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Significance of G-protein Coupled Receptor Kinase 2 in Heart Failure

Incidences of heart failure represent an epidemic of cardiovascular disease in the 21st century.Recent research has indicated that clinical analysis is insufficiently accurate for the diagnosis of heart failure,and sensitive and specific biomarkers should be found to assist the diagnosis.GRK2,also known as the β-adrenergic receptor kinase 1(β-ARK1),a G-protein coupled receptor kinase(GRK).The occurrence of GRK2 in heart is rather specific,and its levels and activity are closely associated to cardiac function.There is evidence that GRK2 may be a valuable biomarker which can be used in the diagnosis of heart failure and to judge the severity of the disease,which will govern the juncture and level of clinical intervention.This article is a brief review of the significance of GRK2 in heart failure.