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Implantable neural spike detection using lifting-based stationary wavelet transform

Spike detection from high data rate neural recordings is desired to ease the bandwidth bottleneck of bio-telemetry. An appropriate spike detection method should be able to detect spikes under low signal-to-noise ratio (SNR) while meeting the power and area constraints of implantation. This paper introduces a spike detection system utilizing lifting-based stationary wavelet transform (SWT) that decomposes neural signals into 2 levels using ‘symmlet2’ wavelet basis. This approach enables accurate spike detection down to an SNR of only 2. The lifting-based SWT architecture permits a hardware implementation consuming only 6.6 μW power and 0.07mm2 area for 32 channels with 3.2 MHz master clock.