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Nucleotide sequence of a cDNA clone of Xenopus platelet-derived growth factor A-chain.

The nucleotide sequence of a cDNA clone homologous to the A-chain of the human platelet derived growth factor and isolated from a Xenopus oocyte cDNA library (1) is presented. The leader peptide is coded for by nucleotides 14-79, prepro sequences are coded for by nucleotides 80-286 and the mature protein is coded for by nucleotides 287-658. This clone is homologous to the long form previously described (2) but it is missing a 33 nucleotide insertion beginning at nucleotide 604.