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Abstract TP117: Endothelial Progenitor Cells in Acute Stage of Ischemic and Hemorrhagic Stroke


 Introduction:
 Endothelial progenitor cells (EPC) play an important role in the regeneration of the nervous tissue, blood-brain barrier stabilization and in neovascularization of blood vessels damaged by stroke. The aim of the study was to assess the level of EPC in patients with acute cerebral stroke due to cerebral microangiopathy and the potential dependence with the clinical condition, radiological image and prognosis, both in the ischemic and the haemorrhagic stroke.
 
 
 Methods:
 66 patients with lacunar ischemic stroke were included in the prospective study, 38 patients with the “loco typico” haemorrhagic stroke and 22 from the control group without acute/chronic cerebral circulatory disorders. The level of EPC was determined using flow cytometry and identified with the immune-phenotype CD45–, CD34+, CD133+ on the 1
 st
 and 8
 th
 day of stroke.
 
 
 Results:
 It has been shown a significantly higher level of EPC on the 1
 st
 day of stroke (regardless of aetiology) compared to the control group (med. 17,75 cells/ul (0-488 cells/ul) vs 5,24 cells/ul (0-95 cells/ul); p=0.0006). The level of EPC on day 1 and 8 was correlated with the subgroup of patients with haemorrhagic stroke. A significant correlation was found between the volume of the haemorrhagic focus on the 1
 st
 day and the level of EPC (R= -0.3378, p=0.0471) and the degree of regression of the haemorrhagic focus and the level of EPC (R=-0.3896, p=0.0367).
 
 
 Conclusions:
 The study showed that endothelial progenitor cells are an early marker of cerebral vascular damage, both in ischemic and haemorrhagic stroke. The research highlights, for the first time, the relationship between the level of EPC and the degree of regression of a haemorrhagic focus. However the prognostic value of EPC for clinical condition and prognosis of stroke patients was not found in the study.
 
 
 
