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Effect of Actinomycin D on Lactic Dehydrogenase Virus Multiplication in Mouse Macrophages

Summary The mouse macrophage tissue culture technique was used to show that LDV multiplication is independent of DNA-dependent RNA synthesis since concentrations of actinomycin D which inhibited host RNA synthesis did not inhibit LDV multiplication. The assistance of Dr. S. Margolis in the determination of RNA synthesis is gratefully acknowledged.