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MR imaging of the liver with Gd‐BOPTA: Quantitative analysis of T1‐weighted images at two different doses

This study evaluates the efficacy of gadobentate‐dimeglumine (Gd‐BOPTA) for enhancement of liver signal‐to‐noise ratio (SNR) and lesion‐liver contrast‐to‐noise ratio (CNR) on T1‐weighted spin‐echo (SE) and gradient‐recalled‐echo (GRE) images at two different doses. Fifty patients with known or suspected liver lesions were examined at 1.5 T. T1‐weighted SE (TR/TE 300/12 msec) and GRE images (TR/TE80/4.2 msec/flip angle80°) were obtained before and at 40–80 minutes and 90–120 minutes after administration of 0.05 or 0.1 mmol/kg Gd‐BOPTA. Quantitative measurements of tissue signal intensity were performed at each dose. Liver showed significant enhancement after Gd‐BOPTA on T1‐weighted SE and GRE images (0.05 mmol: P < 0.05; 0.1 mmol: P < 0.001). The dose of 0.1 mmol/kg provided higher liver SNR than 0.05 mmol/kg. Mean liver SNR was higher on GRE than SE images (P < 0.0001). Lesion‐liver CNR significantly increased on GRE images after 0.1 mmol (P < 0.05). There was a trend toward superiority of 0.1 mmol over 0.05 mmol/kg. GRE images were superior to SE images for pre‐ and post Gd‐BOPTA lesion‐liver CNR (P < 0.05). Our study suggests that Gd‐BOPTA provides prolonged enhancement of liver SNR and CNR, that a dose of 0.1 mmol/Kg appears to be superior than 0.05 mmol/Kg, and that GRE techniques should be used in preference over SE techniques.J. Magn. Reson. Imaging 1999;10:80–83. © 1999 Wiley‐Liss, Inc.