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Activity of gamma-glutamyl transpeptidase in the diagnosis of alcoholism

To diagnose alcoholism, mainly clinical methods of examination of patients are used. At the same time, more and more attention is paid to the development of biochemical tests in order to assess the disease more objectively. A number of studies have studied the effect of alcohol abuse on the activity of serum gamma-glutamyl transpeptidase (g-GTP). This enzyme is widely distributed in organs and tissues, which accounts for the lack of specificity of the test. Serum g-GTP activity has been shown to be elevated in all types of hepatobiliary disorders, including hepatitis, cirrhosis, congestion, metastasis, as well as in pancreatitis, chronic nephritis, etc. Hepatic gGTP is an enzyme sensitive to the effects of ethyl alcohol, and therefore can serve as an objective test for identifying alcohol abusers.