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Radioactive tissue changes induced to control experimental hydrocephalus.

✓ Hydrocephalic animals were given an intraventricular infusion of radioactive colloidal gold and then sacrificed up to 7 weeks after infusion. Histological evaluation revealed progression from a marked hemorrhagic necrosis of choroid plexus vessels and stroma to eventual replacement by fibrous connective tissue, sclerosis, and fibrinous degeneration of stromal vessels. Particulate colloid was found engulfed in perivascular spaces in the subependymal periventricular tissues, but there was no evidence of vascular damage, gliosis, or demyelination. These findings may play a role in decreasing cerebrospinal fluid production.