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Filaggrin expression via immunohistochemistry in basal cell carcinoma and squamous cell carcinoma

Filaggrin is a protein integral to the structure and function of the epidermis. Filaggrin (FLG) loss‐of‐function (LOF) mutations are common and increase the risk of developing atopic dermatitis (AD) and ichthyosis vulgaris (IV). Epidemiologic data suggest a link between skin cancer and AD. We examined if FLG staining pattern can be used to characterize cutaneous squamous cell carcinomas (SCC), basal cell carcinomas (BCC), and reactive squamous epithelium.