{'fraction_non_alphanumeric': 0.019727891156462583, 'fraction_numerical': 0.0020408163265306124, 'mean_word_length': 5.313304721030043, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Regulation of homocytotropic antibody formation in the rat. V, Cell cooperation in the anti-hapten homocytotropic antibody response.

Anti-hapten homocytotropic antibody (HTA) formation was induced in rats by two succeeding injections of dinitrophenylated Ascaris extracts (DNP-As) with a 5-day interval by the use of Bordetella pertussis vaccine as an adjuvant. The suppressive activity of anti-hapten and anti-carrier antibodies on the HTA formation was tested by immunizing rats with various antigen-antibody precipitates in which hapten, carrier or both were covered by an excess of rabbit antibodies directed to the respective determinants. It was found that a covering of carrier determinants in the first injection on day 0 suppressed the anti-hapten HTA response, whereas the covering of haptenic determinants was rather enhancing. On the other hand, a covering of haptenic determinants by anti-hapten antibodies in the second injection was greatly suppressive, while a covering of carrier determinants was ineffective. It was also found that the first injection of DNP-As on day 0 could be replaced by injection of the unconjugated carrier to prepare animals for the subsequent induction of the antihapten HTA response following a second single injection of the hapten-carrier conjugate. The results indicate that carrier determinants are first recognized by carrierspecific cells which interact with hapten-specific cells to induce formation of antihapten HTA.