{'fraction_non_alphanumeric': 0.07372708757637475, 'fraction_numerical': 0.0615071283095723, 'mean_word_length': 4.975669099756691, 'pattern_counts': {'":': 0, '<': 6, '<?xml version=': 0, '>': 1, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
1580: RISK FACTORS ASSOCIATED WITH SEPSIS IN CANCER PATIENTS ADMITTED TO THE ICU: A CASE-CONTROL STUDY

Introduction/Hypothesis: Cancer patients are at high risk of developing sepsis. However, epidemiological and prognostic data in South American patients is limited, and studies relating both diseases have been mostly carried out in developed countries. Therefore, a Case-Control study was conducted to determine risk factors associated with sepsis in oncological critically ill patients in Ecuador. Methods: A Case-Control Study of adult cancer patients admitted to the Intensive Care Unit (ICU) at the SOLCA Hospital in Guayaquil, Ecuador during 2018. Electronic medical records were reviewed. We compared the septic (cases) and non-septic patients(controls). Statistical analyses were calculated using SPSSv24. Results: A total of 164 patients were included, 55(33.5%) were septic and 109(66.5%) were controls. Overall, the mean age was 54.5, and most of them were female (70%). The most common comorbidities were hypertension (36%) and diabetes (15%), and the main cause of ICU admission was septic shock (74.54%) and postsurgical (62.38%) for the septic and controls, respectively. The septic patients had higher severity of illness scores at admission with a mean Sequential Organ Failure Assessment (SOFA) of 6.45 vs 3.69(p<0.01), and the mean APACHE score 21.78 vs 16.88(p<0.01). In regards to the risk factors, neither obesity (BMI>30 kg/m2) or underweight (BMI<18.5 kg/ m2) significantly modified the risk for sepsis. Patients with hematologic malignancies (OR=6.38; 95%CI=2.14-19), neutropenia (OR= 3.86; 95% CI=1.49-10.02), and thrombocytopenia (OR=3.35; 95%CI=1.6-6.7) were at higher risk for sepsis. Conversely, solid tumors had a protective effect against sepsis (OR=0.16; 95%CI=0.05-0.46), but having metastatic disease rose the risk (OR=3.28; 95%CI=1.54-6.98). The mortality rates were higher for the septic patients compared to the non-septic counterparts. For instance, the ICU mortality was 32.14% vs 16.6%(p<0.01), hospital mortality 42% vs 20.3%(p<0.01), and 28-day mortality 35.7% vs 18.51% (p<0.01). Conclusions: Hematologic cancer, metastatic disease, thrombocytopenia, and neutropenia were risk factors for sepsis in oncological patients admitted to the ICU. Septic patients had almost a twofold increase in mortality rates than non-septic patients. Further research in South America should assess this understudied population.