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Does Aging Adversely Affect Muscle Mitochondrial Function?

SHORT, K.R., and K.S. NAIR. Does aging adversely affect muscle mitochondrial function? Exerc. Sport Sci. Rev., Vol. 29, No. 3, pp 118–123, 2001. Muscle oxidative function appears to decline with aging, and evidence suggests that this is related to reduced synthesis of mitochondrial and other muscle proteins. Causes for these events may include mtDNA damage or reduced mtDNA copy numbers, reduced oxidative enzyme activities and ATP production, and increased proton leak.