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Effectiveness of Cellular Phone-Based Interventions for Weight Loss in Overweight and Obese Adults: A Systematic Review

Background: In response to the rapid increase in obesity and its association with chronic diseases, World Health Organization has declared an immediate need for effective and widely-accessible interventions for weight management. Cellular phones are portable, convenient, and popular among people of varying economic status and geographic regions; hence, they offer a viable medium for delivering weight loss interventions. Objective: To determine whether cellular phones are an effective medium for delivering weight loss interventions in adults who are overweight or obese. Methods: A literature search was conducted to retrieve articles published prior to February 2012. Studies were included if they: 1) included adults with a body mass index (BMI) of 25 or higher and with no known chronic condition, 2) delivered a weight loss intervention using a cellular phone, 3) measured weight, BMI, waist circumference, body fat or any other proxy for weight loss, 4) had a comparison group, and 5) were published in English. At least two reviewers independently screened all titles and abstracts and reviewed the included articles. Results: 193 unique citations were screened; of those, six studies met inclusion criteria. Mobile interventions varied from phone calls and short message service (SMS) messaging to emails, websites and podcasts. Among studies of one-way interactive interventions (i.e., the researcher could contact the participants, but the participants could not respond), one high quality randomized controlled trial (RCT) showed a small but statistically significant effect in weight reduction, favoring the intervention, and one low quality study reported no significant difference compared to printed material. Of the four studies on two-way interactive interventions (i.e., there was open communication between researchers and participants), two RCTs demonstrated statistically significant difference for weight and waist circumference, while one showed no significant difference. When compared to a clinic-based intervention, one low quality study showed that an internet/SMS weight loss intervention was inferior to regular clinic visits. Conclusion: Due to the small number of high quality studies, modest evidence was found for the effectiveness of cellular phones in the delivery of weight loss interventions for people who were overweight or obese.


Introduction
Since 1980, the prevalence of obesity has more than doubled worldwide and according to Statistics Canada, roughly 4.6 million Canadian adults were classified as overweight or obese [1,2]. Chronic diseases such as hypertension, type 2 diabetes, cardiovascular disease and stroke are often a result of carrying this excessive weight [3][4][5][6]. The ramifications of being overweight and obesity extend beyond the aforementioned health consequences. In 2008, obesity accounted for $4.6 billion of the Canada economy [7] and the costs reached as high as $147 billion in the United States of America [8,9]. It has been shown that as little as a 5-10% reduction in weight decreases the risk for hypertension [10], coronary artery disease [11], and diabetes mellitus [12] by up to 20%.
Body mass index (BMI) is commonly used as a measure of this health risk and is defined as a person's body mass in kilograms divided by height in meters squared. The World Health Organization (WHO) has defined overweight as anyone with a BMI of 25.0 to 29.9 kg/m 2 and obese as anyone with a BMI greater than or equal to 30 kg/m 2 [2]. The rapid increase in obesity, its correlation with other serious diseases and its significant economic impact have led WHO to declare an immediate need for effective and widely-accessible weight loss interventions for process and attrition rate, quality appraisal, participant characteristics, intervention characteristics (i.e., interactivity and duration), outcomes measures and results. Any disagreement between the reviewers was resolved by a third independent reviewer.

Data analysis
The study designs and types of interventions were initially assessed for methodological and conceptual similarities. Since the application of cellular phone-based intervention varied widely in the included studies, a meta-analysis would be inappropriate. Hence, we summarized the results narrative. Our preliminary review indicated that the frequency of interactions between researchers and participants via cellular phone varied between studies; hence, we categorized the interventions into two groups: 1) one-way interaction, in which the researcher could contact the participants, but the participants could not respond; 2) two-way interaction, in which there was open communication between researchers and participants.
For each study, we reported results of the outcome measures separately and in their natural units. For continuous variables, effect size, such as standardized mean difference (Cohen's ɗ ), was calculated between the experimental group (EG) and the comparison group (CG), if possible. According to Cohen, an effect size of 0.2 is considered a small effect, 0.5 a medium effect, and 0.8 a large effect [24].

