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Evaluation of liquid‐based cytology in cervical screening of high‐risk populations: a split study of colposcopy and genito‐urinary medicine populations

A split study evaluated the ThinPrep® PapTest™ (TP; Cytyc Corp., Boxborough, MA) compared with current methodologies of cervical cytology in two high‐risk cohorts. One thousand, three hundred cases from a colposcopy clinic and a genito‐urinary medicine outpatient clinic were examined. The TP reported increased detection of all grades of dyskaryosis (mild, moderate and severe; + 4.5%) and a decrease in borderline and unsuitable cases (− 4.9%). Four cases of high‐grade dyskaryosis (moderate or severe) were detected only using the TP, while an additional four cases classified as high‐grade dyskaryosis with the TP were reported as borderline by our conventional methods. The split‐study finding of increased sensitivity with the TP provides for improved clinical management of patients in our high‐risk cohorts.