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Comparison of the Morphological Transforming Activities of Fjord-Region PAHs with Dibenzo[a, e]Pyrene and Benzo[a]Pyrene

Abstract The morphological transforming activities in mouse embryo C3H10T1/2CL8 (C3H10T1/2) cells were examined for six PAHs: benzo[c]chrysene (B[c]C); benzo[g]chrysene (B[g]C); benzo[c]phenanthrene (B[c]P); dibenzo[a, l]pyrene (DB[a, l]P); dibenzo[a,e]pyrene (DB[a,e]P) and benzo[a]pyrene (B[a]P). C3H10T1/2 cells treated with B[c]P or B[g]C at concentrations of 0–3 μg/ml did not produce any transformed Type II or III foci after 24 hr of exposure. Concurrent cytotoxicity was observed. Under the same conditions, B[a]P and B[c]C were active, with B[c]C approximately one-half the activity of B[a]P. However, after a 48-hr treatment, B[c]P and B[g]C gave significant activity measured as both foci/dish or the number of dishes exhibiting foci. After a 24-hr treatment, comparison of B[a]P with two dibenzopyrenes, DB[a, l]P and DB[a,e]P, gave activities in the order: DB[a, l]P > B[a]P > DB[a,e]P. After 48 hr of treatment, both B[a]P and DB[a,e]P had similar activities.