{'fraction_non_alphanumeric': 0.03569912140314205, 'fraction_numerical': 0.02113205082143907, 'mean_word_length': 4.92453560371517, 'pattern_counts': {'":': 0, '<': 3, '<?xml version=': 0, '>': 1, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 2, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Ambulatory sleep scoring using accelerometers—distinguishing between nonwear and sleep/wake states

Background Differentiating nonwear time from sleep and wake times is essential for the estimation of sleep duration based on actigraphy data. To efficiently analyze large-scale data sets, an automatic method of identifying these three different states is required. Therefore, we developed a classification algorithm to determine nonwear, sleep and wake periods from accelerometer data. Our work aimed to (I) develop a new pattern recognition algorithm for identifying nonwear periods from actigraphy data based on the influence of respiration rate on the power spectrum of the acceleration signal and implement it in an automatic classification algorithm for nonwear/sleep/wake states; (II) address motion artifacts that occur during nonwear periods and are known to cause misclassification of these periods; (III) adjust the algorithm depending on the sensor position (wrist, chest); and (IV) validate the algorithm on both healthy individuals and patients with sleep disorders. Methods The study involved 98 participants who wore wrist and chest acceleration sensors for one day of measurements. They spent one night in the sleep laboratory and continued to wear the sensors outside of the laboratory for the remainder of the day. The results of the classification algorithm were compared to those of the reference source: polysomnography for wake/sleep and manual annotations for nonwear/wear classification. Results The median kappa values for the two locations were 0.83 (wrist) and 0.84 (chest). The level of agreement did not vary significantly by sleep health (good sleepers vs. subjects with sleep disorders) (p = 0.348, p = 0.118) or by sex (p = 0.442, p = 0.456). The intraclass correlation coefficients of nonwear total time between the reference and the algorithm were 0.92 and 0.97 with the outliers and 0.95 and 0.98 after the outliers were removed for the wrist and chest, respectively. There was no evidence of an association between the mean difference (and 95% limits of agreement) and the mean of the two methods for either sensor position (wrist p = 0.110, chest p = 0.164), and the mean differences (algorithm minus reference) were 5.11 [95% LoA −15.4–25.7] and 1.32 [95% LoA −9.59–12.24] min/day, respectively, after the outliers were removed. Discussion We studied the influence of the respiration wave on the power spectrum of the acceleration signal for the differentiation of nonwear periods from sleep and wake periods. The algorithm combined both spectral analysis of the acceleration signal and rescoring. Based on the Bland-Altman analysis, the chest-worn accelerometer showed better results than the wrist-worn accelerometer.


