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Dietary Advanced Glycation end Products Induced Cognitive Impairment in Aged ICR Mice: Protective Role of Quercetin.

SCOPE
Dietary advanced glycation products (dAGEs) have been reported to induce cognitive impairment while quercetin possesses potential neuro-protective effects. We aimed to explore whether dAGEs would induce similar cognitive impairment from both young and aged ICR mice, and the protective effects of quercetin.


METHODS AND RESULTS
A total of 32 aged ICR mice (15-month-old) and 16 young ICR mice (3-month-old) were randomly assigned into the following 6 groups: Young mice Control group (YC), Young mice fed with AGEs diet group (YA), Old mice Control group (OC), Old mice fed with AGEs diet group (OA), Old mice with quercetin supplemented diet group (OQ), Old mice fed with AGE diet supplemented with quercetin group (OAQ). Dietary AGEs induced cognitive impairment only in aged, but not in young ICR mice, while quercetin intervention is capable of reversing dAGEs induced cognitive dysfunction. This might be due to that quercetin 1) increased miR-219, miR-15a and miR-132 expression, inhibited p-ERK1/2 and tau phosphorylation; and that 2) improved gut microbiota richness and diversity, inhibited phylum Tenericutes and Proteobacteria, as well as elevated butyric acid from cecum.


CONCLUSIONS
Prolonged application of quercetin might be beneficial in the elderly, especially for those with high consumption of dAGEs. This article is protected by copyright. All rights reserved.