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Obesity Induced Collateral Growth Impairment: Potential Role of Endothelial Activation and Leukocyte Mobilization/Recruitment

To assess potential mechanisms responsible for the impairment of collateral growth observed in obesity, we evaluated endothelial activation and leukocyte mobilization and recruitment in lean and obese mice after focal femoral artery occlusion. Immunoreactivity for ICAM‐1 and F4/80, markers of endothelial activation/inflammation and macrophages respectively, was significantly increased in collateral gracilis arteries at 3 days post‐ ligation (P<0.001) and was greater in obese than lean mice (P<0.01). FACS analysis of circulating cells at baseline (Day 0) and 3 days post‐ligation is presented in the table and indicates major differences between specific cell populations that are mobilized and/or recruited after femoral artery ligation in lean and obese mice. In conclusion, impaired collateral growth in obese mice is associated with enhanced, rather than suppressed endothelial activation and macrophage recruitment, and significant differences exist in the specific bone marrow derived cells that are mobilized and recruited.