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Barrier recovery rate varies time‐dependently in human skin

The recovery in cutaneous barrier functions, assessed in terms of transepidermal water loss, 1 h after tape stripping of volar forearm skin in human volunteers, was investigated at different times over the 24 h day. The barrier recovery rate was significantly lower between 20:00 h and 23:00 h than that at other time points. The skin surface temperature and the basal transepidermal water loss reached their highest values at about 03:00 h (33·6 °C and 0·30 mg cm−2 h−1), while the cortisol level in the saliva was highest at 09:00 h (7·8 pmol mL−1). These results suggest significant time‐dependent variation in cutaneous barrier repair independent of changes in skin temperature and cortisol level.