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Book Reviews : Manual of Endocrinology and Metabolism

are appreciated because this often is neglected in larger textbooks of endocrinology. There is, however, a great deal of repetition because of this classification. The sections on the newer topics of endocrinology are fascinating and well covered but the authors omit or dilute their coverage of several topics such as conventional endocrine therapy of malignant disease and ectopic hormonal syndromes. A more detailed discussion of topics related to diabetes mellitus also is lacking, particularly brittle diabetes, diabetic neuropathies, second generation hypoglycemic drugs, and diabetes and pregnancy. The chapters on metabolic bone disease, in particular the one that deals with osteoporosis, fail to mention newer and controversial therapies such as calcitonin, diphosphonates, and vitamin D, as well as diagnostic radiological procedures such as absorptive densitometry. The discussions of metabolic bone disease, however, in particular those covering osteomalacia and steroid induced osteoporosis, are clear, concise, and well covered. The section on thyroid disease is very good but it lacks a detailed discussion of the immunology of thyroid disease. I also question the high incidence the authors state for carcinoma in thyroid nodules. The treatment of thyroid emergencies, particularly myxedema coma, is not covered in enough detail. The chapter covering thyroid tumors in children is an example of coverage of a topic that has more relevance to an adult population, as well as