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A PARTICLE METHOD COMPUTER SIMULATION OF BLOOD FLOW

Summary A particle method computer simulation of blood flow is proposed to directly evaluate mechanical interactions between red blood cells (RBCs) and plasma. A moving particle semi-implicit method was used for flow analysis of blood plasma. An elastic membrane model was used for RBC deformation. Two-dimensional simulation of blood flow revealed that an RBC moved into downstream direction due to pressure drop of plasma flow and deformed itself in a parachute shape, corresponding to experimental observations. INTRODUCTION The blood flow at microscopic level plays an important role in pathological events in the vascular system such as thrombosis and hemolysis. Recent studies show that the particle method is useful in evaluating the mechanical behavior of blood cells under blood flow [1]. Since this method needs only computing nodes and is free from meshes, it is advantageous in directly tracking the blood cell motion by a particle in the Lagrangian coordinates, and in tracking the interface between solid blood cell and liquid blood flow. In this study, a computer simulation method using particle method for blood flow is proposed to directly evaluate mechanical interactions of red blood cells (RBCs) and plasma.