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[On Synergism of Potassium and Magnesium in Maintenance of Myocardial Function].

AIM
systematization of studies of synergistic effect of potassium and magnesium on myocardial function.


MATERIAL AND METHODS
Analysis of an array of literature using methods of computer learning.


RESULTS
Synergism of potassium and magnesium is driven by common causes of deficit (low content in diet, abnormal renal function, iatrogenic causes), by potassium sparing effects of magnesium, and by regulatory properties of magnesium in processes affecting potassium binding proteins (first of all potassium rectifier channels). Magnesium and potassium exert substantial synergism in maintenance of cardiac rhythm (in particular preventing QT prolongation) and in cardioprotection. Combination administration of organic potassium and magnesium salts was shown to be effective for urgent therapy and long term prevention both as intravenous and oral formulations.