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Moderately‐Fermentable Potato Fiber Attenuates Symptoms During Experimental Colitis

Potato fiber (PF), a co‐product of potato starch isolation, is a moderately‐fermentable dietary fiber that was evaluated for its efficacy in attenuating the acute inflammatory response in a dextran sodium sulfate (DSS)‐induced colitis mouse model. We hypothesized that PF would attenuate the inflammatory response through production of short‐chain fatty acids (SCFA). Male C57Bl/6J mice (N=67) were randomized based on initial body weight to diets containing either cellulose (CELL; N=34) or PF (N=33) for the 22 d feeding study. On study d 14, mice were provided either distilled water or 2% (wt/vol) DSS in drinking water for 5 d, and tissues were collected at study termination. Daily weights of mice, food, and water were collected from d 14 through d 22. Colon and cecum tissues were analyzed for changes in gene expression, and SCFA concentrations were quantified in cecal contents. Mice provided the PF/DSS treatment exhibited a delayed (P < 0.05) loss in body weight compared with mice provided the CELL/DSS treatment at d 4 and d 5 post‐DSS administration. Furthermore, a diet by water treatment interaction (P < 0.05) was noted for cecal SCFA concentrations, which were higher in the PF/DSS treatment compared with the CELL/DSS treatment. Overall, dietary PF attenuated body weight loss due to experimental colitis in mice, potentially due to the production of SCFA.