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Small bowel ischaemia in Fabry's disease

Abstract A patient with previously diagnosed Fabry's disease and a long history of post‐prandial abdominal pain died following small bowel infarction. Post‐mortem demonstrated Fabry's type deposits in the small vessels and nerves supplying the bowel but in addition, a localized atheromatous stenosis of the superior mesenteric artery. In retrospect, his terminal illness and possibly his chronic symptoms were related to the latter finding. Angioplasty to the superior mesenteric artery may have been of benefit. Mesenteric angiography should be considered in patients with chronic post‐prandial pain because large vessel disease may coexist with other a priori pathologies and is imminently treatable.