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[Effect of pharmacological stimulation and blockade of alpha-adrenergic receptors on adrenocorticotropic hormone and cortisol in the blood of people of various age].

Age-associated peculiarities of the pituitary-adrenal system reactions to alpha 1-adrenergic preparations were studied in 60 normal adult, elderly and old subjects. Concentrations of ACTH and cortisol in blood were determined by the radioimmune method before and 2 hours after prazosin was given or 20 and 60 min. after intake of phenylephrine hydrochloride. The activation of alpha 1-adrenergic receptors (phenylephrine) caused an increase in the blood concentrations of ACTH and cortisol, whereas the blockade of alpha 1-adrenergic receptors (prazosin) induced an essential decrease in the concentrations of these hormones in blood of the persons investigated at various age. In persons of higher-age groups phenylephrine caused a higher activation of the pituitary-adrenal system.