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Neural tube defects: considerations on the pathogenesis and correlation with myelodysplasia in man. II. An experimental model.

In this second part, the authors report the results obtained by evaluating the presence of glycosaminoglycans (GAGs) in the brain of rat fetuses with neural tube defects and hydrocephalus, secondary to the administration of trypan blue during pregnancy. A decrease in the GAG content was found. The authors hypothesize that this anomaly in GAG formation is responsible for both the neural tube defect and the associated malformations, namely hydrocephalus and hypoplasia of the posterior cranial fossa.