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Comparative effects of angiotensin and noradrenaline on resistance, capacitance, and precapillary sphincter vessels in cat skeletal muscle.

The effects of intra-arterially infused angiotensin II and l-noradrenaline on consecutive vascular sections were studied in a sympathectomized skeletal muscle region in the cat under conditions of constant perfusion pressure. Noradrenaline was found to be an effective constrictor of precapillary resistance vessels and capacitance vessels, but a poor constrictor of precapillary “sphincters”, whereas angiotensin was an effective constrictor of precapillary resistance vessels and precapillary “sphincters”, but a poor constrictor of the main capacitance vessels. Noradrenaline caused a net fluid absorption and angiotensin a net filtration across the capillaries which indicated that noradrenaline was a poor, but angiotensin an effective, constrictor of post-capillary resistance vessels.