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Furosemide pharmacokinetics and its relevance to ototoxicity.

Our earlier studies have demonstrated a possible pharmaco­kinetic explanation for the rate dependent ototoxicity of furose­mide. The present study was carried out to find out possible role of plasma protein levels and drug protein binding in furosemide pharmnacokinetics and toxicity. Twenty patients with different pro­tein patterns were given furosemide intravenously at different rates and doses. Plasma furosemide levels were fluorimetrically estimated in serial blood samples. The results indicate that dose and rate of administration and extent of binding to plasma proteins alter furosemide pharmacokinetics and the chances of toxicity are greater in hypoproteinemic patients.