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Prostatic neoplasia in transgenic mice with prostate‐directed overexpression of the c‐myc oncoprotein

Promoter elements within the 5′ DNA region of the rat C(3)1 gene have been shown to direct prostate‐specific expression of gene products when they are fused through recombinant DNA procedures and used to produce transgenic mice. In order to test the in vivo effects of chronic overexpression of the mouse c‐myc protooncogene on the prostate glands of transgenic mice, we created several lines of C(3)1‐c‐myc transgenic mice and then examined the phenotype of males with this genetic alteration.