{'fraction_non_alphanumeric': 0.008538899430740038, 'fraction_numerical': 0.0, 'mean_word_length': 5.242603550295858, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
THE INFLUENCE OF AGE ON THE ACTIVITY OF CATECHOLAMINES AND RELATED THERAPEUTIC AGENTS

A review has been made of the literature on the changes with age in the sensitivity of various organs and tissues to catecholamines. The objective of this review was to examine these changes and to interpret them in the light of related compounds that are employed commonly in the treatment of the elderly. The available evidence strongly indicates that there is an increase with age in the sensitivity to exogenously administered amines. In terms of the therapeutic application of related drugs in the elderly, this finding indicates that caution should be used when administering such agents, particularly if they have significant secondary effects which are related to the stimulation of adrenergic receptors. Additional information indicates that perhaps there is a delay in the excretion and in the distribution of catecholamines. Thus, higher blood levels might be anticipated when sympathomimetic amines are employed in the treatment of various disease states.