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“I‐J” as an Idiotypic Marker on the Antigen‐Specific Suppressor T Cell Factor

The I-J subregion was originally mapped between the I-A and I-E subregions of the mouse H-2 complex (MHC), and is defined by H-2-congemc pairs, such as BI0.A(3R) and B10.A(5R), or BI0.S(9R) and BIO.HTT (Murphy et al. 1976). In particular, B10.A(5R) and B10.A(3R) are derived from a cross between A/WySn and C57BL/10 and were thought to represent identical recombinational events, since none of the known properties of the MHC genes seemed to distinguish two congenic hnes (Stimpfling & Reichert 1970). However, a genetic difference between B10.A(3R) and B10.A(5R) was demonstrated by Murphy et al. (1976) in their ability to absorb antibody activity to allotype-specific suppressor T cells from conventional alloanti-Ia'' antiserum (A.TH anti-A.TL). Therefore, the recombination points of these H-2-congenic strains seem to be diiferent, defining a new subregion encompassing the Ia-4 locus coded for the product on suppressor T cells. However, recent molecular genetic studies, especially on tbe molecular map of the I region as reported by Steinmetz et al. (1982), have clearly demonstrated that there is little or no room to accomodate a gene encoding an I-J molecule in the expected I region between the I-A and I-E subregions. In other words, there seems to be no evidence for a distinct I-J gene between the E-alpha and E-beta genes that encode the alpha and beta chaias of the I-E molecule, and these two genes also define the boundaries of the I-A and I-E subregions in the classical genetic mapping grid. Moreover, Kronenberg et al. (1983) have analyzed the expression of I-J-related sequences by examining RNA transcripts from suppressor T cell hybridomas. An attempt was made to hybridize mRNAs prepared from several suppressor T