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131 ANTIADRENAL AND ANTIPITUITARY CELLS ANTIBODIES IN CHILDREN WITH PRIMARY ADERNAL INSUFFICIENCY (PAI)

The detection of antiadrenal, antigonadotropic and corticotropic cells' antibodies by indirect immunofluorescence, was performed in 14 children with PAI : 4 with congenital adrenal hypoplasia (CAh) including 2 adolescents with documented LH deficiency, 6 with autoimmune syndrome and 4 with adrenoleucodystrophy. High titers of antiadrenal antibodies were found in the 6 patients with autoimmune associations while absent in the others. Anticorticotropic (8/14) and gonadotropic (10/14) cells antibodies were present in the 3 categories of patients, and antigonadotropic cells antibodies were constantly present at high titers in cases of CAh.In conclusion 1) antiadrenal antibodies are specific of autoimmune PAI, 2) antipituitary immunity is frequent in children with PAI of various cases, 3) in patients with CAh, a relationship between high titers of antigonadotropic cells antibodies and the development of a LH deficiency can be discussed.