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INDICATIONS FOR AND FINDINGS AT DUCT EXCISION FOR SINGLE DUCT NIPPLE DISCHARGE

tumours with specific clinical characteristics. Materials and methods: We selected two groups of patients from our archive (PP: poor prognosis vs GP: good prognosis). RNA was extracted from liquid nitrogen-stored tissues and small pools constructed by mixing equal amounts of total RNA from the same number of cases. Pooled RNA from PP and GP tumours were then analysed on cDNA microarrays containing 9,182 probes for known human genes (Incyte Genomics) using the double-fluorochrome Cy3/Cy5 technique. 16 genes were found significantly overexpressed (more than two-fold) in PP versus GP RNA pools. Results: About 20 genes were found overexpressed in GP as compared to PP RNA pools. Among these unbalanced genes, many are correlated with clinical aggressiveness, whereas some are undescribed to date. Further data will be presented about the characterization of these genes pursued on new tumour samples by quantitative real-time fluorogenic RT-PCR and about newRNA tested using oligonucleotide and cDNA microarrays containing new sets of probes. Conclusion: It has been proposed that the gene expression profile will be much more effective than any single marker to identify and classify tumours with specific clinical characteristics.