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A backside-illuminated low-noise multispectral imager for near-infrared fluorescence image-guided surgery (Conference Presentation)

Near-infrared fluorescence image-guided surgery offers substantial benefits for both surgeons and patients, but high-performance near-infrared fluorescent molecular markers are not available for clinical application. To enable adoption of a wider variety of fluorescent markers, we have developed a single-chip snapshot multispectral imaging system that combines a scientific CMOS image sensor with high quantum efficiency (94%), low read noise (1.6 e-), and high dynamic range (91 dB) and pixelated interference filters that enable color/near-infrared imaging without co-registration error The fully integrated imaging system is currently being evaluated for tumor detection with targeted probes and sentinel lymph node detection with indocyanine green.