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Deep tissue light sheet imaging with structured illumination

Traditional optical imaging systems are designed with the assumption that light travels along straight paths inside the sample. Light scattering in biological tissue leads to high background and blurry images in traditional imaging methods. We report technique advancements in structured illumination with light sheet imaging (SIM-LS) in deep tissue. SIM-LS is capable of removing image background generated by scattering and restoring optical resolution in deep tissue imaging. With two-photon Bessel beam excitation, SIM-LS supports up to 500 micron wide field of view 3D imaging in embryos and brain tissue at subcellular resolution.