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Medullated Retinal Nerve Fibers: Speculations on Their Cause and Presentation of Cases

ABSTRACT Twelve patients with medullated retinal nerve fibers are presented. The paper discusses the possible roles played by formation of the (1) ganglion cell axons and (2) lamina cribrosa in the development of medullated retinal nerve fibers. In addition to myopia and amblyopia, patients with medullated retinal nerve fibers may show unusual lens tilts, anterior chamber anomalies, unexpected field losses, and unusual direction of the optic nerve.