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Bone densitometry by Radiofrequency Echographic Multi-Spectrometry (REMS) in acromegaly patients.

INTRODUCTION
REMS (Radiofrequency Echographic Multi-Spectrometry) is a recently introduced non-ionizing technology employed in evaluation of osteoporosis. The aim of our study was to compare BMD (bone mineral density) in acromegaly patients and healthy controls by performing novel REMS densitometry. Second objective was to analyze the correlation between results of REMS and classical DXA (dual-energy X-ray absorptiometry) in acromegaly patients.


MATERIAL AND METHODS
We enrolled 33 patients with acromegaly (AG) and 24 controls (CG). The acromegaly patients were divided into 2 subgroups: well-controlled acromegaly (WCA) and surgery-cured acromegaly (SCA). REMS was performed in all participants, while DXA only in the acromegaly group. IGF-I and GH levels were measured in acromegaly patients.


RESULTS
BMD of the lumbar spine (LS) and the femoral neck (FN) obtained from REMS did not reveal significant differences between AG, CG, WCA and SCA. Similarly, there were no significant differences in BMD measured by DXA at the LS and at the FN between WCA and SCA. Significant positive correlations between IGF-I concentrations and BMD obtained from both REMS and DXA were detected in the AG and WCA. In the AG and WCA, there were positive correlations between T-scores and LS BMD obtained from both methods.


CONCLUSIONS
REMS could be a potential method in assessment of bone status in acromegaly. Further studies with participation of active disease patients are needed.