{'fraction_non_alphanumeric': 0.033936651583710405, 'fraction_numerical': 0.011312217194570135, 'mean_word_length': 5.366906474820144, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
[Recent prognostic factors in vulvar carcinoma: histological, immunohistochemical and flow cytometry studies].

OBJECTIVES
Are newer histologic investigations helpful in the evaluation of the prognosis of vulvar carcinoma?


METHODS
147 primary squamous cell carcinomas of the vulva were examined for overall- and disease-free survival (mean observation 59.6 months).


RESULTS
A significance in prognosis was found for FIGO-stage, a new-created histologic grade, p53- and vimentin-expression and amount of T-lymphocytes in tumoral stroma. Unfavourable prognosis was detected for tumors with elevated growth fraction, high proliferating cell-compartment (S + G2 + M) and increased cytokeratin-8-expression.


CONCLUSIONS
These investigations are able to describe the malignant potential of a vulvar carcinoma and should therefore influence the decision for a modified radical therapy.