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Elevated apolipoprotein B‐48 and remnant‐like particle–cholesterol in heterozygous familial hypercholesterolaemia

Apolipoprotein B‐48 (apoB‐48) is a marker of triglyceride‐rich lipoprotein (TRL) remnants of intestinal origin. Chylomicron remnants are causally related to atherosclerosis. We have shown previously that fasting plasma apoB‐48 may predict postprandial lipaemia. Remnant‐like particle–cholesterol (RLP‐C) may also reflect TRL remnants. We aimed to determine whether subjects with heterozygous familial hypercholesterolaemia (FH) had an accumulation of remnants of intestinal origin, as reflected by fasting plasma apoB‐48 and RLP‐C levels.