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Positive association of up‐regulated Cripto‐1 and down‐regulated E‐cadherin with tumour progression and poor prognosis in gastric cancer

Aims:  Cripto‐1 may be capable of up‐regulating signalling molecules associated with epithelial‐to‐mesenchymal transition (EMT), an important event characterized by loss of E‐cadherin during malignant tumour progression and metastasis. The aim was to investigate the expression of Cripto‐1 and E‐cadherin in relation to clinicopathological features and patient prognosis of gastric cancer.