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Pairing of VH gene families with the λ light chain: Evidence for a non‐stochastic association

The frequencies at which four VH gene families pair with the λ1 light (L) chain were determined by sequential hybridization of VH‐ and λ1‐specific DNA probes to mitogen‐induced colonies of B cells. Analysis of pair frequencies indicates that the repertoire of λ L chain antibodies is generated by the stochastic pairing of smaller 3′‐to‐mid‐locusVH gene families (X‐24, S107, Q52). However, the large 5′ VH J558 family appeared to associate with the λ1L chain non‐stochastically; the frequency of VhJ558/λ1+ colonies among all λ1+ colonies was significantly lower than the frequency of J558 expression among all (Cμ+) B cell colonies. This difference suggests that selection, either intrinsic at the level of rearrangement or heavy and L chain pairing, or extrinsic following surface immunoglobulin expression, may operate to shape the λ antibody repertoire prior to the introduction of exogenous antigen.