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Expression of T‐cadherin in a hereditary hypercholesterolemic swine model

Decreased adiponectin levels correlate with reduced vascular function and increased CAD. T‐cadherin is a major receptor for adiponectin in the vasculature. To evaluate the expression of Tcadherin in athero‐prone and athero‐resistant arteries of a hereditary hypercholesterolemic (HH) swine model of atherosclerosis. We tested the hypothesis that exercise training would increase the expression of T‐cadherin in atherosclerotic lesions of HH swine. Fifteen HH pigs were randomly assigned into either exercise trained (EX) or sedentary groups (SED). Exercise training consisted of a 16 week progressive treadmill training program. LAD, RCA and internal mammary artery (IM) were harvested. IHC was performed in the entire vessel wall in order to quantify the presence of T‐cadherin. The average percentage for Tcadherin staining was significantly higher in the athero‐resistant IM. Expression of T‐cadherin tended to be greater in LAD, RCA and IM from EX pigs. The differential expression of T‐cadherin between coronary and mammary arteries may in part mediate their opposite response to a pro‐atheroslcerotic stimulus, and that endurance training seems to enhance the levels of T‐cadherin of this model of disease. Supported by NIH HL52490.