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Characterization of the natural immune response of rhesus monkey CD4+ve T cells to the bacterial antigen streptolysin O (SLO)

Abstract: Rhesus monkeys show a high proliferative T cell response to the bacterial exotoxin SLO without prior immunization. The present study was undertaken to characterize this naturally present SLO‐responsiveness with particular emphasis on CD4+ve reactive T cells. It is demonstrated that the frequency of SLO‐reactive cells in the circulation ranges between 1 in 75 and 1 in 610 CD4+ve T cells as determined with limiting dilution analysis. It is also shown that induction of a good proliferative response requires Mhc‐DR matching between T cell and the antigen presenting cells (APC). Stable and DR‐restricted SLO‐specific CD4+ve T cell lines were generated from CD8 depleted peripheral blood mononuclear cells (PBMC). The SLO‐reactive CD4+ve cell lines are tentatively characterized as Thl‐like based on the predominant production of interferon‐gamma (IFN‐γ) over IL‐4, although this seems contradicted by the IL‐4 dependent growth of the lines.