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Clinical indicators for common paediatric conditions: Processes, provenance and products of the CareTrack Kids study

Background In order to determine the extent to which care delivered to children is appropriate (in line with evidence-based care and/or clinical practice guidelines (CPGs)) in Australia, we developed a set of clinical indicators for 21 common paediatric medical conditions for use across a range of primary, secondary and tertiary healthcare practice facilities. Methods Clinical indicators were extracted from recommendations found through systematic searches of national and international guidelines, and formatted with explicit criteria for inclusion, exclusion, time frame and setting. Experts reviewed the indicators using a multi-round modified Delphi process and collaborative online wiki to develop consensus on what constituted appropriate care. Results From 121 clinical practice guidelines, 1098 recommendations were used to draft 451 proposed appropriateness indicators. In total, 61 experts (n = 24 internal reviewers, n = 37 external reviewers) reviewed these indicators over 40 weeks. A final set of 234 indicators resulted, from which 597 indicator items were derived suitable for medical record audit. Most indicator items were geared towards capturing information about under-use in healthcare (n = 551, 92%) across emergency department (n = 457, 77%), hospital (n = 450, 75%) and general practice (n = 434, 73%) healthcare facilities, and based on consensus level recommendations (n = 451, 76%). The main reason for rejecting indicators was ‘feasibility’ (likely to be able to be used for determining compliance with ‘appropriate care’ from medical record audit). Conclusion A set of indicators was developed for the appropriateness of care for 21 paediatric conditions. We describe the processes (methods), provenance (origins and evolution of indicators) and products (indicator characteristics) of creating clinical indicators within the context of Australian healthcare settings. Developing consensus on clinical appropriateness indicators using a Delphi approach and collaborative online wiki has methodological utility. The final indicator set can be used by clinicians and organisations to measure and reflect on their own practice.


Introduction
Despite efforts aimed at achieving quality, equity, and sustainability of healthcare systems [1][2][3][4][5], gaps remain between the care that is recommended (appropriate care, in line with evidence and/or clinical practice guidelines (CPGs)) and that which is delivered [6,7]. To prioritise resources and develop strategies to address the inappropriateness of and variations in care [8], national measurement and monitoring activities are needed to capture what population-level care is given, and by whom [9][10][11][12]. Internationally, clinical standards and indicators are increasingly being used to identify gaps and areas for improvement, and understand and measure the quality of healthcare provided [13][14][15][16][17][18][19][20][21][22]. Data evaluating appropriateness of healthcare for children is limited, especially at population level [23,24].
As interpretation of performance measured by clinical indicators can have far-reaching consequences (e.g. public reporting, pay-for-performance), it is important to ensure that they are developed in a way that reflects what is reasonably expected of clinicians [57]. For example, for the purposes of a medical record audit, this may be best achieved through combining consensus-based (i.e. stakeholder perspectives / expert opinion) and CPG-driven (i.e. recommendations to clinicians to guide care). The Delphi technique, a structured process comprised of several rounds of review to gather stakeholder perspectives until consensus is reached [17], can be used to vet recommendations derived from CPGs to develop healthcare quality indicators [17]. While a number of studies have used combined methods to create clinical indicators, of these most focus on a single condition [58,59], clinical area or care process [60,61] or healthcare setting [62,63].
Built on the findings and experience of the CareTrack Australia study [11,51], the objective of the CareTrack Kids study was to determine the appropriateness of healthcare delivered to children in Australia for common conditions [64]. This paper describes a core component of the CareTrack Kids study; the development of a set of clinical appropriateness indicators for common paediatric conditions for use across a range of healthcare practice facilities, including primary care provided by general practitioners, secondary care provided by outpatient paediatricians and tertiary care in hospitals [65]. Our method married recognised Delphi processes [17] with a collaborative online wiki [66] to achieve consensus on what constitutes appropriate care, using CPGs as a primary information source. We report on this indicator development; detailing the processes (panel recruitment; methods of indicator development and criteria for selection), provenance (origin and evolution of original recommendations and indicators throughout the study including reasons for exclusion) and products (characteristics of the final set of indicators including linking these to evidence levels and grades of recommendations).

