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FAMILY HISTORY OF MELANOMA AND PARKINSON DISEASE RISK

Gao et al.1 found a twofold increase in risk of Parkinson disease (PD)among individuals who reported a family history of melanoma in a first-degree relative compared to those without this family history. We suggest that this association may be partly related to vitamin D deficiency. Furthermore, we suggest that vitamin D receptor (VDR) polymorphisms are a shared common genetic component of both PD and melanoma.

Both VDR and 1-α-hydroxylase—the enzyme responsible for the formation of the active form of the vitamin, 1,25-dihydroxyvitamin D [1,25(OH)2D]—are present in the human brain. The strongest immunohistochemical staining for both the receptor and enzyme …