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A Search for the Ideal Fixative.

Formalin has proved a remarkably useful fixative for tissue specimens, and that is the reason why it remains the best choice for routine work after a century. Yet, it is difficult to believe that it cannot be improved by matching its notable capacity for retaining tissue and cell architecture while also achieving a better preservation of DNA, RNA, and proteins for molecular work. The National Cancer Institute is challenging investigators to attempt this feat, and pathologists should be participating in the effort.