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[Effects of different components of serum from radiation, burn and combined radiation-burn injury on L-type calcium channel of cultured myocardial cells].

The effects of different components of serum from radiation, burn and combined radiation-burn injury on the activity of L-type calcium channel in cultured myocardial cells were investigated in this study. The results revealed that the serum from different injury groups could all activate the L-type calcium channel of cultured myocardial cells. These changes altered the calcium level in cells, which might be an important cause of dysfunction in cardiovascular system. Among the components of postinjury serum, the effect of high molecular components (> 8-10 kD) was not significant, whereas low molecule (< 8-10kD) and lipid components were the major effective components. The low molecule of postinjury serum affected not only on the opening activity of L-type channel, but also on the state of molecular movement in the membrane. The effect of serum lipids from injury groups could be depressed by SOD, which suggests that there may be free radical reactions during the serum lipids effect on calcium channel. The effects of serum and its components from combined radiation-burn group were the most intensive, and those from radiation injury were the weakest. The nature of the toxic material in serum remains to be further investigated.