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[Neovir, an interferon inductor, modifies expression of steroid hormone receptors in hormone-dependent tissues and restores sensitivity to tamoxifen in patients with inoperable breast cancer].

A low-molecular inductor of interferon-neovir-was found to increase the expression of estrogen and progesterone receptors in the uterus of ovariectomized rats weighing 210-230 g. It also gave more edge to progesterone receptors and reduced the receptor-reducing effect of tamoxifen in relatively young rats weighing 120-140 g. Sensitivity of breast tumor tissue to tamoxifen was restored and a 60-170 day-long period (observation time) of stabilization of the process ensued in 8 out of 10 patients, following administration of a total dose of 2,000 mg neovir (during one month) to patients with extensive breast tumors resistant to tamoxifen.