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A Microfluidic Impedance Flow Detection Platform Based on Rapid PolyJet 3D Printing Fabrication Toward Biomedical Analysis Applications

Limited manufacturing technology and upscaling potential are the main obstacles in bringing microfluidic devices into real-life applications. This study presents a combinative approach using 3D printing and printed circuit board (PCB) technologies to solve the problem. A lab-on-printed circuit board (LoPCB) microfluidic device with the ability to generate microdroplets was successfully designed and fabricated to confirm the performance of the proposed rapid fabrication method. The device’s operation was investigated. The proposed rapid prototyping does not require a cleanroom as in general approaches for microfluidic fabrication. The experimental results of microdroplet generation and impedance fluidic flow detection on fabricated devices have proved that the combination of 3D printing and PCB technologies was simple and easy. The use of polydimethylsiloxane (PDMS), a bio-compatible material, enables the application of bio- component sensing using the electrical approach by the proposed fabrication technique. It is highly feasible to apply in microfluidic devices aiming for compact lab-on-a-chip (LoC) systems in biomedical analysis applications.