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Significance of p16 protein expression in gastric cancers

AIM To detect the expression and distribution ofp16 protein in pericancerous tissue and gastric carcinoma tissues. To analyze the relationship between p16 protein expression and clinical pathological characterizations, prognostic factors of gastric carcinoma. METHODS Expression of p16 protein was observed in carcinoma tissue of 53 cases of gastric cancer and pericancerous tissue of 35 cases of gastric cancers by S P immunohistochemistry. RESULTS Expression of p16 protein was observed in gastric carcinoma tissues and pericancerous tissues. Positive rate of p16 was 62.3% and 88.6% respectively. The positive brown granules were mainly distributed in the nucleus. p16 protein expression was not related to age, sex and tumor position, but was significantly correlated with histological type, invasion depth, lymph node metastasis and clinical pathological stage. The 5 year survival rate of p16 positive patients was higher (51.0%) than those of p16 negative patients (20.0%, P 0.05). CONCLUSION Loss of p16 gene and change of expression level are correlated with gastric cancer and p16 protein can be used to evaluate the biological behavior and prognosis of gastric cancer.