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RISTOCETIN AND PLATELET AGGREGATION

We read with interest the case report by Selleri et a1 entitled ‘Cyclosporine A in adult-onset cyclic neutropenia’ (British Journal of Haernatotogy, 68, 137-141, 1988). The authors describe a patient with cyclic neutropenia and an excess of large granular lymphocytes (LGL) who was successfully treated with Cyclosporine A after failing to respond to steroid therapy. In 1986 we reported a patient with severe chronic neutropenia with humoral and cell-mediated inhibition of granulopoiesis (Baker et al. 1986). The patient’s IgG and Tlymphocytes inhibited the growth of her granulocyte-macrophage colony forming units (CFU-GM) in marrow cultures. This patient was successfully treated with Cyclosporine A after failing to respond to prednisone alone or in combination with cyclophosphamide or vinblastine. A detailed report of this work has recently been published (Baker et al, 1988).