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Ultrasound and Near Infrared Light Dual-triggered Upconversion Zeolite-based Nanocomposite for Hyperthermia Enhanced Multi-modal Melanoma Therapy via a Precise Apoptotic Mechanism.

High reactive oxygen species (ROS) generation efficiency as well as induction of targeted cells apoptosis are recognized as key objective to achieve highly efficient strategy for cancer therapy with minimum side effects of inflammatory reaction. However, it is still of challenge to realize higher therapeutic efficiency with a cell apoptosis model. Herein, we present strong upconversion luminescent biosafe cores derived from Linde Type A (LTA) zeolites and modification with targeted/therapeutic drugs for multi-modal therapy, in which sonodynamic therapy (SDT) combined with photodynamic therapy (PDT) increases therapeutic efficiency especially in deep sites of tumor via producing cytoplasmic ROS and mitochondrial superoxide, photothermal therapy (PTT) enhances PDT effects via higher fluorescence resonance energy transfer (FRET) efficacy attributed to an increased temperature. Furthermore, the transcriptomic analysis reveals that cellular internalization of the nanosystem can lead to tumor ablation via cell apoptosis. We expect the multi-modal therapy based on LTA zeolites drug-nanocarriers could be applied in the cancer therapeutics in the near future.