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Delivery of the photodynamic agent under the nail plate using Er-laser microperforation and laser-induced hydrodynamic processes

The active delivery of photodynamic agent (aqueous solution of methylene blue) under a nail plate is discussed. The delivery was implemented by microperforating the nail plate using Er:YLF laser radiation and stimulating hydrodynamic processes in drug droplet on the nail surface under the action of Yb,Er:Glass laser pulses. Optimal pulse energy of Yb,Er:Glass laser radiation for effective active delivery of the photodynamic agent is determined.