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The Effect of Denuded Epithelium on Responsiveness of Stress-Induced Guinea-Pig Isolated Trachea To Vip (Vasoactive Intestinal Peptide) and Salbutamol

S U M M A R Y Both neural and neuropeptide control mechanisms of airway might be affected by stress, and the responses of airway to stress might also be af­ fected by epithelium. We, therefore, have investigated the effect of airway epithelium on responsiveness of stress-induced guinea-pig isolated trachea to VIP (Vasoactive Intestinal Peptide) and salbutamol. In addition, we histologically have examined the mast cells of the trachea. Contractile responses evoked by Acetylecholine (ACh) and histamine were more potent and rapid in stress-induced tracheal prepara­ tions with an intact epithelium than epithelium denuded. The most relaxing effect of VIP also occured in stress induced intact preparations precontracted by histamine. Although the relaxing responses of VIP absolutely depend on the presence of epithelium, salbutamol relatively depend. His­ tological results showed that degranulation and the number of mast cells may contribute to the etiology of stress-induced bronchial hyperreactivity or airway infections.