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[Verification of the validity of the Giacovazzo skin test with histamine at neutral pH].

In this study the different activities of histamine chloride and histamine phosphate have been tested in the cutaneous test as Giacovazzo in patients with Cluster Headache. The Authors executed the test in 20 C.H. patients and in 20 control subjects, using histamine chloride and phosphate. In order to evaluate the results, three parameters were taken into consideration: Latency Time, Hyperemia Diameter and Extinction Time. A statistical (non orthogonal) comparison of data obtained, showed no difference within the groups, while it showed the significant difference (p less than 0.001) between the groups. There was no difference between the activity of histamine chloride and phosphate in the "histamine skin test" as Giacovazzo.