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Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction

A green method was established for the mutual determination of the drug trifluoperazine hydrochloride (TFPH) and vanadium (V) in real samples by coupling the cloud point extraction with UV-Vis spectrophotometry. The method was based on the formation of the colored V (V)-TFPH complex in acidic medium followed the extraction of the complex by using the surfactant Triton X-114 as an extracting medium. The surfactant-rich phase extracted was dissolved in a small volume of solvent and both the drug TFPH and V (V) ions determined by spectrophotometry at maximum absorption wavelength of 476 nm. Most parameters which impact on the extraction efficiency and detection for both target analytes were optimized. Under the optimum conditions established, the preconcentration factor was found to be of 50 fold making Beer’s law obeyed in the concentration range of 2-80 μg mL-1 (r = 0.9999) for the determination of TFPH and 0.5-10 μg mL-1 (r = 0.9995) for vanadium (V), giving the detection limits of 1.21 and 0.113 μg mL-1 respectively. The mean recovery percentage of 98.94±2.19 % (in blood serum) and 99.43±1.40 (in tap water); the precision (RSD %) ranged between 0.48-3.40 % and 0.45-1.49 were obtained for TFPH and V (V) ions respectively. The proposed method was employed for the determination of TFPH in pharmaceuticals and the spiked serum samples, while a V (V) ion was determined in black pepper samples.