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Serum Ferritin Correlation Study in Idiopathic Parkinson ' s Disease Severity

Background: Iron and the extrapyramidal system may be strongly related. The diversity of response to this element may cast light on the possible mechanisms of idiopathic Parkinson's disease and the complex extrapyramidal system dynamics. Objectives: To evaluate the possible correlation of serum ferritin, and the severity of Parkinson's disease. Methods: Twenty five male idiopathic Parkinson patients were included. Full exclusion of secondary etiology was achieved. Clinical assessment was done using the Hoehn Yahr scale. Serum ferritin level was assessed and repeated one month later. Results: The serum ferritin level varied in Parkinson according to severity and duration of disease; it was high in 72% (328 ng/ml mean); normal in 20% (112 ng/ml mean) and low in 8% (23 ng/ml mean). Three Parkinson patients gave history of RLS before, and symptoms disappeared one year prior to their Parkinson features. Conclusion: Serum ferritin may correlate with the severity of idiopathic Parkinson disease. The diverse response of the extrapyamidal system to this element with the few studies performed requires more active and further investigations. (Egypt J. Neurol. Psychiat. Neurosurg. 2009, 46(2): 463-466)