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Treatment of severe coagulopathy in the Kasabach-Merritt syndrome with aminocaproic acid and cryoprecipitate.

The Kasabach-Merritt syndrome is characterized by thrombocytopenia associated with solitary or multiple hemangiomas.1 Coagulation studies in patients with this disease frequently reveal a profile similar to that of disseminated intravascular coagulation.2 , 3 The disorder is of particular clinical interest since complete eradication of the tumor by surgical excision or radiation eliminates the coagulopathy.4 , 5 Although the syndrome is primarily a disease of infancy, some patients survive for long periods, particularly if the coagulation defect is mild. In the absence of treatment, fatal hemorrhage can result.4 5 6 The syndrome is unique in that the coagulopathy is believed to be a manifestation of clotting and . . .