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HEMATOLOGICAL BIOMARKERS ASSOCIATED WITH INFLAMMATION AND CARDIOVASCULAR RISK IN PSORIASIS SEVERITY

Objective: Psoriasis is a chronic inflammatory disease charactered by abnormal proliferation of keratinocytes and infiltration of immune cells and is associated with increased cardiovascular risk. Psoriasis Area and Severity Index (PASI) is a clinical tool used to assess the severity of psoriasis. Circulating biomarkers, such as those of complete blood count (CBC) derived ratios such as platelet-lymphocyte (PLR) and lymphocyte-monocyte (LMR), have been shown to be associated with autoimmune diseases and have been identified as indicators of systemic inflammation surrogate biomarkers. This study aims to evaluate the impact of CBC biomarkers on psoriasis and their clinical severity (PASI). Design and method: Sixty-three psoriasis patients with a mean age of 52.50 ± 12.81 years. Sociodemographic, hemodynamic and routine blood laboratory data were collected. Patients were stratified based on PASI: < 5 (Group I) and > or equal to 5 (Group II). Biochemical parameters were determined in serum according to standardized methods. For statistical analysis SPSS program was used and a significant value for p < 0.05. Results: Compared patients between the group I and II it were observed higher levels in this last group of: hemoglobin (p = 0.049), mean corpuscular hemoglobin concentration (p = 0.027), leukocytes (p = 0.012), neutrophils (p = 0.006), erythrocyte sedimentation rate (p = 0.032), Gamma-glutamyltransferase (p < 0.001), alkaline fosfatase (p = 0.046), triglicerides (p = 0.038), PLR (p = 0.012) and lower values of: ymphocytes (p = 0.010), LMR (p = 0.018), chloride (p = 0.035), cholesterol-HDL (p = 0.003) and tumour Necrosis Factor alpha (p = 0.030). Conclusions: Routine CBC, derived indices and biochemical parameters related to inflammation and cardiovascular risk appear to be inexpensive and easily accessible biomarkers to psoriasis severity.