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Comparison of 5‐fluorouracil with 5‐fluorouracil, cyclophosphamide, and methotrexate in metastatic colorectal carcinoma

Thirty‐eight patients with metastatic colorecal carcinoma were treated with 5‐fluorouracil (5‐FU), and 38 patients were treated with the combination of 5‐FU, cyclophosphamide, and methotrexate. In terms of percent response, response duration, and survival there was no apparent difference between the two regimens. Combination chemotherapy was found to be effective in 6 of 16 patients refractory to treatment with 5‐FU alone, but was associated with more morbidity.