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On the association between photodynamic and enzyme-inducing activities on polycyclic compounds.

The photodynamic activities of 240 polycyclic compounds, determined with Paramecium caudatum , were compared with their in vivo induction of zoxazolamine hydroxylase activity in rats. A highly significant association was demonstrated between photodynamic and enzyme-inducing activities. Compounds with high photodynamic activity had 10 times greater odds of inducing hydroxylase activity than compounds with low photodynamic activity. Properties associated with enzyme induction appear necessary but not sufficient for high photodynamic activity.