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Cardiovascular reactivity of genetically hypertensive rats of the Lyon strain.

The cardiovascular sensitivity to noradrenaline (NA), phenylephrine (PE) and angiotensin II (A II) was determined in male rats of the Lyon hypertensive (LH) and normotensive (LN) strains. This study was conducted in young (eight week-old) prehypertensive and in older (21 week-old) LH rats with established hypertension. cardiovascular sensitivity was assessed in the pretreated anesthetized rat by measuring the height (Δ MAP) and the surface of the mean arterial pressure (MAP) peaks evoked by the i.v. injection of different doses of vasoconstrictors. In eight week-old LH rats compared to LN controls the Δ MAP for NA, PE and A II were normal while MAP peak surfaces for NA and A II but not for PE were significantly increased. Twenty-one weekold LH rats exhibited greater Δ MAP and MAP peak surfaces for the three agonists used than did the LH controls. Cocaine injection increased more markedly the responses to NA of 21 week-old LH rats than of LN rats which suggests an enhanced neuronal uptake of NA in adult LH animals.