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The New Zeiss GeminiSEM 500 Meets the Needs of Challenging Biological Applications

Modern field emission scanning electron microscopy (FE-SEM) techniques are increasingly important for studying structural properties of cells and tissue. Typical applications include imaging of tissue by serial block face or array tomography methods (AT) [1,2]. In serial block face imaging a thin layer of the embedded sample is removed either mechanically or with a focused ion beam. Afterwards the fresh block face is imaged. In contrast for AT serial sections of the sample are produced in advance and mounted on a solid support (i.e. silicon wafer, glass). The individual sections are investigated in the FESEM afterwards. The imaging modes can vary from secondary electrons (SE) over back scattered electrons (BSE) detection to scanning transmission electron microscopy (STEM). Key performance parameters for biological imaging are optimum resolution and contrast, surface sensitivity, control of sample charging as well as the need of speeding up the data acquisition for high-throughput imaging.