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Quantifying inter‐species differences in contractile function through biophysical modelling

To facilitate translation of data from animal models into clinical applications, it is important to analyse and quantify the differences and relevance of specific physiological mechanisms between species. We propose a novel approach for the quantification of inter‐species differences in terms of biophysical model parameters and apply this to elucidate the differences in cardiac contraction mechanisms between mouse, rat and human. Our results indicate that the parameters related to the sensitivity and cooperativity of calcium binding to troponin C and the activation and relaxation rates of tropomyosin/crossbridge binding kinetics differ most significantly between mouse, rat and human. Our results predict crossbridge binding to be slowest in human and fastest in mouse.