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Oral Prostaglandin E2 for Induction of Labor at Term

The efficacy of orally-administered prostaglandin E2 for induction of labor was studied in 45 normal gravidas at term, using three dosage regimens. Comparisons were made to a series of patients with unstimulated labors and others with oxytocin-induced labors who were matched with study patients according to pre-labor cervical preparation and other relevant features. All labors were analyzed according to patterns of cervical dilatation and station versus time. Oral prostaglandin E2 was found capable of inducing labor in 86.7% of patients. The labors that resulted were quantitatively between the spontaneous labor and oxytocin-induced labor patterns, in an apparent dose-response relationship. Side effects were also dose related, occurring most frequently and with greatest severity in the highest dosage program. Hypercontractility was also encountered; its significance deserves close scrutiny. For purposes of clinical usage it will be necessary to strike a balance between dosage levels that are effective therapeutically but will yield only negligible or minimally acceptable side effects.