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Anti-ulcer investigation of the different extracts of bark of Bauhinia variegata Linn (Family- Caesalpiniaceae) by pyloric ligation & aspirin plus pyloric ligation model

Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5-10% of people during their life. In recent years, abundant work has been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. Here, present study was carried out to investigate antiulcer activity of petreolium-ether & aqueous extracts of bark of Bauhinia variegata Linn (Family: Caesalpiniaceae) in pylorus ligation and Aspirin plus pylorus ligation induced ulceration in albino rats. Two dose levels 200mg and 400mg/kg were selected for the study. In both ulcer models, various parameters were studied viz. gastric volume, pH, total acidity, free acidity, and ulcer index. Ulcer index and percentage inhibition of ulceration was determined. Ranitidine 50 mg/kg was used as standard drug.