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Use of acyclovir to treat chickenpox in pregnancy

Primary non-function of renal allografts, which continues to be a common early problem in transplantation, can be diagnosed when rejection and vascular problems have been excluded and biopsy findings are compatible with acute tubular necrosis. Early studies have defined factors affecting the donor kidney which are associated with primary non-function, and these include prolonged warm and cold ischaemia times. ' We sought to examine whether any non-immunological recipient factors play a part in primary nonfunction. There is substantial evidence that increased influx of calcium into the cell plays a role in cellular toxicity.2 Recent studies have suggested that parathyroid hormone causes increased levels of cytosolic calcium.3 The aim of this study was to review the immunoassayable parathyroid hormone (C terminal) concentrations immediately before transplantation in patients receiving a cadaveric renal transplant and their relation to the incidence of primary non-function.