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Heparin‐binding growth factor(s) derived from head and neck squamous cell carcinomas induce endothelial cell proliferation

Tumor growth is dependent on the expansion and proliferation of the host vascular system into the primary neoplasm (angiogenesis). The development of an intact vascular system requires migration and proliferation of endothelial cells and assembly into microvessels. Previous studies in our laboratory demonstrated that head and neck squamous cell carcinomas (HNSCC) are angiogenic in vivo. To clarify the mechanism of HNSCC‐induced angiogenesis, the present study sought to determine if HNSCCs produced endothelial cell mitogens in vitro.