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Pituitary oncocytic tumor with Cushing's disease

Pituitary adenomas composed of oncocytes are rare. We report a young female with an atypical oncocytic tumor of the pituitary. The histology was unusual because the oncocytic cells—in addition to an abundance of abnormal mitochondria—contained a conspicuous smooth endoplasmic reticulum. The tumor grew invasively and the patient developed adrenal hypercorticism. Cancer 42:1818‐1822, 1978.