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NEWS AND NOTES

Between 1916 and 1927 a worldwide epidemic of encephalitis lethargica left half a million people dead or disabled. The disease was shown to be caused by a virus; it has never been identified. Historical records suggest that there were earlier epidemics, dating back to 1580, and that between these outbreaks the disease virtually disappeared. Since 1980, however, four new cases of encephalitis lethargica have been seen at the National Hospital for Nervous Diseases in London (Brain 1987;11O:19-33). Viral cultures were negative-but the presence of oligoclonal IgG banding in the cerebrospinal fluid in three patients was in keeping with a viral aetiology.