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The Role of MCA in Dermatology: Monoclonal Antibodies in Cutaneous Immunohistochemistry

Since the first demonstration of antibodies in sera of pemphigus patients by immunofluorescence in 1964, dermatology has become one of the leading clinical specialities applying immunohistochemical methods for both research and current diagnosis. The first step has been the study of Ig deposits in autoimmune or other immunologically related skin diseases such as, for example, pemphigus, pemphigoid, D.H. and L.E.