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A "Three-in-One" SERS Adhesive Tape for Rapid Sampling, Release and Detection of Wound Infectious Pathogens.

The traditional colony culture method for detection of pathogens is subjected to the laborious and tedious experimental procedure, which limits its application in point-of-care testing and quick diagnosis. This work designs an intelligent adhesive tape as a "three-in-one" platform for rapid sampling, photo-controlled release and SERS detection of pathogens from infected wound. This tape is constructed by encapsulating densely packed gold nanostars as SERS substrate between two pieces of graphene, and modified with synthetic o-nitrobenzyl derivative molecule to form an artificial biointerface for highly efficient pathogen capture via electrostatic interaction. The captured targets can be conveniently released onto solid culture medium by UV cleavage of o-nitrobenzyl moiety for pathogen growth and in situ SERS detection. As a proof-of-strategy, this "three-in-one" platform has been used for detecting the concurrent infection of Pseudomonas aeruginosa and Staphylococcus aureus by pasting the tape on skin burn wound. The impressive detection performance with an analytical time of only several hours for these pathogens at early growth stage demonstrates its great potential as a point-of-care testing device for healthcare.