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Evaluation and management of insomnia, muscle cramps, fatigue, and itching in cirrhotic patients

Cirrhosis is associated with overt and proximately causal complications such as ascites, hepatic encephalopathy, and esophageal varices for which management is well defined and broadly implemented. However, there remain many symptoms whose etiology, morbidity, and treatment continue to be poorly understood. This concise review discusses the symptoms of (1) insomnia, (2) muscle cramps, (3) fatigue, and (4) itching.