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[The pathophysiological and biochemical changes in critical ischemia of the lower extremities].

In atherosclerosis there occur changes in hemodynamics [34], blood rheology [29], functional condition of the endothelium, thrombocytes and leukocytes [7, 13], in the blood coagulation system [1, 2]. In the presence of vascular affections of the lower part of the body the above changes make for development of critical ischemia of the inferior limbs, which, in its turn, aggravates the above-mentioned disorders.