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E PROSTAGLANDINS IN AMNIOTIC FLUID DURING LATE PREGNANCY AND LABOUR

Concentrations of prostaglandins e1 and E2 (PGE1 and PGE2) have been measured by gas liquid chromatography with electron‐capture detection, in samples of amniotic fluid from 49 patients with normal pregnancies and one patient with a pregnancy complicated by anencephaly. In 10 of 12 samples taken before the onset of clinical labour, PGE2 levels were below 0.5 ng. per ml. In 37 samples, obtained from patients in labour, PGE2 concentrations varied from 1 .2 to 17.0 ng. per ml. PGE2 concentrations increased significantly (p<0.001) with advancing cervical dilatation. No PGE1 (less than 0.5 ng. per ml.) was found in any sample investigated. Levels of PGE2 in oxytocin‐induced or spontaneous labour were not statistically different. No PGE2 was found in the late first stage labour in one patient, in whom pregnancy was complicated by anencephaly.