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Suppression of Oral Tolerance by Lactococcus lactis in Mice

Although oral ovabumin (OVA) administration suppressed the antibody (Ab) response in OVA-immunized mice, Lactococcus lactis increased OVA-specific IgG2a in these mice. L. lactis increased the casein-specific IgG level in NC/Nga mice fed on a casein diet. The percentage of CD4+CD25+ cells was increased in DO11.10 mice orally given OVA, but this increase of CD4+CD25+ cells were suppressed in L. lactis-fed DO11.10 mice.