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Evaluation of the Effect of Local Melatonin Gel Application in the Treatment of Intrabony Defects in Chronic Periodontitis Patients:

Background: Melatonin is a free radical scavenger and has antioxidant and anti-inflammatory properties It is also has osteoinductive properties on bone. GCF osteocalcin levels are more revealing than serum or saliva levels regarding bone turnover in periodontium. Aim: The aim of this study was to assess the effectiveness of local drug delivery of Melatonin gel as an adjunct to scaling and root planning in the treatment of moderate chronic periodontitis. Patients and methods: Split mouth design was utilized upon fifteen chronic periodontits patients. Clinical parameters (Gingival Index, Plaque Index, Clinical Attachment Level, probing Pocket Depth) were recorded at baseline and after twelve weeks after treatment. GCF samples were collected at baseline and twelve weeks after treatment. All patients were received scaling and root planning, the test sites only were locally injected with Melatonin gel. Results: The clinical parameters (PI, GI, PD, CAL) showed highly significant improvement in the test sites (SRP+Melatonin) Also the test sites showed statistically high significant reduction in GCF OC than in control sites p<0.001. Conclusion: The local application of melatonin gel offers a promising therapeutic approach in periodontal treatment. Evaluation of the Effect of Local Melatonin Gel Application in the Treatment of Intrabony Defects in Chronic Periodontitis Patients: Mansoura Journal of Dentistry 2019;6(22):15-18. 16 Dina E. AbdAllah Patients and Methods Patient selection: Fifteen patients diagnosed with moderate chronic periodontitis were chosen from the Deparetment of Oral Medicine and Periodontology Clinic, Faculty of Dentistry, Mansoura University. Patients with history of antibiotic administration or periodontal therapy in the last six months or suffering from any relevant systemic disease were excluded from this study.