen receptor alpha (ERα) binds to different ligand which can function as complete/partial oestrogen‐agonist or antagonist. This depends on the chemical structure of the ligands which modulates the transcriptional activity of the oestrogen‐responsive genes by altering the conformation of the liganded‐ERα complex. This study determined the molecular mechanism of oestrogen‐agonistic/antagonistic action of structurally similar ligands, bisphenol (BP) and bisphenol A (BPA) on cell proliferation and apoptosis of ERα + ve breast cancer cells.