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Pro‐inflammatory cytokines in inflammatory bowel disease.

Cytokines playa major role in inflammatory responses in tissues. This includes not only the induction and mediation of inflammation but also the subsequent tissue repair and remodelling that occurs during the healing phase. Pro-inflammatory cytokines are involved predominantly in the induction and perpetuation of inflammation. They include interleukin-l (IL-l). interleukin-6 (IL-6). interleukin-8 (IL-8) and tumour necrosis factor a (TNF-a). A number of studies have investigated the expression of these cytokines in inflammatory bowel disease and some of these are potential targets for therapy.