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Segmental changes in smooth muscle contraction as a predictive factor of the response to high‐dose proton pump inhibitor treatment in patients with functional chest pain

Background and Aims:  High‐dose proton pump inhibitor (PPI) treatment leads to relatively little symptomatic improvement in patients with functional chest pain (FCP). This study was to evaluate the use of smooth muscle segmental changes in esophageal contraction as measured by topographical plots of high resolution manometry (HRM) as predictive factors of the response to high‐dose PPI treatment in FCP patients.