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Determinants of reproducibility of lung function tests in children aged 7 to 10 years

Lung function (LF) tests are part of many investigations in childhood lung disease. However, individual reproducibility of LF will confound between‐subject differences. At the same time, increased LF variability has been linked to respiratory disease. In a sample of 598 children, two LF tests, separated by a 5‐min interval, were recorded, and reliability (Rel) of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and maximal expiratory flow at 50% of FVC (MEF50) was determined. Rel was also assessed in children trained and untrained in the performance of LF. To investigate determinants of reproducibility for FEV1, the absolute difference between two repeated tests was calculated. Whenever this difference was >120 ml, a child was considered to demonstrate excessive variability (poor reproducibility) in FEV1.