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Amelioration of dystrophic epidermolysis bullosa pruriginosa symptoms with dupilumab: A case report

Dear Editor, A 10-year-old female developed papules and rough nodules on her trunk and limbs with intense itching that had been present for 6 years. The lesions originally appeared over her right leg and consisted of scattered dark red papules and nodules accompanied with itching. Subsequently, the lesions gradually extended to both upper limbs and trunk. Diagnoses from the various clinics visited by the patient included eczema, dermatitis, and prurigo nodularis with treatments consisting of systemic and topical corticosteroids and antihistamines producing no or only transient improvements. On physical examination, dark red flat papules, confluent plaques were present on her back and limbs, with lesions being more pronounced bilaterally on the dorsum of her hand and anterior tibial area (Figure 1A,C). Results of laboratory assays, including routine blood analysis along with hepatic and renal functions were normal. Histopathological results revealed a subepidermal bulla containing