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Aromatization of epitestosterone by human placenta.

Homogenates of human term placenta incubated with epitestosterone 1,2-3H and NADPH yielded 17α-estradiol as the major product of aromatization. This suggests that 17α-estradiol is formed in the human placenta daring pregnancy and agrees with the reported excretion of 17α-estradiol in the bile and of 11-dehydro-17α-estradiol in the urine of pregnant women. (Endocrinology 86: 912, 1970)