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171A: THREE DIMENSIONAL POLY-LACTIDE-GLYCOLIC ACID (PLGA) AND TYPE I COLLAGEN SCAFFOLDS EXERT AN OPPOSITE EFFECT ON OSTEOGENISIS IN HUMAN AND MOUSE OSTEOBLASTS

Introduction: Joint surfaces injuries arise from repetitive or traumatic high impact loading and are a common and potentially debilitating problem. Repair strategies focus on the creation of scar tissue, which is biomechanically inferior to articular cartilage. Previous studies have demonstrated the ability of tissue-engineered cartilage to bond to articular cartilage; however the ability to bond to subchondral bone is uncharacterized. The goal of this study is to characterize the bond formed between native cartilage, engineered cartilage and subchondral bone using histology and biomechanical testing.