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Production of gelatin microparticles in a flow focusing microfluidic device for biomedical applications

Particles that can mimetize some of the mechanical and geometrical properties of red blood cells and other cellular components of the human body can have important applications in the development of drug delivery carriers and blood substitutes. In this work gelatin microparticles are produced in a droplet microfluidics flow focusing device. Several operating conditions are studied and, for the best conditions, particles of 14-16 m are obtained. Two flow regimes are observed, dripping, when the Capillary number of the dispersed phase is smaller than 0.01, and jetting when the capillary number of the dispersed phase is higher than 0.01.