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The risk for cross‐reactions after a cutaneous delayed‐type hypersensitivity reaction to heparin preparations is independent of their molecular weight: a systematic review

Background. Heparins are a widely used class of drugs known to cause delayed‐type hypersensitivity (DTH) reactions. Recent publications indicate that the incidence of these may be higher than previously thought. To date, patient‐related but no drug‐related risk factors for the development of DTH reactions to heparins have been identified, although molecular weight is discussed as a potentially relevant parameter.