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Translocations involving 9p and/or 12p in acute lymphoblastic leukemia

Fifteen cases of acute lymphoblastic leukemia (ALL) with translocations involving 9p and/or 12p are described. Four children, three males and one female, age range 1–8 yrs, had translocations involving 9p but not 12p. Of these, three had B‐lineage ALL and one had biphenotypic T‐ALL/acute myeloid leukemia. Six patients, three males and three females, age range 1–49 yrs, had translocations involving 12p but not 9p. Five had B‐lineage ALL and one had T‐ALL. One patient had dic(7;12)(p11;p11), confirming that this previously reported translocation is nonrandom in ALL. One patient had t(2;12)(q14;p13), and it is suggested that this may also be a new nonrandom abnormality. Five patients, four males and one female, age range 11–21 yrs, had common ALL and dic(9; 12). The dic(9; 12) appears to confer a better prognosis than do other translocations involving 9p or 12p.