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Cytotoxic Effect of Anti‐H‐2 and Anti‐Ia Antisera on Human B and T Cells

Anti‐H‐2 and anti‐Ia alloimmune mouse antisera were tested by the microcytotoxicity test on human peripheral blood B‐ and T‐cell preparations. Anti‐H‐2 antisera react by a higher titer and/or cytotoxicity scoring grade on B cells than on T cells. Anti‐Ia antisera react practically only with B cells. It was assumed that anti‐H‐2 antisera contain two components. One component reacts specifically with certain HLA‐A‐or ‐B‐locus antigens or other closely linked gene products. The other component reacts predominantly or only with B‐cell determinants; the specificity of the latter component has not yet been studied in sufficient detail.