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(Invited) Integrated Perfusion Culture Microchamber Array Chip for High-Throughput Drug Dose Response Assay

We report a microplate-sized integrated perfusion culture microchamber array chip for high throughput drug dose response assays. The microchamber array chip was equipped with a pressure-driven interface, in which solutions were delivered into the microfluidic network by pneumatic pressure, and with a serial dilution microfluidic network, which generated a logarithmic concentration profile. The microchamber array chip is composed of an array of 384 microchambers for parallel quadruplicate assays using 12 drugs with 8 varying concentrations. The perfusion culture microchamber array chip, with its simple interface and well-designed microfluidic network, will likely become an advantageous platform for future cell-based assay.