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Correlation between Tumor Angiogenic Activity and Its Significance in Primary Breast Carcinoma

Objective To study the relationship between tumor angiogenesis and its significance. Methods Intratumoral vascularization in 80 cases of breast cancer was observed preoperatively by power Doppler imaging (PDI) and analysed with computer assisted quantative assessment,and the expression of microvessel density (MVD) and VEGF protein were determined by immunohistochemical technique. Results 44.4% of the breast carcinoma was VEGF positive. Blood vessels postitive area and MVD in VEGF positive cases were higher than those of the negative ( P 0.01). All of them were not correlated with the clinicopathological factors but associated with histological grade of differentiation and axillary lymph node metastasis,whereas,negatively correlated with the five year survival rate ( P 0.01). Conclusion Power Doppler imaging (PDI) quantative assessement integrated with immunohistochemical S P method and the Weidner's method can observe intratumoral vascularization overall. Blood vessels postive area,microvessel density (MVD) and the expresssionOf VEGF may be good prognostic indicators for the patients with breast carcinoma.