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Desensitization. IV: Permeability changes during active and passive desensitization.

The systemic injection of large amounts of specific antigen (active desensitization) or exogenous lymphokine-containing preparations (passive desensitization) leads to a state of anergy or hyporesponsiveness with respect to cellular immunity without effect on antibody production. In the present study, we show that desensitization is associated with the suppression of permeability alterations at the skin reaction site. This effect is not confined to delayed hypersensitivity responses; it is observed in antibody-mediated and nonimmunologically induced reactions as well. Thus, although the mechanism of desensitization involves the cellular rather than the humoral limb of the immune response, it is possible for the expression of a variety of inflammatory responses to be modified during this state.