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Long-term follow-up of children born with sporadic congenital hypothyroidism.

Congenital hypothyroidism (CH) is a pediatric endocrine disorder of newborns caused by a failure in the production of thyroid hormone (TH), an essential hormone for early brain development. Formerly a leading contributor of mental retardation due to delayed diagnosis and treatment, CH is now identified at birth through screening programs and so has much milder consequences. In my presentation, I will describe: a) the persisting neuropsychological sequelae despite screening, b) related mechanisms, c) four systems that account for the present phenotype.