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Concordance and contradiction concerning cytokines and chemokines in experimental demyelinating disease

Experimental autoimmune encephalomyelitis (EAE) has served as a model for human demyelinating diseases, including multiple sclerosis. EAE is mediated by CD4+ T lymphocytes of the TH1 subset. These T cells produce inflammatory cytokines and chemokines that are associated with pathogenicity. The disease is downregulated by other T cells, presumably of the TH2 subset that secrete a different pattern of cytokines which modulate the activity of the pathogenic TH1 cells. Ongoing studies should provide insight into how the interactions of T‐cell subsets impact on the pathogenesis of autoimmune demyelinating diseases. J. Neurosci. Res. 51:147–153, 1998. © 1998 Wiley‐Liss, Inc.