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Modulation of growth of human gastric enterochromaffin-like cells.

We consider the multiple interacting factors which lead to the proliferation of human gastric enterochromaffin-like (ECL) cells, and control of this proliferation by somatostatin and its analogues. Somatostatin receptors occur in human fundic mucosa, and octreotide can be considered a useful therapeutic tool to control gastrin-driven ECL cell growth in humans.