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The Genesis of Anterior Chamber-Associated Immune Deviation

Wayne Streilein’s interest in ocular immunology began with the study of the intraocular inflammation induced by the lymphocyte transfer reaction while in the Department of Cell Biology at the University of Texas Southwestern Medical School in 1973. The injection of parental (A) lymphocytes into the anterior chamber of F1 hybrid rats (A × B) resulted in F1 lymphocyte inducedimmune deviation, an immunologic phenomenon that evolved into the study of anterior chamber-associated immune deviation (ACAID).