INTRODUCTION
Accelerometers play an important role in psycho-sociological studies, especially in the fields of sleep health (Wrzus et al., 2012;Hees et al., 2018) and sedentary behavior (Rosenberger et al., 2013). To measure sleep via actigraphy, a device that can identify nonwear periods and differentiate nonwear and sleep periods should be used (Choi et al., 2011;Winkler et al., 2012;Gorman et al., 2014). To distinguish nonwear from sleep, studies often collect supplemental data in the form of a diary (Edwardson et al., 2017). Such methods attempt to capture the sleep/wake state of the participant, the sleep quality, and the times in which the device was not worn in an effort to refine the actigraphy data. These methods place a large burden on the participant and are often inaccurate. Participants are required to provide written notes of their activity during the study and to note the start and the end of bedtime by tapping on the sensor or pressing a button. The labor requirements of the researcher for data processing remain an important consideration because such methods complicate the implementation of batch analyses (Masse et al., 2005;Edwardson et al., 2017) . Problems also arise when secondary parameters for physical activity (PA) are calculated, especially in larger data sets that require automatic wear time detection algorithms (Matthews et al., 2002). The false classification of sleep or sedentary behavior as nonwear time distorts PA estimates and results in invalid estimates of accelerometer-derived measurements of PA (King et al., 2011).
Existing algorithms classify acceleration data into wear and nonwear periods by applying a threshold to a specific metric that is calculated from the acceleration signals for each epoch (e.g., 30 s or 1 min) of a measurement. These metrics (often defined as 'counts') vary substantially between device manufacturers (Sadeh, Sharkey & Carskadon, 1994;Troiano et al., 2008;Kripke et al., 2010). To refine this distinction, researchers have investigated different numbers of consecutive epochs. Troiano et al. (2008) defined nonwear as a 60minute period of consecutive minutes containing low levels of activity. Choi et al. (2011) indicated that a longer time frame of 90 min provided a better estimation of nonwear time, taking into account motion artifacts occurring during nonwear periods. Evenson & Terry (2009) observed that the propensity for low levels of physical activity to register while sleeping or sitting motionless makes sedentary and nonwear periods similar. In 2016, Kosmadopoulos, Darwent and Roach (2016) proposed an algorithm that can discern nonwear time from sleep or quiet wakefulness by comparing different periods of inactivity for a wrist-worn accelerometer (Kosmadopoulos, Darwent & Roach, 2016). In the same year, Winkler et al. (2016) presented an automated algorithm that can classify bouts of activity as nonwear and sleep periods based on knowledge of the behaviors that differentiate sleep from nonwear. The algorithm presented by Zhou et al., (2015) used both acceleration and surface skin temperature measurements to identify nonwear time. However, a temperature threshold should be calibrated for regional climates as well as for indoor/outdoor activities.
In another context, some studies have focused on extracting new features from the acceleration signal, such as the respiratory wave. With an acceleration signal that is sufficiently sensitive, a detailed analysis of the power spectrum can reveal additional features, particularly cyclical patterns such as breathing (Hung et al., 2008). Liu et al. proposed an algorithm that can determine the dynamic respiration rate during various physical activities using such an analysis. For our algorithm, we compared the existing methods of deriving the respiration rate from 3D acceleration signals, such as wavelet decomposition, non-adaptive bandpass filters and adaptive bandpass filters. Because various body motions may affect the acceleration signal, researchers combined hybrid principal component analysis (PCA) with adaptive bandpass filtering. They configured the parameters of the bandpass filter according to the energy expenditure of the individual during each physical activity (sleep, quiet sitting, sitting with minor movement, walking and running). Liu et al. investigated through their algorithm the possibility of detecting the respiration wave for different levels of activity (low, medium and high). The results confirmed that the respiration rate derived from 3D acceleration signals can withstand motion artifacts and thus can be used for ambulatory measurements (Liu et al., 2011).
After distinguishing nonwear from wear periods, the algorithm classifies remaining time into sleep and wake periods. A number of studies have focused on the usefulness of actigraphy in discriminating between sleep and wake as defined by the gold standard of polysomnography (PSG) (Mullaney, Kripke & Messin, 1980;Cole et al., 1992;Paquet, Kawinska & Carrier, 2007). The most commonly used algorithms for sleep/wake classification compare the level of activity in a defined window with a threshold or a regression algorithm based on statistical parameters derived from the acceleration signals. Sadeh, Sharkey and Carskadon proposed a regression algorithm based on the sleep/wake classification from PSG data. They used the following variables: the mean activity counts during the scored epoch and the window of five epochs preceding and following it, the standard deviation of activity counts during the scored epoch and the five epochs preceding it, the natural logarithm of the number of activity counts during the scored epoch + 1, and the number of epochs with an activity level with between 50 and 100 activity counts in a window of 11 min that includes the scored epoch and the five epochs preceding and following it (Sadeh, Sharkey & Carskadon, 1994). Cole et al. (1992) computed the weighting factors from the activity scores for a given minute, the following minutes and the previous minutes, and proposed rescoring rules to increase the accuracy rate of correct sleep/wake classification. To improve those algorithms, different decision rules have previously been proposed to differentiate bedtimes from wake times (Catrine et al., 2014) and waking wear times (McVeigh et al., 2016;Winkler et al., 2016). We focused our definitions of the rescoring rules on the common reasons behind the misclassification of sleep periods as nonwear periods (the power spectrum not being examined for respiration signals during sleep) and sleep periods as wake periods (short movements during bedtime).
To discern nonwear from sleep, existing algorithms focus on activity counts derived from the acceleration signal. The limitations of this approach include the misclassification of nonwear periods when motion artifacts are present and the inability to classify long periods of inactivity. Given the limitations of the algorithms described above, we aimed to distinguish nonwear periods from sleep periods. Therefore, we extracted a new feature from the acceleration signal and studied its ability to differentiate nonwear periods from sleep and wake periods.

