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Cardiovascular reactions to anaesthesia during treatment with levodopa

Levodopa is the most effective treatment for a considerable number of Parkinsonian patients. However, reversible dose-dependent adverse reactions are frequently encountered. Hypotension is common.' Hypertensive reactions have also been recorded.2 It has therefore been recommended that, in patients undergoing surgery, levodopa should be stopped 24 hr before the administration of a general anaesthetic. In the following report, an account is given of two patients undergoing anaesthesia whilst being treated with levodopa. During the post-operative period one of these patients became hypotensive and the other became hypertensive.