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Activity of phenacetin O-deethylase in rat liver: effect of inducers and inhibitors in vivo.

A method for the determination of microsomal phenacetin O-deethylase activity in the rat liver was described. Optimum conditions in which phenacetin is enzymatically converted to N-acetyl-p-aminophenol were determined. The product of enzymatic reaction was acid-hydrolyzed while heating. The amount of p-aminophenol formed was determined by means of indophenol reaction. The described method was applied to assess activity of phenacetin O-deethylase in normal rats and rats treated with inducers or inhibitors of microsomal monooxygenases, phenobarbital, 3,4-benzpyrene, SKF 525-A and cobaltous chloride, respectively.