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[Role of the neurosecretion of the supraoptic and paraventricular hypothalamic nuclei in the pathogenesis of experimental urolithiasis].

Experiments made on male rats fed oxamide during 10 days provided new data on the changes in the morphofunctional status of the hypothalamo-hypophyseal neurosecretory system (HHNS) in the course of the development of urolithiasis. The changes develop in three stages. The first stage is marked by an increase of the HHNS functional activity, the second one by its decrease, and the third one by its recovery. It is concluded that the changes in the secretion of antidiuretic hormone produced by supraoptic and paraventricular nuclei of the hypothalamus are involved in the pathogenesis of urolithiasis, which should be taken into account in multiple modality treatment of the disease.