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Lactate down‐regulates cellular poly(ADP‐ribose) formation in cultured human skin fibroblasts

Background  Polyadenosine diphosphate‐ribose (poly(ADP‐ribose)) is a nuclear polymer which is derived from nicotinamide adenine dinucleotide (NAD+) catalysed by poly(ADP‐ribose) polymerase 1 (PARP‐1). Aside from the well known role of poly(ADP‐ribosyl)ation (pADPR) in DNA repair, pADPR is also involved in other cellular processes such as apoptosis and gene expression. However, the factors that regulate the level of pADPR are not fully elucidated. In view of the fact that healing wounds contain high concentrations of lactate (10–15 mm) and exogenous lactate reduce the NAD+ pool in cultured fibroblasts, we propose that high lactate lowers the level of nuclear pADPR.