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Leisure-time Running And All-cause Cancer Mortality: 1874 Board #26 June 2, 3: 30 PM - 5: 00 PM.

METHODS:This small pilot study recruited advanced stage cancer patients (n=3) with dyspnoea from the Derby Royal Hospital (UK), who consented to an incremental IMT programme of 9 weeks (Powerbreath classic light). Patients were given advice on breathlessness management strategies and asked to record self-set goal achievement in a diary. Functional measurements taken at baseline, and then 3 and 9 weeks post IMT included a 6 minute walk test (6MWT), spirometry and maximal inspiratory mouth pressure (MIP). Ratings of perceived exertion (Borg 6-20 scale) and modified dyspnoea score (1-10) were recorded for the 6MWT. Additionally, participants completed a St. Georges Respiratory Questionnaire (SGRQ) at all time points and contributed to a focus group at the end of the study. RESULTS:We found that participants showed a significant functional improvement after 9 weeks of IMT as measured by the 6MWT; although the distance travelled did not change pre 282m +/-141; Post 350m +/127 (P >0.05), the dyspnoea (pre 4.0+/-1.0; post 2.0+/-1.0) and perceived exertion (pre12+/-3.0; post 9.0+/-2.0) for each participant during the 6MWT was significantly reduced (P <0.05) at end of test. MIP increased in two of the participants (40% and 50%), but remained unchanged in the third participant, who had a higher than predicted baseline (MIP pre 87+/26 cmH2O; post 108 +/10 cmH2O). During the focus group all participants asserted that this technique had helped them in their daily life and was easy to fit into their schedules. No significant results were found with the SGRQ or with the goal-setting diary. CONCLUSIONS: IMT is a well-tolerated intervention for advanced cancer patients suffering from dyspnoea however a larger trail is needed and currently being planned.