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Effects of short‐term treatment with pravastatin on the hepatic synthesis of cholesterol and bile acids in gallstone patients

HMG‐CoA reductase inhibitors are now the therapy of choice in the treatment of hypercholesterolaemia. The effects of long‐term treatment with these substances on plasma lipoproteins, cholesterol metabolism and biliary secretion of lipids have been extensively studied in humans. Much less is known about the effects of short‐term treatment. The aim of this study was to determine the time course of the effects of HMG‐CoA reductase inhibitors on plasma lipoprotein levels as well as cholesterol and bile acid synthesis in gallstone patients.