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Basal Level of p70S6k Phosphorylation Is Higher In Aged Rats And Inversely Related To Muscle Atrophy

It has been shown that older adults have an attenuated hypertrophic response to resistance exercise when compared to young adults. The reason for this attenuation is currently unknown. However, some evidence suggests it could be at the level of mechanotransduction. Remedying this decreased response to resistance exercise could halt and potentially provide an avenue to reverse the age related loss of muscle mass and strength, also known as sarcopenia. p70 ribosomal protein S6 kinase (p70S6k) has been shown to play a role in protein synthesis regulation and muscle growth and phosphorylation of this protein is one of the early responses to mechanical stimulation