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Lipoprotein composition in the alloxan-diabetic rabbit.

This study investigates the lipoprotein abnormalities in the alloxan-diabetic rabbit maintained on a standard chow diet. Poorly-controlled diabetic rabbits had elevated levels of triglyceride and phospholipid (reflected in all lipoprotein fractions) and cholesterol (reflected in the very low density and high density lipoprotein fractions) compared with well-controlled and non-diabetic rabbits. The importance of diabetic control in these changes was emphasized by the observation of a positive correlation between weight loss and serum triglyceride (rs = 0.62, p less than 0.02), cholesterol (rs = 0.65, p less than 0.01) and phospholipid (rs = 0.56, p less than 0.05). The lipoprotein fractions of the poorly-controlled rabbits were enriched with triglyceride.