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Acoustical characterization of submicron particles of perfluorocarbon in solution [ultrasound targeted contrast agent]

Determining the acoustical properties of submicron particles of perfluorocarbon in solution is important to explain their response to ultrasound pulses when bound to a target. In this study, we present measurements of the frequency-dependent attenuation at different particle sizes, pressures and bandwidths. Backscattering spectra of the particles probed with narrowband pulses at 33 MHz are also shown. This study demonstrates the linearity of submicron particles made of liquid perfluorocarbon at high frequency.