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Familial glaucoma. In nine generations of a South Hampshire family.

A. Zorab (1932) reported a family suffering from "glaucoma simplex familialis" over three generations, the inheritance being autosomal dominant. Over the last 40 years, the various branches of this family have increased in number and two further generations have been added. In addition, four affected generations before those reported by A. Zorab (which he did not know about) have now been discovered. The purpose of this paper is to report the full extent of the pedigree of this family as far as is now known, and to describe the manifestations of this particular familial chronic glaucoma and the way in which the disease progresses and responds to treatment. The glaucoma is associated with an abnormally developed iris and angle, but behaves rather like chronic simple glaucoma.