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[Cyclic 3',5'-adenosine monophosphate in the liver of rats with experimental rheumatoid arthritis].

Content of cAMP was distinctly decreased in rat liver tissue within the first days of development of experimental rheumatoid arthritis (adjuvant arthritis). Within 6 days the content of cAMP was slightly increased in liver tissue of the arthritic rats but it was lowered 2-fold as compared with controls. The content of cAMP was quite unaltered during subsequent course of the impairment (within 25 days). In blood plasma of patients with rheumatoid arthritis the content of cAMP was decreased more than 2-fold as compared with its concentration in blood of donors. Possible importance of cAMP deficiency in pathogenesis of rheumatoid arthritis is discussed.