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THE EFFECTS OF NERVE GROWTH FACTOR AND VANILLOID RECEPTOR SUBTYPE 1 ON BLADDER FUNCTION AFTER RELIEF OF BLADDER OUTLET OBSTRUCTION IN RATS

Aims of Study Bladder outlet obstruction (BOO) is a common medical disorder in man that can result from a variety of conditions including benign prostatic hyperplasia, urethral stricture disease, benign and malignant tumors and congenital abnormalities. The observation that 15 to 30% of men after surgical relief of BOO have persistent irritative symptoms should concern clinician.The changes of afferent nerves may contribute to irritative symptoms related to BOO. Nerve growth factor (NGF) is a secretory protein which plays a critical role in the development of the peripheral nervous system including the maturation of sensory pathways. Also NGF has recently been shown to regulate the expression of vanilloid receptor subtype 1 (VR1) mRNA in adult rat dorsal root ganglion neurons and acutely regulate the excitability of afferent receptor. Experimental studies in rats have revealed that alterations in the expression of NGF and VR1 in the bladder after BOO may affect on sensory signalling in the bladder and in turn influence persistent irritative symptoms and unstable bladder. Based on above facts, this study was performed to investigate the changes in NGF and VR1 after relief of BOO and how these changes participate in functional changes of bladder.