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Respiratory impedance response to a deep inhalation in children with history of cough or asthma

The aim of this study was to describe the change in respiratory impedance induced by a deep inhalation (DI) in children who developed a positive response to inhalation of methacholine (Mch). Eighteen children aged 4.5–12.5 years, presenting with chronic cough or doctor‐diagnosed asthma, were studied at baseline after inhalation of Mch and after inhalation of a bronchodilator. Respiratory resistance (Rrs) and reactance (Xrs) were measured by the forced oscillation technique, varying transrespiratory pressure at 12 Hz around the head. The tidal flow (V′) and volume (V) dependence of Rrs before and after the DI was characterized according to the equation Rrs = K1 + K2 · |V′| + K3 · V.