Participants and procedure
The study included 98 participants. The healthy subjects were recruited by word of mouth. The subjects with sleep disorders (insomnia, sleep apnea, parasomnia and restless legs syndrome) were patients in the sleep medicine clinic at the University of Albert-Ludwig Freiburg Medical Center. The Ethics Committee of the University of Albert-Ludwig Freiburg granted ethical approval to carry out the study within the university facilities (Ethical Application Ref: 141/15). Written consent was obtained from the participants.
We recorded acceleration data using the activity sensor Move3 (movisens GmbH, Karlsruhe, Germany), which was worn by the participants on both wrist and chest for one day of measurements. The accelerometers sampled the data at 64 Hz with a measurement range of ±8 g. Polysomnographic recordings were scored using the standard AASM rules (Iber et al., 2007). The participants spent one night in the sleep laboratory at the University of Albert-Ludwig Freiburg Medical Center. In the morning, an assistant recorded the nonwear periods while the participants were taking a shower. For the remainder of the day, the participants continued to wear the sensors outside of the laboratory. To identify nonwear periods occurring outside of the sleep laboratory, we referred to a change in the temperature signal from the sensor from the constant room temperature (detecting a decreasing exponential function at the beginning and an increasing exponential function at the end of a nonwear period) and a visual evaluation of acceleration signal (Boyne et al., 2013). The PSG results served as a reference for the sleep and wake periods.
In this work, we defined an ''epoch'' as a basic time segment with a fixed length of 30 s, a ''window'' as a time segment composed of a fixed number of consecutive epochs (e.g., 10 min or 20 min), and a ''period'' as an undefined number of consecutive epochs (e.g., a period of sleep, a period of wake).

Statistical analysis
The statistical analyses were performed in R (Version 3.4.1). The normality of the data was tested for each study group separately using the Anderson-Darling normality test. To describe the demographic data, the categorical variables were summarized as counts, and the continuous variables with nonnormal distributions were expressed as medians and IQRs. To compare the two study groups (healthy subjects vs. patients with sleep disorders), the chi-square test was used for nominal data, and the Mann-Whitney U test was used for continuous data with a nonnormal distribution.
The goal of the study was to investigate the agreement between the actigraphy-based algorithm and nonwear annotations. Therefore, we evaluated the kappa values for each participant (reported as median and 25th and 75th percentiles because these data were and ''almost perfect'' if kappa>0.80 (Landis & Koch, 1977). We then compared the kappa values across different groups (sex, healthy subjects/patients with sleep disorders) using the Mann-Whitney-U test with a significance level of p < 0.05. Furthermore, we compared the total nonwear time from the actigraphy-based algorithm versus the annotation using the Bland-Altman approach (Bland & Altman, 1986) to calculate the mean of the difference and the 95% limits of agreement. We also presented the linear regression results of the difference in the mean and 95% limits of agreement. Finally, we determined the intraclass correlation coefficient (ICC) (model ''two-way'', type ''agreement'', effect ''random'') to assess the interrater reliability (Koo & Li, 2016) and the Pearson correlation coefficient to evaluate the linear relationships of total nonwear time between the algorithm and the reference.
For the sleep/wake analysis, as the PSG is the gold standard, we evaluated sensitivity, specificity, the positive predictive value, the negative predictive value, informedness (two-class analysis), accuracy, and the kappa value. We also performed an epoch-by-epoch (30 s) analysis by computing the confusion matrix (Kohavi & Provost, 1998).

Algorithm
Structuring the proposed algorithm required precise observations of sleep and nonwear periods and considered the main differences between them. The composition of the algorithm consisted of the following steps: 1. Collect raw 3D accelerometer data at a sampling rate of 64 Hz and resolution of 4 mg. 2. Preprocess the signal by using bandpass filters (Butterworth filter: frequency = 0.25-3 Hz, order = 4), threshold-crossing (threshold = 0.015 over 30 s). 3. Apply the nonwear detection algorithm. 4. Apply the sleep detection algorithms. 5. Apply the rescoring rules to correct misclassifications.
We used five sets of measurements that were acquired during the study but were not included in the evaluation to graphically determine the thresholds by trial and error. The participants wore the same devices and followed the same protocol as described in the study. These measurements were chosen randomly.

