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Monolayer Cultures of disaggregated human adipocytes

Two theories of adipose cell origin have been proposed. One suggests that they develop from specialized anlage whose cells spread throughout the body and accumulate fat. The other holds that they form by accumulation of fat in unspecialized cells of connective tissue. Each theory has some experimental support.Animal adipose cells have been grown readily in tissue culture but, human adipocytes have been more difficult to grow. This study was undertaken in an effort to understand the origin of adipocytes and their relationship to obesity. Disaggregrated adipose cells taken from human infants of different ages were grown in tissue culture. Under conditions of culture used the cells changed from their usual spherical to a fibroblast appearance, gradually lost intracellular lipids, then divided. Adipocytes from older children also changed shape, lost intracellular lipids more slowly but were not observed to divide.These findings, while shedding no light on the origin of adipocytes, suggest that their ability to divide may depend, at least in tissue culture, on the donor age.