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Spatial navigation and verbal memory are influenced by the combined effects of APOE and BDNF Val66Met polymorphisms in mild cognitive impairment

The apolipoprotein E (APOE) ɛ4 allele is associated with an increased risk of Alzheimer’s disease (AD), episodic memory deficits and less accurate spatial navigation in non‐demented older adults. The brain‐derived neurotrophic factor (BDNF) Val66Met polymorphism is also related to the increased risk of AD and more pronounced memory impairment but its role in APOE ɛ4‐related spatial navigation deficits has not been established. Our aim was to examine the influence of combination of APOE and BDNF Val66Met polymorphisms on spatial navigation and other cognitive functions in individuals with amnestic mild cognitive impairment (aMCI).