{'fraction_non_alphanumeric': 0.03567508232711306, 'fraction_numerical': 0.020856201975850714, 'mean_word_length': 5.7518518518518515, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Effect of the fastigial nucleus electrostimulation on the ability of learning and memory and the Apoptosis of the neurons in the hippocampal district in ratymodel of Alzheimer's Disease

Objective:To study the effects of the fastigial nucleus electrostimulation on the ability of learning and memory and the Apoptosis of the neurons in the hippocampal district in ratymodel of Alzheimer's D isease induced byβ-amyloid(Aβ).Methods:Forty rats were randomly divided into:Aβ1-40 micro-injection groups(AD),sham-operation roup(SC),Aβ1-40 micro-injection and fastigial nucleus stimulation group(FNS),a Aβ1-40 micro-injection and corpus dentatum stimulation group(DNS).The effect of fastigial nucleus electrostimulation on learning and memory retention disorder in the model rats was studied by the test of Morris water maze;the brain protection of fastigial nucleus electrostimulation in model rats was observed through pathomorphology changes;the Apoptosis of the neurons in the hippocampal CA1 district was detected by Terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling method.Results:The escape latency of the place navigation in the AD grou,FNS group and DNS group were singnificiantly longer than that in the SC group(P0.05).The number of apoptotic neurons in the hippocampal CA1 district of the AD group was significantly different from that in the sham injection group(P0.05).The AD rats received FNS showed significiant shorter escape latency than AD rat(sP0.05).The number of apoptotic neurons in the hippocampal CA1 district of the FNS group(22.55±2.74)was significantly different from that of the AD group(36.90±4.07)(P0.05).Conclusions:FNS can improve the spatial learning and memory dysfunction of AD rat,implying that FNS has the function to restraining the apoptosis of the hippocampal neurons.