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Effective combination treatment of advanced acute lymphocytic leukemia with cytosine arabinoside (NSC-63878) and L-asparaginase (NSC-109229).

The combination of cytosine arabinoside and L-asparaginase induced remission in 15 of 22 children (68%) with previously treated acute lymphocytic leukemia (ALL). Eight of these patients were in remission after the second week of treatment and seven were in remission after the fourth week. The combination was well tolerated. These preliminary results suggest that these two agents have an additive therapeutic effect in inducing remissions in children with advanced ALL.