Methods
The three components of our indicator development work [65] were to (1) identify and select common candidate paediatric conditions (presented in our study protocol [65]), (2) develop clinical indicators representative of "appropriate care" for these conditions, and (3) refine them for feasibility, applicability and utility. Our approach has been described in our study protocol [65]. Terms used in CTK and their definitions are presented in Box 1. This study was Box 1. Definitions of terms used in the CareTrack Kids study.
A clinical practice guideline (CPG): "Statements that include recommendations intended to optimise patient care that are informed by a systematic review of evidence and an assessment of the benefits and harms of alternative care options." [67,68] A clinical standard [11]: • is an agreed process that should be undertaken or an outcome that should be achieved for a particular circumstance, symptom, sign or diagnosis (or a defined combination of these) approved by the Macquarie University Human Research Ethics Committee (protocol 5201401120). [65] We initially identified 21 common paediatric conditions (Box 2). Clinical indicators representative of their appropriate care were developed, using a four-stage process: 1. systematic search and source relevant CPGs; 2. select, draft and format proposed clinical indicators; 3. review indicators internally and externally (via a modified Delphi approach); and 4. refine and convert indicators to individual medical record audit indicator items suitable for use in a wide range of circumstances [64].
• should be evidence-based, specific, feasible to apply, easy and unambiguous to measure, and produce a clinical benefit and/or improve the safety and/or quality of care, at least at the population level.
If a standard cannot or should not be complied with, the reason/s should be briefly stated.
A clinical indicator [11]: • describes a measurable component of the standard, with explicit criteria for inclusion, exclusion, time frame and setting.
A clinical tool [11,[69][70][71][72]: • should implicitly or explicitly incorporate a standard or a component of a standard • should constitute a guide to care that facilitates compliance with the standard • should be easy to audit, preferably electronically, to provide feedback • should be able to be incorporated into workflows and medical records.
Appropriate care [11,51,73]: • care in line with evidence-based or consensus-based guidelines A wiki [66,74,75] • is an interactive information management system which will allow users (e.g. healthcare professionals who register for, and login to the wiki) to collaborate directly in formulating and refining indicators that are relevant to their clinical practice and lived experience.
Underuse [76] "Failure to deliver a service that is highly likely to improve the quality or quantity of life, that represents good value for money, and that patients who were fully informed of its potential benefits and harms would have wanted." Overuse [76] "Provision of a service that is unlikely to increase the quality or quantity of life, that poses more harm than benefit, or that patients who were fully informed of its potential benefits and harms would not have wanted."

Stage 1 Search and source relevant CPGs
Clinical indicators were derived from published CPGs relevant for 2012 and 2013. A systematic search was undertaken, in order of priority, for national-level CPGs from Australia (e.g. from the National Health and Medical Research Council (NHMRC)) [77], and internationally [78][79][80]. In the absence of Australian, national or international CPGs, those from relevant professional medical colleges and associations were examined, as well as those from state jurisdictional bodies or professional groups [81,82]. Three Research Group members (LKM, TDH, PDH) conducted the CPG searches and developed the initial set of clinical indicators. Full details of the search strategy are provided in online S1 • Strength/certainty of the wording of the recommendation (i.e. "may", "could" and "consider" statements were excluded) • Low likelihood of information being documented in the medical record • Guiding statements without recommended actions • Out of scope of the CTK study (i.e. "structure-level" recommendations aimed at attributes of the settings in which care is delivered [12,43]).
All clinical indicators were written in a structured and standardised format, commencing with the inclusion criteria followed by the compliance action [51]. For example, the inclusion criteria defined the age (infant, child, adolescent), condition, and the phase of care (at diagnosis/presentation or "with", indicating the diagnosis is existing). The compliance action defined the recommended appropriate care. Indicators were arranged chronologically according to phases of care (Table 2).

Stage 3 Subject the indicators to several rounds of internal and external review
There were two stages involved in the indicator review (Fig 1). The proposed clinical indicators were subjected to an internal review (Stage 3a), followed by an external wiki style review (Stage 3b) using a modified Delphi process [87]. This multi-round, multi-modality approach aimed to enhance methodological rigor and optimise consensus with respect to the content and face validity of the final set of clinical indicators [17]. We conducted three rounds for the internal review (Stage 3a), and two rounds in the external review (Stage 3b).

Stage 3a Internal review processes
In accordance with selection strategies employed within the Delphi process literature [17,88], internal reviews were conducted by paediatricians and general practitioners who were Table 1. Examples of current recommendations which would meet exclusion criteria.

