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Juvenile Cataracts in a Patient with Histidinuria: Case Report

INTRODUCTION Histidinuria is a selective hyperaminoaciduria comprising histidine alone. Patients with histidinuria, however, have normal plasma amino-acid levels, including histidine. Histidinuria may be due to defective renal tubular histidine reabsorption, the so-called renal histidinuria, impaired intestinal histidine absorption, or histidinemia. Histidine plasma concentration is normal in patients with renal histidinuria, as opposed to the increased histidine plasma concentration found in patients with histidinemia. However, histidine concentration in urine is less elevated in patients with renal histidinuria than in patients with histidinemia. Renal histidinuria has been reported in patients with mental retardation1 and myoclonic seizures. Even though ocular findings such as congenital ocular fibrosis have been reported in patients with histidinemia,2 to our knowledge, there are no reports about ocular findings in patients with renal histidinuria. Multiple metabolic etiologies have been associated to juvenile cataracts.3–5 We report on a patient with histidinuria who had juvenile cataracts and no other central nervous system findings.