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Current status of research on transgenic animal models for Alzheimer ’ s disease brain tissue of the Alzheimer patients tends to shrivel like a dried walnut as the patients ’ behavior worsens ( Desikan

Each and every pathological visible effect is mostly due to molecular or biochemical reactions on cellular and intracellular level. This was the reason why in the last decade many incurable or poorly understood diseases were at least partially described. This is also the Alzheimer’s disease case, extremely aggressive and highly unpredictable. Many studies showed various conclusions used in further research to develop treatments and biochemical therapies in order to slow the degenerative effects or to eradicate the means and motives of this disease. Generally, in order to cure a certain disease, one must surely know the mechanisms of actions involved in its pathology and the start point, also very important. In Alzheimer’s disease, there has been studied an entire cohort of hypothesis and by using animal models the researchers reached possible cause variants. Because of the unknown idiopathic Alzheimer’s disease etiology, animal models were based on genetic mutations associated with familial Alzheimer, supposing that following events are identical. These genetic models are highly valuable to elucidate the molecular mechanisms which determine the disease’s progression, although no animal model can replicate the entire disease symptomatology. For this reason, every animal model type can be used to study one aspect of the disease. For example, transgenic mice overexpressing APP gene exhibit a similar pathology as humans. Age dependence and beta-amyloid accumulation speed was determined also by using transgenic mice. Beta-amyloid plaques discovered in transgenic mice brains were extremely similar to humans ones. Using the same manner of research, it was found a link between beta-amyloid plaques and alfa-synuclein. Plaques coloring method was also developed by various coloring techniques used on histological transgenic mice brain tissue smears. Alzheimer’s disease pathology was well studied using transgenic animal models in order to characterize the molecular deficiencies observed in humans. Because of the incapacity of study on human subjects due to ethical reasons and specific human characteristics, several animal models have been developed, which facilitated the study Alzheimer’s disease features one at a time.