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[Interaction of digitalis glycoside and catecholamines on the vas deferens of the guinea pig].

The present study was undertaken in order to elucidate the site of drug interaction between digitalis and catecholamines. Experiments were designed to test the effect of digitalis glycoside on catecholamine-induced contraction of vas deferens isolated from guinea pig. Ouabain potentiated the catecholamine-induced contraction of vas deferens. Potentiation by interaction between ouabain and catecholamine was not produced following administration of phenoxybenzamine. In a potassium free medium, ouabain did not produce potentiation of the catecholamine-induced contraction. These results suggest that the interrelated potentiation between catecholamines and ouabain is at the site of the α-adrenergic recepter.