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Splenic Macrophage Interaction with Red Cells in Pyruvate Kinase Deficiency and Hereditary Spherocytosis 1

Little is known in man about the in viuo interaction between circulating erythrocytes and the reticuloendothelial system. We have previously reported our observations principally in formalin-fixed tissues on the histiocytic activity between splenic macrophages and a metabolically aberrant cell the pyruvate kinase deficient erythrocyte [2]. I n this report, employing a different technique, we contrast the spleen-red cell interaction in this disorder with that in hereditary spherocytosis, a more common intrinsic red cell disorder in which initially ATP formation is stimulated, rather than depressed. Conceivably, the extra vascular red cell demise characteristic of these diseases may occur [4, 6, 11, 121 in other circumstances, including transfused red blood cells exposed to varied modes of cell preservation.