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Clinical , Biochemical and Ultrasonographic Evaluation in Early Diagnosis of Dengue Haemorrhagic Fever

Objectives: The object of this study is to evaluate clinical, biochemical and ultrasonographyic findings in early diagnosis of Dengue Hemorrhagic Fever (DHF). Design: A case series. Place study: The study was carried out in Medical Department of CMH and Mayo Hospital, Lahore. Methodology: 351 patients suspected of DHF were enrolled in two different hospitals of Lahore during outbreak of the disease. The diagnosis was confirmed by serology. Results: The most common symptom in 100% patients was fever followed by musculoskeletal pain. Liver biomarkers were elevated in 237 (77.9%) patients throughout the coarse of illness, reaching peak on 3rd day and declining after 7th day of illness. The sonographic features included hepatomegaly in 234 (77.2%) patients, pleural effusion in 226 (74.6%), thickening of gallbladder wall in 221 (72.9%) and ascites in 209 (69%). Conclusion: Liver biomarkers and abdominal ultrasonography can be used as first line of imaging modality in patients, suspected of DHF prior to serological confirmation in dengue epidemic area.