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In Vitro-in situ Correlation of Propafenone Transnasal Absorption

Purpose This paper was to investigate the correlation between in vitro and in situ methods for propafenone transnasal absorption. Methods Using excised sheep nasal mucosa permeation test in vitro and rat nasal infusion test in situ .By means of changing the medium pH,drug concentration,and forming β cyclodextrin inclusion compound,the permeability coefficient( P m),mean permeation rate,and permeation fraction were determined in vitro.Under the corresponding conditions the absorption rate costant( k ),mean absorption rate and absorption fraction in situ were also determined. Results The linear regression coefficient indicated that,under the various experimental conditions,a good in vitro in situ correlation could be confirmed. Conclusions Having an in vitro in situ correlation is useful for scientific justifying the different methods for nasal absorption studies.