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Bacteriophage Therapy for Control of Necrotic Enteritis of Broiler Chickens Experimentally Infected With Clostridium perfringens

Important Findings The two studies described in this article show that there is potential benefit in using a bacteriophage cocktail to control necrotic enteritis (NE) in broiler chickens. Our current data indicate that the multivalent, Clostridium perfringens–specific, bacteriophage preparation INT-401 significantly reduces NE-associated mortality of, and significantly improves weight gain and feed conversion ratio (FCR) in, broiler chickens infected with C. perfringens. Additionally, it is shown that the bacteriophage preparation can be successfully administered to broilers via either the feed or drinking water in a floor-pen rearing situation. Use of a bacteriophage preparation targeted at C. perfringens may provide a replacement for, or an adjunct to, use of antibiotics for control of NE.