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Changes in vesicular membrane ESR spin label parameters upon isotope solvent substitution.

Isotope solvent substitution, most frequently D 2 0 for FLO, has widely been used to investigate mechanisms of water interaction with biological objects, and to reveal the role of water in a number of biochemical and physiological processes. Numerous works have suggested changes occurring in biological membranes and their properties upon isotope exchange, involving passive and active trans­ port of ions through biological membranes (Kaminer and Kimura 1972; Gilles­ pie 1975). Kremlev and Lobyshev (1978) have shown that the substitution of heavy for normal water resulted in a substantial increase in the stability of artificial bilayer membranes with a decrease of the kinetic rate of incorporation of polyaminoacids which modify membrane electrical conductance. This can be explained by the formation of a much firmer net of deuterium hydrogen bonds, including water molecules localized in the phospholipid polar groups region. This should finally result in changes in dynamic characteristics of the bilayer. The properties of a bilayer are directly related to the properties of protein structures in the membranes which form channels of various types. Prompted by the lack of reports of experimental results concerning this problem, we started studying dynamic characteristics of cardiolipin and cholesterol-supple­ mented egg lecithin vesicular membranes in normal and heavy water, using the method of ESR spin probes.