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Towards a portable laser speckle based device to evaluate the level of atrophy in tissue

In this research we outline the optical background and manufacture of the OPTA device: an Optical Probe to evaluate Tissue Atrophy. We present a portable profiling system capable of directly interrogating the integrity of human skin in vivo. The device utilizes laser speckle and spectral imaging modalities to measure a suite of physical parameters to aid clinical assessment, in particular surface roughness and blood oxygenation. We provide a detailed discussion on the relation between laser speckle scattering and the influence of surface texture. This leads us to discuss how these measurements can relate a participant’s perception of skin pathologies in vivo and discuss the potential clinical application. We will first discuss the technical information relating to the design and assembly of the Optical Probe to evaluate Tissue Atrophy (OPTA) probe, utilizing a biocompatible 3D printing material, polymer optical fibers and custom miniature cage system optics. Finally, we will present the practical use of this device using our results of a pilot study to trial the OPTA device, in house.