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Ferritin Polymers and the Formation of Haemosiderin

Summary. When ferritin is isolated from Chang liver cells in culture iron loading is found to be associated with changes in the surface of the protein shell characterized by a change in immunoreactivity to anti ‘heart’and anti ‘spleen’antibodies at each specific pI and an overall shift in isoferritins to a lower pI range (Hoy & Jacobs, 1981). Ferritin polymers have been isolated from human tissues and their biochemical properties assessed in terms of these surface changes and the iron/protein ratio of the molecules.