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Structural basis of membrane deformation by the ESCRT‐III family of proteins (107.4)

I will report high resolution electron cryo‐microscopy (cryoEM) reconstructions of ESCRT‐III filaments in lipid‐free and membrane‐bound states. These structures reveal that homo‐ and hetero‐dimers are the basic protomers of ESCRT‐III filaments. This unexpected finding illuminates why ESCRT‐III proteins have preferred “pairings” in different biological contexts. For example, mammalian genomes contain ~12 ESCRT‐III proteins and, for example, the protein CHMP2 pairs with CHMP3 during MVB formation whereas IST1 pairs with CHMP1 during cell division. Incorporation of different subunits may alter the architecture of the ESCRT‐III lattice to change its curvature, rigidity or propensity to bundle for different processes. These and related models will be discussed in the context of new structural models.