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Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin‐Q

BACKGROUND G protein‐coupled inwardly rectifying potassium (KIR3) channels are important proteins that regulate numerous physiological processes including excitatory responses in the CNS and the control of heart rate. Flavonoids have been shown to have significant health benefits and are a diverse source of compounds for identifying agents with novel mechanisms of action.