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3‐D spheroid culture of bone marrow mesenchymal stem cell of rhesus monkey with improved multi‐differentiation potential to epithelial progenitors and neuron in vitro

Background:  Bone mesenchymal stem cells are an attractive source of cells with potential applications in ocular regenerative medicine. However, the low differentiation efficiency in the traditional two‐dimensional (2‐D) culture system limits their application for clinical therapy. Here, we describe a simple and innovative 3‐D culture environment and assess the potential for bone mesenchymal stem cells to differentiate into a variety of cell types in the 3‐D system.