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Comparison of the effect of thyrotropin and long-acting thyroid stimulator on glucose oxidation and endocytosis in canine thyroid slices.

LATS has a slower onset of action in vivo than does TSH. In the present study, the stimulators were added in vitro to canine thyroid slices, and the time-course of stimulation of glucose- l-14C oxidation and of endocytosis was studied. Dose-response curves for stimulation of glucose oxidation by the 2 stimulators were approximately parallel. When equipotent doses were compared, 1.0 Kriss U/ml of LATS stimulated glucose oxidation with a latency of 9 or 10 min, while 0.2 mU/ml of TSH had a latency of 12.7 or 15 min, in 2 series of experiments. Latency was inversely related to dose and magnitude of response, down to a minimum latency of about 6 min. When stimulation of endocytosis was studied, equipotent doses of TSH and LATS (0.9 mU/ml and 1.0 Kriss U/ml, respectively) shared a latency of 10 min. LATS was always a stronger stimulus to endocytosis, relative to TSH, than to glucose oxidation. LATS, like TSH, stimulated glucose-l-14C oxidation markedly, while stimulating oxidation of glucose-6-14C only slightl...