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Zafirlukast has no beneficial effects in the treatment of chronic urticaria

Background Leukotriene receptor antagonists have shown some efficacy in the treatment of asthma. Injection of LTC4, LTD4 and LTE4 into the skin leads to a weal‐and‐flare reaction, suggesting an involvement of leukotrienes in the pathogenesis of urticaria. Indeed, various reports have indicated a beneficial effect for leukotriene receptor antagonists in patients with chronic urticaria.