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Distribution of glucagonlike peptide I (GLP‐I), glucagon, and glicentin in the rat brain: An immunocytochemical study

Although glucagonlike immunoreactants (GLIs) are present in the central nervous system of several mammalian species, their structural relationship with pancreatic proglucagon is not defined, and their precise anatomical distribution has not been studied extensively. To obtain further information about the structure and biological significance of brain GLIs, the anatomical distribution of three different antigenic determinants of pancreatic proglucagon‐‐glucagonlike peptide I (GLP‐I), glucagon, and glicentin‐‐was mapped in the brain of colchicine‐treated rats by immunocytochemistry using the avidin‐biotin‐peroxidase method.