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Vascular stiffness in familial hypercholesterolaemia is associated with C‐reactive protein and cholesterol burden

Background  Familial hypercholesterolaemia (FH) is characterized by very high serum cholesterol and premature coronary atherosclerosis. Arterial stiffness and atherosclerosis are two major underlying pathophysiologies of arterial disease that are predictive of future cardiovascular events. The aims of this study were to quantify atherosclerosis and arterial stiffness and to evaluate their relationship with high sensitive C‐reactive protein (hs‐CRP) and the level of exposure to high serum cholesterol in FH patients.