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Allergic contact dermatitis to zinc pyrithione

Zinc pyrithione (zinc 2-pyridinethio1-1-oxide, zinc pyridinethione) is an off-white powder used as an anti-dandruff agent in many shampoos (1), hair creams, and cosmetics. It is an effective substance to control seborrhoeic dermatitis (2, 3). Its mode of action is unknown, but studies showed that it may have an anti-mitotic effect ( 4) or some non-specific toxicity (5) on epidermal cells. It is also used as a preservative in cutting oils (6). Despite widespread use, there have been few reports of allergic contact dermatitis from it (7-9). We report a patient who developed allergic contact dermatitis to zinc pyrithione in a shampoo and a hair cream.