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Chronic diazepam treatment in rats causes long‐lasting changes in central [3H]‐5‐hydroxytryptamine and [14C]‐γ‐aminobutyric acid release

The effects of chronic diazepam administration to rats on the central release of [3H]‐5‐hydroxytryptamine ([3H]‐5‐HT) and [14C]‐γ‐aminobutyric acid ([14C]‐GABA, ex vivo) were examined. Chronic (5 and 21 days) administration of diazepam (4 mg kg−1 i.p. daily for 21 days) reduced the K‐evoked (20 mm KCl) release of [3H]‐5‐HT from frontal cortex by approximately 50%. Remarkably, this decrease was still present 1 week after diazepam withdrawal. Chronic diazepam treatment did not significantly affect hippocampal [3H]‐5‐HT release but after 21 days the K‐evoked release of [14C]‐GABA was more than doubled and remained elevated 30 h after withdrawal; it returned to control levels after 1 week, and decreased below control levels after 2 weeks. This study indicates that chronic diazepam treatment produces striking changes in transmitter release in rats that persist long after treatment has ceased.