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[Alteration of serum bactericidal effect of mice with experimental pyelonephritis].

Keisuke Kondo Department of Urology, Tokushima University, Medical School (Director: Prof. K. Kurokawa) We produced experimental pyelonephritis by the injection of coli form bacteria in the following four groups of mice: 1) a group of injection into the tail vein, 2) a group of injection into the tail vein after ligating the unilateral ureter, 3) a group of injection into the renal pelvis, 4) a group of injection into the renal pelvis after ligating the unilateral ureter. The serum bactericidal effects were studied and at the same time the numbers of bacteria and histologic findings of the kidney were compared. Marked decrease of the serum bactericidal effects was recognized temporarily in the all groups immediately after the infection. In the group of injection into the tail vein, the decrease of the serum bactericidal effects were recognized in 70% of the animal after two weeks to two months, and pictures of inflamation were recognized histologically in 15-50% of the animals. Bacteria in the kidney could not be found. In the group of injection into the tail vein after ligating the unilateral ureter, pictures of inflamation were recognized histologically in over 50% of the animals after two months, and on the other hand the serum bactericidal effects were disturbed in 35% of the total cases. In the group of injection into the renal pelvis, the disturbances of the serum bactericidal effects were recognized in 100% of the animals after one to five days of the infection, and the serum bactericidal effects returned to normal levels within 14 days with decreases of pictures of pyelonephritis and numbers of bacteria in the kidney in the all cases. In the group of injection into the renal pelvis after ligating the unilateral ureter, pictures of pyelonephritis and bacteria in the kidney were recognized in high frequency during 2 months, neverthless the serum bactericidal effects increased gradually after five days and returned to normal in two months.