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A comparative experimental study of quantitative diagnosis of fatty liver by CT and MRI

Objective:To evaluate the correlation and the degree of relationship between hepatic fat content and liver-to-muscle CT value ratio (LMVR)、liver CT value (CTVL) and MR liver signal intensity attenuation ratio (SILAR) before and after fat-suppressed T 1WI respectively.Methods:Non-contrast CT scan,non-fat-suppressed and fat-suppressed spin-echo sequences T 1-weighted MRI were performed in the 5 rabbits of the control group and 23 rabbits randomly chosen from the experimental group.LMVR、CTVL、CTVM and SILAR of each rabbit were measured or calculated. Liver specimens were examined histologically. The ratio of hepatic fat content to liver volume (V v value) was measured by microscopic image pattern analyzer.Results:Significant high degree linear negative correlation (r=-0.896,t=-10.289,P0.001)was found between LMVR and V v value. Significant moderate degree linear negative correlation (r=-0.818,t=-7.249,P0.001)was found between CTVL and V v value. Significant moderate degree linear positive correlation (r=0.556,t=3.407,P=0.002) was found between SILAR and V v value.Conclusion:LMVR has higher degree of relationship than CTVL and SILAR with V v value. This index could be used to assess the degree of fatty infiltration of liver in vivo and noninvasively.