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Mefloquine Effect on Disposition of Halofantrine in the Isolated Perfused Rat Liver

Halofantrine and mefloquine are antimalarial drugs used in the treatment of malaria, including that caused by chloroquine‐resistant Plasmodium falciparum. Reports of drug‐associated adverse reactions, including sudden death in one patient, have prompted concerns over the safety of halofantrine and the potential for drug‐drug interactions. We used the isolated perfused rat liver (IPRL) model to investigate a possible hepatic metabolic or pharmacokinetic drug‐drug interaction between halofantrine and mefloquine.