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Anti tumour efficacy of curcumin/chitosan-coated iron oxide nanoparticles in human lung cell line (L132) In an In Vitro study

Cancer may be a major public ill health, with significant associated death and disability. It is the second leading explanation for death in developed countries and is one among the three leading causes of death for adults in developing countries. Cancer which causes the morbidity and mortality in worldwide, approximately 14 million new cases in 2012.The number of latest cases is predicted to rise by about 70% over the next 2 decades. The present work was aimed to investigate the effect of curcumin/chitosan-coated iron oxide nanoparticles for topical application on L132 cells, for example, cytotoxicity, Reactive oxygen species (ROS) and induction of apoptosis. Diseases resulting from dermal exposure may have a big impact on human health. Cytotoxic potential of curcumin/chitosan-coated iron oxide nanoparticles was measured by tetrazolium bromide (MTT assay) in L132 cells. ROS assay and cell cycle were used to confirm the basis of apoptosis. Apoptosis was investigated by Annexin V with the Propidium iodide method in Flow cytometryanalysis.