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DNA Release by Line‐1 (L1) Retrotransposon Could It Be Possible?

Abstract: We have verified the presence of line‐1 retrotransposon (L1) in plasma DNA in 15/17 brain tumor (glioma) patients and in 6/6 healthy people by applying PCR amplification of part of the L1 5′ end. The same samples were separately amplified for K‐ras. Results suggested that L1 sequences are circulating throughout the body. We hypothesized the participation of transposable elements such as L1 in a putative DNA release mechanism.