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EVALUATION OF ANALGESIC EFFECT OF BACLOFEN IN ALBINO RATS IN COMPARISON WITH DICLOFENAC

Aim and objective: To evaluate the analgesic effect of baclofen in albino rats in comparison with diclofenac. Materials and Methods: Eighteen inbred male albino rats weighing about 150-200 gms were selected from central animal house. They were divided into three groups, with six rats in each. Group I served as control received normal feed and water. Group II served as standard received T. Diclofenac – 10 mg/kg (oral). Group III served as test group received T. Baclofen -- 8mg/kg (oral). The analgesic effect of baclofen was evaluated using Eddy’s hot plate method and tail-flick method and compared with diclofenac. The values obtained are expressed as mean ± SEM. Statistical analysis of differences between groups was carried out using one-way analysis of variance (ANOVA). Probability (P) value of <0.05 was taken as the level of statistical significance. Results: Baclofen showed statistically significant analgesic activity in comparison with control group and standard group (P < 0.05). Conclusion: Baclofen a GABA- B agonist has significant analgesic activity comparable to that of diclofenac (P < 0.05)