Example exclusions Rationale for exclusion
Strength/certainty of wording Healthcare professionals who routinely use disposable chemical dot thermometers should consider using an alternative type of thermometer when multiple temperature measurements are required [83].
Use of term "consider" does not provide a certain or conclusive action against which medical record compliance can be assessed

Likelihood of documentation
People with autism are not prescribed medication to address the core features of autism [84] The rationale for prescribing medication in this context is unlikely to be documented in a medical record Guiding statement without recommended action Be aware that the aim of weight management programmes for children and young people can vary. The focus may be on either weight maintenance or weight loss, depending on the person's age and stage of growth [85].
Guiding statement with no specific actions able to be used to determine compliance Out of CTK scope Streamlined referral pathways should be developed for tests not available or appropriate in primary care [86] identified by the research team and their professional networks. Clinical Champions, who led the internal review panel members, were employed as the head or director of a relevant paediatric department in a large hospital, held at least an adjunct academic appointment or were directly involved in clinical care. The clinical indicators for each condition were reviewed via email by a panel of at least three reviewers. Reviewers completed their assignments independently to minimise bias from "group-think" [89,90].
The review criteria were based on methods developed in previous US and Australian studies[23, 49, 51]. Internal reviewers were asked to: score each indicator using one of three responses (yes, no, not applicable to area of expertise or clinical setting) against three key criteria; acceptability, feasibility and impact (Box 3) [65]; to recommend the indicators for inclusion or exclusion; and provide any additional comments. Research Group members (LKW, TDH, PDH) collated the feedback and revised the content, structure, and format of each indicator between review rounds.

Stage 3b external wiki-based review
External reviews were conducted by invited paediatricians and general practitioners. Relevant medical colleges, professional associations and networks were contacted, requesting assistance with the recruitment of clinical experts to register as external reviewers. Invitations comprised direct email requests to members, media releases and articles within newsletters. Clinical experts self-nominated as reviewers for one or more of the CTK conditions based on their interest, scope of practice and clinical experience [17,88]. All reviewers were required to complete a Conflict of Interest (COI) declaration [91][92][93]; COIs were recorded for each reviewer and managed according to the NHMRC protocol [94].
Indicators for each condition (from round three of the internal review) were posted to an online wiki site. The aim was for each condition to be independently reviewed by a minimum of nine experts. In addition to the scoring criteria used in the internal review process, indicators were scored on a nine-point Likert scale as representative of appropriate care delivered to children during 2012 and 2013 [23,51,95]. With the support of a Research Group member as a wiki site Administrator, the Clinical Champion for each condition followed-up and managed external reviewers' responses, and made final recommendations regarding the inclusion, content, structure and format of indicators (Table 3). For most conditions, the Clinical Champion's role was undertaken by one of the Stage 3a internal reviewers. In the second wiki round, experts had access to de-identified comments from the first round.

Asthma Treatment
Patients who presented to an emergency room or to their GP with an exacerbation of asthma and a PEFR/peak flow or FEV1 less than 70% of baseline were prescribed an inhaled corticosteroid (106).

Diabetes
Ongoing management Patients with existing type 2 diabetes were referred to a dietician or provided with dietary advice every year (360). Consensus business rules. For the Stage 3 internal and external reviews, consensus was defined as the majority agreeing to include or exclude; when a clear majority was not able to be achieved we opted to retain the indicator and subject it to additional feedback over subsequent rounds of review. In order to facilitate consensus, the Research Group and wiki Administrator and Clinical Champion used comments fields to provide indicator reviewers with a summary of the feedback obtained to date, where relevant Box 3. Information for scoring criteria for clinical indicators [65] Acceptability (A) • Level of evidence or grade of recommendations. In some instances a level of evidence or grade of recommendation may not have been provided. In these cases, absence of evidence should not be the only grounds for exclusion of the indicator (i.e. expert consensus may be acceptable).
• Non-Australian clinical guideline recommendations. There are some indicators where the primary source is a non-Australian clinical guideline from a reputable organisation (e.g. NICE). In the absence of Australian guidelines, it is important to consider whether such a guideline reflects what is practical within the context of Australian healthcare settings.
• Non-national Australian clinical guideline recommendations. In the absence of nationally-based Australian AND international guidelines, some indicators have been sourced using guidelines from one state or organisation e.g. NSW Health, or Royal Children's Hospital in Melbourne.
• Recommendation is made in more than one clinical guideline.

