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The changes of glycosaminoglycan in the growth of urethane-induced mouse mammary tumors.

The changes of glycosaminoglycan (GAG) in the growth of urethane-induced mammary tumors in BALB/c mice were investigated. The artificial mammary tumor was chemically induced by urethane. Successive homo-transplantations of this artificial mammary tumor were successfully achieved at the rate of 100%. Histologically, this artificially induced transplantable mammary tumor (MC) line maintained the characteristics of adenoacanthoma of primary tumors in each successive generation. MC in each generation showed a logarithmic growth beginning from about the 5th day after transplantation, and their growth became slow about the 30th day. Histochemically, GAG components in MC were distributed into the interstitial tissue and into some of the squamous metaplastic epithelial cell layers. Biochemically, GAG components consisted primarily of hyaluronic acid (HA), dermatan sulfate (DS) and chondroitin sulfate (ChS), but there were also small amounts of components which could not be identified. The HA content of MC increased during the logarithmic growth phase and decreased during the stationary phase. However, DS and ChS contents increased during the stationary phase of MC. These increases, histologically, corresponded with propagations in fibrous interstitial tissue. In the final analysis, it is surmised that HA is involved in the take and growth of MC (adenoacanthoma) in mice, while DS and/or ChS are involved in the proliferation of the fibrous interstitial tissue cells of the tumor.