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Humoral Immune Response to Some Benzylpenicillin Preparations

In this study the humoral immune responses to long‐term administration of benzylpenicillin preparations with and without adjuvants were compared. In 44.4% of the patients on long‐term treatment with a benzylpenicillin preparation containing oil and alum monostearate, an induction of benzylpenicilloyl (BPO)‐specific IgG, IgM and IgE was demonstrated during and after the course. Patients treated with a benzylpenicillin preparation containing no oil and alum monostearate showed only a very weak BPO‐specific IgM and IgG response during the course. In patients in whom long‐term treatment with a benzylpenicillin preparation without adjuvants was initiated by a benzylpenicillin preparation containing oil and alum monostearate, not only BPO‐speific IgM and/or IgG but also IgE were demonstrated in 13.0%. The differences in immunoesponse in the various long‐term courses were significant (P < 0.05). The data suggest that the presence of such adjuvants as oil and alum monostearate has an influence on the synthesis of BPO‐specific antibodies. However, it can not be excluded that the difference in immunogenicity had some unknown connection with the differences in penicillin/blood levels.