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Some phenolic metabolites of 2, 4-diaminotoluene in the rabbit, rat and guinea-pig.

1. After administration of 2,4-diaminotoluene to rabbits, rats and guinea-pigs, phenolic metabolites are excreted, the major component being 5-hydroxy-2,4-diaminotoluene in all species investigated. Acetylated aminophenols and glucuronide conjugates were also found. 2. Rabbits, which produced the largest amounts of free amino-phenols, also had the highest levels of methaemoglobin in vivo.