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103A: ANGIOTENSIN TYPE 1 RECEPTOR BLOCKERS INHIBIT MYOSIN II-DEPENDENT MIGRATION IN KELOID FIBROBLASTS

Introduction: Aberrant fibroblast migration in response to fibrogenic cytokines is believed to play a primary role in the pathophysiology of keloids. Recent evidence has implicated angiotensin II (AngII) as a mediator of cutaneous wound healing and pathologic scarring; however, AngII signaling in keloid fibroblasts remains poorly understood. We investigated the effect of AngII signaling on migration and nonmuscle myosin II (NMMII) expression in keloid fibroblasts as a potential mechanism of disease formation.