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A cross-sectional study to observe association of serum bilirubin levels with various subtypes of First Episode Psychosis.”

Introduction: Number of studies suggest correlation between hyperbilirubinemia, schizophrenia and first episode psychosis (FEP); however, few studies on similar lines have been done in Indian population. Aim: To observe the relationship between hyperbilirubinemia with subtypes of FEP, duration of illness, and severity of illness. Methodology: A cross-sectional study was done at a tertiary care centre amongst antipsychotic-naïve FEP patients. Substance-induced psychosis, organic psychosis and those with acute liver injury were excluded. CBC, LFT, RFT, Electrolytes, CRP, USG Abdomen, HIV, HBsAg and severity rating scale were done within 24 hours of admission. Result: Total 39 patients were included. There was statistically significantly higher total bilirubin and conjugated bilirubin levels in patients with Acute and Transient Psychotic Disorder (ATPD) as compared to schizophrenia and other types of FEP. Unconjugated bilirubin levels were also elevated in ATPD compared to other subtypes of FEP; however, not significantly. There was a significant correlation between serum bilirubin levels and severity of ATPD on Brief Psychiatric Rating Scale. There was no correlation between serum bilirubin and duration of illness in ATPD. Conclusion: Serum bilirubin elevation was found associated only with ATPD and not with other types of FEP.