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Bonelike®/PLGA Hybrid Materials for Bone Regeneration: In Vivo Evaluation

The biocompatibility and osteoconductive potential of Bonelikeand Bonelike � /PLGA hybrid materials were evaluated through subcutaneous and tibiae implantations for a 4 week period. Qualitative histology was performed to evaluate new bone formation and characterise bone-implant interface and results showed that Bonelike � /PLGA hybrid materials promote extensive bone growth. After the 4 week implantation period, Bonelikeresorption was recognized, which may be due to the presence of resorbableand �-tricalcium phosphate phases.