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Patterns in Serum Toxicokinetics in Peromyscus Exposed to PFAS.

Per- and polyfluoroalkyl substances (PFAS) are compounds manufactured for use in paints, cleaning agents, fire suppressants, non-stick cookware, food containers, and water-resistant products. Concerns about PFAS stem from their ubiquitous presence in the environment, persistence, and variable/uncertain bioaccumulation and toxicity. In the present study, five perfluoroalkyl acids (PFAAs) and one polyfluoroalkyl substance were administered to white-footed mice (Peromyscus leucopus) to elucidate the kinetics of each chemical over 28 days of exposure. Perfluorooctanoate (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorobutane sulfonate (PFBS) were administered to male and female mice via drinking water. Perfluorooctane sulfonate (PFOS), perfluorononanoate (PFNA), 6:2 fluorotelomer sulfonate (6:2 FTS), and PFHxS were administered to male and female mice via oral gavage. Blood samples collected after 14 or 21 and 28 days of exposure and were analyzed for individual PFAS concentrations via liquid chromatography-tandem mass spectrometry (LC-MS/MS). In general, a plateau in serum concentration in this toxicity test-relevant timeline depended on interactions between (i) the type of PFAS (i.e., perfluoroalkyl sulfonic acids (PFSAs) vs. perfluoroalkyl carboxylic acids (PFCAs) vs. polyfluorinated), (ii) continuous vs. bolus dosing, and (iii) to a lesser extent sex. Specifically, PFCAs were detected at higher concentration in females than males, whereas PFSAs were generally detected at similar levels across sex. An exception occurred when PFHxS yielded higher serum levels in males than females through bolus, but not continuous, dosing. PFAS had the largest impact on serum concentrations while sex had the lowest. As such, future work on the toxicokinetics of PFAS in common ecological receptors would be valuable to further explore these patterns. This article is protected by copyright. All rights reserved.