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Vasoactive agonists exert dynamic and coordinated effects on vascular smooth muscle cell elasticity, cytoskeletal remodelling and adhesion

This study demonstrates rapid and dynamic changes in adhesion and cell elasticity following agonist stimulation that culminate in a remodelled cytoskeleton in vascular smooth muscle. Evidence is presented that the changes in adhesion and elasticity are coordinated and that these variables demonstrate temporal oscillation consisting of three major oscillation components. Eigen‐decomposition spectrum analysis revealed that these components of oscillation in cell elasticity and adhesion may be linked by shared signalling pathways. Evidence is provided that the agonists angiotensin II and adenosine produce remodelling of actin cytoskeleton that may alter the properties of the observed oscillations in elasticity and adhesion. It is concluded that angiotensin II and adenosine may regulate extracellular matrix adhesion and elasticity in vascular smooth muscle cells as a form of adaptation to more efficiently support contractile behaviour.