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Blood pressure changes in spontaneously hypertensive rats correlate with aortic prostacyclin formation

1 The relationship between the blood pressure fall, induced by antihypertensive drugs or bleeding, and the formation of prostacyclin (PGI2)‐like activity in the thoracic aorta of spontaneously hypertensive rats has been investigated. Inhibition of ADP‐induced platelet aggregation was used to assess PGI2‐like activity. 2 The decreases in blood pressure produced by clonidine, dihydralazine and prazosin were associated with increases of PGI2‐like activity of 50–80%. The increase in PGI2‐like activity correlated well with the blood pressure decrease, independently of the mechanism of the fall in blood pressure.