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Do mucolytics help in chronic bronchitis and asthma?

Mucolytic drugs reduce the viscosity and elasticity of mucus. In prescribing a mucolytic the clinician hopes to facilitate sputum expectoration and to unblock airways that are plugged with mucus, thus reducing airways resistance, improving ventilation and perhaps helping to prevent infection. We here consider whether mucolytics help patients with chronic bronchitis and asthma who remain symptomatic after conventional treatment.