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Serum Enzymes Following Repetitive Hyperthermia 1 2

Summary The artificial heating of dogs to rectal temperatures of 41.5° on 4 consecutive days resulted in an increase in the serum enzymes SGOT and SGPT and in isocitric dehydrogenase. Blood samples were taken prior to the first heating and prior to the fifth heating so that body temperatures and plasma hemoglobin values were at normal levels. No significant enzyme changes were noted in a group of control dogs subjected to the same procedures as the hyperthermic group except the repeated heating. The results indicate acute hepatic injury.