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“Cross‐Dressing” Becomes Fashionable Among Transplant Recipients

The current issue features a groundbreaking paper by Smyth, Lechler, and Lombardi entitled “Continuous acquisition of MHC:peptide complexes by recipient cells contributes to the generation of anti-graft CD8 T cell immunity”(1). This paper is now the third of 3 appearing in close succession that are re-defining the allograft rejection paradigm to include a major role for the “semi-direct” pathway(2, 3). A bit of background on the semi-direct pathway is in order. 
 
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