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Management of Undescended Testis in Children in Aba Nigeria

Introduction: The anomalies of descent of the testes are common problem in newborn male infants. An absence of the testis in the scrotal sac is defined as cryptorchidism. Ectopic testis occurs when it migrates from its usual path of descent to lie in an unusual location. it affects 2–5% of the infants at birth and 1–2% of them at 3 months of age, the incidence is even higher in preterm infants, reported at 30%. Methodology: This was a prospective cross-sectional study of all male children above 3 months of age with undescended testes who were managed by the Paediatric Surgery Unit of the Abia State University Teaching Hospital Aba from January 2016 to December 2018. Results: Thirty children aged ≤ 15 years with 40 undescended testes managed in 3 years The age at surgery was fourteen months to 15 years (median six years); five (17%) had correction before two years, 10 (33%) before five years and 15 (50%) at age ≥ 5 years. Thirty (75%) testes were palpable and ten (25%) non-palpable. Evaluation was mainly clinical. Ultrasonography was performed for six non-palpable testes but was not helpful. Laparoscopy was not used in any patient. The condition was unilateral in twenty (67%) and bilateral in ten (33%). Forty per cent of the testes were in the inguinal canal, 25% at the external ring, and 15% each at the internal ring and abdomen respectively. Six (20%) testes were macroscopically atrophic (canalicular three, abdominal two, internal ring one). Orchidopexy was performed for 34 undescended testes and orchidectomy forsix testes. Groin and scrotal haematoma developed following one orchidopexy. Following orchidopexy, two (6%) testes retracted necessitating repeat surgery. Conclusion: There is a need to educate parents, traditional birth attendants, midwives and doctors in our sub-region to ensure earlier presentation and treatment.


Introduction
Testicular maldescent is a common problem in newborn male infants. An absence of the testis in the scrotal sac is defined as cryptorchidism. The true undescended testis has arrested migration along its usual path of descent. [1] It is termed ectopic testis when it migrates from its usual path of descent to lie in an unusual location. The condition affects 2-5% of the infants at birth and 1-2% of them at 3 months of age. The incidence is even higher in preterm infants, reported at 30%. [2] Around 70% of undescended testes are palpable on clinical examination. Cryptorchidism occurs four times more commonly unilaterally than bilaterally. Most undescended testes migrate into the lower scrotum within the first 3 months of life, probably as a consequence of a postnatal surge of testosterone. Only in less than 1% of the cases does the testis remain persistently undescended by the age of 1 year. An atrophic or congenital absence of the testis may simulate a similar situation [3].
Testicular differentiation occurs during the 7th week of gestation. The testis-determining factor is the SRY gene (sexdetermining region on Ychromosome). Hormones that control male sexual differentiation include testicular androgen from Leydig cells and Mϋllerian-inhibiting substance (MIS) from the Sertoli cell. Androgens (testosterone and dihydroxytestosterone) mediate the differentiation of paired wolffian ducts into seminal vesicles, epididymis, vas deferens, and ejaculatory ducts. MIS causes degeneration of the Mϋllerian structures. [4] The testis lies dormant in the abdomen until the 28th week of gestation; thereafter, it descends into the scrotum. The multifactorial mechanism of testicular descent involves: hormonal factors: the hypothalamus-pituitary-gonadal axis; the gubernaculum and genitofemoral nerve; increased abdominal pressure; and development/maturation of the epididymis. [5] Heyns et al. of South Africa have helped elucidate the role of the gubernaculum in testicular descent. [6] There is presently no unified theory of testicular maldescent. Anomalies of the above-mentioned normal mechanism have all been implicated in the development of cryptorchism.
It has implications for fertility in later life, as germ cell counts for patients with UDT remain normal during the first 6 months of life, but then reduce along with Leydig cell numbers. It is a risk factor for testicular cancer and is also associated with complications such as testicular torsion and inguinal hernias. In infants, correct localization of the testis is essential for surgical management, because the approach may vary with the location. In adults, however, it is still important to localize the testes and identify the complications. [7] In the setting of a unilateral UDT with an associated hypospadias, intersex should be considered and a karyotype would be indicated. Where bilateral impalpable UDTs are present, endocrine work-up is required.

