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Postnatal changes in the cerebral oxygenation in normal and asphyxiated neonates

Using continuous near infrared spectroscopy, we studied postnatal changes in both cerebral hemoglobin oxygen saturation (SbO2) and cerebral total hemoglobin content (THb) in normal and asphyxiated neonates. With normal neonates, THb showed a tendency to decrease within 12 hours after birth. It then remained constant until day 5 but was found to be at a lower level at 1 month after birth. The SbO2 levels remained constant for the initial 5 days but then decreased to lower levels at 1 month. THb and SbO2 levels were higher in moderately and severely asphyxiated neonates than in normal neonates. In one severely asphyxiated neonate, SbO2 was still higher even at 1 month. In another severely asphyxiated neonate, both THb and SbO2 fell after intracranial hemorrhage occurred.