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Expression and Function of H+/K+‐ATPases in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies and novel treatments are needed. Acid/base homeostasis and transport is altered in cancer cells, and this favors cellular proliferation, invasion, metastasis and resistance to chemotherapy (1). Our studies have shown that pancreatic ducts express gastric and non‐gastric H+/K+‐ATPases, which normally have a physiological role in pancreatic ducts (2).