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Human red cell antigens

The In(Lu) gene, which inhibits the expression of Lutheran blood group antigens by red cells (RBCs), also down‐regulates the expression of an 80‐kD glycoprotein, In(Lu)‐related p80, by both RBCs and a subset of white cells. This study examined the expression of multiple‐RBC p80 epitopes by autosomal and X‐linked recessive‐type Lu(a−b−) RBCs in order to explore the relationship, if any, between expression of In(Lu)‐ related p80 and Lutheran antigens. Both autosomal and X‐linked types of recessive Lu(a+b−) RBCs expressed near‐normal to increased amounts of p80 antigens, as measured by radioimmunoassay. P80 from both types of recessive Lu(a−b−) RBCs had apparently normal molecular weight in denaturing polyacrylamide gels and showed normal sensitivity to digestion by trypsin and chymotrypsin. Thus, the absence of Lutheran antigens on recessive‐type Lu(a−b−) RBCs is not associated with decreased or absent p80 antigens. Furthermore, the XS2 gene probably does not act via a mechanism similar to that of the In(Lu) gene, since the expression of p80 remains undiminished in X‐linked recessive‐type Lu(a−b−) RBCs.