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[Evaluation of red cell mean corpuscular volume and simple tube red cell osmotic fragility quantitative test in detection of thalassemia].

OBJECTIVE
To evaluate and compare the detection efficiency of red cell mean corpuscular volume(MCV) test against simple tube red cell osmotic fragility quantitative test(STROFQT) in diagnosis of thalassemia.


METHODS
1978 subjects (989 couples) were detected by both MCV test and STROFQT, 158 samples from subjects were tested by alpha,beta-thalassemia DNA polymerase chain reaction(PCR) and serum ferritin test.


RESULTS
The positive rate (9.0%), sensitivity (98.9%) of MCV test were higher than those of STROFQT (8.1%, 88.6%) (P < 0.05). The specificity of MCV test showed no statistic significance compared with that of STROFQT (P > 0.05).


CONCLUSION
Both MCV test and STROFQT served as helpful approaches in detection of thalassemia, MCV test shows better diagnostic efficiency for screening than STROFQT.