Nonwear algorithm
We evaluated the power spectrum of the three-dimensional acceleration signal to identify nonwear epochs. The power spectrum for wake and sleep periods showed a high amplitude in the 0.1 Hz-0.4 Hz frequency range (representing the range of respiration frequencies), and the power spectrum of the nonwear periods showed a low intensity across the total frequency range. We used this observation to discern nonwear epochs by identifying a reduced power spectrum in the 0.1 Hz to 0.4 Hz range. The power within this frequency band was computed for each signal (x,y,z) over a 10-minute window. Afterwards, the maximum power Pmax was determined as the maximum power over the three axes. We classified the event as nonwear if the maximum power Pmax fell below the threshold P0 = 2*10 −5 :

Sleep algorithm
After applying a 0.25-3 Hz bandpass filter to the accelerometer signal, a specific metric (we used threshold-crossing) was calculated over each 30-second epoch. Within each sliding window of 20 min, the number of epochs with zero metrics were summed and compared with the threshold Th0 = 15. If the resulting value was above Th0, the window was classified as a sleep window. For the longest sleep period in the day (from noon to noon), sleep onset was defined as the first ten consecutive sleep epochs.

Rescoring rules
To develop the automated sleep time and nonwear time detection algorithm, we used the calculations for nonwear and sleep time and then implemented the following rescoring criteria (Fig. 1): 1. Incorrectly classified nonwear epochs occurring during sleep were rescored. First, we identified the nonwear period (surrounded by sleep periods). Then, we analyzed the power spectrum of the period, and if 75% of the nonwear period indicated respiration, we reclassified the period as a sleep period. This verification step prevented the misclassification of a real nonwear period during sleep, where the subject removed the sensor for a short period and replaced it. 2. Misclassifications of a nonwear period occurring at bedtime or just before bedtime (i.e., the participant removing the sensor just before or after entering the bed) were corrected. After identifying the period (presenting unusually high activity from one side), the whether the power spectrum indicated respiration for over 75% of the period was assessed. 3. Movements lasting longer than one minute during sleep were considered as movements occurring during wake.

RESULTS
The study involved 98 participants: 55 males and 43 females with a median age of 28.5 years (range 19-63 years, IQR 15.7 years). We split the data into three subsamples for the analyses. The first sample contained all subjects (98), the second only healthy subjects (48), and the third consisted of patients with sleep disorders (50). We excluded 5 subjects due to a lack of annotation of the sleep periods. we used an epoch length of 30 s and compared the concordance of the actigraphy-based classification algorithm with the PSG data and nonwear annotations. The rows of the confusion matrix present the wake, sleep and nonwear classes as determined by the PSG data and nonwear annotations, and the columns contain the classes of the epochs as determined by the actigraphy data. Among all the nonwear epochs, 90.1% and 93.5% were identified as nonwear, 2.0% and 0.0% as sleep, and 7.8% and 6.4% as wake for the wrist and chest, respectively. Of all the sleep epochs, 92.2% and 97.1% were classified as sleep, 0.2% and 0.02% were classified as nonwear, and 7.5% and 2.8% were classified as wake for the wrist and chest, respectively. Moreover, among all of the wake epochs, 87.9% and 85.4% were classified as wake, 10.8% and 13.8% as sleep, and 1.2% and 0.6% as nonwear for the wrist and chest, respectively ( Table 2, Table 3).   The algorithm achieved a median sensitivity of 0.92 and 0.95 for the wrist and chest, respectively, and a specificity of 1, 0.99 for nonwear; a median sensitivity of 0.90 and 0.87, respectively, and specificity of 0.94, 0.98 for sleep; and a median sensitivity of 0.93 and 0.97, respectively, and specificity of 0.90, 0.88 for wake (Tables 4 and 5). The median accuracy was 0.90 and 0.91 for the wrist and chest, respectively, and the median kappa values were 0.83 and 0.84, respectively. ''Almost perfect agreement'' occurred for 63.4% and 67.7% of the participants, 33.3% and 27.9% of the participants had ''substantial agreement'', and 3.2% and 4.3% of the participants had ''moderate agreement'' for the Barouni   wrist and chest, respectively. There were no occurrences of ''poor agreement'' and ''fair agreement'' (Landis & Koch, 1977) . We compared the performance of the classification algorithms across several participant characteristics. Agreement did not vary significantly by sex (p = 0.215 and p = 0.456 for the wrist and chest, respectively) or by study group between the healthy subjects and patients with sleep disorders (p = 0.348 and p = 0.118) ( Table 6). Then, we constructed Bland-Altman plots for each sensor position to assess the differences in nonwear time per day between the algorithm and the reference (Figs. 2  and 3). For wrist-and chest-worn accelerometers, the mean differences (algorithm minus reference) were 0.7 [95% LoA −29.7-31.3] and −0.5 [95% LoA −16.9-15.9] min/day, respectively. The linear regression results of the difference in the mean and the 95% LoA showed an upward trend for higher measurements. The intraclass correlation coefficient between the algorithm and the reference was 0.92 (95% CI [0.88-0.94], p < 0.001) for the wrist and 0.97 (95% CI [0.95-0.98], p < 0.001) for the chest (Table 7). We also investigated the Bland-Altman plots after removing 12 and 8 outlier measurements for the wrist and chest, respectively, that had inaccurate counts of nonwear epochs (Figs. 4 and 5). These inaccuracies occurred due to misclassifications of short nonwear periods that were directly adjacent to sleep periods and were thus considered as sleep periods and misclassifications of nonwear periods with unusual high levels of activity that were thus classified as wake periods. For the wrist-and chest-worn accelerometers, the slopes of the linear regressions

