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Black currant Suppresses Metabolic Syndrome induced by High–Fructose Diet

Metabolic syndrome is a medical disorder characterized by obesity, hyperglycemia, dyslipidemia, and hypertension. Black currant (Ribes nigrum L, BC) has been used for horticultural crop in europe nations. The present study was designed to investigate the beneficial effect of BC on metabolic syndrome. To induce metabolic syndrome, rats were fed the 65% high fructose diet. Treatment with BC (100 or 300 mg/kg/day BC for 8 weeks) significantly suppressed the increments of epididymal fat weight, blood pressure, plasma total cholesterol (T‐cho), triacylglycerol (TG), LDL‐cholesterol, and insulin levels and ameliorated oral glucose tolerance, respectively, in the metabolic syndrome rat. In addition, BC markedly prevented increases of adipocyte size and hepatic accumulation of TG. BC ameliorated endothelial dysfunction by down regulation of endothelin‐1 (ET‐1) and adhesion molecules in the aorta. Moreover, vascular relaxation of thoracic aortic ring by acetylcholine was improvement by BC. These findings suggest that BC ameliorates dyslipidemia, hypertension, insulin resistance in rats with Metabolic syndrome. Taken together, BC may be used for therapeutic approach for metabolic syndrome.