{'fraction_non_alphanumeric': 0.03678678678678678, 'fraction_numerical': 0.006756756756756757, 'mean_word_length': 4.8464912280701755, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Inhibitory effect of MAX-PROBIO against Helicobacter pylori in in vitro and in vivo experiments

Purpose: H.pyloriis a major cause of gastritis and gastric ulcer. In recent years, it has been reported that probiotic has an inhibitory effect on H.pyloricolonization. MAX-PROBIO, a probiotic product, contains 44 strains such as lactic acid bacteria and bifidobacteria. In this study, in vitro and in vivo experiments were performed to assess the inhibitory effect of MAX-PROBIO on H. pylori. Methods: In the in vitro experiment, MAX-PROBIO was added to Brucella broth adjusted to pH 3, and the mixture was incubated. H.pyloricultures were incubated under microaerophilic conditions at 37°C with the broth culture supernatant. The viability of H.pyloriafter incubation was assessed by counting the number of viable colonies. In the in vivo experiment, H.pyloriwas inoculated orally to mice (C57BL/6JJms Slc). MAX-PROBIO was then orally administered to the H.pylori-infected mice for 4 weeks, and the number of viable H.pyloriin the stomach was counted. Results and Conclusion: The number of viable H.pylori was significantly decreased in the culture supernatant cultured (in vitro) and in the stomach of MAX-PROBIO-administered mice (in vivo). These findings revealed that MAX-PROBIO contributes to suppression of growth of H. pylori.