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Differences in the Quantitative Distribution of Lysine-Rich Histones in Neoplastic and Normal Tissues 1

Summary The data obtained in the present study show that neoplastic tissues of the rat and calf contain the normal complement of lysine-rich histones, and that there are distinct quantitative differences between certain of the corresponding components of neoplastic and normal tissues. These results are discussed in relation to the postulated roles of histones as regulatory and/or structural elements of the genetic apparatus in higher organisms.