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Zinc supplementation and inflammatory cytokines

We read with interest the article of Faghfouri et al. (1) regarding the “Profiling Inflammatory Cytokines Following Zinc Supplementation: A Systematic Review and Meta-analysis of Randomized Controlled Trials” and we would like to point out three concerns regarding the study selection presented in this article. First, although the authors searched electronic databases (PubMed, Scopus, Web of Science, and Embase), three eligible studies were ignored (2; 3; 4) . Second, the authors mentioned that non-randomized design studies and also articles conducted on juvenile subjects (10-19 years) (5) were excluded; however, two articles were included in the analysis (6; 7) . Third, another article was carried out on pregnant women, (8) which should be excluded from analysis because the condition of inflammatory cytokines and also the effect of supplementation on pregnant women are relatively different from non-pregnant adults. In view of the deficiencies mentioned above, it is suggested that the analysis should be repeated.