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Stress and Atopic Eczema

Most dermatologists acknowledge that stress can have an influence on the progress of atopic eczema (AE). So far we have only very few experimental studies definitely proving this relationship coherence. Psychosocial stress especially is known as a negative influencing factor [1]. Therefore, our study investigates the connection between psychosocial stress and immunological parameters in patients with AE. AE patients as well as healthy controls were asked to participate in a standardized stress experiment and to give samples of blood and saliva during the experiment. Apart from other parameters brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) were measured in the samples, to determine the influence of stress on these parameters. The comparison of NGF values of patients with bronchial asthma and atopy with normal controls shows that 42 of 49 atopic patients displayed elevated NGF values [2]. Besides, NGF and BDNF were elevated after provocation with allergens in bronchial lavage fluid [3]. Aloe et al. [4] studied serum values of NGF in male rats in a stress experiment. As a stressor, fights with other males were used. The higher the stress was (number of fights), the higher the NGF values went up. In studies with humans, parallel findings were determined in soldiers before and after their first parachute jump. NGF values were increased by 84% in the evening before the jump and augmented by 107% after the landing. In soldiers, who did not participate in parachute jumping, the parameters remained constant [5]. Botchkarev et al. [6] showed in an experiment with transgene mice that NGF and BDNF and other neurotrophins have an influence on keratinocytes and the proliferation rate of these cells. He gave them the name ‘epitheliotrophines’ and showed that BDNF is present in nerve fibers in the skin.