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Transcriptional regulator PGC1α regulates amino acid metabolism activated by exercise in skeletal muscles

Skeletal muscles play important roles not only in exercise and nutrition metabolism, but also in human health. Peroxisome proliferator‐activated receptor (PPAR) γ coactivator 1α (PGC1α) is a coactivator of various nuclear receptors and other transcription factors, whose expression increases in the skeletal muscles during exercise. We have previously made transgenic mice overexpressing PGC1α in skeletal muscles (PGC1α‐Tg mice). PGC1α Tg mice showed increased red fiber and capacity for longer treadmill running. In this study, we analyzed metabolic changes of skeletal muscles in PGC1α‐Tg mice by global gene expression (microarray) and metabolomic analyses.