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Red cell genotyping: Real world use

In this issue of Transfusion Medicine Hui et al describe the experiences at two London trusts (ICHNT, LNWH) of obtaining an extended red cell antigen profile by genotype for patients with sickle cell disease (SCD), with a focus on RH variants and associated alloimmunization. 1 Overall, approximately half of the patients had extended red cell genotypes performed and 20% had RH variants. A small proportion of these patients (10%) had antibodies associated with the RH variant identified. Their work highlights several questions for haematologists and transfusion medicine specialists who care for patients with SCD. and choice for alloimmunized and patients with RH