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Abstract 154: The Anti-Neoplastic Effect of Aminosterol Squalamine on Melanoma

PurPose: Squalamine, a recently discovered aminosterol, has notably been shown to be effective as both an antibiotic and an inhibitor of angiogenesis. This intrinsic anti-angiogenic effect of squalamine has been studied in the literature for its clinical capacity to reduce cancer progression. Here, we suggest an additional role of squalamine in inducing melanoma destruction via induction of apoptosis and or necrosis of melanotic cells through angiogenic inhibition.