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Responding to the evidence for improved treatment for cryptococcal meningitis in resource-limited settings.

The World Health Organization (WHO) issued the first evidence-based treatment guidelines for cryptococcal meningitis in December 2011. Although its incidence has decreased with increased access to antiretroviral therapy, cryptococcal meningitis remains a major cause of death in people with HIV/AIDS, with over 500 000 deaths every year in sub-Saharan Africa. It is a leading cause of death in the Medecins sans Frontieres (MSF) HIV/AIDS programmes in Africa.