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Eczema provoked by methyl dopa

Sixteen patients are described in whom seborrhoeic or nummular eczema erupted while they were taking methyl dopa. The eruption only responded to treatment when the methyl dopa was stopped. In eight patients who had recovered, test doses of methyl dopa caused rapid recurrence of eczema. The mechanism is obscure but appears to be provocation of endogenous eczema rather than a true drug eruption.