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[Membranotoxicity of tumor cells to lymphocytes. Role of homology for IC-subregion of H2-complex].

The object of the research was to examine whether tumor cell membranotoxicity as regards splenocytes depends on the protein synthesis in the latter ones and whether it depends on the similarity or differences in the subregions of H2-complex. As effectors the following tumor cells transplanted in syngeneic mice were used: EL-4 (H-2b), MX-II (H2b), L-1210 (H2d), SA-1 (H2a). As target cells, the splenocytes from the following mice were used: B10/Sn, C57BL/6, B10.A (3R), B10.A (5R), B10.D2, B10.SM, CBA, B10. D2 (R 101), B10.D2 (R 107). It was shown that noncoincidence of the effectors and targets as regards the genetic basis, K, IA, IB, IJ, IE and D-subregions does not lower the maximal membranotoxicity inherent in the entire syngeneic system. Noncoincidence of the effectors and targets as regards the D-terminal of H-2 complex reduces more than 2-fold the effect of tumor cells on splenocytes. Thus, the coincidence of the effectors and targets only as regards the IC-subregion of H-2 complex is enough for attainment of the maximal membranotoxicity of tumor cell as regards splenocytes. It is discussed whether the injury to the target membrane (membrane toxicity) recorded in the research under consideration should be considered as cytotoxic (the target death) or as cytostatic. It is suggested that the phenomenon studied may underlie the immunosuppression due to tumor cells.