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Lambert-Eaton myasthenic syndrome: Electrodiagnostic findings and response to treatment

Article abstract The authors reviewed the incidence of cancer, repetitive nerve stimulation findings, and response to treatment in 73 patients with Lambert-Eaton myasthenic syndrome. Thirty-one patients (42%) had lung cancer, 29 small cell. Doubling of the compound motor action potential amplitude in three tested distal muscles was seen in only 41% of patients. Treatment with 3,4-diaminopyridine produced moderate to marked self-reported functional improvement in 79% of the 53 treated patients.