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Study of the teratogenic activity of ribosomal vaccine.

The investigation on the possible teratogenic activity of a vaccinal formula of ribosomes of Klebsiella pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes A12 and Haemophilus influenzae (D 53) was carried out in three animal species: rats, mice, rabbits. The trials were performed on two generatins of rats and mice, and on one single generation of rabbits. D 53 was given in s.c. injections (6 days a week) for 8 days before mating the females, and then until the females dropped (or were sacrificed when foetuses had to be removed by Caesarean operation). The possible teratogenic or embryotoxic effects of D 53 were evaluated using the following checks: fertility rates in the mated females; rates of placenta-foetal resorptions; abnormalites in foetuses and offspring (dissection and skeletal staining). In the above experimental conditions, D 53 had no embryotoxic and teratogenic activity in the 3 animal species used.