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In response: Hyperoncotic albumin is not effective in the treatment of peripheral oedema

The take-home message in our article was that microcirculatory findings made in highly controlled experimental situations with frogs and rats should be validated in humans before being used to guide fluid therapy in humans.1 We provided substantial evidence for transcapillary refill, and we cited the utility of hypertonic solutions for enhancing fluid recruitment, as demonstrated in human subjects. The aim was not specifically to discuss the pros and cons of colloids, and we did not justify their use. Our focus was on discussing the fundamental physiological implications of the glycocalyx in fluid distribution.