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Hypertrophic cardiomyopathy and left ventricular hypertrabeculation: evidence for an overlapping phenotype

Two female siblings (A and B) were referred for clinical screening following the sudden death of their mother aged 45 years from hypertrophic cardiomyopathy (diagnosed post-mortem). The sisters complained of fatigue, exertional dyspnoea (New York Heart Association functional class II), and infrequent palpitations. Their 12 lead ECGs are shown in panels A and B.

In patient A, the echocardiogram demonstrated asymmetric hypertrophy of the interventricular septum …