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Brain age estimation from T1-weighted images using effective local features

Statistical analysis using large-scale brain magnetic resonance (MR) image databases has examined that brain tissues have age-related morphological changes. The age of a subject can be estimated from the brain MR image by evaluating morphological changes with healthy aging. This paper proposes an age estimation method using local features of T1-weighted MR images. The brain local features are defined by volumes of brain tissues parcellated into 1,024 local regions defined by the automated anatomical labeling atlas. This paper also proposes the effective local feature selection method to improve the accuracy of age estimation. We evaluate the accuracy of the proposed method using 1,099 T1-weighted images from a Japanese MR image database. We also analyze effectiveness of each local region for age estimation and discuss its medical implication.