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Magnesium contamination from Terumo blood collection tubes.

Components of blood collection tubes have been implicated as interfering substances in various assays, especially immunoassays (1)(2)(3)(4)(5). Possible interfering components for blood collection tubes include the lubricants, clot activators, surfactants, and barrier gels. In 1 study, a surfactant was identified as the interferent (1). To our knowledge, no problems have been reported with general chemistry assays. Here we describe an apparent contamination of Terumo tubes with magnesium.

In an evaluation of collection tubes, we collected samples from volunteers via a Vacutainer system into 3 tubes (Greiner, BD, or Terumo). The samples were obtained with no conscious order of draw, and the 3 types of tubes were treated identically. The fill volume of drawn blood was 5–7 mL for all tubes. The samples were stored at room temperature (∼21 °C) for <45 min before centrifugation. Magnesium …