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Disposition of fusidic acid during peritoneal dialysis

Summary: Fusidic acid has characteristics that suggest it might be a useful agent in the management of staphylococcal peritonitis in patients undergoing peritoneal dialysis. the present investigation was undertaken to establish the relationship between serum and peritoneal dialysis effluent concentrations of fusidic acid and to determine whether therapeutic levels of fusidic acid could be achieved in the dialysate following oral administration of the agent. Concentrations of fusidic acid up to 80 times the MIC for staphylococci were found after repeated oral doses. the results have provided basic data needed to initiate clinical studies of the role of fusidic acid as an adjunctive agent in the management of staphylococcal peritonitis.