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Insulin Requirement in Non‐insulin‐dependent Diabetes Mellitus: Relation to Simple Tests of Islet B‐cell Function and Insulin Sensitivity

Evaluation of simple tests of islet B‐cell function and insulin sensitivity as predictors of metabolic control was performed during 3 months of insulin withdrawal in 25 insulin‐treated diabetic subjects. All patients had a glucagon stimulated plasma C‐peptide concentration above 0.33 nmol/l and a fasting plasma C‐peptide concentration above 0.20 nmol/l a few days before insulin withdrawal. Insulin sensitivity was measured as the glucose disappearance rate (k) during an intravenous insulin tolerance test. Two patients were considered insulin‐requiring due to high fasting blood glucose levels (>20 mmol/l) and two patients due to an increase in glycosylated haemoglobin of more than 1.1% (>∼3SD) in combination with weight loss. None of the remaining patients had a significant increase in glycosylated haemoglobin.