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Genome-wide complex trait analysis (gcta) for complex traits including major depressive disorder and smoking

GCTA We used the software program Genome-wide Complex Trait Analysis (GCTA) to estimate phenotypic variance due to the genotyped SNPs (Yang, J., Lee SH, Goddard ME, Visscher PM, Am J Hum Genet 2011; 88: 76-82). The method involves calculating the genetic similarity between all pairs of subjects based on all measured SNPs, which is then used to predict the phenotype. We compare the estimated additive genetic variance to estimates of heritability obtained in twin families from the same population.