Feasibility (F)
• Indicators with multiple eligibility criteria tend to have lower numbers of eligible encounters.
• Compliance can be determined preferentially from one encounter with one healthcare provider, or at least within a 1-2 year period (our sample will be the medical records of healthcare encounters for children during the 2012-2013 period).
• Likely to be documented in the medical record, for example: indicators associated with lifestyle or exercise advice are less likely to be documented.

Impact (I)
• "High impact" on the patient in terms of domains of quality i.e. safety, effectiveness, patient experience, or access.
• "High impact" within Australian healthcare settings (e.g. what will be the frequency/ prevalence of presentation).

Stage 4 Refine and convert indicators to individual medical record audit indicator items
During the Stage 4 refinement process, we flagged indicators with an appropriateness score of less than 7, or more than three inclusion criteria, as these are likely to have lower prevalence, and sought the condition Clinical Champion's approval for their exclusion. For all indicators approved for inclusion, the Research Group converted each inclusion criterion and compliance action into an individual medical record audit indicator item and formatted these such that "not applicable" (i.e. medical record did not meet the indicator's inclusion criteria) or binary responses (yes/no) could be recorded (S1 Table). We also analysed the final set of indicators to ensure all phases of care were covered, and that the relevant indicators were 'feasible' for the main medical record audit [64]. Each Clinical Champion checked the individual medical record audit indicator items for their nominated condition to ensure the 'spirit' of the original recommendations and reviewers' feedback from previous rounds had been accurately captured.

Data analysis
Reviewers' scores and comments from the internal (manually entered) and external (exported from the wiki) reviews were entered into Microsoft Excel (2013) spreadsheets. Analysis and reporting of study data is in the form of descriptive statistics for the resultant processes, provenance and products.

Processes
A panel of 24 experts completed the internal review; each condition was allocated at least three reviewers, and each reviewer undertook reviews for no more than three conditions. For the external review, 79 participants registered and were approved for the wiki site; 37 (47%) undertook the Round 1 review for their nominated condition(s), and 24 (30%) went on to complete Round 2. The demographic characteristics of indicator reviewers are presented in Table 4. In the external review, there was a mean of 5 (SD 2.7) reviewers per condition (range 1-14; median 4) (S1 Table).

Provenance
We identified 113 relevant CPGs with supporting references, from which 1432 original recommendations were extracted. Over one-fifth of extracted recommendations (n = 334, 23%) were initially excluded by the Research Group (S2 Table). The information contained in some of Clinical indicators for paediatric conditions: Processes, provenance and products of the CareTrack Kids study these exclusions was covered in other recommendations which were included in our sample (n = 86 of 334, 26% of guiding statements; and n = 3, 4% of those excluded due to strength/certainty of wording) (S2 Table). In addition, a small proportion of the excluded guiding statements (n = 3, 1%) were incorporated into definitions which were to be provided to research surveyors to assist them in completing the medical record audit. The remaining original recommendations (n = 1098) were used to draft 451 proposed indicators for circulation among the internal review panel members (Fig 2). Following three rounds of internal review, almost half were rejected (n = 206, 46%) mainly due to concerns around the feasibility of capturing indicator information by way of a medical record audit (e.g. likelihood of the necessary documentation being present) (S3 Table). During the internal review, 245 indicators were approved for posting to the wiki for the external review, together with twenty-one 'new' indicators (S4 Table) developed by splitting existing indicators which contained more than one eligibility criterion and/or compliance action. The external review yielded 257 indicators (97%), with the main reasons for exclusion mirroring those from the internal review (Fig 2). S5 Table and Fig 3   Clinical indicators for paediatric conditions: Processes, provenance and products of the CareTrack Kids study

Products: Indicators and medical record audit indicator items
The final 234 indicators were used to develop 597 individual medical record audit indicator items for the medical audit review (Table 5, S1 Table). In terms of classification according to phase of care, most medical record audit indicator items related to 'treatment' (n = 273, 46%) (S6 Table). Most items were geared towards capturing information about under-use in healthcare (n = 551, 92%) across emergency department (n = 457, 77%), hospital (n = 450, 75%) and general practice (n = 434, 73%) healthcare facilities, and were based on consensus level recommendations (n = 451, 76%).

