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Effect of alprenolol on blood pressure and plasma renin activity in hypertensive patients.

In 17 patients with essential hypertension on chlorthalidone treatment alprenolol was given in double-blind crossover trial. The effect on blood pressure (BP), plasma renin activity (PRA) and blood volume was studied. During chlorthalidone treatment PRA was increased and blood volume decreased. Alprenolol induced a significant decrease in systolic and diastolic BP and PRA. The alprenolol-induced decreases in BP and PRA were significantly correlated. Alprenolol did not influence the decreased blood volume during chlorthalidone treatment. The effect of β-adrenergic blocking agents on the renin release from the kidney and its possible role in the hypotensive effect of these agents are discussed.