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Influence of calcium infusion on plasma atrial natriuretic peptide in conscious dogs: intervention with calcium antagonist, verapamil.

In studies in conscious dogs, 1 liter 0.3% calcium chloride infusion resulted in a 163% increase in serum ionized calcium (iCa2+), 166% increase in plasma immunoreactive atrial natriuretic peptide (irANP) and 33% increase in mean blood pressure with significant positive correlation between serum iCa2+ and plasma irANP levels. Pretreatment with verapamil reversed the effects of calcium infusion. These studies have demonstrated that calcium ions play an important role in ANP secretion with reversal by calcium antagonist, verapamil. Hyponatremia seen with calcium infusion could reflect calcium-enhanced sodium excretion. Hypercalcemia was accompanied by non-significant changes in plasma renin activity and significantly elevated serum aldosterone not reversed by verapamil.