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Determination of the Prevalence of Fibrinogen Banks Peninsula Mutation (γ280Tyr→Cys) by PCR

A mutation of Tyr→Cys at position 280 of the γ chain of fibrinogen was recently determined to be the cause for fibrinogen Banks peninsula. A novel polymerase chain reaction/restriction digestion assay for this mutation was developed and used for the screening of 300 apparently healthy European blood donors. None of these subjects carried the mutation.