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Mode of inheritance of Perthes' disease in Manchester terriers.

A test mating between two Manchester Terriers affected by Perthes' disease (PD) resulted in the birth of three affected males and two unaffected females. In the three puppies with PD, roentgenographically detectable changes in the affected femurs were observed two to three weeks before the onset of lameness and muscle atrophy in the corresponding limb. Analysis of the related pedigrees and of the results of the test mating indicated that PD is an inherited condition with high heritability.