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Surfactant/antioxidant/ATP therapy after high-dose irradiation of isolated skeletal muscle cells

Ionizing radiation is known to produce lipid peroxidation in cell membranes besides DNA damage. At high irradiation levels this results in a loss of cell membrane integrity followed by acute cell necrosis in the time course of hours. The authors' investigation shows that the membrane sealing surfactant Poloxamer 188 in combination with antioxidants and ATP is effective in improving postirradiation survival.