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Molecular Aspects of Resistance to Antibiotic of Community Escherichia coli Uropathogenic Strains in Bamako

The aim of this study was to determine the resistance phenotypes and genes involved in antibiotic resistance of community uropathogenic E. coli strains in Bamako. E. coli strains were isolated from the urine from September 2011 to June 2012 of external patients who were seen in specialized department of CHU, research of resistance support (integrons and resistance genes) were performed at the Experimental Bacteriology Unit at the Institute Pasteur of Dakar (Senegal). During the study, we have isolated 29 strains of E. coli, the majority produced betalactamase extended-spectrum (55.17%). The resistance was high to amoxicillin, third generation cephalosporins including ESBL (55%), sulfamethoxazoletrimethoprim and fluoroquinolones. Genetic supports detected were blaTEM1 (72%), blaSHV1 (38%), blaOXA1 (52%), blaCTXM1 et blaCMY1 (44%), blaCTXM9 (13%), QnrB (4%) et QnrS (88%). The majority of ESBL-producing strains presented the QnrS gene (88%). Integrons Class 1 (intl 1) were found in 31% of strains and class 2 integrons (intl 2) at 7%. No class 3 integron was detected.The QnrB gene was found in only a single strain. No strain has presented the QnrA gene. This growing increase in resistance to various antibiotics, confirmed by the presence of plasmid genes dictate the strengthening of the surveillance of resistance in our country, through good practice in antibiotic therapy in the hospital and in the community. We must establish a monitoring network antibiotic involving private practice physicians, hospitals and laboratories.