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Improving the quality of endoscopic surveillance of patients with lynch syndrome.

SS Lynch syndrome, an autosomal-dominant condition caused by germline mutations in one of the DNA mismatch repair genes, accounts for approximately 5% of all colorectal cancers (CRCs). Depending on the type of mutation, CRC will develop in 40–80% of patients with Lynch syndrome during their lifetime. In patients with Lynch syndrome, CRC is diagnosed at a relatively young age compared with sporadic CRC. Of particular importance, nearly 70% of the CRCs diagnosed in patients with Lynch syndrome are located in the proximal part of the colon, where colonoscopy has shown limited effectiveness for preventing CRC. For these reasons, high-quality endoscopic surveillance is vital in patients with Lynch syndrome.