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Acute effect of prenatal pethidine administration on human fetal brain cyclic AMP levels and ornithine decarboxylase activity.

The acute effect of pethidine administration on cAMP levels and ornithine decarboxylase (ODC) activity of fetal human brain from mid trimester abortion was studied. Both activities remained at the low level up to 9 h after intravenous injection of the drug to the pregnant mother. Our data suggest that pethidine causes at least temporary alterations in the cAMP levels and ODC activity of the fetal developing brain.