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Assessing the generalizability of findings from the Alzheimer’s Disease Neuroimaging Initiative to the Atherosclerosis Risk in Communities study cohort

The Alzheimer’s Disease Neuroimaging Initiative (ADNI) collects and shares high quality imaging, biomarker, genetic, and clinical data. Whether findings from ADNI generalize broadly is unclear, given its highly‐selected, predominantly white and well‐educated participants. We compared associations estimated in ADNI to those estimated in the Atherosclerosis Risk in Communities (ARIC) study, which initially recruited participants randomly from four US communities, to examine the potential generalizability of ADNI findings.