Discussion
To our knowledge, this is the first study to detail the processes, provenance and products of developing clinical indicators of appropriate care for a range of common paediatric conditions for use across Australian primary, secondary and tertiary healthcare practice facilities. Paediatric indicator development studies over the last decade have focused on fewer paediatric conditions[23, 96,97] or specific types of illnesses and/or healthcare practice facilities [96][97][98][99]. Our methodology was strengthened by employing a transparent, multi-stage and multi-modality modified-Delphi process which aimed to contextualise the recommendations published in CPGs (including scientific evidence) to the clinical setting (expert opinion). The Delphi procedure was reported in accordance with current recommendations[17] (S7 Table). Using our approach and definitions, we were able to achieve consensus on appropriate care for 21 paediatric conditions (in Australia for the years 2012-2013), and embody these in clinical indicators. Clinical indicators for paediatric conditions: Processes, provenance and products of the CareTrack Kids study The main reason for excluding indicators was feasibility which included multiple eligibility criteria, compliance unlikely to be determined during a medical record audit, low likelihood of information being documented (Box 3, Fig 2), and is supported by internationally-recognised organisations [22] and literature [17]. A potential consequence of this is that using 'feasibility' as an eligibility criterion may serve to drag down the standard of measuring what is deemed appropriate care towards the care we are expecting to be documented rather than that which should be delivered. Recommendations were also excluded due to the strength/certainty of their wording (e.g. "may", "could", "consider" statements), which means that our indicator set did not cover aspects of care that may be influenced by situational factors and/or patient preferences; this presents a gap in their clinical utility. A first step to capturing information about these aspects of care is improving the detail and consistency of clinicians' documentation (e.g. consideration of differential diagnoses, decision making based on situational factors and/or patient preferences). In the future, and as standardised electronic medical records become more commonplace and sophisticated, this may be facilitated by structured and mandatory fields of entry [11], as well as shared access and decision-making between patients and clinicians using integrated electronic apps and medical record software to inform, guide and record care; and especially variations in care as a result of situational factors or preferences [100,101].
Application of the CTK indicators for research purposes has been described in the main results paper [102] and a condition-specific analysis for tonsillitis [103]. While originally developed for use in a large-scale research medical record audit, the CTK indicator set can be used by clinicians and organisations to measure and reflect on their own local practice (Table 6). In this way, data can be aggregated by individuals or groups of practitioners, hospital Table 5

