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A comparison of clinical characteristics, the in-hospital course, and 12-month prognosis in women and men with chronic coronary syndromes.

BACKGROUND
The prognosis of men and women with chronic coronary syndromes (CCS) remains ambiguous.


AIM
Comparison of clinical characteristics and the 12-month prognosis in women and men with CCS included in the prospective single-center registry.


METHODS
The study was based on the PRESAGE registry including 11 021 patients hospitalized between 2006 - 2016 with CCS and subjected to coronary angiography. The composite endpoint included death from any cause, non-fatal myocardial infarction, acute coronary syndrome with revascularization, unstable coronary artery disease, or stroke.


RESULTS
Women were older than men (mean 66.6 [SD 9.0] vs. 63.5 [9.6] years, P < 0.0001), arterial hypertension (85.8 vs. 79.0%, P < 0.0001) and type 2 diabetes mellitus (38.2 vs. 33.7%, P < 0.0001) were more frequently diagnosed in women. Multivessel disease or left main disease were more frequent in men. Percutaneous coronary intervention and coronary artery bypass grafting were performed more often in men than in women (47.1 vs. 36.0%, P < 0.0001; 10.6 vs. 6.1%, P < 0.0001). In 12-month follow-up, composite endpoint was more frequent in men (7.4 vs. 10.2%, P < 0.0001), including death (3.3 vs. 4.5%, P = 0.0016). In multivariable analysis, sex was not an independent predictor of composite endpoint (HR 1.08, 95% CI 0.89-1.31, P = 0.45) Conclusions: Women and men with CCS differ in the incidence of risk factors and revascularization treatments. Men were found to have a higher frequency of 12-month death and composite endpoint follow-up. However, sex is not independent predictor of 12-month outcomes.