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Diffuse Large B-Cell Non-Hodgkin Lymphoma Mimicking Stroke: A Case Report

About 1 in every 4 cases of stroke is probably a stroke mimic. There are rare etiologies mimicking a stroke such as cerebral vasculitis, coagulopathies, and lymphoma. The occlusion of small cerebral vessels by malignant intravascular lymphoma was first described in 1959 as “angioendotheliomatosis proliferans systemisata.”1 Since then, there are case reports of stroke mimic by diffuse large B-cell non-Hodgkin lymphoma (DLBCL), intravascular large B-cell lymphoma (IVLBCL), and angioimmunoblastic T-cell lymphoma. The timely diagnosis and use of adjuvant chemotherapy in patients of DLBCL with central nervous system (CNS) involvement is necessary to preclude a dismal prognosis.