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[Histopathological changes of prostate cancer after castration therapy and correlative factors].

OBJECTIVE
To study the histopathological changes of prostate cancer after castration therapy among Chinese and correlative factors.


METHODS
Needle biopsy specimens and prostatectomy specimens were obtained from 17 cases of prostate cancer and examined by light microscopy and image analysis system.


RESULTS
Glandular atrophy, cytoplasmic vacuolization, nuclear pyknosis, and relative increase of stroma could be seen after orchectomy. There was a close correlation between atrophy of neoplastic tissue in prostate gland and patients' age (P < 0.05). The atrophy of neoplastic tissue in prostate gland was not correlated with the serum PSA, tumor staging and grading before castration therapy (P > 0.05).


CONCLUSION
Castration is effective for treatment of prostate cancer, especially among the elderly patients. It is important for pathologists to recognize the histopathological changes in the prostectomy specimens made untypical by castration.