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NICBPM: Non-invasive cuff-less blood pressure monitor

An ultra-low power, ultra portable, wearable integrated bio-medical device, the Non-Invasive Cuff-less Blood Pressure Monitor (NICBPM) is proposed to measure the Pulse Transit Time (PTT). The relationship between PTT and Blood Pressure (BP) is investigated using linear and non linear regression models. Simultaneous reading obtained from an FDA approved, commercially available Blood Pressure monitor and the (Electrocardiogram) ECG and (photoplethsymogram) PPG signal from the NICBPM are used to calibrate the device for 30 subjects during cardiopulmonary exercise test. Bland-Altman plots for the linear regression model revealed limits of agreement of −10.6 to 10.6 mmHg for systolic BP (sBP) and −10.5 to 10.5 mmHg for distolic BP (dBP). Bland-Altman plots for the non linear regression model revealed marginally better limits of agreement between −8.5 to 8.5 mmHg for sBP and −6.6 to 6.6 mmHg for dBP. sBP can be estimated from the NICBPM with 99% accuracy and 99% sensitivity.