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Inhibitory Effect of Sodium Cyclamate and Sodium Saccharin on Tumor Induction by 2-Acetylaminofluorene in Rats

Summary Studies were conducted on the effects of orally administered sodium cyclamate and sodium saccharin on the tumor incidence of female rats fed the carcinogen 2-acetylaminofluorene (AAF). Eleven out of 12 rats (91.7%) fed a natural food stock ration supplemented with 300 mg AAF per kg of diet developed palpable mammary and ear duct tumors during an experimental period of 40 wk in contrast to a tumor incidence of two out of 12 rats (16.7%) in rats fed a similar ration supplemented with 5% sodium cyclamate and six out of 12 rats (50%) fed a diet containing 5% sodium saccharin. Administration of sodium cyclamate and sodium saccharin also resulted in a marked reduction in the size of liver tumors of rats fed AAF as judged by gross and microscopic examination of the livers of surviving rats after 40 wk of feeding.