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[Biological activity of C-ring-oxidized estrogens. The effect of 9 alpha-hydroxy-11 beta-nitroxy estrone and its acetate on the reproductive tract of male and female rats].

A study of the effects of 9 alpha-hydroxy-11 beta-nitroxy analogs of estrone and its acetate has shown that the insertion of 9,11-hydroxynitrate grouping in the estrogen molecule increased considerably antigonadotropic activity, determined by the inhibiting testicular growth effect, and the duration of uterotropic action in administration per os as compared to similar indices in subcutaneous injections. Dissociation of antigonadotropic and uterotropic activity was also noted in injection of the analogs in the stomach as a result of an increasing antigonadotropic effect. Experiments were performed on immature male and female rats.