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The SCID-hu Mouse Model as a Tool in Dermatopharmacology Research: New Options and a Review of the Literature

Xenogeneic transplantation of human skin onto severe combined immunodeficiency (SCID) mice lacking functional B and T cells enables the investigation of the human skin organ in vivo by means of an animal carrier. Research on these grafts has yielded a variety of new insights into skin biology and disease. A promising approach is the applicability of this human cutaneous xenograft model for the purpose of drug screening and testing of new therapies. This article reviews the use of the SCID mouse model in terms of dermatotherapy studies and outlines the potential options of this animal model in dermatopharmacology.