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A classic case of sensitization to DD‐95

In the last 3 years, we have seen 3 patients with positive patch test reactions to palladium. However, all these palladium-sensitive patients also reacted to other metals (tin; nickel and copper; and cobalt only, without nickel). Combined sensitization to palladium with metals other than nickel or cobalt has been reported only once, with an allergic patch test reaction to metallic mercury (4). Further studies are needed to define the pathogenetic mechanisms and the clinical relevance of the unusual combined reactions of palladium.