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Perioceutics - Where do we stand?

Periodontitis is a multifactorial infectious disease of the supporting structures of the teeth, characterized by destruction of the bone and connective tissue. Specific periodontopathic bacteria and their virulence factors are the primary etiologic agents. However, the interaction of host defense mechanisms and these etiological agents play an important role in the onset and progression of the disease. Research began to focus very closely on bacterial-host interaction, leading to host bacterial interrelationship era. The shift in concentration on host response has led to the development of host modulatory therapies which could improve therapeutic outcomes, slow the progression of disease, allow for more predictable management of patients, and possibly even work as preventive agents against the development of periodontitis. This paper reviews the host modulatory therapy, which is the effective means when used as an adjunct to mechanical periodontal therapy in treating periodontal diseases.