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Association between cerebral amyloid accumulation and synaptic density in Alzheimer’s disease: A multitracer PET study

Synaptic loss is an early pathology in Alzheimer’s disease (AD) and the major structural correlate of cognitive impairment. We have recently demonstrated extensive synaptic loss in medial temporal and neocortical brain regions of participants with AD. In this study, we further investigate the association of global and local amyloid burden with synaptic density in AD using [11C]UCB‐J PET.