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Primary infertility: correlation between sperm migration test and humoral immunity.

Eleven couples with unexplained primary infertility were studied. The only abnormality appeared to be a poor sperm migration test (P.S.M.T.). The importance of circulating immune factors in these couples was assessed using a modified Kibrick test. Control sera included four provided by the WHO, four of our known positive samples, 49 sera obtained prevasectomy, and 17 sera collected from infertile couples with organic female pathology. A positive titer was found in one out of 49 control sera before vasectomy and in four out of 17 control coupled with organic female factors. In the 11 couples with poor sperm migration test, the titer was positive in two female and three male subjects. The wives of two of these male subjects with a positive titer became pregnant without any therapy. These results cast some doubts about the predictive value of such a test.