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Antidiabetic Effects of the Auricularia auricular Polysaccharides Simulated Hydrolysates in Experimental Type-2 Diabetic Rats

A model of type-2 diabetes mellitus (T2DM) using high-fat diet and low-dose STZ was established to assess the antidiabetic effects of Auricularia auricular polysaccharides simulated hydrolysates (AAPHs) obtained from the dried fruiting body of A. auricular. AAPHs were administered intragastrically (i.g.) at the dose of 0.15 g/kg b. W. to diabetic Wistar rats for 4 weeks. Results show that AAPHs was demonstrated to exhibit significant diminution in T-CHO and LDL-C levels (P < 0.05 or P < 0.01) compared to the diabetic control group. In addition, the secretion level of GLP-1 were different with the diabetes model group from 0 to 30 min, and had a tendency to alleviate weight loss. The current study suggests that AAPHs might be incorporated as a supplement in diabetic agents or combined with other health-care foods.