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Doped Halloysite Sutures for Clinical Medicine

In the ER, wounds are the third most common injuries treated with sutures that stop the bleeding and close the wound. Subsequent wound management is mainly treatment for postoperative infections. A suture providing sustained release of antibiotics/antiseptics directly into the wound site is highly desired. Halloysite is a biocompatible clay nanotube. It is a double‐layered aluminosilicate, structurally similar to kaolin, with a diameter of 10–50 nm. Halloysite was loaded with antiseptics and antibiotics and mixed with poly‐e‐caprolactone and using the electrospinning technique was spun into various fibrous materials including sutures, gauze and wound dressings. These materials were added to confluent bacterial cultures of S. aureus and E. coli and maintained (via serial culture) over a two‐month experimental period. Control cultures consisted of halloysite/PCL fibrous materials minus antibacterials. Doped halloysite/PCL materials created and maintained a zone of growth inhibition over the two‐month period. Control cultures failed to inhibit bacterial growth. Results suggest that postsurgical infections could be controlled, reducing patient cost, promoting quick recovery, and return to normal health.