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[Anti-p53 antibodies as markers of carcinogenesis in exposures to vinyl chloride].

The aim of the study was to estimate the possible use of plasma anti-p53 antibodies as marker premature of cancerogenesis. The study carried on 167 male subject exposed to vinyl chloride (CV) (cumulative concentration ranged from 4 to 2823 ppm) tested anti-p53 positive in 5 cases (3.9%), all distributed in the high exposure group (> 1000 ppm); No subject in the control group tested positive. There was a significant association. between cumulative VC exposure concentration (P < 0.002) and positive anti-p53 expression. In summary, the study support a significant relationship between plasma anti-p53 and VC only for heavy exposure. The authors assume the existence of a threshold limit to the effectiveness.