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Premature Fusion of the Spheno-Occipital Synchondrosis (SOS) and Midface Hypoplasia in Syndromic Craniosynostosis

IntroductIon: The spheno-occipital synchondrosis (SOS) is a key driver of cranial base and mid-facial development. Its premature fusion has been associated with midface hypoplasia in animal models, and there is growing evidence that it plays a role in midface hypoplasia associated with syndromic bicoronal craniosynostosis in humans. The purpose of this study was to compare CT scans of patients with Apert’s Syndrome, all of whom had midface hypoplasia, to a cohort of non-syndromic bicoronal craniosynostosis patients, none of whom had midfacial hypoplasia, to determine if there is a difference in timing of closure of the SOS.