{'fraction_non_alphanumeric': 0.04231433506044905, 'fraction_numerical': 0.02936096718480138, 'mean_word_length': 4.572115384615385, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Efficacy of Isotonic Seawater Solution on Inflammation of the Ocular Surface in Matrix Metalloproteinase MMP-9-Positive Dry Eye Disease Patients

Purpose: Prospective study to evaluate the anti-inflammatory efficacy of isotonic 
seawater solution on metalloproteinase 9 (MMP-9) levels in the tears of 
patients with dry eye disease (DED). Methods: A total of 50 patients 
were included, with the following dry eye criteria in both eyes: InflammaDry? test initially positive, ocular surface disease 
index (OSDI) score ≥ 12 and Results: The InflammaDry test was 
positive in 100% of the patients (n = 50) and in 100% (n = 100) of the eyes 
before treatment. In 14 (28%) patients the test became negative in both eyes, 
and in 15 (30%) it was negative in one of the eyes. In 43% (n = 43) of the 
positive eyes, MMP-9 became undetectable in the tear fluid following treatment 
with isotonic seawater. This change was statistically significant (p Conclusions: The washes with ophthalmic isotonic seawater 
solution have a significant impact on inflammation of the ocular surface in dry 
eye disease, with an ability to make MMP-9 levels negative in 43% of cases.