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[Autoregulation of the gonadotropin receptors in rat testes after human chorionic gonadotropin administration (author's transl)].

Occupancy of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptors in testes by LH or hCG is followed by stimulation of 3':5'-cyclic AMP (cAMP) production and testosterone synthesis. However, recently a sustained loss of testicular LH/hCG receptors after systemic administration of LH or hCG has been observed. Therefore we studied the functional relations between negative regulation of LH/hCG receptors and desensitization of cAMP and steroidogenic responses in the testes of rats treated with exogenous gonadotropin. Adult male rats (200-250gr) were orchiectomized everyday for a week after an intra-