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Effects of beta-amyloid peptide on transient outward potassium current of acutely dissociated hippocampal neurons in CA1 sector in rats.

OBJECTIVE
To explore the mechanism of beta-amyloid peptide (beta-AP) in Alzheimer's disease at ionic channel level.


METHODS
Hippocampal CA1 neurons of 7-21 days' rats were acutely dissociated and the effects of beta-AP on transient outward potassium current were observed by a whole-cell recording patch clamp technique.


RESULTS
beta-AP can significantly block transient potassium current in dose-dependent, time-dependent and partly voltage-dependent manners.


CONCLUSION
beta-AP may decrease the membrane conductance of K+ channels in hippocampal neurons, playing an important role in the pathophysiological mechanism of Alzheimer's disease.