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Adiponectin in youth: response to Bacha et al.

Bacha et al. (1) studied the relationship of serum adiponectin concentrations with hepatic and peripheral insulin sensitivity, body fat distribution, and components of the metabolic syndrome in adolescents. In addition, they reported a negative association between fasting serum proinsulin and the fasting serum proinsulin-to-insulin ratio with adiponectin levels, which was independent of adiposity. They conclude that hypoadiponectinemia may be a marker of β-cell dysfunction.

These data are novel and appear to be suggestive of a primary role of adiponectin in β-cell function. We consider this hypothesis to …