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Optimal Sequencing of Dynamic Multileaf Collimators

Dynamic multileaf collimator (DMLC)-intensity modulated radiation therapy (IMRT) is used to delivery intensity-modulated beams using an MLC, with the leaves in motion. DMLC-IMRT requires the conversion of a radiation fluence map into a leaf sequence file that controls the movement of the MLC while the beam is on. It is imperative that the fluence map delivered using the leaf sequence file be as close as possible to the fluence map generated by the dose optimization algorithm, while satisfying hardware constraints of the delivery system. Optimization of the leafsequencing algorithm has been the subject of several recent investigations. In this work, we present a systematic study of the optimization of leaf sequencing algorithms for dynamic multileaf collimator beam delivery and provide rigorous mathematical proofs of optimized leaf sequence settings in terms of monitor unit (MU) efficiency under most common leaf movement constraints that include leaf interdigitation constraint. Our analytical analysis shows that leaf sequencing based on unidirectional movement of the MLC leaves is as MU efficient as bi-directional movement of the MLC leaves. Submitted to: Phys. Med. Biol. Optimal Sequencing of Dynamic Multileaf Collimators 2