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Uptake and Dispersion of Metformin in the Isolated Perfused Rat Liver

Although metformin is a widely used oral antihyperglycaemic, the exact mechanisms of its cellular uptake and action remain obscure. In this study the hepatic extraction and disposition kinetics of metformin were investigated by use of an isolated in‐situ rat liver preparation. The liver was perfused in single‐pass mode with protein‐free Krebs bicarbonate medium at a flow rate of 20mLmin−1.