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Herpes Simplex Virus-induced Enhancement of Mitochondrial

Infection of thymidine kinaseless mouse cells (CI-ID) by herpes simplex virus (type I) was found to result in a stimulation of thymidine uptake into mitochondrial DNA (mtDNA) during a pulse interval from I to 6 h post-infection (p.i.). Thymidine incorporation into mtDNA by organelles isolated at 6 h p.i. from infected cells exceeded that of mock-infected controls significantly. An identical mitochondrial reaction was observed when infected cell cultures were pretreated with 2/zg cytosine arabinoside (ara C)/ml culture medium from I to 6 h p.i. Administration of 2 5 #g cycloheximide/ml instead of ara C abolished the effect of virus infection on mtDNA synthesis. The implications of these observations are discussed with respect to regulation of mtDNA synthesis in eukaryotic cells.