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Protein Composition of PNS Myelin: Developmental Comparison of Control and Quaking Mice

Abstract: Protein compositions were determined for sciatic nerve myelin isolated from young and adult control and quaking (Qk) mice. Age‐related changes in the relative amounts of large (P1) and small (Pr) basic proteins were found. In control animals, the ratio Pr/P1 increased with age, a change similar to that observed for the large (B1) and small (Bs) CNS myelin basic proteins of adult mice. Pr/P1 also increased with age in the Qk mouse sciatic nerve, but only to the point that the value in the adult Qk mouse was similar to that observed for young control animals, a situation reminiscent of the effect of the Qk mutation on CNS basic proteins. Thus, our data suggest that the Qk mutation has a similar effect on peripheral nervous system (PNS) and CNS basic proteins. Our findings are consistent with recent electrophoretic and immunochemical data showing that PNS and CNS myelin basic proteins in rodents are analogous, and they suggest that the genetic program controlling basic protein expression is common to oligodendroglia and Schwann cells.