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The implications of non‐invasive prenatal testing failures: a review of an under‐discussed phenomenon

Non‐invasive prenatal testing (NIPT) using cell‐free DNA in maternal blood is a relatively new screening modality for the common trisomies of chromosomes 21, 18 and 13 and sex chromosome aneuploidies. For some patients, however, results are not reported because of laboratory technical issues such as low fetal fraction and sequencing failures. In this review, the clinical implications of NIPT test failures are discussed.