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Alterations in vascular reactivity in a transgenic mouse model of sickle cell trait

Additional supporting information may be found online in the Supporting Information section at the end of the article. Data S1. Supplemental data. Fig S1. Supercoiled and linear spike-in control: MRD estimation comparison. Fig S2. Read fraction and qPCR versus NGS mean absolute error per spike-in subset. Fig S3. Frequency of spike-in reads by total VDJ reads. Fig S4. Spike-in controls amplification per VH family. Fig S5. Universal versus Family/Universal fitting comparison. Fig S6. Accuracy of NGS MRD is not influenced by spikein read fraction. Fig S7. D0 and D35 leukaemia clones for notable cases. Fig S8. Comparison of MRD values for samples analysed both in the pilot and main studies. Fig S9. Copy number-based subsets of spike-in control produce similar NGS MRD values. Table SI. Sequences of the complete IGH rearrangements used as spike-in control. Table SII. BIOMED-2-based FR2 primers with non-complementary 5ʹ overhangs for complete IGH rearrangements amplification and NGS library construction. Table SIII. Paired qPCR and NGS MRD values for 129 leukaemia markers. Table SIV. Mean Absolute Errors of NGS MRD calculated by Universal or Family/Universal fitting against qPCR MRD. Table SV. qPCR+/NGS MRD patients results. Table SVI. qPCR /NGS+ MRD patients results.