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Modification by extraluminal and intraluminal N G nitro L arginine of neurally induced pressor response of mesenteric artery segments

AIM To observe the effects of extraluminal and intraluminal N G nitro L arginine ( L NA) on electrical stimulation induced pressor response in perfused rat mesenteric artery segments. METHODS The perfusion pressure was measured via a pressure transducer placed upstream of the artery segment from rat on an inkwriting oscillograph.RESULTS In isolated, perfused rat mesenteric artery segments, intraluminal infused L NA potentiated the pressor response to transmural electrical stimulation, as did extraluminal L NA. L arginine reversed the potentiating effect of L NA. Intraluminal L NA did not increase the basal pressure and the response to norepinephrine. The arterial endothelium and media do not seem to interfere with the access of intraluminal L NA to perivascular nerve terminals. CONCLUSION Intravenously applied NO synthase inhibitors are not necessarily considered to act solely on the endothelium but also apparently affect nerves distributed in the adventitia, and interfere with vasodilator, nitroxidergic nerve function, thus potentiating the respose to adrenergic nerve stimulation.