DISCUSSION
This study evaluated a newly developed automated algorithm for nonwear/sleep/wake classification based on acceleration data recorded from different locations on the body (wrist and chest). A frequency spectrum-based algorithm (Liu et al., 2011), which combined hybrid PCA and adaptive bandpass filtering, was designed to estimate the respiratory rate according to body activities (sleep, quiet sitting, sitting with minor movements, walking and running) within the range 0.2-0.7 Hz. In our work, we implemented the same principle to discern nonwear epochs from wear epochs by studying the power spectrum of the acceleration signal and determining an estimation of the respiration rate. We found that a power spectral analysis within the range 0.1-0.4 Hz was sufficient for nonwear/wear classification, as the spectrum presented a low power in this range when the sensor was not worn. However, we noted from the confusion matrix of the epoch-by-epoch classification of the three states nonwear/sleep/wake (Tables 2 and 3) that nonwear was more often wrongly classified as wake (7.8%, 6.4%) than as sleep (2.0%, 0.0%). The misclassification of nonwear as wake could also occur via the accumulation of long movements during nonwear periods, with participants relocating the sensor, especially at the beginning and end of a nonwear period, resulting in the appearance of a high power in the range 0.1-0. Hz. The analysis of total nonwear time indicated that the upper 95% LoA is half as large for chest-worn sensors versus wrist-worn sensors. As other studies have noted that wrist monitors are less biased than waist monitors (Choi et al., 2012), the algorithm based on the spectral analysis of the respiration wave may be more appropriate for chest-worn sensors. The 95% LoA was shorter than 32 min for both the wrist-and the chest-worn sensors. This result means that wear periods were classified as nonwear periods due to the absence of the respiration wave by the spectral analysis. Those periods were mostly present during sleep when the sensor was removed. As different studies have suggested the use of 90 min (Choi et al., 2012) or 60 min (Keadle et al., 2014) of consecutive zeros as the criterion, we can conclude that the bias had no practical significance. According to the comparison of the Bland-Altman plots before (Figs. 2 and 3) and after the removal of the outliers (Figs. 4 and 5), the bias was not constant over the range of values before the outliers were removed. When short nonwear periods were directly adjacent to sleep periods, the algorithm considered them to be sleep periods due to the lack of large changes in activity between the two periods. In fact, the investigated period included both sleep and nonwear. Therefore, after the second rescoring rule was applied, the respiration signal derived from the power spectrum covered more than 75% of the period and thus enabled the classification of the period as sleep. This result led to the conclusion that the second rule should be revised either by adjusting the percentage value from 75% or by defining a new method to adjust the limits of the period suspected to be a nonwear period. Annotating the nonwear periods using only a diary as a reference required the verification of compliance and whether the time-stamps in the diary matched those derived from the acceleration signal (Masse et al., 2005) . To improve the quality of nonwear annotations, we referred to visual assessments of the acceleration signal (to find long continuous bouts of inactivity) (McVeigh et al., 2016) and a visual examination of the temperature signal, which showed a decreasing exponential function at the beginning of the nonwear period and an increasing exponential function immediately after the activity sensor was donned. This finding introduces the question of why researchers do not use temperature instead of acceleration to identify nonwear from wear periods or combine both methods. Zhou et al. presented the performance of classification algorithms based on acceleration and temperature data, first separately and then combined. While the classification algorithm based on temperature showed a higher value for sensitivity (0.93) than for specificity (0.64), the classification algorithm based on acceleration had a sensitivity of 0.76 and a specificity of 0.89. By combining both methods, a sensitivity of 0.94 and a specificity of 0.91 were achieved (Zhou et al., 2015). However, the variation in temperature from situations such as indoor or outdoor activities can impact the performance of the combined classification algorithm. The performance depended on the temperature, which makes it difficult to use the algorithm in different climate conditions. On the other hand, our classification algorithm, based only on acceleration data, achieved similar sensitivity and specificity as the classification algorithm based on a combination of acceleration and temperature data. After defining nonwear epochs, we discerned sleep from wake based on the level of activity within a defined timeframe using a simple threshold-based algorithm. The thresholds of the algorithm were determined using PSG, which is the gold-standard measure of sleep parameters for laboratory research and is the best method for validating other classification methods, such as activity sensors. At the end of the algorithm, we proposed rescoring rules based on visual assessments to correct the misclassifications accrued by traditional classification algorithms due to issues such as motion artifacts that occur during nonwear periods (e.g., when the sensor is nudged or touched while being placed on a table or nightstand) and long motionless periods with sporadic movements during sleep.
Nonwear/sleep/wake classification studies differ in how the reference is collected. In (McVeigh et al., 2016), in-bed periods (the period from when the participants went to bed to the time at which they arose from the bed) were identified by two independent raters, and these periods included the time the participant spent trying to fall asleep, the time he or she was asleep, and the duration of wakefulness after sleep onset. When PSG is used as a reference, sleep time can be accurately identified, as PSG reports in-bed time as well as sleep time. However, PSG remains restricted to sleep laboratories, and sleep periods during the day (e.g., napping) cannot be classified. Thus, visual identification or diaries remains essential for determining the reference data for sleep/wake analyses from data in real world environments outside of the lab. We also found that 10.8% (for the wrist) and 13.9% (for the chest) of the wake epochs, e.g., epochs occurring during long motionless periods of wakefulness (insomnia) or between the beginning of an in-bed time period and sleep onset, were misclassified as sleep epochs. Nevertheless, an additional feature is needed to accurately determine sleep onset times, even though we defined sleep onset as the beginning of ten consecutive sleep epochs.

