{'fraction_non_alphanumeric': 0.04221453287197232, 'fraction_numerical': 0.04083044982698962, 'mean_word_length': 4.784, 'pattern_counts': {'":': 0, '<': 2, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Studies on the pattern of circulating steroids in the normal menstrual cycle. 5. Changes around the onset of menstruation.

Changes in the pattern of circulating steroids in the normal menstrual cycle around the onset of menstruation were studied in 6 women. Blood was drawn continuously at a rate of 4 ml/hour and plasma levels of pregnenolone (Preg) progesterone (P) 17-hydroxypregnenolone (17-OHPreg) 17-hydroxyprogesterone (17-OHP) 20 alpha-dehydroprogesterone (20-DHP) cortisol (C) dehydroepiandrosterone (DHE) androstenedione (AND) testosterone (T) dihydrotestosterone (DHT) estradiol-beta (E2) and luteinizing hormone (LH) were determined during 14 3-hour sampling periods. C 17-OHPreg and DHE showed marked circadian rhythm with highest means in the morning between 0600-0900 hours and lowest between 2100-0300 hours. The correlation of these 3 steroids was significant (p < .001). There was also circadian variation in 17-OHP AND and Preg but it was less pronounced with lower amplitudes and a larger spread of individual peaks. The correlation of these 3 steroids with cortisol was significant (ps < .001 .001 and .01 respectively). A steady decrease in the values of P 20-DHP T and E2 was seen without any circadian variation. When plasma LH values were analyzed for the 1st and 2nd halves of the sampling time a signifcant increase was seen negatively correlating with P and 20-DHP. Total LH and DHT however had no signifcant change.