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The site of accumulation of 99mTc-sodium pertechnetate in brain tumors.

The site of accumulation of 99mTc-sodium pertechnetate in brain tumors was investigated using autoradiography. Autoradiographs of a mouse glioma showed that radioactivity was present exclusively in the tumor cells, with noevidence ofradioactive material in the small blood vessels orintercellular spaces. Initial human studies have shown a similar accumulation of radioactivityin brain tumor cells. Brain tumors are probably visualized on 99mTc-sodium pertechnetate scans because of the presence of the radioactive material in the braintumorcells.