{'fraction_non_alphanumeric': 0.028700906344410877, 'fraction_numerical': 0.012084592145015106, 'mean_word_length': 5.389067524115756, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 1, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
The Efficacy and Safety of using Nebulized Antibiotics in Treatment of Ventilator-Associated Pneumonia

Development of ventilatorassociated pneumonia [VAP] is associated with high morbidity and mortality rates. VAP mortality ranges between 5.8% and 27% [1]. Routine administration of intravenous antibiotics does not reach a bactericidal concentration in lung tissues. intravenous antibiotics are mainly detected in respiratory segments of lungs, but not in sputum [2].This study was conducted on 60 patients who were admitted to critical care department at Benha University Hospital and diagnosed with Ventilator Associated Pneumonia [VAP]. patients were divided into two groups: Group A included 30 patients have received only systemic antibiotics and Group B included 30 patients have received systemic and nebulized antibiotics. In this study the clearance of organism, resistance, superinfection and combined [resistance and super infection] were significantly different in group A vs.B .There was significant decrease regarding creatinine level in group B vs. A .There were significant reduction in duration of MV and length of ICU stay in group B vs. A.Nebulized Amikacin plus ceftazidime are effective in the treatment of VAP. 1.Introduction The incidence of VAP is approximately 10%-30% of patients required mechanical ventilation for more than 48 h. This incidence depends on the type of population studied, risk factors, and the quality of preventive protocols implemented [3] . The mortality rate for VAP exceeds that of death due to infections associated with central venous catheters, severe sepsis, and respiratory infections in non-intubated patients [4]. The US National Healthcare Safety Network Centers for Disease Control and prevention have an algorithm for defining healthcare-associated pneumonia Table (1). 1.1Radiological signs Two serial chest x-rays with one or more of the following:– New or progressive and persistent infiltrate – Cavitation – Consolidation