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[Reparative processes in the rat stomach in long-term nonhealing experimental ulcers].

Gastric ulcer in rats was induced by exposure to acetic acid according to the method of Okabe. The reparative processes in the ulcerative defect zone of gastric mucosa, in adjacent and distant fundic glands were studied by the quantitative methods (determination of the cellular composition of the glands, of the diurnal number of DNA-synthetising cells, mitoses). It was established that on the 15th day after induction of the ulcer, the level of proliforation in the zone was significantly increased as compared to that in intact controls, while in distant areas it remained unchanged. By the 40th day the regeneration was effected by greater enhancement of DNA synthesis and cell division. By this time the number of regenerated glands as well as the number of constituent cells had also increased. Similar changes in the glands of the resected stomach were seen near the anastomosis over a period of 180 days after the operation.