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Inflammation in Irritable Bowel Syndrome: Curiosity or Culprit

There has been a recent surge in interest in mucosal immune activation as a potential mechanism for IBS symptom generation. However, despite the identification of subsets of patients meeting current symptom criteria for IBS who show evidence for immune activation on mucosal biopsies, it is hypothesized that alterations in the central processing of visceral afferent information are necessary for characteristic irritable bowel syndrome (IBS) symptoms to develop.