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BioGAT : a Grid Toolkit for Bioinformatics Sequence Alignment

Even though there are many useful tools for sequence alignment such as Blast by NCBI, Fasta by the University of Virginia and Smith-Waterman, by NIST, one of the key issues is that sequence databases are exploding in size, growing at an exponential rate. Grid and parallel computing are crucial techniques to maintain and improve the effectiveness of sequence comparison tools, whereas the Web Services approach may guarantee the interoperability among large collections of programs and data. This work describes BioGAT (Bioinformatics Grid Alignment Tools), a toolkit that offers optimized brokering and a data management system to exploit various bioinformatics alignment tools wrapped as Web Services in a Grid architecture.