Results
A total of 298 articles were retrieved, and 193 remained after duplications were removed ( Figure 1). Of those remaining, 154 articles were excluded after the title and abstract screening. Of the 39 studies that advanced to the full article review; 33 did not meet the inclusion criteria (Table 1) [5,18,20,21,[25][26][27][28][29], leaving six studies included in this review (Table 2) [6,19,35,48,52,53]. Most included studies incorporated the use of cellular phone as a part of a multifaceted weight loss program, rather than a standalone intervention.

Interventions involving one-way interaction
Two studies examined weight loss interventions involving oneway interaction via cellular phone. One study was a cluster RCT [53] and the second was a CCT [35]. Lombard et al. [53] investigated 250 interventions. Current evidence suggests that text messaging may improve compliance with medication and medical appointments and supports a healthy life style [14][15][16][17]; hence the use of cellular phones has potential for facilitating healthy behaviors and improving health outcomes.
The increasing use of cellular phones among varying age groups, socio-economic backgrounds and ethnic groups make it a feasible medium for delivery of weight loss interventions [18,19]. Possible additional benefits to using cellular phones as a medium for weight loss interventions include cost-effectiveness, large scale delivery, portability, and the ability to deliver individualized information rapidly and in a variety of locations [5,6,20]. Moreover, information can be transmitted to a cellular phone without the user having to initiate a request, which is usually required to access a computerized program [5,6,20].
Mobile technology is rapidly advancing, which is reflected by new research including interventions delivered using smart phone applications and games [21]. It is likely that as cellular phones become more ubiquitous and technologically advanced, they will become a popular method of weight loss intervention delivery. Therefore, the purpose of this review is to determine if cellular phone is an effective medium for delivering weight loss interventions in adults who are overweight or obese.

Criteria for study inclusion
Studies were included in the review if they: 1) included participants aged 18 years or older, with a BMI of 25 or higher, and with no known chronic condition at the time of enrolment; 2) included weight loss interventions delivered by a cellular phone; 3) reported outcome measures including weight, BMI, waist circumference, body fat or any other proxy for weight loss; 4) were randomized controlled trials (RCTs), controlled clinical trials (CCTs), or controlled beforeand-after studies; and 5) were published in English. Devices were considered cellular phones if they had the capacity to make and receive telephone calls and SMS texts over a radio link protocol covering a wide geographical area. Smartphone capabilities, such as data access to the internet and ability to support applications, were not eligibility requirements in this review.

Literature search, quality asssessment and data extraction
An electronic database search using MEDLINE, EMBASE, CINAHL, the Cochrane Library and PsycINFO was conducted in February 2012. Appendix 1 presents the search strategy developed for MEDLINE. At least two reviewers (JC, VG, RL, NM, JW) screened each title and abstract for relevance based on the study inclusion criteria. Any discrepancies were discussed among the reviewers and disagreement was resolved by a third independent reviewer on the team. Abstracts with missing information were included in the full paper review.
All included studies were assessed by two independent reviewers for methodological quality using the 11-item PEDro Scale [22], which was designed for rating methodological quality of RCTs (Appendix 2) [23] (Table 3).Ten of the items pertain to internal validity of a trial. The remaining item pertains to external validity and is, therefore, not included in the calculation of the total PEDro score (range=0-10). A score of six or higher indicates high methodological quality [22]. Data extraction was performed using a standardized data extraction form developed by the researchers. It recorded information including study design, research setting, sample size, participant recruitment  The EG attended four interactive group meetings facilitated by a dietitian to discuss goal-setting and steps to achieving healthy-eating behavior. From weeks 4 to 52, they received weekly personalized text messages, this contained information on nutrition, behavioral change and physical activity. The CG received usual care consisting of a single, non-interactive 30-minute lecture on general physical activity and diet recommendations, and a pedometer for self-monitoring. After one year, the EG had lost weight while the CG showed an increase in weight and waist circumference (EG: weight=-0.2kg, [95% confidence interval -CI: -0.9,-0.5], waist circumference=-1.3 cm [95% CI: -2.4,-0.2]; CG: weight=0.8 kg [95% CI: 0.1, 1.5], waist circumference=0.1 cm [95% CI: -1.0, 1.2]). Effect size for body weight change, adjusted for baseline, weight, age, income, education and clustering in the multivariable analysis, was -0.99 (95% CI: -1.90, -0.08). We were unable to estimate the effect size for waist circumference due to insufficient data. This study received a PEDro score of 9 out of 10.
In a CCT, Lee et al. [35] compared a 12-week self-management program plus bi-weekly text messaging to encourage weight management behaviors (i.e., EG) to a one-hour walking program held three times per week (i.e., CG). Both groups (n=108 women) received brief instructions on how to exercise and brochures on healthy diets. The study reported a decrease in body weight, BMI and percentage of body fat in both groups, although none achieved statistical significance. We were unable to calculate the effect size since no measure of variability was reported. The dropout rate in this study was high, with 55.0% in the EG and 54.2% in the CG. Given the methodological issues, this study received a PEDro score of 2.

