{'fraction_non_alphanumeric': 0.04225352112676056, 'fraction_numerical': 0.029577464788732393, 'mean_word_length': 4.8962655601659755, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
1172 IDIOPATHIC RECURRENT PERICARDITIS: TREATMENT WITH CHRONIC ADMINISTRATION OF IMMUNOSUPPRESSIVE AGENTS AND ASPIRIN

Idiopathic recurrent pericarditis(IRP) is characterized by resistant to therapy recurrences. We have studied the effect of chronic treatment with azathioprine and aspirin (A) on 6 patients(pt) 10-15 yr old, with severe (more than 3 relapses per yr) IRP. Antibody studies showed recent infection with Coxsakie B4 in 2 pt. No collagen disorder was found. All pt developed pericardial pain, cardiomegaly, EEG and echocardiographic abnormalities of pericarditis 1 to 3 mo after discontinuation of a 3 to 8 wk treatment with corticosteroids or A (5 pt) and A or indomethacin (1 pt). In two pt reduction of the dose of prednisone below 5 mg × 2/day resulted in recurrence of pericarditis. Administration of azathioprine (1-2 mg/kg/day) (2 pt) or A (starting dose 100 mg/kg/24hr, maintenance 70-80 mg/kg/24hr) for at least 6 mo (4 pt) resulted in disappearance of relapses till today (observation 1-6 yr). The findings indicate that: (1) the recurrences of IRP can be prevented by chronic administration of A; (2) azathioprine may be useful as an alternate drug for pt who may fail on A; (3) corticosteroids suppress the symptoms but even if chronically administerd do not prevent recurrences; and (4) the relapses of IRP result from an autoimmune mechanism, rather than from recurrences of viral infections.