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P53 immunostaining in skin biopsies may assist the diagnosis of actinic keratosis

Actinic keratosis (AK) is a common intraepithelial neoplastic lesion occurring on sun-damaged skin which is accepted as a precursor of invasive carcinomas [1]. The differential diagnosis of AK includes many benign lesions such as solar lentigo, seborrheic keratosis, discoid lupus erythematosus, verrucous nevi, and warty dyskeratoma [1, 2]. We previously reported the demographic results of biopsied AK lesions and their histopathologic groups as a conference paper [3]. In the assessment of biopsied AK lesions immunohistochemistry has been suggested to reduce the subjectivity in histopathologic evaluations [2, 4, 5].