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EFFICACY OF SINGLE DOSE VERSUS MULTIPLE DOSE ANTIBIOTIC PROPHYLAXIS IN CLEAN AND CLEAN-CONTAMINATED HERNIORRHAPHY SURGERY

BACKGROUND Our study is aimed to compare the impact of single vs. multiple dose of antibiotic in clean and clean contaminated herniorrhaphy in terms of post-operative infection related complications. The present study was prospective and longitudinal. Protocol of the procedure was formed along with Performa, Patient Information Sheet and Informed Consent Form. This study was carried out from August 2016 to August 2017 in surgery department in association with Gen. Medicine Department of Mahatma Gandhi Medical College & Hospital, Jaipur. Total 160 patients who were admitted for elective herniorrhaphy were included in our study. The patients were randomly divided in two equal groups: single dose (SD) group and multiple dose (MD) group, comprising of 80 patients in each group. SD group was given Amoxycillin-Clavulanic acid (2 gm) intravenously at the time of induction of anaesthesia. Whereas, MD group was given Amoxycillin-Clavulanic acid (2 gm) intravenously at the time of induction of anaesthesia followed by Amoxycillin-Clavulanic acid (1 gm) intravenously twice a day for two days post-operatively. In single dose antibiotic group, total post-operative infection rate was 8% and that in multiple dose groups was found to be 0%. Data was analysed with Chi- square test and the difference in the rate of SSI in both the groups was found statistically insignificant. CONCLUSION The rate of post-operative SSI after single dose antibiotic intravenously at induction of anaesthesia is comparable with that of multiple dose antibiotics. So single dose antibiotic regimen can be safely practiced in Herniorrhaphy.