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Plasma nicotine concentration and the white blood cell count in smokers.

The peripheral blood total white cell count is 20-25% higher in smokers than in non-smokers (for review see ref 1). Smoking probably causes the increase in white cell count. Thus the count is higher in those who smoke and inhale more,2 while a change in cigarette consumption is associated with a corre- sponding change in white cell count, and giving up smoking with a reduction in the count.3 Despite this evidence, the way in which smoking raises the white cell count is unknown. This study was conducted to determine if the white cell count in smokers is related to the concentration of nicotine in plasma or of carbon monoxide in end expired air.