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A Dual Mode Neural Signal Recording System for synchronous neuroeletrical and neurochemical detection

This paper presents a 64-channel Dual Mode Neural Signal Recording System (DMNSRS) for detection of neuroeletrical and neurochemical signals. The DMNSRS comprises neurochemical recording module with current resolution of 1 pA and neuroelectricity recording module with voltage resolution of 0.3 μV. The two modules can work synchronously without mutual interference. In a global cerebral ischemia experiment, using Multi-Electrode Arrays (MEA) as neurobiological electrode and a single-walled carbon nanotube (SWNT)-modified glassy carbon electrode as neurochemical working electrode, the neuroelectrical and neurochemical signals are synchronously recorded by the DMNSRS in the Sprague-Dawley (SD) rat cortex.