LIMITATIONS OF THE STUDY
The wrist-and chest-worn accelerometer data were collected in a sleep laboratory, which can influence the behavior of the participants. We had no additional information about sleep periods occurring during the day, as the sleep reference data was defined based only on PSG measurements, which is the gold-standard method of assessing sleep. The rest of the day was thus considered as wake time. The annotations of the nonwear reference was performed manually based on knowledge of the study procedure (report of the assistant in the sleep laboratory), the visual assessments of acceleration signal and temperature signal and were therefore inaccurate. However, the combination of both methods allowed more accurate nonwear references. The thresholds presented in the algorithm were determined from data that was collected as part of the study from different participants but was not used in the analyses. The acceleration signal was collected from one sensor brand, which  can influence the choice of the thresholds and the results when using the algorithm with other sensors presenting different noise levels.

CONCLUSION
Using accelerometers yields new insights and opportunities in a wide range of psychosociological studies, especially in the field of sleep health. We propose an algorithm that can differentiate nonwear periods from sleep and wake periods based on the detection of the respiration wave. Future studies should focus on sleep and wake classification using other complementary methods besides threshold-based methods, such as frequency analysis of the acceleration signal and differences in respiration patterns, during sleep and wake states as well as during sedentary behaviors, as this information is especially valuable when short nap periods are of interest in the context of ambulatory studies. These methods could also be used to determine the exact start and end times of sleep using acceleration data.

ADDITIONAL INFORMATION AND DECLARATIONS Funding
The research was done as part of the research KMU innovative project ''SleepCoach" that was funded by the German Federal Ministry of Education and Research (BMBF) (grant no. 16SV6389K). There was no additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.