{'fraction_non_alphanumeric': 0.04035874439461883, 'fraction_numerical': 0.033311979500320305, 'mean_word_length': 5.375510204081633, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Human herpesvirus 8: Serovprevalence and correlates in tumor patients from Xinjiang, China

Human herpesvirus 8 (HHV‐8), also known as Kaposi's sarcoma‐associated herpesvirus, is etiologically associated with Kaposi's sarcoma and other lymphoproliferative diseases. Although HHV‐8 prevalence exhibits considerable variation in different geographic regions and populations, the incidence of Kaposi's sarcoma appear to increase in areas with a high prevalence rate. In this study, an enzyme‐linked immunosorbent assay based on mixed antigens of HHV‐8 ORF73, ORF65, and K8.1 in the antigenic region was established and used to determine viral prevalence estimates and risk factors associated with HHV‐8 infection. Of 482 tumor patients studied, the overall seropositivity of HHV‐8 was 25.5%. Notably, Han people, who were immigrants or descendents of immigrants from inland of China, exhibited 26.4% seropositivity. This is similar to that observed in Uygur people, a local ethnic group with a high prevalence of HHV‐8 infection and incidence of Kaposi's sarcoma. While there was no significant difference in patients with different tumors, HHV‐8 seroprevalence was higher in individuals with malignant diseases. Logistic regression analysis suggests that the age is a risk factor associated with HHV‐8 infection, with prevalence increasing from 12.5% under 20–27.5% above 50. These results suggest that unlike other parts of mainland of China, Xinjiang is an area with a high prevalence of HHV‐8 infection. J. Med. Virol. 79:161–166, 2007. © 2006 Wiley‐Liss, Inc.