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A preclinical model to investigate the role of surgically‐induced inflammation in tumor responses to intraoperative photodynamic therapy

Inflammation is a well‐known consequence of surgery. Although surgical debulking of tumor is beneficial to patients, the onset of inflammation in injured tissue may impede the success of adjuvant therapies. One marker for postoperative inflammation is IL‐6, which is released as a consequence of surgical injuries. IL‐6 is predictive of response to many cancer therapies, and it is linked to various molecular and cellular resistance mechanisms. The purpose of this study was to establish a murine model by which therapeutic responses to photodynamic therapy (PDT) can be studied in the context of surgical inflammation.