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Amyloid β‐peptide(25‐35) changes [Ca2+] in hippocampal neurons

INSOLUBLE aggregates of the amyloi d β-peptide (Aβ) is a major constituent of senile plaques found in brains of Alzheimer disease (AD) patients. The detrimental effects of aggregated Aβ is associated with an increased intracellular Ca2+ concentration ([Ca2+]i). We examined the effects of Aβ (25–35) on [Ca2+]i and intracellular H+ concentration ([H+]i) in single hippocampal neurons by real time fluorescence imaging using the Ca2+- and H+-specific ratio dyes, indo-1 and SNARF-1. Incubation of these cultures with Aβ (25–35) for 3–12 day s in vitro increased [Ca2+]i and [H+]i in large, NMDA-responsive neurons.