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Magnetic Nanoparticles for Therapy and Diagnostics

The research and utilization of the magnetic nanoparticles in, e.g., biology and medicine have been preferentially oriented on magnetite Fe<sub>3</sub>O<sub>4</sub> and maghemite γ-Fe<sub>2</sub>O<sub>3</sub>. The complex oxides allow a better control of the magnetic properties in a desirable way. We demonstrate this approach on an example of the La<sub>1-x</sub>Sr<sub>x</sub>MnO<sub>3</sub> perovskites from the point of view of their use in self-controlled magnetic fluid hyperthermia and increase of contrast in magnetic resonance imaging. With materials possessing suitable values of transition temperature <i>T</i><sub>C</sub>, coercivity and magnetization, the heating power generated by the nanoparticles was estimated by two independent methods and they were finally employed in vitro and in vivo hyperthermia experiments.