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233. Evaluation of an Antimicrobial Time-Out on Antimicrobial Utilization at a Large Health System

Abstract Background Infectious Diseases Society of America and Society for Healthcare Epidemiology Guidelines for Implementing an Antibiotic Stewardship Program (ASP) and the CDC Core Elements of Hospital ASP include antimicrobial time-outs (ATO) as an example of a recommended action. There are limited data evaluating the impact of ATOs on antimicrobial use. Cleveland Clinic Health-System (CCHS) implemented a 72-hour ATO for antimicrobials with an empiric indication and no stop date within the electronic health record. This study aimed to assess the effect of an ATO on antimicrobial utilization. Methods Retrospective, quasi-experimental study of patients between October 1–December 31, 2016 and 2017 who received at least one systemic antimicrobial agent while admitted to a US-based CCHS hospital. Primary objective was to compare the days of therapy (DOT) per 1,000 patient-days of broad-spectrum agents before and after ATO implementation. Secondary objectives included comparing indications for use, actions taken as a result of the ATO, and rate of Clostridium difficile. Antimicrobial groupings per National Healthcare Safety Network AUR Module. Results In 4Q2016, there were 75,982 antimicrobial orders in 31,945 encounters, of which 5,029 encounters had an empiric antimicrobial active at 72 hours. In 4Q2017, there were 78,418 antimicrobial orders in 33,378 encounters, which led to 38,129 ATOs in 6,138 encounters. Mean duration of therapy was 71 hours in 4Q2016 vs. 62 hours in 4Q2017, P < 0.05 (Figure 1). DOT/1,000 patient-days did not differ (Figure 2). Orders with the indication of pathogen directed did not change (14.1% vs. 14.4%; P = 0.11). Of 16,009 ATOs acknowledged by clinicians, 2,195 (14%) prompted antimicrobial discontinuation, while 684 alerts (4%) prompted de-escalation. There was no difference in encounters with positive C. difficile PCR, 123 (2.4%) vs. 152 (2.5%). Conclusion Implementation of an ATO for all antimicrobials within an electronic health record decreased duration of therapy but not DOT/1,000 patient-days. Further study is needed to define optimal ATO characteristics (targeted vs. all antimicrobials, 48 vs. 72 hours, etc.) and potential impact on utilization and appropriate antimicrobial usage. Figure 1. Figure 2. Disclosures All authors: No reported disclosures.