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Drug–drug interactions in the medical intensive care unit: an assessment of frequency, severity and the medications involved

Mortality and morbidity are increased in patients experiencing drug–drug interactions (DDIs). Critically ill patients are at an increased risk of adverse events from DDIs due to the large number of medications that they take and their changes in organ function. Currently, there is a lack of literature describing DDIs in the intensive care unit (ICU). The purpose of this study is to evaluate frequency, severity and drug combinations involved in DDIs occurring in a medical ICU (MICU).