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Copper Bis(oxazoline)-Catalyzed Enantioselective Alkynylation of Benzopyrylium Ions.

The stereocontrolled construction of biologically relevant chromenones and tetrahydroxanthones has been achieved through the addition of alkynes to benzopyrylium trilfates under the influence of copper bis(oxazoline) catalysis. Excellent levels of enantiocontrol (82-97% ee) are achieved in the addition of a variety of alkynes to an array of chromenones with a hydrogen in the 2-position. Promising levels of enantiocontrol (66% ee) are achieved in the alkynylation of chromenones with esters in the 2-position, generating tetra-substituted stereocenters resembling those frequently found in naturally occurring metabolites.