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[Joint bleeding in haemophiliacs receiving substitution treatment as out-patients (author's transl)].

15 patients with severe haemophilia A recorded the rate and course of acute joint bleedings during one year. The episodes treated by replacement were compared with those not so treated. From the results it is evident, that treatment with factor VIII concentrates (n equal 8) alone does not completely prevent haemophilic arthropathy, but may reduce it in the individual cases to a level where it only occurs with higher bleeding rates. The bleeding rate depends mainly on the stage of the arthropathy. There is significant improvement of joint movement and significant regression of joint circumference after infusion treatment. Acute joint bleedings in haemophiliacs can be successfully treated by a combination of haemostatic and anti-inflammatory substances, as well as by physiotherapy and orthopaedic means.