{'fraction_non_alphanumeric': 0.024725274725274724, 'fraction_numerical': 0.016483516483516484, 'mean_word_length': 5.334782608695652, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Diminished hepatic L-triiodothyronine nuclear receptor concentration in rats bearing the Walker 256 carcinoma is not due to a generalized decrease in nonhistone protein synthesis.

To determine whether the decrease in hepatic T3 nuclear receptors in rats bearing the Walker 256 carcinoma (T rats) is a consequence of nonthyroidal disease or related to a generalized decrease in hepatic protein synthesis, we measured hepatic T3 nuclear receptors and [3H]leucine incorporation into protein in control and T rats. Mean protein contents of liver homogenate, purified nuclei, 0.4 M NaCl extracts of nuclei, and nonhistone protein fractions were similar in control and T rats. In pooled data from three experiments, [3H]leucine incorporation into protein in these liver fractions was significantly increased (55-73%) in T rats. Since the precursor nonradioactive leucine pool, measured by a novel HPLC method, was similar in control and T rats, the increased incorporation of [3H]leucine in all liver fractions suggests an increase in protein synthesis in T rats. Additional measurements in the same rats (two experiments) indicated that hepatic nuclear receptors were decreased to 50% of the control value in T rats (P less than 0.001). Our findings suggest that in the Walker tumor model of nonthyroidal disease, decreased hepatic nuclear T3 receptors appears relatively specific and is not associated with a generalized decrease in hepatic protein synthesis.