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Reciprocal altered expression of T‐cadherin and P‐cadherin in psoriasis vulgaris

Summary  Background The most characteristic change in psoriasis vulgaris is markedly increased, persistent keratinocyte proliferation. The underlying mechanism of excessive epidermal growth is controversial. We previously found and reported that T‐cadherin was expressed in keratinocytes and confined to the basal layer of mouse and human skin. Invasive cutaneous squamous cell carcinoma showed a loss of T‐cadherin expression. Another study showed that T‐cadherin was a negative growth regulator of epidermal growth factor in T‐cadherin transfectant neuroblastoma cells.