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To sprout or "Notch" to sprout?

In this issue of Blood , Zheng and colleagues demonstrate that the Notch signaling pathway is active in lymphatic endothelial cells and that inhibition of Notch signaling, in concert with vascular endothelial growth factor (VEGF) stimulation, promotes lymphatic endothelial cell sprouting. 1 This work suggests that Notch signaling plays a key role in regulating the switch between lymphatic endothelial cell quiescence and sprouting, akin to the role played by Notch signaling during angiogenic sprouting of the blood vasculature, and has important implications for therapeutic targeting of the Notch pathway as a treatment for vascular disorders and cancer.