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Nanotechnology and site-targeted drug delivery

Nanotechnology, building on its ability to control or manipulate structures at the atomic level, promises to develop effective drug-delivery systems. This is to be achieved through creating structures that have novel properties because of their small size. This is not an entirely new concept in site-targeted drug delivery, and this critical review examines recent contributions made by 'nanotechnology' to solve critical issues concerning the development of therapeutically effective and acceptable site-targeted drug delivery systems. It is shown that very little progress has been made. For nanotechnology rationally to generate materials useful in human therapy it will need to progress in full recognition of all the requirements biology places on the acceptability of exogenous materials.