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Molecular Dissection of α‐ and Dense‐Core Granule Secretion of Platelets

Abstract: Upon activation, platelets release many active substances stored in α‐ and dense‐core granules. However, the molecular mechanisms governing the regulated exocytosis are not yet fully understood. We have established an assay system using streptolysin‐O‐permeabilized platelets to analyze the Ca2+‐induced secretions of von Willebrand factor stored in α‐granules and [3H]5‐hydroxytryptamine (5‐HT) in dense‐core granules. Using the assay, we found that small GTPase Rab4 regulates α‐, but not dense‐core, granule secretion in platelets. Furthermore, we purified a cytosolic essential protein and currently are analyzing its function.