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Nucleotide sequence upstream of a glucose-repressible Drosophila gene.

Negative regulation of gene expression is very rare among higher eukaryotes (1). Recently, we have shown that Drosophila alphaamylase genes are glucose-repressible (2) and we have determined their nucleotide sequences (3). Here, we extend the sequence of the proximal amylase locus by 1.2kb to a point 1.6kb upstream of the initiation codon, ATG. There is a repeated sequence motif, ACCCCACTGC, (indicated by arrows) which has significant sequence homology to a repeated regulatory element upstream of a negatively regulated mammalian gene (1). We found that this sequence element is also present upstream of the murine amylase gene (4). In addition, there is.a poly(dA-dT) tract (underlined) which is a characteristic upstream sequence in many lower eukaryote genes (5). Other eukaryotic regulatory motifs (e.g. TATA) are boxed. It will be of interest to compare this sequence to the upstream regions of other negatively regulated eukaryotic genes, as such sequences become available.