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The Role of HDLC in the Management of Atherosclerosis Moderated

So let’s first talk briefly about the epidemiology. There is incredibly strong epidemiologic association of low HDLs with coronary disease. That’s why we’re interested. But there have been recent issues that suggest that certain types of genetic causes of low HDL don’t seem to be necessarily associated with increased risk; as well as of course, some well known drug trials that were not all positive. There has been some questioning about HDL and its importance.