Interventions involving two-way interaction
Four studies investigated the effect of two-way interactive weight loss interventions delivered by cellular phones. These included three RCTs [6,19,54] and one CCT [52]. In the first RCT (PEDro score=7), Haapala et al. [19] investigated the effectiveness of a 12-month intervention that used a cellular phone-operated weight loss application (app), Weight Balance. A total of 125 participants were randomized into the cellular phone app group (i.e., EG) or the control group (i.e., CG). This app allowed participants to report their current weight and receive SMS messages with feedback regarding their weight. It also calculated the amount of food that individuals should be eating, and the number of days until they reached their goal. These messages also encouraged participants to increase their daily physical activity and reminded them to report their weight. At 12 months, all anthropometric measures were found to have decreased significantly for participants with access to the application compared to the group with no intervention. The standardized mean difference was -0.50 (95% CI = -0.94, -0.23) for body weight and-0.59 (95% CI = -0.94, -0.23) for waist circumference.
The second RCT (PEDro score=5), by Patrick et al. [6], randomized 78 participants to receive monthly printed material on weight control (i.e., CG) or a personalized weight loss program involving cellular phone use (i.e., EG). The latter received personalized SMS and multimedia message service (MMS) messages two to five times a day, printed material, and a brief monthly call by a health counselor. This16-week study measured body weight as the primary outcome. The results indicated a statistically significant effect (standardized mean difference=-3.06; 95% CI=-3.88, -2.24), favoring the EG.
In the third RCT (PEDro score=6), Turner-McGreevy and Tate [54] examined whether a combination of podcasts, Twitter and a diet and physical activity monitoring app, all delivered via cellular phone, could assist people in weight loss. The comparison group was granted access to the same podcasts, plus printed material. After the 6-month intervention period, there was no significant difference in changes in body weight between groups. The standardized mean difference was 0 (95% CI=-0.40, 0.40).
Finally, Joo et al. [52] conducted a CCT to compare a 12-week internet/cell phone-based intervention (i.e., EG) with an intensive clinic-based weight loss program, involving weekly/bi-weekly visits with registered nurses, nutritionists and exercise trainers (i.e., CG). The EG received educational information, weekly SMS prompts for

Study Reasons for exclusion
Ferrer-Roca 2004 [55] The cellular phone intervention was used for blood glucose monitoring rather than weight loss   behavior modification, and online resources on healthy eating and exercise [52]. Compared to the EG, participants in the CG showed greater reductions in body weight (SMD=0.59; 95% CI=0.36, 0.83), BMI (SMD=0.21; 95% CI=-0.02, 0.44) and waist circumference (SMD=0.23; 95% CI=0.00, 0.46). This was the only included study that conducted an economic evaluation. The authors reported that, among the protocol completers, the cost per person achieving the target weight reduction was $975 in the CG, compared to $1,637 per person in the EG. The latter was more expensive because they included the costs for website development and upgrade, as well as information technology personnel. These results, however, should be interpreted with caution due to methodological issues, such as a high dropout rate (67.8%; 628 of 925 enrolled participants).

