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INTENSITY OF IMMUNITY TO MEASLES, TETANUS AND DIPHTHERIA AMONG THE POPULATION OF DNIPRO CITY

It is known that such infectious diseases as measles, diphtheria and tetanus pose a significant threat to people, regardless of their age group. These infections, unfortunately, are quite common even now and require constant epidemiological surveillance to avoid outbreaks. This can be achieved through vaccination, if the timing of its application, established by the calendar plan, is followed. The aim of the research was to conduct an analysis of the intensity of immunity to measles, tetanus, and diphtheria based on the results of surveys of humoral immunity indicators of the population of Dnipro city. To solve the tasks of research, we used the data analysis of the results of the study of biological material (blood serum) from people aged 0 to 58 years, who want to get results to make a decision about the need for vaccination against diphtheria, tetanus and measles and with suspicion of these infections. A total of 485 samples were examined. The study of antitoxic immunity was carried out by determining the titers of IgG / IgM antibodies against diphtheria and tetanus toxins, as well as against measles antigens. The level of anti-measles, anti-diphtheria and anti-tetanus immunity was assessed in accordance with the recommendations of the World Health Organization (WHO). As a result of the analysis, it was found that the group of people 48 years and older, whose level of antibodies indicates a decrease in immunity with increasing age and insufficient vaccination coverage of this age group, is the largest risk group for diphtheria, tetanus and measles. In general, there is a reduced population immunity to diphtheria, measles and tetanus, which indicates the need to expand vaccination among the population to prevent epidemic outbreaks. The obtained data confirm that vaccination of children, according to the calendar of preventive vaccinations and revaccination of adults (every 10 years) can become a powerful tool for the prevention of infectious diseases under conditions of mass vaccination.