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Comparison between isolated rat and guinea pig aortae in response to drugs.

Comparison between isolated rat and guinea pig aortae in response to drugs was made. The data indicated that the norepinephrine and KCl concentration effect curves determined in rat aortae were on the left of those determined in guinea pig aortae. When aortae were preconstricted with 60 mM KCl, the relaxation induced by nitroprusside or 3-isobutyl-1-methyl-xanthine was more potent than those in guinea pig aortae. Although bethanechol and isoproterenol were effective to relax rat aortae preconstricted with 1 x 10(-5) M norepinephrine, yet guinea pig aortae preconstricted with norepinephrine were not responsive to bethanechol and isoproterenol in similar concentrations tested. The above results suggested a difference between rat and guinea pig aortae in response to drugs.