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Nucleotide sequence of rat renin cDNA.

We have isolated cDNA clones for renin from a Sprague-Dawley rat kidney cDNA library containing a large amount of renin poly(A)+RNA induced by treatment of captopril and low sodium diet as described( 1 ) . A recombinant xongC library was screened with the mouse cDNA as a probe (2). A nucleotide sequence of the isolated cDNA was completely consistent with that deduced from the rat renin gene (3), and almost with that of the previous report(4), except for the followings: seven nucleotides in the coding and 3'-noncoding region including a polyadenylation site. Three of these seven nucleotide changes did alter two of the deduced amino acid sequences (indicated by boxes). M