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Studies on the Mechanism of Fat-Free Diet (FFD) Protection Against Indomethacin-Induced Intestinal Ulcers

Summary The possible relationship between bile flow and/or composition as well as β glucuronidase activity of the intestinal content and indomethacin-induced intestinal lesions has been investigated. In general, the following conclusions can be drawn: (i) The lower incidence of intestinal lesions in fat free (FFD) as compared to regular (RD) diet rats, must be attributed to factor(s) other than reduction in bile flow and/or composition. (ii) Intestinal β glucuronidase activity is markedly reduced in indomethacin-treated FFD and D-glucaro 1,4 lactone medicated RD rats. (iii) In agreement with data in the literature, our results indicate that there is a relationship between the decrease in intestinal β glucuronidase activity and the reduction in intestinal lesions. These findings are discussed.