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The Pathophysiology of the Schizophrenic Disorders : Perspective from the Spectrum By :

Objective: This overview focuses on neurobiologic abnormalities found in subjects with schizotypal personality disorder, the prototype of the schizophrenia spectrum disorders, and chronic schizophrenia in the context of common vulnerabilities shared by SPD and schizophrenia, as well as those factors that protect against the severe cognitive/social deficits and frank psychosis of chronic schizophrenia. A pathophysiologic model of the relationship between schizotypal personality disorder and schizophrenia is developed on the basis of this data.