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Homozygous HbE and HbSE disease in a Saudi family.

The unusual combination of haemoglobins S and E was found in two Saudi Arab siblings. The father was homozygous for HbE and the mother was heterozygous for HbA and HbS. Clinical and laboratory findings are presented and compared with those of the six cases of HbSE heterozygosity previously reported. The significance of the HbE gene as a demographic marker in the Middle East is discussed.