Discussion
Based on the six studies reviewed, we found evidence supporting cellular phone-based weight loss interventions in overweight and obese adults; however, the results should be interpreted with caution due to the small number of high quality papers. Interventions delivered by cellular phones varied from text messaging and websites to mobile apps that monitor diet and physical activity. Two studies used cellular phone as a single weight loss intervention, while four used it as a part of a multifaceted intervention. The heterogeneity of the interventions has rendered a meta-analysis inappropriate. The level of interactivity of the interventions did not seem to affect the findings. Among studies of oneway interactive interventions, one high quality RCT showed a small but statistically significant effect in weight [53], favoring the intervention; and one low quality study reported no significant difference compared to printed material. Of the four studies on two-way interactive interventions, two RCTs (one high quality [19] and one low quality [6]) demonstrated moderate effects for weight and waist circumference, supporting the intervention; while one high quality RCT showed no significant difference [54,55]. However, when compared to a clinicbased intervention, one low quality study showed that an internet/SMS weight loss intervention was inferior to regular clinic visits. Based on the PEDro scores, three of the six studies were deemed as high quality; however, it should be noted that one of these studies [54] did not apply proper blinding even it has a score of 6.
Several limitations in the review process should be taken into consideration while interpreting our findings. First, while we conducted a comprehensive literature search, this review only included studies published up to February 2012. Second, by limiting studies to the ones that included participants with no known chronic conditions, the generalizability of results is limited as most people who are obese have a number of co-morbid conditions, such as hypertension and cardiovascular disease. Third, only English articles were included due to the cost for translation. The exclusion of foreign articles might result in selection bias. Fourth, we did not contact study authors to obtain additional information for studies with insufficient data for an effect size calculation or search the reference lists of included articles. Finally, we did not limit the type of cellular phones applications in the current review. The heterogeneity in the types of interventions has limited our ability to derive a robust conclusion.
Although our literature search was not limited to any particular year, all eligible studies were published in or after 2009; hence, this is a relatively new field. The versatility of using cellular phone to deliver lifestyle interventions is particularly attractive to people living in areas where local access to weight management program is limited. However, we found none of the included studies explored the use of cellular phone-based interventions in rural and remote regions or for underserviced populations. This knowledge gap should be a focus of future studies. Also, participants in these studies were at their middle age (mean age ranged from 37 to 47 years). Since cellular phone ownership is ubiquitous among young people, the effects of cellular phone-based intervention may be different for the younger age group.
Findings from this review are comparable with the current evidence on the use of cellular phone-based interventions for supporting healthy behaviors. Fjeldsoe et al. [15] examined the use of SMS for supporting healthy behaviors, including smoking cessation, increased physical activity and participation in chronic disease self-management. Their review, which included a variety of study designs, found 13 out of 14 studies demonstrated an improvement in healthy behaviors. The authors also concluded that tailored content and interactivity were important features of successful SMS interventions. A second narrative review by Wei et al. [17] concurred that the use of SMS could improve individual's self-management behaviors, including adherence to medication and medical monitoring.
Findings from the recent Cochrane reviews, however, were less enthusiastic. De Jongh et al. [14] identified four RCTs that assessed the effects of cellular phone messaging to facilitate self-management. They found moderate quality evidence in improving self-efficacy in patients with diabetes and medication adherence in those with hypertension, but no statistically significant effect on the compliance with peak expiratory flow measurement in patients with asthma. In the second review, Vodopivec et al. [16] found limited evidence supporting the use of SMS to deliver preventive health care, including prenatal support, use of vitamin C, smoking cessation and childhood weight control. All included studies had a follow up period of 12 months or less. Similar  1 This item influences external validity of a study. It is different from the remaining PEDro items, which pertains to internal validity. Therefore, it is not included in the calculation of the final PEDro score (http://www.pedro.org.au/english/downloads/pedro-scale/).
2ITT indicates the statistical analysis involved an intention-to-treat analysis.
3 The total score is the sum of Items 2-11 (higher score=higher quality). A score of ≥ 6 indicates a study of high methodological quality. to the previous reviews, our review also highlights two major issues in research on cellular phone-based interventions: 1) limited number of high quality studies; 2) lack of long term follow-up.

4P:Present
Findings from our systematic review suggest that of weight loss interventions delivered by cellular phones may be effective for overweight adults. Continued research in this area will help to inform community-based interventions and clinical practice. The versatility of mobile technologies provides tremendous opportunities for delivering health-related interventions across geographic locations; hence, there is an opportunity to evaluate interventions that are tailored for people living in rural and remote communities. Lastly, studies with a longer follow-up period will be needed. This type of information, along with rigorous cost-effectiveness analyses, can illustrate the sustainability of weight loss interventions delivered by cellular phones.