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HES-1, a novel homeobox gene expressed by murine embryonic stem cells, identifies a new class of homeobox genes.

Homeobox genes encode a conserved 60 amino acid structural motif, termed the homeodomain, which can bind to DNA in a sequence specific manner (1). Comparison of homeodomain sequences from many eukaryotic species has revealed that the structural conservation is also manifest at the primary sequence level with conservation of specific amino acid residues at defined positions within the homeodomain (2, Figure 1). Within the broad sequence consensus, homeodomain sequences can be subdivided into discrete classes on the basis of additional sequence conservation. Individual members of a class are generally > 70 % related at the primary sequence level whereas sequence homology between classes rarely exceeds 50% (2). gene