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Pleomorphic xanthoastrocytoma: an immunohistochemical study of three cases

Pleomorphic xanthoastrocytoma is a rare brain tumour, occurring in young subjects and usually having a favourable prognosis’. Histologically, a proliferation of spindle cells, monoand multinucleated giant cells containing lipid droplets, and the absence of necrosis and mitoses are characteristic features’. Immunoreactivity for glial fibrillary acid protein (GFAP) on tumour cells suggested an origin from subpial astrocytes’ . Controversy, however, exists about the neoplastic or the reactive nature of the GFAP positive cells’. We investigated the morphological and immunophenotypical features of three cases of pleomorphic xanthoastrocytoma with the aim of elucidating the cell composition and nature of this tumour. The main clinical data are reported in Table 1. All three patients presented with non-specific neurological symptoms, which promptly disappeared after surgical resection.