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Familial liability to intrauterine vascular impairments.

To the Editor.—
 In 1987 in Pediatrics, Stevenson and co-workers discussed the hypothesis that neural tube defects may be produced by inadequate nutrient supply to the rapidly growing neural folds due to primary vascular abnormalities.1 Recently, we found another family which may support this hypothesis (Figure).
 The proposita (Figure, III, 2) was a 5-month-old second-born child of healthy nonconsanguineous parents. The pregnancy and delivery were uneventful. Birth weight was 3630 g (75th percentile), length was 50 cm (50th percentile), and skull circumference 36 cm (75 percentile).