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Comparative clinical trials with diclofenac sodium (Voltarol) and naproxen in rheumatic conditions: investigation of possible changes in diclofenac dose and dose interval.

In an open, comparative multicentre trial, 96 patients with arthritis of the large joints were treated with 75 mg diclofenac in one single dose in the morning, 50 mg diclofenac given twice daily, or 250 mg naproxen administered twice a day. It was noted that the length of history of pain was significantly longer in this naproxen group. Duration of the study was 14 days. Clinical parameters showed that the best degree of improvement was obtained with the diclofenac 50 mg twice-daily dosage regime. Diclofenac, in this study, showed better tolerability than naproxen.