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Applications of surface-enhanced Raman spectroscopy (SERS) for biosensing: an analysis of reproducible commercially available substrates

The rapid and accurate determination of bacterial spores in sterile environments (i.e., food preparation areas and hospitals) is of great importance in the minimization of bacteria-driven illnesses. Surface- Enhanced-Raman-Scattering (SERS) is potentially a very sensitive spectroscopic technique for the detection of biological threat agents. SERS can be made a more robust and attractive spectroscopic technique for biological threat agent sensing by developing high sensitivity, high reproducibility SERS-active substrates. The maturation of Si-based semiconductor fabrication techniques has facilitated the development and marketing of highly reproducible and sensitive SERS-active substrates. KlariteTM SERS-active substrates (Mesophotonics LTD) have been analyzed for utility in the potential identification of biological threat agents. Concurrently, we have investigated prototype SERS- active substrates under development by Nanospectra Biosciences, Inc. Substrate spatial reproducibility and substrate-to-substrate reproducibility will be discussed.