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A Rapid Method for in Vitro Screening of Immunosuppressants Using Mouse Spleen Cells 1

Summary An in vitro system for quantitatively measuring hemolysin production by mouse spleen cells is described. The synthesis of hemolysin was shown to be de novo and the rate of appearance was linear with respect to culture time. Known immunosuppressive chemicals were tested using this system and were found to be effective at inhibiting antibody production whereas nonimmunosuppressive drugs were noneffective. These findings suggested that this system would be suitable for rapidly screening chemicals for immunosuppressive activity and may be of aid in determining their mode of action at a cellular level.