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Small round blue cell sarcoma of bone mimicking atypical Ewing's sarcoma with neuroectodermal features. An analysis of five cases with immunohistochemical and electron microscopic support

Ewing's sarcoma (ES) of bone may occasionally display rosette‐like textures mimicking Homer‐Wright ones, as seen in neuroectodermic neoplasms (neuroblastoma, peripheral neuroepithelioma). Of a group of 39 cases of ES, reviewed with electron microscopic study, the authors have isolated five atypical ES, which historically also possessed neuroectodermic traces. These tumors were composed of small round blue cells with rosette‐like figures and cytoplasmic glycogen. The immunohistochemical analysis showed positivity for neuron‐specific enolase (NSE) as well as for HNK‐1 (leu‐7) monoclonal antibody. Electron microscopic examination confirmed the tumor cell as being of small round type, with a dense chromatine pattern and the presence of isolated dendritic processes, as well as synaptic‐like buttons; intermediate filaments, neurotubuli, and dense‐core neurosecretory granules also were seen. Moreover, in two cases basement‐like condensations surrounded some cells. Scanning electron microscopic study in one case confirmed the presence of rosette‐like figures and cell elongations with short dendritic projections of the cytoplasm. Clinically and radiologically these cases showed features similar to ES of bone; one case, located in the chest wall, had a local relapse after treatment, with the histologic features of a pleomorphic neuroblastoma. The authors conclude that these tumors resemble closely immature neuroepithelioma of soft tissue but, being primary to bone, are superimposable on those described as “neuroectodermal tumors of bone.”