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Spontaneous regression of a childhood tumour with anaplastic histological features

An 8-year-old girl presented with a 6-week history of a solitary erythematous skin lesion adjacent to the left areola. It had started as an itchy papule suspected to be an insect bite, and had progressed rapidly over 3 weeks. The girl was otherwise healthy. On physical examination, a area of erythematous induration with ulceration, 20 · 10 mm in size, was seen on the skin of the chest and focally reaching the left areola (Fig. 1a). It failed to respond to courses of antibiotics and topical hydrocortisone acetate and fusidic acid treatment, and a superficial pyoderma gangrenosum was suspected. An incisional biopsy was taken. Shortly afterwards, the lesion started regressing and healed spontaneously (Fig. 1b). No additional skin lesions, nodal or other extracutaneous disease were detected during staging investigations.