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Application of HIF‐1α by gene therapy enhances angiogenesis and osteogenesis in alveolar bone defect regeneration

A successful clinical outcome for implanted tissue‐engineered bone is dependent on the establishment of a functional vascular network. Gene‐enhanced tissue engineering represents a promising approach for vascularization and osteogenesis. In the present study, we tested the angiogenesis and osteogenesis efficacy of gelatin as the scaffold carrier in combination with a virus encoding the HIF‐1α gene in a rat alveolar bone defect model.