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Modeling Of C02-02 Interaction In Respiratory Chemoreflex

A dynamic bilinear model is proposed for the human respiratory chemoreflex, which is composed of three submodels: the CO2 and 02 subsystems which correspond to the individaal effects of CO2 and 02 stimulation, respectively; and the COS-02 subsystem which accounts for the interaction effect of combined CO2 and 02 stimulation. This new model is developed from previous static bilineax models and dynamic models with single-gas stimulation, and contains features that supersede all existing models. In particular, it explicitly includes the CO2-02 subsystem that is functionally independent of the other two subsystems. Our experimental investigations show that with CO2 and 02 input sequences that are mutually unrelated, the C02-02 subsystem can be identified along with the CO2 and 02 subsystems.