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Environmental endocrine modulators — where toxicology meets epidemiology

more importantly, strategies to address the open questions. The first steps are to separate fact from hypothesis, and conclusion from speculation. Toxicologists know that there are a multitude of chemicals, synthetic as well as naturally occurring, which can modulate endocrine function. They act by interaction with oestrogen, growth factor or Ah receptors, either directly or indirectly by affecting synthesis and metabolism. They may also directly alter the synthesis and metabolism of oestrogen and other hormones. The end result may be agonistic or antagonistic, often dependent on dose and duration of exposure, and often eliciting different effects in the same organ, or the same effect in different