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EFFECTS OF ELEVATED [K+]0 ON THE RELEASE OF NEUROTRANSMITTERS FROM CORTICAL SYNAPTOSOMES: EFFLUX OR SECRETION?

Abstract— Elevated K+0 elicited a substantial Ca‐independent efflux of accumulated GABA from cortical synaptosomal fractions. Efflux from tissue labelled with either NE or choline was affected considerably less by elevated K+ pulses in the absence of calcium. K‐facilitated Ca‐dependent efflux was large for all three of the accumulated substances. K‐dependent (Ca‐independent) efflux of accumulated GABA was associated with all subcellular fractions exhibiting GABA accumulation whereas K‐facilitated Ca‐dependent efflux was restricted to fractions containing synaptosomes. Eighty per cent of both GABA accumulation and K‐dependent efflux was, however, recovered in a purified synaptosomal fraction. Alanine slightly decreased GABA accumulation, but % K‐dependent efflux was not affected.