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An approach to the pathogenesis of "white finger" induced by vibratory stimulation: acute but sustained changes in vascular responsiveness of canine hindlimb to noradrenaline.

A fixed vibratory stimulation (60 Hz in frequency, 3 g in acceleration, and 2.2 mm in amplitude) was applied to a hindlimb (test limb) of dogs anaesthetised with sodium pentobarbital. Peripheral vascular resistance in the test limb was calculated as the ratio of mean pressure difference between the femoral artery and the femoral vein to the rate of femoral arterial blood flow. By means of a highly sensitive clinical thermometer, interdigital temperature was recorded not only from the test limb but also from a forelimb (control limb). The vibratory stimulation significantly reduced the peripheral resistance in the test limb. The increase in peripheral resistance induced by noradrenaline administration was suppressed during, and enhanced 1 h after, the stimulation. With the start of the vibratory stimulation, interdigital temperature in the test limb rose gradually and reached a constant level. The temperature first went below, and then returned to, the initial level after interruption of the stimulation. No change in the temperature was produced in the control limb. The decrease of temperature induced by noradrenaline administration was suppressed during, and enhanced 1 h after, the stimulation. These results indicate that, even in the living body, the conclusion of our previously report is valid: ie the responsiveness of arterial smooth muscle to noradrenaline decreases during, and increases soon after, vibratory stimulation. Assuming that our results obtained from acute experiments can be applicable to human digital arteries, the occurrence of "white fingers" on vibration disease may be understood in terms of vibration-induced hyperresponsiveness following stimulation.