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To what extent can plasma supply for factor VIII production, be obtained within the frame of a blood component program?

A country's total need of plasma for the production of Factor VIII preparations can be covered completely within an efficient blood component program, but only under certain conditions. 
 
 
 
If the need of Factor VIII is 2 IU per inhabitant and the final yield of Factor VIII:C in the preparation is 30% of original, fresh plasma from 50% of the blood units is sufficient at an annual blood collection rate of 50,000 per million inhabitants. These figures are realistic in a cryoprecipitate program and allow sufficient plasma for substitution of plasma protein loss in other medical care than hemophilia. 
 
 
 
In a program with predominantly high-purity Factor VIII concentrates, additional plasma must be obtained by plasmapheresis or overcollection due to the present lower final yields in these products.