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The effect of cholinesterase inhibitors on SFEMG in myasthenia gravis

We report four patients with myasthenia gravis (MG) in whom single‐fiber electromyography (SFEMG) jitter measurements were normal in some muscles while they were taking pyridostigmine and became abnormal 2–14 days after the medication was discontinued. When the abnormality of neuromuscular transmission in MG is mild, cholinesterase inhibitors may mask the findings of increased jitter on SFEMG.