{'fraction_non_alphanumeric': 0.05892047795632468, 'fraction_numerical': 0.05892047795632468, 'mean_word_length': 5.024813895781637, 'pattern_counts': {'":': 0, '<': 3, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
343: COMPARING THE CLINICAL UTILITY OF 30-DAY MORTALITY RISK STRATIFICATION TOOLS IN SUSPECTED SEPSIS

Learning Objectives: Critical illness in cancer patients remains associated with poor outcomes. We aimed to study the factors associated with survival in cancer patients with septic shock. Methods: We included a cohort of survivors and non-survivors admitted with the diagnosis of septic shock to an oncologic ICU between 4/1/2016 and 3/31/2017. We collected demographics, severity of illness score, resource utilization, and outcomes. Statistical analyses were performed using SPSS v 25. Results: Among the 223 patients with septic shock, 128 patients (57.4%) died within their ICU admission. There were no differences in cancer type or stage, treatment response, number of relapses, or disease activity. Additionally, there were no differences in age, sex, race, admission laboratory tests, body mass and Charlson’s Comorbidity indices between these two populations of survivors and nonsurvivors. Survivors required significantly less mechanical ventilation (51.6% v 85.9%, p=<0.0001) and less episodes of bleeding requiring transfusions (20.0% v 37.5%, p=0.005). There was no difference in terms of hemodialysis (p=0.276) or red blood cell transfusion requirements (p=0.360). The non-survivors were significantly sicker on admission with mean SOFA score of 10.2 versus 8.7 versus (p=0.002) and remained sicker throughout admission with max SOFA scores of 14.8 versus 11.5 (p=<0.0001). ICU mean LOS was 12.5 versus 10.1 (p=0.213), and mean hospital LOS was 35.5 versus 32.3 (p=0.021) respectively. The survivors lived an average of 192.8 days post discharge. The survivors required significantly less time on vasopressors (2.8 vs 4.3 days, p=0.003). The ventilation time requirements for the two groups were similar (10.5 vs 11.1 days; p=0.750). There was no difference between the two groups regarding urosepsis or bacteremia (p=0.141, p=0.104). However, nonsurvivors had an increased proportion of positive respiratory isolates (63.3% v 36.8%, p=<0.0001) and other body positive cultures (p=0.007). Conclusions: Survivors and nonsurvivors had similar baseline demographics and oncologic history. However, nonsurvivors had higher severity of illness scores throughout their ICU stay. In addition, nonsurvivors had more bleeding episodes, more positive respiratory cultures, and required more invasive ventilation support.