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The Mona Lisa: an example of frontal fibrosing alopecia masquerading as Renaissance fashion?

The Mona Lisa has long attracted interest from the general population, and more recently the medical profession. In an attempt to find pathology in her enigmatic appearance, previous clinicians have proposed an underlying diagnosis of hyperlipidaemia or hypothyroidism. This is the first report of features consistent with frontal fibrosing alopecia (FFA) found in the Mona Lisa: namely high forehead, receding frontotemporal hairline, and lack of eyebrows. Given the higher prevalence of autoimmune conditions amongst patients with FFA, hypothyroidism may have coexisted. Alternatively, artistic artefact or technique, or the customary cosmetic practice of pseudoalopecia within the Renaissance period may explain her appearance, which will undoubtedly captivate her audience and invite speculation ad infinitum. This article is protected by copyright. All rights reserved.