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Compression of the optic chiasm is associated with permanent shorter sleep duration in patients with pituitary insufficiency

Objective  Patients with pituitary insufficiency often experience some degree of impaired sleep. Sleep–wake rhythm is regulated to a large extent by the suprachiasmatic nucleus (SCN). Because the SCN is located just superior to the optic chiasm, we hypothesized that a history of compression of the optic chiasm (CC) due to a tumour with suprasellar extension is associated with altered sleep patterns in patients with pituitary insufficiency.