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Articles of Significant Interest Selected from This Issue by the Editors

Honey Bee Virus Structures May Illuminate Entry Mechanism Deformed wing virus (DWV) is a honey bee pathogen linked to colony collapse disorder, which is currently devastating bee populations. Using cryo-electron microscopy (cryo-EM) and particles purified from infectious bee lysate, Organtini et al. (e01795-16) solved the structures of four different capsid conformations: the infectious virus, a naturally occurring empty capsid, a putative entry intermediate that has undergone capsid conformational changes but retains the RNA genome, and an empty capsid that has lost the viral genome. Large protruding spikes decorate the capsids and participate in conformational changes. These capsid changes, which are reminiscent of those of picornaviruses, may occur to facilitate release of the genome during entry.