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Latex agglutination test in the diagnosis of group B streptococcus and of haemophilus influenzae type B infections.

The effectiveness of a commercially available latex agglutination test (Wellcogen* Strep B and H. influenzae b, Wellcome Diagnostics) in the diagnosis of invasive group B streptococcus (GBS) and Haemophilus influenzae type b (H. influenzae type b) infections was evaluated. All 16 patients with bacteriologically-proven GBS infection and all 9 patients with H. inffuenzae type b infection (sensitivity 100%) were correctly diagnosed. One of the 35 patients with proven non-GBS infection had positive urine latex agglutination test (specificity 97%); 2 of 25 Patients with proven non-H. influenzae type b infection had positive urine latex agglution test (specificity 92%). Wellcogen* is a sensitive, specific and commercially availoble test for rapid diagnosis of GBS and H. influenzae type b infections. Also, it appears to be a particularly useful test for evaluating patients previously treated with antimicrobial therapy, in whom cultures may be negative.