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Production and characterization of monoclonal antibodies to Anopheles tessellatus midgut

The production of monoclonal antibodies (Mabs) against antigen derived from the midgut ofAnopheles tessellatus is described. Three cloned Mabs examined were found to be directed against conformational epitopes on midgut antigens. Ingestion of these Mabs in a bloodmeal did not affect mosquito mortality or fecundity. The intake of the Mabs, when compared to normal mouse IgG, with a bloodmeal containingPlasmodium v i v a gametocytes did not reduce the suscept~bility of the mosquito to parasite infection.