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Effects of anesthesia and sleep on circulatory response to carotid sinus nerve stimulation.

VATNER, STEPHEN F., DEAN FRANKLIN, AND EUGENE BRAUNWALD. Effects of anesthesia and sleep on circulatory response to carotid sinus nerve stimulation. Am. J. Physiol. 220(5) : 12491255. 197 l.The effects of electrical stimulation of the carotid sinus nerves on arterial pressure, heart rate, and peripheral blood flows were studied in healthy dogs while conscious, asleep, after general anesthesia with Na pentobarbital, and after autonomic blockade. In the resting conscious dog, 30-set periods of carotid sinus nerve stimulation resulted in average decreases in heart rate of 12 %, arterial pressure 27 %, coronary flow 5 %, mesenteric flow 9 %, and renal flow 8 %, while iliac flow increased by 112 %. In sleeping dogs, the decrease in heart rate (22 %) was greater than when awake. In anesthetized dogs, the decreases in resistance in all beds with stimulation were not as great as in conscious dogs and the periods necessary for arterial pressure and heart rate to return to control following stimulation were prolonged. The bradycardia was mediated predominantly by the vagus nerves in conscious dogs and by the sympathetic nerves in anesthetized dogs. Thus, when compared to conscious dogs, baroreceptor stimulation in anesthetized dogs resulted in less peripheral vasodilatation, slower recovery of arterial pressure and heart rate, and a different pattern of autonomic control of heart rate.