Methodology
A prospective study of all male children above 3 months of age with undescended testes managed by the Paediatric Surgery Unit of the Abia State University Teaching Hospital Aba from January 2016 to December 2018. A data proforma was designed to include demographic data including age at orchidopexy, clinical examination findings for the anatomical location of the testes, if in involves the right or left side, palpable or non palpable, preoperative investigations, findings at surgery involving the actual location of the testes and postoperative outcome. Statistical analysis was performed using statistical package for social sciences (version 17, SPSS Inc., Chicago, IL). A p value of ≤ 0.05 was considered significant.

Results
Thirty children aged ≤ 15 years with 40 undescended testes managed over four years period. The age at surgery was fourteen months to fifteen years (median six years). Five (17%) had correction before two years, 10 (33%) before five years and 15 (50%) at age ≥ 5 years. Thirty (75%) testes were palpable and ten (25%) non-palpable. Evaluation was mainly clinical. Ultrasonography was performed for three non-palpable testes but was not helpful. Laparoscopy was not used in any patient. The condition was unilateral in 22 (73%) and bilateral in eight (27%). Forty-five per cent of the testes were in the inguinal canal, 25% at the external ring, and 15% each at the internal ring and abdomen respectively. Six (20%) testes were macroscopically atrophic (canalicular three, abdominal two, internal ring one). Orchidopexy was performed for 34 undescended testes and orchidectomy six. Groin and scrotal haematoma developed following one orchidopexy. Following orchidopexy, two (6%) testes retracted necessitating repeat surgery.

Discussion
The management of undescended testes remains a topical issue worldwide. In this sub-region like other developing countries most boys with the condition present much later than age of two years when significant irreversible pathogenic changes have occurred in the testes. [9] The median age at presentation in this study of 5.0 years which is equivalent to the median age reported from Zaria Northern Nigeria [10] and Benin Southern Nigeria [11] of 6.0 and 8.3 years respectively but higher than 3years reported in Lagos western Nigeria [12]. This suggests increased awareness among parents and other care-givers in Lagos and also reflects the better access to healthcare resulting in earlier presentation for surgery. However, 17% were operated before the recommended age of 2 years similar to 11% in Zaria, less than 25% of the patients in Lagos and 33.3% of patients in Nnewi (South Eastern Nigeria) [13]. This is not unrelated to the late presentation of patients due to paucity of knowledge of midwives and obstetricians, collaboration between the midwives and obstetricians, through advocacy will enhance detection at birth and early referral to paediatric surgeons.
The location of the impalpable testes frequently poses a challenge. 10 (25%) testes were impalpable similar findings were earlier reported in Zaria (26%) testes were impalpable. Ultrasonography gives false negative rates as high as 50% and is believed not to be any better than careful examination by an experienced surgeon [14]. Laparoscopy has become the gold standard in preoperative localization of non-palpable undescended testes [15][16][17][18]. However, the modality is not readily available in our setting. In our environment, only ultrasound is available and it did not locate the testis in any of the three patients who had it; operative exploration of the groin and retroperitoneal space is therefore performed in all our patients with impalpable testes using the extra peritoneal approach.
Surgery for undescended testis is indicated to increase the chances of fertility, to reduce the chances of malignant degeneration or at least increases the chances of early detection of malignancy, reduce the incidence of strangulation of associated hernias and also reduce the risk of torsion. Besides this it may also prevent psychological problems associated with an empty scrotum in later life [19].
The intra-operative location of the testes corresponded with previous studies where majority being within the inguinal canal and 20% being vanished atrophic. Majority benefited from a single-stage orchidopexy while 6 (15%) required a staged treatment. Single-stage procedure was more likely in boys with palpable testes and those with testes located at the superficial inguinal ring. Single -stage procedure were also more likely in boys operated before age 3 years as previously reported by Osifo and co-workers in Benin Nigeria.
It has been shown that fertility after treatment for unilateral undescended testis is about 84%, bilateral 60% and overall 79% [20]. That report noted that fertility is poor for bilateral undescended testis if treated after 18 years. About 10% of patients with testicular cancer may give a history of cryptorchidism [20]. In the present report, fertility and cancer rate cannot be ascertained. There is a need to conduct further studies on undescended testes in our environment and also improve the facilities available for evaluation.

Conclusion
Testicular maldescent is a common presentation in paediatric urology clinic worldwide. Laparoscopy has become the gold standard in preoperative localization of nonpalpable undescended testes. Late presentation in low and middle income countries, like Nigeria still persist despite increase in the number of tertiary hospitals. There is a need to educate parents, traditional birth attendants, midwives and doctors in our sub-region to ensure earlier presentation and treatment to prevent complications such as testicular torsion, cancer and infertility.