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Peripheral metabolism of thyroxine and triiodothyronine in endemic goitre.

The peripheral metabolism of triiodothyronine (T3) and thyroxine (T4) were measured simultaneously in subjects with non-toxic goitre in Greece. Comparison to the results obtained in a control group demonstrated that goitrous subjects showed a normal peripheral T4 metabolism, while their T3 metabolism was enhanced, principally because of an increase of T3 space. It is suggested that the main compensatory mechanism for decreased iodine reserves in endemic goitre is an increase in T3 production and utilization.