Indicator Item no. Item Rationale
Children aged between 2-16 years are diagnosed as follows: overweight (if BMI for age and sex in 85th -94th percentile) OR obese (if BMI for age and sex greater than 95th percentile).
OBES01 Children aged between 2-16 years with a BMI for age and sex in 85th -94th percentile were diagnosed as overweight.
Multiple inclusion criteria and compliance actions OBES02 Children aged between 2-16 years with a BMI for age and sex greater than 95th percentile were diagnosed as obese.
Children Compliance action • The number of patients within a sample whose care was adherent to the compliance action form the numerator in calculations of percentage adherence departments and local or jurisdictional health networks to determine baseline adherence with recommended care [104][105][106], and identify and target practice gaps with professional development and other quality improvement activities. For aspects of care that are not covered by the current CTK indicator set, supplementary data collection methods such as case studies, patient satisfaction surveys, narrative-text analyses of clinical notes, and clinician/patient interviews may need to be considered [107].
There are several caveats to our findings. First, the final set of clinical indicator items was based on recommendations in CPGs relevant for the years 2012-2013, with priority given to those published in Australia. While this limits the applicability and generalisability of the indicators beyond these contexts, they do provide a basis from which new indicators may be derived and adapted to local settings. We did not critically appraise the quality of included CPGs; for three conditions (i.e. acute abdominal pain, head injury, and preventive care) we were unable to identify CPGs where "a systematic review of evidence and an assessment of the benefits and harms of alternative care options" had been undertaken by the CPG developers to inform the recommendations [67,68]. As a result, we accepted CPGs and protocols for managing care produced at state, national or local hospital level which means that there was little depth to the evidence base underpinning the indicator sets for these three conditions. Grades of recommendation and levels of evidence were recorded verbatim from included CPGs. CPGs did not consistently report sufficient information about the primary evidence or decision-making used to formulate recommendations to allow the author team to uniformly apply an established evidence grading system to extracted recommendations, such as GRADE [108]. As a reflection of the CPGs from which they were born, the majority of medical record audit indicator items were based on consensus-level recommendations and pertained to under-use (S6 Table). However, in recent years there has been growing awareness of 'overuse' of healthcare resources(6, 9, 76, 104, 105) and to perceive this as a source of not only waste but of healthcare related harm (11,106). We found 45 (8%) of our indicator items sought to evaluate some aspect of over-use. A range of national standards and accreditation processes (e.g. Choosing Wisely(109)) are working to champion reduction of over-use and unwarranted healthcare variation(3, 14) and low value care(9, 15).
Second, the indicators represent the opinions of individuals who chose to participate in this study. Internal review panel members were non-randomly selected for invitation, and external reviewers were targeted through relevant medical colleges, professional associations and networks which may have skewed our sample or amplified any effects of self-selection bias. We met our goal of achieving at least nine external reviewers for only one (BRON) of the 21 conditions (S1 Table); attracting a lower critical mass of experts than expected may limit the face validity of our indicator sets when applied to the clinical setting (e.g. response bias, non-representative process measures, reduced endorsement and uptake in the wider community) [109,110].Tempering this, our internal review panel had extensive clinical and quality improvement experience in paediatric care in Australia, and most external reviewers had university-based affiliations in addition to their clinical roles which may have assisted to refine the indicators in a manner underpinned by both scientific evidence and clinical experience. Importantly, paediatricians working in hospital settings dominated our expert panels; their review of clinical indicators geared towards capturing information about care provided in general practice may have lacked relevance. Patient and public involvement in guideline development aims to improve patient-centred health care provision, foster democratic healthcare policy-making, and enhance the quality of healthcare and related policy [111]; CTK indicators were developed without patient consultation, which is a limitation of our process.
Third, we did not formally evaluate the methodological rigor of our indicator development process with a validated quality appraisal tool, such as AIRE (Appraisal of Indicators through Research and Evaluation). While this paper reports on aspects related to the first three AIRE domains (Purpose, relevance and organizational context; Stakeholder involvement; Scientific evidence) [112], further details about the fourth AIRE domain (Additional evidence, formulation, usage) are available in the supplementary material of the results paper of the CareTrack Kids multistage stratified sample medical record review. Our development process did not involve reviewers meeting face to face. The use of online technologies was specifically chosen to enhance transparency, accessibility and timeliness of the development process and minimise "group-think" [69,75]; however it could be argued that an opportunity for reviewers to meet may have stimulated useful discussion on contentious issues [97,113]. While we did encourage experts to make comments (which were included in de-identified format with the next iterations of indicators presented to reviewers in subsequent rounds) in both Stages 3a and 3b, information from the internal review was not able to be conveyed to external reviews (due to project and wiki system constraints).
Based on our experience, and emerging standards around new approaches for evidence development [68], it is recommended that future clinical indicator developers look to further harness available technology such as wikis to help facilitate the rate at which consensus can be achieved, and to optimise its transparency (i.e. ability to capture discussion threads) and reach [11], and include patients within review panels to ensure their perspectives as key stakeholders are captured and considered [114,115]. However, as an interim step and to address the issue of feasibility of measurement and clinical utility of indicators), qualitative research seeking insights from those who develop CPGs, indicators, and medical record software and tools [11,[69][70][71] as well as users (e.g. clinicians, healthcare organisations), could help to bridge the gaps between what we consider to be appropriate care, how it may be relevantly documented, and used to evaluate the quality of clinical practice.

Conclusion
Findings from the modified Delphi approach presented in this study address recommendations for methodological rigor and transparency of reporting [17], and provide an inventory of our experiences and learnings from developing clinical indicators of appropriate care for common paediatric medical conditions. In a critical next step, these clinical indicators will form the criteria against which the CTK study can, for the first time in Australia, measure appropriateness of paediatric care in 2012 and 2013 [64]. Our Delphi approach could be used by others to refine this suite of clinical indicators to local contexts to assist point-of-care decision-making, or providing a starting point for undertaking similar analyses of healthcare practices for benchmarking purposes.
Supporting information S1