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Polymorphonuclear leucocyte chemotaxis in Boyden chambers. Effect of low concentrations of vinblastine.

It has been reported by previous authors that vinblastine in high and presumably non-specific concentrations (10-5-10-4 M) inhibits polymorphonuclear (PMN) chemotaxis in vitro. In the present study, vinblastine in subantimitotic concentration (10-8M) induced maximal inhibition of PMN chemotaxis in a modified Boyden chamber. It is suggested that the vinblastine inhibition of PMN chemotaxis is due to an interference with the spatial reorganization of centriole-associated microtubules during PMN direction-finding or PMN directional movement. The effect of subantimitotic concentrations of vinblastine and other antitubulins on PMN chemotaxis may have important applications in the treatment of diseases in which the tissue damage is mediated by the polymorphonuclear leucocytes.