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Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8‐mediated signalling

Members of the TGF‐β superfamily of ligands bind to and activate surface serine/threonine‐kinase receptors. Transduction of these signals requires the Smad proteins, which transiently interact with the activated receptor complex and are phosphorylated on their C terminus, SSXS site, by the type I receptor. Smad8 is a downstream signalling mediator of ALK2/ActRIA.