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Minimal Alveolar Concentration (MAC) and Dose—Response Curves in Anesthesia

Toads and mice were anesthetized with chloroform, cyclopropane, diethyl ether, divinyl ether, fluroxene, halothane, methoxyflurane, or trichloroethylene in order to compare the concentrations necessary to abolish the righting reflex, the motor response to mechanical stimuli (MAC), respiratory activity, and cardiac function. All four responses could be reproduced within narrow concentration ranges of each anesthetic. However, these concentrations were not the same fraction of MAC with different anesthetics. Thus, with chloroform 1 MAC and with trichloroethylene 0.65 MAC was necessary to abolish the righting reflex in toads. It is proposed that anesthesia involves a number of different effector sites. The authors conclude that the effect at MAC represents the sum of points on two or more dose-response curves.