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Automated diagnosis of Coronary Artery Disease using pattern recognition approach

Coronary Artery Disease (CAD) is the most leading Cardiovascular Disease (CVD), which results due to buildup of plaque inside the coronary arteries. The CAD and Normal Sinus Rhythm (NSR) heartbeats can be discriminated and diagnosed noninvasively using the standard tool Electrocardiogram (ECG). However, manual diagnosis of ECG is tiresome and time consuming task, due to complex nature and unseen nonlinearities of ECG. Hence an automated system plays a substantial role. In this study, CAD and NSR heartbeats are discriminated and diagnosed using Higher-Order Statistics (HOS) cumulants features. Further, the cumulants coefficients dimensionality reduced using Principal Components Analysis (PCA) and the medically significant features (p-value<0.05) Principal Components (PCs) are subjected for classification using Random Forest (RAF) and Rotation Forest (ROF) ensemble classifiers. Proposed system is robust which helps in screening CAD risk factors and telemonitoring applications.