{'fraction_non_alphanumeric': 0.042114695340501794, 'fraction_numerical': 0.017921146953405017, 'mean_word_length': 5.240223463687151, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Estrogen receptor in rabbit ovaries and effects of antiestrogen on progesterone production.

The present experiments examine the hypothesis that in pseudopregnant rabbits, a dramatic steroidogenic effect of estradiol on ovarian progesterone production is mediated by the estradiol-receptor complex mechanism. Such a hypothesis predicts that 1) estrogen receptor in the corpus luteum would accumulate rapidly in the cytosol after removal of a chronic Silastic capsule source of estradiol, and 2) the antiestrogen CI-628 (l-[2-(p-[α-(p-methoxyphenyl)β-nitrostyryl]phenoxy)-ethyl]pyrolidine monocitrate) would block the rescue of progesterone production that occurs upon reinsertion of the estradiolfilled capsules. Superovulation was induced, and on the second day after hCG (day 2), an estradiol-filled capsule was inserted beneath the skin in each rabbit. Progesterone in peripheral serum was 26 ± 4 ng/ml (mean ± SEM) on day 9 when the estradiol-filled capsule was removed; serum progesterone then declined to 7 ± 2 ng/ml within 18 h (day 10). Available cytoplasmic estrogen receptor in the corpus luteum was 799...