{'fraction_non_alphanumeric': 0.03363700070077085, 'fraction_numerical': 0.007708479327259986, 'mean_word_length': 5.102564102564102, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 3, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Tracing the Indian Population Ancestry by cis-linked Mutations in HBB Gene

Background Human left their genetic footprints during the time of migration throughout the different countries all over the world. Human evolution was studied through various markers. India is a country of rich heritage and cultural diversity. The modern Indian population is derived from two ancestral groups, viz.-Ancestral North Indians (ANI) and Ancestral South Indians (ASI). Aim Finding out the migratory route of the modern Indian population by studying ‘cis’ acting mutations of human beta-globin (HBB) genes. Subjects and methods A total of 120 thalassemia subjects were enrolled. DNA sequencing was done for mutation detection in the HBB gene. Some previous literature reviews were gone through for tracing mutations, all over the world and in the Indian subcontinent. Results Nine thalassemia patients were found where HBB:c.92G>C and HBB:c.-92C>G mutations co-exist together in ‘cis’ condition. Only one patient had HBB:c.51delC and HBB:c.33C>A. The pedigree analysis confirmed the presence of these mutations in ‘cis’ condition and vertical transmission from one generation to the next. Literature reviews also reassure the co-existence of these mutations from different countries. Conclusion The co-existence of these ‘cis’ acting mutations helps to point out the possible migratory route of ANI population after venturing out of Africa.