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Minocycline treatment effects on cognition, sleep, breathing and body temperature in a model for sporadic Alzheimer's disease

Chronic inflammation plays an important role in the cascade of molecular events in the brain of patients with Alzheimer's disease (AD). Preclinical studies have shown that minocycline has a potent anti‐inflammatory effect exerted by its neuroprotective action in various neurodegenerative diseases, such as AD. Thus, we tested the hypothesis that minocycline treatment could reverse / minimize the cognitive and respiratory and sleep deficits of our sporadic AD model.