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Concentration of amphetamine isomers in brain and heart of adult and developing mice.

The levels of d- and 1-amphetamine in the brain and heart of adult and developing mice aged 3–6 days and 13–16 days were studied. More d- than 1-isomer was found in the brain of developing mice, except after a dose of 100 mg/kg of the drug, i. e. a dose which produces a higher level of 1-amphetamine in the brain of 13–16-day-old mice. Adult brain retained 1-amphetamine in a higher concentration than d-amphetamine. In the youngest mice 50 mg/kg of the isomers produced equal levels of the drug in the brain and heart, whereas 100 mg/kg of the d-form was particularly concentrated in the infant heart. In the older age groups the brain level of either isomer was generally higher than the respective heart level. The age- and dose-dependent differences in the distribution of amphetamine isomers emphasize the importance of peripheral component of amphetamine action in the youngest mice and reveal a low sensitivity of the central nervous system to 1-amphetamine in 13–16-day-old as well as in adult mice.