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Self-poisoning with prazosin.

A 75-year-old man ingested 80 mg prazosin 3 hours before admission to hospital. On admission, plasma prazosin level was 2350 nmol/l—more than 20 times the maximum level after a therapeutic single dose of 5 mg. Supportive treatment was given and the patient made an excellent recovery. This case indicates that prazosin is a drug with low acute toxicity.