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The distribution and retention of 249 Cf in beagle soft tissue.

Abstract Beagles injected intravenously with 249Cf in citrate buffer of pH 3.5 were sacrificed 7 days and 3 weeks after injection. As with americium, the concentration of californium in the liver was highest of all soft tissue but the total was about 18–20%, whereas the beagle liver retains about 50% of injected americium at comparable times. Concentrations in other soft tissue ranged from 70% of that in the liver downward. The thyroid, kidney, spleen, lymphatic tissue and dura mater showed significant concentrations. The presence of californium was ubiguitious but in very low concentrations throughout all other soft parts; the brain, lungs, heart, gastrointestinal tract, pancreas, gonads, thymus, pituitary and adrenals being measured specifically, as were large samples of fat, muscle and pelt. From these initial studies it is seen that of the soft tissues, liver, thyroid and kidneys will be at greatest risk following administration of 249Cf.