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HSPA9 Gene Regulates Erythroid Maturation in Human Hematopoietic Progenitor cells

Myelodysplastic syndromes (MDS) is the most common form of adult myeloid blood cancers within the United States. A high fraction of patients with MDS can further progress to acute myeloid leukemia (AML) without intervention. MDS is a heterogeneous group of blood cancers characterized by abnormal hematopoietic cell maturation, increased apoptosis of bone marrow cells, and peripheral blood cytopenias. Low blood cell counts in MDS patients result in morbidity and mortality due to dysregulation of hemostasis and infection. Up to 25% of MDS patients acquire an interstitial deletion on chromosome 5q, also known as Del(5q). The HSPA9 gene is located in the commonly deleted region and is associated with patients that progress from MDS to AML.