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Sweet Control: MicroRNA Regulation of the Glycome.

Glycosylation is a sophisticated informational system that controls specific biological functions at both the cellular and organismal level. Dysregulation of glycosylation may underlie some of the most complex and common diseases of the modern era. In the past 5 years, microRNA have come to the forefront as a critical regulators of the glycome. Herein we review the current literature on miRNA regulation of glycosylation and how this work may point to a new way to identify the biological importance of glycosylation enzymes.