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Major depression in Parkinson's disease.

Nevertheless, the frequency of major depression in PD found by Veiga et al. was still impressively high.The frequency of depression may be influenced by several characteristics of the study, such as study design, proportion of men/women, and inclusion/exclusion of demented patients. In addition, as already pointed out by the authors, we also believe that the setting of the study (tertiary center) and especially the inclusive approach are primarily responsible for this high frequency of major depression. Although the DSM-IV criteria may be appropriate to diagnose depression in PD, the inclusive approach still lacks validation. It is also worth mentioning that the mean score in the