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[Mechanism of the radiation effect at the level of the supramolecular structures of eukaryotic DNA].

The methods of viscosimetry and light scattering were used to study the radiosensitivity of the supramolecular DNA (SM DNA) structure in vivo. Irreversible lesions were found in SM DNA 2 min after gamma-irradiation of rats with a dose of 10 Gy. They were associated with the damage to the RNA-lipoprotein component (a linker) and with the dissociation of SM DNA to fragments of different molecular weight, that is, 109 +/- 25 X 10(6), 51 +/- 15 X 10(6), and 47 +/- 21 X 10(6) D for liver, spleen, and thymus, respectively, which correlated with the radiosensitivity of these organs.